Name,Organisations,Sector,Abstract,Title,Programme,Stop Date,Start Date,EC Contribution 'RTILS-GELS',University of Portsmouth,health,"Underpinned by pharmaceutical-industry estimates that approximately 40% of lipophilic therapeutic molecules are rejected because of their poor aqueous solubility and formulation-stability issues, one of the main challenges facing modern pharmaceutical science is the development of carrier vehicles for the extended delivery of such drug candidates. Additional impetus for such research activities is provided by the potential of such carriers to improve the therapeutic profiles of many of the widely used hydrophobic chemotherapeutants. Nowday, carrier vehicles for the delivery of hydrophobic drugs are associated with several disadvantages: conventional emulsions, micelles and liposomes are thermodynamically unstable; lipophilic carriers cluster in blood flow and are rapidly opsonized and massively cleared by liver and spleen; loading capacity of hydrophobic drugs into hydrophilic carriers is limited. Rationalised in the terms of thermodynamic stability, capability to move through blood capillaries, imrpoved drug loading capacity, surface-charged hydrophilicity, and capacity to effect controlled drug release, one of the approaches towards addressing these issues involves the use of superabsorbent polyelectrolytes-based nanogels with affinity for both water and organic liquids. Towards the development of biomaterials for the delivery of hydrophobic drugs, in this project, biocompatible, polymerisable Room Temperature Ionic Liquids (RTILs) based on 1-vinylimidazole and amino acids, as well as nanoparticulate co-polymeric gels of the same RTILs and 2-hydroxyethyl methacrylate (HEMA)/1-vinyl-2-pyrrolidone (NVP) with superabsorbency for both water and several organic liquids will be synthesized and characterised. The suitability of the nanogels to be a novel delivery platform for hydrophobic/aqueously unstable drugs will be assessed in vitro in the terms of biocompatibility, drug uploading and release profiles.",Novel Delivery Platform for Hydrophobic Drugs,FP7,14 January 2016,15 January 2014,309235.0 1DH2OP,University of Cambridge,health,"Sunlight is a vastly abundant energy form and provides an attractive possible energy-input to produce hydrogen through the splitting of water into its elements via the process of artificial photosynthesis. Within this theme, the proposal defines a new approach of coupling semiconductor nanomaterials with catalytically active biological enzymes to reduce protons to hydrogen in an aqueous electrolyte under visible light irradiation. Building upon current state-of-the-art systems involving enzymes attached to dye-sensitized titanium dioxide nanoparticulates, herein we propose the use of one-dimensional titanium dioxide nanostructures. Benefitting from the intrinsic property of efficient directional electron transport, these structures will reduce charge recombination and hence could lead to improved performance. The visible light driven response via anion doping will eliminate the need for a ruthenium dye as photosensitizer, offering promise of a low cost and greatly simplified hybrid design. Moreover, upon suitable valence band position engineering, the addition of an organic pollutant could act as electron donor to enhance hydrogen production, while simultaneously being photodegraded. This project brings innovation and advancement to the concept and design of more efficient and cost effective biomimetic artificial photosynthesis increasing the competitiveness of the European Research Area in renewable energy research. In line with action 2 of the FP7 Work Program-PEOPLE, this multidisciplinary project (4 major thematic areas: energy, nanoscience, biotechnology, and environmental) intends to train and develop Dr. Lee personally and professionally, reinforcing his career development.",Coupling of One-Dimensional TiO2 with Hydrogenase: Simultaneous Visible-Light Driven H2 Production and Treatment of an Organic Pollutant,FP7,31 August 2015,01 March 2014,231926.0 1MOLECULENEARPLASMON,Universiteit Leiden * Leiden University,health,"Our project is to combine single-molecule spectroscopy with plasmonic nanomaterials. We will use the fluorescence excitation lines of single molecules in a cryogenic experiment to probe the local field enhancement of single plasmonic antennas, as well as of periodic array of antennas. At low tem-peratures, spectral selection will enable us to address a large number of molecules (typically 100,000) independently in each focal spot, by tuning the excitation laser. Thereby, we will determine the position of the excited molecule by superresolution techniques and correlate it with its emission properties. The linewidth and saturation fluorescence intensity of each molecule will be used to determine the local field enhancement. By selecting many individual molecules, we will map the local field and the associated enhancement of the molecular emission. Compared to previous experiments, this method is non-invasive, non-destructive, and still provides high spatial resolution. The local-field map will be used for further optimization of the nanoantennas in collaboration with a group in charge of the nanofabrication. The optimized antennas will allow us to enhance light-matter interaction and eventually, to manipulate single photons with single molecules.",Single-molecule spectroscopy in the near field of plasmonic metal nanoparticles,FP7,31 March 2014,01 April 2012,183805.0 2020 INTERFACE,University of Leeds,transport,"Durability and friction control in internal combustion engines is currently delivered from a complex package of lubricant additives in a fully formulated engine oil. These oil additives, through tribochemical interaction with the surface, produce nanostructured composite, self-healing and smart tribofilms at the surface. 2020 Interface involves the design of the complete system; functionalised Diamond-like Carbon (DLC) coating and future generation lubricant to enable the Europe’s stretching targets in fuel economy and durability to be met. There has been much emphasis in research on designing new coatings technology such that the degree of complexity of surface systems has increased dramatically over the last decade. In boundary lubricated contacts, it is the interfacial nanostructured film, which results from tribochemical interactions between the surface and the lubricant additives, which dictates the system performance. No attempts have been made to incorporate “design” strategies into optimizing this interface and 2020 Interface tackles this through an interdisciplinary integrated experimental and theoretical approach. The benefits of this approach are accrued from substantial improved fuel economy (protection of natural resources), reduced emissions (protection of the environment) and improved durability (lower waste and maintenance). As the number of vehicles in the globe increases year on year without showing signs of reaching a plateau and the internal combustion engine remains the major platform for powertrain for the foreseeable future, the impact of this project will be large and long lasting. 2020 Interface brings together a world class consortium of 4 Universities, 1 research institute and 4 leading multinational companies from 8 EU countries together in complete supply chain to deliver fast track radical innovation in nanoscience through to a full set of novel lubrication technology platforms, for commercial applications in diesel and",Tailoring of Tribological Interfaces for Clean and Energy-Efficient Diesel and Gasoline Power Trains,FP7,05 July 2015,12 January 2009,2591690.0 2D-HETEROSTRUCTURES,Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR),health,"One-atom thin two-dimensional nanomaterials possess unique properties different from their bulk counterparts. Initiated by the discovery of graphene, many stable one atom-thick layers such as boron nitride, molybdenum disulphide, tungsten disulphide etc., have been isolated and characterized. However, the individual properties of such 2D-atomic crystals (except graphene) were modest. The combination of isolated single atomic layers into designer structures, named as 2D-heterostrcutures, is predicted to give synergetic properties. In order to harness the interesting properties the combination of various 2D-atomic crystals have to offer, a method to assemble them in a simple and scalable way is required. Currently, the only method known is manual placing of the 2D-atomic crystal layers sequentially which limits the scope of the study of such structures. The objective of the proposal is to assemble layered (each layer is one atom thick) stacks of graphene superlattices and heterostructures with other 2D-atomic crystals such as BN, MoS2, WS2 etc., by deoxyribonucleic acid (DNA)-mediated assembly. DNA mediated assembly is highly programmable by chemically specific interaction between nucleotides, length of the DNA, strength of the interactions in addition to the symmetry control of the assembled structures. Top-down lithography will be combined with bottom-up DNA assembly to fabricate seed layers of DNA for the guided assembly which lead to patterned heterostructures. This approach is targeted toward combinatorial screening of exotic properties of varied architectures of heterostructures with control over the composition of 2D-atomic crystals and spacing between the layers (controlled by DNA). The anticipated structures would be vertical atomic scale Legos of 2D-atomic crystal layers with DNA spacers.",Graphene Heterostructures by Self-Assembly:Top-down meets Bottom-up,FP7,,,15000.0 2D-HETEROSTRUCTURES,University of Manchester,health,"One-atom thin two-dimensional nanomaterials possess unique properties different from their bulk counterparts. Initiated by the discovery of graphene, many stable one atom-thick layers such as boron nitride, molybdenum disulphide, tungsten disulphide etc., have been isolated and characterized. However, the individual properties of such 2D-atomic crystals (except graphene) were modest. The combination of isolated single atomic layers into designer structures, named as 2D-heterostrcutures, is predicted to give synergetic properties. In order to harness the interesting properties the combination of various 2D-atomic crystals have to offer, a method to assemble them in a simple and scalable way is required. Currently, the only method known is manual placing of the 2D-atomic crystal layers sequentially which limits the scope of the study of such structures. The objective of the proposal is to assemble layered (each layer is one atom thick) stacks of graphene superlattices and heterostructures with other 2D-atomic crystals such as BN, MoS2, WS2 etc., by deoxyribonucleic acid (DNA)-mediated assembly. DNA mediated assembly is highly programmable by chemically specific interaction between nucleotides, length of the DNA, strength of the interactions in addition to the symmetry control of the assembled structures. Top-down lithography will be combined with bottom-up DNA assembly to fabricate seed layers of DNA for the guided assembly which lead to patterned heterostructures. This approach is targeted toward combinatorial screening of exotic properties of varied architectures of heterostructures with control over the composition of 2D-atomic crystals and spacing between the layers (controlled by DNA). The anticipated structures would be vertical atomic scale Legos of 2D-atomic crystal layers with DNA spacers.",Graphene Heterostructures by Self-Assembly:Top-down meets Bottom-up,FP7,30 April 2016,01 May 2014,221606.0 2D-NANOLATTICES,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),information and communications technology,"Graphite-like 2D nanolattices of dielectrics and semiconductors with enhanced anisotropic electronic properties are good candidates to pave the way to the ultimate scaling and performances of future nanoelectronic devices. Graphene, the most studied representative of the 2D graphitic materials, has overshadowed research on other potential 2D nanolattices with totally unexplored physical properties. One such 2D lattice, silicene (germanene), the Si (Ge) sp2-hybridized equivalent of graphene, if it exists, may offer better compatibility with silicon processing and may provide solutions for some of the problems of graphene associated with the lack of an energy gap. In this proposal we will focus on finding ways to induce and stabilize sp2 hybridization in Si and Ge and prove for the first time that silicene has a physical existence. This should be combined with similarly sp2-hybridized dielectrics which could offer a template for silicene and germanene growth and, at the same time, serve as gate insulators which are necessary for charge and current control in the 2D semiconductors. The ideal situation would be to obtain a sequence of sp2-hybridized dielectric/silicene alternating monolayers which are weakly bonded between each other in the vertical direction via van der Waals forces. A strong anisotropy could also be induced by regular sp3-hybridized ultrathin Si and Ge in which the periodicity along the vertical growth direction is artificially broken by the insertion of monolayer-thick non- semiconducting layers. In such a case, the bandstructure and the density of states could be strongly modified reducing in-plane effective mass while inhibiting the transport perpendicular to the layers. This could reduce gate leakage and carrier scattering, thus maintaining high mobility at low equivalent oxide thickness.",Strongly anisotropic Graphite-like semiconductor/dielectric 2D nanolattices,FP7,08 July 2016,06 January 2011,1628539.0 2D-USD,Trinity College Dublin,energy,"This proposal will determine the technical and economic viability of scaling up ultra-thin film deposition processes for exfoliated single atomic layers. The PI has developed methods to produce exfoliated nanosheets from a range of layered materials such as graphene, transition metal chalcogenides and transition metal oxides. These 2D materials have immediate and far-reaching potential in several high-impact technological applications such as microelectronics, composites and energy harvesting and storage. 2DNanoCaps (ERC ref: 278516) has already demonstrated that lab-scale ultra-thin graphene-based supercapacitor electrodes for energy storage result in unusually high power performance and extremely long device life-time (100% capacitance retention for 5000 charge-discharge cycles at the high power scan rate of 10,000 mV/s). This performance is remarkable- an order of magnitude better than similar systems produced with more conventional methods, which cause materials restacking and aggregation. 2D nanosheets also offer the chance of exploring the unique possibility of manufacturing conductive, robust, thin, easily assembled electrode and solid electrolytes to realize highly flexible and all-solid-state supercapacitors. This opportunity is particularly relevant from the industrial point of view especially in relation to the flammability issues of the electrolytes used for commercial energy storage devices at present. In order to develop and exploit any of the applications listed above, it will be imperative to develop deposition methods and techniques capable of obtaining industrial-scale 'sheet-like' coverage, where flake re-aggregation is avoided. We believe our combination of unique material properties and cost effective, robust and production-scalable process of ultra-thin deposition will enable us to compete for significant global market opportunities in the energy-storage space",Ultrasonic Spray Deposition: Enabling new 2D based technologies,FP7,31 December 2014,01 January 2014,148021.0 2DMATER,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),energy,"Two-dimensional (2D) nanosheets, which possess a high degree of anisotropy with nanoscale thickness and infinite length in other dimensions, hold enormous promise as a novel class of ultrathin 2D nanomaterials with various unique functionalities and properties, and exhibit great potential in energy storage and conversion systems that are substantially different from their respective 3D bulk forms. Here I propose a strategy for the synthesis and processing of various 2D nanosheets across a broad range of inorganic, organic and polymeric materials with molecular-level or thin thickness through both the top-down exfoliation of layered materials and the bottom-up assembly of available molecular building blocks. Further, I aim to develop the synthesis of various 2D-nanosheet based composite materials with thickness of less than 100 nm and the assembly of 2D nanosheets into novel hierarchal superstrucutures (like aerogels, spheres, porous particles, nanotubes, multi-layer films). The structural features of these 2D nanomaterials will be controllably tailored by both the used layered precursors and processing methodologies. The consequence is that I will apply and combine defined functional components as well as assembly protocols to create novel 2D nanomaterials for specific purposes in energy storage and conversion systems. Their unique characters will include the good electrical conductivity, excellent mechanical flexibility, high surface area, high chemical stability, fast electron transport and ion diffusion etc. Applications will be mainly demonstrated for the construction of lithium ion batteries (anode and cathode), supercapacitors (symmetric and asymmetric) and fuel cells. As the key achievements, I expect to establish the delineation of reliable structure-property relationships and improved device performance of 2D nanomaterials.",Controlled Synthesis of Two-Dimensional Nanomaterials for Energy Storage and Conversion,FP7,31 August 2017,01 September 2012,1500000.0 2DNANOCAPS,Trinity College Dublin,energy,"Climate change and the decreasing availability of fossil fuels require society to move towards sustainable and renewable resources. 2DNanoCaps will focus on electrochemical energy storage, specifically supercapacitors. In terms of performance supercapacitors fill up the gap between batteries and the classical capacitors. Whereas batteries possess a high energy density but low power density, supercapacitors possess high power density but low energy density. Efforts are currently dedicated to move supercapacitors towards high energy density and high power density performance. Improvements have been achieved in the last few years due to the use of new electrode nanomaterials and the design of new hybrid faradic/capacitive systems. We recognize, however, that we are reaching a newer limit beyond which we will only see small incremental improvements. The main reason for this being the intrinsic difficulty in handling and processing materials at the nano-scale and the lack of communication across different scientific disciplines. I plan to use a multidisciplinary approach, where novel nanomaterials, existing knowledge on nano-scale processing and established expertise in device fabrication and testing will be brought together to focus on creating more efficient supercapacitor technologies. 2DNanoCaps will exploit liquid phase exfoliated two-dimensional nanomaterials such as transition metal oxides, layered metal chalcogenides and graphene as electrode materials. Electrodes will be ultra-thin (capacitance and thickness of the electrodes are inversely proportional), conductive, with high dielectric constants. Intercalation of ions between the assembled 2D flakes will be also achievable, providing pseudo-capacitance. The research here proposed will be initially based on fundamental laboratory studies, recognising that this holds the key to achieving step-change in supercapacitors, but also includes scaling-up and hybridisation as final objectives.",Next Generation of 2D-Nanomaterials: Enabling Supercapacitor Development,FP7,30 September 2016,01 October 2011,1501296.0 2DTHERMS,University of Santiago de Compostela * Universidade de Santiago de Compostela,energy,Design of new thermoelectric devices based on layered and field modulated nanostructures of strongly correlated electron systems,Design of new thermoelectric devices based on layered and field modulated nanostructures of strongly correlated electron systems,FP7,31 October 2015,01 November 2010,1427190.0 3-TOP,Julius Maximilians University of Würzburg * Julius-Maximilians-Universität,information and communications technology,"Topological insulators constitute a novel class of materials where the topological details of the bulk band structure induce a robust surface state on the edges of the material. While transport data for 2-dimensional topological insulators have recently become available, experiments on their 3-dimensional counterparts are mainly limited to photoelectron spectroscopy. At the same time, a plethora of interesting novel physical phenomena have been predicted to occur in such systems.",Exploring the physics of 3-dimensional topological insulators,FP7,03 July 2018,04 January 2011,0.0 3D NANOCHEMISCOPE,ION-TOF Gesellschaft für Massenspektrometern mbH,manufacturing,"The objective of this project is to develop an innovative and novel combination of a new TOF-SIMS with substantially improved lateral resolution and sensitivity, combined with a new metrological high resolution SFM. The two techniques provide complementary information on nanoscale surface chemistry and surface morphology. In combination with a layer by layer removal of material using low energy sputtering, quantitatively measured by SFM, this combined ultra-high vacuum (UHV) instrument will be unique for the 3-dimensional chemical characterisation of nanostructured inorganic as well as organic materials with down to at least 10 nm lateral resolution and down to 1 nm depth resolution. Joint by a novel software for the calculation and display of 3-dimensional distributions of all chemical species, this leads to a totally new “3D NanoChemiscopeâ€.",Combined SIMS-SFM Instrument for the 3-Dimensional Chemical Analysis of Nanostructures,FP7,01 February 2014,09 March 2009,4033699.0 3D-FM,Universiteit Leiden * Leiden University,health,"I propose to pursue two emerging Force Microscopy techniques that allow measuring structural properties below the surface of the specimen. Whereas Force Microscopy (most commonly known under the name AFM) is usually limited to measuring the surface topography and surface properties of a specimen, I will demonstrate that Force Microscopy can achieve true 3D images of the structure of the cell nucleus. In Ultrasound Force Microscopy, an ultrasound wave is launched from below towards the surface of the specimen. After the sound waves interact with structures beneath the surface of the specimen, the local variations in the amplitude and phase shift of the ultrasonic surface motion is collected by the Force Microscopy tip. Previously, measured 2D maps of the surface response have shown that the surface response is sensitive to structures below the surface. In this project I will employ miniature AFM cantilevers and nanotube tips that I have already developed in my lab. This will allow me to quickly acquire many such 2D maps at a much wider range of ultrasound frequencies and from these 2D maps calculate the full 3D structure below the surface. I expect this technique to have a resolving power better than 10 nm in three dimensions as far as 2 microns below the surface. In parallel I will introduce a major improvement to a technique based on Nuclear Magnetic Resonance (NMR). Magnetic Resonance Force Microscopy measures the interaction of a rotating nuclear spin in the field gradient of a magnetic Force Microscopy tip. However, these forces are so small that they pose an enormous challenge. Miniature cantilevers and nanotube tips, in combination with additional innovations in the detection of the cantilever motion, can overcome this problem. I expect to be able to measure the combined signal of 100 proton spins or fewer, which will allow me to measure proton densities with a resolution of 5 nm, but possibly even with atomic resolution.",Taking Force Microscopy into the Third Dimension,FP7,31 July 2013,01 August 2008,1794960.0 3D-NANOBIODEVICE,Malmo University * Malmö Högskola,health,"The main scientific objective of the project is to enhance the understanding of the fundamental principles for controlling electron transfer reactions between nanoparticles (NPs), carbon nanotubes (CNTs), their assemblies confined into three-dimensional (3D) microscale networks, conductive nano/-microporous silicone (NMPSi) chips and different bioelements, such as glucose oxidising and oxygen reducing enzymes. The technological objective of the project is to construct potentially implantable microscale self-contained wireless biodevices working in different biomatrices, e.g. blood, plasma, saliva. Novel biodevices will be constructed by combination of glucose and oxygen sensitive biosensors powered by biofuel cells, all made from 3D nanobiostructured materials and operated by wireless microtransmitter/transducer system. To produce 3D microscale devices with superior characteristics mathematical modelling of their performance will be compared against experimentally determined parameters. Nanowiring of appropriate redox enzymes with NPs, CNTs, proper surface modifications, and use of Os and Ru redox complexes, are chosen as a major direction to solve main obstacles in the area of bioelectronics, i.e. poor electronic communication between the biocomponents and the electronic elements along with insufficient operational stability. The 3D structure of nanobiodevices will provide very high efficiency and stability along with their miniaturisation for successful application in biomedicine and health care. The developed, wireless self-contained and potentially implantable, 3D nanobiostructure-based devices will be used to improve quality of life and increase safety in case of widely occurring chronic diseases. Moreover, in the long-term, 3D nanobiostructure-based elements will be essential for constructing devices to be used for neuron/nerve stimulations and compensation of human disabilities.",Three-dimensional nanobiostructure-based self-contained devices for biomedical application,FP7,30 June 2012,01 July 2009,3548000.0 3D-OA-HISTO,University of Oulu * Oulun Yliopisto,health,"Background: Osteoarthritis (OA) is a common musculoskeletal disease occurring worldwide. Despite extensive research, etiology of OA is still poorly understood. Histopathological grading (HPG) of 2D tissue sections is the gold standard reference method for determination of OA stage. However, traditional 2D-HPG is destructive and based only on subjective visual evaluation. These limitations induce bias to clinical in vitro OA diagnostics and basic research that both rely strongly on HPG. Objectives: 1) To establish and validate the very first 3D-HPG of OA based on cutting-edge nano/micro-CT (Computed Tomography) technologies in vitro; 2) To use the established method to clarify the beginning phases of OA; and 3) To validate 3D-HPG of OA for in vivo use. Methods: Several hundreds of human osteochondral samples from patients undergoing total knee arthroplasty will be collected. The samples will be imaged in vitro with nano/micro-CT and clinical high-end extremity CT devices using specific contrast-agents to quantify tissue constituents and structure in 3D in large volume. From this information, a novel 3D-HPG is developed with statistical classification algorithms. Finally, the developed novel 3D-HPG of OA will be applied clinically in vivo. Significance: This is the very first study to establish 3D-HPG of OA pathology in vitro and in vivo. Furthermore, the developed technique hugely improves the understanding of the beginning phases of OA. Ultimately, the study will contribute for improving OA patients' quality of life by slowing the disease progression, and for providing powerful tools to develop new OA therapies.",Development of 3D Histopathological Grading of Osteoarthritis,FP7,31 January 2019,01 February 2014,1500000.0 3DCELLART,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Bacterial infection into host cells is an important and highly active field of research. Understanding the interactions and the distribution of the host-cell scaffolding protein network during bacterial entry poses a major challenge. The molecular architecture of actin comet tails, filamentous structures assembled by internalized bacteria to move inside the host-cell cytoplasm and from cell-to-cell, remains unknown. Cryo-electron tomography (cryo-ET) is the most advanced method for visualizing the architecture of hydrated cells at a resolution better than 5 nm. Cryo-ET will be used to visualize the three dimensional (3D) cytoskeleton reorganization directly in eukaryotic cells infected by Listeria. Measurements will be performed at cryo-temperatures, on vitrified cell samples preserved in a close-to-life state. Specimen thickness limitations will be overcome by the use of the focused ion beam (FIB) micro-machining method, to obtain 500 nm thick samples as required for the collection of good data. Cryo-ET will be combined with correlative cryo-fluorescence microscopy, to localize the scaffolding components recruited during Listeria uptake and motility: host-cell actin, septin and clathrin. We expect to achieve nanometer resolution maps of the cell area of interest. The distribution and the ultrastructure of the cytoskeletal scaffold at Listeria entry and of Listeria actin comet tails will be provided. The work will provide unprecedented insight into cytoskeleton architecture during bacterial pathogenesis. The applicant obtained her PhD at a structural biology institute in France. Joining the Baumeister laboratory in Germany, and collaborating with the Cossart group, will allow her to address new challenging questions on the structural organisation of the cell, at unprecedented resolution. The acquired combination of skills at a world-class level will contribute significantly to her professional maturity, and to increase the competitiveness of European science.",Cytoskeleton architecture in host cells during Listeria infection using cryo-electron tomography,FP7,31 December 2013,01 January 2012,162242.0 3DIMAGE,University of Cambridge,energy,"Understanding structure-property relationships across lengthscales is key to the design of functional and structural materials and devices. Moreover, the complexity of modern devices extends to three dimensions and as such 3D characterization is required across those lengthscales to provide a complete understanding and enable improvement in the material's physical and chemical behaviour. 3D imaging and analysis from the atomic scale through to granular microstructure is proposed through the development of electron tomography using (S)TEM, and 'dual beam' SEM-FIB, techniques offering complementary approaches to 3D imaging across lengthscales stretching over 5 orders of magnitude. We propose to extend tomography to include novel methods to determine atom positions in 3D with approaches incorporating new reconstruction algorithms, image processing and complementary nano-diffraction techniques. At the nanoscale, true 3D nano-metrology of morphology and composition is a key objective of the project, minimizing reconstruction and visualization artefacts. Mapping strain and optical properties in 3D are ambitious and exciting challenges that will yield new information at the nanoscale. Using the SEM-FIB, 3D 'mesoscale' structures will be revealed: morphology, crystallography and composition can be mapped simultaneously, with ~5nm resolution and over volumes too large to tackle by (S)TEM and too small for most x-ray techniques. In parallel, we will apply 3D imaging to a wide variety of key materials including heterogeneous catalysts, aerospace alloys, biomaterials, photovoltaic materials, and novel semiconductors. We will collaborate with many departments in Cambridge and institutes worldwide. The personnel on the proposal will cover all aspects of the tomography proposed using high-end TEMs, including an aberration-corrected Titan, and a Helios dual beam. Importantly, a postdoc is dedicated to developing new algorithms for reconstruction, image and spectral processing.",3D Imaging Across Lengthscales: From Atoms to Grains,FP7,31 December 2016,01 January 2012,2337330.0 3DINVITRONPC,Consejo Superior De Investigaciones Científicas (CSIC),health,"The applications for nanoparticles (NPs) in medicine have rapidly increased in recent years; some examples are drug delivery, medical imaging, in vitro biosensors and cancer treatment. Typically, the biological assessment of NPs is carried out first in vitro (in a 2D petri dish) and then in small animals in vivo (3D). This whole process is costly and time consuming; similarly to that is required for the drug development, 11-15 years and $500 to $800 million to reach the market. An intermediate step between (2D) in vitro and (3D) in vivo assays could provide relevant information, decreasing the total cost of the biological assessment. 3D in vitro assays mimic biologically relevant tissues in an economical and rapid manner; although, current 3D in vitro methods entail complex engineering steps. 3DinvitroNPC focuses on a simple and innovative strategy to create 3D in vitro cell cultures using sheets of porous materials and embedding living cells and NPs within those materials. 3D cell cultures require a material non-toxic for cells and highly porous to allow cells to grow within its microstructure. This project explores aerogels of biomaterials to create 3D in vitro novel scaffolds that are biodegradable and transparent. Combinations of cells and NPs in the 3D in vitro constructs permits the assessment of viability and functionality of NPs in relevant biological environments which is critical for using NPs in medical applications. Gold NPs and FexOy-NPs will be assessed, the first as model NPs and the latter as magnetic label of cells. FexOy-NPs internalized by cells, magnetically label the cells. Localization of magnetic cells using a magnet placed outside the body is a recently developed medical method non-invasive for tissue recovery after cerebral ischemia. For this purpose, the platform of 3DinvitroNPC will evaluate magnetic cells within the on-purpose developed 3D cell scaffolds.",Interactions in Three-dimensional (3D) in vitro environments of Nanoparticles and Cells,FP7,31 January 2016,01 February 2012,100000.0 3DMAGNANOW,University of Cambridge,manufacturing,"The objective of the proposal is the fabrication and study of three dimensional (3D) magnetic nanowires for ultra-high density information storage. Current memory architectures are 2D, composed of one layer of active components. The extension of data storage devices into the third dimension could result in information densities of hundreds of Gb/in2, causing a technological revolution. The project aims at implementing a 3D version of the existing 2D host institution’s idea of domain wall based shift registers to store data. In this scheme, the data bits are stored using the two possible directions of the magnetisation in thin and narrow nanowires made of soft ferromagnetic materials. The fabrication of the 3D devices will be done by using a novel promising nanolithography technique: focused electron beam induced deposition (FEBID), with unique capabilities for the creation of 3D nanostructures. We have recently demonstrated the required possibility to control domain walls in cobalt nanowires created by this technique. The patterning of magnetic nanostructures by means of conventional lithography, such as electron beam lithography and ion milling, will be explored in parallel. The control of the domain walls will be probed by magneto-optical magnetometry and magneto-electrical measurements. The two directions to be investigated for the creation of 3D magnetic devices will be the stacking of 2D magnetic nanowires, and the direct fabrication of 3D nanowires. The host group possesses patents protecting the ideas presented in this proposal. The success of the project would place the European Union in a privileged position to lead the next steps in the development of Information Technology.",Fabrication of three dimensional magnetic nanowires for information storage,FP7,09 June 2014,10 January 2010,172740.8 3DNANOMECH,Consejo Superior De Investigaciones Científicas (CSIC),health,"Optical, electron and probe microscopes are enabling tools for discoveries and knowledge generation in nanoscale sicence and technology. High resolution –nanoscale or molecular-, noninvasive and label-free imaging of three-dimensional soft matter-liquid interfaces has not been achieved by any microscopy method. Force microscopy (AFM) is considered the second most relevant advance in materials science since 1960. Despite its impressive range of applications, the technique has some key limitations. Force microscopy has not three dimensional depth. What lies above or in the subsurface is not readily characterized. 3DNanoMech proposes to design, build and operate a high speed force-based method for the three-dimensional characterization soft matter-liquid interfaces (3D AFM). The microscope will combine a detection method based on force perturbations, adaptive algorithms, high speed piezo actuators and quantitative-oriented multifrequency approaches. The development of the microscope cannot be separated from its applications: imaging the error-free DNA repair and to understand the relationship existing between the nanomechanical properties and the malignancy of cancer cells. Those problems encompass the different spatial –molecular-nano-mesoscopic- and time –milli to seconds- scales of the instrument. In short, 3DNanoMech aims to image, map and measure with picoNewton, millisecond and angstrom resolution soft matter surfaces and interfaces in liquid. The long-term vision of 3DNanoMech is to replace models or computer animations of bimolecular-liquid interfaces by real time, molecular resolution maps of properties and processes.",Three-dimensional molecular resolution mapping of soft matter-liquid interfaces,FP7,31 January 2019,01 February 2014,2499928.0 3DNANOPRINT,Profactor GmbH,manufacturing,"The main problem in nanotechnology is the lack of methods for mass production. This is especially true for SMEs, which do not have the ability to invest in expensive equipment for large-scale production of nanostructures. Nanoimprint lithography on the other hand provides a tool that is comparably cheap and suited for mass production. 3D NANOPRINT aims at the development of a complete process technology with the necessary tools to produce 3-dimensional nanostructures with ultra high precision. In comparison to deep or extreme ultra violet lithography (abbreviated as DUV and EUV lithography respectively) this research paves the way for the widespread use of a nanoscale production technology also by smaller companies, since the investment costs of nanoimprint production lines are less than 1% of the DUV or EUV investments. The project consist of two levels, a directly process oriented part dealing with nanoimprint lithography itself, nanoimprint resists, reactive ion etching and alignment problems and an application oriented part. In this part requirements for nanoimprint lithography as production tool are defined, assuring that the final result of the project is a cost effective, high throughput, ultra-precise tool for the production of 3 dimensional nanostructures. As a reference application 3-dimensional photonic crystals have been chosen, since the optical properties of such devices are extremely sensitive to the quality of the production process (therefore are excellent indicators) and assure a high economic impact since the photonics market is growing quickly. Other applications considered are micro- and nano-optical devices.",Nanoimprint Lithography for Novel 2- and 3- dimensional Nanostructures,FP6,30 April 2007,01 November 2004,967980.2 3G-SCAFF,Uppsala University * Uppsala Universitet,health,"The project proposed is therefore a radically new approach to fabricate safe bioactive materials for tissue engineering and regenerative medicine. We propose to use cells as micro-factories to produce and assemble the molecular components at the nanometer level which is not possible by conventional mechanical engineering. This cellular engineering will be used to produce the supportive structure with desired shape, compliance and mechanical strength at meso- and macroscale levels. We achieve this by engineering cells to express the desired components creating bioartificial scaffolds which mimick the natural extracellular matrix and will fulfil the requirements of mechanical support, compartmentalization, storage and sequestration of molecules. This also will have correct porosity allowing for diffusion of soluble molecules and access to cells, exposing ligands for adhesion and proliferation and being degradable by enzymatic mechanisms to allow body directed remodelling.",Third Generation Scaffolds for Tissue Engineering and Regenerative Medicine,FP6,31 August 2008,01 March 2005,1732498.0 3MICRON,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"In vivo multimodality imaging is a fast growing field in medical research and, although the achievements at clinical level of this diagnostic method are recent, it is already one of the most promising approaches in the diagnosis of diseases in many research addressed medical centres. At present in this area, the USA plays the protagonist role as a result of the amount of resources engaged in the arena in the last decade. Both government and private companies agree, when considering the potential of this approach, that it is one of the foremost medical advancements as it will lead to early diagnosis of diseases with high impact on the societies of western countries. Multimodality imaging is currently viewed as a simple and powerful integration of two or more imaging methods (e.g. PET-CT). 3MICRON is an ambitious project which gathers some of the most advanced European medical and technical institutions together to address the design of new strategies in diagnostics, and to push the potential of medical imaging beyond the state-of-the-art. The multimodality approaches are supported by a class of next-generation micro/nanodevices called microballoons. These subsystems are able to implement the function of an ultrasound contrast agent with other imaging methods (SPECT, MRI). In the future, they may act as a minimally invasive drug delivery method and hyperthermia device. In 3MICRON, this multi-functional device will be tested in vitro and in vivo in order to assess bioclearance and cytoxicity effects toward high impact diseases, e.g. cardiovascular and inflammation pathologies. Finally, selected types of microballoons will undergo pre-clinical screening for a consolidated assessment of the 'bench-to-bed' pathway for these new microdevices.",Three modality contrast imaging using multi-functionalized microballoons,FP7,30 April 2013,01 May 2010,5999412.0 3PS,Higher Institute of Engineering of Porto * Instituto Superior de Engenharia do Porto (ISEP),health,"This project presents a new concept for the detection, diagnosis and monitoring of cancer biomarker patterns in point-of-care. The device under development will make use of the selectivity of the plastic antibodies as sensing materials and the interference they will play on the normal operation of a photovoltaic cell. Plastic antibodies will be designed by surface imprinting procedures. Self-assembled monolayer and molecular imprinting techniques will be merged in this process because they allow the self-assembly of nanostructured materials on a 'bottom-up' nanofabrication approach. A dye-sensitized solar cell will be used as photovoltaic cell. It includes a liquid interface in the cell circuit, which allows the introduction of the sample (also in liquid phase) without disturbing the normal cell operation. Furthermore, it works well with rather low cost materials and requires mild and easy processing conditions. The cell will be equipped with plasmonic structures to enhance light absorption and cell efficiency. The device under development will be easily operated by any clinician or patient. It will require ambient light and a regular multimeter. Eye detection will be also tried out.","3Ps Plastic-Antibodies, Plasmonics and Photovoltaic-Cells: on-site screening of cancer biomarkers made possible",FP7,31 January 2018,01 February 2013,998584.0 3SPIN,Imperial College London,manufacturing,"Spintronics, in which both the spin and the charge of the electron are used, is one of the most exciting new disciplines to emerge from nanoscience. The 3SPIN project seeks to open a new research front within spintronics: namely 3-dimensional spintronics, in which magnetic nanostructures are formed into a 3-dimensional interacting network of unrivalled density and hence technological benefit. 3SPIN will explore early-stage science that could underpin 3-dimensional metallic spintronics. The thesis of the project is: that by careful control of the constituent nanostructure properties, a 3-dimensional medium can be created in which a large number of topological solitons can exist. Although hardly studied at all to date, these solitons should be stable at room temperature, extremely compact and easy to manipulate and propagate. This makes them potentially ideal candidates to form the basis of a new spintronics in which the soliton is the basic transport vector instead of electrical current. ¬3.5M of funding is requested to form a new team of 5 researchers who, over a period of 60 months, will perform computer simulations and experimental studies of solitons in 3-dimensional networks of magnetic nanostructures and develop a laboratory demonstrator 3-dimensional memory device using solitons to represent and store data. A high performance electron beam lithography system (cost 1M¬) will be purchased to allow state-of-the-art magnetic nanostructures to be fabricated with perfect control over their magnetic properties, thus allowing the ideal conditions for solitons to be created and controllably manipulated. Outputs from the project will be a complete understanding of the properties of these new objects and a road map charting the next steps for research in the field.",Three Dimensional Spintronics,FP7,02 May 2018,03 January 2010,2799995.6 4FNANOMAG,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),information and communications technology,"The design of molecular nanoscale magnets is a hot topic research area due to their technological interest in high density data storage or quantum computing. In this field, lanthanide-containing systems are appealing due to the large magnetic moment and large anisotropy associated with most of the lanthanides, key factors determining the temperature below which single-molecule(SMMs) and single-chain magnets(SCMs) retain the magnetization due to its slow relaxation. Whereas 3d-based molecular nanomagnets have been largely studied and their relaxation mechanisms are well understood, little is known for their novel 4f-based counterparts. For this reason, the aim of this project is to fulfill this lack of knowledge in order to support a future rational design of 4f-based nanomagnets for technological applications. For that, several theoretical methods will be employed: Quantum Chemistry methods for computing the Stark sublevels of the lanthanide ions, theoretical models for describing the dynamics of the magnetization in 4f-based nanomagnets and statistical physic methods for modeling the behaviour of the 4f-based SCMs. Moreover, X-ray, spectroscopic and magnetic measurements will be needed in order to provide suitable experimental data for developing and testing the theoretical studies. Due to the profile of the project, LAMM laboratory, one of the world leader laboratories in molecular magnetism, is the ideal place for its accomplishment because the large experience in molecular synthesis, including lanthanide chemistry, and the expertise in combining theory and experiment in the study of molecular-based magnets, in particular in SMMs and SCMs. Finally, the realization of the project will complement the theoretical and experimental expertise of the applicant in order to develop an independent career in theoretical aspects of molecular magnetism and it will afford him to establish contacts with other European research groups for future collaborations.",Theoretical basis for the design of Lanthanide-based molecular nanomagnets,FP7,05 February 2011,05 March 2009,154821.03 4NEDA,Politehnica University of Bucharest * Universitatea Politehnica din Bucuresti,information and communications technology,"The ToK - 4nEDA proposal aims to reinforce the competence in the area of High Performance Computing (HPC) hardware, software, and Grid middleware solutions at 'Politehnica' University of Bucharest, the best technical university in Romania. The transferred knowledge will be exploited by the local scientific community involved in a series of European research projects and multisectorial partnerships in the area of nanoelectronics. This interdisciplinary community committed to create an innovative platform for nano-Electronic Design Automation (nEDA). The local scientists have excellent result in their area of competence, however they need additional competencies in the complementary area of HPC, in order to fulfill their commitments with a relevant industrial impact. Tok will reinforce not only research, but also the capability of the host to provide training at the highest scientific quality. The research training in domain of Scientific Computation in Electrical Engineering (SCEE) and in broader area of Computational Science and Engineering (CSE), at all levels: Bachelor, Master, Doctoral, and post-doc will be improved. The proposal was designed to have optimal size: project duration of 4 years, providing in this period 3 fellowships. The in-coming experts will cover the local need of HPC-ToK, during their stay of 2 years each. The content, methodology and management of the ToK are defined considering the state-of-the-art, real need and feasible expected outcome. The proposal matches perfectly the action objectives, providing an important added value for the host and Community.",High Performance Computing Knowledge for nano-Electronic Design Automation,FP6,30 September 2010,01 October 2006,343803.71 ABLADE,University of Dundee,health,"This project aims develop an integrated laser diagnostic and therapeutic technique for the use in detecting and treating bladder cancer. The aim will be to transfer knowledge and expertise between the University of Dundee Medical School and the Photonics and Nanoscience Group and two industrial partners who have specific expertise in laser based medical diagnostics and system development to share in the research project. Key aims include the generation of in-vitro and in-vivo validation data for a newly discovered laser absorption, in response to cancerous cells, peak in the infra-red region . Uncovering the mechanism behind this strong biomarker and implementing the knowledge to develop a new diagnostic tool focussed on bladder cancer will also have long-term collaboration potential for early diagnosis of other types of cancer. ABLADE will aim is demonstrate the efficiacy of a novel photo-therapy based on the stimulation of triplet oxygen at a cellular level which can initiate cell apotosis specifically in tumour cells. The project high levels of transfer of knowledge and expertise, including access to leading research factilites, through a series of secondments of ESRs and ERs, complemented by the recruitment of ERs to provide further inter-disciplinarly expertise and resource while benefitting from the strong industrial and academic links initiated through the project.",Advanced Bladder cancer LAser Diagnostics and thErapy,FP7,09 April 2017,10 April 2013,2365400.0 ABREM,University of Brighton,health,"The main aim of this project is to establish a long-lasting collaboration and create a network of European and Chinese research centres of excellence and R&D active SMEs in the area of biomedical materials. This aim will be achieved by undertaking joint research activities in creating advanced composite 'hard' and 'soft' biomedical materials for regenerative medicine via collaboration facilitated by individual mobility of researchers between Europe and China. The main research objectives of the proposal are: - To synthesise novel composite carbon/carbon, carbon/polymer, polymer/polymer, carbon/ ceramic nanostructured biomaterials for advanced applications in regenerative medicine; - To characterise mechanical, physical and chemical properties of the synthesised biomaterials; - To produce bioactive materials which have bispecific surface functional groups, bioactive coating, carry bioactive agents, or carry induced pluripotent stem cells; - To assess their biological performance in clinically reflective tests; - To develop technologies for manufacturing novel biomaterials; - To gain fundamental knowledge of the mechanism of biomaterial -biological media interactions; - To develop novel biosensor devices for monitoring tissue engineered constructs; - To establish routes to market for the materials developed in this project.",Advanced Biomaterials for Regenerative Medicine,FP7,31 July 2015,01 August 2010,635400.0 ACAPOLY,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),manufacturing,"ACAPOLY is a partnership between micro resist technology GmbH and EPFL-LMIS1 whose main objective is the development of a new set of polymer materials for MEMS/NEMS technologies with an associated process library. The materials that the partnership has planned to develop are Ormocer and SU-8. The objective is to modify both materials in a way that they can be processed using Electron Beam Lithography, Direct Laser Writing, UV-Nano Imprint Lithography and Ink-Jet printing. The developed materials and process libraries will be used to fabricate UV-NIL stamps, large arrays of LEDs for automobiles and large arrays of optical waveguides.",Academia and Company collaboration and technology transfer in Advanced POLYmers,FP7,05 July 2014,06 January 2008,521706.0 ACCA,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"The ACCA will coordinate and integrate a harmonised R&D programme targeting new proactive initiative within FET with the focus on self-organisation of a network element's autonomic behaviour exposed by innovative (cross-layer optimised, context-aware, and securely programmable) protocol stack in its interaction with numerous often-dynamic network communities. The goals are to understand how desired element's behaviours are learned, influenced or changed, and how, in turn, these affect other elements, groups and network. Autonomic communication is centred around networking selfware - a novel approach to perform network control, management, middle box communication, service creation, etc. based on universal and fine-grained multiplexing of numerous policies, rules and events that is done autonomously but facilitates desired behaviour of groups of network elements. The R&D programme will identify sound approaches to develop autonomic communication spanning any transport, network and link technology and assisting true ambient intelligence. Relevant knowledge will be accumulated, evaluated and disseminated to both industry and research communities in a form of requirements analysis, white papers on architectural principles, problem statements, roadmaps, impact reports, etc. presented at targeted events. The ACCA will build an autonomic communication R&D community prepared to undertake practical steps in realising the R&D programme. Recognising that ACCA aims to solve the problem of communication infrastructure evolvability through self-organisation and that this research requires a broad interdisciplinary approach the Action will explore concurrently multiple paradigm spaces addressing the problem from the viewpoints of software and hardware developments, radio technology advances, design methodology, control theory, formal methods, distributed systems research, etc.",Autonomic Communication: Coordination Action,FP6,30 September 2006,30 September 2004,500000.0 ACCARC,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"Artificial metalloenzymes are expected to bring together the best of the two worlds of homogeneous and enzyme catalysis, combining broad substrate scope with high activity and reaction selectivity under mild conditions. Herein we propose to construct an artificial metalloenzyme based on a dirhodium active site in the capsid scaffold of the protein ferritin. Catalytically competent dirhodium compounds are derived from dirhodium tetraacetate, which possesses fourfold symmetry, with the ligands symmetrically arranged around the equator of the rhodium dimer. The transition metal core is active in a wide range of reactions including cyclopropanation, C-H activation and O-H insertion. These transformations play an important role in the synthesis of natural products, pharmaceuticals, and other industrially relevant targets. We will exploit the fourfold-symmetric pores of the capsidic protein ferritin to construct a dirhodium binding site. A ferritin mutant will be produced with four glutamate residues pointing in the channel lumen, suitable as ligands for the rhodium dimer. After derivatization with dirhodium the artificial capsid will be employed as a catalyst in organometallic reactions, such as the cyclopropanation of diaza carbonyl compounds with olefins in aqueous solution. The catalytic properties of this first dirhodium enzyme will be fine-tuned by the highly modular secondary ligand environment of the protein. The dirhodium binding site will also be introduced at the inner mouth of the fourfold channel, resulting in an active site inside the capsid. High local substrate concentrations and the presence of a second, complementary reaction center inside the capsid might allow multi-enzyme cascade catalysis, thus paving the way toward artificial nanoreactors with tailored properties.",Engineering of an Artificial Capsidic Enzyme for Aqueous Dirhodium Catalysis,FP7,31 March 2014,01 April 2012,192622.0 ACRES,Technical University of Denmark * Danmarks Tekniske Universitet,information and communications technology,"A novel system based on NEMS resonators will be developed. An array of coupled nanoresonators with a transduction based in the strain of thin layers of metal will be developed. To do that, analytical studies, FEM simulations, design and fabrication will be performed. The characterization will be done in three steps: measure frequency response of the system and characterization of the mass sensitivity (outgoing phase) and its use as a biosensor (return phase).",Array of coupled nanoresonators,FP7,04 March 2014,04 January 2009,258341.24 ACT,Philips Innovative Technology Solutions NV,information and communications technology,"We will explore advanced gate stacks for ultimate scaling of silicon based devices beyond the 45nm technology node. The firstobjective will be to find suitable metal oxide dielectric materials to replace the long standing silicon dioxide from the transistorgate. The materials must have a dielectric constant higher than 30 and a high thermal stability in contact with silicon, in orderto obtain equivalent oxide thickness (EOT) 0.5nm or lower. The second objective will be to develop appropriate models for theanalysis of the electrical data in order to extract accurate values of EOT, interface trap density, and flat band voltage shifts. Toachieve the objectives we have broken our workplan in four priorities which are: materials preparation; post-depositiontreatment; device fabrication and testing; data analysis. To implement the workplan we are going to exchange scientistsbetween the academic institution NCSR-'Demokritos' and the industrial organization Philips Research Leuven. Philips willlearn from 'Demokritos' about non-traditional material preparation methodologies based on molecular beam epitaxy(deposition) and structural characterization of metal oxides and interfaces. On the other hand NCSR will learn from Philipsabout fabrication and electrical testing of high-k devices. The immense interest of the industry in exploring new materials andassociated equipment at a low cost without disrupting the main process flow, guarantees that this collaboration will developinto a lasting strategic partnership.",Advanced Gate Stacks for CMOS Technology,FP6,30 April 2008,01 May 2004,163745.0 ACTECO,Europlasma NV,environment,"The objective of this IP is to support the less RTD intensive sectors of textile, biomedical and food industries in the development of more sustainable and safer processes through eco-innovation (new products and production systems). Plasmas are studied since years, but the main problem faced by this technology is the durability of the treatment. This project involves new plasma processes that are able to bring innovative properties with a lifetime close to the final products' one. This breakthrough will be achieved by developing existing knowledge in plasma processes and functional materials in combination with new plasma systems for nanotechnology. The ACTECO project will : - contribute to the modernisation of the industry and to the adaptation to the new economy, - substantially improve overall quality within the value chain, - minimise waste, use of hazardous substances and resource consumption. In this context, ACTECO addresses the objectives of the 3.4.3.3.1 workprogramme of the call. The objective-driven approach is mainly focused on new products by reaching hyper functional surfaces in association with the use of new plasma processes. The radical innovation is to provide new tools for an eco-production adapted to traditional sectors. The first phase of the workprogramme is related to Research at laboratory scale on the development and optimisation of the surface modification processes in constant interaction with an Equipment development activity. The second phase is focused on Applied Research by optimising existing prototypes at pilot scale. The new processes will be then developed through pre-industrial applications comparing the several facilities involved in the project (real devices and real environment). Both phases will be driven and monitored by market and consumer needs analysis, as well as by sustainability targets taking into account the economical, social and environmental impact.'",Eco efficient activation for hyper functional surfaces,FP6,30 April 2009,01 May 2005,4268248.0 ACTION-GRID,Technical University of Madrid * Universidad Politécnica de Madrid,health,"Topic: ACTION-Grid is a Specific International Cooperation Project on healthcare information systems based on Grid capabilities and Biomedical Informatics (BMI) between Latin America, the Western Balkans and the European Union (EU). Background: Members of the consortium have published pioneering scientific papers in Grid and BMI. They participated in the BIOINFOMED and SYMBIOMATICS studies that contributed decisively to the last two FPs of the EC. Main objective: ACTION-Grid will act as a multiplier of previous outcomes in Grid and BMI. ACTION-Grid will disseminate these outcomes in Latin America, the Western Balkans and North Africa. Subobjectives: (1) To survey Grid-based and BMI initiatives in Europe, Latin America, the Western Balkans and North Africa. These results will be combined with data from an inventory of Grid/Nano/BMI methods and services—, developed by the consortium. (2) Based on previous EC-based projects, ACTION-Grid will foster training and mobility in Grid and BMI. (3) To develop a White Paper, in collaboration with a panel of recognized experts. This document will be delivered to the EC to establish a future agenda covering the Grid/Nano/Bio/Medical Informatics areas and develop new plans in Latin America, the Western Balkans and North Africa. (4) To disseminate ACTION-Grid, by means of: (a) An international symposium on Grid and BMI. This conference will be carried out in Europe, with two satellite conferences (b) Scientific publications, (c) Dissemination strategies, such as a Website, Newsletters, Press releases, etc. Expected impact: To expand previous initiatives to create a common health information infrastructure in Europe, and extending it to other regions. It will enhance cooperation between research centres, universities, hospitals, SMEs, public entities, and others. ACTION-Grid will expand the impact of EC achievements in Grid and BMI to researchers, educators, and health practitioners world-wide.","International Cooperative Action on Grid Computing and Biomedical Informatics between the European Union, Latin America, the Western Balkans and North Africa",FP7,31 May 2010,01 June 2008,999077.0 ACTIVATION,Technical University of Crete,manufacturing,"Superhigh energy ball milling with the help of novel laboratory and industrial planetary mills will be applied for the development of new materials and technologies based on particle size reduction and mechanical activation of particles. Fundamental aspects of mechanical activation of materials will be studied. Improved performance of new materials will be achieved by means of finding an optimal balance between the size effects and effects of mechanical activation of particles. The specific feature of the project is the use of the planetary mills characterized by dramatically higher energy density than conventional milling equipment. The main groups of materials studied in this project would be hard alloys, intermetallics and composites, sialons and multicomponent ceramic oxides. Processing studies will be carried out for developing technologies and materials for applications in various industrial fields. Optimisation studies of the processing procedures and materials performance evaluation in the industrial environment will follow. The aims of the project include development of technologies providing high-volume production of nanoscale materials at low cost and technologies of recycling of solid materials in a fast, efficient and environmentally friendly process. Technological developments will exploit novel industrial planetary mills of continuous mode. Applications of the approach in various fields of industry including manufacturing of cutting tools, production of special refractories, production of advanced ceramics, development of hard thin coatings, development of improved thermal spray coatings, will be investigated.","Superhigh energy milling in the production of hard alloys, ceramic and composite materials",FP6,30 June 2007,01 July 2004,1999900.0 ACTIVATION OF XCI,Erasmus Universitair Medisch Centrum Rotterdam * Erasmus University Medical Center Rotterdam,health,"In mammals, gene dosage of X-chromosomal genes is equalized between sexes by random inactivation of either one of the two X chromosomes in female cells. In the initial phase of X chromosome inactivation (XCI), a counting and initiation process determines the number of X chromosomes per nucleus, and elects the future inactive X chromosome (Xi). Xist is an X-encoded gene that plays a crucial role in the XCI process. At the start of XCI Xist expression is up-regulated and Xist RNA accumulates on the future Xi thereby initiating silencing in cis. Recent work performed in my laboratory indicates that the counting and initiation process is directed by a stochastic mechanism, in which each X chromosome has an independent probability to be inactivated. We also found that this probability is determined by the X:ploïdy ratio. These results indicated the presence of at least one X-linked activator of XCI. With a BAC screen we recently identified X-encoded RNF12 to be a dose-dependent activator of XCI. Expression of RNF12 correlates with Xist expression, and a heterozygous deletion of Rnf12 results in a marked loss of XCI in female cells. The presence of a small proportion of cells that still initiate XCI, in Rnf12+/- cells, also indicated that more XCI-activators are involved in XCI. Here, we propose to investigate the molecular mechanism by which RNF12 activates XCI in mouse and human, and to search for additional XCI-activators. We will also attempt to establish the role of different inhibitors of XCI, including CTCF and the pluripotency factors OCT4, SOX2 and NANOG. We anticipate that these studies will significantly advance our understanding of XCI mechanisms, which is highly relevant for a better insight in the manifestation of X-linked diseases that are affected by XCI.",Molecular mechanisms controlling X chromosome inactivation,FP7,31 March 2016,01 April 2011,1500000.0 ACTIVE BIOMICS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The STREP proposed here deals with biomimetics at the supramolecular or subcellular level which covers the nano- and microregime. In this regime, biological systems exhibit many active processes which are driven by a variety of biomolecular nanomaschines or motors. The biomimetic systems studied in this STREP contain two types of linear motors, growing filaments and stepping motor proteins. Growing filaments generate pushing forces, stepping motor proteins exert pulling forces. The project has several scientific objectives: to understand the molecular processes which are responsible for the generation of these forces; to elucidate the cooperative behavior of small and large groups of motor molecules which lead to active surface layers and active filament assemblies or scaffolds; and to control and optimize the properties of these biomimetic systems. The research performed in this STREP is at the cutting edge of science and has a high potential for long-term innovation. Indeed, there are many possible applications in bioengineering, pharmocology, and medicine such as sorting devices for biomolecules and biocolloids, active drug delivery systems, and force generating components for the development of nanoscale manufacturing.",Active Biomimetic Systems,FP6,31 October 2008,01 May 2005,2150000.0 ACTIVE NANOPORES,Chalmers University of Technology * Chalmers Tekniska Högskola,photonics,"The project aims to develop, characterize and utilize nanopores functionalized with polymers. A new type of 'active' nanopores with incorporated metal film electrodes will be fabricated. In contrast to existing nanopores, this enables electrochemical control and plasmonic readout of the contents inside the pore. Parallel to fabrication and characterization of active nanopores, the project will investigate the behaviour of stimuli responsive polymers using electrochemical plasmonic sensors. Such polymers undergo conformational changes (phase transitions) in response to changes in the local environment (e.g. pH or temperature). The phase transitions can be induced by electrochemistry. By functionalizing the active nanopores with responsive polymers, the permeability of the pores can be controlled by simple electrical signals. This is because local changes in the chemical environment, induced by electrochemical potentials, can induce phase changes in the polymers. This leads to new applications such as tunable permeability and electrically controlled gating. The excitation of surface plasmons in the metal films offers the possibility to monitor nanopore functionalization and also to detect conformational changes in the polymers. It is explained how the CIG grant will strongly help the applicant to estblish independent, original and high quality research activities at the host. The applicant is currently starting his evaluation period of four years at the host. The grant will strongly improve the chances for the applicant to be integrated at the host and start a successful long lasting career.",Active Polymer-Functionalized Nanopores,FP7,31 July 2016,01 August 2012,100000.0 ACTIVE NEC,Tel Aviv University,energy,"The interaction between light and matter by creation of excitons (electron-hole pairs) provides one of the most common routes for generation of functional optical and electro-optical devices. These devices including lasers, detectors, biological markers, solar cells, etc., have great impact both on science, technology, and common wellbeing. In order to make better optical and electro-optical devices, i.e. more efficient, smaller and faster, it is highly important to find new and improved ways to focus, control, and couple light to optically active materials. One promising way to achieve it is by utilizing extreme plasmonic field enhancements on optical nanoantennas which have a dramatic effect on light-matter interaction. Here I propose to study experimentally and theoretically the use of advanced arrangements of optical nanoantennas that support extreme field enhancements to boost the interaction between light and excitons in nanoantenna-exciton-complexes (NECs). The first aim of this project is to use NECs to generate exciton-localized-surface-plasmon-polaritons (XLSP) operating at the strong and ultrastrong coupling regimes and to probe the intriguing associated physical phenomena. The second aim is to create novel ultrafast all-optical switches of XLSPs and to use them in different device applications. The third aim is to study for the first time stimulated scattering effects of XLSP and to demonstrate Bose-Einstein condensation of XLSPs in optical nanoantenna trap. The fourth aim is to combine the field of plasmonics with the emerging field of photon upconversion by sensitized triplet-triplet annihilation and to create NECs that support plasmon upconversion. This will lead to improvements of photon upconversion techniques and open door to new nanoscale energy converting devices. For the studies we will use advanced nanofabrication techniques and advanced experimental methods, including ultrafast probe beams, lifetime imaging techniques and near field nanoscopy.",Active Nanoantenna-Exciton-Complexes,FP7,28 February 2017,01 March 2013,100000.0 ACTIVENP,University of Linz * Johannes Kepler Universität Linz,photonics,"This project aims at designing novel hybrid nanophotonic devices comprising metallic nanostructures and active elements such as dye molecules or colloidal quantum dots. Three core objectives, each going far beyond the state of the art, shall be tackled: (i) Metamaterials containing gain materials: Metamaterials introduce magnetism to the optical frequency range and hold promise to create entirely novel devices for light manipulation. Since present day metamaterials are extremely absorptive, it is of utmost importance to fight losses. The ground-breaking approach of this proposal is to incorporate fluorescing species into the nanoscale metallic metastructures in order to compensate losses by stimulated emission. (ii) The second objective exceeds the ansatz of compensating losses and will reach out for lasing action. Individual metallic nanostructures such as pairs of nanoparticles will form novel and unusual nanometre sized resonators for laser action. State of the art microresonators still have a volume of at least half of the wavelength cubed. Noble metal nanoparticle resonators scale down this volume by a factor of thousand allowing for truly nanoscale coherent light sources. (iii) A third objective concerns a substantial improvement of nonlinear effects. This will be accomplished by drastically sharpened resonances of nanoplasmonic devices surrounded by active gain materials. An interdisciplinary team of PhD students and a PostDoc will be assembled, each scientist being uniquely qualified to cover one of the expertise fields: Design, spectroscopy, and simulation. The project s outcome is twofold: A substantial expansion of fundamental understanding of nanophotonics and practical devices such as nanoscopic lasers and low loss metamaterials.",Active and low loss nano photonics (ActiveNP),FP7,30 September 2015,01 October 2010,1494756.0 ACTOSPED,University of Strasbourg * Universitè de Strasbourg,photonics,"In this project, surface plasmon enhancement of emission from discrete active organic 1-D photonic nanostructures will be investigated as a means to enhancing the performance and electrical integration potential of miniaturized organic emissive devices. To this end, nobel metal (e.g., silver or gold) nanoparticles (NPs) which can support surface plasmons will be brought into close proximity (5 - 20 nm) to a light emitting conjugated polymer nanowire. The distance between the nanoparticle and the nanowire will be controlled using a dielectric spacer layer. Rational techniques for optically exciting and detecting plasmon resonances and surface plasmon meditated luminescence in the polymer nanostructures will also be developed. Enhancement of radiative and non-radiative decay rates in the emissive conjugated polymer as a function of metal-emitter separation distance will be studied. In addition, the emission intensity enhancement factor will be studied as a function of dipole orientation (i.e., molecular alignment) within the polymer nanowire. In addition, finite-difference time domain (FDTD) simulations of the electric field intensity generated by plane wave illumination will be used to obtain maps of the radiative decay rate enhancement of an organic nanowire near a small metal nanoparticle. The project will draw on core expertise of the researcher in organic active nanowire photonic devices and combine this expertise with the vast experience of the host groups at Caltech and University Louis Pasteur -Strasbourg in passive and active plasmonic devices. The organic plasmon enhanced photonic devices are likely to exhibit comparable performance, be of lower cost and be simpler to manufacture than their inorganic counterparts.",Active Organic Surface Plasmon Enhanced Nanophotonic Devices,FP7,08 December 2010,09 June 2008,200423.0 ADAPTIWALL,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,energy,"Achieving EU's energy-efficiency targets (2050 goals) depends on the right measures to retrofit existing building stock, which is dominated by residential buildings. Approximately 85% of the existing dwellings were built before 1990 with poor façade and roof insulation. Due to this weakness much energy is wasted when operating auxiliary heating, ventilation and air conditioning installations. Current retrofitting attempts by increasing envelope thickness bring negative consequences like too high airtightness, over-heating, poor ventilation and loss of space due to voluminous retrofit units. ADAPTIWALL solves this problem by using nanotechnology to develop a multifunctional and climate-adaptive panel for energy-efficient buildings. This novel panel consists of 3 elements: 1) lightweight concrete with nanoadditives for efficient thermal storage and load bearing capacity; 2) adaptable polymer materials for switchable thermal resistance; and 3) total heat exchanger with nanostructured membrane for temperature, moisture and anti-bacterial control. ADAPTIWALL panel is innovative due to its lightweight design and quick low-cost installation; switchable thermal resistance for heat exchange and storage; highly improved energy efficiency; and suitability to be used for façade or roof in cost-efficient retrofitting and new buildings in different European climate regions. When used for façades, ADAPTIWALL panels reduce the building's energy consumption by more than 50% in comparison with conventional retrofitting. Their ventilation and heat exchange properties significantly contribute to create a healthy and comfortable indoor climate, while eliminating the need for auxiliary installations. The ADAPTIWALL research project focuses on developing adaptive (nano)materials; applying the materials in a lightweight panel; enhancing the panel's structural, fire safety and sound insulation properties; and demonstrating the novel prefabricating systems to European construction industry.",Multi-functional light-weight WALL panel based on ADAPTive Insulation and nanomaterials for energy efficient buildings,FP7,31 August 2017,01 September 2013,3348164.0 ADAPTNANO,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),information and communications technology,"The aim of the project is a rational design of complex molecular self-assembled surface nanostructures the properties of which could be externally switched or their self-assembly process could be externally controlled. The project covers the research on the self-organization processes of molecules on metallic surfaces with ultra thin insulating layers and graphene substrates. Using the intermolecular bonds with graded strength the complex hierarchical architectures should be realized. The incorporation of switchable molecules gives the structures specific functional properties. The main idea lies in the preparation of nanopores which can be opened or closed through switching the molecules by light induced cis/trans isomeration which will be controlled by a proper choice of the used light wavelength. The detailed study of intermolecular interactions on insulating layers as well as understanding the light-induced switching processes in the nanostructures will be in centre of interest. Next, the influence of adjustable electronic density of graphene substrates or external electric fields on molecular self-assembly processes will be also studied.",Adaptive nanostructures prepared by hierarchical self-assembly,FP7,03 July 2014,04 January 2010,168969.0 ADEC,Danish Technological Institute * Teknologisk Institut,transport,"The consortium behind this project – a group of European SMEs, surface coating technology providers and engine manufacturers – aims at developing a new innovative type of super lubrication wear-resistant surface coating for internal walls within internal combustion engines.",Advanced Low Friction Engine Coating,FP7,12 July 2016,01 January 2013,0.0 ADELINE,Thales Avionics SAS,information and communications technology,"The objective of ADELINE is to develop new architectures and technologies of air data systems forimplementation in new aircraft on the horizon of 2010. Actual air data equipment is composed of a large number of individual probes and pressure sensors. This equipment delivers vital parameters for the safety of the aircraft's flight such as air speed, angle of attack and altitude. The loss of these data can cause aircraft crashes especially in case of probe icing. The main project targets are: - to reduce present equipment costs by 50 % including purchasing and exploitation costs, - to increase aircraft's safety by drastically reducing air data system failure. These targets will be achieved by developing simpler, more reliable and safer equipment than the American systems that dominate the market. The scientific objectives of ADELINE are: - Identification of innovative air data system architectures. - Development of innovative measuring concepts to acquire all information with only two different types of probes instead of 3 for competitors' solutions. - Development of breakthrough technologies: New probe material and associated nanomaterial coating in order to reduce abrasion and ice adherence. Innovative self regulated anti-icing technology based on the use of positive temperature coefficient (PTC)ceramics. New packaging technologies for MEMS pressure sensor to allow the integration of the sensor within the probe. - Development of a self-test for pressure sensor. To achieve these objectives, a consortium of 8 partners with all the required skills has been established asfollows: 2 SMEs, 1 industrial, 3 academic institutes and 2 research centres. The project is organised in 5 work packages which will allow: - the definition of the system architecture, - the development of innovative principles and technologies, - the development and the flight tests of 2 different functional mock-ups. The duration of the project is 36 months.",Advanced air-Data Equipment for airLINErs,FP6,14 May 2008,15 January 2005,2129617.0 ADMACOM,Polytechnic University of Turin * Politecnico di Torino,transport,The aim of ADMACOM (Advanced manufacturing routes for metal/Composite components for aerospace) is to develop innovative manufacturing technologies based on advanced design of interfaces and of joining materials for aerospace components.,Advanced manufacturing routes for metal/Composite components for Aerospace,FP7,09 June 2018,10 January 2013,0.0 ADMIENV,University of Cádiz * Universidad de Cádiz,environment,"The use of novel electron microscopy related techniques is necessary to understand the structure of modern catalysts and, as a consequence, to improve their performance. The installation and development in the University of Cadiz of two novel techniques, Electron Tomography and quasi in situ Microscopy will help to achieve this goal. Electron Tomography is able to unveil the three dimensional structure of functional objects, with sizes in the nanometer scale. This technique will be applied to the study of the morphology and crystallography of nanoparticles. Quasi in situ Microscopy allow the study of the structure and composition at subnanometric scale of different materials in particular chemical states after chemical reactions without being exposed to the atmosphere. These techniques will be applied to the study of catalytic systems based in cerium oxide with gold as the active phase main component used for selective oxidation of CO. New formulations will be tested, including mixed oxides as support and including a second metal in the active phase.",Advanced Electron Microscopy techniques applied to catalytic materials for energy generation with very low environmental impact.,FP7,03 March 2013,03 April 2010,45000.0 ADONIS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"Prostate Cancer is the most common cancer disease for men. The choice of treatment and its efficiency relies strongly on the stage in which the cancer is when diagnosed. Screening procedures like digital rectal examination (DRE) and free prostate specific antigene (PSA) level testing are well established but lack accuracy, yielding only 80 % of prostate cancers diagnosed in an early state. The objective of ADONIS is the proof of concept of using optoacoustic imaging in combination with biologically functionalized nanoparticles as an integrated biosensor based system for accurate diagnosis of prostate cancer. The idea behind ADONIS is to combine the superb biosensor selectivity of immunogold labelling with the peculiar optical properties of gold nanoparticles. It was recently shown that gold nanoparticles have very strong surface plasmon absorption of light that is sensitive to their shape and dimensions. The absorption of light from these localized absorption centers generates pressure waves, which propagate through the tissue to be detected and analyzed with techniques similar to conventional ultrasonic imaging. Exploiting this effect in combination with the possibilities of biological targetting of nanoparticles using a tumour marker like prostate specific membrane antigen (PSMA), the expected result is a new concept for biosensor based diagnosis of prostate cancer which will allow the development of overall accessible, cost-efficient medical instruments for accurate diagnosis.",Accurate Diagnosis of prostate cancer using Optoacoustic detection of biologically functionalized gold Nanoparticles - a new Integrated biosensor System,FP6,31 January 2009,01 November 2005,2229358.0 ADONIS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),energy,"New insight into ever smaller microscopic units of matter as well as in ever faster evolving chemical, physical or atomic processes pushes the frontiers in many fields in science. Pump/probe experiments turned out to be the most direct approach to time-domain investigations of fast-evolving microscopic processes. Accessing atomic and molecular inner-shell processes directly in the time-domain requires a combination of short wavelengths in the few hundred eV range and sub-femtosecond pulse duration. The concept of light-field-controlled XUV photoemission employs an XUV pulse achieved by High-order Harmonic Generation (HHG) as a pump and the light pulse as a probe or vice versa. The basic prerequisite, namely the generation and measurement of isolated sub-femtosecond XUV pulses synchronized to a strong few-cycle light pulse with attosecond precision, opens up a route to time-resolved inner-shell atomic and molecular spectroscopy with present day sources. Studies of attosecond electronic motion (1 as = 10-18 s) in solids and on surfaces and interfaces have until now remained out of reach. The unprecedented time resolution of the aforementioned technique will enable for the first time monitoring of sub-fs dynamics of such systems in the time domain. These dynamics -of electronic excitation, relaxation, and wave packet motion -are of broad scientific interest and pertinent to the development of many modern technologies including semiconductor and molecular electronics, optoelectronics, information processing, photovoltaics, and optical nano-structuring. The purpose of this project is to investigate phenomena like the temporal evolution of direct photoemission, interference effects in resonant photoemission, fast adsorbate-substrate charge transfer, and electronic dynamics in supramolecular assemblies, in a series of experiments in order to overcome the temporal limits of measurements in solid state physics and to better understand processes in microcosm.",Attosecond Dynamics On Interfaces and Solids,FP7,30 September 2013,01 October 2008,1296000.0 ADRENERGIC RECEPTORS,Paul Scherrer Institute,health,"Crystal structures of beta1 and beta2 adrenergic G protein-coupled receptors (GPCRs) have been determined recently. We propose to extend the structural information about this physiologically and medically important GPCR subfamily by obtaining the structures of the beta3 and the alpha adrenergic receptors. The ample experience in GPCR structural biology of the host laboratory, complemented by its multidisciplinary approach, provides an ideal environment for this challenging task. We will make use of high-throughput facilities and methods to optimize the receptor constructs for expression and protein stability. We will use various crystallization methods and available robotic nano-liter dispensers to determine suitable conditions for crystal growth. We will have access to state-of-the-art microcrystallography beamlines at the Swiss Light Source synchrotron at Paul Scherrer Institut (PSI) to test a large number of obtained crystals and collect the best possible diffraction datasets. Once diffraction data of sufficient quality has been obtained, the structure will be solved by molecular replacement. In collaboration with other PSI scientists and external academic and industrial partners we will use the structural results obtained for the adrenergic receptor subtypes to study the structural basis of ligand efficacy, i.e. how the process of ligand binding is translated into receptor function, and to find applications in therapeutic drug development.",Crystallization and structure determination of adrenergic G protein-coupled receptor subtypes,FP7,30 April 2013,01 May 2011,186028.0 ADVACT,Rolls-Royce Plc,information and communications technology,"Major strides have been made in monitoring and control for gas turbines engines. Very little has changed in what is physically controlled or the actuator mechanisms themselves. Variables on civil aircraft remain largely restricted to fuel input, guide vanes and bleed valves. All other components are designed as a compromise between efficiency at different operating conditions and the need to maintain stable operation over the entire operating range. Recent developments in available actuation mechanisms have been identified as providing many opportunities for new control functions that could provide a major step change in the capabilities of the machines. Internal company reviews and internationally reported programmes have identified many control functions and mechanisms that could be used. Just one application of these technologies has already been identified as saving 0.3M Euro per aircraft year on transatlantic flights and a fleet CO2 reduction of 8M Tonnes per year by 2020 There is a continual push to improve system performance for a number of commercial and legislative objectives. These can be largely grouped as cost, competitive position and environmental impact. Advanced Actuation will help to address these issues with improved engine performance. To achieve this there is a need for imaginative research into the basic technologies that have already been identified and extensive studies to consider the manufacturing, operational and environmental issues. The programme has three main elements; ? Quantify the performance and operational benefits of extended actuation capabilities. ? Research into selected technologies for the gas turbine environment ( MEMS, SMA, Advanced Electromagnetics, Boundary Layer Manipulation and Active Vibration Control). ? Evaluate the selected technologies in key applications (eg. variable nozzle, 'virtual' VGV, tip seals)",DEVELOPMENT OF ADVANCED ACTUATION CONCEPTS TO PROVIDE A STEP CHANGE IN TECHNOLOGY USED IN FUTURE AERO-ENGINE CONTROL SYSTEMS (ADVACT),FP6,31 December 2008,01 July 2004,4394886.0 ADVANBIOTEX,Universiteit Twente * Twente University,health,"The objective is to obtain knowledge-based textile materials with new functionalities and environmental responsiveness for advanced applications (e.g. medical, safety and care). This new material will change a number of specific properties in responce to variation of environment (PH and temperature). New functionalities will be implemented by appropriate surface modification (coating) of textile materials (cotton or/and polyester) with a thin layer of surface modifying system (SMS) based on biopolymer chitosan in its most adequate form (nano- or microparticles, emulsions, films and hydrogels). Chitosan can form environment-sensitive polymeric systems by various mechanisms of physical and chemical crosslinking with other polysaccharides or synthetic polymers. Currently known chitosan based SMS forms possess low mechanical strength and slow response times. Incorporation of SMS on textile fibre surface would give excellent strength and greatly reduced response times due to high active surface areas of the fibres. In response to an external stimuli, environment-sensitive SMS could drive the release of an active substance (drugs, fragrance, etc.), and hence give a new functionality to the textile material. The main challenges in achieving new textile material lay in finding the adequate form of effective surface modifying system (SMS) and increasing of surface adhesion of existing textile fibres in order to obtain durable coating. To improve the substrate's adhesive nature and enable subsequent coating with chitosan based SMS, the low temperature plasma (LTP) treatment will be used. The innovative textiles are of special interes for EU where the textile industry is intensively searching for new ways to enable the transition from resource-based towards knowledge-based production industry. The project will contribute the EU position in research in the emerging fields of functionalized coatings.",Advanced Functionality of Textiles by Biopolymer Surface Modification,FP6,14 December 2010,15 December 2006,1129530.75 AEROCAT,Technical University Dresden * Technische Universität Dresden,energy,"AEROCAT aims at the elucidation of the potential of nanoparticle derived aerogels in catalytic applications. The materials will be produced from a variety of nanoparticles available in colloidal solutions, amongst which are metals and metal oxides. The evolving aerogels are extremely light, highly porous solids and have been demonstrated to exhibit in many cases the important properties of the nanosized objects they consist of instead of simply those of the respective bulk solids. The resulting aerogel materials will be characterized with respect to their morphology and composition and their resulting (electro-)catalytic properties examined in the light of the inherent electronic nature of the nanosized constituents. Using the knowledge gained within the project the aerogel materials will be further re-processed in order to exploit their full potential relevant to catalysis and electrocatalysis. From the vast variety of possible applications of nanoparticle-based hydro- and aerogels like thermoelectrics, LEDs, pollutant clearance, sensorics and others we choose our strictly focused approach (i) due to the paramount importance of catalysis for the Chemical Industry, (ii) because we have successfully studied the Ethanol electrooxidation on a Pd-nanoparticle aerogel, (iii) we have patented on the oxygen reduction reaction in fuel cells with bimetallic aerogels, (iv) and we gained first and extremely promising results on the semi-hydrogenation of Acetylene on a mixed Pd/ZnO-nanoparticle aerogel. With this we are on the forefront of a research field which impact might not be overestimated. We should quickly explore its potentials and transfer on a short track the knowledge gained into pre-industrial testing.",Non-ordered nanoparticle superstructures -aerogels as efficient (electro-)catalysts,FP7,31 January 2019,01 February 2014,2194000.0 AEROCELL,Lenzing AG,energy,"The major goal of this project is to imagine, study, understand and develop a completely new ultra-light, nano or submicro-porous multifunctional materials (called Aerocellulose) from renewable natural polymers, mainly cellulose. Situated at the frontier of the knowledge in cellulose chemistry, cellulose physics, electrochemistry and aerogel science, this new material can only be developed because of the synergy of these scientific areas. The perspectives opened by the development of this class of ultra-light, huge specific surface, biodegradable, materials are tremendous (packaging, controlled release and delivery systems, electrochemical materials, fuel cell hydrogen storage, chromatography columns, thermal and acoustic insulation, plant growth supports, etc.). Aside a scientific paper reporting an attempt to prepare an aerogel from a cellulose derivative solution and a first successful preliminary test made end of 2002 by three of the partners to prepare a pure ultra light cellulose structure, this area is fully new, with no patent. This project has a very strong innovative character and is valuable contribution to a sustainable development.","Aerocellulose and its carbon counterparts - porous, multifunctional nanomaterials from renewable resources",FP6,31 December 2006,01 January 2004,2299376.0 AEROCOINS,Fundación Tecnalia Research & Innovation,construction,"In the context of global climate control policies, improving the energy efficiency of existing buildings represents a great challenge, worldwide as well as at the European level. Reducing the energy consumption of buildings is nowadays preferably achieved by increasing the thermal resistance of the insulation layer in the building envelope. The AEROCOINs project will make a significant contribution to the future reduction of energy consumption by decreasing heating and cooling demands of existing-buildings. A clever combination of sol-gel science and nanotechnology can greatly advance design and development of novel superinsulating aerogels. The AEROCOINs project proposes to create a new class of mechanically strong superinsulating aerogel composite/hybrid materials by overcoming the two major obstacles which have endured for so long and have prevented a more wide-spread use of silica-based aerogel insulation components in the building industry: i) strengthening of silica aerogels by cross-linking with cellulosic polymers or the incorporation of cellulose-based nanofibres and ii) lowering the production cost of monolithic plates or boards of composite/hybrid aerogel materials via ambient drying and continuous production technology. Acting on these two incentives, new superinsulating aerogel-based monolithic materials with improved thermo-mechanical properties will be synthesized at the laboratory scale, developed further to the pilot scale under the shape of superinsulating panels, integrated in well-suited envelope components which will then be used for energy and ageing evaluation purposes via the integration of the aerogel-based components in a demonstration wall. In addition, a complete LCA study of the component will be realized and a fabrication concept for cost effective mass production (based on a continuous elaboration process) will be laid out for further pre-industrial development",Aerogel-Based Composite/Hybrid Nanomaterials for Cost-Effective Building Super-Insulation Systems,FP7,06 March 2016,06 April 2012,3000000.0 AEROMUCO,Airbus Defence and Space GmbH,transport,"The main objective of the AEROMUCO project is to develop and evaluate a number of alternative – and highly innovative – active and passive multi-functional surface protection systems for future generation of aircraft, leading to a significant improvement in fuel efficiency and a reduction in CO2 and NOx emissions. Two technological routes to achieve this goal will be explored:",AEROdynamic Surfaces by advanced MUltifunctional COatings,FP7,04 June 2016,01 January 2011,0.0 AFFIRM,University College Dublin,health,"1.2 billion people worldwide lack access to safe drinking water. Drinking water quality is threatened by newly emerging organic micro-pollutants (pesticides, pharmaceuticals, industrial chemicals) in source waters. Nanofiltration is a technology that is expected to play a key role in future water treatment processes due to its effectiveness in removal of micropollutants. However, the loss of membrane flux due to fouling is one of the main impediments in the development of membrane processes for use in drinking water treatment. Currently there is a wholly inadequate mechanistic understanding of the role of biofilm on the fouling of nanofiltration membranes. Applying techniques including confocal microscopy, force spectroscopy, and infrared spectroscopy using an experimental programme informed by a technique known as scale-down together with mathematical modelling, it is confidently expected that significant advances will be gained in the mechanistic understanding of nanofiltration biofouling. The specific objectives are 1. How is the rate of formation and extent of such biofilms influenced by the biological response to the local microenvironment? 2 Elucidate the effect of extracellular polysaccharide substances on physical properties, composition and structure of these biofilms. 3: Investigate mechanisms to enhance biofilm removal by a physical detachment process complemented by techniques that alter biofilm material properties. A more fundamental insight into the mechanisms of nanofiltration operation will help in further development of this treatment method in future water treatment processes.",Analysis of Biofilm Mediated Fouling of Nanofiltration Membranes,FP7,30 September 2016,01 October 2011,1468986.0 AFTERTHEGOLDRUSH,Cardiff University,environment,"One of the greatest challenges facing society is the sustainability of resources. At present, a step change in the sustainable use of resources is needed and catalysis lies at the heart of the solution by providing new routes to carbon dioxide mitigation, energy security and water conservation. It is clear that new high efficiency game-changing catalysts are required to meet the challenge. This proposal will focus on excellence in catalyst design by learning from recent step change advances in gold catalysis by challenging perceptions. Intense interest in gold catalysts over the past two decades has accelerated our understanding of gold particle-size effects, gold-support and gold-metal interactions, the interchange between atomic and ionic gold species, and the role of the gold-support interface in creating and maintaining catalytic activity. The field has also driven the development of cutting-edge techniques, particularly in microscopy and transient kinetics, providing detailed structural characterisation on the nano-scale and probing the short-range and often short-lived interactions. By comparison, our understanding of other metal catalysts has remained relatively static.",Addressing global sustainability challenges by changing perceptions in catalyst design,FP7,03 July 2019,04 January 2012,0.0 AGATE,S.O.I.TEC Silicon on Insulator Technologies SA,photonics,"According to the High-Level Experts Group (HLG) micro and nanoelectronics are essential for all goods and services which need intelligent control in all innovative sectors and are therefore identified as Key Enabling Technologies (KET). Gallium Nitride is an advanced semiconductor material at the heart of three strategic issues, advanced materials, photonics and micro/nanoelectronics. The deployment of these technologies is key for Europe to strengthen its manufacturing capacities while addressing societal challenges on energy and transportation. The main goal of the AGATE project is to implement an industrial European source of engineered substrates and epitaxial structures for GaN electronic devices, and to validate the substrate performances on high performance GaN devices.",DEVELOPMENT OF ADVANCED GAN TECHNOLOGIES,FP7,31 March 2016,01 April 2013,8839423.0 AGATHA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The minority carrier diffusion lengths are small in polycrystalline or amorphous materials used in thin film solar cells, requiring thin layers to maximize charge collection. This is contradictory for the requirement to maximize solar energy absorption. The optical design consisting in increasing solar cell's light-trapping capability is of prime importance. In order to provide total internal reflection, both randomly textured surfaces and regularly patterned surfaces have been investigated. No one of these approaches provides optimal light trapping because no one is suitable for the broad solar spectrum. Recent approaches involving new TCO layers show that double textures provide improved scattering. The AGATHA project aims to realize an advanced light trapping design by combining micro-texturing of glass by hot embossing and nano-texturing of the top TCO layer by etching. The parameters of this 'modulated surface texture' can be adjusted to maximize the light scattering in all the solar spectrum to provide a significant increase in both short-circuit current and EQE. Suitable for high production throughput, the new texturation process chain developed in AGATHA fits with the intrinsic low cost nature of thin film solar cells To demonstrate the efficiency of this optical trapping design, the modulated texture concept will be implemented in a-Si:H based, µ-c-Si:H based and CIGS based thin films technologies. The objective is to reduce the active material thickness, from 250 nm up to 150 nm for the a-Si:H, from 1.5 µm up to 1 µm for µc-Si:H and from 2.5 µm up to 800 nm for the CIGS, when increasing the short circuit current of 15 % The choice of these technologies aims to maximize the impact by addressing 70% of the thin film market. According to typical solar cells cost structure, a 15 % reduction of the cost/m2 is achievable. Combined with the Jsc improvement, the implementation of modulated surface texture should result in a 20 % decrease of the €/W indicator. AGATHA is an EU coordinated project in the framework of call FP7-ENERGY-2010-INDIA, foreseeing a simultaneous start with the Indian coordinated project. Accordingly, the Indian project should start at the latest within 3 months of the signature of the EU grant agreement.",Advanced Gratting for Thin Films Solar Cell,FP7,31 August 2016,01 September 2010,1708420.0 AGGLONANOCOAT,Technische Universiteit Delft * Delft University of Technology,health,"This proposal aims to develop a generic synthesis approach for core-shell nanoparticles by unravelling the relevant mechanisms. Core-shell nanoparticles have high potential in heterogeneous catalysis, energy storage, and medical applications. However, on a fundamental level there is currently a poor understanding of how to produce such nanostructured particles in a controllable and scalable manner. The main barriers to achieving this goal are understanding how nanoparticles agglomerate to loose dynamic clusters and controlling the agglomeration process in gas flows during coating, such that uniform coatings can be made. This is very challenging because of the two-way coupling between agglomeration and coating. During the coating we change the particle surfaces and thus the way the particles stick together. Correspondingly, the stickiness of particles determines how easy reactants can reach the surface. Innovatively the project will be the first systematic study into this multi-scale phenomenon with investigations at all relevant length scales. Current synthesis approaches -mostly carried out in the liquid phase -are typically developed case by case. I will coat nanoparticles in the gas phase with atomic layer deposition (ALD): a technique from the semi-conductor industry that can deposit a wide range of materials. ALD applied to flat substrates offers excellent control over layer thickness. I will investigate the modification of single particle surfaces, particle-particle interaction, the structure of agglomerates, and the flow behaviour of large number of agglomerates. To this end, I will apply a multidisciplinary approach, combining disciplines as physical chemistry, fluid dynamics, and reaction engineering.",The interplay between agglomeration and coating of nanoparticles in the gas phase,FP7,30 November 2016,01 December 2011,1409952.0 AIQT,University of Sussex,information and communications technology,"Quantum mechanics will enable powerful applications due to the emergence of new quantum technologies such as the quantum computer. While such a device will likely provide ground breaking commercial and national security applications due to the existence of powerful algorithms, its existence will revolutionize modern day science by allowing true quantum simulations of systems that may be modelled classically only insufficiently due to an in-principle limitation of current computer technology. Recent progress in experiments with trapped single atomic ions shows that it should be possible to build a quantum computer using this technology. A major challenge is the scaling of already existing technology beyond a token number of quantum bits. This research will address the manipulation of single atoms in complicated arrays as an architecture for a quantum computer and furthermore, will aim to allow for unprecedented motional control of a large number of single atoms inside such arrays. Single atomic ions will be trapped using electric fields, shuttled inside a complicated array of trap electrodes and manipulated using laser beams. We will develop architectures for the implementation of an ion trap quantum computer by developing nano- and micro-fabricated structures using techniques from micro-electromechanical device engineering. We will develop techniques to retain and control atoms during shuttling operations along complicated paths inside the array and we will develop protocols to control a large number of quantum bits in such arrays. We will also develop optimized ion trap geometries that allow for simple transport of atomic ions in multi-dimensional arrays.",Architectures for ion quantum technology,FP6,31 March 2009,01 April 2007,80000.0 AIRMINWATSFG,Stichting voor Fundamenteel Onderzoek der Materie (FOM) * Foundation for Fundamental Research of the Matter (FOM),environment,"Molecular level descriptions of the structure and dynamics of water and the hydronium ion are essential to understand quantitatively the dispersion of contaminants in groundwater, the role of aqueous aerosols in atmospheric chemistry and the optimal design of biomaterials. The structure of water and the stabilization of the hydronium ion at interfaces is a function of a hydrogen bond network. Each hydrogen bond in the network breaks and reforms on picosecond timescales. Current work describes structure in these systems by measuring the interfacial water and hydronium OH stretch frequency range using vibrational sum frequency spectroscopy (VSFS). Generally VSFS is time averaged: each data point in a spectrum involves several seconds of data collection. This approach necessitates loss of molecular information (in reality water structure evolves on picosecond timescales) and makes comparison to simulation, where trajectories have a maximum length of tens of nanoseconds, challenging. The proposed experiments overcome this obstacle by examining the air/water and mineral/water systems using femtosecond time resolved two-dimensional VSFS (tr2D-VSFS). This method allows the quantification of hydrogen bond (as a function of frequency) and hydronium lifetime in interfacial water. The measurement of these quantities at a variety of interfaces will allow general insight into the structure of aqueous complexes at interfaces, directly connect with simulation and help supply an experimental molecular level picture of the air/water and mineral/water intefaces that has been lacking. tr2D-VSFS is a specialized technique (employed currently by 1-2 research groups in the world). The impact of this proposal rests on the combination of an Earth Scientist with a peculiar background (nonlinear optics and computational chemistry), a host research group at the forefront of chemical physics and a host institute well prepared to support such a multidisciplinary collaboration.",Structure and Ultrafast Dynamics of Water and the Hydronium Ion at the Air/Water and Mineral/Water Interfaces using Time Resolved 2D-Vibrational Sum Frequency Spectroscopy,FP7,07 July 2012,08 January 2008,167697.15 AL-NANOFUNC,Consejo Superior De Investigaciones Científicas (CSIC),photonics,"The AL-NANOFUNC project has been designed to install and fully develop at the Materials Science Institute of Seville (ICMS, CSIC-Univ.Seville, Spain) an advanced laboratory for the Nano-analysis of novel functional materials. Advanced Nanoscopy facilities, based on latest generation electron microscopy equipments, will be devoted to breakthrough research in specific topics of high interest: i) Nanomaterials for sustainable energy applications; ii) protective and multifunctional thin film and nanostructured coatings; iii) nanostructured photonic materials and sensors. To take the ICMS laboratories to a leading position that is competitive in a world-wide scenario, the AL-NANOFUNC project is contemplated to up-grade the actual research potential in several directions: i) improve equipment capabilities regarding the Analytical High Resolution Electron Microscopy facilities; ii) improve the impact and excellence of basic research through hiring of experienced researchers and transnational exchange with the reference centers in Europe; iii) develop and improve the innovation potential of the ICMS's research by opening the new facilities to companies and stakeholders; iv) organize workshops and conferences, dissemination and take-up activities to improve research visibility. Close collaborations with reference centers and companies in Liège (Belgium), Graz (Austria), Jülich (Germany), Oxford (England), Cambridge (England), Dübendorf (Switzerland) and Rabat (Morocco), as well as with laboratories at Andalucian Universities, are foreseen in this project. Five companies in Andalusia will also collaborate in close synergies to promote the long-term strategic lines of interest for the region in the natural and artificial stone products and solar and renowable energy sectors.",ADVANCED LABORATORY FOR THE NANO-ANALYSIS OF NOVEL FUNCTIONAL MATERIALS,FP7,31 March 2015,01 October 2011,2687409.0 ALBATROSS,University College Cork,energy,"The proposal addresses each of the three elements of the so-called 'knowledge triangle', i.e. research, innovation and education. The proposed programme is based partly on nationally funded multidisciplinary (Photonics, Nanoelectronics, Chemistry, Materials Science) projects that have been recently awarded to the partners from Academia and is designed to provide added value from the obvious synergies between these projects. The complementarity will enable the consortium to develop novel products using SiO2/TiO2 nanoparticles for improving the properties of solar cells and OLEDs/ OFETs that the first SME partner aims to bring into production. The equipment innovation comes from the planned systematic modifications and improvements to both hardware and software and improvement to both hardware and software of a roll-to-roll Langmuir-Blodgett dipper mechanism that has been developed by the second SME partner. We aim at making the final device attractive for potential customers by modifying the existing prototype so that it is compatible with other equipment (LB troughs) aleady available on the market. The educational and training value of the project is also high in that a number of secondments of research personnel are envisaged, including PhD students. The enhanced commercial opportunities of the device will give the research community direct means of preparing complex photonic and nanoelectronic structures on flexible substrates using a wide range of materials. The innovative roll-to-roll (R2R) mechanism will therefore facilitate the possibility of using the LB technique in a range of new commercially scalable production processes, enabling us to take this technology out of the laboratory and into the factory environment - which will be a truly revolutionary accomplishment and one which is directly aligned with EU requirements.",Assembling Langmuir-Blodgett Architectures Through the use of Roll-to-roll Systems,FP7,31 March 2017,01 April 2013,844602.0 ALD4PV,Technische Universiteit Eindhoven * Eindhoven University of Technology,energy,"The proposal lies within the field of RENEWABLE ENERGY and aims to assist in achieving the EU climate and energy goals. Photovoltaics (PV) will have a significant impact on the energy market when the energy conversion efficiency of solar cells is enhanced. Most types of PV cells employ functional thin films and cell efficiency can be improved tailoring the properties of such films. Major challenges are to enhance photon absorption, reduce electron-hole recombination and improve charge transport. Atomic layer deposition (ALD) is an ultrathin-layer deposition technique well known for its excellent uniformity, conformability and composition control. Recently, this method has proven promising for PV through excellent surface passivation of crystalline Si cells by Al2O3. The full potential of ALD for PV cell manufacturing is yet to be exploited. This is why this project will explore the use of ALD-synthesized oxide films, in particular Zn-based and related oxides (In2O3, SnO2), for different types of solar cells. These films will be used as specific layers, such as tunnel layer in 1st generation crystalline Si cells; transparent conductive oxide or window layer in 2nd generation amorphous Si and CIGS thin film cells; and high surface-area photoanode in 3rd generation nano-based cells. After process development using various ALD configurations, different compositions and doping options will be investigated and characterised. The screening results will indicate the best candidates for conducting in-depth studies. Experimental and statistical techniques will be combined to establish the physical relationships between process parameters and film characteristics. Subsequently, optimisation and validation tests will be conducted through selected demonstrator experiments. The applicant is to attain total research autonomy and maturity at the end of the project. Transversal benefits for other energy devices (fuel cells, Li-ion batteries, etc.) are expected from this project.",ATOMIC LAYER DEPOSITION OF METAL OXIDES FOR PHOTOVOLTAIC SOLAR CELLS,FP7,03 February 2014,01 October 2011,184540.0 ALEXANDER,DECHEMA Gesellschaft für Chemische Technik und Biotechnologie eV,health,"The objective of the ALEXANDER project is the identification of novel strategies (e.g., proteolytic enzyme strategy, thiomer strategy, zeta potential changing systems, SNEDDS strategy) and the optimization of existing strategies (e.g., disulfide breaking strategy and slippery surface strategy) for the efficient transport of nanocarriers through the mucus gel layer (e.g., intestinal, nasal, ocular, vaginal, buccal, pulmonary). In particular, R&D activities will be focused on the synthesis of functionalized nanocarriers capable of permeating the mucus gel layer and delivering their therapeutic payload to the epithelium. The nanocarriers will be characterized with respect to their physicochemical properties, ability to cross the mucus gel layer, in vitro and in vivo cytotoxicity. The potential of the developed nanocarriers as delivery systems for mucosal administration of macromolecules will be demonstrated via the oral delivery of peptides, oligosaccharides and oligonucleotides and the nasal delivery of a plasmid encoding for an antigen.",Mucus Permeating Nanoparticulate Drug Delivery Systems,FP7,31 March 2016,01 April 2012,8098202.0 ALHSOLAR,University of Salento * Università del Salento,energy,"During last years, there has been a strong research effort in order to cut down photovoltaics costs. Several possible alternative technologies to silicon-based photovoltaics have been proposed and Organic PhotoVoltaics (OPV) could represent the cheapest way to convert solar energy into electricity. The Bulk Heterojunction (BHJ) solar cell represents a photovoltaic system that can be processed from solution leading to large area devices on transparent and flexible substrates, using cheap techniques like spin-coating, doctor blading, ink-jet printing and screen-printing, in conformity with the request of low cost photovoltaics. One major obstacle to be overcome is the low Power Conversion Efficiency (PCE) that has been demonstrated up to now, a maximum of about 5%. Various parameters influence the low efficiency: among the others, PCBM, a soluble fullerene derivative, is the almost exclusive n-type material (acceptor) in these devices, obliging to optimize the donor in a particular device configuration; only a little amount of the solar spectrum is involved in the energy conversion process; charge carrier mobility is lower than the one of inorganic counterparts, only partly balanced by a higher absorption coefficient and a higher charge mean lifetime. The major objectives to be achieved in the present proposal framework are: 1) to study the optical and the electronic properties of new low-bandgap materials, both polymers and inorganic nanoparticles, as donor phase to be used in BHJ solar cells; 2) to study the optical and electronic properties of inorganic nanoparticles to be used as acceptor phase in BHJ solar cells. 3) to optimize the device structure in order to increase the fraction of absorbed photons from the incoming solar photon flux studying the light harvesting by Resonant Surface Plasmon coupling; 4) to optimize the light harvesting by Resonant Energy Transfer and/or new conceptual spectral shaping.",Advanced Light Harvesting for Organic based Solar Energy Conversion,FP7,31 October 2012,01 November 2009,45000.0 ALIGNMENT-PROJECT,Aarhus University * Aarhus Universitet,information and communications technology,"The self-assembly method of organizing water-insoluble molecules on water surfaces into Langmuir films is a common way to fabricate ordered monolayers. However, the 2D crystalline films formed on the water are composed of many grains all lying on the same face, but oriented randomly azimuthally into and quot;2D powders and quot;. The crystallites have a diameter that ranges typically between 100-1500Ã…. Controlling the alignment and size of the growing 2D crystalline grains is the aim of this proposal. Ultimately, this would require grazing incidence X-ray diffraction techniques using synchrotron light and nonlinear optical techniques to detect and characterize the aligned crystalline mono- (or multi-) layers on the liquid surfaces. Due to its interdisciplinary character, the outcome of the project will be relevant to fields in physics, chemistry and biology. From a physics point of view, the development of nonlinear optical methods to induce alignment of molecules on the water surface is a direct continuation to problems in the coherent control domain, which in the field of molecule-alignment has been focused to date in the gas phase. The challenge is in the design of amphiphilic systems that will form aligned 2D crystals via the laser field and their detection. The success of the project will allow the preparation of significantly large 2D crystals and so provide a template for addressing questions in 2D-physics, interface physics, and chemistry and biology that occur at organic interfaces. In addition, it will provide new routes for the preparation of functional materials, especially in the nano-scale, which is of central interest in molecular electronics. In addition, it may be possible to fabricate new organic 2 and 3D multilayer crystals empoloying Langmuir-Blodgett methods. Finally, it may prove possible by this method to form large 2D crystals of membranal proteins that are very difficult to obtain as 3D crystals.",Aligning Amphiphilic Molecules on A Water Surface into Large Two-Dimensional (2D) Crystals by Laser Field,FP6,31 May 2009,01 June 2007,181268.66 ALISTORE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"Global warming, the finite nature of fossil fuels and pollution in our cities have conspired to make renewable energy a European imperative. It is clear that electrical energy storage is a critical issue for the new energy economy and one for which rechargeable lithium batteries, alongside other technologies, has an important potential impact. Although the rechargeable lithium battery, first introduced in 1990, is the most important advance in energy storage in 100 years, it has fallen short in meeting technological demands. Further breakthroughs are sorely needed. Europe is blessed with a number of internationally leading research groups working on lithium- ion batteries. These have shown that nano-materials have the potential to revolutionize battery design. However, if a substantial leap forward is to be made in performance, research into these complex systems requires that a range of skills and expertise must work together in an INTEGRATED network. Eighteen top research groups (from 7 member states and 3 candidate/associated members), accounting for about 70% of European Li battery research, are keen to merge their efforts WITHIN A VIRTUAL CENTRE to reduce redundancy, ensure complementarity, optimize collaboration to achieve vital research objectives, and share expensive facilities and resources, e.g., characterization platforms, pilot- plant battery fabrication. Innovative developments within Europe have all too often failed to realize their full potential through the inadequate size and disparity of individual research efforts. Integration will not only secure a sound scientific platform for battery research and training programs (European Masters degree, summer schools and workshops) to ensure long-lasting leadership but also provide, through the creation of an European Economic Interest Group, a more powerful and focussed mechanism for interacting with European industry and handling patent rights. Success in meeting the#",Advanced lithium energy storage systems based on the use of nano-powders and nano-composite electrodes/electrolytes (ALISTORE),FP6,31 December 2008,01 January 2004,5000000.0 ALLOPLASM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),photonics,"ALLOPLASM aims at the theoretical analysis and the experimental fabrication and characterization of liquid-crystal tunable long-range surface plasmon polariton elements. Conventional metal stripe plasmonic waveguides shall be enhanced with an electrically-switchable liquid-crystal superstrate layer. Through appropriate design, the electrical tuning of the LC-molecule tilting shall control the level of structural asymmetry and, therefore, the propagation properties, such as propagation constant and losses. The proposed structures shall be first theoretically analyzed and optimized by means of numerical tools, e.g. finite-element method, capable of addressing the anisotropic nature of the waveguiding structures. The derived structures shall be fabricated and optically characterized. Three types of end-components are targeted: a) a variable optical attenuator, b) a Mach-Zender interferometric modulator, and c) a directional coupler switch. Finally, the fabricated prototypes shall be packaged and pig-tailed, leading to compact electrically-tunable end-components. The fellowship aims to promote the career development of the fellow, who already possesses a strong theoretical background in optics, nanophotonics and nanomaterials, as well as in numerical tools needed to study the properties of optical waveguiding structures, which comprise both isotropic and anisotropic materials, such as liquid crystals. During this project he will receive complementary training in clean room fabrication processes, clean room processes specific to fabrication of liquid crystal guided optics devices, morphological investigation techniques, back-end processing and optical characterization of free space and guided optics devices. Training-by-research will provide him expertise in the entire chain of integrated optics devices.",tunAble Liquid-crystal LOng-range surface PLASMon polariton components,FP7,31 August 2013,01 September 2011,180084.0 ALLOXIDEPV,Bar-Ilan University,health,"The global market for photovoltaic (PV) cells that are converting sunlight into electricity almost doubled in 2010 to reach a massive 18.2 GW, nearly three times size of the market back in 2008. Crystalline silicon is the most common PV material today with a market share of more than 80%. New developments such as electrolyte based dye-sensitized solar cells as well as organic polymer cells have experienced remarkable progress in the laboratory but penetration into the market is still far away due to stability and sealing problems. Thus, this project will develop all-oxide photovoltaic cells based on nano-composite materials using combinatorial synthesis methods in conjunction with large throughput characterization and computational data analysis. Oxides are chemically stable, many of them are not hazardous, abundant and can furthermore be produced by low-cost methods. To challenge the inherent limitations of pure oxide semiconductors novel composite materials consisting of two or more pure metal oxides using various mixing ratios will be developed. Moreover, new fabrication techniques, powerful characterization tools and computational analysis methods will be employed that have not been available yet for material science. Combinatorial synthesis methods used in biology, chemistry and pharmaceutical research will be adopted to screen efficiently through a large amount of oxide compositions.",Novel Composite Oxides by Combinatorial Material Synthesis for Next Generation All-Oxide-Photovoltaics,FP7,31 October 2015,01 November 2012,2999674.0 ALLQUANTUM,Technical University of Denmark * Danmarks Tekniske Universitet,photonics,"In quantum electrodynamics a range of fundamental processes are driven by omnipresent vacuum fluctuations. Photonic crystals can control vacuum fluctuations and thereby the fundamental interaction between light and matter. We will conduct experiments on quantum dots in photonic crystals and observe novel quantum electrodynamics effects including fractional decay and the modified Lamb shift. Furthermore, photonic crystals will be explored for shielding sensitive quantum-superposition states against decoherence. Defects in photonic crystals allow novel functionalities enabling nanocavities and waveguides. We will use the tight confinement of light in a nanocavity to entangle a quantum dot and a photon, and explore the scalability. Controlled ways of generating scalable and robust quantum entanglement is the essential missing link limiting quantum communication and quantum computing. A single quantum dot coupled to a slowly propagating mode in a photonic crystal waveguide will be used to induce large nonlinearities at the few-photon level. Finally we will explore a novel route to enhanced light-matter interaction employing controlled disorder in photonic crystals. In disordered media multiple scattering of light takes place and can lead to the formation of Anderson-localized modes. We will explore cavity quantum electrodynamics in Anderson-localized random cavities considering disorder a resource and not a nuisance, which is the traditional view. The main focus of the project will be on optical experiments, but fabrication of photonic crystals and detailed theory will be carried out as well. Several of the proposed experiments will constitute milestones in quantum optics and may pave the way for all-solid-state quantum communication with quantum dots in photonic crystals.",All-solid-state quantum electrodynamics in photonic crystals,FP7,30 November 2015,01 December 2010,1199648.0 AM,University of Bristol,manufacturing,"Based on the work so far an exciting new area would involve PFS-b-PP (PP = polyphosphazene) block copolymers. These materials would possess a highly tunable inorganic PP coblock which is superficially reminiscent of PDMS. However, the PP block is inherently much more tunable allowing hydrophobic /hydrophilic or crystalline / amorphous or high Tg / low Tg substituents to be attached at will due to the subsitutive mode of synthesis form chlorinated PPs. This tunability, which far exceeds the that with polysiloxane blocks, will allow us to gain deep insight into the factors that facilitate self-assembly of block copolymers in solution and will also allow us to access stabilized nanomaterials for example by introducing crosslinking groups. The iron present in the PFS blocks will also help characterization as no staining agents are needed to visualize the PFS blocks using transmission electron microscopy.",Hybrid Organometallic-Inorganic Materials: Self-Assembly and Nanoscience Applications,FP6,31 July 2009,01 August 2007,159046.4 AMAAOOINCPOS,University of Leeds,health,"Recently, novel nanomaterials with unprecedented properties have attracted great attention, due to the rapid requirement of the emerging technologies in the fields such as biology and microelectronics. In this project, we proposed a novel kind of nanomaterials, organic/inorganic hybirds containing polyhedral oligomeric silsesquioxane (POSS). POSS-containing hybrid polymers with unique architectures will be prepared using advanced polymer synthesis protocols. These hybrid polymers could self-assemble into a rich variety of morphologies in domains with periodicities such as lamellae in bulk or micelle in solution. We will carry out primary test of the resulting POSS-containing nanomaterials for drug delivery applications and explore many other applications such as catalysis and nanoreactors, microelectronics, molecular template, etc.","Architectures, morphologies and applications of organic/inorganic nanomaterials containing polyhedral oligomeric silsesquioxane",FP7,02 January 2013,03 January 2011,240289.0 AMBIO,University of Birmingham,energy,"All structures in aquatic environments suffer from aggressive biofouling, which is economically costly, and its control imposes environmental burdens through release of biocides. Current non-biocidal coatings are unsuitable for most applications. Hence there is a 'technology gap' demanding innovation. The biofouling process involves interfacial interactions determined within a few nanomaters of a surface. Control of interfacial phenomena requires, therefore, a capability for molecular level engineering of surfaces. The goal of the AMBIO project is to develop innovative non-biocidal solutions to the problem of aquatic biofouling, using a range of molecular surface engineering approaches. The project integrates industries, universities and research organisations into a coordinated interdisciplinary programme incorporating all the necessary elements from nanomaterials engineering to biological evaluation and end-user trials. The industrial supply chain built into this IP will ensure durable impacts through technology transfer from the programme to industrial production. The project will use a 'knowledge-driven' research approach rather than empirical testing. Novel, nanoscale surfaces will be evaluated by biologists in rapid adhesion assays and characterised physically in terms of molecular orientation, conformation and surface dynamics. The results will be used to modify the models and refine the surfaces in an iterative approach. The most promising strategies will be developed as practical surfaces and subjected to field-testing of prototype products for end-use applications in the areas of hull coatings, membrane filters, aquaculture equipment, instrumentation, water-inlets and heat exchangers. The project will be Europe's first large-scale, multidisciplinary research programme to meet the problem of aquatic biofouling and thus will be a 'flagship' for European non-biocidal R&D.",Advanced nanostructured surfaces for the control of biofouling,FP6,28 February 2010,01 March 2005,1.1901786E7 AMETHYST,Pulse Medical Technologies Ltd.,health,"There are approximately 2 million people who suffer from chronic wounds such as venous leg ulcers in Europe at the present time. These wounds typically take between 12 and 24 weeks to heal, but 30% take over two years. This represents a cost to the European healthcare services of at least €8 billion a year in treatment. Two thirds of cases are released immediately for treatment in the community, and it is common for 40% of community nurses' time to be taken up by the management, dressing and care of this type of wound. In addition to the above, one of the reasons behind the phenomenon of antibiotic resistant bacteria is the widespread use of medication when there is no clinical infection. If low level silver ion dressings could be used in prophylaxis instead of antibiotics there would be an additional saving in terms of the cost of treating patients who contract antibiotic resistant infections. More importantly the incidence of antibiotic resistance will be lower. Current wound treatments are either expensive, inadequate or dangerous. Our idea provides a way of enhancing the effectiveness of silver-containing dressings used in the treatment of ulcers by creating a pulsed electromagnetic field at the wound site by the incorporation of a pulsed electromagnetic element in a low silver dressing. The pulsed electromagnetic field increases the concentration of silver ions available to the wound bed margin. The device is designed to be worn by patients in their every-day lives without the need to attend a medical facility for treatment. The system consists of two distinct components -an electronic pulse generator and an electromagnetic component contained in a disposable surgical dressing which is impregnated with silver-containing nanoparticles.",Ambulatory Magneto-Enhancement of Transdermal High Yield Silver Therapy,FP7,31 August 2013,01 November 2009,819104.0 AMI-4EUROPE,Madrid Network Association,health,"Thanks to the developments in Medical Imaging Diagnosis is earlier than ever. Physicians have more information and insight. Care is less invasive and less painful for patients. Access to tests and treatments is easier as imaging procedures are available in convenient settings, such as independent imaging centers. In addition, patient outcomes— from fewer complications to saved lives—are dramatically improved. And we are not at the end of our journey, yet!. The 'Next Generation' of Medical Imaging is just here out of the integration and cross-disciplinary use of NanoMedicine, Pharmacological breakthroughs, Biotechnologies for healthcare and ICT combined with standard Medical Imaging evolution. Unfortunately, the healthcare sector is quite diverse and collaboration has been difficult as a result, so the challenge is to build expertise in the development of integrated systems that address unmet clinical needs while providing a solid and consistent network of R&D + Innovation groups. Co-ordination and integration of Research-Driven Clusters under the so called 'Triple Helix III approach is a must in order to achieve the growth and competitiveness opportunities that Advanced Medical Imaging brings to the European society. AMI-4EUROPE is to co-ordinate, integrate and set up a newly defined EU-based Value Chain on Advanced, Cross-disciplinary and Integrated Medical Imaging by taking full advantage of all strengths that European stakeholders have while targeting the market niches that are arising as the Next Generation Medical Imaging unfolds itself out of the convergence of Nanomedicine, Pharmaceutical and Biotechnologies for healthcare and taking advantage of the ICT developments. Socio-economic impact at European level will be significant. Sustainability and synergy-searching are assured: Many regional governments are backing up AMI-4EUROPE.","Advanced, Cross-Disciplinary & Integrated Medical Imaging for all Europeans through a Network of Regional Clusters and Development Strategies",FP7,31 October 2013,01 October 2010,2649386.0 AMICOAT,Jallut Pinturas SL,health,"The objective of the project is to do research and development in formulation of new antimicrobial nanostructured durable coatings chemically grafted onto non nutrient chromate free primer of fuel tanks. The strategy to formulate these new antifouling coatings specifically designed to inhibit the adhesion of microorganisms will be based on two aspects that will take place simultaneously: physiochemical incompatibility between the surface of the coating and microorganisms and sub-products generated by them, and biochemical elimination of microorganisms to inhibit their adhesion to the surface of fuel tanks by a synergistic combination of inorganic and/or organic biocides embedded in the coating, including nanomaterials and micro- or nano-encapsulated chemicals. Surface morphology (SEM, AFM), surface chemistry (XPS), surface tension (contact angle), adhesion and durability of the new antifungal coating will be evaluated. The effect of growth inhibition for specific microorganisms present in aircraft fuel will be measured according to microbiological analysis and studies of formation, adhesion and elimination of biofilms onto the new developed antifouling surfaces. The new antifungal coating formulations will be compatible with fuel and will not affect fuel combustion. A special interest will be addressed to potential nano-safety and nano-toxicity issues.",Development of new antimicrobial nanostructured durable coatings for fuel tanks,FP7,31 May 2014,01 June 2012,224970.0 AMICOM,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"The approach of the information society has resulted in a tremendous increase in thevolume of wireless communication often giving rise to bottle-necks in the communicationsystems. To alleviate this congestion there is pressure to widen the allocated frequencybands up to millimetre wavelengths and to have terminals that are able to support manystandards. It is understood that conventional components and solutions have limitationsthat will make it difficult to fulfil these requirements. The last five years has seen theemergence of a technology, RF and microwave MicroElectroMechanical Systems (MEMS), thatseeks to overcome these limitations. In this new technology mechanical and electricalfunctions are combined to improve the performance of existing devices, allow on-waferdevice integration and the creation of completely new device systems called Advanced MEMSfor RF and Millimeterwave Communications 'AMICOM' .A consortium has been assembled that believes the merging MEMS technologies with 1Ctechnologies will lead to advanced microsystems that can operate over very broad-bandfrequency ranges. The microsystems will feature innovative functionalities, such ascircuit redundancy, reconfigurability and power management. To realise this microsystemconcept, research and collaboration in many different fields is required including!fabrication technology, materials, electromagnetics, mechanics, thermal and electricalmodelling, characterisation, packaging and reliability.We believe that a Network of Excellence is the most appropriate vehicle with whichto assemble and integrate the isolated competences that exist around Europe in thisfield. In this way a powerful research body will be created that can compete withthe United States and Japan. The idea is to give to the industrial partners accessto a large and transparent body of European competence to help them to enhancetheir competitiveness.",Advanced MEMS For RF and Millimeter Wave Communications,FP6,31 October 2007,31 December 2003,5499124.0 AMMAN,University of Cagliari * Università degli studi di Cagliari,manufacturing,"This proposal aims to apply advanced electron microscopy techniques to the study of magnetic nanocomposite materials, in particular sol-gel prepared FeCo oxide and alloy nanoparticles in silica and alumina matrices, which are promising for magnetic applications. These materials have previously been studied using detailed X-ray absorption spectroscopy measurements (in which the researcher was involved). However, there remain questions about variations in homogeneity of the nanoparticles, and the nature of surface oxide layers. Resolving these issues is central to understanding the material and apos;s behaviour, and advanced electron microscopy techniques are ideally suited for this. High resolution electron microscopy (HREM) of crystal grains will be used to observe differences between nanoparticles and to identify surface oxide layers. Electron energy loss spectroscopy (EELS) will be used to probe composition, oxidation state, and oxdie phases on the nm-scale. Finally energy filtered imaging will combine spatial and spectroscopic information to map variations in homogeneity on nm-scale. These will be state of the art measurements, making use of the host and apos;s excellent microscopy facility, and providing extremely valuable augmentation of the researcher and apos;s expertise in structural characterisation of novel materials.",Advanced Electron Microscopy Study of Magnetic Nanocomposites,FP6,03 January 2007,04 January 2006,96068.0 AMMSSTM,Institute of Applied Physics at University of Hamburg,information and communications technology,"This proposal links the postdoctoral stay of the candidate (coordinator) with the Scanning Probe Methods Group leaded by Prof. Roland Wiesendanger. This research group is hosted by the Institute of Applied Physics of the University of Hamburg (Germany). The group is part of the Microstructure Advanced Research Center Hamburg (MARCH) and is involved in the coordination of the German Center of Competence in Nano-Scale Analysis. Their scientific record in the field of nanometer-scale science and technology based on scanning probe methods (SPM) places the host organization in a world leading role in nanoscience. The current field of activity of the candidate is the spin-dependent transport in half-metals and several other magnetic nanostructures. Getting experience in low temperature SPM measurements is among his personal preferences, as well as one of the milestones of the newly created Institute of Nanoscience at his home University. The candidate and apos;s scientific background fits perfectly the profile of a post-doctoral fellow in the above mentioned research group. Such stay will not only provide a significant improvement of the scientific and technical skills of the candidate, but it will also conduct our interest in a possible collaborative research work on the frame of Spain-Germany integrated actions. We would like to express our interest in three possible research areas: -Measurements of the spin polarization of conduction electrons in magnetic materials by means of scanning tunnelling microscope (STM). -Determination of the magnetic and electronic properties in native iron oxides surfaces. -Layer by layer study of ferromagnetic films growth on top of semiconducting substrates. -Study of persistent spin polarized currents in semiconducting collectors of spin injection devices.",Characterization of Advanced Magnetic Materials for Spintronics by means of Scanning Tunneling Microscopy and Spectroscopy,FP6,31 January 2009,01 February 2007,149722.0 AMOCROSS,Stichting voor Fundamenteel Onderzoek der Materie (FOM) * Foundation for Fundamental Research of the Matter (FOM),photonics,"The aim of the AMOCROSS project is to provide high-level interdisciplinary training to early-stage researchers at the interface of three emerging fields: nanophotonics, femtophysics and mesoscopic biophysics. Europe has a strong, often leading, position in these strategic fields of science. Purely mono-disciplinary training will not provide the best preparation for young scientists who will form the core of the future knowledge-based economy. For this reason, an early-stage training program is offered that is, from the start, interdisciplinary. In practice, this means that the trainees will work on a research project that bridges at least two of the three topics listed above. The FOM Institute AMOLF in Amsterdam has structured its research in large research units. Individually, each unit aims to be at the forefront of its own core field – yet the day-to-day research is strongly linked to that of the other units. AMOLF has an active interaction with industry; one AMOLF group is even located at Philips Research and AMOLF aims to extend industrial collaborations of this kind. The aim is to offer young scientists the experience of working in such a dynamic, competitive interdisciplinary environment. The three fields mentioned above are related by the techniques and methods employed. The research in the fields covered by the program offers exciting scientific challenges with clear technological implications. Comprehensive research lines are offered on three topics, each of which contains two projects that link two of the three research fields. One aim of the cross-training experience at AMOLF is to show prospective students that these research fields and their future applications should never be seen in isolation. To emphasize the importance of “consolidating†experimental observations in a theoretical framework, the experimental training is integrated with a theoretical/numerical modeling program. At AMOLF, these activities are closely coupled.","AMOLF integrated training in nanophotonics, femtophysics and mesoscopic biophysics",FP6,31 December 2009,01 January 2006,999250.4 AMON-RA,Lund University * Lunds Universitet,energy,"The proposed project AMON-RA (Architectures, Materials, and One-dimensional Nanowires for Photovoltaics -Research and Applications) is intended to result in a new type of solar cell, combining advanced hetero- and nano-structures with silicon photovoltaic technology. By ap-plying state-of-the-art photovoltaics design to semiconductor nanowires and nanotrees and assisted by tailor-made theoretical modeling and advanced processing, we aim to demonstrate high-efficiency multi-junction photovoltaic cells made from previously impossible materials combinations. The high degree of self-assembly and insensitivity to lattice parameters inherent in the nanowire growth process will also make it possible to produce such cell relatively cheaply and on inexpensive silicon substrates. In AMON-RA, we will also evaluate the solar cell designs on a systems level, with special attention to future industrialization and upscaling.","Architectures, Materials, and One-dimensional Nanowires for Photovoltaics - Research and Applications",FP7,30 September 2012,01 October 2008,3199987.0 AMORPH,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),construction,"Currently, the annual global cement production is estimated to be 3.3 billion tons1. Even though the CO2 emissions associated with the final product, concrete, are low, the massive scale of production, means that the cement industry accounts for 5-8 % of the global annual anthropogenic CO2 emissions3. One of the most effective ways to improve sustainability is the blending of Portland cement with supplementary cementitious materials (SCMs)2,3. However many local sources are fully exploited and a decline in production of blastfurnace slags and fly ash is expected due to future developments in steel and electricity production4. Therefore locally available alternatives to these traditional SCMs need to be found to achieve higher cement replacement levels and a more sustainable cement industry.",Analysis and Modelling of the Reactivity of Pozzolans during Cement Hydration,FP7,05 July 2016,06 January 2012,0.0 AMPHIDRUGS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Among the numerous classes of drug delivery systems, drug-loaded polymer nanoparticles have attracted much attention. Although this approach has led to numerous encouraging results and proofs of concept in vitro, important limitations still remain, which may explain the lower number of successful in vivo studies and the limited number of marketed nanomedicines. In this view, the current project aims at developing an innovative and versatile nanoparticulate platform to prepare well-defined amphiphilic polymer-drug 'prodrug' nanoassemblies by means of controlled/living radical polymerization (CLRP) techniques, such as nitroxide-mediated polymerization (NMP), atom transfer radical polymerization (ATRP), or reversible addition-fragmentation chain transfer (RAFT). The new, facile and general strategy we propose relies on the controlled growth of biorelevant polymers (hydrophobic or hydrophilic) from functionalized drugs of the opposite solubility under CLRP conditions. This will result in well-defined amphiphilic species, bearing one drug molecule at the extremity of each polymer chain, able to self-assemble into nanoassemblies of various morphologies, exhibiting high drug payloads and thus high biological activities. This new methodology tends to be: (i) universal as it is virtually applicable to multiple drugs and consequently to multiple pathologies and (ii) versatile as various polymer prodrugs can be produced with high degree of control and flexibility over their structures (e.g., nature of the drug/polymer couple, nature of the linker, polymer chain length, etc.). This will be illustrated by the synthesis of a broad range of polymer prodrugs from a wide selection of drugs having demonstrated activities against cancer. Comprehensive characterization of the resulting nanoassemblies will be performed as well as their pharmacological evaluation in vitro (cell culture) and in vivo on relevant models, according to standardized protocols.",Anticancer nanoparticles from amphiphilic macromolecular produgs,FP7,30 April 2016,01 May 2014,202405.0 AMPRO,Imperial College London,photonics,"I propose a structured multidisciplinary research programme that seeks to combine advanced materials, such as metal oxides and organics, with novel fabrication methods to develop devices for application in: (1) large area electronics, (2) integrated nanoelectronics and (3) sensors. At the heart of this programme lies the development of novel oxide semiconductors. These will be synthesised from solution using precursors. Chemical doping via physical blending will be explored for the tuning of the electronic properties of these compounds. This simple approach will enable the rapid development of a library of materials far beyond those accessible by traditional methods. Oxides will then be combined with inorganic/organic dielectrics to demonstrate low power transistors. Ultimate target for application area (1) is the development of transistors with hole/electron mobilities exceeding 20/200 cm^2/Vs respectively. For application area (2) I will combine the precursor formulations with advanced scanning thermochemical nanolithography. A heated atomic force microscope tip will be used for the local chemical conversion of the precursor to oxide with sub-50 nm resolution. This will enable patterning of nanostructures with desirable shape and size. Sequential patterning of semi/conductive layers combined with SAM dielectrics would enable fabrication of nano-sized devices and circuits. For application area (3), research effort will focus on novel hybrid phototransistors. Use of different light absorbing organic dyes functionalised onto the oxide channel will be explored as a mean for developing high sensitivity phototransistors and full colour sensing arrays. Organic dyes will also be combined with nano-sized transistors to demonstrate integrated nano-scale optoelectronics. The unique combination of bottom-up and top-down strategies adopted in this project will lead to the development of novel high performance devices with a host of existing and new applications.",Advanced Electronic Materials and Devices through Novel Processing Paradigms,FP7,31 December 2016,01 January 2012,1497798.0 AMSCOPPER,"Centre for Research & Technology, Hellas * Ethniko Kentro Erevnas Kai Technologikis Anaptyxis (CERTH)",health,"Infection prevention measures aim to ensure the protection of people who might be vulnerable to acquiring an infection both in the general community and while receiving care due to health problems. The basic principle of infection prevention and control is hygiene. Hygiene could be divided in personal hygiene (e.g. hand washing) and inanimate object disinfection (e.g. use of chemicals for cleaning and sanitizing). However, hygiene practices is not enough to fight against infections. Indeed, the estimated annual cost of medical care for treating infectious diseases in Europe is about €120 billion while HealthCare Acquired Infections are directly responsible for approximately 37,000 deaths annually and contribute to a further 110,000 across the EU. This is because, every person comes in contact several times per day with bacteria via touching inanimate objects such as handrails, shopping carts, door knobs etc and thus, the hazard of infections is more than evident. In order to overcome this important social problem, the SMEs participants propose a novel solution to be used against diseases transmission: The application of new copper based coatings in metallic objects with photo-catalytic imposed anti-microbial and self cleaning activity. These new composite coatings will consist of a copper matrix and chemically modified TiO2 nano-particles as reinforcing mean, and will present enhanced photo-catalytic activity under visible light irradiation. They will be applied in various metallic objects such as handles, door knobs or rails, which can potentially be reservoirs of communicable viruses, and thus will lead to a decrease of the risk of getting infected by a factor of >50%.","Anti-microbial, self-cleaning copper composite coatings applied in metallic objects against infections transmission",FP7,30 November 2015,01 December 2013,1111000.0 AMYTOX,University of Leeds,health,"Despite the discovery of amyloidosis more than a century ago, the molecular and cellular mechanisms of these devastating human disorders remain obscure. In addition to their involvement in disease, amyloid fibrils perform physiological functions, whilst others have potentials as biomaterials. To realise their use in nanotechnology and to enable the development of amyloid therapies, there is an urgent need to understand the molecular pathways of amyloid assembly and to determine how amyloid fibrils interact with cells and cellular components. The challenges lie in the transient nature and low population of aggregating species and the panoply of amyloid fibril structures. This molecular complexity renders identification of the culprits of amyloid disease impossible to achieve using traditional methods. Here I propose a series of exciting experiments that aim to cast new light on the molecular and cellular mechanisms of amyloidosis by exploiting approaches capable of imaging individual protein molecules or single protein fibrils in vitro and in living cells. The proposal builds on new data from our laboratory that have shown that amyloid fibrils (disease-associated, functional and created from de novo designed sequences) kill cells by a mechanism that depends on fibril length and on cellular uptake. Specifically, I will (i) use single molecule fluorescence and non-covalent mass spectrometry and to determine why short fibril samples disrupt biological membranes more than their longer counterparts and electron tomography to determine, for the first time, the structural properties of cytotoxic fibril ends; (ii) develop single molecule force spectroscopy to probe the interactions between amyloid precursors, fibrils and cellular membranes; and (iii) develop cell biological assays to discover the biological mechanism(s) of amyloid-induced cell death and high resolution imaging and electron tomography to visualise amyloid fibrils in the act of killing living cells.",Amyloid fibril cytotoxicity: new insights from novel approaches,FP7,30 April 2018,01 May 2013,2498465.0 ANASTASIA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The objective is to develop radically innovative electrical insulating tapes and process to improve the energy conversion efficiency of electrotechnical systems. It mainly addresses the electric power generation issue. Today, the energy conversion efficiency of generators is restricted by (i) thermal as well as (ii) electrical strength limitations due to the electrical insulator tapes themselves. The concepts of these multifunctional tapes are far behind the electrical insulating state of the art. The project aims to develop a new process chain leading to a drastic improvement of insulating tape structure homogeneity. The today's limitations of tape come from its heterogeneous multilayer structure bringing together very different materials like glass fibre fabric, mica flakes and polymers. Enabling this homogenisation requires higher performance materials, which will be obtained by adjunct of inorganic nanofillers according to two proposed development routes: nanodielectrics polymer or inorganic polymers (sol-gel). This will lead to a more robust process chain with a better productivity (+50%) and an insulating tape with enhanced performances like a higher field strength (+40%), a better thermal conduction (+60%). At the end, a much thinner tape (-30%) enabling the design of more compact generators is expected. This project can strongly impact the energy production field. For instance at the European scale, a +0.2% gain in generator conversion efficiency could save the equivalent of one nuclear power plant of 1000 MW (1.5 billions €), or nearly 10 fossil fuel power plants and related reduction in CO2 emission. It will also affect other very large markets like the industrial motor field using similar insulation tapes. The consortium of ANASTASIA project is equally composed of industrials and research laboratories, namely two manufacturers (tape and power generator), two generator end-users, four academic laboratories and the CEA research institute as coordinator.",Advanced NAno-Structured TApeS for electrotechnical high power Insulating Applications,FP7,31 December 2012,01 January 2010,3134676.0 ANDIST,University of Manchester,information and communications technology,"This proposal is aimed at understanding why nominally identical nanomagnetic elements switch at different values of applied magnetic field, and providing material solutions that will allow the switching field distribution (SFD) to be reduced. The width of the SFD is a critical problem in any nanomagnetic device that depends for its functionality on reversal of magnetisation, but is particularly pressing in the case of bit patterned media (BPM). BPM is currently a leading contender to become the new paradigm for data storage in the $30bn hard disk drive (HDD) industry when recording on granular, perpendicular media reaches its limit at ~1 Tbit/in2 (~155 Gbit/cm2). The timeliness and relevance of the proposed research is amply demonstrated by the realisation that the best current materials for BPM have an intrinsic distribution of anisotropy that is a factor of two greater than modelling shows is required to successfully build a BPM device operating at 1 Tbit/in2. BPM provides strong motivation of the proposed research, but the benefits for other areas of nanomagnetism are also significant, since it is generally true that as the size of nanomagnetic devices decreases the SFD increases. As an example, successful development of high density Magnetic Random Access Memory (MRAM) will crucially depend on control of the SFD. Hence, if the full potential of nanomagnetism as a practical technology is to be realised, control of the SFD will be a key enabling requirement. The research ideas contained in this proposal are firmly focussed on providing a new and detailed understanding of a critical problem in nanomagnetics. The principal investigator has a significant record of achievement in this important research area, gained while working in the US. The purpose of this re-integration proposal is to provide resources that will allow this extensive expertise and experience to be exploited to the full in a timely fashion.",Anisotropy Distributions in Nanomagnetic Arrays for Patterned Media,FP7,10 July 2014,11 January 2008,100000.0 ANDYHREP,Cancer Research UK,health,"Accurately copying its whole genome is perhaps the most important task of the cell. Mistakes in DNA replication can result in cell death or, potentially worse, in mutagenesis and genomic instability, which in turn can lead to uncontrolled proliferation, the basis of cancer. Elucidating the factors involved in DNA replication and understanding the mechanisms by which human cells guarantee the precise duplication of billions of base pairs and thereby appropriate proliferation are of utmost importance when aiming at defeating several diseases, among which cancer stands out as one of the leading causes of death in the world. While the actual enzymatic activity of DNA synthesis is accomplished by DNA polymerases, a remarkable set of extra factors is required for replication within the cell. Though the core replication components seem to be conserved from yeast to humans, in mammals the putative homologues of several key factors likely act with different mechanisms or have additional functions, as suggested by the low homology level and presence of extra domains. Thus, the object of my proposal is to identify novel factors involved in normal DNA replication progression and the response to replicative stress at the replisome level, specifically in human cells. I will put additional emphasis on elucidating the function of known metazoan-specific factors, which likely play a key role in the complex regulatory mechanisms required in higher organisms. To this end, I will combine various cutting edge methods, like nanobody-based sequential purifications, SILAC mass spectrometry and 3D-SIM microscopy, to develop assays to isolate active replisomes from human cells and study the identified factors mechanistically. This strategy will allow me to exploit and significantly expand my technical expertise and, complemented by the selected world-class host scientist and institute, to grow into an independent scientist and enhance Europe's research excellence.",Anatomy and dynamics of the human replisome,FP7,31 August 2016,01 September 2014,221606.0 ANGIOMATTRAIN,National University of Ireland Galway,health,"AngioMatTrain focuses on the comprehensive, multidisciplinary understanding of ischemic diseases, from basics to translation, fully supported by 8 full partners (5 universities, 1 hospital and 2 SMEs). This ITN will educate and train 12 Early Stage Researchers and 3 Experienced Researchers scientists in: tissue engineering, materials science, chemistry, functionalisation, cell biology, nanotechnology, bio-analytical techniques, animal models and prototype design. The researchers will undertake cross-disciplinary and intersectorial research projects, which when married together will deliver a novel, biomaterial-based, therapeutic device for the treatment of ischemic disease. 11 of the 12 ESRs will complete the AngioMatTrain PhD programme which is based on the promotion of knowledge through original research and is supported by additional discipline-specific and generic and transferable skills training. The research training programme is designed to ensure high-calibre graduates, best placed to secure employment in the private or public sector. Fellows will experience both private and public sector research and development environments through a considered secondment plan.",Development of Biomaterial-based Delivery Systems for Ischemic Conditions - An Integrated Pan-European Approach,FP7,30 April 2017,01 May 2013,3762537.0 ANIM,University of Bristol,health,"Recent advances made in the field of crystallization-driven self-assembly (CDSA) of block copolymers (BCPs) with a crystallisable core-forming block in selective solvents have opened up exciting opportunities in the creation of well-defined nanostructures such as monodisperse cylinders with precisely controlled length. Herein, we propose to study linear-dendritic BCPs and to obtain new, well-defined materials with the dimensional precision provided by CDSA and also higher orders of complexity arising from surface functionalization with dendrimers. The overall objectives of this proposal are two-fold. First, to combine well-defined dendrons with crystallizable linear blocks such as metal-containing polyferrocenylsilane (PFS) and crystalline biodegradable organic blocks such as polycaprolactone (PCL) and polylactide (PLA) to yield linear-dendritic BCPs to further advance fundamental knowledge by studying their self-assembly behavior. Second, by combining CDSA and dendrimer science we intend to take a significant step toward the creation of precisely surface-engineered materials for potential applications in nanomedicine. The proposed research objectives will be accomplished by bringing a highly talented researcher, Dr. Nazemi, from Canada with his extensive experience in dendrimer synthesis and bionanomaterials to stay for 2 years in one of Europe's highest ranked research laboratories, that of Professor Ian Manners at Bristol. This group is recognised as being among the world leaders in the fields of metallopolymers, BCP self-assembly, and in particular the use of CDSA. At the end of the 2 year stay Dr. Nazemi wishes to return to Canada to take up an academic position at a research-intensive University.","Precisely Defined, Surface-Engineered Nanostructures via Crystallization-Driven Self-Assembly of Linear-Dendritic Block Copolymers",FP7,30 April 2016,01 May 2014,231283.0 ANISOKINEQ,Complutense University of Madrid * Universidad Complutense de Madrid,manufacturing,The proposed research project aims to study,Equilibrium properties and kinetics of self-assembly of anisotropic colloids and molecular liquids,FP7,03 July 2016,04 January 2012,0.0 ANNA,Fondazione Bruno Kessler (FBK),information and communications technology,"The continuous scale reduction in micro and nanotechnologies that enables advanced micro and nanoelectronics is sustained by an intense worldwide R&D effort aimed and understanding and controlling materials properties and dimensions down to a near atomic level. Advances are critically dependent on the availability of appropriate tools for the characterization of electronic and optical properties, structure and composition of the materials used. New materials, ever smaller device dimensions and the demand of higher detection sensitivities pose huge challenges to the capabilities of current analysis equipment and expertise of analysts. They drive the quest for enhanced equipment performance and new methodology and process development. They also require the application of an increasingly wide array of analytical techniques in order to provide the necessary information. At present, European laboratories with core competencies in materials characterization and trace analysis operate largely independently. The ANNA project is a proposal to set up a collaborative, synergistic network of analytical scientists and institutions each with different but complementary competencies and analytical expertise to provide the integrated approach necessary to solve materials problems. The capabilities of such an Integrated Activity will be available to EU universities, research laboratories and industry. The instrument for this is an Integrated Infrastructure Initiative (I3) in which the activities are: a) networking in which ???golden' reference labs are formed and institutions and facilities are integrated to a analytical joint laboratory cluster; these laboratories are used as certified references and supply standardized methodologies; b) transnational access which enables access to the infrastructure offered by a number of partners; c) focussed joint research aimed at enhancing methods, assessment tools, preparation methodologies and evaluation systems and creating new knowledge.",European Integrated Activity of Excellence and Networking for Nano and Micro- Electronics Analysis,FP6,30 November 2010,01 December 2006,5655286.0 ANSWER,III-V Lab,energy,"The project ANSWER addresses the development of a new class of artificial materials for quantum cascade lasers. ANSWER is the response to fill the technological gap of semiconductor lasers in the 3-5/ym wavelength region. In this project we propose a nanotechnological solution based on large conduction band offset semiconductor heterostructures: These materials are needed for the realization of 3-5//m QC lasers. This wavelength region promises to bring substantial benefits to several important applications such as optical free-space communications and laser based spectroscopy for trace gas detection. These applications, that stand to improve Europe's social and industrial infrastructure, are undeveloped due to the lack of practical laser sources. The QC laser uses nanometer scale layers of semiconductor material to quantum mechanically engineer the electronic and optical properties of the device. This gives added functionality to these semiconductors, over and above their natural properties, and in this respect creates an artificial nanomaterial. Through this project we aim to advance Europe's leading position with regards to QC laser technology and thus create the foundations to stimulate future industrial development within the E.U. The consortium brings together some of the leading players in QC laser technology, who have a world class reputation, a proven research track record and a wealth of experience for QC laser development. The main project objectives are: 1 ) To make significant advances in the production of new large conduction band offset material platforms for QC lasers. 2) Assess new technologies and quantum designs for quantum cascade lasers in the 3-5µm gap. 3) Develop QC technologies that act as stepping stones towards 1.55µm emission wavelengths. The ultimate project deliverable is to produce a laser working under continuous wave (CW) operation, with simple thermoelectric cooling. High temperature #'",Artificial Nanomaterials for Short Wavelength Emission in the infraRed,FP6,31 January 2007,01 February 2004,1730046.0 ANTI-ANGIOGENIC DRUG,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"Angiogenesis a major contributor to tumor development and metastases. Formation of new blood vessels supports tumor proliferation and disease progression and is often associated with poor clinical prognosis. Recent advances targeting angiogenesis and inhibition of tumor neovascularization has led to the approval of several new antiangiogenic drugs for clinical use in many types of cancers. Yet despite promising potential, the efficacy of these treatments has been relatively limited. Additionally, as with chemotherapeutics, over time these therapies are associated with tumor resistance and escape. Antiangiogenic therapy (target-specific or broad spectrum) aims to eradicate the tumor by damaging its blood supply; as a result tumor tissue becomes hypoxic and, consequently, necrotic. By current clinical measure, this tissue death is considered a positive outcome; however it is recently discovered that the necrotic tissue in turn releases signals contributing to inflammation and angiogenesis, eventually initiating aggressive revascularization, overriding the foreseen beneficial effects of the antiangiogenic drug. For this grant, we propose to design a novel drug-delivery system based on multifunctional polymer nanomicelles which combine two small molecule drugs: one a potent antiangiogenic drug, and second which is an antagonist of these necrotic signals, combating the feed-back loop which can undermine the positive effects of therapy. Using this innovative approach, we intend to significantly improve cancer treatment by minimizing resistance to antiangiogenic drugs. This technology is based on our previous development of the PEG-PLA polymer conjugate of a small molecule angiostatic compound, TNP-470, which form nanomicelle with improved pharmacological properties compared with the free drug. By combining a second drug with distinct mechanism of action we will provide an important, clinically relevant tool, and a future platform for antiangiogenic or other drugs.",Multifunctional Polymeric Nanomicelles Combat Tumor Evasion in Antiangiogenic Cancer Therapy,FP7,30 April 2018,01 May 2014,100000.0 ANTICARB,University College London,health,"ANTICARB attempts to exploit the advantages offered by a novel nanotechnology platform -carbon nanotubes -and apply them to a clinically established therapeutic modality -targeted antibody therapy -for the creation of hybrid nanotechnology-based monoclonal antibody targeted cancer therapeutics. ANTICARB combines two emerging technologies, antibody and nanotube technology, in a way that will allow safe development of antibody-nanotube conjugates and explore their swift translation into a clinical oncology setting. By combining proven, clinically used, anti-cancer agents -antibodies -with a novel nanotechnology-based platform made of advanced nanomaterials, ANTICARB aims at enhancing the therapeutic potency of the antibody and establish a new paradigm for oncology therapeutics. The ability of carbon nanotube technology to transport antibodies into the tumor cell cytoplasm may lead to validation of specific intracellular targets for oncology. This objective will be reached by adopting a multidisciplinary approach and by bringing together expertise from the fields of drug delivery, molecular biology, chemistry, engineering, pharmacology and toxicology. The proposal capitalises on this industry-academia multidisciplinary and perfectly integrated team, whose expertise spans from advanced biotech to sophisticated nanotechnology.",Monoclonal ANTIbody-targeted CARBon nanobues against cancer,FP7,31 August 2011,01 March 2008,2967008.0 ANTOMIC,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),health,"The interaction of light with structures much smaller than its wavelength, i.e. far below the diffraction limit, is enhanced by the effect that electromagnetic fields cause in the charge of the object. The excitation of plasmons enhances and focuses the light in the proximity of the nanostructure, mediating the energy exchange between photons and electrons. As the size of metal nanostructures and optoelectronic nanodevices approaches atomic scale dimensions, quantization effects in their electronic and plasmon structure gain increasing relevance in light scattering. Understanding the coupling of photons with electrons in the presence of quantum effects is crucial for improving the functionality of optoelectronic nanodevices like light emitting diodes or for the performance of nanoparticles in fields like medicine, or catalysis. In this proposal we will study the quantum limits of light emission and scattering by metallic and molecular nanowires of nanometer sizes. We will identify their plasmon resonances and correlate them with their quantized electronic structure. The goal is to prove that nanowires of atomic sizes behave as optical antennas due to the quantization of their plasmon structure. This would mean that excitation of plasmon resonances can enhance the coupling between photons and electronic transitions in the nanowire. Since this research project bridges the fields of atomic-scale spectroscopy and nanooptics, a novel experimental approach is proposed. We will use low temperature scanning tunnelling and force microscopies, coupled to a light excitation and detection set-up, to resolve at the atomic scale both electronic structure and light scattering/emission by the atomic-sized antennas in response to optical/electron excitations. To enhance the field focusing at the quantum object we will use nanofabricated optical antennas as tips. An in-vacuum Fourier Transform detection scheme will be developed to extend the spectral detection to the mid-infrared.",Quantum nanoantennas for atomic scale optical spectroscopy,FP7,28 February 2018,01 March 2014,100000.0 ANVOC,Marmara Research Center,environment,"The abatement of the environmental problems is one of the biggest challenges of technology today. This requires investment in new and clean processes. The development and implementation of new production and separation processes may result in a green industrial revolution. Nanotechnology and membrane technology has many opportunities in this respect. Membrane systems offer lower costs, less maintenance, more flexibility, and significant environmental and product quality advantages than the conventional technologies and can be applied to a wide variety of industries. While membrane systems can perform difficult separations not possible with other technologies, nanotechnology gives new opportunities for cleaner production. Since the use of nanotechnologies and membrane technologies in industry is new, the end-users, located in the Associate Candidate Countries (ACC), have not yet compiled and homogenized information. There is a great need within the end users in the ACCs to be informed about the application areas, the type of applications, and organic compound separation, recovery and reduce. This will be achieved by means of a symposium and dissemination of results obtained so far. The symposium will lead to integrate the knowledge of excellent experts in this field. The aim of the project is to unify and coordinate the efforts of the scientists working in the Application of Nanotechnologies for Separation and Recovery of Volatile Organic Compounds from Waste Air Streams. These are planning to be performed via symposium activities. During these activites effect of integration of the knowledge of excellent experts in nanotechnologies, membrane technologies and air pollution prevention in the field discussed is planning to be accomplished. In practice this will be an attempt for effective cooperation of academic and scientific researcher from one side with industrial, national and local administration, from another side.",Application of Nanotechnologies for Separation and Recovery of Volatile Organic Compounds from Waste Air Streams,FP6,30 June 2005,01 July 2004,50000.0 AP-GAC,University of Oviedo * Universidad de Oviedo,manufacturing,"An exciting new area would involve PP block copolymers. These materials would possess an inorganic PP coblock which is superficially reminiscent of Polysiloxane. However, the PP block is inherently much more tunable. A key advantage is that whereas siloxane blocks are intrinsically highly hydrophobic, phosphazene blocks can be easily derivatized to allow them to become hydrophilic. This has the key advantage that self-assembly can be performed in water making processing and practical applications more realistic. This tunability of phosphazene blocks, will allow us to gain deep insight into the factors that facilitate self-assembly of block copolymers in solution and will also allow us to access stabilized nanomaterials for example by introducing crosslinking groups. The introduction of high crystallinity and/or chirality in the PP block will allow us to generate novel and interesting nanostructures.",SYNTHESIS AND SELF-ASSEMBLY OF POLYPHOSPHAZENE (PP) BLOCK COPOLYMERS. DESIGN OF NEW INORGANIC NANOSTRUCTURES DERIVED FROM HIGH CRISTALLINE OR/AND CHIRAL HIGH TUNABLE PP BLOCK,FP7,06 June 2015,07 January 2010,45000.0 APACOS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,photonics,"The APACOS project aims at developing solutions for the automated assembly of laser systems. The solutions include new laser sources designed for automated assembly, as well as an industrial micro assembly system that will be mechanically enhanced by an ultra-precise micromanipulator for additional degrees of freedom. Fully automated alignment and bonding strategies for optical components will be implemented in APACOS in order to prove the production concept. Therefore, two European SMEs from the laser manufacturing industry, Modulight and Altechna R&D, will develop novel laser sources with high market potential. Altechna aims at a high-power yellow laser based on OPSL technology with perspectives in the markets of health care and life sciences. Modulight pursues the development of a single-emitter based product platform for visible green and yellow lasers used for projection and display applications. The developments will be supported by the Optoelectronics Research Centre at Tampere University of Technology, a leading European research institution in the field of laser sources. SmarAct, an SME from Germany, is provider of precision technology such as multi-axes micromanipulators with nanometer precision. In APACOS a flexure-based micromanipulator will be integrated into an industrial micro assembly system by Rohwedder Micro Assembly, a company with long year experience in developing industrial micro assembly systems and also a partner in the project. The integration will mainly be carried out by the Fraunhofer-Institute for Production Technology IPT, a leading edge research institute in the field of automated laser assembly. For the development of automated alignment and bonding processes, the consortium sets up a process prototyping station with standard equipment and easy-to-use operator interfaces. A novel control concept for the production solution aiming at a high degree of reusability of process implementations will be worked out. The participation of FISBA OPTIK, a leading optics manufacturer from Switzerland with semi-automated assembly lines for optical sub-assemblies, completes the consortium. FISBA contributes valuable experience regarding automation-friendly component design and automated component handling. Together, the APACOS consortium strives for a more standardized and automated assembly of lasers and optical systems considering aspects of product design, production system requirements, and process development. That will lead to a set of design guidelines for laser sources and a flexible assembly cell for laser optics. The project results are expected to have a major impact on the European laser industry by strengthening innovative laser manufacturers through more competitive production conditions.",Automated Precision Assembly for Complex Optical Systems,FP7,31 July 2014,01 August 2012,1013999.0 APHOTOREACTOR,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,energy,"The proposal is built on the core idea to use an ensemble of multiple level self-organization processes to create a next generation photocatalytic platform that provides unprecedented property and reactivity control. As a main output, the project will yield a novel highly precise combined catalyst/photocatalyst assembly to: 1) provide a massive step ahead in photocatalytic applications such as direct solar hydrogen generation, pollution degradation (incl. CO2 decomposition), N2 fixation, or photocatalytic organic synthesis. It will drastically enhance efficiency and selectivity of photocatalytic reactions, and enable a high number of organic synthetic reactions to be carried out economically (and ecologically) via combined catalytic/photocatalytic pathways. Even more, it will establish an entirely new generation of '100% depoisoning', anti-aggregation catalysts with substantially enhanced catalyst life-time. For this, a series of self-assembly processes on the mesoscale will be used to create highly uniform arrays of single-catalyst-particle-in-a-single-TiO2-cavity; target is a 100% reliable placement of a single <10 nm particle in a 10 nm cavity. Thus catalytic features of, for example Pt nanoparticles, can ideally interact with the photocatalytic properties of a TiO2 cavity. The cavity will be optimized for optical and electronic properties by doping and band-gap engineering; the geometry will be tuned to the range of a few nm.. This nanoscopic design yields to a radical change in the controllability of length and time-scales (reactant, charge carrier and ionic transport in the substrate) in combined photocatalytic/catalytic reactions. It is of key importance that all nanoscale assembly principles used in this work are scalable and allow to create square meters of nanoscopically ordered catalyst surfaces. We target to demonstrate the feasibility of the implementation of the nanoscale principles in a prototype macroscopic reactor.",Entirely Self-organized: Arrayed Single-Particle-in-a-Cavity Reactors for Highly Efficient and Selective Catalytic/Photocatalytic Energy Conversion and Solar Light Reaction Engineering,FP7,28 February 2019,01 March 2014,2427000.0 APOPTOPROBES,Imperial College London,health,"Magnetic resonance imaging (MRI) has become an indispensable medical diagnostic tool because of its ability to produce detailed 3D pictures of tissue in the body noninvasively. Gadolinium is used in MRI contrast agents because of its strong paramagnetic properties. However, due to its intrinsic toxicity when free in solution, it has to be bound to other biocompatible molecules to be used clinically. There are currently seven approved gadolinium contrast agents that are used for MRI studies in humans. However, these contrast agents have some drawbacks: e.g. they are not targeted to specific tissues and their sensitivity is still below what can be theoretically achieved. Therefore, there is great current interest in improving the properties of Gd-based contrast agents by attaching the metal to a variety of materials, ranging from large organic molecules to nanoparticles. Phosphatidylserine (PS) is the most abundant anionic phospholipid of the plasma membrane and, in healthy cells, is arranged largely on the inner layer. In some abnormal cells this is not the case and a considerable amount of PS is displayed on the outer membrane surface; this is known in cells undergoing apoptosis (programmed cell death) and tumour vasculature. Therefore, detection and imaging of apoptotic cells in vivo is desirable, as a clinical and research tool. Recently the host group showed that a Gd metal complex is able to bind polyphosphates and, interestingly, the probe localises selectively on apoptotic cells allowing for enhanced MRI signal in apoptotic vs. non-apoptotic cells. To follow on this previous work, we propose to develop more sensitive and selective Gd-based probes for MR imaging of apoptosis. Furthermore we propose to extend this idea towards positron emission topography (PET) by including Ga in the probes. The new probes developed, will be first fully characterised and validated in in vitro experiments to then be tested against apoptotic and non-apoptotic cell lines.",Development of novel MRI and PET probes for the detection of apoptosis,FP7,30 April 2014,01 May 2012,200371.0 APPCOPTOR,University of Trento * Università degli Studi di Trento,photonics,"Manipulation of the matter properties with radiation pressure (optical) forces is one of the high-impact topics in the multidisciplinary area of Photonics. In a photonic system often the optical and mechanical modes can effectively couple giving birth to novel fascinating phenomena described through a new discipline - Optomechanics. In this context, in a system of coupled circular resonators, of which one is mobile and the other is a fixed one, the optical forces can control the position of the mobile cavity driving it into an optically generated ultra-narrow (picometer) trapping mechanical potential. This means that the mechanical properties of an optical device, in particular its position in real space can be precisely controlled via the use of light exclusively. Therefore this system enables possible applications ranging from all-optical switching and tuning to adaptive optical filters. The objective of this proposal is to realize effectively coupled waveguide/single (and double) resonator systems monolithically integrated into a silicon chip. The project will address both optically passive and active systems. In the passive resonators we aim to demonstrate for the fist time optical trapping of an optomechanical resonator, while in the second case we will study optomechanical resonators containing silicon nanocrystals as active nonlinear material, with a final goal to demonstrate near-infrared range tunable optomechanical laser combs. Importantly, these fundamental physical phenomena will be studied in all-on-chip integrated silicon devices, thus opening door to immediate applications.",Active and Passive Photonics with Coupled Optomechanical Resonators,FP7,30 April 2013,01 May 2011,180584.0 APPLICMA,Aerospace & Advanced Composites GmbH,health,"The project aims at the development of a new type of coatings based on Complex Metallic Alloys (CMA). This is a family of ternary and quaternary alloys which exhibit unexpected properties. The CMAs 'Al61.5Cu25.3Fe12.2 B1' and 'Al59.5Cu25.3Fe12.2 B3' consist only of metals, which show not metallic- but ceramic-like behaviour. Moreover, the bulk versions of these quasicrystals have proven outstanding properties as extremely low surface energy (wetting) and highest fretting wear resistance. The CMA AlMgB14 is known to be the hardest material after diamond. However, until now these outstanding properties could not be realised as coatings. First trials to develop coating processes were not successful, but showed reasonable concepts to solve the problems. The appliCMA project will focus on the development of PVD deposited coatings based on these three well-specified compositions. Following the mentioned outstanding properties of the three CMAs, the project is driven by applications for which they offer a remarkable step forward: tools for cutting, forming, extrusion dies, moulds for injection moulding, coated cooker's oven for less sticking, fretting resistant coatings for aeroplanes, but also coatings of stamps for 'Nano-Imprint-Technology (NIL)'. The project includes 9 researchers and 8 industries (including SME) in 8 member and associated state of the EU. They will deal with the fine tailoring of coatings and the processing of surface layers by PVD processes. Measurements of the micro/nano topography, electronic structure, phase transformations, microstructure and adhesion of the CMA coatings will be realized. The project will start with 'lab samples' tested in lab facilities and will end with demonstrators tested in application related tests by end users. The project studies also fundamental mechanisms of the phase transitions in the manufacturing process of the targeted coatings, friction on these materials and simulation of friction in the forming applications.",Development of wear resistant coatings based on complex metallic alloys for functional applications,FP7,30 November 2011,01 December 2008,3341520.0 APROTHIN,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"In the future, the (information) society will drastically change. With the current progress in sub-100nm CMOS, digital signal processing (DSP), micro-electromechanical systems (MEMS), RF CMOS and nanoelectronics that rapidly merge with biotechnology, we are entering the post PC-era. We are evolving towards an intelligent environment in which we will be surrounded by smart things that communicate with each other and thereby augment our consciousness, protect our health and globally connect people and things. IMEC has anticipated on this evolution by its so called 'horizontal or heterogeneous integration” activities in which process modules are developed that provide additional functionalities to the core CMOS processes such as analog and passive devices for RF-CMOS applications, bipolar devices (BICMOS) for high frequency wireless applications, high Q passives and RF MEMS for wireless communications, embedded flash and RAM memories for data and code storage applications and devices for smart power applications. In order to support the training of European researchers in this important field of the technology, this project aims at the creation of a research-training platform for early stage researchers with focus on the interdisciplinary research, necessary to extend current technologies with extra functionality. This Early Stage Research Training (EST) project will provide an efficient way to give universities access to these technologies via a ‘sandwich Ph.D.’. In this concept, the Fellow performs his/her Ph.D. at a university in cooperation with the Host organization. In practice this means that the fellows carry out their Ph.D. partly at the university and partly at the Host organization. The research-training program will host researchers in the 5 fields of horizontal and heterogeneous integration activities: Embedded Flash and RAM memories, Mixed technology devices, Smart Power devices, RF-MEMS and Supporting activities (Reliability, Characterization)",Advanced Process Technologies for Horizontal Integration,FP6,30 September 2008,01 October 2004,475183.0 APT-STEP,"Centre for Research & Technology, Hellas * Ethniko Kentro Erevnas Kai Technologikis Anaptyxis (CERTH)",energy,"The objective of the APT-STEP project is to increase the research and innovation capacity of the Aerosol and Particle Technology Laboratory (APTL) of the Chemical Process and Energy Resources Institute (CPERI) of the Centre for Research and Technology Hellas (CERTH), a public non-profit research organization in the Region of Central Macedonia in Greece. Over the past decade, APTL has developed significant research result capital in the area of vehicle emissions control technologies; however, this technology area is maturing, and the automotive industry is turning to hybrid, electric and hydrogen fuel cell powertrain technologies in order to develop Green Mobility. APTL's research capital has been built on core competencies in aerosol science, nanomaterials synthesis and characterisation, and hierarchically structured porous ceramic reactor engineering, which are also the foundation of the novel solar reactor technologies which the laboratory has also developed for the production of renewable solar fuels. These core competencies are also very relevant for the development of hybrid, electric and hydrogen fuel cell technologies, and, therefore, the objective of the project is to help APTL adapt its research and innovation capabilities to the new opportunities in these areas. At the same time, the Region of Central Macedonia faces significant air quality problems due to pollutant emissions in the transport sector, and, therefore, the project aims to increase the visibility of APTL to regional SMEs and public and private stakeholders in order to promote greater technology and innovation transfer. The project involves four highly experienced European industries and research organisations (Honda R&D Europe GmbH, AVL List GmbH, Centro Ricerche Fiat and CERTAM) with the objective to exchange know-how and experience and to establish long term strategic partnerships. Furthermore, an important objective of the project is the recruitment of experienced researchers with know-how in powertrain testing, new powertrain technologies, and product development. The acquisition of a chassis dynamometer and a constant volume sampler to enable complete powertrain testing will complement APTL's existing engine test cell, and will enable the development of new powertrain technologies from lab scale to prototype scale.",Unlocking APTL's Scientific and Technological Research Potential in Green Mobility,FP7,30 September 2015,01 October 2012,1150921.0 AQUACAT,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"AquaCat aims to design greener chemical processes by combining the use of lipase catalysis to that of aqueous biphasic reaction media with a specific view to the synthesis of poly(lactone) nanoparticles and sugar esters for pharmaceutical, cosmetical and chemical applications. A multidisciplinary approach encompassing physical chemistry and polymer science as well as industrial biotechnology, biocatalysis and enzyme technology will be followed to cover the various relevant scales. AquaCat will tailor the lipases microenvironment, design the reaction medium making lipase function as synthetic catalyst of confined organic substrates and identify the relevant parameters for industrial scale up of these processes. AquaCat will thus circumvent major problems in the current manufacturing processes making the use of organometallic catalysts, hazardous organic solvents, high energy consumption and multi-steps for nanoparticle elaboration obsolete. Lipases will be used to catalyze the ring-opening polymerization in nano-emulsions consisting of lactone nanodroplets dispersed in aqueous or aqueous-biphasic systems. The most innovative aspect of AquaCat is to directly synthesize the core-shell poly(lactone) in one step in water. The same principle will be applied to the synthesis of important specialty chemicals like sugar esters based on renewable feedstock. A trademark of this project will thus be the possibility to transfer and merge the expert's fundamental background in colloid/polymer science, industrial biotechnology and biocatalysis from the third country into the EU giving novel insights into the basic reaction mechanisms and the influence of the emulsion properties on enzyme catalysis. Thus, AquaCat will create mutually-beneficial research co-operations and enable the application of results to other valuable substrates and could soon become a feasible strategy for the European industry to design sustainable processes for high value-added products.",Tailor made lipases for synthetic catalysis in biphasic media: From poly (lactone) applications towards novel sugar esters,FP7,31 May 2014,01 June 2012,224462.0 AQUACAT,Mahidol University,health,"AquaCat aims to design greener chemical processes by combining the use of lipase catalysis to that of aqueous biphasic reaction media with a specific view to the synthesis of poly(lactone) nanoparticles and sugar esters for pharmaceutical, cosmetical and chemical applications. A multidisciplinary approach encompassing physical chemistry and polymer science as well as industrial biotechnology, biocatalysis and enzyme technology will be followed to cover the various relevant scales. AquaCat will tailor the lipases microenvironment, design the reaction medium making lipase function as synthetic catalyst of confined organic substrates and identify the relevant parameters for industrial scale up of these processes. AquaCat will thus circumvent major problems in the current manufacturing processes making the use of organometallic catalysts, hazardous organic solvents, high energy consumption and multi-steps for nanoparticle elaboration obsolete. Lipases will be used to catalyze the ring-opening polymerization in nano-emulsions consisting of lactone nanodroplets dispersed in aqueous or aqueous-biphasic systems. The most innovative aspect of AquaCat is to directly synthesize the core-shell poly(lactone) in one step in water. The same principle will be applied to the synthesis of important specialty chemicals like sugar esters based on renewable feedstock. A trademark of this project will thus be the possibility to transfer and merge the expert's fundamental background in colloid/polymer science, industrial biotechnology and biocatalysis from the third country into the EU giving novel insights into the basic reaction mechanisms and the influence of the emulsion properties on enzyme catalysis. Thus, AquaCat will create mutually-beneficial research co-operations and enable the application of results to other valuable substrates and could soon become a feasible strategy for the European industry to design sustainable processes for high value-added products.",Tailor made lipases for synthetic catalysis in biphasic media: From poly (lactone) applications towards novel sugar esters,FP7,31 May 2015,01 June 2014,15000.0 AQUACOLL,University of Birmingham,environment,"The training programme, deals with the scientific area of colloids and particles in the natural aquatic environment,particularly freshwaters such as rivers and groundwaters. It will train 15 early stage researches in thequantitative understanding of this area of environmental chemistry and biology. In particular training will be inthe understanding of colloid influence on pollutant fate and behaviour. This area is of great importance andrelevance to the future of environmental sciences and will play a significant role in promoting future research inthe field of sustainable development and to lesser extent in areas such as Nanotechnology. The early stagefellows will also be trained (and assessed) in more generic skills (e.g. Researche Project Management, ObtainingResearch Funding etc), communicating with society and transferable skills (e.g oral and written communication,ethics, health and safety etc.). The training programme wille have a Scientist in Charge (Dr Lead), immediatelysupported by a research team (4 staff members), supervisory boards (20 further staff, with overlap) and trainingcourse leaders (approximately 20 additional staff). In addition, much support will come from the technical staff,other early stage researchers and other departments from the University. In particular, Staff development Unit,Information Services and Press Office. The Host is fully capable of meeting the training needs of the Fellows.Early stage researchers will be a mixture of PhD students registered at Birmingham University and fellows attending from other European research institutes. The early stage researchers registered for PhDs will beexpected to actively collaborate with a substantial number of other research groups, enhancing their mobility and training. A large number of collaborations with university and SME research groups have been fostered withinthis proposal. Further collaborations will also be developed during the proposal lifetime.",Colloids in the natural aquatic environment : impacts on pathogens and pollutant fate and behaviour,FP6,31 December 2008,01 September 2004,873362.44 AQUALITY,Ensatec SL,health,"Currently the identification and quantification of pollutants in water are mostly carried out manually through sampling and subsequent laboratory analysis (off-line analysis), with methodologies of work that involve some significant costs in terms of displacement to sampling points, reagents and specialized personnel dedicated to the operation, leading to time consuming and economically challenging approaches, causing the number of analyses performed to be kept at the bare minimum. The industry therefore is calling for novel, cost-effective solutions to meet these new challenges: we propose to develop an online water monitoring device for microbiological contamination analysis, that allows industries and environmental protection agencies to replace the routine activities of sampling and laboratory testing of pathogens. The new system, which will be produced in two versions, both for online and for offline measurements, will be able to real time monitor the quality of industrial process water and effluents basing on an opto-ultrasonic device and on a lipid-based diagnostic kit. The novelty of our approach is the use of engineered liposomes for detecting bacteria in water: these are nanoparticles formed by a lipid bilayer enclosing an aqueous compartment displaying features that can be different (pH, ionic strength, composition) with respect to the bulk. We will load liposomes with a chromophore and will engineer them in order to make them specifically react with one target bacteria; this is the simple operating system of the AQUALITY system, which is completed by an ultrasonic unit to concentrate bacteria and an optical unit for detecting the sample colour change following to the interaction between liposomes and bacteria.",On-line industrial water quality analysis system for rapid and accurate detection of pathogens,FP7,31 March 2014,01 December 2011,1128745.0 AQUTE,University of Ulm * Universität Ulm,information and communications technology,The overall objectives of the AQUTE project are,Atomic QUantum TEchnologies,FP7,04 June 2015,02 January 2010,0.0 ARAKNES,Sant'Anna School of Advanced Studies * Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna,health,"ARAKNES stems from the innovative idea to transfer the technologies of bi-manual laparoscopic surgery to the endoluminal surgical approach, thus further reducing the operative trauma and enhancing the therapeutic outcome of minimally invasive surgical procedures for morbid obesity and gastro-esophageal reflux. The worldwide number of bypass surgeries for obesity is predicted to rise up to 1.3 million by 2015, hence the social and industrial impact of ARAKNES is considerable. In particular, European health-systems can benefit from major reductions in costs and hospitalisation periods, the effects of which translate directly to improvements in the quality of life for many EU citizens. Through SandT excellence in micro-robotics and micro-system technologies, ARAKNES will facilitate the combination of current state-of-the-art and breakthrough innovations focusing on integrated micro-nano-bio-info devices. Specifically ARAKNESS will exploit the convergence of: - established laparoscopic techniques; - over 20 years of clinical experience with robotic and computer assisted surgery; - the maturity of micro-, nano- and bio-technologies; - the trend towards wireless, wearable and swallowable devices. This combination enables the conception of a comprehensive micro-robotic based smart operating system for advanced endoluminal surgery, which will reform established endoluminal techniques. The objectives and impact of ARAKNES are broad and ambitious. Consequently, they require a 4-year European project in the format of an IP managed by a strong and committed Consortium. The ARAKNES Consortium is a unique blend of European pioneers in all the involved disciplines (surgery, robotics, information technologies, micro- and nano-technologies) which have the vision, the commitment and the capabilities to make ARAKNES successful in terms of scientific innovation, industrial demonstrations and, ultimately, clinical application.",Array of Robots Augmenting the KiNematics of Endoluminal Surgery,FP7,30 October 2012,01 May 2008,8100000.0 ARASCOM,Thales Alenia Space France,information and communications technology,ARASCOM OBJECTIVES,"MEMS and Liquid Crystal based, Agile Reflectarray Antennas for Security and COMunication",FP7,11 February 2013,05 March 2009,0.0 ARCHAEAL MOTILITY,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The first representatives of the third domain of life, Archaea, were isolated from particularly harsh environments. Long it was thought that all archaea are 'extremophiles', but recently archaea were discovered in many temperate habitats, including the human gut, sea and soil, where they perform key roles in biochemical cycles. Archaea are the least explored domain of life and little is known about the mechanisms underlying motility and adhesion. Understanding these processes is especially timely since the widespread occurrence of archaeal species in environments including the human body is becoming more and more apparent. Archaeal motility has initially been studied using a thermophilic model organism, which has revealed that the structure responsible for swimming behavior of archaea is the 'archaellum'. The archaellum has structural homology with bacterial type IV pili, which are at the basis of the pathogenicity of many Gram negative bacteria. However, the archaellum is rotating and thereby functionally resembles the bacterial flagellum. Taking advantage of this initial expertise and knowledge on archaeal motility available in the host laboratory, this project aims to focus on the mesophilic euryarchaeal model: Haloferax volcanii. This model is very appealing to study the molecular mechanism underlying motility, because genes encoding the archaellum components are linked with those of the bacterial chemotaxis pathway in haloarchaea. In addition, this model is one of the few genetically tractable archaeal systems that allows for advanced engineering, offering the unique option to study the mechanism of rotational switching, which influences the cells 'decision' to move or stay. The proposed research is important from both fundamental and medical perspective. In addition it opens the exiting possibility to develop a stable minimal nano-motor for synthetic biology, because the archaellum represents the biological rotating filament with lowest complexity",Motiliy in the third domain of life: the haloarchaeal way to move,FP7,,,161968.0 ARCHITECHTUBE,University of Cambridge,manufacturing,"Carbon nanotubes (CNTs) form the basis of most current nanotechnology research due to their unique and extreme properties including ballistic electron transport at room temperature, structure-dependent metallic/semiconductor behaviour, electromechanical properties and extremely high Young mudulus. Several important achievements have been realised in nanotubes electronics. However, a major hindrance for the emergence of real applications is the lack of control in fabricating these nanoscale devices. This project will develop new rational design methods for CNTs based electronic nanodevices. Chemical Vapour Deposition (CVD) will be employed to grow CNTs at the desired location by placing the catalyst dots where required by focused ion beam and e-beam lithography. We will combine Ni and Co colloids chemistry and e-beam lithography to obtain small catalyst dots suitable for the growth of single wall CNTs. The recently discovered mechanism of sequential catalytic growth will be used to control the direct insertion of CNTs with spin-polarised particles during their growth. Plasma enhanced CVD will be employed for growing CNTs on thermal-sensitive substrates. Nanotubes will be oriented by the application of an electric field and by lateral growth using growth barriers. The ballistic transport of nanotubes is presently accompanied by a large contact resistance, so that the overall conductance is much lower in practice than the expected theoretical conductance. In situ growth will enable direct connecting of the nanotubes and prevent damage and pollution induced by the usual suspension/deposition process. Individual CNT structure will be characterised by in situ AFM/Raman analyses to correlate growth conditions, structural and transport properties. By using these tools, we intend to develop direct and controlled design of CNT based interconnects, field emission transistors and spin-valve devices.",Controlled carbon nanotubes assembly for nanoelectronics,FP6,30 September 2005,01 February 2005,159613.4 ARCORC,WTC Wicht Technologie Consulting,energy,"ARCORC will provide a roadmap for sub-systems based on Carbon Nanotubes to prepare for a research agenda and to build the research community. ARCORC will define major trends addressing the ICT-bio-micro/nano-technology combined field. The project will investigate technologies and major applications and products. Integration of Carbon Nanotubes as molecular building blocks in micro/nano sub-systems for applications in health care/diagnostics, sensors, energy storage systems, mass data storage systems, and display solutions will be the focus of the work. The roadmap will address research and innovation at the boundaries of nanoelectronics, biosciences and chemistry and engineering/materials sciences.","Applied Research Roadmaps for Carbon Nanotubes - Opportunities, Requirements, Challenges",FP6,31 December 2007,30 June 2006,240000.0 ARDENT,European Organization for Nuclear Research (CERN),health,"ARDENT is a multi-site ITN that will provide training for 15 ESRs in the field of advanced instrumentation for radiation dosimetry. This training initiative is founded on actions aiming to strengthen and enrich international cooperation amongst all partners involved (7 Full and 5 Associate), promoting the technological transfer of the research results to industry through the active involvement of four industrial partners (3 Full and 1 Associate). The project focuses on three main technologies: gas detectors (gas electron multipliers and tissue equivalent proportional counters), solid state detectors (Medipix and silicon microdosimeters) and track detectors (CR-39 and nanodosimeters). It addresses the development of these types of instruments for mixed-field dosimetry, microdosimetry, spectrometry, beam monitoring. The applications range from the characterization of mixed radiation fields around particle accelerators, in particular accelerators for cancer therapy with electron, proton and carbon ions, on board commercial flights and in space, to the measurement of the secondary dose to patients undergoing radiation therapy, and can equally be employed for measurement of the properties of clinical hadron beams. The overall goal of ARDENT is to train young researchers in a sector that is very important for the future of European research, at the same time fostering the development of the European private sector. Some of the institutes involved in ARDENT have a long-standing bilateral collaboration but at present there is no global collaboration amongst all partners involved in this ITN. ARDENT therefore also represents an excellent opportunity to strengthen existing links and to create a new network among all partners. A series of network-wide activities, in terms of both training and collaborative research, and a strong programme of secondments are an essential part of this ITN. Several outreach activities complete the ARDENT programme.",Advanced Radiation Dosimetry European Network Training initiative,FP7,31 January 2016,01 February 2012,3922553.0 ARGENT,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Cancer, the second most common form of death after cardiovascular disease, is a major European health concern. In 2006, 3.1 million new cases were diagnosed and 1.7 million deaths were attributed to cancer within Europe. The European Commission has a 'European Partnership for Action against Cancer' (IP/09/1380) with the aim of reducing the number of cancer cases by 15% by 2020. A key challenge is to 'Develop a more coordinated approach to cancer-related research across Europe'. Around 50% of patients receive radiotherapy as part of their cancer treatment and it is second only to surgery in its ability to cure cancer. However, radiotherapy is limited by the effects induced in the surrounding healthy tissues strongly, which very harmful for the patients. New approaches that enhance radiosensitivity within tumours have the potential to provide a major impact on the delivery of radiotherapy to patients. Two of the most promising approaches (hadron and nanoparticles-enhanced therapies) are driven by nanoscale phenomena. This proposal brings together world-leading researchers from the academic and private sectors aim at developing hadron and NP-enhanced therapies, united by the common purpose of optimising radiotherapy by understanding and exploiting nanoscale processes induced by radiation. Such an understanding will open a new era in which radiotherapy is revolutionised to provide more successful cancer treatment with subsequent economic and 'quality of life' benefits for the EU population as a whole. The main objective of this intersectoral and multidisciplinary ITN is to create a new generation of researchers and experts able to create the platform on which next-generation cancer therapy will be built. The consortium aims to train a cohort of 13 ESRs to subsequently act as leaders and ambassadors in the field.","Advanced Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies",FP7,28 February 2018,01 March 2014,3656454.0 ARRRO,WTC Wicht Technologie Consulting,information and communications technology,"RF MEMS are promising for several areas where Europe has established industrial and technology leadership from mobile telephony, automotive, to aeronautics and aerospace. The European research organisations are well placed in global competition in the field of RF MEMS and the NoE AMICOM has been created in 2004 to coordinate the research efforts. However, the European RandD is still missing a clear guideline to address the RandD needs especially with regard to RF micro-nano systems of European companies over the next 15 years. The EC has been supporting research in RF MEMS since 1998. As yet, it is though difficult for funding bodies to evaluate the return on investment. Also at industrial level, some industries are beginning to harvest the first fruits of their investment. However, these same industries are still lacking a roadmap of their future products, such as the one developed by ITRS, in order to help them set-up a clear strategy in terms of development and time to market The objective of ARRRO is to provide a strategic assessment of the current status and a vision of the future requirements for RF MEMS and RF Nanosystems technology, products and applications. From the technology point of view, ARRRO will address especially the needs for combining various technologies from Si and SiGe used so far to nanotubes for next future RF ¿NEMS¿, up to polymer for low cost antenna and integration technology. The results of this study will provide a valuable guideline for European experts and stakeholders involved in this field. Through an analysis of the European RF MEMS and nanosystems research area in the context of global competition, this study should contribute to improved integration of the European IST Research in RF MEMS. This study is complementary to the AMICOM Network of Excellence. ARRRO will also directly build on the major RF MEMS industry analysis carried out so far at the NEXUS User Supplier Club Telecom as well as by WTC.",Applied Research RoadMaps for RF micro-nano systems Opportunities,FP6,30 April 2007,30 December 2005,235000.0 ARTEMOS,Aalto University * Aalto-yliopisto,information and communications technology,"This project aims at developing architecture and technologies for implementing agile radio frequency (RF) transceiver capacities in future radio communication products. These new architecture and technologies will be able to manage multi-standard (multi-band, multi-data-rate, and multi-waveform) operation with high modularity, low-power consumption, high reliability, high integration, low costs, low PCB area, and low bill of material (BOM).",Agile RF Transceivers and Front-Ends for Future Smart Multi-Standard Communications Applications,FP7,03 January 2014,04 January 2011,0.0 ARTEN,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),health,"Enzymatic catalysis is one of the key processes for biochemical conversion in nature and of utmost importance for any form of life. The base for this kind of conversion is the enzyme itself, which is a very specialized protein targeting another molecule, peptide, or protein in a very specific way to convert it into a product with a minimum of activation energy. The latter point is very critical as it allows biochemical reactions at physiological conditions. This specialization to physiological conditions is, although beneficial for natural processes, very often a drawback for technological processes. Enzymes, being proteins, in most cases cannot resist serious deviations in temperature or pH values and degrade. This operating window of the enzymes limits their flexibility for ex vivo application in technical synthesis, food processing, etc., seriously. Inorganic nanoparticles (NPs) are considered to be a very promising alternative to enzymes as they might increase the operating window for the catalytic reaction. The research direction resembles a sort of molecular biomimetics, since inorganic phases are supposed to mimic biomaterials (enzymes) in their function. Few examples of enzyme-mimicking inorganic nanoparticles have been investigated until now, with the most prominent particles consisting of Fe3O4, CeO2, or Pt. This project aims to go far beyond the current state of the art. With protein-encapsulated inorganic nanoparticles the goal is one the one hand to gain knowledge on enzyme-analogue catalytic reactions with various inorganics and on the other hand to approach application fields of such composite inorganic enzymes by controlled modification of the protein shell they are embedded in.",Artificial Enzymes: Protein-Encapsulated Inorganic Nanoparticles,FP7,31 August 2017,01 September 2013,100000.0 ARTIC,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,health,"The ARTIC project deals with an innovative method of fluid manipulation in micro-fluidics systems, inspired by nature, namely by the mechanisms found in ciliates. A cilium can be viewed as a small hair or flexible rod (typical length 10 mm and diameter 0.1 mm) attached to the surface of micro-organisms. The cilia move back and forth collectively in a particular concerted manner, and are in this way quite effective in generating propulsion or flow (order of several mm/s). The overall objective of the ARTIC project is to explore and develop a novel micro-fluidics technology on the basis of polymeric micro-actuators inspired by the natural ciliates. The preferred method for controlled actuation of artificial cilia arrays is by using a magnetic field and incorporating magnetic nanoparticles in the polymeric cilia. The nature of the manipulation may be quite broad: transportation, mixing, sorting, deforming, or rupturing. Typical sizes of the micro-fluid channel widths and heights range from several to hundreds of micrometers. The ability to manipulate fluids in micro-channels will be essential for the development of future high-tech applications like biosensor devices, micro-channel cooling of electronics, pharmaceutical and chemical high-throughput testing and controlled drug delivery systems. The multidisciplinary character of the project is reflected by the consortium that comprises one large industrial partner, one SME, and six university groups. The industrial partners are in the fields of micro/nanotechnology and medical systems (Philips, NL), and magnetic materials (Liquids Research Ltd., UK). The university groups are world-class in the fields of polymer synthesis and nanostructuring (Freiburg, DE), micro-mechanical modelling (Groningen, NL), electromagnetic modelling and design (Bucharest, RO), biomimetics (Bath, UK), fluid flow measurement (Delft, NL), and fluid-structure interaction modelling (Eindhoven, NL).",Nature-inspired micro-fluidic manipulation using artificial cilia,FP6,30 November 2010,01 December 2006,2600000.0 ARTIFICIAL-NEURON,Curie Institute * Institut Curie,health,"The active propagation of electrochemical signals is widespread in biological organisms because of the need for efficient, rapid communication. Open questions about signaling remain because experiments with actual neurons are constrained by the neuron's complex structure and intricate feedback. The goal of this project is to develop a minimal model of the neuron in which the active propagation of electrochemical signals can be readily studied. A Giant Unilamellar Vesicle (GUV) containing voltage-gated potassium channels will serve as the 'soma' for this synthetic neuron. A long, membrane tube will be drawn out from this GUV to form an 'axon', and signal propagation along it studied with electrophysiology and fluorescence techniques. Predictions about the fundamental limits of biological signaling will be tested by measuring the speed and fidelity of the action potential as parameters including the diameter of the membrane tube, resting membrane potential and density of ion channels are varied. As intermediate goals, we will determine if membrane curvature induces protein sorting, and will also study how the shape and fluctuations of the GUV membrane are coupled to the activity of the ion channels. This project will contribute significantly to our understanding of active membranes and action potential dynamics. In the future, the skills and techniques learnt during the project may be applied to other complex processes such as signaling in networks, pacemaker activity and signal amplification cascades.",Action Potential Dynamics in a Lipid Nanotube - A Minimal Model of the Neuron,FP7,31 October 2010,01 November 2008,164777.0 ARTIST,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The ARTIST project aims at exploring alternative routes towards long distance (above 10 nm) information transport and storage at the atomic and molecular scale. ARTIST suggests new solutions for optical and electrical addressing of molecules, efficient inter-molecular communication and compatible data storage. We will implement new concepts and methods for molecular electronics based on: Addressing by: nanoscale plasmonic waveguides, electrostatics and single charge injection by weak coupling to nanocapacitors. Long distance information transport by: (i) intramolecular single electron transfer in long molecular ribbons made in situ by on-surface chemistry from precursor molecules, (ii) intermolecular propagation of proton transfer in self-assembled chains of tautomers and (iii) plasmon-mediated energy transfer. Information storage by: (i) charge trapping in atoms and molecules, (ii) conformation change and (iii) tautomerization of single molecules. The proposed devices will ensure operation time on the picosecond scale, sub-nanometer wire diameters and construction by self-assembly or on-surface chemistry. The ARTIST project is made possible by a multidisciplinary collaboration of experts in: (i) covalent and hydrogen-bonded self-assembled molecular ribbons, (ii) imaging and manipulation of molecules on thin insulating films, bulk insulators and wide band-gap semi-conductors with atomic-scale precision, (iii) nano-scale optical addressing (iv) measurements at the single molecule and electron level. (v) nanoscale fabrication using nanostencil and (vi) theory and simulation of adsorbed molecules and tunnelling A successful achievement of the project goals will open the way to a completely new nano-scale technology for information processing and storage. The ARTIST project has a clear long term potential for fabrication of reliable large arrays of molecular electronic devices.",Alternative Routes Towards Information Storage and Transport at the Atomic and Molecular Scale,FP7,31 July 2013,01 February 2010,1999248.0 ARTIVASC 3D,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"The use of bioartificial tissue for regenerative medicine offers great therapeutic potential, but also has to meet high demands with respect to the interaction of the bioartificial devices and natural tissues. Key issues for the successful use of bioartifical tissues as natural tissue replacements are their long term functional stability and biocompatible integration. Up to now, various approaches for the generation of bioartificial tissues have not succeeded due to insufficient nutrition and oxygen supply. Therefore, current tissue engineered products have only been realised for non vascularised tissues such as cartilage. ArtiVasc 3D will break new ground and overcome these challenges by providing a micro- and nano-scale based manufacturing and functionalisation technology for the generation of fully vascularised bioartificial tissue that enables entire nutrition and metabolism. The bioartificial vascularised skin engineered in ArtiVasc 3D will, for the first time, allow tissue replacement with optimum properties. ArtiVasc 3D will research and develop an innovative combination of hi-tech engineering such as micro-scale printing, nano-scale multiphoton polymerisation and electro-spinning with biological research on biochemical surface modification and complex cell culture. In a multidisciplinary approach, experts in biomaterial development, cell-matrix interaction, angiogenesis, tissue engineering, simulation, design and fabrication methods work together to generate bioartificial vascularised skin in a fully automated and standardised manufacturing approach. This bioartificial vascularised skin will be of great value in a vast array of clinical treatments, e.g. as a transplant in trauma treatment. In addition, this new bioartificial vascularised skin will be used as an innovative in vitro skin equivalent for pharmaceutical, cosmetics or chemical substance testing, which represents a promising method to reduce expensive, ethically disputed animal testing.",Artificial vascularised scaffolds for 3D-tissue-regeneration,FP7,31 October 2015,01 November 2011,7800000.0 ARTIZYMES,University of St Andrews,health,"Waste-free chemical processes are a must for a sustainable society. In nature, enzymes enable the atom economic synthesis of numerous natural products. Unfortunately, nature does not provide enzymes for the synthesis of the many pharmaceuticals, agrochemicals and fine-chemicals that are needed. To solve this problem, our interdisciplinary scientific team wants to establish a paradigm shift in catalysis research by developing 'artificial enzymes' containing transition metals that nature has not acquired for the production of important products.We propose a demanding new interdisciplinary approach for a 'de novo' design of metalloenzymes. Molecular recognition properties of proteins will be exploited by incorporation of metals such as rhodium, nickel and palladium via amino acids containing phosphino ligands. Two types of artificial enzymes are targeted, namely those with mononuclear transition metals and those with transition metal nanoclusters that are stabilised by phosphine modified peptides, enabling efficient cascade reactions. The design process is to be aided by molecular modeling and by structure determination using NMR and X-ray crystallography.By ligating small phosphino functionalised oligopeptides with proteins, we will create a new class of highly selective catalysts for reactions that nature can not perform, such as CO insertion, alkene insertion and (asymmetric) C-C coupling reactions. The catalytic performance and stability of these artizymes will be optimised by adjusting the amino acid sequence and the ligand structure. The protein part will induce the proper substrate orientation to the metal centre. Encapsulating substrates by these 'synthetic proteins' will ultimately enable clean conversion of unfunctionalised molecules by C-H activation.These catalysts will exhibit substrate specificity, i.e. they will be able to pick out a single substrate, even when it is present at low concentrations in complex mixtures.",Development of late transition metalloenzymes for highly efficient catalytic processes.,FP6,31 July 2009,01 February 2006,1800000.0 ASDAM 04,SAV - Institute of Electrical Engineering * Elektrotechnický ústav,information and communications technology,"The ASDAM Conference is being organized every second year since 1996 in Smolenice, Slovakia. During this period the Conference developed to one of the most famous and important semiconductor meetings at minimum in the Central European region. The Conference is organized alternately by the Institute of Electrical Engineering of Slovak Academy of Sciences and Faculty of Electrical Engineering and Information Technology of Slovak University of Technology in Bratislava. The Conference is devoted to the latest results of the research and development in the field of semiconductor nanodevices and microsystems. Its goal is to bring together leading experts from European Union Member States and from Associated Candidate Countries. In the Conference also the scientists from the New Independent States of the former Soviet Union take part. The proceedings of the ASDAM 96 Conference was published in re-known journal Solid-State Electronics. Proceedings of the following meeting were published by the Institute of Electrical and Electronics Engineers, Inc. - IEEE. Also the Conference ASDAM 04 will concentrate on the following topics: *Materials and nanotechnologies *Nanostructures and nanodevices *Modelling and characterization *Micro(nano)electromechanical systems. The Conference will be held from October 17th to October 21st 2004 in Smolenice Castle, Slovakia. Each Conference topic will be introduced by a leading European expert in the field. Besides invited talks there will be ten plenary and two poster sessions to illustrate the state-of-the-art and indicate future trends for every discussed topic.",fifth international conference on advanced semiconductor devices and microsystems - asdam 04,FP6,31 March 2005,01 April 2004,20000.0 ASMENA,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"More than 50% of all drug targets are membrane proteins; new research tools to screen function of membrane drug targets are therefore expected to open up new avenues for original drug development. The proposed project addresses the need of the pharmaceutical industry for new technologies for reliable and efficient screening of membrane proteins as drug targets. Most critical current aspects of membrane protein assays are (a) the lack of reliable procedures to immobilize membrane proteins on sensor surfaces in a format suitable for label-free high-throughput screening of drug candidates; (b) the need for downscaling assay formats to accelerate functional screening; and (c) the feasibility of reading out the diverse functions of membrane proteins. The partners -with highly complementary expertise and experience of working together -will develop platforms for functional membrane protein assays by integration of the most recently gained knowledge and techniques. The key concepts of the platforms include (a) exploitation of nanoporous substrates to enhance the stability of supported proteolipid membranes and their integration in a sensor chip format; (b) nanoscale surface modifications for directed self-assembly of proteolipid structures on chip; and (c) self-assembly of proteolipid membranes onto nano-sized sensor structures from proteoliposomes, and demonstration of the functionality in quantitative drug candidate screening assays suitable for commercial applications. The project is expected to make a substantial contribution to (a) improved understanding of lipid membrane and membrane protein interaction with designed nanoenvironments; (b) development of prototype products and intellectual property related to membrane protein sorting and handling; (c) new compounds for functionalization of biosensor applications; (d) cost-effective array-based concepts for nanoplasmonic and electrochemical sensing; and (e) functional assays for membrane protein drug targets.",Functional assays for membrane protein on nanostructured supports,FP7,31 August 2011,01 September 2008,3940098.0 ASSAY FOR BIOMARKERS,University College Dublin,health,"The application for the FP7-PEOPLE-2009-IEF is to support a move of a postdoctoral researcher to University College Dublin, UCD. The researcher to date has published in 16 peer reviewed journals and has a current h-index of 8. With the expert training and opportunities in place at UCD, the award of the fellowship will build upon the successful start of his academic career and deliver him to a full time academic position. This research proposal outlines a new technique capable of screening biomarkers with the capability of working directly in biological samples. The benefits of monitoring biomarkers lie in their ability to reveal signs of disease before the onset of major symptoms. The proposed technique will involve synthesizing nanoparticles to contain paramagnetic and optical properties, that will then be functionalized with aptamers/ or antibodies. These functionalized particles will capture the biomarkers directly from solution, and in conjunction with non-linear magnetophoretic separation, NLM, will allow the quick separation and detection by exploiting the particles superparamagnetic and optical properties, creating a new diagnostic technology. The experimental details will deliver a single process capable of capturing the analyte as well as performing the initial sample purification and pre-concentration stage that screens multiple biomarkers for several diseases across a wide range of molecular weights and functionalities. It will deliver benefits of being both a multiplexed technique that also offers a highly desirable tagless detection mechanism. The training that accompanies this will ensure the fellow has a broad scientific understanding, crossing several scientific fields delivering an interdisciplinary research approach. When combined with the support infrastructure in place at UCD, will deliver outstanding career enhancement prospects to the applicant, delivering a new diagnostic technique to enhance the European research portfolio.",Magnetic Nanoparticles for Multiplexed Assays for Low and High Molecular Weight Biomarkers,FP7,31 March 2012,01 June 2010,177374.0 ASSEMBLYNMR,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Supramolecular assemblies -formed by the self-assembly of hundreds of protein subunits -are part of bacterial nanomachines involved in key cellular processes. Important examples in pathogenic bacteria are pili and type 3 secretion systems (T3SS) that mediate adhesion to host cells and injection of virulence proteins. Structure determination at atomic resolution of such assemblies by standard techniques such as X-ray crystallography or solution NMR is severely limited: Intact T3SSs or pili cannot be crystallized and are also inherently insoluble. Cryo-electron microscopy techniques have recently made it possible to obtain low- and medium-resolution models, but atomic details have not been accessible at the resolution obtained in these studies, leading sometimes to inaccurate models. I propose to use solid-state NMR (ssNMR) to fill this knowledge-gap. I could recently show that ssNMR on in vitro preparations of Salmonella T3SS needles constitutes a powerful approach to study the structure of this virulence factor. Our integrated approach also included results from electron microscopy and modeling as well as in vivo assays (Loquet et al., Nature 2012). This is the foundation of this application. I propose to extend ssNMR methodology to tackle the structures of even larger or more complex homo-oligomeric assemblies with up to 200 residues per monomeric subunit. We will apply such techniques to address the currently unknown 3D structures of type I pili and cytoskeletal bactofilin filaments. Furthermore, I want to develop strategies to directly study assemblies in a native-like setting. As a first application, I will study the 3D structure of T3SS needles when they are complemented with intact T3SSs purified from Salmonella or Shigella. The ultimate goal of this proposal is to establish ssNMR as a generally applicable method that allows solving the currently unknown structures of bacterial supramolecular assemblies at atomic resolution.",3D structures of bacterial supramolecular assemblies by solid-state NMR,FP7,30 April 2019,01 May 2014,1456000.0 ASSEMIC,Vienna University of Technology * Technische Universität Wien,information and communications technology,"ASSEMIC is devoted to training and research in handling and assembly at the micro-dimension, involving advanced methods and tools and providing a multidisciplinary, complementary approach. This is to be achieved by combining the research competence of R&D centres and universities, with the application oriented view from SMEs and industrial partners. The scientific and technical complementarity required by micro-handling and assembly -an intrinsically multidisciplinary topic- will be ensured by merging the partners’ expertise in fields as design of hybrid MEMS and micro-tools, material physics and tribology, laser technology, advanced control techniques and artificial intelligence, etc. Following workpackages have been defined: 1. High resolution positioning systems, micromotors and microrobots. 2. Advanced tools and control for microhandling (visual/force feedback, haptic interfaces, etc.) 3. Microassembly tools and strategies (self-assembly, bonding, soldering…) 4. Quality management for industrial manufacturability 5. Know-how management (e-learning, technology transfer and dissemination, etc.) Special focus will be placed in training and dissemination, including workshops, open-door days, summer schools, newsletters and e-learning. Optimized and cost efficient handling and assembly of hybrid Microsystems keeps being a challenge, as assembly and packaging constitutes still a great part of MEMS manufacturing costs. ASSEMIC will raise the European technological competence and merge the research effort in this field, by multidisciplinary training both early-stage and experienced researchers in highly qualified research centres and universities, developing research and providing the practical focus of SMEs and industrial partners.",Advanced Methods and Tools for Handling and Assembly in Microtechnology,FP6,31 December 2007,01 January 2004,2755814.0 ASTHMA,University of Aberdeen,health,"Cellix Ltd., a spin-out instrumentation company from Trinity College Dublin, are experts in the area of nanotechnology and microfluidics having developed new and exciting microfluidic based technologies providing cell based assay solutions to advance basic science, medicine and drug discovery. The Academic partner is the Allergic and Asthmatic Inflammation group, School of Medicine, University of Aberdeen (UNIABDN) whose work focuses on the cells and mediators responsible for the initiation and resolution of inflammation in asthmatic and allergic disease. Asthma is now the most common chronic disease in westernised countries. It is a complex syndrome characterised by a variable degree of airway obstruction in which the fundamental abnormality is airway inflammation. One key area of ongoing work is furthering understanding of how an important pro-inflammatory effector cell in asthma, the eosinophil, selectively accumulates in the asthmatic lung. Central to this is an understanding of how eosinophils transmigrate from the blood vessels of the lung into the surrounding tissues where they exert their pro-inflammatory effects.This proposal combines proven expertise in leukocyte adhesion and transmigration (UA) with expertise in microflow adhesion of high throughput assays (Cellix). The development of the resulting platform technology will be used to identify therapeutic targets for asthma and to apply these novel technologies to other human diseases with a significant inflammatory component. By identifying those immunomodulators that facilitate/block adhesion and transmigration processes in an in vitro setting, prior to using an animal model, pharmaceutical companies would be able to remove/include such compounds from down-stream processing, thereby eliminating false leads earlier reducing the drug development cycle and cost. The new area of competence to be developed will require a multi-disciplinary effort and this is one of the key benefits of the ToK approach",Microfluidic Biochips for transendothelial migration of eosinophils for the study of asthma.,FP6,03 April 2009,04 April 2006,270898.22 ASW,Consorzio per l'Area di Ricerca Scientifica e Tecnologica di Trieste,health,"'AREA Science Weeks' is a project organized by AREA Science Park, Italy's most important science park, located in Trieste on the border with Slovenia. The specific ASW objectives are: 1. higher percentage of secondary school students that decide to take up technical and scientific university studies; 2. higher percentage of female secondary school students that decide to take up technical and scientific university studies; 3. more awareness by the public at large of the role and impact of the work of researchers in society. The project will be scheduled in four science weeks, each one dedicated to a specific topic: 1. new materials and nanotechnologies; 2. recycling and reuse of waste products; 3. biomolecular medicine; 4. astrophysics. Each science week will include a series of interactive training activities for schools as well as popular conference for the public at large involving at least one internationally-renown expert and several local researchers. A convenient number of female speakers will be present to provide reference models to future female researchers and to eradicate society's deeply-rooted preconception whereby scientific research is a typically male activity. Other local and Slovenian institutions and representatives from the business world (especially SMEs) will be involved in organizing the event, so as to encourage young researchers not to confine their career expectations to the academic world alone. The project output could be subsequently integrated in similar activities, setting the grounds for the creation of a permanent network for the promotion of the researcher's role and the dissemination of scientific culture. The project outcome could easily be transferred also to other contexts.",AREA Science Weeks,FP6,31 December 2005,01 July 2005,100000.0 ATHENIS,AMS AG,information and communications technology,"More than 20% of the value of each car already comes from embedded electronics. Keeping costs and space for additional functionality low requires further integration of electronic components such as low and high voltage devices and memory on a single System-on-Chip (SoC). SoC technologies for segments with lower reliability requirements are already available. However, there are no cost-effective technologies yet combining all of the harshest automotive reliability requirements for full SoC integration of powertrain ICs for engines, starters, alternators, etc. This barrier to powertrain IC SoC integration inhibits cost reduction and introduction of more fuel efficient cars. _x000d_",Automotive Tested High-voltage Embedded Non-volatile memory Integrated SoC,FP7,08 July 2012,01 January 2008,0.0 ATLANTIS,Research Center Fiat * Centro Recherche Fiat (CRF) SCPA,health,"ATLANTIS is motivated by the fact that suitably 3-D engineered and functionalised porous structured reactors can bring important breakthroughs not only in the already established market for automotive emission control systems, but also on the emerging biotech market of protein antibodies and bio-polymers. The S&T objectives are to produce the required knowledge base and component technologies and apply them for the manufacturing of: (i) a highly efficient, compact, multifunctional, emission control system for removal of gaseous and particulate emissions from future Diesel engines; (ii) a hyper-compact, high yield-continuous mode integrated bioreactor/separator for the bio-production of polymers and of high value recombinant protein antibodies. ATLANTIS radical innovations stem both from novel processes and novel products and include: (i) hierarchical assembly/manufacturing for new porous materials, built from 0-D (powders), 1-D (fibers), 2-D (sheets) and 3-D (foams/honeycomb monoliths) building blocks, of diverse metallic and ceramic materials; (ii) functionalization with catalysts and biocompatible surface treatments/coatings, employing novel Aerosol Technologies for 3-D tailoring of porosity and surface characteristics. The multidisciplinary and diverse application targets of ATLANTIS pulls together advanced R&D efforts in Europe, integrating different blocks of research activity. ATLANTIS will shorten the distance between R&D and market deployment in established as well as in niche ones. The critical mass achieved within the Consortium, led by a strong industrial leadership, includes specialized research centers, complemented by four large key industry players and five high tech SMEs, to ensure that R&D activities have a clear market orientation, secured exploitation of results and contribute clearly towards the objective of the Lisbon European Council in March 2000 to make the EU 'the most competitive and dynamic knowledge-based economy in the world'.",AEROSOL TECHNOLOGIES AND HIERARCHICAL ASSEMBLY/ MANUFACTURING FOR ADVANCED NANO-STRUCTURED POROUS MATERIALS,FP6,30 June 2011,01 January 2007,5144766.0 ATMNUCLE,University of Helsinki * Helsingin Yliopisto,environment,"Atmospheric aerosol particles and trace gases affect the quality of our life in many ways (e.g. health effects, changes in climate and hydrological cycle). Trace gases and atmospheric aerosols are tightly connected via physical, chemical, meteorological and biological processes occurring in the atmosphere and at the atmosphere-biosphere interface. One important phenomenon is atmospheric aerosol formation, which involves the production of nanometer-size particles by nucleation and their growth to detectable sizes. The main scientific objectives of this project are 1) to quantify the mechanisms responsible for atmospheric new particle formation and 2) to find out how important this process is for the behaviour of the global aerosol system and, ultimately, for the whole climate system. Our scientific plan is designed as a research chain that aims to advance our understanding of climate and air quality through a series of connected activities. We start from molecular simulations and laboratory measurements to understand nucleation and aerosol thermodynamic processes. We measure nanoparticles and atmospheric clusters at 15-20 sites all around the world using state of the art instrumentation and study feedbacks and interactions between climate and biosphere. With these atmospheric boundary layer studies we form a link to regional-scale processes and further to global-scale phenomena. In order to be able to simulate global climate and air quality, the most recent progress on this chain of processes must be compiled, integrated and implemented in Climate Change and Air Quality numerical models via novel parameterizations.",Atmospheric nucleation: from molecular to global scale,FP7,12 July 2015,01 January 2009,2000000.0 ATMOL,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"AtMol will establish comprehensive process flow for fabricating a molecular chip, i.e. a molecular processing unit comprising a single molecule connected to external mesoscopic electrodes with atomic scale precision and preserving the integrity of the gates down to the atomic level after the encapsulation. Logic functions will be incorporated in a single molecule gate, or performed by a single surface atomic scale circuit, via either a quantum Hamiltonian or a semi-classical design approach. AtMol will explore and demonstrate how the combination of classical and quantum information inside the same atomic scale circuit increases the computing power of the final logic circuit. Atomic scale logic gates will be constructed using atom-by-atom manipulation, on-surface chemistry, and unique UHV transfer printing technology. The AtMol research programme necessitates the state-of-the-art UHV atomic scale interconnection machines comprising, within one integrated UHV system, a surface preparation chamber, a UHV transfer printing device, an LT-UHV-STM (or a UHV-NC-AFM) for atomic scale construction, a FIM atomic scale tip apex fabrication device and a multi-probe system with its companion SEM or optical navigation microscope. Only three of these systems exist worldwide and they are each housed within the laboratories members of the AtMol consortium. These systems will be used to interconnect molecular logic gates one-by-one in a planar atomic scale multi-pad approach on the top, atomically reconstructed, surface of the wafer. For this molecular chip, the back face of the wafer will incorporate nano-to-micro-scale interconnections using nanofabricated vias which pass through the substrate to the top face. The hybrid micro-nano back interconnect approach to be developed in the AtMol project will enable the full packaging of the molecular chip preserving the surface atomic scale precision of the gates.",Atomic Scale and single Molecule Logic gate Technologies,FP7,12 July 2016,01 January 2011,6899849.0 ATMOPACS,Foundation for Research & Technology Hellas (FORTH),environment,Despite its importance for human health and climate change organic aerosol (OA) remains one of the least understood aspects of atmospheric chemistry. We propose to develop an innovative new framework for the description of OA in chemical transport and climate models that will be able to overcome the challenges posed by the chemical complexity of OA while capturing its essential features.,"Atmospheric Organic Particulate Matter, Air Quality and Climate Change Studies",FP7,12 July 2017,01 January 2011,0.0 ATOMAG,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"We propose to investigate a new frontier in Physics: the study of Magnetic systems using attosecond laser pulses. The main disciplines concerned are: Ultrafast laser sciences, Magnetism and Spin-Photonics, Relativistic Quantum Electrodynamics. Three issues of modern magnetism are addressed. 1. How fast can one modify and control the magnetization of a magnetic system ? 2. What is the role and essence of the coherent interaction between light and spins ? 3. How far spin-photonics can bring us to the real world of data acquisition and storage ? - We want first to provide solid ground experiments, unravelling the mechanisms involved in the demagnetization induced by laser pulses in a variety of magnetic materials (ferromagnetic nanostructures, aggregates and molecular magnets). We will explore the ultrafast magnetization dynamics of magnets using an attosecond laser source. - Second we want to explore how the photon field interacts with the spins. We will investigate the dynamical regime when the potential of the atoms is dressed by the Coulomb potential induced by the laser field. A strong support from the relativistic Quantum Electro-Dynamics is necessary towards that goal. - Third, even though our general approach is fundamental, we want to provide a benchmark of what is realistically possible in ultrafast spin-photonics, breaking the conventional thought that spin photonics is hard to implement at the application level. We will realize ultimate devices combining magneto-optical microscopy with the conventional magnetic recording. This new field will raise the interest of a number of competitive laboratories at the international level. Due to the overlapping disciplines the project also carries a large amount of educational impact both fundamental and applied.",From Attosecond Magnetism towards Ultrafast Spin Photonics,FP7,30 April 2015,01 May 2010,2492561.0 ATOMIC,University of York,energy,"With the dramatic advances in micro- and nano-fabrication methods, we are presented with the opportunity to control light in a way that was not possible with the materials provided to us by nature. In an artificial pattern of sub-wavelength elements, the propagation of electromagnetic energy can be defined by an equivalent spatial and spectral dispersion of effective dielectric and magnetic properties. Transformation optics (TO) is a new paradigm for the science of light, which is enabled by recent developments in our fabrication capabilities with respect to metamaterial-based devices. TO is based on the invariance of Maxwell's equations with respect to coordinate transformations, provided that the basic optical parameters of materials, dielectric permittivity ε(r) and magnetic permeability µ(r), are also transformed appropriately. This makes possible molding and controlling light on all scales, from macroscopic sizes down to the deeply sub-wavelength scale. My project aims to study the fundamentals of the emerging area of TO through the use of novel metamaterial-based devices. These photonic elements hold the promise for establishing new paradigms in integrated photonics by enabling an unprecedented control of light. We will develop both the simulation tools and the fabrication processes for creating a new-generation of planar magnifying hyperlenses and light concentrators. While the first components are fundamentally useful in order to image below the diffraction limit, the latter can be revolutionary for boosting photovoltaic cell efficiency. Following these goals, during the last part of our experimental campaign, our devices will be incorporated in two home-made set-ups; one for the evaluation of the photo-electric efficiency, and the second for the imaging of biological sample carrying sub-wavelength features. Finally, both these two experimental set-ups will be tested and characterized while the figure of merit of our devices will be evaluated.",Advanced Transformation Optical Materials for bio-Imaging and light-Concentration,FP7,14 June 2016,15 June 2013,294693.0 ATOMIC SCALE GFM,University of Southampton,manufacturing,"I will systematically exploit the quantum properties in Group-IV Materials (GFMs) at the atomic scale, by using top-down patterning processes developed for Si technologies. Among GFMs, I will examine graphene, Si, and Ge nano-structures, since these materials are technologically important. More specifically, I will use our He-Ion-Microscope (HIM) milling techniques to fabricate nano-structures beyond the resolution limit of conventional lithography. This research will: 1. Characterize Freestanding Mono-layer or thin-layer of GFMs I will fabricate the freestanding device structure by HIM. The high-resolution of HIM will enable me to fabricate the graphene nano-ribbon as narrow as 5-nm. I will also examine the atomic structures of the device by Transmission-Electron-Microscope (TEM), and compare it with electrical measurements. The similar devices can be made for ultra-thin Si films. 2. In-situ formation and characterization of Si Quantum Dot (QD) I will characterize the Si Single-Electron-Transistor with a QD by in-situ monitoring in HIM. 3. Characterization of SiGe Fins I will characterize SiGe Fin for high performance electro-absorption optical modulator applications. Impacts of the projects to EU are expected as following ways: 1. I will contribute in the interdisciplinary research areas with my strong research background in theoretical physics, nano-electronics, and Si Photonics. 2. The long-term research activities to QIP will be continued for secure communication and massive commutation, beyond the limit of the classical computations. 3. I will transfer my research experience from Japan. Especially, the industrial experience in Hitachi is helpful for running the clean room managements. 4. I will explore the innovative opportunities for sustainable electronics, in which EU communities play the important contributions towards the matured smart society. 5. I would like to establish the various collaboration within EU and internationally.",Atomic Scale Group-IV Materials for Beyond-CMOS Applications,FP7,31 August 2017,01 September 2013,100000.0 ATOMICFMR,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"Magnetoresistance, giant or tunnel, is at the heart of several ‘spintronic’ components, a new branch of electronics based on the spin of the electron with applications in information technology. Because of the never ending drive for miniaturization, spintronics is about to reach the ballistic regime of electronic transport for which spin dependent properties are still not completely understood. Further size reductions can even be achieved in constrictions of atomic sizes obtained by slowly stretching a nanostructure in a sensitively controlled manner. In these systems, static magnetotransport measurements result from the low-dimensional magnetism of a few relevant atoms. In parallel ferro-magnetic resonance (the magnetization precession induced by a radio-frequency magnetic field) has seen a renewed interest lately as it has been shown that magnetization dynamics interacts with spin currents. Its correlation with DC transport is being widely studied and it is now possible to electrically measure ferromagnetic resonance using the inverse spin Hall effect or the Anisotropic Magneto-Resistance (AMR). The latter can be scaled down to atomic sizes thus giving the possibility to open the unknown field of the dynamical magnetic properties of a single atom in a low dimensional local geometry. We have very recently demonstrated that FMR can be detected in narrow constrictions using the AMR mixed with the RF current auto induced in the magnetic circuit, leading to a measurable DC voltage. After a strong experimental effort, an original setup has been built which allows us to electrically detect the ferromagnetic resonance at 77K in samples that can be broken in real time during the measurements. This unique tool will allow us to study the resonance properties of a single atom in a low-dimensional configuration. It may even allow us to demonstrate that some metals like platinum could become magnetic in these atomic contacts.",FERROMAGNETIC RESONANCE AT THE ATOMIC SCALE,FP7,06 May 2015,06 June 2013,193594.8 ATOMICS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"Technology-computer-aided design (TCAD) is an indispensable tool for development and optimization of new generations of electronic devices in industrial environments. It was estimated in the International Technology Roadmap for Semiconductors that TCAD reduces technology development costs by 35% with a tendency to rise. However, to continue to be that useful for the 32 nm technology node and beyond, the capabilities of TCAD have to follow the paradigm shifts to processes and materials considered for such nanodevices. The objective of this project is to extend the capabilities of TCAD to the materials and doping processes used at the 32 nm node and beyond. In particular, quantitative models for the deactivation and activation mechanisms for dopants in silicon will be developed which are suited for the low ion implantation energies and low-temperature or millisecond-annealing strategies of future nanodevices. These models will be able to predict the effects of point-defect engineering and, for boron, the influence of fluorine. For strained and unstrained silicon-germanium alloys, strained silicon, and silicon-on-insulator materials, models will be developed for the evolution of extended defects and for the activation, segregation, and diffusion of dopants. Special test structures will also be used to investigate a possible diffusion anisotropy in isolated semiconductor layers. The models developed will be implemented and integrated into FLOOPS-ISE to be of immediate value to the semiconductor industry and validated with respect to their needs. To reach these ambitious goals, the consortium consists of companies active in complementary fields of competence (STM-France: device manufacturing, Mattson: equipment production, Synopsys: TCAD software, CSMA: characterization) in addition to three leading European research institutes (Fraunhofer-IISB, Univ. Surrey, CNRS-LAAS/CEMES) with extensive experience in modeling and simulation.",Advanced front-end TechnOlogy Modeling for ultimate Integrated CircuitS,FP6,31 July 2009,31 January 2006,2479736.0 ATOMICSCALECIRCUIT,Universiteit Leiden * Leiden University,information and communications technology,"My name is Christian Wagner; I am a physicist with six years of postgraduate research experience. With this proposal I apply for a one year Marie Curie fellowship in the group of Prof. Dr. Jan van Ruitenbeek at Leiden University (Netherlands).The primary aspect of the proposed project is the fabrication and investigation of a nanoscopic electronic circuit that is defined down to the atomic scale. Our project aims to create a new landmark in the field of molecular electronics. Different from state-of-the-art model systems where molecules are connected to macroscopic electrodes, we will connect a single functional molecule to monoatomic gold chains; the thinnest wires possible. The primary experimental techniques which will be employed in the realization of this project are scanning tunnelling microscopy and manipulation for the fabrication, and dI/dV transport spectroscopy, inelastic electron tunnelling spectroscopy and shot noise measurements for the investigation of the circuit. Our project is intended to create a new paradigm for the field of molecular electronics: The atom-by-atom assembly of a wire-like nanostructure on a flat surface, and the subsequent lifting of this structure into a free-standing configuration where its charge transport characteristics can be studied. The well-defined molecule-wire contacts will allow a conclusive comparison to ab-initio calculations. Apart from being an advanced model systems, the proposed structure could be the next step towards a real molecular-electronics device, e.g., if placed in a cross-bar architecture.",The next step in molecular electronics: Creation and investigation of a single-molecule circuit with atomic precision.,FP7,08 July 2016,09 January 2013,91734.9 ATOMNANO,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Techniques to interface atomic systems with quantum optical fields form a cornerstone for future technologies that aim to exploit the laws of quantum physics for enhanced performance over classical devices. For example, quantum information processing is perhaps at the forefront of such possibilities, where photons can be used to relay information over large distances, while atoms naturally are physical systems that can process and store this information. The vast majority of atom-light interfaces developed thus far have been in relatively bulky geometries, such as atomic ensembles in free space or atoms coupled to macroscopic Fabry-Perot cavities. While remarkable progress has been made, these systems remain difficult to scale up and have limited functionality compared to the potential of atomic systems coupled with state-of-the-art nano-photonic devices. ATOMNANO will be a broad theoretical effort aimed at investigating novel techniques to trap cold atoms near nano-photonic structures, developing promising applications for these systems, and advancing theoretical tools to understand the emerging physics. The constituent projects will interface compelling ideas at the interface of several fields such as quantum optics, atomic physics, nano-photonics, quantum information science, and condensed matter physics. Furthermore, ATOMNANO will involve close collaborations with leading experimental groups in these fields to rapidly identify and coordinate the most promising and fundamentally new avenues for future research.",QUANTUM INTERFACE BETWEEN ATOMIC AND NANO-PHOTONIC SYSTEMS,FP7,31 July 2016,01 August 2012,100000.0 ATOMS,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),information and communications technology,"Two decades after the giant magnetoresistance (GMR) discovery, spintronics research area has quickly led to significant progress in the field of magnetic storage. Now, a new challenge for this discipline is the implementation of new nano-radiofrequency devices liable to revolutionize telecommunication technologies. Developments of such devices require the implementation of new and highly specialized characterization tools combining a high spatial and temporal resolution in order to study the local dynamical properties of nanoscopic magnetic objects relevant for this issue.",Advanced Tools to Observe Magnetic and dynamical properties of Skyrmions and vortices down to the atomic scale,FP7,03 July 2018,04 January 2014,0.0 ATTOCALMAT,Autonomous University of Barcelona * Universitat Autònoma de Barcelona,photonics,"Nanoscale phenomena where the surface/interfaces or the small dimensions play a predominant role in the physical properties have become increasingly important in the last decade. Many characterization techniques have been adapted to face new challenges and understand new phenomena and calorimetry is no exception. ATTOCALMAT project pursues the development of a new nanocalorimetric technique the 'microsecond-pulsed steady-state method' that will combine the signal enhancing of the fast scanning and the advanced signal averaging of steady-state techniques. Preliminary results with sensitivities of 5 pJ/Kmm have already shown an improvement by a factor of 50 compared to the best steady state techniques. With the scaling down of the Si-nanochips (sensing areas~200 nm^2), the addenda reduces to few fJ/K. The increase of surface selectivity is followed by the sensitivity with values of 0.2 aJ/K. Chips with a monocristalline Si layer below the SiNx membrane will easy the study of epitaxial materials. With the new cutting edge technique and the nanochip measurement of heat capacities of single nano-objects as function of temperature but also of external variables (like magnetic and electrical field, time…) are within reach. This thermal tool will be applied to underpinning the physical properties of materials that represent a leading edge research frontier in nanoscale science towards its end-use in potential applications as magnetic storage, spintronics or photonics. Several of the challenging and unexplored measurements proposed are: (i) Magnetocalorimetry to detect Néel's wall formation in the antiferromagnetic material of an exchange biased system on physical properties. (Co/CoO or Ni/NiO) (ii) Measurements of energy involved on the 2D-3D transition of Ge epitaxial heteroestructure on Si. (iii) Nanocalorimetric study of low dimensionality effects in the ferromagnetic transition of epitaxial EuO on Si.",Atto-calorimetric tools to explore material properties in the nanoscale,FP7,31 August 2013,01 September 2010,45000.0 ATTOCO,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,photonics,"Collective electron motion can unfold on attosecond time scales in nanoplasmonic systems, as defined by the inverse spectral bandwidth of the plasmonic resonant region. Similarly, in dielectrics or semiconductors, the laser-driven collective motion of electrons can occur on this characteristic time scale. Until now, such collective electron dynamics has not been directly observed on its natural, attosecond timescale. In ATTOCO, the attosecond, sub-cycle dynamics of strong-field driven collective electron dynamics in clusters and nanoparticles will be explored. Moreover, we will explore field-dependent processes induced by strong laser fields in nanometer sized matter, such as the metallization of dielectrics, which has been recently proposed theoretically. In order to map the collective electron motion we will apply the attosecond nanoplasmonic streaking technique, which has been proposed and developed theoretically. In this approach, the temporal resolution is achieved by limiting the emission of high energetic, direct photoelectrons to a sub-cycle time window using attosecond XUV pulses phase-locked to a driving few-cycle near-infrared field. Kinetic energy spectra of the photoelectrons recorded for different delays between the excitation field and the ionizing XUV pulse will allow extracting the spatio-temporal electron dynamics. ATTOCO offers the capability to measure field-induced material changes in real-time and to gain novel insight into collective electron dynamics. In particular, we aim to learn from ATTOCO in detail, how the collective electron motion is established, how the collective motion is driven by the strong external field and over which pathways and timescale the collective motion decays. ATTOCO provides also a major step in the development of lightwave (nano-)electronics, which may push the frontiers of electronics from multi-gigahertz to petahertz frequencies. If successfully accomplished, this development will herald the potential scalability of electron-based information technologies to lightwave frequencies, surpassing the speed of current computation and communication technology by many orders of magnitude.",Attosecond tracing of collective dynamics in clusters and nanoparticles,FP7,31 May 2018,01 June 2013,1498500.0 ATTOSECOND OPTICS,Technion Israel Institute of Technology,health,"Attosecond nonlinear optics will be harnessed for increasing the efficiency and tunability of laser-driven x-rays through high harmonics generation. The process of high harmonic generation, which converts visible laser light into laser-like x-rays, facilitates new directions in science and technology. Examples include the production of attosecond pulses of light that allows direct investigation of the motions of electrons in atoms, molecules, and materials as well as the compact generation of x-rays for nano and bio imaging. However, for most applications, the generation of usable flux is, to date, limited to relatively long wavelengths (>10 nm) in which the upconversion process is rather benign and can be fully phase matched. At the foundation of this proposal are all-optical quasi-phase matching techniques, recently pioneered by the author during his post-doc in USA, which allows the holographic creation of nonlinear structures in the high harmonic generation process. Similarly to photonic structures for visible light, the optically induced nonlinear structures can be used for manipulating and enhancing the generated x-rays. New quasi-phase matching techniques will be developed and implemented for generating harmonics at 10-1 nm with high flux. Periodic structure with periodicity that varies according to the phase matching conditions of a given harmonic order will be used for generating coherent quasi-monochromatic x-rays while stochastic structures will be exploited for generating wideband x-rays. Longitudinally chirped periodic structures will be used for generating sub 100 attosecond pulses while transversely parabolic periodic structures will be exploited for focusing the generated beam at a required distance from the nonlinear medium. The proposed research will have important impact on the generation of compact and bright coherent x-rays for applications in materials and chemical dynamics, nanotechnology, microscopy, biology, and medicine.",Harnessing attosecond nonlinear optics for controlling and enhancing high harmonic generation and producing useful coherent x-rays on a tabletop,FP7,31 August 2012,01 September 2008,100000.0 AUTO-EVO,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,health,"How can we create molecular life in the lab? That is, can we drive evolvable DNA/RNA-machines under a simple nonequilibrium setting? We will trigger basic forms of autonomous Darwinian evolution by implementing replication, mutation and selection on the molecular level in a single micro-chamber? We will explore protein-free replication schemes to tackle the Eigen-Paradox of replication and translation under archaic nonequilibrium settings. The conditions mimic thermal gradients in porous rock near hydrothermal vents on the early earth. We are in a unique position to pursue these questions due to our previous inventions of convective replication, optothermal molecule traps and light driven microfluidics. Four interconnected strategies are pursued ranging from basic replication using tRNA-like hairpins, entropic cooling or UV degradation down to protein-based DNA evolution in a trap, all with biotechnological applications. The approach is risky, however very interesting physics and biology on the way. We will: (i) Replicate DNA with continuous, convective PCR in the selection of a thermal molecule trap (ii) Replicate sequences with metastable, tRNA-like hairpins exponentially (iii) Build DNA complexes by structure-selective trapping to replicate by entropic decay (iv) Drive replication by Laser-based UV degradation Both replication and trapping are exponential processes, yielding in combination a highly nonlinear dynamics. We proceed along publishable steps and implement highly efficient modes of continuous molecular evolution. As shown in the past, we will create biotechnological applications from basic scientific questions (see our NanoTemper Startup). The starting grant will allow us to compete with Jack Szostak who very recently picked up our approach [JACS 131, 9628 (2009)].",Autonomous DNA Evolution in a Molecule Trap,FP7,31 July 2015,01 August 2010,1487827.0 AUTOSUPERCAP,University of Surrey,energy,"Supercapacitors are essential in electric vehicles for supplying power during acceleration and recovering braking energy. High power and sufficient energy density (per kilo) are required for both an effective power system but also to reduce weight. There are several issues to achieve a high performance/low weight power system that need to be addressed by various groups of scientists and engineers in an integrated framework. In this proposal, we have assembled a multidisciplinary Consortium of leading researchers, organisations, highly experienced industrialists, and highly active SMEs to tackle the problems. As a result, we are aiming at developing supercapacitors of both high power and high energy density at affordable levels by the automotive industry, and of higher sustainability than many current electrochemical storage devices. These targets will be achieved by integrating several novel stages: (a) computer simulations to optimise the power system and the design of the supercapacitor bank for different supercapacitor models, representing the different supercapacitor cells to be developed and tested in this project; (b) we shall use carbon-based electrodes to reduce the amount of rare and expensive metals; (c) we shall use electrolytes of high operating voltage to increase both power and energy density, although the problem is that they have large ions that reduce the effective surface area of porous electrodes due to low diffusivity; (d) in this case, innovative electrode structures will be developed based on combinations of high surface area/large pore activated carbon electrodes and low resistance carbon fibrous materials or carbon nanotubes; graphene will also be investigated.(e) novel methodologies will be developed to integrate the innovative electrode materials in the fabrication process for manufacturing large supercapacitors. These will be tested both at small-scale, and in realistic electric car test rig tests, and be cost and life-cycle-assessed.",DEVELOPMENT OF HIGH ENERGY/HIGH POWER DENSITY SUPERCAPACITORS FOR AUTOMOTIVE APPLICATIONS,FP7,31 July 2014,01 January 2011,3974595.0 AVCOP,Millidyne Oy,manufacturing,"The AVCOP project (added-value for metallic coated products by new sol-gel processes) proposes to enable seven small manufacturing enterprising companies to re-define the product offer in the market for metal-finishing applications. The proposal seeks to combine nano-structured sol-gel coatings with ionic liquids for the first time to seal and protect anodised aluminium, hot-dip-galvanised steel and electroplated zinc. The traditional manufacturing sectors are experiencing significant threat from cheaper, low-quality and low-cost imports from lower cost economies. In the spirit of Europe 2020, the SME’s aim to respond through the exploitation of innovative surface treatments to offer the market levels of wear-resistance, corrosion protection and aesthetic appearance that exceed the best standards available today. The SME’s aim to derive significant benefits for their manufacturing processes by reducing the energy input for the anodising process by 50%, the elimination of all toxic pre-treatments from the galvanising process and the use of nano-structured, ionic-liquid-enabled coating systems, that will be entirely solvent-free. The SME consortium is drawn from member states from the four poles of the EU compass presenting a perfect representation of the developmental span for EU member states. All of the SME’s have experienced challenges through product substitution or replacement from inferior–quality imports and aim to respond proactively by drawing the leading research performers in the field of sol-gel chemistry for corrosion and wear protection and the emerging chemistry of ionic liquids",Added-value for metallic coated products by new sol-gel process,FP7,11 June 2016,12 January 2012,1059000.0 AVERT,Airbus Operations Limited,information and communications technology,"AVERT will deliver upstream aerodynamics research that will enable breakthrough technology deployment and innovative aircraft configuration development and a step change in aircraft performance. The project will contribute to the need to improve the environmental impact of aircraft emissions and the drive to strengthen the competitiveness of European manufacturing industry The major objective of AVERT is the development and industrialisation of novel active flow control technologies for a realistic configuration to significantly reduce airframe drag and thus engine CO2 emissions. This research responds to a target set in the ACARE 2020 review for a substantial increase in aircraft cruise L/D by realising the full potential of new configurations such as the 'Pro Green' aircraft. Active flow control technology can attack the two main sources of aircraft drag (profile and vortex drag) directly, by reducing skin friction drag, and indirectly by unlocking traditional configuration constraints on aircraft design and alter the focus of many design rules. It is predicted that the combined drag reduction could be up to 10% and an equivalent reduction in emissions. The achievement of the objective will give the aircraft makers within AVERT confidence that emerging flow control technologies can be industrialised to the point of practical and beneficial application to an aircraft operating in a commercial environment. The objectives will be achieved through the evaluation of selected types of device and control system, the assessment of these technologies against two baseline aircraft configurations and the validation of the most promising technologies through large scale wind tunnel testing at appropriate flight conditions. The project consortium consists of 16 organisations from 8 different countries whose researchers have significant experience in the areas of aircraft design, flow control technology, MEMS devices and wind tunnel testing.",Aerodynamic Validation of Emission Reducing,FP6,30 June 2010,01 January 2007,3899932.0 AXIS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"The project develops an innovative x-ray source based on the emerging technology of field emitting carbon nanotubes (CNT). This kind of source has several advantages with respect to traditional sources: higher intrinsic brilliance; possibility to work in pulsed and continuous mode; higher peak power; minor power consumption; modularity of beam size; good stability and longer life time. These sources are also more compact and robust, therefore suitable to be portable. The R&D activity is based on four major blocks: i) development of the cathode made of a well aligned CNT array, capable of delivering high current electron density in continuous and pulsed mode; ii) fabrication of a CNT-based electron gun which combines the CNT cathode with electron focusing optics; iii) integration of the e-gun in x-ray sources, and fabrication of an x-ray microfocusing source with characteristics of high brilliance, continuous and pulsed operation modes, easy control of beam size and power; iv) integration of the microfocusing source in two x-ray systems devoted to specific applications: a tomographic system for biomedical applications and an advanced system for material metrology applications. The implementation of phase contrast imaging methodology with this innovative source will be studied. The project will strongly enhance the competitiveness of the SME's involved in the project. The potential exploitation goes far beyond the examples addressed in the project: X-ray sources are routinely used in medical radiography, in security, in industrial quality control, in advanced research, in environmental issues and in cultural heritage. The availability of innovative sources with improved features with respect to the standard ones will have a great impact not only on Europe competitiveness in this field but also on societal aspects such as health, security, product quality, sustainability.",Advanced X-ray source based on field emitting Carbon Nanotubes cold cathode,FP7,28 February 2011,01 September 2008,1105255.0 AXOTRANSMAP,University College London,health,"The polarisation of neurons in somatodendritic and axonal compartments allows signal propagation over long distances. Despite the important role played by electrical signals, fast axonal transport is crucial for long-range communication between the soma and distal synapses, which is carried out by vesicular transport mechanisms. Neurotrophins and their receptors are internalised at axon terminals by clathrin-mediated endocytosis and conveyed by signalling endosomes to the soma, where they activate transcriptional responses regulating neuronal homeostasis and survival. However, little is known about the identity and the dynamics of the organelles involved. The aim of my project is to build a functional and physical map of axonal retrograde carriers in specific neuronal types, which are the target of important human diseases. For this purpose, I will exploit a new developed affinity purification strategy using the binding fragment of tetanus neurotoxin (HC) conjugated to monocrystalline iron oxide nanoparticles (MIONs). At different time points after internalisation, retrograde carriers will be magnetically purified and submitted to mass-spectrometry analysis. The kinetics of endosomal maturation will be assessed using quantitative label-free SILAC protocols. These results will uncover new components of signalling endosomes and identify dysfunctions of this pathway that are at the basis of motor and sensory neuropathies.",Assembling a functional map of axonal signalling endosomes,FP7,31 October 2015,01 November 2013,221606.0 BACCARA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The present project aims at improving the performance of LiB and supercapacitors. This step requires a deep understanding of interfaces and interphases evolution within the electrode in cycling in order to control and improve their properties as addressed by the Topic ENERGY.2013.7.3.3 We propose in this project to create a network of multiprobe characterization techniques in order to investigate these interfaces and their behavior through in situ/in operando methods. The goal is to control and then optimize the negative electrode/electrolyte interface (active material morphology and functionalization, electrode formulation, electrolyte formulation) by investigating structural, chemical and morphological changes during electrochemical cyclability. As stated in the call's title 'Understanding interfaces in secondary batteries and super-capacitors through in situ methods', a deep insight in the process will be gained through a network of classical and advanced techniques of characterization including large scale instruments (synchrotron and neutron beam) to investigate the electrodes at molecular and atomic scale cross with a series of operando studies on model systems coupled with numerical simulations. The new data collected therein will lead us to propose enhancement strategies, which will be tested for performance and security, searching for 'the fundamental basis for the next innovative generation of large electrical energy storage devices' (grid-scale). Since the project aims to improve interfacial and accompanying transport behaviour, we do not propose major efforts to develop new materials and we will focus on Silicon nanopowders and graphene as active or additive materials.",Battery and superCapacitor ChARActerization and testing,FP7,30 September 2016,01 October 2013,2721093.0 BACTERIAL RESPONSE,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"Bacteria in nature exhibit remarkable capacity to sense their surroundings and rapidly adapt to diverse conditions by gaining new beneficial traits. This extraordinary feature facilitates their survival when facing extreme environments. Utilizing Bacillus subtilis as our primary model organism, we propose to study two facets of this vital bacterial attribute: communication via extracellular nanotubes, and persistence as resilient spores while maintaining the potential to revive. Exploring these fascinating aspects of bacterial physiology is likely to change our view as to how bacteria sense, respond, endure and communicate with their extracellular environment. We have recently discovered a previously uncharacterized mode of bacterial communication, mediated by tubular extensions (nanotubes) that bridge neighboring cells, providing a route for exchange of intracellular molecules. Nanotube-mediated molecular sharing may represent a key form of bacterial communication in nature, allowing for the emergence of new phenotypes and increasing survival in fluctuating environments. Here we propose to develop strategies for observing nanotube formation and molecular exchange in living bacterial cells, and to characterize the molecular composition of nanotubes. We will explore the premise that nanotubes serve as a strategy to expand the cell surface, and will determine whether nanotubes provide a conduit for phage infection and spreading. Furthermore, the formation and functionality of interspecies nanotubes will be explored. An additional mode employed by bacteria to achieve extreme robustness is the ability to reside as long lasting spores. Previously held views considered the spore to be dormant and metabolically inert. However, we have recently shown that at least one week following spore formation, during an adaptive period, the spore senses and responds to environmental cues and undergoes corresponding molecular changes, influencing subsequent emergence from quiescence.",New Concepts in Bacterial Response to their Surroundings,FP7,31 March 2019,01 April 2014,1497800.0 BACTERIOSAFE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The aim of the Bacteriosafe consortium is to construct, test and develop a unique active wound dressing, which incorporates novel colourimetric sensor and active therapeutic processes for detecting and counteracting pathogenic bacteria in wounds. The inspiration for this project is the natural nano-biological mechanism of bacterial attack on healthy cells. The outer cell walls are ruptured by an array of protein toxins, lipases and other enzymes secreted by these bacteria. We mimic this natural process by using these pathogenic factors to liberate engineered and biologically derived antibiotics/antimicrobials and indicating molecules from highly designed surface immobilized nanocapsules. This will minimize the need for frequent traumatic changes of wound dressing and will provide a simple optical indicator of bacterial infection. In addition to a significant cost reduction, the proposed dressing will minimize the time required for the analysis of bacterial infection. This is particularly critical in burn wounds where delayed detection of bacterial infection can result in patient death. The project will cover both the research into the basic mechanisms of device operation, the development of a prototype device and the process engineering which is necessary to prepare it for large scale industrial production.",Active wound dressings based on biological mimicry,FP7,30 June 2014,01 July 2010,3444200.0 BACWIRE,University of Alicante * Universidad de Alicante,energy,"The aim of the project is to develop a new paradigm for the simultaneous cogeneration of energy and bioremediation using electro-active bacteria. A new nano-structured transducer that efficiently connects to these bacteria will be developed, aiming to the production of devices with superior performance across a range of applications including microbial fuel cells, whole cell biosensors and bioreactors. Elucidation of mechanisms by which bacteria transport electrons to solid electrodes is crucial. In this way, well-defined surfaces of single crystals and multilayered gold deposits on quartz elements will be used to resolve the interfacial electrochemistry of both, bacteria and isolated bacterial surface redox molecules. The spatial distribution of cytochromes in the cell surface will be determined by AFM and those involved in the electric connection to electrodes will be studied in detail. Nanoparticle-containing molecular bridges will be designed and constructed to connect electro-active bacteria to the electrode. Afterwards, tethered bacterial biofilms will be used in the development of technological application including reactors for the simultaneous cleaning of wastewater and the generation of clean energy.",Bacterial Wiring for Energy Conversion and Remediation,FP7,30 September 2012,01 October 2009,2949999.0 BAMBI,IMEP-LAHC Laboratory,information and communications technology,"We propose a theory and a hardware implementation of probabilistic computation inspired by biochemical cell signaling. We will study probabilistic computation following three axes: algebra, biology, and hardware. In each case, we will develop a bottom-up hierarchical approach starting from the elementary components, and study how to combine them to build more complex systems. We propose Bayesian gates operating on probability distributions on binary variables as the building blocks of our probabilistic algebra. These Bayesian gates can be seen as a generalization of logical operators in Boolean algebra. We propose to interpret elementary cell signaling pathways as biological implementation of these probabilistic gates. In turn, the key features of biochemical processes give new insights for innovative probabilistic hardware implementation. We propose to associate conventional electronics and novel stochastic nano-devices to build the required hardware elements. Combining them will lead to new artificial information processing systems, which could, in the future, outperform classical computers in tasks involving a direct interaction with the physical world. For these purposes, the BAMBI project associates research in Bayesian probability theory, molecular biology, nanophysics, computer science and electronics.",Bottom-up Approaches to Machines dedicated to Bayesian Inference,FP7,12 July 2018,01 January 2014,2520176.0 BAN-CANCER,Imperial College London,health,"Successful surgical treatment of breast cancer crucially depends on accurate detection of the boundaries between malignant and healthy cells (tumor margins) and is a major determinant of patient survival. The current standard for assessment of margins is the evaluation by the surgeon in the operating room followed by histological sampling. The project 'smart BANdage for CANCER margin theranostics' (BAN-CANCER) combines diagnosis of malignancy at the single cell level over a large area with stimuli-responsive delivery of therapy in a theranostic device for intraoperative detection and eradication of malignant cells at breast tumor margins. BAN-CANCER is a multidisciplinary project that combines the potential of nanoscale materials with a novel theranostic approach. It constitutes a leap forward with respect to current and proposed diagnostics, allowing to diagnose and treat breast carcinoma margin involvement for the first time (i) intraoperatively (ii) at the single cell level (iii) over the entire surgical incision; in a (iv) simple, (v) inexpensive,(vi) biocompatible package; that can be (vii) routinely employed by surgeons without requiring (viii) added equipment or (ix) prolonged analysis. BAN-CANCER will consist of a vertical array of porous silicon nanoneedles sticking out from a flexible substrate over several square cm. The gauze will be applied over the margins of the remaining breast epithelium following tumor excision allowing the nanoneedles to penetrate within each cell. The needles will be functionalized to release a fluorescent chemotherapy drug in response of abnormal cytosolic protease activity to provide simultaneous imaging and eradication of cancer cells. When the gauze will be removed the surgeon will assess the extent of margin involvement and make an informed decision extending the excision. The intracellular release of chemotherapy will ensure the death of isolated, difficult to observe cancer cells, further preventing recurrence.",Smart Bandage for Cancer Margin Theranostics,FP7,30 June 2015,01 July 2013,209033.0 BARP+,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Four to five million people in Europe and about 80 million worldwide suffer from type 1 diabetes (insulin-dependent), characterized by a deficiency in insulin secretion resulting in hyperglycaemia responsible for debilitating long-term complications (coronary diseases, acquired blindness, chronic renal failures). Recently developed immunosuppressive protocols improved the success of human allogenic pancreatic islets transplantation. However, such transplantation has severe limitations: the number of available donors and the potential toxicity of the immunosuppressive treatments. To avoid immunosupression, islets could be encapsulated to protect them from the attack of the immune system and thus from rejection. This project intends to develop, improve and validate an efficient reliable bioartificial pancreas for human application. To achieve this ambitious goal, various disciplines are integrated in a true task force of basic and clinical researchers with leading expertise in experimental diabetes and advanced modern material technologies to develop an effective approach for the treatment of type 1 diabetes. The proposed approach takes into account the far-reaching advances in the modern nanosize technology, which are of utmost importance for the success of this challenge. To cany out the project to a successful achievement, the consortium gathers a multidisciplinary group of leading European scientists with complementary competencies, spanding from biomaterials to tissue engineering, and high-tech SMEs. This transnational approach provides convincing solutions to bypass the limitations of traditional treatments of this disease. That proposal fits perfectly within the scope of Priority Nanotechnologies and nanosciences, 3.4.1, in particular Nano-biotechnologies, 3.4.1.2. Furthermore, the proposal addressed also the 3.4.1.5, Application in areas such as health and medical systems, chemistry, energy, optics, food and environment, #",Development of a bioartificial pancreas for type I diabetes therapy,FP6,31 December 2006,01 January 2004,2495600.0 BARRIER PLUS,Pra Trading Ltd.,health,"Steel is the most used metal in construction and the costs of protecting Europe's structural steel installations and assets from corrosion is thought to be 3% of GDP (or about €375BN). However, there are two factors that will increasingly affect future protective coatings developments: VOC emissions and health/safety issues. Firstly there is a strong mandate to apply VOC emissions legislation to protective coatings (and in particular extend the Paint Products Directive to include them). Secondly REACH, together with increasing effects of chemicals on humans supported through medical literature, may prevent the use of some coating materials. Our vision for BARRIER-PLUS is to develop one component waterborne barrier coatings that are competitive in performance to two component coatings. One component waterborne coatings have a number of advantages over two component coatings and solventborne systems: low VOC emissions; low fire risk; lower insurance issues; no exposure to isocyanates, epoxy resins or amines; no waste or poor film performance arising from pot life problems. Our approach is to build upon recent research in the organic/inorganic nanocomposites field to create enhanced film barrier properties. Although this project is focused on the protection of steel, the technology developed will have application in the protection of other substrates, eg concrete, brickwork and stonework.",One component waterborne barrier coatings,FP7,31 December 2016,01 January 2014,2136651.0 BASE,Dow Benelux BV,health,"The BASE-STREP aims at advancing the science and technology of sustainable and functional materials. Specifically it targets innovative nano-coatings for plastics, metals and ceramic objects, exploiting the self- assembly capabilities of short (< 25) amino-acid sequences (=peptides) in industrially relevant applications. Self- assembly is a method of spontaneous organisation of molecules into higher order structures and defined by set boundary conditions (e.g. pH, T, etc).This addresses the need for water based coating solutions beyond plastics and explores principles of nature for supramolecuar structure formation at various surfaces. These ambitions require a work programme addressing the challenges facing peptide based nano-coatings in terms of their bio-technological engineering at a cost of < 300 Euro /kg and their functional performance validation in selected self-assembled nano-coatings. The workplan covers: 1 .Laboratory solid-phase synthesis of known peptides and their evaluation 2.Experimental biosynthetic production of two peptides at laboratory (1-3L) scale and the development of efficient scale-up protocols 3.Exploring the coating capacity of tailored peptides for various substrates and environmental conditions. 4.Biotechnical production and scaling up the production of one peptide to 100 L 5.Functionality evaluation of a specific peptide for selected multi-sectorial applications targeted by the industrial partners. 6.Either production at 1000 L scale (aiming at kg quantities), or production of a second peptide in g to hg quantities to allow larger scale performance evaluation of nano-coatings on selected substrates 7.A sustainability study to assess the environmental, economic and societal impact of these novel applications. BASE brings together a diverse, highly skilled group from large industry (Dow,P&G), SME (MARE, SupraPolix, Interchem Hellas), research institutes (A&F, CIDETEC), and academia (Ghent, Leeds, Stuttgart).",Bio-based Functional materials from Engineered Self-Assembling Peptides,FP6,31 March 2009,01 April 2005,2379181.0 BB: DICJI,Institute of Science and Technology Austria,health,"The ability of cells to invade underlies many pathological conditions such as metastasis and inflammation. Invasion requires coordination of changes in the biology of the invading cell coupled with changes in the adhesive behavior and integrity of the penetrated barrier. This proposed project aims to understand the modulation of epithelial integrity during immune cell transmigration. Recent work has shown that Drosophila hemocytes invade through an epithelial barrier during embryonic development and require the small GTPase RhoL to breach Cadherin barriers. We will identify morphological and biophysical changes in epithelial integrity during this immune cell transmigration. To assess potential changes in junctional Cadherin expression during hemocyte invasion, immunofluorescence analysis and live imaging of junctional DE-Cadherin and the Actomyosin network will be performed. This will be followed by 'Fluorescence Recovery after Photobleaching' (FRAP) studies of DE-Cadherin-GFP fusion proteins to understand whether hemocyte invasion alters DE-Cadherin stability at the junctions. These experiments will provide clear insight into whether changes in DE-Cadherin integrity precede hemocyte invasion. Cell-cell junctions are known sites of mechanotransduction and hence this project will next aim to evaluate possible changes in the mechanobiology of Adherens junctions during transmigration. A FRET based tension sensor will be cloned into Drosophila and utilized to assess if there is force generation at the Adherens junctions during transmigration. This will be followed by laser nanoablation of cell junctions to assess changes in cortical tension during hemocyte invasion. These studies will concertedly address the role of junctional changes and mechanotransduction during invasion and thus provide new insight into epithelial biology during immune cell transmigration. Our studies should have relevance for future studies of pathologies like inflammation and cancer metastasis.",Breaking barriers: Investigating the junctional and mechanobiological changes underlying the ability of Drosophila immune cells to invade an epithelium.,FP7,28 February 2015,01 March 2013,179137.0 BEADSONSTRING,Tel Aviv University,health,"Next generation sequencing (NGS) is revolutionizing all fields of biological research but it fails to extract the full range of information associated with genetic material and is lacking in its ability to resolve variations between genomes. The high degree of genome variation exhibited both on the population level as well as between genetically 'identical' cells (even in the same organ) makes genetic and epigenetic analysis on the single cell and single genome level a necessity. Chromosomes may be conceptually represented as a linear one-dimensional barcode. However, in contrast to a traditional binary barcode approach that considers only two possible bits of information (1 & 0), I will use colour and molecular structure to expand the variety of information represented in the barcode. Like colourful beads threaded on a string, where each bead represents a distinct type of observable, I will label each type of genomic information with a different chemical moiety thus expanding the repertoire of information that can be simultaneously measured. A major effort in this proposal is invested in the development of unique chemistries to enable this labelling. I specifically address three types of genomic variation: Variations in genomic layout (including DNA repeats, structural and copy number variations), variations in the patterns of chemical DNA modifications (such as methylation of cytosine bases) and variations in the chromatin composition (including nucleosome and transcription factor distributions). I will use physical extension of long DNA molecules on surfaces and in nanofluidic channels to reveal this information visually in the form of a linear, fluorescent 'barcode' that is read-out by advanced imaging techniques. Similarly, DNA molecules will be threaded through a nanopore where the sequential position of 'bulky' molecular groups attached to the DNA may be inferred from temporal modulation of an ionic current measured across the pore.",Beads on String Genomics: Experimental Toolbox for Unmasking Genetic / Epigenetic Variation in Genomic DNA and Chromatin,FP7,30 September 2018,01 October 2013,1627600.0 BEARINGS,Liebherr-Aerospace Toulouse SAS,transport,"Bleed systems decrease pressure and temperature to levels acceptable for downstream pipes and air cooling system. Bleed valves, regulating the pressure, have a strong safety issue: their failures can lead to aircraft depressurization with the immediate request to land to the closest airport. In addition to all direct consequences on passengers/crews comfort, flight delay and traffic management, failures have a strong economic impact on airliners: a diversion is estimated to 150 000 ?. In 2004, 10 diversions, consecutive to valves failure, have been reported for the AIRBUS fleet. Valve failures, resulting of ball bearings blockage, are due to fretting and false Brinelling, known to occur in quasi-static assemblies in vibratory environment. Due to the power increase of new aircraft engines and the extended service life of existing aircraft, vibration levels around engines are becoming extremely strong (about 25g). Temperatures can also reach up to 550°C. Systems surrounding engine zones are therefore submitted to new and extreme environmental constraints. Even if the tendency is to develop more electrical aircraft, most of the aircraft developed today, based on bleed systems, will still be in use in the next 20 years and their issues have to be solved. Today, bearings design and materials have reached their limit. In order to propose innovative solutions answering the new requirements, BEARINGS need to i) better understand the degradations encountered, using recent advances in contact modeling ii) propose innovative materials (bulk, smart sintered, nano materials) and adapted processes, iii) propose relevant bearings designs. In the competition with United States (and Japan for bearings suppliers), BEARING is a unique opportunity to maintain European Air Systems and Bearings suppliers leadership by offering a superior and affordable European technology, which supports an invaluable strategic advantage for European airframers and airliners.",New generation of aeronautical bearings for extreme environmental constraints,FP6,14 January 2010,15 September 2006,1999793.0 BEC-ME,University Newcastle upon Tyne,environment,"Microbial electrochemical cells (MECs) show promises for energy recovery from waste and efficient wastewater treatment. MECs are bioelectrochemical reactors in which chemical energy stored in reduced substrates is converted directly into electrical energy (or hydrogen) through immobilized microbial catalysts, usually termed electroactive biofilms (EAB). Current MEC performances are not optimal and prevent their use in large-scale applications. Slow electron transfer at the microorganisms/electrode interface and low overall electroactivity of EABs are among the key scientific bottlenecks that need to be resolved in order to increase MEC output and enable their cost-effective implementation in wastewater treatment plants (WWTP). A possible solution is the development of biocompatible advanced materials for electrodes that will enable efficient “wiring” of EAB to the electrode. This project focus on development of such electrode materials and their implementation in established MECs.",Microbial Electrochemical Cells with modified electrode based on ‘forest’ like carbon nanotube (CNTs) and CNT- conducting polymers nanocomposites,FP7,10 July 2015,11 January 2011,0.0 BECKSDIMA2003,University of Wuppertal * Bergische Universität Wuppertal,information and communications technology,""Microelectronics Technology Matches"- the complexity level of today's computers could not have been achieved without miniaturisation and integration. This has not been a drive in itself, rather, integration has boosted reliability, such that 4 million transistors integrated on a chip can function for years non-stop, whereas 4 million separate transistors could only function fora split second. This stage in microelectronics development is the "System-on-a-Chip" era. The next stage is "Solution-on-a-Chip" where the sensing, signal-conditioning, data processing and delivery functionalities are all integrated on one silicon-module. The concept stems as neces¬ sary from the fact that the sheer number of connections between sub-systems makes it impossible to build complex non-contiguous devices, as an example 150 million Pixel Detectors in MCM-D technology. Some ideas and devices simply cannot be built unless the concept of "Solution-on-a- Chip" matures reliably industrially. The "System-on-a-Chip" concept integrated components in the same, or similar technology. On the other hand the "Solution-on-a-Chip" concept will have to integrate radically different technologies on the same chip, as the sensing and delivery functionalities are often developed in technologies totally incompatible with those of the signal-conditioning and data processing sub-systems. Mana¬ ging this aspect is key to the "Solution-on-a-Chip" concept, hence the interest for "Microelectronics Technology Ma tches ". Another marked difference between the "Solution-on-a-Chip" revolution (today) and the "System-on-a-Chip" revolution (1980-2000) is that the current concept addresses less so the world IT-microelectronics, but more the diverse worlds of bio/chemistry, medicine, and intelligent- environment - i.e. integrating MCM-D connectivity with sensing capabilities of porous silico",MEMS/Porous-Silicon to MCM-D Technology Matching,FP6,31 January 2006,01 February 2004,213522.0 BELERA,Belarusian State University of Informatics and Radioelectronics * Belarussky Gosudarstvenniy Universitet Informatiki I Radioelektroniki,photonics,"The overall aim of the BELERA project is to integrate the Belarusian State University of Informatics and Radioelectronics (BSUIR) into ERA by reinforcing BSUIR's research cooperation capacities and twinning with European research and innovation organisations in the following CNT and photonics related research topics: Magnetic properties of CNT; Emission properties of CNT based cold cathodes; and Nanostructured materials for novel photonic devices. These are research topics highly relevant to the FP7 NMP and FP7 ICT. BSUIR is the leading academic institution in Belarus for research in micro- and nanoelectronics; new perspective materials; beam-technologies and technics; and radio engineering devices and systems. Its researchers have published numerous research papers in international, peer-reviewed journals during the past 5 years (e.g. Journal of Applied Physics). The BELERA project will build upon BSUIR's existing strengths as a high-quality research institution via twinning and capacity building activities with the following 4 excellent European research and innovation organisations: Institut d'Électronique du Solide et des Systèmes Strasbourg, Bergische Universität Wuppertal, Universidad Politécnica de Valencia -Nanophotonics Technology Centre, and Innoveo Consulting. The capacity building activities will involve knowledge exchange, setting up joint experiments, and training development for BSUIR's researchers focused on the 3 research topics and the FP7 programme. Also, it will involve mapping and promotion of nanoelectronics and nanophotonics organisations across Belarus, and strategy development to support BSUIR and foundation of the Belarusian Nanoelectronics and Nanophotonics Technology Platform. The BELERA project will be overseen by a steering committee involving the consortium partners plus representatives of the Ministry of Education, State Committee on Science and Technology, National Academy of Sciences, and State Microelectronics Companies Integral and Planar.",Reinforcing carbon nanotubes and photonics research cooperation between the Belarusian State University of Informatics and Radioelectronics and the European Research Area,FP7,31 December 2013,01 January 2012,499696.0 BENATURAL,University of Crete * Panepistimio Kritis,health,"Protein and peptide fibers, nanotubes, and other nanoscale assemblies are considered to be candidate building blocks for a wide range of applications. These biocompatible and water soluble nanoassemblies are formed under mild conditions and are inexpensive and easy to manufacture. Their properties can be modulated by simple chemical modification in the case of peptide structures or by genetic engineering in the case of the protein assemblies. They are also able to serve as a mold for the fabrication of conductive nanowires. Furthermore, some biological nanoassemblies have thermal and chemical stability allowing their integration into fabricated devices. Protein and peptide nano-structures were also shown to be important parts of electrochemical biosensor platforms. Moreover, some peptide structures are remarkably rigid assemblies allowing advanced composite material applications. BeNatural proposes a joint interdisciplinary effort to explore the molecular arrangement and the biochemical and biophysical properties of bionanostructures using advanced biophysical techniques. It also adopts an integrated approach for the development and characterization of novel building blocks that will offer advanced structural and biological properties based on a combination of both new structural insights of the assembly process and novel non-natural amino acid analogues and modifying groups. BeNatural will also evaluate the ability of the bio-nanostructures as superior building blocks for application in biosensing and tissue engineering. The project offers a unique interdisciplinary and complex approach that will allow great progress of the research into the properties of bionanoassemblies, it will result in novel building bocks as well as practical integration strategies, and will materialize into real applications for the benefit of the society.",Bioengineered Nanomaterials for Research and Applications,FP6,31 December 2009,01 September 2006,1999970.0 BENGRAS,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"BENGRAS is a Marie Curie IIF project that focuses on multidisciplinary transfer of knowledge from a promising Australian early career researcher to KU Leuven towards the design and synthesis of novel functional nano-materials and the development of advanced analytical techniques for material analysis. The project will study bandgap engineering in graphene induced by physi- and chemi- sorption of self-assembled molecular monolayers, which is an interdisciplinary research topic centered at the interface between materials science, supramolecular chemistry, nanoscience and physics. Graphene, a material consisting of flat one-atom-thick sheets of carbon atoms has enormous potential for the use in electronic transistors because of the unique electronic properties and the reduced dimensionality. Graphene is a ‘zero-gap’ semiconductor and to unlock its electronic properties two basic requirements must be satisfied. Firstly, precise control over electronic band structure (bandgap) is needed. This can be achieved by adsorbing atoms and molecules (e.g. H, OH, K, NH3) on its surface thus generating local mid-gap states. Secondly, the means to control the degree of ordering and periodicity of modified graphene layers are to be derived. In other words, the regions where bandgap can be locally tuned have to be extended to a micron scale for practical applications. At present, this issue remains largely unexplored. This project will investigate the electronic structure of graphene the surface of which has been nano-patterned by physisorped (i.e. weak surface interactions) and covalent (i.e. strong surface interactions) molecular monolayers. Through BENGRAS the fellow will contribute extensive expertise in carbonaceous materials and spectroscopy towards controlled modification of electronic properties of graphene and, designing appropriate analytical methods for the study of low-dimensional materials using optical spectroscopy methods at the nanoscale.",Bandgap engineering of graphene by molecular self-assembly,FP7,06 March 2016,06 April 2014,177000.0 BERENICE,Catalan Health Institute * Institut Català de la Salut,health,"The BERENICE consortium is aiming at providing a new and cost-effective solution to a better treatment for Chagas chronic patients. Please see its objectives below : Main objective • Obtain a more effective, better tolerated and cheaper formulation of a drug with trypanocidal activity to cure Chagas disease Specific Objectives • Obtain results of pharmacokinetics of new formulations • Assess trypanocidal activity of new formulations in vitro and in animal model • Involve partners, research and industry in endemic countries to promote technology transfer and promote in-site solutions at cheaper cost. The foreseen results of this project would have firstly an impact on the better comprehension and control of the SUVs behavior as drug delivery nanodevices for the specific APIs to be conjugated. If this conjugation is successful, further impacts are expected dealing with technology transfer issues, such as scale-up of the corresponding SUVs preparation methodology and its implementation at industrial scale. Apart from including stong participation from endemic countries's institutions, the consortium also involves private companies, thus enabling the participation of all the key actors of the chain to confront and control better Chagas disease. The innovative approach, through the new developed nano- and microparticles based formulations will have an important impact on the safety of the medicament since the therapeutic efficacy will increase and consequently the doses needed and the incidences caused by adverse effects will be reduced.",Benznidazol and Triazol REsearch group for Nanomedicine and Innovation on Chagas diseasE,FP7,31 August 2017,01 September 2012,2998217.0 BETAIMAGE,Stichting Katholieke Universiteit * Catholic University Foundation,health,"The development of sensitive, non-invasive methods for the characterisation and quantification of beta-cell mass would greatly enhance our means for gaining understanding of the pathophysiology of diabetes and allow the development of novel therapies to prevent, halt and reverse the disease. The aim of this project is to develop and apply innovative approaches for beta-cell imaging, the emphasis being on beta-cell mass regulation (loss and neogenesis) with the perspective of entering initial clinical trials. For this purpose, our approach is to: (1) Focus on imaging technologies offering the potential to enter clinical trials during the runtime of the project. Since beta cells contribute only marginally (1-2%) to the total mass of the pancreas, a highly sensitive method for clinical imaging is required. BETA IMAGE will focus on positron emission tomography (PET) relying on chemical resolution, i.e. the specificity of a radiolabelled tracer molecule. The lead compound will be radiolabelled Exendin 4, developed in the consortium for GLP-1 receptor imaging. (2) Devise novel imaging strategies by generating labelled 'design' molecules/peptides/nanobody molecules targeting newly identified beta-cell surface proteins. These targets will be identified using a Systems Biology approach. For high-throughput tracer development, a stream-lined methodology will be established based on in vitro model systems and micro-/macroscopic in vivo real time dynamic imaging of tracer distribution by optical coherence tomography and complementary small animal PET and MRI. (3) Build on European excellence in tracer development using peptides, peptide-like and organic molecules for different imaging modalities. To achieve these ambitious goals, we have established a highly interdisciplinary and interactive project combining leading European research groups. In this way, a unique expertise is achieved regarding tracer development and imaging, beta-cells/diabetes and target definition.",Use of innovative strategies for beta-cell imaging in diabetes mellitus,FP7,31 March 2013,01 October 2008,5447136.0 BETRAPOCYS,Technische Universiteit Eindhoven * Eindhoven University of Technology,information and communications technology,"BETRAPOCYS is a knowledge transfer project aimed at conducting research and exchanging know-how on a new generation of bimodal polyethylene reactor blends with strongly enhanced processing characteristics and properties. The transfer of experience and skills will be secured through the exchange of researchers between Brazil and Europe, and a detailed program of courses, events and coaching. BETRAPOCYS will be carried out by three Brazilian and five European research organisations.",Brazil-Europe Transfer of Knowledge on Polyolefin Catalyst Systems,FP7,10 July 2019,11 January 2013,0.0 BI-NANO PT/HYDRO CNF,University of Birmingham,energy,"Proton exchange membrane fuel cells (PEMFCs) in combination with hydrogen are considered one of the best candidates to help to mitigate the climate change. However, there are still some challenges to release this technology to the market. One of the main costly issues for its commercialization is the amount of the platinum (Pt) that is used as catalyst, especially in the cathode where the oxygen reduction reaction (ORR) takes place. Even though progress has been made during the past years decreasing the Pt loading, the utilization and stability of Pt must be increased to meet the application demands by changing the current commercial carbon support (mainly Vulcan XC-72). Here it is proposed the use of a hydrophobic carbon nanofiber (CNF) layer as Pt support that combine high stability to oxidation, high specific surface area without micropores and large pore volume. The first part of the project consists of the growth of a CNF layer, which is directly grown on one side of a carbon paper substrate. The first objective of the project is the direct deposition of Pt nanoparticles on only one side of the CNF layer while avoiding a deep penetration of the Pt particles and maintaining certain hydrophobicity. The external location of the Pt particles, close to the central membrane, is crucial for a high fuel cell performance. On the other hand, certain hydrophobicity is needed to improve the evacuation of water formed in the cathode eliminating, or at least reducing, the use of PTFE. The second objective is the study of the influence of the addition of proton conductive polymers in the electrocatalytic ORR of the electrode. Finally, the last objective is the fuel cell electrochemical characterization of the electrodes by preparing membrane electrode assemblies (MEAs) by using commercial and/or in-house prepared anodes and membranes, so that the fuel cell performance can be measured and compared with a commercial MEA based on Pt/Vulcan XC-72.",'New Bi-Functional Catalyst and Meso-porous Layer for PEM Fuel Cells: Low Loading of Pt Nanoparticles on One Side of a Hydrophobic CNF Layer',FP7,,,200371.0 BIC,Sapienza University of Rome * Università degli Studi di Roma La Sapienza,health,"Cavitation is the formation of vapor cavities inside a liquid due to low pressure. Cavitation is an ubiquitous and destructive phenomenon common to most engineering applications that deal with flowing water. At the same time, the extreme conditions realized in cavitation are increasingly exploited in medicine, chemistry, and biology. What makes cavitation unpredictable is its multiscale nature: nucleation of vapor bubbles heavily depends on micro- and nanoscale details; mesoscale phenomena, as bubble collapse, determine relevant macroscopic effects, e.g., cavitation damage. In addition, macroscopic flow conditions, such as turbulence, have a major impact on it. The objective of the BIC project is to develop the lacking multiscale description of cavitation, by proposing new integrated numerical methods capable to perform quantitative predictions. The detailed and physically sound understanding of the multifaceted phenomena involved in cavitation (nucleation, bubble growth, transport, and collapse in turbulent flows) fostered by BIC project will result in new methods for designing fluid machinery, but also therapies in ultrasound medicine and chemical reactors. The BIC project builds upon the exceptionally broad experience of the PI and of his research group in numerical simulations of flows at different scales that include advanced atomistic simulations of nanoscale wetting phenomena, mesoscale models for multiphase flows, and particle-laden turbulent flows. The envisaged numerical methodologies (free-energy atomistic simulations, phase-field models, and Direct Numerical Simulation of bubble-laden flows) will be supported by targeted experimental activities, designed to validate models and characterize realistic conditions.",Cavitation across scales: following Bubbles from Inception to Collapse,FP7,31 January 2019,01 February 2014,2491200.0 BIGNSPIN,University of Zaragoza * Universidad de Zaragoza,manufacturing,"This proposal addresses new scientific challenges in spintrontronics, with the focus on the miniaturization of magnetic sensors. Bismuth crystals and graphene layers show anomalously high Fermi wave length and mean free path. This allows us the observation of electron confinement effects in the length scale of nano-lithography techniques. Both systems can be grown and processed on Si-based substrates, which paves the way for the integration with the existing semiconducting technology. Quantum transport properties are to be studied twofold: by means of intense magnetic fields in nano-patterned devices, and by means of scanning tunnelling microscopy (STM) and spectroscopy (STS) at the surface level. In Bi epitaxial films and graphene flakes, Landau quantization grants access to the topology of the Fermi surface through magnetotransport measurements. The exceptional high-mobility of Bi and graphene gives rise to giant Hall and magnetoresistance effects (> 300,000 %), strongly influenced by structural parameters. Another consequence is the large spin-difussion length, which enables the transport of spin-polarized currents through large distances. Furthermore, the spin-split surface state of Bi crystals and graphene in contact with magnetic electrodes opens up the possibility of polarizing magnetically the medium and injecting spin-polarized currents. The purpose of STM studies here is to assess the influence of structural details at the atomic level on the macroscopic magnetotransport properties of Bi and graphene. STM in combination with pulsed field experiments will be used to investigate the loss of the 2-dimensional character of the electric transport as a function of the sample thickness. Both research lines are very appealing because of the enormous potential for practical device applications and the underlying Physics behind them.",Bismuth and Graphene Nanostructures for Spintronics,FP7,03 July 2015,04 January 2010,45000.0 BIHSNAM,University of Trento * Università degli Studi di Trento,information and communications technology,"Nanomaterials such as carbon nanotubes or graphene sheets represent the future of material science, due to their potentially exceptional mechanical properties. One great drawback of all artificial materials, however, is the decrease of strength with increasing toughness, and viceversa. This problem is not encountered in many biological nanomaterials (e.g. spider silk, bone, nacre). Other biological materials display exceptional adhesion or damping properties, and can be self-cleaning or self-healing. The “secret” of biomaterials seems to lie in “hierarchy”: several levels can often be identified (2 in nacre, up to 7 in bone and dentine), from nano- to micro-scale.",Bio-inspired Hierarchical Super Nanomaterials,FP7,12 July 2018,01 January 2012,0.0 BIMACOMPULINES,Technical University of Madrid * Universidad Politécnica de Madrid,manufacturing,"This project aims to develop magnetic bistable lines for magnetic computing. Bistability is a known effect in macroscopic wires or ribbons but it has never been achieved in thin films or nanowires. The physical principle behind bistability is based on developing a helical anisotropy so the magnetization has only two possible states of minimal energy, depending on the chirality. In order to get a helical magnetic configuration across the thickness of the film, the exchange energy has to be weakened to minimize the otherwise huge energy that an in-plane domain wall would have. A way to do that is inserting layers of a weaker ferromagnet (like Gadolinium or CuCo) in the bulk of the primary ferromagnet. Bistability in nanowires would be the final stage of the project. Following the knowledge developed on films, it is expected that a similar behaviour could be observed in nanowires. They could be deposited by electrodeposition on porous membranes with a rotating magnetic field (to achieve the helical configuration) and dissolve the membrane afterwards. A bistable film could be patterned into tracks with only two single states of magnetization (easily read as 0 and 1). The speed of switching is very high and the current required for the switching could be quite low (and the same current could be used to switch an arbitrary number of tracks/wires, in this way minimizing the power consumed). There are huge obvious applications to the computing world, where Europe has done very little research to date (transmitting magnetization states between reading heads or tunnel barriers or simply transmit a large word with only one gate that would change the state of all the tracks-wires). The final approach on bistable nanowires is the next step to further miniaturization. The outcome of this research could open a large number of research lines but also a good background work for European computing companies, far behind in general from the Americans or Asians.",Development of bistable thin film lines and nanowires for magnetic computing,FP6,31 August 2007,01 September 2005,0.0 BIMORE,National Research Council * Consiglio Nazionale delle Ricerche (CNR),photonics,"The BIMORE network focuses on research and development of novel nanoscale molecular opto-electronic devices for storage and processing of information. The network will take advantage of bio-inspired approaches such as photosynthetic charge and energy transfer. The goal of the initiative is to integrate interdisciplinary expertise including organic- and biochemical synthesis, spectroscopic, structural and electrical characterization of molecules to build and characterize devices in order to shape future information technologies. The overall objective of the network is to exploit structural and unique photophysical properties of molecules, nanoscale structures and biological systems for development of efficient, nanosized electronic devices. Within the scope of the initiative are energy or charge transport investigations through single molecules or small ensembles of molecules and proteins, which can either be switched by light, be redox active, or undergo a field induced conformational change. The ground and excited states of the molecules and proteins and the involved charge transfer processes will be in depth characterized in order to gain full understanding of the investigated systems. This information is key to understanding the performance of the molecules and proteins integrated into devices and to optimize device performance. Our consortium consists of a global player with long standing European research tradition in the field of information technology, five universities and two national research institutes from eight different countries, out of which two are associated states. The network has a strong focus on interdisciplinary training in this novel field, thus closing an existing educational gap in the European Research Area. The development of complementary skills (presentation, management, technology transfer, IP protection) is implemented actively by a fixed board of experts.",Bio-inspired Molecular Optoelectronics,FP6,31 May 2011,01 October 2006,2773298.0 BINASP,Consorzio per l'Area di Ricerca Scientifica e Tecnologica di Trieste,health,"Objective of BINASP is to build-up a system of bio-nanotechnology research infrastructures and facilities in AREA Science Park within the newly formed 'TDMB-Technology District of Molecular Biomedicine' set up in the Region FVG at the end of 2004 with the endorsement of the Italian Ministry of Education, University and Research. The core and main driver of the TDMB is the 'CBM-Centre for Biomolecular Medicine', a syndicated company leaded by the Consorzio AREA which presently involves 15 shareholders, including research institutions, hi-tech manufacturing companies and financial institutes. BINASP's s goal will be achieved starting from the assets of the CBM and from the renowned European milieu of ASP, one of the largest European science & technology parks. Cornerstones of BINASP: - to promote research in nanotechnology applied to biology and medicine, and develop advanced instrumentation; - to develop collaborations with EU Nanotech R&D Centers, through the organization of scientific meetings, joint research projects, exchange programs; - to develop hi-education programmes by the promotion of PhD, start-up grants and fellowships; - to manage advanced instrumentation and laboratories for common R&D use, provide consultancy to fund raising and management for partners and others institutions; - to set-up products, to provide services and instruments useful to diagnostic and therapeutic purposes; - to exploit the market value of the relevant research results. Initial funding and locations of the project will be provided by the BINASP Partners as well as other public-private institutions; the project sustainability will be subsequently affirmed by the same institutions as well as by grants and market revenues of the intellectual property. BINASP fulfills the goals of the FP6, since it provides the basis of a European cross-cutting hi-tech platform development starting from the existing bulk of sectorial excellence competence centres.",Bio-Nano European Infrastructure in AREA Science Park,FP6,14 March 2009,15 March 2004,1912119.52 BIO LIGHT TOUCH,Agilent Technologies Austria * Agilent Technologies Österreich GmbH,health,"In this proposal we aim at developing truly novel optical scanning probe tools to allow nanometric local probing, interrogation, manipulation and dissection of biological function at the level of single molecules in their native environment: the living cell. Our objectives are two-fold: First, to pioneer the development of a novel multi-parameter scanning probe microscope able to provide for the first time simultaneous topographic, optical and biochemical recognition in one and the same instrument. Second, we will exploit the newly devised technology to unravel the organisation and dynamics of the cell surface receptor landscape at the nanometre scale in relation to cell function. As such, the proposal is fully compatible with the NEST-ADVENTURE objectives since the research is focussed on the development of an entirely new technology which, if successful, will not only open up new avenues for progress in fundamental and applied sciences but also for biotech- and high tech instrumentation- industry. Furthermore, it has a high risk character since we will attempt to enter into an uncharted territory combining areas of nano-instrumentation, nano-photonics and nanometre scale biology. In order to maximise the chances of success we have chosen for an interdisciplinary, trans-national and multi-institutional (research institutions, high education centres and industry) partnership. Thus, our working strategy will rely on the strong cooperation between the different partners, which as added value will also lead to a strengthening of cohesion in European research. In the long term we expect that both, fundamental researchers (material science, surface chemistry) as well as industrial sectors (nano-technology enterprises and the biotechnology and pharmaceutical industries) will benefit from this new technology.",Advanced near field optical tools with biochemical functional recognition at the single molecular level,FP6,28 July 2010,29 January 2007,1900000.0 BIO-CT-EXPLOIT,Vienna University of Technology * Technische Universität Wien,health,"The use of computer tomography (CT) imaging is steadily increasing in the ever growing bone implant/surgery and tissue engineering market, although commercial exploitation of CT data for structural design purposes is still based on trial-and-error approaches. This is because X-ray attenuation information is reduced to geometric grey level evaluation. However, on the academic stage, a transnational team of highly esteemed applied physicists, material scientists, engineering mechanicians, and mathematicians has recently pioneered concepts for extraction of chemical information from CT, and of its conversion, via micromechanics laws, into object –specific, inhomogeneous and anisotropic material properties. We here propose R+D activities to substantiate this cutting-edge knowledge into unparalleled, highly reliable simulation tools for structural design purposes. Most of the work load related to these R+D activities will be carried by the RTD partners, which will (upon reimbursement) transfer the simulation tools to four highly innovative SME partners covering all aspects of the bone biomaterial/surgery preplanning market, being leaders in the fields of biomaterial production, of micro and nano-CT scanner development, of image-to-geometry/mesh conversion, and of Finite Element simulation technologies. As a result of the R+D activities being carried out in close cooperation with SMEs, the latter will be, upon completion of the project, the owners of ready-to-use software packages tailored to SME-specific needs, with rapid time-to-market characteristics. The uniqueness of these products will tremendously improve the strategic market positions of the SMEs, which are expected to generate annual revenues being already multiples of the singular EC contribution -when just considering the submarkets of preplanning dental/orthopaedic surgery and bone tissue engineering research. This will trigger SME growth rates exceeding 30%, both in turnover and employment.","Innovative simulation tool for bone and bone biomaterials, based on enhanced CT-data exploitation",FP7,30 November 2011,01 December 2009,925737.0 BIO-DNP,Goethe University Frankfurt * Johann Wolfgang Goethe Universität Frankfurt am Main,health,"The scope of this study is to open up new avenues of high-resolution NMR within the fields of functional genomics and structural biology by dynamic nuclear polarization (DNP). This technique should improve the sensitivity of liquid state NMR by orders of magnitude and could extend the application field of NMR structure determination to megadalton complexes by selective enhancement of specific regions of large proteins. This method has the potential to advance the frontiers of NMR in proteomics and drug discovery. The proposal aims at the development of a cutting-edge experimental test-setup to demonstrate the use of DNP for applications in structural biology. To this end, two DNP spectrometers (HF-DNP and shuttle DNP spectrometers) will be developed. In parallel, the DNP mechanism at high magnetic fields for biological applications will be investigated and optimized methods will be developed by theoretical and numerical tools. The developed spectrometers and methods will then be used to investigate the application of the DNP technique on a broad range of biological systems. The new method will be an indispensable enhancement of NMR for the study of folding dynamics, structures of soluble and membrane proteins, metalloproteins and ribozymes as well as RNA and DNA. Additionally the exploration of the feasibility of this method for high-field NMR spectroscopy will advance further method developments in magnetic resonance as well as their application in other fields, like medical and neuronal imaging, nanostructure and semiconductor research in material sciences, analytical chemistry and pharmaceutical drug screening. The outcome of this Design Study will lead to a recommendation for the construction of a prototype DNP spectrometer and an infrastructure based on this technology, accessible for European researchers. This will give Europe a leading role in DNP research and its applications to biological structure determination.",Dynamic Nuclear Polarization for NMR in Structural Biology,FP6,31 December 2009,01 January 2006,4894788.0 BIO-LITHO,Johannes Gutenberg University of Mainz * Johannes Gutenberg-Universität Mainz,manufacturing,"The impact of biomineralization processes on lithographic and microelectronic production processes has not yet been explored. As opposed to conventional industrial manufacturing, the biological synthesis of silica occurs under mild physiological conditions of low temperatures and pressures, with clear advantages in terms of cost-effectiveness, parallel production, and impact on the environment. The integration of nature-mimic biomineralization processes with micro- and nanofabrication will be a unique route to make them usable in the medium-long term for industrial application and production. In particular, some peculiar proteins of sponges (silicateins) catalyze the reaction of silica polymerization to give ordered structures. Besides this catalytic activity, when the proteins are assembled into mesoscopic filaments, they serve as scaffolds that spatially direct the synthesis of polysiloxanes over the surface of the protein filaments. Hence, these biomolecules present the combined characteristics of: (i) chemical action (catalysis) for the formation of silica, and (ii) patterning action, by driving the silica on the surface of the filaments. We plan to exploit this unique combination within a novel technology, whose demonstrator will be the realization of patterned, aligned assembly of silica fibers, and their employment as insulating layers for prototype transistor devices. Two parallel strategies will be pursued for the production of large amounts of silicatein: (i) expression of the recombinant proteins, and (ii) development of in vitro primmorph cultures. Soft lithography techniques will be used for the controlled patterned deposition of molecules. Specific approaches will be designed and implemented, for the hierarchical assembly of silicatein fibers into functional networks. The multidisciplinary team involved in this project has the know-how in biosilicification/lithography and the intellectual property rights in enzymatic silica formation.",Biomineralization for lithography and microelectronics,FP6,30 November 2009,01 December 2006,1549381.0 BIO-MEDNANO,National University of Ireland Galway,energy,"BIO-MEDNANO STREP-project focuses on research at the frontiers of knowledge of enzymes, mediators, surfaces and immobilisation strategies aimed at improving enzymatic electron transfer reactions for application towards integrated bio-powered biosensing systems for diagnosis and healthcare. Such improvements will be provided by: screening for novel enzymes; modification of enzymes; design of novel nano-structured scaffolds for enzyme immobilization, to provide devices with improved stability and electron transfer efficiency (sensitivity and/or power output). The main scientific objective of the BIO-MEDNANO STREP -project is to increase understanding and overcome the present limitations of biofuel cell and biosensor devices based on biological electron transfer systems. The technological aim of the project, integrated bio-powered biosensing systems, will be achieved by using multidisciplinary approaches exploiting knowledge in modern biotechnology, electrochemistry, and surface and material science. Optimisation of electron transfer between the enzyme molecule and the electrode will be the challenging focus of this research, due to its generic applicability and importance. The long-term innovation of the project is to generate profound, molecular level knowledge on the electron transfer process taking place between biological molecules and electrochemically active materials and further apply this knowledge to integrated bio-powered biosensing systems. The initial targets for integrated biosensing systems will be based on development of prototype biosensors for the intermittent determination of glucose and catecholamine neurotransmitter levels in clinical samples, powered by a biofuel cell functioning on in-vivo available biofuels. The ambitious long-term aim of the development of such prototypes is to provide integrated bio-powered autonomous implantable biosensing systems for healthcare monitoring.","Integrating enzymes, mediators and nanostructures to provide bio-powered bio-electrochemical sensing systems",FP6,30 September 2009,01 July 2006,2800000.0 BIO-TRIBODIAM,University of Aveiro * Universidade de Aveiro,health,"The goal of the project is the development and application of highly adherent CVD diamond (in polycrystalline and nanocrystalline NCD- forms ) and diamond like carbon (DLC) coatings on compatible Si3N4 materials. This ceramic presents a close thermal expansion coefficient to that of diamond, reducing the thermal stresses at the interface, promoting high adhesion strength. CVD diamond/Si3N4 and DLC/Si3N4 materials have a high application potential, its use as biomaterial for surgical implants and medical devices being emphasized. The standard artificial joints are constituted by the UHMWPE/metal bio-tribological system that can be advantageously replaced by smooth DLC or NCD/Si3N4 bio-tribosystems. This is made by coating a bioactive tough ceramic that enters into the bone, with an ultra-hard biocompatible film with outstanding wear and corrosion resistance. The absence of metallic wear eradicates metallosis. Simultaneously, the reduction of UHMWPE wear will diminish the implant failure probability. Also, the production of diamond/Si3N4 medical devices for odontologic, orthopaedic and surgical uses, anticipates extended lifetime and resistance to sterilisation procedures. Si3N4 samples are diamond coated by both the microwave plasma chemical vapour deposition (MPCVD) technique for flat specimens and hot filament (HFCVD) method for complex geometries. The DLC films are grown by DC or RF magnetron sputtering. Further experiments dealing with friction and wear behaviour of CVD diamond aim the development of dry-running machine elements and metalworking tools that require no pollutant lubrication, with evident environmental benefits. As cutting tools, CVD diamond/Si3N4 inserts are tested in turning operations with real-time acquisition of cutting forces by dynamometry. The cutting of very hard materials hardmetals, like cemented carbides (WC/Co), with CVD diamond coated Si3N4 inserts, is another goal for this new system.",DLC and CVD diamond coated Si3N4 ceramics for tribological and biomedical purposes.,FP6,31 March 2008,01 April 2006,129870.0 BIO2MAN4MRI,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Nanoscience and nanotechnology are currently revolutionizing sectors such as medicine, information technologies, environmental or materials sciences, and creating new opportunities for our societies. In this context, magnetic nanoparticles (MNP) are key components to the development of novel nano- and biotechnologies. Magnetosomes are unique hybrid magnetic MNP produced by magnetotactic bacteria (MB). They are employed in applications ranging from extraction of DNA to the development of immunoassays and uses in spintronics are envisaged. However, only a very limited amount of MNP (few mg per day) can be formed by MB, and the formation principles remain to be tackled. Biomimetics, i.e. combining biological principles with chemistry, will pave the way to understand biomineralization of tailored MNP and to find out high-value high-yield synthetic routes to solve scientific and technological challenges. Specifically, we aspire at bridging the gap between different fields of science. For the first time, we will blend biological and genetic approaches with chemical and physical knowledge to understand the key parameters controlling the size, shape, composition and assembly of hybrid MNP in vivo and in vitro. We will combine nanoscience and nanotechnology to modify these properties and develop an ensemble of magnetic nanomaterials of higher values. This approach will lead to original contributions of innovative nature based on the combined skills of the partners to manufacture and characterize the biological, chemical, structural and magnetic properties of the MNP. The industrial partner will have key importance in managing and assessing the applicability of the MNP in Magnetic Resonance Imaging (MRI). Finally, our cell biologist partner will test the biocompatibility of the designed systems. In 3 years, we aim at being able to synthesize hybrid MNP with tailored magnetic and size properties by low-cost high-yield synthesis for applications in MRI.",Biomimetic and Biomineralized Magnetic Nanoparticles for Magnetic Resonance Imaging,FP7,31 August 2014,01 September 2011,1999872.0 BIOBRIDS,University of Bristol,health,"We here propose a new approach to the formation of Hierarchical Electroactive Hybrids exploiting Biological Motifs, which will provide new strategies and tools for control that will define future bottom-up 3D construction of materials in the field of functional nanomaterials for nanoelectronics. Functional electroactive oligo(aniline)s, combined with guanine hydrogen-bonding units, will be combined with single-stranded DNA block copolymers in rationally designed ways, so that information encoded in the biological materials will control spatial placement and orientation, interactions and level of functionality in three dimensions within the formed complex and hierarchical superstructures. This groundbreaking approach will utilise combinations of DNA block copolymer (BCP) self-assembly, electroactivity and encoded self-assembly, and will open unexplored avenues in the priority areas of nanotechnology, nanoelectronics and advanced materials through its interdisciplinary and multidisciplinary approach. This proposed research will rely on modern synthetic protocols of organic chemistry, chemicophysical analyses of optoelectronic properties and structure-property interplay, self-assembly in the solid state, device fabrication and testing. It is expected that the outcomes of this proposed research will impact across these disciplines, and contribute knowledge to a high priority area for both society and the research community within the EU and beyond. This fellowship and project will be an important step forward in the research career of Dr. Dasgupta, who has experience and a very strong track record in the synthesis and assembly of functional molecular architectures and supramolecular aggregation. Dr. Dasgupta will therefore be enabled, through this Marie Curie fellowship, to systematically investigate this highly relevant research area that has been left unexplored to date, and thus develop his independent scientific career fully.",Hierarchical Electroactive Hybrids exploiting Biological Motifs (BIOBRIDs),FP7,,,209033.0 BIOCARE,Karolinska Institute * Karolinska Institutet,health,"Early tumour detection and response monitoring require maximum sensitivity and specificity of the imaging methods. The programme focuses on the clinical evaluation and development of new more specific molecular tracers for the early detection of tumour cells. A large number of new and potentially more specific tracers than fluorodeoxyglucose (FDG) will be tested including amino-acid analogues, small tumour-binding peptides, aptamers, peptides binding to mutant p53 proteins and nanoparticles. The more tumour specific the tracer, the more accurately it will be possible to image the true tumour cell density, and more importantly, the true response of the tumour to therapy. There is also a need to consolidate the experience in the use of recently developed molecular tracers to assess radiotherapy and chemotherapy response in order to improve on state of the art treatments. To maximise the sensitivity and tumour image quality, a high-resolution, wide field-of-view, ultra-sensitive PET-CT camera, capable of imaging half the human body in a few minutes, will be developed. New adaptive therapy planning and biological optimisation codes and a dedicated PET-CT detector for incorporation in treatment units will be designed in close corporation between university researchers and SME's. This will allow an efficient clinical integration and high patient throughput. The associated increase in accuracy of tumour imaging and three-dimensional in vivo tumour responsiveness data will hopefully allow the clinical introduction of accurate biologically based adaptive treatment optimization methods. Some of the work- packages will try to conenct to teh Genpe, Emir and Enlight programmes but do not depend on these programmes.",Molecular Imaging for Biologically Optimised Cancer Therapy,FP6,31 December 2008,01 March 2004,6000000.0 BIOCRYSTALLOGENESIS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"The preparation of high quality crystals in order to determine three-dimensional structures of biological macromolecules is the major bottleneck of x-ray crystallography studies. This project deals with biocrystallogenesis and its goal is to provide strategies and practical methods to facilitate the preparation and the optimization of macromolecular crystals. A foreseen consequence of this approach is a faster access to structural data. The targets are aminoacyl-tRNA synthetases and transfert RNAs (tRNA) that are key actors in the translation of genetic information. These macromolecules are of immediate biological interest for the host laboratory. Indeed, their 3D structures are indispensable for a better understanding of the tRNA aminoacylation reaction. Further, the recent discovery of a link between structural alterations in such systems and human pathologies enhances this interest. The project is multidisciplinary and involves biocomputing (to create a dedicated database in order to follow and compare crystallization assays), biochemistry and molecular biology (for cloning, expression and purification of targets), physical-chemistry of crystallization (to establish phase diagrams, to crystallize the targets in gelified media, to control the growth of their crystals by temperature or pressure variation,...) and physics (to evaluate crystal quality and perfection by x-ray diffraction and topography). The project will benefit from long lasting expertise of the host laboratory and associated biology groups, and from experience in structural biology and biocomputing acquired by the proposer during his Marie Curie training period. The attribution of an ERG would encourage the first step of the proposer and apos;s career after his reintegration. It would also reinforce the development of an infrastructure for applied biocrystallogenesis at the host institute with a more general interest in the context of structural genomics prospective in the European Research Area.",Biocrystallogenesis of RNA - protein systems,FP6,30 September 2005,01 October 2004,40000.0 BIODIAGNOSTICS,Chalmers University of Technology * Chalmers Tekniska Högskola,health,"The objective of the proposed project is to develop new medical diagnostic tools based on the most sensitive detector technologies available today. A common denominator for the technologies is reading out the biological state in the magnetic domain. This will be accomplished by using both magnetic nanoparticles as substrates or tags for biological reactions and reading out the atomic nuclear spin. The latter technology is a development from the inductive readout in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). The technology used in this project is a pure magnetic field read-out system, which quite contrary to the inductive method has a sensitivity which is more or less independent of frequency and magnetic field down to very low fields. The several competing technologies will be benchmarked against each other with a model system consisting of biotin and streptavidine in order to gain a unique understanding of the differences and advantages with the different systems. To validate the concept(s), real diagnostic test will be done on in vitro detection of F1 antigen (y. pestis) Mycobacterium tuberculosis in urine samples and detection of Yersinia pestis F1 antigen in environmental samples (bio terrorism). Further to the validation, neuroimaging and instrumentation for diagnosis of neurological diseases will be investigated in vivo. (1376 characters)",Biological diagnostic tools using microsystems and supersensitive magnetic detection,FP6,31 October 2008,01 November 2005,3150000.0 BIOELECTRICSURFACE,University of Limerick,health,"According to the World Health Organisation (WHO), cardiovascular diseases cause half the deaths in the EU. It is also the main cause of years of life lost (over 30 per cent) in early death thus causing huge pressure on the labour force and family earnings. The problem is becoming more acute in Central and Eastern European countries. Due to the ageing population in the EU, osteoporosis related bone fractures have almost doubled in the last decade. It is estimated that 40 percent of women over 50 years in age will suffer from fractures due to low density bone. The European Commission considers the application of nanotechnology an important research strategy to address these problems. For this, design and control of biomaterial at the nanometer scale is set as a strategic research priority. Europe is, however, seriously under-represented in the global market for nanotherapeutics, where the United States dominates with three-quarter of the market share. While the drive for nanoscale understanding of biological interaction can be high, the application of this knowledge in marketable devices should also be prioritised. Here, we propose electrical modification of biomaterials surface to manipulate surface charge that will mediate bio/non bio interactions in vivo. We propose novel nanoscale techniques to probe this surface charge at the nanometer scale so that we have a quantitative insight to biological interaction at the biomedical device surfaces. Such an approach will help us to scale up electrical modification in cardiovascular stents, urological stents, orthopedic implants and photosterilisation devices. The research proposed here will not only provide nanoscale understanding of biological interactions on biomaterials surface but also result in novel applications and devices, which will penetrate into the market in short to medium term.",Electrically modified biomaterials surface,FP7,30 September 2011,01 October 2008,3540643.0 BIOEMERGENCES,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"With the BioEMERGENCES project, we aim at providing an experimental platform to observe in vivo emergent patterns at various scales and measure their variability between different individuals of the same species. This is a strategy towards the measurement of the individual susceptibility to genetic diseases or response to treatments.Emergent patterns arising at all levels of living organisms are influenced both by the external environment (top-down) and by the internal environment (bottom-up). As a consequence, two living beings are different even if they are two clones of the same species because the history of their coupling with their external environment is different. For these reasons, medicine evolves towards personalised protocols. To make them tangible, we have to be able to achieve the measurement at all organisation levels of the individual response to genetic defects or xenobiotics.The impossible measurement of individual differences will be tackled in a live vertebrate organism -the zebrafish- that has been largely validated as a powerful model for investigations related to human. Selected emergent phenomena arising at various scales will be recorded and reconstructed to measure the qualitative and quantitative differences between two classes of individuals. Measuring the individual response to a new class of anti-cancer drugs -the DRIL molecules- and the individual susceptibility to holoprosencephaly in a genetically deficient fish population will serve as a testbed for our experimental platform. The main result expected from BioEMERGENCES is the specification of a European platform to achieve high throughput measurement of individual differences and screening of drugs combinations such as bi or tri-therapies. Such a platform will allow responding to both the unavoidable scientific question of the construction of a synthetic description of individuals and the future requirement for new drugs in the field of personalized nano-medicine.",'In what' and 'how much' are individuals similar and different? Towards the measurement of the individual susceptibility to diseases or response to treatments.,FP6,31 May 2009,01 June 2006,1700000.0 BIOENERGY,Ruhr University Bochum * Ruhr-Universität Bochum,health,"The proposed ITN BIOENERGY deals with the understanding of experimental limits and fundamental principles for exploiting and developing electro-conducting nanoarchitectures to assemble highly efficient bioelectrocatalytic structures as a basis for efficient and stable biofuel cells. Based on that fundamental understanding, the main technological objective of BIOENERGY is to develop efficient and stable biofuel cells including potentially implantable biodevices. Individual elements like electrodes, enzymes and mediators will be developed, integrated into each other and finally assembled to bio fuel cells. ESR and ER will be work on the all tasks of this scientific chain being therefore trained in the fundamentals of bioelectrochemistry, modern experimental methods in bioelectrochemistry and applications of bioelectrochemistry. Training of the fellows will take place at the host institute, via secondments, workshops, summer schools and joint measurement campaigns. The scientific training will be completed by training of complementary skill with respect management, fund raising and scientific communication. The consortium consists of the leading scientists in bioelectrochemistry in Europe and is supported by several private partners working in the field. It is expected that BIOENERGY will improve the availability of a highly skilled workforce for European industries and research, and will be the seed of innovative long-term research and education in bioelectrochemistry.",Biofuel Cells : From fundamentals to applications of bioelectrochemistry,FP7,30 September 2017,01 October 2013,3922417.0 BIOFET,"Imperial College of Science, Technology and Medicine",health,"The growing interest in medicine in connecting different volatile organic compounds (VOCs) patterns in breath with diseases and disorders has increased the demand on breath tests devices. Nowadays, the required apparatus for breath analysis in the market are bulky and difficult to operate and handle, they need a large amount of sample and several hours are needed to obtain a result. In addition, they are expensive (ranging from 600 to 25.000euro). Therefore, the project focus on developing a breath test device which is fast, portable, extremely sensitive, with low cost and easy to miniaturize.The main challenge of the BIOFET project is the use of a tailor made biofunctional nanomaterial for gas sensing purposes in a silicon micromachined array based on field effect transistors (FET). The biofunctional material consists in a coiled-coil peptide-based assembly of gold nanoparticles and it is possible to synthesize it using different types of peptides having the possibility of designing a more selective device. The transducer device, a silicon FET microarray, can provide a lot of key benefits for sensing target gases such as low fabrication costs and mass production (standard CMOS process), low power consumption, compact size, small weights, fast response (milliseconds) and the ability to readily integrate with signal conditioning electronics and other devices.The core of the multidisciplinary research project BIOFET converges on biological recognition mechanisms, nanosciences, materials research and techniques of analysis at a common research frontier. This innovative multidisciplinary technologically relevant research is crucial in forging strong links between industry and research as outlined in the Lisbon strategy and indeed throughout FP6.",Portable and disposable biosensor microarray based on FETs with a biofunctional gate to detect VOCs in breath,FP6,30 September 2007,01 November 2005,168798.0 BIOFOS,Institute of Communications and Computer Systems,photonics,"Current methodologies for detection of food contamination based on heavy analytical tools cannot guarantee a safe and stable food supply. The reasons are the complexity, the long time-to-result (2-3 days) and the cost of these tools, which limit the number of samples that can be practically analyzed at food processing and storage sites. The need for screening tools that will be still reliable but simple, fast, low-cost, sensitive and portable for in-situ application is thus urgent. BIOFOS aims to address this need through a high-added value, reusable biosensor system based on optical interference and lab-on-a-chip (LoC) technology. To do this, BIOFOS will combine the most promising concepts from the photonic, biological, nanochemical and fluidic parts of LoC systems, aiming to overcome limitations related to sensitivity, specificity, reliability, compactness and cost issues. BIOFOS will rely on the ultra-low loss TriPleX photonic platform in order to integrate on a 4x5 mm2 chip 8 micro-ring resonators, a VCSEL and 16 Si photodiodes, and achieve a record detection limit in the change of the refractive index of 5•10-8 RIU. To support reusability and high specificity, it will rely on aptamers as biotransducers, targeting at chips for 30 uses. Advanced surface functionalization techniques will be used for the immobilization of aptamers, and new microfluidic structures will be introduced for the sample pre-treatment and the regeneration process. BIOFOS will assemble the parts in a 5x10x10 cm3 package for a sample-in-result-out, multi-analyte biosensor. The system will be validated in real settings against antibiotics, mycotoxins, pesticides and copper in milk, olive oil and nuts, aiming at detection below the legislation limits and time-to-result only 5 minutes. Based on the reusability concept, BIOFOS also aims at reducing the cost per analysis by at least a factor of 10 in the short- and 30 in the mid-term, paving the way for the commercial success of the technology.",Micro-ring resonator-based biophotonic system for food analysis,FP7,31 October 2016,01 November 2013,2750000.0 BIOFUR,Avantium Technologies BV,energy,"The BIOFUR project consists of three partners. The SME Avantium Chemicals (AVT - NL), selected as one of the Cleantech top 100 companies in 2011 and the Centre National de la Recherche Scientifique (CNRS - FR) and the University of Messina (UNIME - IT), both leaders in their respective fields. This multi-sectorial research work will contribute to breakthrough knowledge on the catalytic furanic conversion fundamentals and will be necessary for a sustainable technological development of these novel polyester materials and fuels based on renewable resources. The project consist of three workpackages: WP1: Production, Characterization, Optimisation and Environmental Impact of the Production of Polyesters; WP2: Development of Nanostructured Catalysts to improve the Performances and Sustainability of the Catalytic Conversion and Upgrading of Furanics, and; WP3: Managerial, Interdisciplinarity, Intersectoral and Dissemination aspects. The BIOFUR project shows that the proposed knowledge transfer for the three host organizations through the secondment of their own staff and the recruitment of researchers from outside the partnership is very beneficial for the host organizations by significantly increasing their research quality and overall RTD capabilities and competitiveness. The proposed dissemination and outreach activities will make sure that also to the greater European community will benefit from this project. The Coordinator of the BIOFUR project is Dr. Ed de Jong of AVT and the other lead researchers are Prof. Gabriele Centi of UNIME and Prof. Nicolas Sbirrazzuoli of CNRS.",BIOpolymers and BIOfuels from FURan based building blocks,FP7,31 December 2016,01 January 2013,920563.0 BIOFUSIN,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"This project targets the development of new enzyme-based techniques for the polymeric modification of functionalised surfaces and interfaces. Enzymes are expected to play a major role in future material preparation due to the mild conditions and remarkable enantioselectivity. In its infancy in material science, biocatalysis is an emerging field in polymer chemistry and successful integration of both disciplines would exploit the advantages of enzymatic catalysis for novel well-defined materials. Stable polymer brushes covalently bonded on a silicon surface by chemical modification can provide excellent mechanical and chemical protection, alter the electrochemical characteristics, and provide new pathways for surface functionalisation. Micropatterned polymer brushes are of crucial importance to the development of biochips and biosensor. Controlled modification of surface functionality is a key feature in the development of chemically based nanotechnology. The ability to carry out biochemical reactions catalyzed by enzymes with nanoscale precision at a surface is an important goal in the development of bottom-up nanomanufacturing. The principle aim of this project is to investigate the biocatalytic modification of functional surfaces/interfaces using the unique features of enzymes. Success in this area will be of significant interest to European industry. The ability to take this technology to the nanoscale will be novel research with high risk counterbalanced by high reward for both the biomedical, pharmaceutical and ICT industries in Europe. The approach is highly innovative and interdisciplinary and the knowledge required can only be achieved by bringing together the mutual skill-sets of the host and the applicant with the extremely high level training environment at the Technical University Eindhoven.",Biocatalytic Modification of Functionalised Surfaces and Interfaces,FP6,30 September 2008,01 December 2006,157192.04 BIOGNOSIS,Siemens AG,information and communications technology,"The main objective of this project is to develop a uniquely integrated DNA and protein detection system for medical diagnostics. Due to its ease of use and cost-effective nature, the system allows for fast as well as reliable DNA and protein testing. Aiming for point of care and doctor's office applications, e.g. early cancer recognition, this new testing system will improve public health. Moreover the project will enable a broad range of future applications in genomic risk analysis, individualized therapy and antibody detection for identification of diseases, resistances and allergies. Today bio-molecular detection is a promising technology for medical diagnosis with a high socioeconomic impact. However, due to its complexity and costs, today's systems are restricted for use at specialized laboratories, making testing expensive and time-consuming. This projects aims to overcome these problems by providing a detection system based on direct electrical read-out which can improve robustness and substantially decrease costs. This multianalyte detection system includes novel integrated sensor disposables consisting of sensor arrays, on-chip CMOS read-out circuit, the biochemical sensor interfaces as well as suitable assays. By detection of mass changes at their surface, sensors work label-free according to key-lock principles. Recent progress in DNA and protein cancer marker testing will form the basis for the development of assays for the new system. An easy-to-use read-out setup will be developed, meeting requirements of robustness and usability. A clinical validation of the system in early diagnosis of breast cancer will demonstrate the enormous impact of this key technology for public health. The project will facilitate the entry of sensor array systems into the enormous in-vitro test market. It lays the foundation for strong scientific and economic collaboration between European companies and institutes which will last long beyond the conclusion of the project.",Integrated Biosensor System for Label-Free In-Vitro DNA and Protein Diagnostics in Health-Care Applications,FP6,30 April 2009,30 July 2005,3800000.0 BIOGO-FOR-PRODUCTION,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,manufacturing,"BIO-GO-For-Production is a Large Scale Collaborative Research Project that aims to achieve a step change in the application of nanocatalysis to sustainable energy production through an integrated, coherent and holistic approach utilizing novel heterogeneous nanoparticulate catalysts in fuel syntheses. BIO-GO researches and develops advanced nanocatalysts, which are allied with advanced reactor concepts to realise modular, highly efficient, integrated processes for the production of fuels from renewable bio-oils and biogas. Principal objectives are to develop new designs, preparation routes and methods of coating nanocatalysts on innovative micro-structured reactor designs, enabling compact, integrated catalytic reactor systems that exploit fully the special properties of nanocatalysts to improve process efficiency through intensification. An important aim is to reduce the dependence on precious metals and rare earths. Catalyst development is underpinned by modelling, kinetic and in-situ studies, and is validated by extended laboratory runs of biogas and bio-oil reforming, methanol synthesis and gasoline production to benchmark performance against current commercial catalysts. The 4-year project culminates in two verification steps: (a) a 6 month continuous pilot scale catalyst production run to demonstrate scaled up manufacturing potential for fast industrialisation (b) the integration at miniplant scale of the complete integrated process to gasoline production starting from bio-oil and bio-gas feedstocks. A cost evaluation will be carried out on the catalyst production while LCA will be undertaken to analyse environmental impacts across the whole chain. BIO-GO brings together a world class multi-disciplinary team from 15 organisations to carry out the ambitious project, the results of which will have substantial strategic, economic and environmental impacts on the EU petrochemicals industry and on the increasing use of renewable feedstock for energy.",Catalytic Partial Oxidation of Bio Gas and Reforming of Pyrolysis Oil (Bio Oil) for an Autothermal Synthesis Gas Production and Conversion into Fuels,FP7,11 June 2019,12 January 2013,9037287.0 BIOINORGANIC NMR,Consorzio Interuniversitario di Risonanze Magnetiche di Metalloproteine Paramagnetiche (CIRMMP),information and communications technology,"This host institution is a Research Infrastructure supported by the European Commission for providing transnational access to biological NMR. The infrastructure is uniquely equipped with a large number of NMR spectrometers ranging from 900 MHz down to 0.01 MHz, through 800 MHz, two 700 MHz, 600 MHz, 500 MHz and 400 MHz spectrometers. It has a specialized tradition in the investigation of metalloproteins and in particular of paramagnetic metalloproteins. The aim of this application is that of moving ahead the perspective of Biological Inorganic Chemistry through the training of a new generation of doctorate students, trained at the interface between biology and inorganic chemistry through biocomputing and biospectroscopy. The availability of high technology NMR methods to study at the atomic level the structure and mobility of metalloproteins and their adducts with physiological partners and small synthetic ligands is of crucial importance in the post-genomic era. The use of the genomic databases will be exploited through bioinformatic tools for the selection of proteins for expression and for characterization in terms of structure, stability, recognition of biological partners, specificity and discovery of new folds and functions. Chemistry oriented fellows will develop aspects related to the role of metal ions in biological systems; biologically oriented fellows will go through an integrated approach from genome to proteins by using high throughput techniques, bioinformatic tools and will be exposed to spectroscopic techniques; biophysics oriented fellows will develop technological and scientific aspects through the use of high and low field NMR and flanking biophysical spectroscopies. The long term educational aim is to create scientists capable to frame specific problems in a general context, to consider multi-disciplinarity as a primary need and to consider trans-national collaboration as a requirement to develop a coherent generation of European scientists.",NMR in Inorganic Structural Biology,FP6,31 March 2008,01 April 2004,979450.0 BIOMACHINES BIOWIRES,London School of Economics and Political Science,health,"This proposal describes single-molecule studies of gene-expression mechanisms and DNA nanodevices. The completion of the human genome project has propelled the scientific community to the next frontier of biomedicine: understanding the regulation of gene expression, i.e., how, where, and when genetic information on DNA is converted into functional proteins, and how gene expression is linked to organism development and disease. Detailed studies of gene expression are usually precluded by excessive heterogeneity, large size, and transient nature of the gene-expression machinery. Such challenges are addressable by single-molecule methods which remove the ensemble averaging of bulk methods and record real-time movies of single biomachines at work. I propose to study medically important gene-expression mechanisms using single-molecule spectroscopy equipped with alternating-laser excitation (ALEX), a method that I developed as a post-doctoral researcher at the University of California, Los Angeles (UCLA). I also propose to use ALEX-based spectroscopy to study the ability of DNA-based nanodevices to transport electrons and energy, thus contributing to an emerging field of Bionanotechnology with major scientific and technological implications. All projects are high interdisciplinary, requiring expertise in physics, biophysics, chemistry, biochemistry, molecular biology, microbiology, statistics, and computer science, and thus offering an excellent opportunity for training the next generation of researchers in the fields of biotechnology and nanotechnology.",Biomolecular machines and wires,FP6,31 January 2008,01 February 2006,80000.0 BIOMAG,The Royal Institution of Great Britain,health,"Lung cancer is the most lethal cancer in the world today. There are limited options for clinicians when treating patients, with only 10-15% of lung cancer patients surviving their malignancy. Despite the introduction of new chemotherapies, lung cancer survival is unchanged from thirty years ago. New ways of treating this disease are needed. We hypothesise that modified mesenchymal stem cells (MSCs) may be used to deliver magnetic nanoparticles through their engraftment, killing both tumour epithelium and tumour vasculature, while preserving normal tissue. We propose to introduce bio-compatible tailored magnetic nanoparticles into the MSCs to enable localised cellular-level sensing and heating while retaining the full viability and functionality of the MSCs. We will examine the kinetics of MSC engraftment and compare histological samples to in vivo quantification of engraftment using contrast-enhanced small animal magnetic resonance imaging (MRI) based on sensing the MRI signal of the introduced nanoparticles. MSCs will subsequently be locally heated by applying a time-varying electromagnetic field to induce heating of the nanoparticles (a process similar in principle to that used in microwave ovens) and consequent tumour destruction. MSC delivered therapy is particularly attractive. MSCs are easy to culture, expand and genetically manipulate. They are immuno-privileged, and also home preferentially to tumour tissues allowing systemic delivery to widespread tumour and metastases. As such they offer a uniquely bio-compatible, patient-derived therapeutic solution to the life-threatening disease of lung cancer.",Magnetic Biomaterials: Magnetically Loaded Stem Cells as Diagnostic and Therapeutic Vectors for Lung Cancer,FP7,30 April 2011,01 May 2009,181350.0 BIOMAGSCAR,University College London,health,"By 2010 1.5 million stents per year will be deployed in Europe. Although outcome for patients has improved, stents still fail because of the occurrence of restenosis and thrombosis at the site of implantation. While drug eluting stents have helped to reduce the problem of restenosis, neointimal proliferation causing restenosis can still occur. Additional concerns exist regarding drug eluting stents as there appears to be a small but real increase in late and very late stent thrombosis, particularly after discontinuation of antiplatelet therapy. The novel concept we propose is use of a biodegradable magnetised stent (BMS) to deliver a novel biological therapy offering regenerative medicine solutions to the coronary artery vessel wall. Specifically we will develop the stent technology as a platform to attract autologous progenitor cells tagged in vitro with iron nanoparticles. Once deployed, the cells will be attracted to the already implanted BMS and proliferate to form a new endothelium. We will also use over-expression of the NRP1 gene in the artery wall where it will dimerise with NRP1 receptors on the deployed cells. The NRP1 gene will be transfected by adenovirus delivered from the wall of the BMS. Over time the BMS will undergo a predictable degradation to leave a wholly biological artery through regeneration of native tissues. Currently, about 12,000 European Citizens a year suffer from late in-stent thrombosis and 120,000 from restenosis. With the knowledge and technologies developed through the BIOMAGSCAR project we aim to halve this number of patients and save 66,000 people from unnecessary suffering, saving the European healthcare system €275 million p.a. in direct costs, only 10% of the total associated costs. Our consortium includes a vascular disease therapy company, a stent research and manufacturing company, four universities and a specialist in innovative technology investment, all of whom believe our technology will dramatically change this field.",Biodegradable Magnetic Stent for Coronary Artery Luminal Regeneration,FP7,31 December 2015,01 January 2012,5299478.0 BIOMAGSENS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"The proposal is a RTD project and is submitted in response to the call IST-NMP-2 Bio-sensors for Diagnosis and Healthcare. The aim of the project is to develop a new generation of ultra-sensitive magnetic sensors with very low noise based on magnetic tunnel junctions for Diagnosis and Healthcare applications. These elements will first be used to develop hybrid sensors able to detect femtoTesla fields for magnetic imaging of the human body, mainly heart and brain. Secondly, we will develop the next generation of magnetic based biochips. Finally we will explore a new approach for biochips based on fluctuating particles localized in space by dipolar reconstruction. The consortium is composed of three research and development institutes, two small and medium enterprises and a large scale industry. The main outputs of this project will be reliable, highly sensitive magnetic sensors for very different applications, hybrid sensors for femtoTesla field detection, a magneto-cardiographic (MCG) device, a new generation of magnetic based biochips and quantitative evaluation of dipolar reconstruction methods at the micron length scale.",Ultra sensitive Magnetic Sensors for medical applications,FP6,30 November 2008,01 December 2005,1421475.0 BIOMAP,Loughborough University,health,"This project proposes the development of a technology capable of delivering, high speed, simultaneous elemental and molecular maps of biological targets. Specifically these targets will include plaques associated with age-related macular degeneration (AMD), tumours treated with Pt-based chemotherapy drugs, and cell populations derived from the FP7 project, the ONE Study. The dual-mode imaging system will enable the analysis of metallo-proteins and their binding sites, or where there is no native metal tag or its abundance is too small to detect, anti-body or specific reactive chemistry metal or nano-particle tags will be added to the target molecules. For the ONE Study, one of the key project aims is to develop cell labelling strategies that will enable therapeutically administered cells to be tracked at low abundance in the host cell populations without toxic impact on either the therapeutic cells or host organism. The technology will be based on employing a common pulsed laser platform for laser ablation, desorption, or matrix assisted sampling of the target material simultaneously coupled with inductively-coupled plasma elemental mass spectrometry (ICP-MS) and ion trap organic mass spectrometry. In the case of the molecular mass spectrometry, electro-spray or matrix assisted charging will be used. The sampling will employ a technology developed in the host laboratory that enables targets to be sampled at atmospheric pressure whilst excluding atmosphere from the sampling point. The technology will be optimised for high speed and high efficiency to enable rapid mapping of targets at very high sensitivity. This will require development of a new high efficiency torch design for ICP-MS and the novel use of micro-jet pumps to deliver samples to the mass spectrometers. The project will also take advantage of the Fellow's expertise in synchrotron X-ray techniques to obtain non-destructive and comparative analyses of the specimen materials.",Simultaneous Elemental and Molecular Imaging of Biological Targets -A New Paradigm for the Study of Disease and its Treatment,FP7,12 March 2014,13 March 2012,210092.0 BIOMATE,Stichting Dienst Landbouwkundig Onderzoek * Foundation for Agricultural Research,health,"From a polymer chemistry perspective, the way in which nature produces its plethora of different proteins is a miracle of precision: the synthesis of each single molecule is directed by the sequence information chemically coded in DNA. The present state of recombinant DNA technology should in principle allow us to make genes that code for entirely new, very sophisticated amino acid polymers, which are chosen and designed by man to serve as new polymer materials. It has been shown that it is indeed possible to make use of the protein biosynthetic machinery and produce such de novo protein polymers, but it is not clear what their potentials are in terms of new materials with desired functionalities. I propose to develop a new class of protein polymers, chosen such that they form nanostructured materials by triggered folding and multimolecular assembly. The plan is based on three innovative ideas: (i) each new protein polymer will be constructed from a limited set of selected amino acid sequences, called modules (hence the term modular protein polymers) (ii) new, high-yield fermentation strategies will be developed so that polymers will become available in significant quantities for evaluation and application; (iii) the design of modular protein polymers is carried out as a cyclic process in which sequence selection, construction of artificial genes, optimisation of fermentation for high yield, studying polymer folding and assembly, and modelling of the nanostructure by molecular simulation are all logically connected, allowing efficient selection of target sequences. This project is a cross-road. It brings together biotechnology and polymer science, creating a unique set of biomaterials for medical and pharmaceutical use, that can be easily extended into a manifold of biofunctional materials. Moreover, it will provide us with fresh tools and valuable insights to tackle the subtle relations between protein sequence and folding.",Soft Biomade Materials: Modular Protein Polymers and their nano-assemblies,FP7,30 April 2016,01 May 2011,2497044.0 BIOMIM,Grenoble Institute of Technology * Institut polytechnique de Grenoble,health,"The main objective nowadays in the field of biomaterials is to design highly performing bioinspired materials learning from natural processes. Importantly, biochemical and physical cues are key parameters that can affect cellular processes. Controlling processes that occur at the cell/material interface is also of prime importance to guide the cell response. The main aim of the current project is to develop novel functional bio-nanomaterials for in vitro biological studies. Our strategy is based on two related projects. The first project deals with the rational design of smart films with foreseen applications in musculoskeletal tissue engineering. We will gain knowledge of key cellular processes by designing well defined self-assembled thin coatings. These multi-functional surfaces with bioactivity (incorporation of growth factors), mechanical (film stiffness) and topographical properties (spatial control of the film s properties) will serve as tools to mimic the complexity of the natural materials in vivo and to present bioactive molecules in the solid phase. We will get a better fundamental understanding of how cellular functions, including adhesion and differentiation of muscle cells are affected by the materials s surface properties. In the second project, we will investigate at the molecular level a crucial aspect of cell adhesion and motility, which is the intracellular linkage between the plasma membrane and the cell cytoskeleton. We aim to elucidate the role of ERM proteins, especially ezrin and moesin, in the direct linkage between the plasma membrane and actin filaments. Here again, we will use a well defined microenvironment in vitro to simplify the complexity of the interactions that occur in cellulo. To this end, lipid membranes containing a key regulator lipid from the phosphoinositides familly, PIP2, will be employed in conjunction with purified proteins to investigate actin regulation by ERM proteins in the presence of PIP2-membranes.",Biomimetic films and membranes as advanced materials for studies on cellular processes,FP7,31 May 2016,01 June 2011,1499996.0 BIOMIMEM,Claude Bernard University Lyon 1 * Université Claude Bernard Lyon 1,health,"Biological membranes play a central role in the living organization, but it is difficult to study protein-protein and protein-membrane interaction under controlled conditions inside of the living cells. Pioneering works have been carried out, indicating that biomimetic membrane systems such as lipid monolayers, liposomes, solid-supported or polymer-cushioned lipid membranes, can not only serve as biophysical models to study protein-protein and protein-membrane interactions, but also can be used to the design of biosensors and drug carriers. We feel it is extremely timely to form a partnership that combines researchers who have significantly contributed to this topic with the hope that our combined effort will lead a further and deeper understanding of the structure and functions of biological membranes. The IRSES project BIOMIMEM aims at connecting groups in the Germany (MPIKG), France (Lyon) and China (ICCAS and Harbin) which are working on biomimetic membrane systems. The exchange programme is organized into definite but complimentary 4 work-packages (WPs) that are executed by the combined effort of the above-mentioned 4 partners. This project brings together leading researchers with broad, complementary expertise: from biophysical chemistry, biochemistry, theoretical chemistry, to the more applicable aspects of nanobiotechnology, to form a team with the common goal of understanding the fundamental nature of biological membranes and developing new biosensors and drug carriers. Moreover, it will support and reinforce collaboration among the participants, help to educate young researchers, and help to develop and establish future long-term research collaboration between EU and China.",Biomimetic Membrane Systems,FP7,28 February 2014,01 March 2011,214200.0 BIOMOF,University of Liverpool,health,"This ERC-StG proposal, BIOMOF, outlines a dual strategy for the growth and processing of porous metal-organic framework (MOF) materials, inspired by the interfacial interactions that characterise highly controlled biomineralisation processes. The aim is to prepare MOF (bio)-composite materials of hierarchical structure and multi-modal functionality to address key societal challenges in healthcare, catalysis and energy. In order for MOFs to reach their full potential, a transformative approach to their growth, and in particular their processability, is required since the insoluble macroscopic micron-sized crystals resulting from conventional syntheses are unsuitable for many applications. The BIOMOF project defines chemically flexible routes to MOFs under mild conditions, where the added value with respect to wide-ranging experimental procedures for the growth and processing of crystalline controllably nanoscale MOF materials with tunable structure and functionality that display significant porosity for wide-ranging applications is extremely high. Theme 1 exploits protein vesicles and abundant biopolymer matrices for the confined growth of soluble nanoscale MOFs for high-end biomedical applications such as cell imaging and targeted drug delivery, whereas theme 2 focuses on the cost-effective preparation of hierarchically porous MOF composites over several length scales, of relevance to bulk industrial applications such as sustainable catalysis, separations and gas-storage. This diverse yet complementary range of applications arising simply from the way the MOF is processed, coupled with the versatile structural and physical properties of MOFs themselves indicates strongly that the BIOMOF concept is a powerful convergent new approach to applied materials chemistry.",Biomineral-inspired growth and processing of metal-organic frameworks,FP7,31 October 2015,01 November 2010,1492970.0 BIOMOFS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"This project will focus on the use of nanoporous metal organic frameworks (Fe, Zn, Ti) for bioapplications. These systems are exciting porous solids, built up from inorganic clusters and polycarboxylates. This results in open-framework solids with different pore shapes and dimensions, and applications such as catalysis, separation and storage of gases. I have recently initiated the synthesis of new trivalent transition metal carboxylates. Among them, the metal carboxylates MIL-100 and MIL-101 (MIL: Materials of Institut Lavoisier) are spectacular solids with giant pores (25-34 Ã…), accessible metal sites and huge surface areas (3100-5900 m2.g-1). Recently, it was shown that these solids could be used for drug delivery with a loading of 1.4 g of Ibuprofen per gram of MIL-101 solid and a total release in six days. This project will concentrate on the implication of MOFs for drug release and other bioapplications. Whereas research on drug delivery is currently focused either on the use of bio-compatible polymers or mesoporous materials, our method will combine advantages of both routes including a high loading and a slow release of therapeutic molecules. A second application will use solids with accessible metal sites to coordinate NO for its controlled delivery. This would provide exogenous NO for prophylactic and therapeutic processes, anti-thrombogenic medical devices, improved dressings for wounds and ulcers, and the treatment of fungal and bacterial infections. Finally, other applications will be envisaged such as the purification of physiological fluids. The project, which will consist of a systematic study of the relation between these properties and both the composition and structure of the hybrid solids, will be assisted by a strong modelling effort including top of the art computational methods (QSAR and QSPKR). This highly impact project will be realised by assembling experienced researchers in multidisplinary areas including materials science, biology and modelling. It will involve P. Horcajada (Institut Lavoisier), whose background in pharmaceutical science will fit with my experience in inorganic chemistry and G. Maurin (Institut Gerhardt, Montpellier) expert in computational chemistry.",Bioapplications of Metal Organic Frameworks,FP7,31 May 2013,01 June 2008,1250000.0 BIOMOLEC,High School of Lyon * École normale supérieure de Lyon,health,"The project will unite efforts of leading laboratories of 5 countries: France, Romania, Poland, Brazil and Russia to render the two well known biopolymers: DNA and collagen applicable in molecular electronics and in Photonics Marine DNA, extracted from waste in salmon industry and commercial collagen will be used to obtain biodegradable photoresponsive materials for application in photonics and in molecular electronics.Biodegradable and coming from renewlable ressources pure DNA and collagen, well known biopolymers, are chacterized by an ionic electrical conductivity and photoinactive large transparency range material. These materials will be functionalized with photoactive chromophores such as 1D charge transfer molecules to render them photoresponsive. On the other hand doping with such molecules as PEDOT, fullerenes and particularly the nanotubes will increase significantly the charge mobility and make the biopolymers applicable in optical signal processing, molecular electronics and solar energy conversion. At the output of the project materials with controllable charge mobility and nonlinar optical response will be obtained. Practical applications, particularly in solar energy conversion and in making smart windows will be demonstrated",Functionalized biopolymers for application in molecular electronics and in photonics,FP7,31 August 2015,01 September 2011,349200.0 BIOMONAR,University of Southern Denmark * Syddansk Universitet,health,"BIOMONAR develops multiplexed nanoarray biosensors for environmental targets, i.e. pollutants and pathogens. The innovative approach engineers three sensor platforms (surface, liposomal, living cell) which exploit a panel of periplasmic binding proteins (PBPs) as the common selective element. The nanoarrays are integrated into a microfluidics system for in-situ monitoring. The strategy allows for selective and sensitive detection of target compounds in complex environmental mixtures. The sensor platforms probe different aspects in the 'exposure to effect' chain of processes: each responds to a certain proportion of the total target concentration and has a characteristic dynamic window. The sensor signals are quantitatively interpreted and represented in terms of the spectra of reactivities and fluxes of the target compounds. This level of sophistication, coupled with the common PBP selective component, allows a coherent elucidation of the link between dynamic target speciation and predicted ecotoxicological impact. The optimisation and dedication of the sensors for environmental monitoring inherently involves physicochemical characterisation of the various bio/nonbio and bio/bio interfacial processes at nanoscale. The ensuing knowledge on the interaction of nanostructured surfaces with biological systems facilitates design of sensors for new targets, thus providing technical opportunities for the biosensor industry.",Biosensor nanoarrays for environmental monitoring,FP7,31 March 2014,01 April 2010,2997486.0 BIOMORPH,Queen Mary University of London,health,"There is great need for radically new paradigms that significantly push forward the complexity, multiscale control, and functionality of novel materials. Molecular self-assembling strategies are continuously being explored for developing ever more precise and organized materials. The development of adaptive materials that can be morphed into complex shapes of hierarchical structure through bottom-up mechanisms that mimic those found in tissue development is a fascinating possibility. This proposal (BIOMORPH) aims to develop a novel dynamic self-assembling material fabrication platform that combines the benefits of molecular self-assembly, bioengineering, nanotechnology, and tissue engineering. The system integrates simple peptide and protein building-blocks with multiple cells types to create complex hierarchical, biomimetic, hybrid structures that exhibit remarkable properties such as self-healing and the capacity to undergo morphogenesis. The work would represent a major step-change by developing a dynamic strategy based on emerging physico-chemical mechanisms that generate and dissipate stresses, and maintain a controlled non-equilibrium state that together is reminiscent of elements found in tissue morphogenesis. The work is divided in four work packages that expand from building block design and synthesis to biomechanical and in vitro assessment of the generated materials. The proposed fabrication platform may find applications in a variety of tissue engineering applications. However, as a first stage, the work proposes to grow tubes and tubular networks that recreate vascular tissue.",Novel dynamic self-assembling system: from hierarchical and biomimetic morphogenesis to functional materials,FP7,31 March 2018,01 April 2014,100000.0 BIOMUC,Claude Bernard University Lyon 1 * Université Claude Bernard Lyon 1,health,"Mucins are high molecular weight glycoproteins, responsible for most of the extraordinary properties of the mucosal layer, which covers around 300 m2 of our body's surface. Mucins have mostly been studied in the context of their physiological role: for their ability to protect the epithelial layer from viral and bacterial infection, oxidative degradation, dehydration and mechanical stresses. They are also of major importance in cancer biology, where altered mucin secretions are recognized as cancer markers. A few studies have focused on the interactions of 'objects' expected to diffuse from the exterior to the interior of the body through mucin gels, such as nutrients, antibodies, viruses and bacteria. This proposal describes how we will study the ability of mucin to sequester bioactive molecules secreted by cells surrounded by mucin. The goal is to investigate whether mucin gels can be a reservoir for bioactive molecules in a similar fashion to what the extracellular matrix is now recognized to be. The proposal describes a three-phase approach, which will both advance our knowledge on the physiological role of mucin gels and will lead to the development of innovative mucin-based biomaterials for drug delivery and tissue engineering applications. The first phase will focus on using 2D mucin coatings to study mucin interactions with relevant bioactive molecules. Also, structure/function will be investigated by modifying mucin chemistry. During the second phase, we will build multilayer thin films of hundreds of nanometer thick using lectin proteins as cross-linker between the mucin layers. The films will be characterized and their ability to act as a reservoir for drugs and other bioactive molecules will be assessed. Finally, in the return phase, we will combine the return host's expertise on natural based polysaccharide gels, and the knowledge accumulated on mucins. In particular, 3D hydrogels comprising mucin will be developed as a new biomaterials.",Mucin binding to bioactive molecules: physiological role and new biomaterials,FP7,31 March 2015,01 April 2012,280017.0 BION,University of Parma * Università degli Studi di Parma,manufacturing,"We shall use data from neuroanatomy and neurophysiology as a guide for the fabrication of deterministic and complex self-assembled networks of polymeric non linear elements with adaptive properties. The main objective is the realization of a new technology for the production of functional molecular assemblies, which can perform advanced tasks involving learning and decision making, and which can be tailored down to the nanoscale. The polymer network shall be prepared using molecular deposition and self assembly techniques in two and three dimensions. Electron beams shall be used for microelectrode configurations and for sample modification. Non linear elements will be provided by Schottky junctions, functionalized gold nanoparticles or molecular heterojunctions, which will be statistically dispersed in the matrix, to mimic the synaptic and neuronal distribution in biological systems as obtained from neuroanatomical data. We shall start with polyaniline embedded in ionic polyethyleneoxide, but other polymeric systems will be explored. The polymers will be functionalized to influence the deposition or self-assembly processes. To train the network we shall use mainly electrochemical modification of the polymer conductivity, for which we have already demonstrated the basic functional behaviour. . We shall monitor the network transfer function, for different types of signal input, including signal dependent noise. Artificial Intelligence algorithms and specifically developed statistical correlation techniques shall be used throughout. Upon success, the data shall be compared and connected to electrophysiological data obtained for brain systems of different complexity: first the simpler and more deterministic case of the pond snail and subsequently in the far more complex statistically distributed cases of cognitive processes in the cerebral cortex of the mammalian brain.",Synthetic Pathways to bio-inspired information processing,FP7,10 February 2012,04 March 2009,1303000.0 BIONANO-SWITCH,University of Portsmouth,manufacturing,"We seek to provide Europe with a major time advantage over their main international competitors by developing a bionanotechnological device that can be used as a nanoactuator/biosensor, which also provides a novel interface between the Biological and Silicon Worlds. The time advantage is provided by ?picking up? the highly successful Mol Switch Project (IST-2001-38036), in which we were able to show that biological molecular motors could be used as bio-nanoactuators. However, this project will push the frontiers of knowledge and skill by developing a useful generic biosensor/nanoactuator device. The device will be assembled in a series of stages using independent Modules that each incorporate new technology, or, expand the frontiers of existing technology. A prototype integrated biosensor will be built around this nanoactuator, incorporating the proposed Modules. The switching device within this nanoactuator is provided by a moving magnetic particle, attached to the DNA that is translocated (or ?pulled?) by the motor, and a suitable electronic sensor that detects this movement. Integration of these individual components into a single Module will provide a major step forward in the design of Lab-on-a-Chip technology. Therefore, we will seek to develop a microfluidics system that will allow us to incorporate the electronic sensor into a chip-based device. The project will also focus on the precise location and self-assembly of these motors and their DNA substrates within the microfluidics system to be used. The project will involve partners who will focus on the further development of the electronic sensor. We know of no other bionanotechnological device, which incorporates biological molecular motors to produce moving parts, that is as far advanced as this project offers and, therefore, we believe the project will provide the EU with a significant advance in this area.",A Biological Nanoactuator as a Molecular Switch for Biosensing,FP6,15 April 2010,16 October 2006,1992609.8 BIONANODIAMOND,University of Warwick,health,"The detection of specific sequences of DNA is pivotal in the diagnosis of a number of infectious diseases, such as chlamydia. It is also important in detecting and identifying potential bio-warfare agents. Current methods of DNA detection typically involve laboratory based sample analysis, which is slow and costly. This proposal seeks to address these drawbacks by developing an alternative approach based on nanopore unzipping. In this method the current-time transient is recorded for a single molecule of dsDNA as it denatures and passes through a protein pore. The current as the DNA blocks the pore, as well as the time taken for the dsDNA to 'unzip' (denature) is characteristic of the DNA sequence, length and the presence of any modifications. The proiten pore itself must be suspended in a lipid bilayer across a nm-diameter orifice that acts as a platform. Whilst identification of DNA targets with nanopore unzipping is expected to be quick and efficient, the platforms typically used for such measurements (mainly silicates) are fragile and lack bio-compatibility. This proposal seeks to bring the power of nanopore unzipping outside of the laboratory through the development of a robust, ultra-stable, platform constructed from diamond. The research conducted during this proposal could lead to a commercially viable device capable of detecting and identifying DNA at the point need, for example in medical diagnostics in a hospital or identifying potential bio-warfare agents in the field of operation.",The development of a diamond-based nanopore sensor for the detection and identification of DNA,FP7,05 April 2017,06 April 2014,282109.0 BIONANOMUTT,University of Leeds,health,"Nanomedicine is an interdisciplinary field of research that aims to use nanotechnology to improve the pharmacokinetic profile of therapeutics and/or the contrast and information from medical imaging and diagnostics. The advances in medical treatments that nanomedicine strategies will provide will have a significant socioeconomic impact for the E.U. and is particularly timely due to the aging populations in E.U. member states. This work will use a multi-strategy approach to design novel multicompartmental, multifunctional nanoarchitectures for nanomedicine applications. Lipid nanodiscs will be evaluated as a novel hydrophobic drug carrier and the versatility of the scaffold protein for these discs will be explored by assessing its capacity to form similar complexes with synthetic block copolymers. Multicompartmental, size-limited nanostructures will be developed by using the self-organisation of functional amphiphiles into anisotropic subunits as building blocks for superstructures of greater complexity and functionality. The basic building blocks explored will consist of liposomes, polymersomes and hydrid lipopolymersome structures as well as protein-stabilised lipid nanodiscs. This project will also explore incorporating quantum dots into these nanoarchitectures as an added imaging modality. Finally, through multidisciplinary collaboration of basic scientists through to clinicians, an adjuvant nanomedicine therapy will be developed for treatment of superficial bladder cancers. These therapeutic nanoparticles will contain therapeutic, imaging and active targeting functionalities to remove residual malignant cells following the surgical resection of tumours.",Multi-compartmental Biomolecular Nanocarriers for Multi-modal Targeted Therapies,FP7,30 September 2015,01 October 2011,100000.0 BIONANOPORE,Technische Universiteit Delft * Delft University of Technology,health,"Compartmentalization of the eukaryotic genome into a nucleus necessitates nuclear import and export to achieve basic cellular processes. The nuclear pore complex (NPC) is a large (60 - 125 MDa) macromolecular structure in eukaryotic cells, where it spans the nuclear membrane and serves as the gatekeeper of nucleocytoplasmic transport. While water, ions, and small molecules can freely diffuse through the NPC, macromolecules larger than 25 - 40 kDa cannot pass the NPC's permeability barrier unless ferried by specific transport proteins called nuclear transport receptors (NTRs). While the structural arrangement and biochemistry of the complex have been largely worked out, the underlying mechanism of the pore's transport and selectivity remains poorly understood. Mechanistic studies of the NPC have been largely carried out in vivo because in vitro reconstitution of the complex is not possible. Here, I propose to develop a biomimetic NPC-like system based on solid-state nanopore technology to conduct a real-time, single-molecule investigation into the mechanism of NPC transport and selectivity. Both electrical detection and a novel optical-electrical method will be used to monitor the translocation of individual substrates through a single biomimetic pore. The biomimetic approach proposed here will provide a significant step forward in experimentally studying the NPC, by affording an in vitro system that will allow for rigorous testing of key NPC proteins and their mechanistic role in transport and selectivity. This work will be carried out in the laboratory of Professor Cees Dekker, who is a world leader in nanofabrication and the application of solid-state nanopores to biology. My expertise in single-molecule biophysics, fluorescence microscopy, and biochemistry is well suited to complement the resources of the Dekker lab to collectively meet the interdisciplinary demands of this innovative effort.",Biomimetic nanopore for a mechanistic study of the nuclear pore complex,FP7,31 May 2013,01 June 2011,185540.0 BIONANOSMART_DDS,University of Santiago de Compostela * Universidade de Santiago de Compostela,health,"This initiative aims to gain both fundamental understanding and applied knowledge on novel polysaccharide-based nanoparticles to be utilized as 'smart' advanced delivery systems of therapeutic biomacromolecules for oral administration. To this end, nanoparticles will be harnessed from chitosan and other polyionic polysaccharides of biomedical use, cross-linked with a natural non-toxic biocompatible agent. Sensitivity to changes in temperature and pH will be conferred by modifying the surface charge (zeta potential) by modifying the local hydrophilic/hydrophobic balance the nanoparticle surface. While sensitivity towards two biomolecules of therapeutic significance will be achieved by modifying the nanoparticle surface by molecular imprinting, using a non-covalent approach. Phase transitions in these systems will be investigated by means of biophysical techniques including dynamic light scattering and SAXS (small-angle X-ray scattering). The adsorption capacity and selectivity of the molecularly imprinted surface will be studied by quartz crystal micro balance with dissipation mode (QCM-D) techniques. The in vitro release profile will be evaluated as a function of the presence of the external stimuli (temperature, pH and concentration of specific molecules). Citotoxicity and cell uptake will be evaluated in Caco-2 cell monoculture and the biopharmaceutical performance will be evaluated for selected prototypes after oral administration in a rat model.the biopharmaceutical performance will be evaluated after oral administration in a rat model.",Biopolymer-Based Nanoparticle 'Smart' Drug Delivery Systems and their Biopharmaceutical Application by Oral Administration,FP7,30 September 2010,01 October 2008,216049.0 BIONANOTOOLS,IMDEA Nanoscience Institute * IMDEA Nanociencia,health,"The main objective of my research project is to understand how the structure and function of proteins are defined by their sequence and to apply learned rules to design new protein-based nanotools. In particular, I will focus on a type of proteins called tetratricopeptide repeats (TPR). They present a simple modular structure, where a small structural unit is repeated in tandem. Overall TPR domains are a very robust system to study protein structure, folding, and function, and to use them as building blocks for protein engineering to generate new functional nano-molecules. I aim to study natural TPR domains that mediate protein-protein interactions at a molecular level, and extract basic principles that govern these interactions to apply them in the design of TPR units with desired specific activities. I will also perform basic studies on protein stability and folding of designed TPRs to gain a better understanding on how the protein sequence determines thermodynamic stability. These studies will allow us to generate more stable proteins that will be useful in biotechnological applications, such as generation of novel biomaterials. The ability to discriminate between residues that determine the structure and stability, from those responsible of the binding specificity in the protein scaffolds, together with the capacity to generate super-stable scaffolds, opens the door to the generation of protein libraries. In such libraries only the binding sites will be randomized in order to incorporate a wide variety of potential specificities, and will be screened against different targets of interest using high-throughput methods. We will design functional proteins with defined binding-specificities and structural properties. These novel bio-tools will be extremely useful to monitor and investigate biological processes in vivo, as biosensors for diagnosis to detect disease biomarkers, and also as building blocks for applications in biomaterials design.",Protein design to generate bio-functional nanostructures,FP7,30 June 2014,01 July 2010,100000.0 BIONEL,Lund University * Lunds Universitet,health,"BIONEL is a Marie Curie EST site at Lund University involving Analytical and Biochemistry/Biotechnology/Applied Microbiology/Cell-Organism/Neural Stem Cell Biology/Restorative Neurology/Solid State Physics. The aim is to provide early stage research training in Bioanalytical Chemistry/Bionanotechnology/Bioelectrochemistry for stays from 9 months to a full PhD. The scientific content can be summarised as: Global parameters such as bioavailability/toxicity can only be assayed using living cells. The determination of these parameters motivates the objective of this project: to develop tools to monitor dynamic cellular processes with electrochemistry through (i) development of amperometric and impedance procedures for monitoring cell membrane integrity, redox signalling, and exocytosis. Focus will be at obtaining and understanding mediated and (possibly direct) electrochemical communication with both pro-and eukaryotic cells (ii) development of nano-Interdigitated Electrodes (IDE) for characterisation of exocytosis of catecholamine neurotransmitters from neurons, (iii) elaboration of methods for stem cell differentiation into different phenotypes by monitoring exocytosis using IDE arrays, (iv) encapsulation of cells into layer-by-layer built polymers for cell stabilisation and self-assembling on IDEs, (v) development of cell and tissue based arrays. All fellows will work in projects involving at least two different disciplines under supervision of full and/or associate professors and with state-of-the-art equipment. Additional training in presentation skills, undergraduate supervision, safety, management will be provided. As a result of the training, all fellows will be able to publish scientific papers in peer reviewed international periodicals. The infrastructure will be open for the fellows with access to Internet, e-mail, remote databases etc. as well as advanced and graduate courses.",Bioanalytical Electrochemistry and Bionanotechnology 'BIONEL',FP6,31 December 2008,01 January 2005,1185831.0 BIONEMS,Consejo Superior De Investigaciones Científicas (CSIC),health,"The aim of the project will be the development of biochip plailbtms based on micro- and nanotechnology for functional genomics and proteomics. The linai microsystems will be composed of biological nanosensors, optical and electric transducers, microfluidics and CMOS circuitry for signal processing. Integration of these units will result in both miniaturization of biochip platforms and an increase in the sensitivity of the assays performed. The resulting Nanobiochips will present several advantages, like low reagent consumption, short analysis time, real-time monitoring and high sensitivity. Also, the biological nanosensors will allow direct detection, avoiding the problems associated with fluorescent and radioactive labeling used nowadays. The portable biosensor microsystem will be mainly applied in the biomedical field, where mobility implies a significant improvement for health monitoring. Among the applications are the detection of combined markers for diagnosis and follow-up of prostate, breast and endometrial cancers. The key element of the biosensor microsystem for specific biological detection will be the nanomechunical response of an array of micro- nanocantilevers. Briefly, the operation principle in pharmacogenctic applications is as follows. Nucleic acids are covalently immobilized on the surface of a micro- nanoeantilever. When the micro- nanocantilevers are exposed to a medical sample, in which a nucleic acid with the complementary nucleotide sequence is present, this will hybridise with (he immobilized nucleic acid. This will give rise to a change of surface stress and mass of the micro- nanoeantilever that is translated into a nanomechanical response, i.e., a cantilever bending and a change of its resonant properties that can be measured. Also, changes in surface stress can be measured directly through integrated piezoresistors in the cantilevers.",Nano-electromechanical systems for biomedical applications,FP6,31 May 2005,01 June 2004,40000.0 BIONLIGHT,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"BioNLight has been designed to investigate the prospective of commercially exploiting our multimodal nanoparticle technology in the biological imaging market. The introduction of this technology will open up an entirely-new window of molecular imaging possibilities, thereby supporting advances in biology, drug discovery & development and diagnostics. Funded by ERC, Prof. Brunsveld and colleagues have developed modular nanoparticles that exactly address the needs of the molecular imaging field. These nanoparticles of organic nature can be produced in a reproducible one-step method by self-assembly in water. The result is a highly-robust and biocompatible nanoparticle that can be modulated to emit any desirable colour frequency with long-term emission and high photostability. Moreover, they can be functionalised with multiple ligands thanks to great control over surface functionality and can be prepared not only for fluorescent studies, but also for other imaging technologies. In practise this implies that the technology platform can be used to advance a wide range of in-vitro and in-vivo assays and to visualise yet-uncovered processes. It is the objective of BioNLight to select the most interesting applications for commercialisation and to build up a prospectus that can be used to convince future customers of the practicability and the imaging power of our technology platform. Besides, we aim to construct a sound business model and strategy for commercialisation. This will be done by external validation of the nanoparticles by industry followed by final optimisation, by means of an extensive market study, by building a strong IP position and by setting up a business plan with detailed financial feasibility projections. The ERC Proof of Concept Grant will enable us to take the ERC Starting Grant results to a sound business proposition.",Targeting the biological imaging market with multifunctional fluorescent nanoparticles,FP7,31 July 2013,01 August 2012,149990.0 BIOPHOT,University of Namur * Université de Namur,photonics,"The physical explanation of the extraordinary appearances of many living entities faces complexity. Using a combination of microscopy techniques, we wish to develop a knowledge of the micro- and nano-morphology of specific bio-organisms, selected for their particular ability to use light scattering as part of their living mechanisms.This knowledge will be complemented by the precise characterization of the light filtering functions of the structurated organs, making use of micrometer-resolved spectrophotometric and thermal exchange measurements.The relation between these and the optical density will be consolidated by large-scale numerical simulations.On the other hand, the targeted organisms will be studied from the point of view of ecological and phenological history. In particular, closely related, or competing species will be designated for further physical examinations. Interdisciplinary exchanges, including, when available, paleontological data, will attempt to determine whether the optical scattering mechanisms constitutes a possible evolutive advantage which could explain the permanence of the bio-organism in its ecosystem.With regard to the problem of complexity,different methods will need to be developed at each stage of the investigation.The study of the bio-organism in its environment,eventually at different evlolutinary epochs,will require an analysis of a large number of interactions and dependencies among living populations; the experimental and theoretical study of the light-filtering functions will also cope with complexity, as it requires to account for a multi-dimensional hierachical data set, including the knowledge of reflection, absorption and, polarization changes as a function of frequency, incidence and emergence angles, at various points of the bio-organism surface.The understanding of such hierarchical assemblies of elements with several length-scales is expected to provide guidance for the design of synthetic structures",COMPLEXITY AND EVOLUTION OF PHOTONIC NANOSTRUCTURES IN BIO-ORGANISMS: TEMPLATES FOR MATERIAL SCIENCES,FP6,30 April 2008,01 May 2005,1493993.7 BIOPOLTRONIC,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,energy,"Recent developments of chemical and biological sensors require semi-conducting (conjugated) polymers preferably processible from environmental-friendly solvents like alcohols and with an affinity towards the physiological medium of the analyte (water). The objective of the project is to develop at IMEC, through transfer of knowledge, competences and know-how in the synthesis of ionic conjugated polymers (ICPs): amphiphilic and polyelectrolytes. ICPs feature ionic or polar side groups, which render the materials soluble in water and/or alcohols, and possess an intrinsic tendency to organize into supramolecular architectures in solution and in solid state, which make them promising candidates as a platform for the development of chemo- and biosensors. The new semi-conducting polymers will be designed in order to achieve a control of the nanoscale morphology and will be based on poly(p-phenylene vinylene) derivatives (PPVs) substituted with ionic or polar side chains.They will be synthesised using the 'precursor sulphinyl route' developed at IMEC for the synthesis of 'classical' PPVs. Monomer synthesis and polymerisation methods will be developed and optimised for environmental-friendly solvents. These new materials will be evaluated in various device structures as Light Emitting Devices (PLED), organic transistors, organic photovoltaics and in chemical and biological sensors. This will result in a thorough characterisation of the electrical properties of the ICPs under study. To reach that goal two types of expertises will be required over two years: 36 person-months of organic and polymer chemists preferably with a background in conjugated polyelectrolytes and/or amphiphilic polymers, and 18 person-months of an electronic engineer or material physicist with abackground in organic semi-conductors. In Europe the efforts put in this new field are promising but still significant lower compared to what is done in the United States and Japan.",Development and characterisation of new semi-conducting polymers soluble in environmental-friendly solvents for self-assembled nanostructures and application in advanced electronic devices.,FP6,31 May 2006,01 June 2004,318501.0 BIOPOLYSURF,University of Valladolid * Universidad de Valladolid,health,"The enormous potential of Biology in combination with Chemistry and Physics will lead to break-through advances in material science and to an abundant wealth of exploitable developments, Chemistry and Physics offer advanced tools for synthesis, characterization, theoretical understanding and manufacture of materials and devices, while Biology offer a window into the most sophisticated collection of functional nanostructures that exist. The inspiration searched in Nature will expand not only lo the use of the characteristics of the biological molecules but also to the clean, self-sustainable and efficient way that Nature produces such sophisticated molecules, The project of Biopolysurf aims at providing a platform for research and training In this multidisciplinary field. Biopolysurf is a RTN planned to facilitate the exchange of expertise and knowledge between top-notch groups coming from these three traditional disciplines as a way to achieve a privileged excellence in Nanobiotechnology and to establish a high quality training and truly multidisciplinary platform for young and experienced researches. Our main goal will be the engineering of advanced nanofunctionalized polymeric surfaces for smart systems in biomedicine, biology, material science and nanotechnology by assembling molecules and nano-objects into functional patterns. Biopolysurf is intended as an application-oriented research network. All the tools and knowledge developed within the network will be focused on marketable products. The aimed tasks are designed to be used in tissue engineering, drug (gene) delivery, nanobiotechnology, lab-on-a-chip systems and advanced smart materials and devices for agriculture, food packaging, cosmetics, etc. The interdisciplinary approach of Biopolysurf will establish a complete chain of knowledge: It ranges from innovative concepts for the design and the (bio) synthesis of novel materials to the fabrication of controlled (ordered) nanostructures via self-assembly.","Engineering advanced polymeric surfaces for smart systems in biomedicine, biology, material science and nanotecnology: A cross-disciplinary approach of Biology, Chemistry and Physics",FP6,30 September 2008,01 October 2004,3473926.0 BIOPROBE,IBM Research GmbH,health,"Life is fundamentally characterised by order, compartmentalisation and biochemical reactions, which occurs at the right place right time -within, on the surface and between cells. Only a proportion of life processes can be addressed with contemporary approaches like liquid encapsulations (e.g. droplets) or engineering compartments (e.g. scaffolds). I believe these approaches are severely limited. I am convinced that a technique to study, work and locally probe adherent cells & tissues at micrometer distances from cell surfaces in 'open space' would represent a major advance for the biology of biointerfaces. I therefore propose a non-contact, scanning technology, which spatially confines nanoliter volumes of chemicals for interacting with cells at the µm-length scale. This technology called the vertical microfluidic probe (vMFP) -that I developed at IBM-Zurich -shapes liquid on surfaces hydrodynamically and is compatible with samples on Petri dishes & microtiter plates. The project is organized in 4 themes: (1) Advancing the vMFP by understanding the interaction of liquid flows with biointerfaces, integrating functional elements (e.g. heaters/electrodes, cell traps) & precision control. (2) Developing a higher resolution method to stain tissue sections for multiple markers & better quality information. (3) Retrieving rare elements such as circulating tumor cells from biologically diverse libraries. (4) Patterning cells for applications in regenerative medicine. Since cells & tissues will no longer be limited by closed systems, the vMFP will enable a completely new range of experiments to be performed in a highly interactive, versatile & precise manner -this approach departs from classical 'closed' microfluidics. It is very likely that such a tool by providing multifunctional capabilities akin to the proverbial 'Swiss army knife' will be a unique facilitator for investigations of previously unapproachable problems in cell biology & the life science.",VERTICAL MICROFLUIDIC PROBE: A nanoliter 'Swiss army knife' for chemistry and physics at biological interfaces,FP7,31 December 2017,01 January 2013,1488600.0 BIOPTRAIN,University of Nottingham,health,"Completion of the sequencing of the entire human genome and other major technological advances in bioinformatics have opened up a huge range of scientific challenges that will need to be addressed in order to maintain Europe's scientific and commercial competitiveness and effectiveness in this emerging area of healthcare. An FP6 Network of Excellence, BIOPATTERN, has been established to integrate leading institutes around Europe to form a virtual institute for the study of individualised healthcare. The overall grand vision of BIOPATTERN is to integrate the analysis of nano level bioinformatic data with micro level biosignal data and macro level patient information data in a pan-European cooperative reseach effort to combat major disease classes. Selected members of BIOPATTERN will form the core of the BIOPTRAIN EST, the aim of which is to establish a complementary wide-ranging training programme of world-class quality in bioinformatic optimisation algorithms. This will bring together academics from Univeristy of Nottingham (UK), University of Florence (Italy), Katholieke Universiteit Leuven (Belgium), University College of Boras (Sweden) and Poznan University of Technology (Poland) to form the necessary multi- and interdisciplinary team to deliver a programme narrow in focus (computational algorithms for optimisation of bioinformatic problems), yet broad in influence and perspective (with contributions from many disciplines including computer science, chemistry, biology, medicine, etc.). There are two crucial groups of beneficiaries: (i) the next generation of European scientists will be trained to take advantage of the latest advances in bioinformatics with an aim of creating a vibrant, future-proof and self-sustaining research effort; and (ii) the European citizen will be targeted to benefit from bioinformatics advances worldwide - we cannot depend on research communities in the USA and elsewhere to meet the specific needs of European healthcare.",Bioinformatics Optimisation Training,FP6,31 August 2009,01 September 2005,2121547.0 BIOQ,University of Ulm * Universität Ulm,health,"Many of the most remarkable contributions of modern science to society have arisen from interdisciplinary work of scientists enabling novel imaging and sensing technologies (NMR, X-ray diffraction, electron microscopy). BioQ will revolutionize the state of the art to create novel sensing technologies for the broad field of life sciences research that provide unprecedented access and insight into structure and function of individual bio-molecules under physiological conditions and apply these to the observation of biological processes down to the quantum level and with atomic resolution. At this level quantum properties are predicted to play an important role for the function of biological systems subject to environmental noise. BioQ will unravel the interplay of quantum coherent dynamics, molecular vibrations and environmental noise due to molecular vibrations in biological processes and design and carry out experimental tests of its predictions. BioQ will achieve new levels of understanding and control of biological systems, culminating in new ways to interface biological systems with quantum devices. To this end BioQ will exploit the ability of biological systems to arrange themselves into highly ordered structures to form novel hybrid materials of functionalized nano-diamonds that are capable of harnessing complex quantum dynamics at room temperature. A deeper understanding of biological processes will open new roads towards drug design and bio-imaging. The elucidation of energy transport processes and dynamics may pave the way towards the design of more efficient light harvesting systems. Self-assembled hybrid bio-quantum devices provide a novel perspective towards quantum nanotechnology. The broad challenges that this ambitious programme present will be solved by an interdisciplinary team led by three PIs from experimental solid-state physics, theoretical quantum physics and bio-chemistry whose combination of expertise is essential for the success of BioQ.",Diamond Quantum Devices and Biology,FP7,30 June 2019,01 July 2013,1.0293309E7 BIORA,Carl von Ossietzky University of Oldenburg * Carl von Ossietzky Universität Oldenburg,health,"The project 'Biomedical Robotics and Applications (BioRA)' focuses on the staff exchange between the partners of EU and China, and on the development of new technologies and applications in the field of biomedical robotics on the macro, micro and nano scales for biological cell detection, manipulation, test and injection. It meets the objectives and requirements of the Marie Curie Action: International Research Staff Exchange Scheme (IRSES), by setting up multiple bridges between European and Chinese institutions. The ultimate goal of BioRA is to establish a long-term research cooperation platform between Europe and China in the challenging field of biomedical robotics with promising applications in scientific, industrial and domestic sectors. The synergistic approach made by BioRA will keep the consortium's leading position in the world for potential major scientific and technological breakthroughs in biomedical robotics and biomedical applications. The project is divided into five inter-related workpackages: (1) Setup of knowledge base and road mapping, (2) Fundamental exploration of biomedical robotics, (3) Development of biomedical robot components and systems, (4) Dissemination and exploitation, and (5) Project management. The workpackages integrate all activities that will lead to the completion of all the project objectives within 48 months.",Biomedical Robotics and Applications,FP7,31 December 2017,01 January 2014,445200.0 BIOSCA,Complutense University of Madrid * Universidad Complutense de Madrid,health,"Calcium phosphate ceramics have been used in medicine for more than 20 years because of its similarities to bone apatite. Bone repair and regeneration occurs along its surface and porous structures permits bone ingrowths acting as a scaffold in bony tissues sites. As well as these ceramics, bioactive glasses and biocompatible polymers are widely used but all of them present low strength and poor fatigue resistance to be implanted as high load bearing devices. In order to seek better ways of processing biomaterials, so that both mechanical properties and porosity could be optimized, devices have been design combining HA with other materials, however, significant amounts of the reinforcing phases are needed to achieve the desired properties, and as these parts are significantly less bioactive than HA, or bioreabsorble, the ability of the composite to form a stable interface is poor compared to HA itself. An ideal reinforcement material would impart mechanical integrity without diminishing its properties. This project envisages the use of carbon nanotubes (CNTs) as reinforcement material for the bioactive ceramics and to use their ability as drug delivery systems of pharmacological active molecules (osteogenic, antitumoral, antiviric,…) or as smart materials (able to change their properties as a function of the medium). In relation to this, the addition of CNTs to the base composite produces a three-dimensional electrical conducting network, property as has already been reported, could be used to provide electrical stimulation and increase of cellular proliferation.",Intelligent and reinforced tissue scaffolds for regenerative biomedicine,FP7,30 April 2011,01 May 2008,45000.0 BIOSCENT,University of Pisa * Università di Pisa,health,"Congenital and acquired diseases of the heart are the leading causes of morbidity and mortality in the world today; 7.2 million people die each year due to coronary heart disease, being the first cause of mortality in population above 60 years old, and the second cause after HIV in world wide young population. There is an urgent demand for new methods to repair and replace damaged cardiovascular tissues. One of the most promising ways to achieve this goal is the development of regenerative therapies aided with novel intelligent nanobiomaterials such as bioactive scaffolds. The overall objective of this project is the development of innovative bioactive polymeric scaffolds able to guide tissue formation from dissociated stem cells, for engineering autologous cardiovascular replacements, namely vascular tissues, heart valves and cardiac muscle. Two different strategies will be followed to approach creating new engineered tissue: 1.In vitro tissue engineering: according to the most frequent tissue engineering paradigm, cells will be seeded on a scaffold composed of synthetic polymer or natural material and the tissue will be matured in vitro in a bioreactor, in order to obtain a construct that can be implanted in the appropriate anatomic location as a prosthesis; 2.In vivo tissue engineering: unseeded scaffolds that attract endogenous cells and control cell proliferation and differentiation will be implanted to repopulate and remodel an altered cardiovascular tissue. The strong innovative content of the project is in the realisation of multifunctional scaffolds which can guide complex cellular processes such as adhesion, proliferation and differentiation, processes fundamental for tissue regeneration. It is therefore necessary to design integrated material scaffolds and culture environments, which can appropriately confer biochemical, morphological, electrical and mechanical stimuli to a developing tissue.","BIOactive highly porous and injectable Scaffolds controlling stem cell recruitment, proliferation and differentiation and enabling angiogenesis for Cardiovascular ENgineered Tissues",FP7,31 December 2013,01 January 2009,6305731.0 BIOSENSORS-AGRICULT,University of Latvia * Latvijas Universitāte,health,"The key objective of the 'DEVELOPMENT OF NANOTECHNOLOGY BASED BIOSENSORS FOR AGRICULTURE' project is the coordinated transfer of knowledge and training activities between participating teams in the EU (Riga, Linkoping, Montpellier), in the Ukraine (Odessa and Kyiv) and the Belarus (Minsk) with the aim of strengthening the existing scientific partnerships and developing new collaboration for long lasting synergy, and to enhance the scientific excellence of participating early stage and experienced researchers. The transfer of knowledge and forming of an intellectual 'critical mass' will occur through theoretical exercises and laboratory research in the important and growing field of optical fibre biosensors, aiming towards applications in agriculture and taking opportunities offered by the latest achievements in nanotechnology and biotechnology. The challenge is to create a unique devices for detecting animal diseases, viruses and toxins using fundamental phenomena such as light absorbance, reflectance, transmittance, fluorescence and photoluminescence. The consortia have theoretical and experimental experience and specific skills for making advances in research on biosensors for agriculture applications. The aim is to amplify their knowledge and skills via joint research on specific tasks in work packages and to ensure the transfer of knowledge via seminars, workshops and summer schools and training courses. Through these, the results will be disseminated effectively and interactions will be stimulated amongst experienced researchers and community of young researchers, PhD and MSc students. Mutual research efforts and contacts, including cross-generation interactions, young researchers meetings and appropriate creative environment will grant necessary pre-conditions for sustainability of cooperation among consortia partners after the project is concluded. In total 164 secondment months are planned, 7 summer schools or training courses and 2 conferences.",DEVELOPMENT OF NANOTECHNOLOGY BASED BIOSENSORS FOR AGRICULTURE,FP7,31 August 2016,01 September 2012,292600.0 BIOSILICA,University Medicine of the Johannes Gutenberg-University Mainz * Universitätsmedizin der Johannes Gutenberg-Universität Mainz,health,"During the last decade, the principles of biomineralization have increasingly attracted multidisciplinary scientific attention, not only because they touch the interface between the organic/inorganic world but also because they offer fascinating bioinspired solutions to notorious problems in the fields of biotechnology and medicine. However, only one group of animals has the necessary genetic/enzymatic toolkit to control biomineralization: siliceous sponges (Porifera). Based on his pioneering discoveries in poriferan molecular biology and physiological chemistry, the PI has brought biosilicification into the focus of basic and applied research. Through multiple trendsetting approaches the molecular key components for the enzymatic synthesis of polymorphic siliceous skeletal elements in sponges have been elucidated and characterized. Subsequently, they have been employed to synthesize innovative composite materials in vitro. Nonetheless, knowledge of the functional mechanisms involved remains sketchy and harnessing biosilicification, beyond the in vitro synthesis of amorphous nanocomposites, is still impossible. Using a unique blend of cutting-edge techniques in molecular/structural biology, biochemistry, bioengineering, and material sciences, the PI approaches for the first time a comprehensive analysis of natural biomineralization, from gene to biomineral to hierarchically ordered structures of increasing complexity. The groundbreaking discoveries expected will be of extreme importance for understanding poriferan biosilicification. Concurrently, they will contribute to the development of innovative nano-biotechnological and -medical approaches that aim to elicit novel (biogenous) optical waveguide fibers and self-repairing inorganic-organic bone substitution materials.",From gene to biomineral: Biosynthesis and application of sponge biosilica,FP7,31 May 2016,01 June 2011,2183600.0 BIOSILICA FORMATION,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"We propose to use sum frequency generation (SFG), near edge X-ray absorption fine structure (NEXAFS) and solid state NMR spectroscopy to explore the structural basis for the control exerted by basic peptides on biosilica morphology. The long-term objective of this research is to elucidate the molecular recognition mechanisms used by proteins to control biomineralization processes. The questions we ask are: What is the structural basis for protein recognition of their native mineral phases? What structural motifs do proteins use to interact with mineral phases, and what amino acid side chains orient proteins at mineral interfaces? Answers to these questions would expand not only our understanding of the role played by proteins in biomineralization, but would also provide clear structure-based principles for the design of biomaterials and biomedical devices. However, due to the difficulties in studying protein structure and function at inorganic solid surfaces, there is still remarkably little known of the molecular structure-function relationships that govern hard tissue engineering by proteins. We know far less about the structures of proteins at biomineral interfaces than we know about the structures of membrane proteins. In this proposal we focus on protein regulation of biosilica morphology. It is widely recognized that proteins regulate formation of silica- based cell walls in diatoms. We propose to use a variety of spectroscopies that we have adapted for use in studying biomaterials, to determine how proteins direct the formation of silica-based nanospheres, nanotubules and other structures.",A Multi-Spectroscopic Investigation of Protein Structure in Biosilica Composites,FP7,31 August 2016,01 September 2012,100000.0 BIOSOFT,Polytechnic University of Milan * Politecnico di Milano,manufacturing,"This research proposal is aimed to investigate, by means of light scattering and other optical investigation methods, self-aggregation effects and interparticle interactions in solutions of bio-functionalized surfactants. These compounds have an amphiphilic structure with biologically-inspired head groups (made for instance by a small number of nucleosides). As a consequence, they behave as “smart†molecules capable of specific molecular recognition of a complementary head-group sequence, which makes them particularly appealing for the development of bio-nanotechnologies. Indeed, by appropriate control of the chemical functionalities codified in molecular structure, bio-functionalized amphiphiles self-assembly as micellar systems, vescicles, microemulsions, “living polymersâ€, or chiral structures, and can be used to design host-guest complexes and systems for enzymatic confinement. Main goal of the project is trying and establishing a link between the collective, non-specific, large-scale self-assembly phenomena that are usually investigated by soft matter scientists, and the short-range molecular specificity effects commonly seen as the driving force for association in biological fluids.",LIGHT SCATTERING INVESTIGATION OF BIO-FUNCTIONALIZED AMPHIPHILES,FP6,14 July 2007,15 July 2006,40000.0 BIOSURFING,Ghent University * Universiteit Gent,health,"This project aims to create new-to-nature and tailor-made biosurfactants through metabolic engineering of the unconventional yeast Candida bombicola. Biosurfactants produced by fermentation offer a worthy alternative to traditional surfactants, which are typically derived from non-renewable petrochemical resources and may cause environmental problems due to their ecotoxicity and poor biodegradability. Despite the clear advantages of biosurfactants, their overall use is hampered by the lack of structural variation. This is in sharp contrast to chemically produced surfactants where one can introduce variation by simply changing the building blocks. Structural variation is essential as (bio)surfactants find application in a very broad range of sectors. This project aims to alleviate this fundamental limitation by developing a generic biotechnological production technology for glycolipid biosurfactants. This will in turn significantly broaden the range of commercial biosurfactants, satisfying the need for structural diversity in the market. It is expected that this technology will result in a breakthrough penetration of glycolipid biosurfactants in the overall surfactant market, in this way helping to build the bio-based economy. Indeed, biosurfactants are a promising target for the biobased economy as the world surfactant production exceeds 13 Mton/year and is meanly based on petrochemical raw materials. The very efficient biosurfactant producing yeast C. bombicola will be metabolically engineered such that all structural parts of the glycolipid biosurfactant molecule can be controlled: fatty acid tail, sugar moiety, acetylation and lactonization. New technology for metabolic engineering of unconventional organisms such as the use of meganucleases will be developed and strains will be evaluated by several 'omics' approaches: proteomics, transcriptomics and metabolomics . Metabolically engineered production strains equipped with new combinations of genes and pathways will synthesize tailor-made and new-to-nature biosurfactants. For each target molecule, a fermentation process will be developed and the molecules will be evaluated for various applications (cleaning and cosmetics, medics and nanoscience). The project thus covers the whole innovation chain from basic research to production and application development. To achieve this goal, a complementary consortium of European academic and industrial partners (including a large participation of SMEs) has been formed that covers the whole range of required expertises. In brief, BIOSURFING promotes the use of biotechnology as a valid production process for novel industrial compounds, the development of biotechnological platform technologies and robust microbial industrial production systems. Moreover, the projects helps to realise the objectives of EU environmental and innovation policy initiatives, such as the Environmental Technology Action Plan and the EU Strategy for key enabling technologies.",New-to-nature biosurfactants by metabolic engineering: production and application,FP7,30 September 2015,01 October 2011,2970613.0 BIOTETHED,University of Genoa * Università Degli Studi Di Genova,health,"Biotechnology Ethics is becoming a better-defined discipline in the realm of Bioethics, addressing ethical issues emerging from the application of sciences to biological advances and industrial technology. Ethics must keep abreast of the rapid scientific and technical developments, and this requires continuous research in philosophy and continuous dialogue with ice-breaking scientists. At the same time, the latter realize that only interdisciplinary studies can provide them with the judgement and decision-making capacity necessary for their societal role; therefore their need of BT-Ethics education grows exponentially. Tying research to teaching has been the goal of a strategic action spanning 2003-2005 and producing BT-Ethics courses aimed at PhD students in Europe. Ten of the groups that have driven this progressively successful initiative propose now to expand their activity in several dimensions: a) towards emerging issues from new fields of biotechnological application ? e.g. in nano-neuro-and immunotechnologies, stem cell studies, GM food, human reproductive technologies, b) towards the extension towards new EU member states, c) toward the consolidation and continuity of the educational effort. For b) we rely on the membership of active research groups from Hungary, the Czech Republic and Lithuania; for a) and c) we can count on the partnership of EMBO, whose Science and Society Programme promotes balance discussions on molecular biology via a range of stimulating activities that support public communication from scientists, and target natural disseminators such as teachers. The tools of this action are interdisciplinary encounters with scientists, annual courses located in the Eastern regions of Europe, electronic databases and publications; all activities will engage both the established group leaders and their students to make Biotechnology Ethics an essential element in the toolset needed to enhance the contribution to society well-being.","Biotechnology Ethics: deepening by research, broadening to future applications and new EU members, permeating education to young scientists.",FP6,31 August 2008,01 September 2005,980600.0 BIOTEX,Centre Suisse d'Electronique et de Microtechnique (CSEM) - Recherche et Developpement,health,"Integration of health monitoring tools into textiles brings the benefits of safety and comfort to the users. Instrumented clothes will provide remote monitoring of vitals signs, diagnostics to improve early illness detection and metabolic disorder and benefits to the reduction on medical social costs to the citizen. Ambulatory healthcare, isolated people, convalescent people and patients with chronic diseases are addressed. To date, developments in that field are mainly focused on physiological measurements (body temperature, electro-cardiogram, electromyogram, breath rhythm, etc.) with first applications targeting sport monitoring and prevention of cardiovascular risk. Biochemical measurements on body fluids will be needed to tackle very important health and safety issues. The BIOTEX project aims at developing dedicated biochemical-sensing techniques compatible with integration into textile. This goal represents a complete breakthrough, which allows for the first time the monitoring of body fluids via sensors distributed on a textile substrate and performing biochemical measurements. BIOTEX is addressing the sensing part and its electrical or optical connection to a signal processor. The approach aims at developing sensing patches, adapted to different targeted body fluids and biological species to be monitored, where the textile itself is the sensor. The extension to whole garment and the integration with physiological monitors is part of the roadmap of the consortium. The consortium consists of 8 partners from 4 countries. It includes two research institutes in the field of micro and nanotechnology, two SMEs active in clothing R&D and production, two universities leader in wearable bioengineering, and two companies expert in engineering and manufacturing of textiles for demanding markets.",Bio-sensing textiles to support health management,FP6,31 May 2008,31 August 2005,1900000.0 BIOTIC,Ghent University * Universiteit Gent,health,"The European textile industry, which is in transformation from labour intensive products to knowledge intensive products, has a great demand for innovative high-tech materials with special properties and added functionalities, like smart and biomedical textiles. Today's scientific challenge is to make the enormous potential of biotechnology for production and synthesis of textile materials with advanced functionalities an opportunity for the European industry. The general aim of the research is to functionalise textile materials using modern biotechnology. The research will result in new, specific knowledge and technologies to create biotechnologically modified textile materials with unique properties. The application of functional textile (bio)polymers is typically in the field of medical, safety, care and signalling/detection but also in less obvious application areas such as e.g. tissue engineering and separation technology. Application of biotechnology is not just limited to biological materials; enzymes are able to modify synthetic materials as well. The research will be based on a concerted multi-disciplinary approach, resulting in a drastic increase of knowledge, thereby creating the possibility to produce biotechnologically functionalised materials with unique surface properties and functionalities. The research will focus on enzymatic grafting of functional groups on textile fibres, and specific enzymatic surface modification to obtain functional nano-structured surfaces. Control of enzymatic action at correct time and length scales is a prerequisite to achieve the desired functionalities. Therefore sophisticated technologies and processes will be explored in order to design novel production processes for textiles that exhibit the desired functionalities. The research will build upon expertise available at the department of Textiles at Ghent University and at biotechnological research groups at Ghent University, VIB and other European universities.",Biotechnical functionalization of (bio)polymeric textile surfaces,FP7,31 March 2010,01 April 2008,223288.0 BIOTPHEX,University of Turku * Turun Yliopisto,health,"TThe project aims to develop the two-photon excitation (TPX) method for the measurement of fluorescence from antibody labels on the surface of micro- and nano-sized carrier particles, The proposed two-photon excitation (TPX) method which is based on fluorescence caused in micro-volumes by two-photon excitation combineshe most advanced technology in micro-fluidistics, micro-mechanics, laser scanning microscopy and flow cytometry applications. The method will enable multiplex identification of antibody labels and the project will develop new antibodies suitable for high sensitivity assays. The current microchip laser will be developed to increase pulse frequency and reduce pulse duration. The TPX plate reader will allow multiplexed analysis through the use of fluorescent labelling agents which have different emission wavelengths. The microplate to be used will significantly reduce reagent requirements and dispense with the multiple washing currently required in conventional methods. The project will extend the method to be suitable for cell counting by combining it with oxygen up-take measurement technologies and an appropriate laser model. A fibre laser based on the VIOLA laser will be developed and tested in parallel with the current microchip laser. The objective of the project is to produce pre-production models to allow large-scale screening of a biomaterials and pharmacological compounds which can be carried out in distributed centres, improving the logistics involved in current bio-assays. Significant attention will be paid also to reducing waste and reagent use, The technology to be developed will enable the multinational SME:s involved to created significant products for global markets to be commercialised by the partners through an agreed action plan, taking into consideration the IP-rights developed. The exchange of know-how between the partners will also benefit and support'their own development efforts and provide access to EU funding models for the non-E",Multiplex Bioassays using the Two-Photon Excitation Method (BIOTPHEX),FP6,31 July 2006,01 September 2003,774778.0 BIOTRACHEA,Karolinska Institute * Karolinska Institutet,health,"Age-related cancers, especially of the trachea, are neoplastic lesions that significantly impact upon the lives of thousands of European patients each year. Unfortunately, most present with inoperable lesions for which median survival is less than 12 months. Based on our previous clinically successful experiences with in vivo completely tissue engineered tracheal replacement in benign tracheal diseases, we recently applied this technology in 2 patients with otherwise inoperable primary tracheal cancers. The successful observed outcome confirms the unique opportunity to scale-up an effective therapeutic approach into a widely accessible clinical technology, which could enhance not only the quality of life but even cure otherwise untreatable patients. However, a limitation of our current technology is the time it takes to re-populate the decellularized trachea. This may prove critical in the case of cancer patients. Further, the size of the transplant is currently limited due to the fact that the transplanted tissue needs to be efficiently and rapidly vascularised to prevent necrosis in vivo. To surmount these limitations, we aim to: i) improve our current technique of in vivo tissue engineering human tracheae in a small number of patients and subsequently begin a formal clinical trial, ii) develop pharmacological approaches to activate endogenous stem cells, stimulate tissue regeneration and vascularisation in situ, iii) develop a synthetic tracheal scaffold using a novel nanocomposite polymer as alternatives to natural human scaffolds and iv) develop good medical practice manufacturing process for safe, efficient and cost effective commercial production. This research project is aimed to define a robust airway implantation technique assuring a better outcome for thousands of patients each year. Moreover, we aim to use these results as a starting point to develop clinical approaches that could improve the treatment of age-related cancers of other hollow organs.",Biomaterials for Tracheal Replacement in Age-related Cancer via a Humanly Engineered Airway,FP7,31 March 2017,01 April 2012,3999300.0 BISNES,University of Liverpool,health,"Advanced nanofabrication can produce now nano-structures similar in size with single biomolecules or their self-assembled architectures. Capitalising on this strategic opportunity, BISNES focuses on the design, fabrication and implementation of biomimetic nanostructures which complement biomolecular surfaces and modulate the biomolecular activity. The BISNES project will (i) develop software products for the representation and quantification of bimolecular surfaces, especially those that self-assemble in long-range nano-aggregates, interacting with artificial nanostructures; (ii) design and fabricate nanostructured surfaces and objects that complementary replicate biomolecular surfaces; and (iii) design, fabricate and implement novel hybrid bio-devices which exhibit quantum-leap increase in capabilities (e.g., sensitivity, response time, cost) or entirely new ones. The project will deliver demonstrated technical solutions with impact on a wide range of applications and products: ultra-sensitive bio-diagnostics and drug discovery devices; inherently bactericidal surfaces, medical devices for the in vitro study of amyloid and cytoskeleton proteins central to critical disease (e.g., neurodegenerative diseases, cancer); and hybrid nanodevices that exhibit new electromagnetic properties useful for future IT devices. The research consortium has the critical mass of knowledge and experimental capabilities, as well as the right combination of activities (academia and industry, both SMEs and industry end-user), which allows us to follow the complete innovation path from fundamental science to its implementation in demonstration devices. BISNES' cross-disciplinary approach of will synergise the European first-class position in nanofabrication and biomolecular engineering, through cross-field applications and will contribute to the consolidation of the high added-value of European biomedical, advanced manufacturing and IT industry.",Bio-Inspired Self-assembled Nano-Enabled Surfaces,FP7,31 August 2011,01 September 2008,2876280.0 BLINDPAD,Istituto Italiano di Tecnologia (IIT),information and communications technology,"For visually impaired people it is difficult to digitally get graphical contents increasingly conveyed through sight. The sense of touch can potentially bridge the gap, as it is crucial - in absence of vision - for understanding abstract concepts and acquiring information about the surroundings. Examples are learning at school and developing mental maps in orientation and mobility daily tasks.",Personal Assistive Device for BLIND and visually impaired people,FP7,12 July 2018,01 January 2014,0.0 BLUESHIP,LABOR Srl,energy,"The BLUESHIP project aims to realise an innovative de-NOx Selective Catalytic Reactor (SCR) specifically tailored to the shipping industry, based on electrospun ceramic fibers tailored in designed textures modules. In fact the monolithic design currently in use for SCR imply a very large volume of reaction and heterogeneous reaction yields and rates in the different parts of the reactor. On the other hand, electrospun fibers allow to achieve a dramatic dramatic increase of the exposed active area in the SCR reactor, higher yield of the NH3-NoX reaction and optimization of the fluid-dynamics and gas conversion. This will in turn make it possible to achieve: a reduction of the size and weight of the De-NOx SCR of 50% with respect to state of the art SCR, for installation and retrofit in existing ships and for possible integration into De-Sox units; reduce the consumption, need of purchase and costs of reactant (ammonia or urea) of 20%; reduce the installation costs of 20%; reduce operation and maintenance costs of 15%. The project is promoted by Akretia, who is mother company of the leader in the manufacturing of Exhaust Gas Cleaning Systems for the shipping industry, LINARI, manufacturer of electrospinning equipments and STOGDA, engineering company specialised in naval architecture and design. The possibility to achieve a complete, integrated, light and compact EGCS for DeSOx and DeNOx would represent a milestone in the exhaust treatment for the naval industry and proposers would gain an outstanding market position worldwide, also considering that new technology will allow the shipping industry to comply with the upcoming NOx and SOx limits imposed by the IMO 2016. The potential profits from the BLUESHIP have been estimated to amount to 7,2 M€/y after 3 years from the commercialization, not considering possible application to other sectors (automotive, biomass boilers, and thermoelectric power plants).",Electrospun functionalized nano-materials for ultra-compact de-NOX SCR system in naval shipping,FP7,29 February 2016,01 March 2014,983093.0 BMC,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"Monoclonal antibodies (mAbs) represent a new form of protein-based drug having demonstrated a significant impact on the treatment of several types of cancers. Their specificity towards cell surface receptors makes them able to target and destroy tumor cells. However, a lot of progress is still necessary to understand the mechanism of binding and activity of antibodies in order to improve their targeting capabilities and their efficiency. To reach these objectives, the BMC project proposes to: - Develop a recombinant bispecific mAb with tetrameric binding sites, directed against two different antigens expressed on the same target tumor cell - Develop new bispecific or bifunctional molecules with the property of crosslinking two different receptors on the surface of the cell - Modify the carbohydrate moiety of bispecific antibodies and the tumor targeting of the complement regulator molecule, properdin, to trigger the activation of the complement enzymatic cascade at the tumor site. The recombinant molecules are directed against a selected target antigen for mAb therapy, CDS, as well as a B- cell marker to be selected, in order to treat a specific type of leukaemia, the B-CLL. However, the described innovative cancer immunotherapy strategy will also be extended to the treatment of many other types of cancers especially all carcinomas. The partnership gathers 9 partners recovering the needs of the BMC project: - 7 RTDs specialized in genetic engineering (CNRS), innovative molecules design (UNIL), antibodies vectorisation with nanoparticles (HUJI), CDC activity improvement and cell lines and animal models development (GIENSAT), mechanisms of therapeutic antibodies on patients' cells (OORRBG), toxicology studies and standardization (ITEM), - 2 biotechnology SMEs specialized in therapeutic antibodies development (MAT) and antibodies in-vitro production (MABGENE), - A company dedicated to the project management until month 50: ALMA.",Bispecific Monoclonal Antibody Technology Concept,FP6,30 June 2010,01 November 2005,2450000.0 BME CLEAN SKY 032,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,transport,"The aim of this proposal is to develop hybrid epoxy resin composites, where both the matrix and the carbon fibre reinforcement contains nanoparticles, in order to improve the mechanical, electrical and thermal properties of the carbon fibre reinforced aeronautical structures.","Resin, Laminate and Industrial Nanoparticles Concept and Application. Industrialization",FP7,12 July 2014,10 January 2010,0.0 BMR,University of Plymouth,information and communications technology,"The project explores a superior property in nanoscale magnetic thin film devices - the spin dependent ballistic electronic transport, which is a size-dependent phenomenon that may only occur in nanoscale materials and devices due to quantum mechanics effect. The subject area and the objectives of the project have a close relevance to the NMP priority area 3.4.1.1 for 2003, which calls for long term, ambitious interdisciplinary research addressing, theoretically (incl. modelling) and experimentally, size-dependent phenomena, including quantum and/or mesoscopic scale phenomena. The nanotechnology and nanoscience explored in the project represent a new approach to materials science and engineering, as well as for design of new devices and processes for future data storage, spintronic devices and computers. The consortium consists of European leading experimentalists (P1) in BMR of wire nanocontacts, leading BMR theorists (P5), laboratories with the state-of-the-art nanofabrication techniques (P3) and magnetotransport thin films and devices (P2 and P6), and leading researchers in spin injection and spin transport studies (P4), aiming to integrate the complementary knowledge, infrastructure and expertise for the exploration of the spin dependent ballistic transport properties in thin film nanocontacts. Our overall rrare to employ the state-of-the-art nanofabrication technology for the fabrication of thin film nanoconstrictions with diameter of 50 ~ 5 nm, and to carry out a concerted experimental and theoretical study of the spin transport properties in relation to physical sizes, micromagnetic structures, interfacial and ferromagnetic/semiconductor electrode materials, and polarization in the vicinity of the nanocontacts, aiming to explore high ballistic magnetoresistance (BMR), we will study the magnetoelastic deformations of the contacts that can contribute to the transport process. As well as the contribution by pulsed laser illumination.",Ballistic magnetoresistance in thin film nanocontacts,FP6,31 August 2007,01 March 2004,1749942.0 BNC TUBES,Aalto University * Aalto-yliopisto,manufacturing,"This project aims to develop novel, continuous, chemical vapour deposition (CVD) based synthesis methods for three dimensional regular nanostructures in the form of hetero-atomic nanotubes (NTs) composed of boron, nitrogen and carbon: BN, N-doped carbon, B-doped carbon and mixed B-N-C nanotubes. In doped nanotubes either or both boron and nitrogen atoms replace carbon atoms within the structure and are covalently bound. The main target is to control the electrical properties of nanotubes (i.e. metallic or n- or p-semiconducting), with special attention to control the number of layers: 1 (SWNT), 2 (DWNT) or several (MWNT). The important industrial potential is demonstrated by developing transparent, conductive, flexible nanotube mats. We will explore the optical (i.e. band gap), electrical conductivity, electron field emission as well as non-linear optical properties of produced nanotubes. A significant dedicated modelling aspect is included. We will study NT synthesis using system level computational fluid/aerosol dynamics methods and investigate NT properties based on detailed atomistic modelling using ab initio, molecular dynamics and Monte Carlo simulations. Metrology issues include the development as well as comparison of advanced transmission electron microscopic (TEM) and scanning tunnelling (STM) methods to determine the atomic structure and non-linear optical properties of produced nanotubes. The project team has 9 world-class, multidisciplinary partners in the field, including the Helsinki University of Technology, CNRS, Oxford University, Facultés Universitaires Notre-Dame de la Paix, University of Oulu and Prokhorov General Physics Institute of Russian Academy of Sciences as well as major companies Hewlett-Packard and ARKEMA and an SME, Beneq Oy.","Novel, Heteroatomic Boron, Nitrogen and Carbon Nanotubes (BNC Tubes)",FP6,31 January 2010,01 February 2007,2500000.0 BONEMIM,Bogazici University * Boğaziçi Üniversitesi,health,"Conventional orthopedic implants and dental filling approaches are only partly successful in preventing load-bearing failures and long-term durability, respectively. The problem in the current materials for bone repair and regeneration is that none of them has the hierarchical structure of natural bone that incorporates inorganic crystals with organic molecules. Any long-lasting biomimetic bone-like material should be designed from a well-dispersed inorganic nanoparticle phase in an organic matrix. This work is going to accomplish the following objectives: 1) Development of organic/apatite hybrid biomaterials based on apatite nanoparticles dispersed in a polymer gel. 2) Determination of physicochemical factors affecting the self-assembly of the hybrid material. 3) Characterization of micro- and nano-structure of the hybrid material. 4) Evaluation of mechanical strength and interfacial characteristics of the self-assembled biomaterial. Micro-/nano-structural characterization of this new biohybrid material will be done by using several techniques to investigate material composition and morphology. The mechanical properties of the designed biomaterial will be tested. The outcomes of this research will provide a novel approach for bone regeneration and will serve as a basis for future in-vivo experiments with the long-term goal of repairing bone defects.",A Novel Biomimetic Bone-like Material,FP7,31 July 2014,01 August 2010,100000.0 BONSAI,"National Agency for New Technologies, Energy and Sustainable Economic Development * Agenzia Nazionale per le Nuove tecnologie, l'Energia e lo Sviluppo economico sostenibile (ENEA)",health,"The overall objective is the development of ultrasensitive bio-imaging techniques based on novel multifunctional nanoparticles (NPs) with tailored optical and magnetic properties for visualizing complex cellular structures, receptors, tumor cells and tissues. True innovation rests on the capability to combine the preparation of 'ad-hoc¿ NPs, having different properties and functions, with the development of advanced bio-imaging techniques. The expected improvements of labeling cells and cellular structures with tailored NPs are sensitivity, speed and specificity in the visualization of biological systems. We plan the development of stable colloidal solutions containing non-cyto-toxic, colloidally stable Si-based NPs properly functionalized on the surface in order to improve and tune their optical properties and increase their selectivity in specific biological targets. These NPs will be employed, in cooperation with two SMEs, for the development of optical bio-imaging techniques aiming at: (i) understanding how the genome instructs and orchestrates the functions of cells, organs and organisms; (ii) whole-cell labelling for cell or pathogen detection, cell tracking, cell sorting and cell lineage studies; (iii) optical imaging of tumor cells for early cancer diagnostics. A further task concerns the development of stable colloids of non-toxic, non-immunogenic NPs with: (i) high magnetization, so that NP can be moved in the blood and accumulated in the target organ, (ii) particle size small enough to remain in circulation after injection (iii) narrow size distribution for differential uptake of various tissues. The aim is the development of marketable, well tolerated, highly efficient, specific and economically viable contrast agents for the detection and characterization of complex tumor and/or inflammatory lesions in Magnetic Resonance Imaging, in collaboration with our industrial partner.'",Bio-imaging with Smart Functional Nanoparticles,FP6,30 April 2010,01 November 2006,2909005.0 BOOM,Institute of Communications and Computer Systems,photonics,"BOOM is an integration project that aims to pursue the systematic advancement of Silicon-on-Insulator (SOI) integration technology to develop compact, cost-effective and power efficient silicon photonic components that enable photonic Tb/s capacity systems for current and new generation high speed broadband core networks. BOOM develops fabrication techniques as well as flip-chip bonding and wafer-scale integration methods to fabricate and mount the complete family of III-V components on SOI boards including: arrays of Semiconductor Optical Amplifiers, monolithic blocks of Electro-absorption modulated lasers (EMLs) and highly efficient photodetectors. As such the BOOM SOI optical board technology will be able to blend the cost-effectiveness and integration potential of silicon with the high bandwidth and processing power of III-V material and provide a new generation of functional and miniaturized photonic components including: (a) a single 160 Gb/s SOI Wavelength Converter (WC) and a quadruple array of 160 Gb/s WCs with a record chip throughput of 640 Gb/s on a size 20x5 mm2 , (b) a compact, eight channel, ultra dense WDM InAlAs-InGaAs photoreceiver with record high responsivity and (c) a dual SOI EML transmitter together with its electronic drivers on a single chip. In addition, BOOM invests in the development of improved CMOS compatible waveguide technologies to fabricate miniaturized, low loss and fully reconfigurable wavelength routing cross-connects based on two dimensional grids of serially interconnected micro-ring resonators. BOOM will perform system level integration of all these components to assemble the first prototype rack-mount, ultra-high capacity routing platform based on silicon photonics that will require minimum board space and power consumption and achieve a total throughput of 640 Gb/s. The platform will be evaluated in a network operator test bed employing GbE optical signals.","Terabit-on-chip: micro and nano-scale silicon photonic integrated components and sub-systems enabling Tb/s-capacity, scalable and fully integrated photonic routers",FP7,30 September 2011,01 May 2008,3100000.0 BOOSTQUANTUMCHEM,Kaiserslautern University of Technology * Technische Universität Kaiserslautern,health,"The goal of the proposed IEF project is to develop a novel Density Functional Theory (DFT) method, which will facilitate the very efficient investigation of large macromolecules. DFT is the most used quantum chemical method today, as it allows, at a low computational cost, to perform research at a quantum chemical level on systems containing up to thousands of atoms. However, standard DFT only includes a poor description of dispersion interactions, which occur in systems such as peptides, DNA base-pairs, graphene layers and heterogeneous catalysts. To overcome this great disadvantage the IEF will: a) transform a model for evaluation of dispersion energies at DFT level into a pragmatic and accurate methodology. b) implement the methodology, through design and application of advanced computational chemistry techniques into an efficient and user-friendly software. c) apply this novel DFT method on high-profile problems (nanocatalysts, biomolecules, graphene layers) The results will directly impact research in biochemistry, material science, catalysis and supramolecular chemistry boosting fast and accurate studies on numerous macromolecular systems. The applicant is an expert in DFT, who will complement her skills in Computational Chemistry and design of methods within the Theoretical Chemistry Group at the University of Kaiserslautern (Germany), who are leading scientists in the field. These investigations will allow the fellow to acquire excellent expertise in a pioneering research topic, which is of crucial importance for the worldwide efforts for using macromolecules in innovative technologies. In combination with the complementary training, this IEF project will help the applicant to obtain scientific maturity and actively participate in shaping future research regarding DFT methodologies for large systems, which is a rapidly emerging field. Consequently, the IEF perfectly consolidates the fellow's long-term aim to reach an independent research position in Europe","Boosting the performance of Quantum Chemistry for nanocatalysts, biomolecules and graphene layers by solving the fundamental drawback of van der Waals interactions in Density Functional Theory",FP7,09 November 2014,01 October 2012,174475.0 BOROMAT,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),manufacturing,"This project describes the design and syntheses of new classes of boron-based compounds such as macrocycles, cages, and polymers, made by multicomponent self-assembly through simultaneous condensation of boronic acids with other molecular building blocks. The central goal is the formation of new materials with high porosity and low crystal density. Molecularly defined compounds such as macrocycles and cages can form porous solid state structures upon removal of encapsulated guest molecules (e.g. residual solvent molecules). Similarly, 2- and 3-dimensional polymeric networks may form porous structures if the geometry and the rigidity of the molecular building blocks are correctly chosen. Compared to classical approaches, which involve transition metals, our materials will display rather low densities because we will exclusively use molecules composed of light elements such as B, C, N, and H. This should result in intrinsic advantages for potential applications (e.g. gas storage).",Boronic acids as building blocks for construction of molecular nanostructures and polymeric materials,FP7,01 July 2015,02 January 2011,181970.8 BOTMED,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"The introduction of minimally invasive surgery in the 1980's created a paradigm shift in surgical procedures. Health care is now in a position to make a more dramatic leap by integrating newly developed wireless microrobotic technologies with nanomedicine to perform precisely targeted, localized endoluminal techniques. Devices capable of entering the human body through natural orifices or small incisions to deliver drugs, perform diagnostic procedures, and excise and repair tissue will be used. These new procedures will result in less trauma to the patient and faster recovery times, and will enable new therapies that have not yet been conceived. In order to realize this, many new technologies must be developed and synergistically integrated, and medical therapies for which the technology will prove successful must be aggressively pursued. This proposed project will result in the realization of animal trials in which wireless microrobotic devices will be used to investigate a variety of extremely delicate ophthalmic therapies. The therapies to be pursued include the delivery of tissue plasminogen activator (t-PA) to blocked retinal veins, the peeling of epiretinal membranes from the retina, and the development of diagnostic procedures based on mapping oxygen concentration at the vitreous-retina interface. With successful animal trials, a path to human trials and commercialization will follow. Clearly, many systems in the body have the potential to benefit from the endoluminal technologies that this project considers, including the digestive system, the circulatory system, the urinary system, the central nervous system, the respiratory system, the female reproductive system and even the fetus. Microrobotic retinal therapies will greatly illuminate the potential that the integration of microrobotics and nanomedicine holds for society, and greatly accelerate this trend in Europe.",Microrobotics and Nanomedicine,FP7,31 March 2016,01 April 2011,2498043.0 BOTTOM-UP_SYSCHEM,Ben-Gurion University of the Negev,health,"The study of synthetic molecular networks is of fundamental importance for understanding the organizational principles of biological systems and may well be the key to unraveling the origins of life. In addition, such systems may be useful for parallel synthesis of molecules, implementation of catalysis via multi-step pathways, and as media for various applications in nano-medicine and nano-electronics. We have been involved recently in developing peptide-based replicating networks and revealed their dynamic characteristics. We argue here that the structural information embedded in the polypeptide chains is sufficiently rich to allow the construction of peptide 'Systems Chemistry', namely, to facilitate the use of replicating networks as cell-mimetics, featuring complex dynamic behavior. To bring this novel idea to reality, we plan to take a unique holistic approach by studying such networks both experimentally and via simulations, for elucidating basic-principles and towards applications in adjacent fields, such as molecular electronics. Towards realizing these aims, we will study three separate but inter-related objectives: (i) design and characterization of networks that react and rewire in response to external triggers, such as light, (ii) design of networks that operate via new dynamic rules of product formation that lead to oscillations, and (iii) exploitation of the molecular information gathered from the networks as means to control switching and gating in molecular electronic devices. We believe that achieving the project's objectives will be highly significant for the development of the arising field of Systems Chemistry, and in addition will provide valuable tools for studying related scientific fields, such as systems biology and molecular electronics.","Systems Chemistry from Bottom Up: Switching, Gating and Oscillations in Non Enzymatic Peptide Networks",FP7,30 September 2015,01 October 2010,1500000.0 BRAAVOO,University of Lausanne * Université de Lausanne,health,"BRAAVOO aims to develop innovative solutions for real-time in-situ measurements of high impact and difficult to measure marine pollutants. The concept of BRAAVOO is based on a unique combination of three types of biosensors, which will enable both the detection of a number of specific marine priority pollutants as well as of general biological effects that can be used for early warning. First, innovative bimodal evanescent waveguide nanoimmuno-sensors will enable label-free antibody-based detection of organohalogens, antibiotics, or algal toxins. Secondly, bacterial bioreporters producing autofluorescent proteins in response to chemical exposure will enable direct detection of alkanes or PAHs from oil, heavy metals, or antibiotics, and can further assess the general toxicity of the water sample. Finally, the photosystem activity of marine algae is exploited to monitor changes induced by toxic compounds. BRAAVOO will construct and rigorously test the three biosensor systems for their analytical performance to the targeted pollutants. To enable low-cost real-time measurements, the three biosensors will be miniaturized, multiplexed and integrated into innovative modules, which allow simultaneous multianalyte detection. The modules will include all optical elements for biosensor signal generation and readout, the microelectronics for data storage, and specific microfluidics to embed the biosensors or cells, and expose them to aqueous samples from dedicated autosamplers. The modules can be used either as stand-alone instruments for specific marine applications or can operate autonomously and in real-time in an integrated form. Hereto, they will be embedded in a marine buoy and an unmanned surveying vessel. Vessels and stand-alone biosensor modules will be tested extensively and in comparative fashion on real marine samples and in mesocosms. If successful, the flexible and innovative BRAAVOO solutions will democratize and revolutionize marine environmental monitoring.","Biosensors, Reporters and Algal Autonomous Vessels for Ocean Operation",FP7,30 November 2016,01 December 2013,3529127.0 BRAIN STED,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Synapses are small, highly specialized structures of intercellular contact that play a crucial role in neuronal information processing and memory. While traditional fluorescence microscopy is an extremely powerful tool to study the dynamics of biological processes in vivo with molecular specificity, it has insufficient resolving power to dissect details of synaptic structure and functional organization or the structure of small subcellular components. In contrast, far-field optical super-resolution techniques provide spatial resolution at the nanoscale beyond the limit imposed by the diffraction of light. However, current super-resolution techniques are limited to thin brain preparations or to the surface of thick samples. The central aim of this proposal is to establish optical super-resolution methods for imaging chemical synapses in all layers of the cerebral cortex and in deep lying structures of the brain and to apply these techniques to timely questions in neurobiology. We will develop intravital super-resolution microendoscopy based on the stimulated emission depletion (STED) technique. This will enable intravital microscopy of arbitrary brain regions with diffraction-unlimited resolving power. In addition, we will miniaturize the setup, opening up the investigation of nanoscale structures in the brain of awake, freely moving and behaving animals. With this, we will be able to correlate for the first time synaptic structural or organizational plasticity at the nanoscale with behavioural stimuli in a living animal, including for instance in the hippocampus of an animal exposed to a learning situation. Furthermore, these methods will advance the understanding of the interplay between neurons and glia, in particular at synapses, and will help to shed light on brain structure and function in physiological states as well as in disease.",Intravital optical super-resolution imaging in the brain,FP7,31 May 2014,01 June 2012,167390.0 BREAD-GUARD,Fundación Tecnalia Research & Innovation,health,"Quality assurance plays a key role in the food industry. Current control of safety and quality characteristics in the bakery industry is carried out mainly by random sampling of the initial, intermediate and/or final products. However, this methodology does not allow immediate adjustments to the production process in case any negative quality features are detected and consequently large batches of non-conforming products often need to be disposed and a lot of resources (energy, water, ingredients) are wasted. Therefore this project aims to develop an innovative and affordable quality and performance control system for baking processes based on nanospectrometry and ultrasound, allowing for continuous quality measurement and process adjustment. The complete Bread-Guard system consists of two sensors and a corresponding soft-/hardware package which in combination can measure the key parameters of the baking process and adjust it to the optimal set-up. The first sensor is based on nano-spectrometry (Fabry-Pérot principle) and will be used to measure parameters in the ambient air of the oven (e.g. humidity, temperature) as well as product surface characteristics (e.g. degree of browning). The second sensor based on ultrasound will measure structural and mechanical properties within the products (e.g. density, porosity, mechanical strength). The sensor-data will be used to adjust the baking process (temperature, humidity) in real-time through a feedback loop. An applied research approach involving Europe's leading research institutes in the field of baking, sensor development and process control, equipment producers for sensor, oven, and software development as well as several SME bakeries will not only ensure the compatibility of the new system with current technologies, but also raise the acceptance of the baking sector. Nevertheless, it is foreseen, that the to-be-developed technology in future can be adapted to other sectors in the food industry.","Development of a cost-efficient, precise and miniaturized sensor system for quality and performance control in baking processes",FP7,30 November 2016,01 December 2013,2740426.0 BRIDGE450,ASM International NV,information and communications technology,"Five major global semiconductor companies are working in the G450C consortium based in Albany N.Y. to introduce 450mm wafer semiconductor processing and are now installing the first wave of 450mm prototype systems. Intel and TSMC lead this effort with published roadmaps showing pilot lines in 2016, production in 2018. Samsung will soon follow which will force GlobalFoundries, SK Hynix, Toshiba, UMC and Micron to invest in 450mm else face a steady decline.The 2012 AENEAS/Catrene paper “Innovation for the future of Europe: Nanoelectronics beyond 2020” emphasized the importance of the 450mm transition for the European Equipment & Materials (E&M) companies. Most of these companies decided that to secure their global markets they would take an active part in 450mm development and participated in cooperative 450mm projects. The ENIAC project EEMI450 is complete and projects in CATRENE (SOI450 & NGC450) and ENIAC (EEM450PR & E450EDL) are proceeding, the latter two targeting a 450mm pilot line at imec. Further projects are planned and Europe can feel proud its E&M companies are striving for leadership in each of their fields.The ENIAC Coordination Action Enable450 began in 2012 to assist European 450mm programmes with data collection, standards, G450C liaison, dissemination of 450mm topics and other activities. The Bridge450 Support Action seeks to run in parallel with Enable450 to expand its scope with more focus on Asian semiconductor manufacture. Bridge450 will support the European E&M companies and specially the SMEs to become aware of and understand Asian technical requirements and to develop solutions to address this market. To assist the information flow, a Semiconductor Board will include Samsung and TSMC.A second objective of Bridge450 will be to establish the possibilities of 450mm semi-manufacturing in Europe and what would be needed to facilitate such an operation, which will be vital for the future of advanced nano-electronics in Europe.","Support Action for 450mm topics establishing a Bridge between European EM entities and IDMs, Foundries and Entities Worldwide",FP7,10 July 2017,11 January 2013,495999.0 BRIGHTEMIL,Ruhr University Bochum * Ruhr-Universität Bochum,energy,"The idea which should be taken to the proof of concept is the application of nano energy-conversion phosphors in ionic liquids. The energy efficiency and performance of photonic devices such as CFLs (compact fluorescent lamps), LEDs (light emitting diodes) and SCs (solar cells) will be improved by more efficient use of light. For this, special nano energy-conversion phosphors (ecPs) will be coated on the respective device by a new technique relying . As no new development of the devices themselves is required, the invention has a near-market potential. The new technology will allow for a better device performance, higher energy efficiency, safer and greener production, diminish the impacts on health and environment during manufacturing as well as end-of-life. The consumption of rare materials where world-market shortage is observed will be reduced and the economic position of European companies improved.",BrightEMIL : EMIL goes green - Exceptional Materials from Ionic Liquids for Energy Saving Applications in Photonics,FP7,28 February 2013,01 March 2012,149610.0 BRIMEE,D'Appolonia SpA,construction,"The challenge of today lies in the accomplishment of sustainable and low-energy buildings, which can combine at the same time the thermal insulation properties with healthy, comfortable, accessible and safe indoor environment. Reduction of the energy demand through the use of insulating materials still remains a challenge for European architects and building designers as well as materials producers. Beside good and consistent thermal and acoustic performance overtime, a good and marketable insulation material should in fact be self-extinguishing, not degradable, unshrinkable or non-settling, safe during handling and installation, low cost and should not pollute the indoor building environment, while having a low embodied energy, proven through LCA assessment. The main aim of the BRIMEE project is therefore to combine the development of better performing insulation materials for improving buildings energy performance and having as final overall objective a significant reduction of buildings operational energy, in combination with the capability not to emit harmful substances and to act as an absorber for indoor pollutants. Our innovation is based on a Nano-Cristalline Cellulose (NCC) based foam, strengthened with Natural derived resin (furan), providing self extinguishing features. An enzimatic approach and protein fusion to the Cellulose basis is exploited to confer to the material additional functionalities from the bulk, such as fragrance release, water repellence or anti-bacteria. Thanks to an advanced processing, the NCC material can be profitably extracted from the waste streams of the pulp and paper industry. Although the BRIMEE product family is applicable for the envelope and interior partitions of both new and existing buildings, most of the impact and the largest market is represented by buildings built before 1975 and requiring retrofitting. This is the initial market to be penetrated in line with EU priorities and recent action plans and directives.",Cost-effective and sustainable Bio-Renewable Indoor Materials with high potential for customisation and creative design in Energy Efficient buildings,FP7,06 June 2019,07 January 2013,4000000.0 BSICS,Technion Israel Institute of Technology,photonics,"The objective of this proposal is to devise new ways of shaping light and other electromagnetic waves in complex and novel structures. The research will delve into fundamental aspects of electrodynamics, from classical optics to the quantum mechanical dynamics of photons. Over the past twenty years, several new kinds of artificial media for electromagnetic waves were demonstrated, among them photonic crystals, metamaterials, plasmonic materials, and more recently graphene-like photonic lattices. These new kinds of 'electromagnetic media' call for new methods for beam shaping to facilitate control over the electromagnetic fields propagating within them. Moreover, many novel photonic systems and devices rely on strong coupling between light and matter. Naturally, such systems combine quantum mechanics effects with classical electrodynamics. For example, modern experimental research would greatly benefit from efficient coupling of light to quantum dots, nano-photonic structures embedded in silicon chips, or particular molecules -to manipulate and probe the molecular dynamics. All of these necessitate novel methods for shaping light in new kinds of structures, which cannot be addressed by traditional techniques. In this research plan, I aspire to make fundamental theoretical contributions that, apart from their basic research component, will also contribute to a large variety of present and future applications. I believe this ambitious research will have high impact, advancing the knowledge on waves' propagation in structured media, which is at the forefront of current research. The outgoing phase (first two years) will take place at Stanford, under the supervision of Prof. Shanhui Fan. The return phase (third year) will take place at the Technion, under the supervision of Prof. Gadi Eisenstein. The return department (the Faculty of Electrical Engineering) is highly supportive of my application: the support letter of the Dean is incorporated in the proposal (in B3).",Beam Shaping in Complex Systems,FP7,30 June 2017,01 July 2014,253947.0 BUGWORKERS,AIMPLAS - Plastics Technology Centre * Asociación de Investigación de Materiales Plásticos y Conexas,health,"The project aims to develop a new cost-competitive and environmentally friendly bionanocomposite material based on the combination of a polyhydroxybutyrate (PHB) matrix with new chemical, structure produced by new fermentation culture technology with two types of nanofibres,cellulose whiskers and lignin-based, in order to have a true alternative to engineering materials in two main sectors: household appliances, computers & telecommunications. To fulfil this global objective, current limitations of PHB polymers and their composites will be overcome using a synergic combination of different approaches: •A tailor-made PHB biopolymer structure obtained using new fermentation culture conditions, i.e, by synergic combination of different media and precursor feedings (specific sugar blends) obtained from hydrolyzed bio-mass, being able to select a structure to provide a PHB with enhanced functionalities (improved thermal and chemical properties, cellulose compatibility, processing, higher impact,..) in comparison with commercial ones. •To improve the cost competitiveness of PHB biopolymer by optimization of the fermentation process (increasing yield) and the use of lingo-cellulose biomass and other industrial by-products as fermentation feedstock. It will be no competition with food supply. •Development of cellulose whiskers and lignin nanofibres using enzymatic production routes with new functionalities (antimicrobial, flame retardant and self-assembly) from wood waste. •Compounding of new PHB with a synergic combination of both types of nanofibres and long natural fibres, using the planetary multi-screw extruder for improved nanofibres distribution, reducing thermal degradation,improve matrix-nanofibre interphase and introduction of coupling agents by reactive extrusion. •Development of multilayer structures (co-extrusion and co-injection) in order to obtain multifunctional material properties to improve the final performance of plastic parts in select sectors.",New tailor-made PHB-based nanocomposites for high performance applications produced from environmentally friendly production routes,FP7,30 June 2014,01 July 2010,3400430.0 BULCANATU,King Juan Carlos University * Universidad Rey Juan Carlos,transport,,Developement of CNT doped reinforced aircraft composite parts and a,FP7,11 June 2016,08 January 2013,0.0 BUNSMAT,Ozyegin University * Özyeğin Üniversitesi,transport,Bulk ultra-fine grained (UFG) and nanostructured (NS) materials have attracted immense interest in recent years due to the paramount goal of achieving simultaneous increase in strength and ductility. A unique method for obtaining these materials is the utilization of severe plastic deformation for structural refinement. Despite their technological importance in industries ranging from automotive and aerospace to energy and biomedical; efforts on difficult-to-work hexagonal close packed (hcp) materials have been comparably limited in quantity and scope.,Microstructural Design of Bulk Ultra-fine Grained and Nanostructured Materials for High Performance Applications,FP7,05 May 2017,05 June 2013,0.0 BUONAPART-E,University of Duisburg-Essen * Universität Duisburg-Essen,environment,"The BUONAPART-E project aims to demonstrate that a physical nanoparticle synthesis process can be economically scaled-up to yield 100 kg/day production rate, which is the target rate mentioned in the Call Topic. The process is simple, versatile, and reliable. It avoids chemical precursors and solvents, while fully recycling the necessary inert carrier gas, resulting in a minimal impact on the environment. The process does not necessitate external heating of the inert gas, thereby keeping energy consumption low.",Better Upscaling and Optimization of Nanoparticle and Nanostructure Production by Means of Electrical Discharges,FP7,01 July 2018,02 January 2012,0.0 BY-NANOERA,Belarusian State University,health,"The project aims at reinforcing RTD and cooperation capacities of the Institute for Nuclear Problems of Belarusian State University in the area of applied nanoelectromagnetics. This new research discipline comprising the classical electrodynamics of microwaves and present-day concepts of condensed matter physics is covered by the FP7 Theme 4 'Nanosciences, Nanotechnologies, Materials and new Production Technologies -NMP'. INP BSU is the founder and leading research center in Belarus in this area. Within the project a set of complementary networking and training activities is foreseen with a strong involvement of already existing and new partners from EU member states and associated countries. Besides, based on research results and their applications in material sciences and medicine, and also taking in consideration the emerging socio-economic needs in Belarus and EU, a strategy of the INP BSU further development will be proposed. All together, the activities will support national RTD in applied nanoelectromagnetics, contribute to young researchers' career development, intensify information and experience exchange between Belarus and EU teams thus contributing to creation of the European research network in applied nanoelectromagnetics, as far as increase visibility of INP BSU in the European Research Area and its participation in the FP7. Also, the strategy developed for INP BSU will be proposed and disseminated as a model for the integration of the other Belarus teams into European Research Area.",Institutional Development of Applied Nanoelectromagnetics: Belarus in ERA Widening,FP7,31 October 2013,01 November 2010,380811.0 C3ENV,Jacobs University Bremen gGmbH,energy,"Combinatorial Computational Chemistry is developed as a standard tool to tackle complex problems in chemistry and materials science. The method employs a series of state-of-the-art methods, ranging from empirical molecular mechanics to first principles calculations, as well as of mathematical (graph theoretical and combinatorial) methods. The process is similar as in experimental combinatorial chemistry: First, a large set of candidate structures is generated which is complete in the sense that the best possible structure for a particular purpose must be found among the set. This structure is then identified using computational chemistry. We will apply methodologies at different stages in hierarchical order and successively screen the set of candidate structures. Screening criteria are based on the computer simulations and include geometry, stability and properties of the candidate structures. Detailed characteristics of the final materials will be simulated, including the X-ray diffraction pattern, the electronic structure, and the target properties. We will apply C3 to two important problems of environmental science. (i) We will optimise nanoporous materials to act as molecular sieves to separate water from ethanol, an important task for the production of biofuels. Here, materials are optimised to transport ethanol, but not water (or vice versa). The tuning parameters are the channel size of the material and its polarity. (ii) We will optimise nanoporous materials to transport protons, an important task for the design of energy-efficient fuel cells, by distributing flexible functional groups, acting as hopping sites for the protons, in the framework.",Combinatorial Computational Chemistry A new field to tackle environmental problems,FP7,31 January 2016,01 February 2011,1500000.0 C4R,Comune di Genova,environment,"It’s now very clear how much Genoa and Liguria need to reinforce the researchers role, especially after the 2010 Researchers Night edition. The C4R consortium worked hardly to guarantee the researchers engagement in the three cities events. On that occasion they will meet citizens also for introducing themselves and speak about their private and professional life. Researchers in Liguria are numerous and have an key scientific role in a European and Mediterranean perspective, and, thanks to their common past experiences, the network is now able to involve a high number of researchers from the excellence centres in Liguria (IIT, CNR, UNIGE, ENEA, INGV, etc) which are engaged in different scientific fields: nanotechnology, environmental engineering, robotics, healthcare and biomedical, software, electronic hardware, technological engineering, marine engineering, environmental sustainability and ecology. This Night will present a higher number and a great variety of events: researchers will organize lab areas, “adventures” and special tours, welcoming occasions, theatre, music, performing and visual art, workshops, talks and happy hours, ice-creams breaks, puzzles, scientific dinners, cinema, awards and interviews. These activities will take place on the public transport (boats and buses), along the rivers, in gardens and parks, in museums, palaces and central squares. All the locations chosen are very close or have huge indoor spaces available for hosting all the events planned during the Night. In this way we intend to prevent from the risk of a limited participation caused by bad weather conditions as happened in the 2010 edition. Palazzo Ducale in Genoa represents the widest and fascinating indoor space of the whole region being also very close to the main streets of the old town where movida takes place especially during weekends. Here and in Palazzo Scotto Niccolari in Albenga and in the Fortress in Sarzana events will take place and go on till late at night.",CRAZY FOR ROCKING RESEARCHERS,FP7,11 June 2014,05 January 2012,42910.5 CACOMEL,Technical University of Berlin * Technische Universität Berlin,photonics,"A strong expansion of the frequency range towards terahertz and infrared is the major trend in the modern electronics and optoelectronics. It relies on the incorporation of modern nanotechnology that has already given the birth to nanoelectronics, a rapidly developing discipline focused on both the dramatic increase of the component integration level and decrease in a power consumption. Performance of nanoelectronic devices is strongly influenced by quantum effects that often even determine properties of nano-sized components. The project aims at understanding of fundamentals of the electromagnetic processes in nanocircuits, theoretical and experimental investigation of underlying mechanisms responsible for their fascinating properties, and development of physical basis for use of these properties in novel nanoelectronic devices. The project focuses on linear and nonlinear electromagnetic effects in nano-carbon structures, such as onion-like carbon and both single- and multi-wall carbon nanotubes. We will investigate in detail a performance of nanocircuits based on carbon nanotubes and other nanocarbon materials. The multidisciplinary and challenging project relies on the complementary expertise of the consortium teams and is based on the original approach combining electrodynamics of mesoscopic inhomogeneous media and quantum theory of electronic ensembles with reduced dimensionality.",Nano-carbon based components and materials for high frequency electronics,FP7,30 November 2014,01 December 2010,153000.0 CAFFEIN,University of Copenhagen * Københavns Universitet,health,"Aim of the CAFFEIN network is to provide 10 early stage researchers (ESRs) and 2 exprerienced researchers (ERs) with excellent training in an industry relevant area of cancer research, complementary skills required for pharmaceutical industry, and knowledge in setting up biomedical start-up companies. To this end, the network comprises two full industrial partners: the established pharmaceutical company Medimmune, a global leader in immunopharmaceuticals, and the small biotech company Gimmune, which used breakthrough results in nanotechnology to establish a new enterprise. The research focus of CAFFEIN, which stands for Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion, is to understand the mechanisms, how fibroblastoid cells support tumor progression and metastasis formation. CAF biology is therefore rather complex, but the research groups of the CAFFEIN network cover many different aspects of it, thus having a critical mass to provide relevant training in this area. Training in complementary skills important for work in the pharmaceutical industry is provided by the industrial partner MedImmune, where communication with management, industrial project planning, IPR, etc. will be taught. Entrepreneurial skills, business plans, funding by venture capitalists, and patentability of research findings are highlights of the training provided by the industrial partner Gimmune. All this training is transmitted to the ESRs/ERs by networkwide events, secondments and tight research collaboration. Taken together, the CAFFEIN research training network combines the acquisition of excellent scientific knowledge in an area highly attractive for pharmaceutical industry with special education in relevant complementary skills that increase employment chances of the trained researchers in industry and that encourage them to translate their scientific results into products, thus improving health and economic welfare of European citizens.",Cancer Associated Fibroblasts (CAF) Function in Tumor Expansion and Invasion,FP7,30 September 2016,01 October 2012,3312522.0 CAJAL4EU,NXP Semiconductors Belgium NV,health,"The main objective of the ENIAC JU project CAJAL4EU is to develop miniaturised biosensor technology platforms enabling diagnostic test manufacturers to build multi-parameter in-vitro test applications rapidly in a robust, user-friendly and cost-effective way. They will involve nanoelectronic-based transducers with chemical sensing capabilities providing the interface with the clinical samples. In contrast to other biosensor technologies, these devices will be capable of integration with low-cost CMOS nanoelectronics. The cost of a nanoelectronic biosensor can be ultra low at high volumes.",Chip Architectures by Joint Associated Labs for European Diagnostics,FP7,01 February 2013,01 March 2010,3664351.0 CALM TRACKS AND ROUT,CALMA-TEC Lärmschutzsysteme GmbH,construction,"The European Parlament and Council has established new standards of tolerance versus traffic noise: reduction of dB(A) to current standards. To meet these improved environmental standards, more effective noise barriers are requested, better noise abatement technologies, new absorptive materials and higher sound screens, eventually tunnels will be necessary.Noise harassment is widely the cause of mental depression and physical exhaustion of people. It is one of the biggest challenge of human sanity in towns and country. Our project is dealing with noise protection walls with improved noise shielding abilities through special shaping and new absorptive qualities of material and construction.Objectives:To ACHIEVE ESSENTIAL IMPROVEMENTS OF THE SHIELDING PERFORMANCE, ACOUSTIC QUALITY AND PSYCHO-ACOUSTIC PERFORMANCE AND INNOVATIVE DESIGN OF NOISE BARRIERS are objectives of this project. Building up on the so far reached innovation and improved effect, we want to:- Focus on further development of innovative designs, constructions, materials and effects increasing the shielding efficiency of noise barriers.- Study acoustic phenomena of, and inside sound barriers in theory and practical application.- Scientific evidence of the refraction edge performance of different shapes, materials and dimensions: extinction and/or modulation of noise by interference.- Search and evaluate new materials and surfaces (introducing nanotechnology) in their absorbtive or interference behaviour.- Create and evaluate new designs: optical appearance and attractive design- Psycho-acoustic performance: less and friendly noise sensation.- Rigid function within overall road and track design; heavy duty, high durability, climatic resistance, shock resistance and crash performance.",INNOVATION OF NOISE BARRIERS: IMPROVED NOISE ABATEMENT FOR MOTORWAYS AND RAILWAY TRACKS,FP6,19 August 2007,20 April 2005,1004014.8 CAMBAR07,University of Cambridge,energy,"The target of the present project is to fabricate high efficiency nanostructured hybrid solar cells in which the exciton recombination is strongly avoided by interface nanoengineering. The cells will be made in three main steps. First, large-area, ordered Anodised Aluminium Oxide (AAO) templates will be fabricated electrochemically onto transparent conducting substrates. Order will be induced prior to the anodization of aluminium by pre-patternig using Focussed Ion Beam (FIB). In a second step, the ordered templates fabricated will be used for the synthesis of large-area arrays of aligned semiconducting oxide nanowires. The arrays will be synthesized by electrodeposition within the template pores and by later removal of the same. Finally, films of conducting organic materials will be deposited onto the nanowire arrays by classical methods such as spin-coating from solution or thermal evaporation. The structures and devices obtained after each of the steps will be thoroughly characterised and the final test device performance will be evaluated. There are many materials science issues which will be addressed for improving the efficiency of hybrid solar cells. In particular, reduction of recombination of photo-induced charges through control of arrangement and size of oxide nanostructured electrodes, understanding of charge transfer at inorganic/organic interface, and permeation of organic semiconductor into the oxide nanostructures.",Large-area ordered arrays of semiconducting oxide nanowires as electrodes for nanostructured hybrid solar cells.,FP7,30 September 2010,01 October 2008,169390.0 CAMGRAPH,University of Oxford,information and communications technology,"Graphene is now a leader among new super-materials poised to transform the electronics and nanotechnology landscape. Specifically, graphene nanoribbons are purported to enable a host of applications such as superfast electronics. However, problems associated with large scale growth and patterning of graphene akin to silicon components constitute one of the main obstacles to using this material in device applications. I address this challenge by proposing a disruptive and novel method to produce graphene nanoribbons directly on arbitrary substrates via a unique probe-based nanomanufacturing approach that combines nanoscale catalysis and nanomechanical exfoliation for a scalable, manufacturable process. This would be a very significant enabler for large scale manufacturing of high performance graphene devices, as this would allow us not only to make standard graphene devices, but also allow one to rework or repair existing chips, create wearable electronics and pattern on arbitrary substrates such as plastics. This work will be carried out in a high-impact group with unique yet complementary expertise.",Catalysis driven Manufacture and patterning of Graphene at the nanoscale using probe technologies.,FP7,04 June 2017,05 January 2013,221606.4 CAMINEMS,Curie Institute * Institut Curie,health,"The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS's new approach will involve a new generation of bio-functionalised multifunctional magnetic nano and microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or 'micrometastases' and the molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation and a research-intensive SME for exploitation.",Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells,FP7,31 December 2012,01 July 2009,3551143.0 CAMIR,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Miniaturization of catalytic processes is a major challenge for and quot;individual and quot; treatments in the fields of transportation, of energy management, of medical care, or of house equipment. A hard point to overcome in these applications is the fabrication of microreactors with maximum ratio of catalytic efficiency over the reactor volume. The project aims in fabricating such catalytic microreactors composed of a metallic preform containing microchannels with a diameter in the order of 50 microns, whose surface will be entirely and efficiently coated by a complex catalytic film.This complex coating will be composed of metallic catalytic nanoparticles such as platinum ones, dispersed on a high specific area ceramic film such as gamma alumina. It will be fabricated by a two sequential steps chemical vapour deposition/infiltration (CVD/CVI) process. CVD is well adapted for eficient infiltration in porous media and for the deposition of coatings with particular microstructure. Metalorganic precursors will be used in appropriate operating conditions to allow for a process with low thermal budget, compatible with the geometric and physical characteristics of the material of the perform (eg. aluminium).The micrireactors will be tested on a test bench following two model reactions of high industrial interest: (i) oxidation of carbon monoxide, (ii) total oxidation of propane.The porous metallic preform is commercialized by a French SME which is actually in contact with international industries for the fabrication of massive and supported catalytic systems. The project is expected to allow this SME to become, in fine, one among the world leaders on innovative technological solutions in the domain of catalysis with, consequently an important increase in terms of activity and employment.",Catalytic microreactors for launched systems,FP6,31 October 2006,01 November 2004,150804.0 CAMLC10,University of Cambridge,health,"The target of the present project is to fabricate large loading capacity, stimuli-responsive drug delivery nanodevices (DDNDs) with potential application in anticancer therapy. The proposed theme is central to People Programme for Career Development framed under FP7 within a research area which is truly at the cutting-edge and which is strongly interdisciplinary (materials, chemistry and nanoengineering). The proposed work falls directly under 'The European Strategy for Nanotechnology and the Nanotechnology plan'. In particular, there are two themes under this Action Plan addressed by this proposal, e.g. Health and NMP (Nanosciences, nanotechnologies, materials and new production technologies). The proposal involves both materials preparation and drug loading/releasing processes. The DDNDs will be made in three steps. Firstly, magnetic Fe3O4 nanoparticles (NPs) are prepared. Then a decomposable FeOOH shell will be coated on the NPs. Finally, the above core-shell structures will again be coated by a layer of mesoporous silica forming core-double shell structure. The DDNDs with increased hollow volume will be obtained by the decomposition of the FeOOH inner shell. Thereafter, the drug loading and releasing will be done in two separated steps where the release can be triggered by a stimulus input, e.g. sharp pH change. All structures/devices obtained from these steps will be thoroughly characterised. The evaluation on the delivery efficiency and improvement on the fabrication process parameters will be made according to the characterisation results. In particular, the 'zero-release' before the stimuli input, the load maximization per DDND and the sustainability of the release once triggered will be the main aims to be achieved in the project. As fulfilled, all pre-set training objectives will be realised by the knowledge and competencies gained in the project and will definitely benefit to the candidate career development and mobility among the European Research Area.","Fabrication of Large Loading Capacity, Stimuli-Responsive and Release-Controlled Drug Delivery Nanodevices",FP7,30 June 2013,01 July 2011,209092.0 CANA,University of Cambridge,energy,"CANA explores new methods for the fabrication of complex carbon nanomaterials such as carbon nanotubes (CNT) and graphene. The project emphasizes the importance of the hierarchical organization of materials over several lengthscale. To achieve this, CANA follows a methodical approach, that systematically optimizes mesoscale chemistry, nanoscale morphology, microscale porosity and macroscale assembly and packaging. For instance, we will pursue combined top-down microfabrication and bottom-up self-assembly, accompanied with surface modification through hydrothermal processing. While the properties of organized carbon nanomaterial assemblies can be tuned towards a wide variety of applications, this project specifically focusses electrodes for energy storage. This project is highly multi-disciplinary as it brings together expertise ranging from macro- and microscale manufacturing, to nanoscale material synthesis and mesoscale chemical surface modification and electrochemistry. The funding provided through this CIG grant will mainly be invested in vital pieces of equipment to enable pursuing the above objectives, but also for travel in Europe and for setting up new research collaborations. As such, this project is crucial for the applicant's integration in his new research position. Beyond this initial project, the expertise and equipment acquired through this grant will be employed for the development of new water filtration techniques.",Carbon Nanomaterials Assembly,FP7,31 August 2017,01 September 2013,100000.0 CANADEVICE,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"Straightforward downscaling of the basic components of the electronics industry according to Moore's law will reach its end within the next 10-15 years. To continue towards the nanoscale, complex technological barriers will have to be overcome and eventually further downscaling will be prevented due to physical limitations associated with the small dimensions. This prospect stimulates research in new materials, in nanotechnology-based concepts and in the development of a disruptive technology.High-potential candidates for incorporation in the post CMOS nanoelectronics devices are carbon nanotubes (CNT) and nanowires. It is the goals of CANADEVICE to address the needs of future nanoelectronics by the design and development of a relevant device based on CNTs or nanowires. Contrary to the major part of the ongoing research, which focuses on improving the quality of the CNTs and nanowires themselves, we want to advance the research field by providing a useful device. It is our goal to develop a product which can be mass-fabricated.To achieve this goal, CANADEVICE will adopt a multidisciplinary approach based on (i) a study of existing and novel device architectures in order to select a promising device, (ii) simulation tools, processing facilities and characterization tools to develop a prototype of the device of our choice, and (iii) the implementation and testing of the device.The outcome of the project will have a large impact on the nanoelectronics field as it will assess whether CNT- and nanowire-based device technologies can form the disruptive industry. This high-quality project offers a valuable opportunity for the applicant to reintegrate in her home country. She will be able to give a unique contribution to the project through a combination of her electrical engineering background and the expertise she acquired in the third country on non-classical devices and associated experimental techniques.'",Development of IC devices based on carbon nanotubes and nanowires,FP6,30 September 2007,01 October 2005,80000.0 CANAPE,University of Cambridge,information and communications technology,"A major limitation on the application of the unique properties of carbon nanotubes has been their high cost and lack of availability. This IP brings together leading laboratories and companies within Europe to produce nanotubes on a bulk scale of ultimately tons per year. The large scale growth of carbon nanotubes will be developed by chemical vapour deposition (CVD). The applications in electronics as interconnects and vias for integrated circuits, for field effect transistors, and spin coherent transport will be developed. Field emission will be developed further for use in microwave amplifiers and micron scale x-ray sources. Electronic applications will be enabled by controlled growth in plasma enhanced CVD and thermal CVD. Multi-wall CNTs will be used as a catalyst in large scale chemical reactions such as the dehydrogenation of ethyl benzene to styrene. Control of the nanotube internal orientation to give the herring bone microstructure is needed for catalysis, as plane edges are catalytically active. Functionalization of CNTs will be extended, in order to improve the performance of structural, electrically conducting and thermally conducting nanotube- polymer composites. Dispersion of nanotubes at high loading will be achieved in polymers to obtain high strength composites. Nanotubes are known to act as high energy density actuators, or 'artificial muscles'. Nanobiological devices will be fabricated based on self-assembly and molecular absorption. A toxicological study of CNTs particularly with respect to possible health hazards will be carried out, and nanotube/polymer composites will be tested for biocompatibility. Public acceptance of nanomaterials and nanotechnology will be encouraged by publicity and poling. Training, workshops and conferences will be held, and to promote technology transfer from universities and research institutes to companies. SMEs will be dominant in the CVD, catalysis and composite applications","Carbon Nanotubes for Applications in Electronics, Catalysis, Composites and Nano-Biology",FP6,31 May 2008,01 June 2004,6400000.0 CANCER NANOMEDICINE,University of Cyprus,health,"Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat solid tumors, it does not enable uniform delivery of these particles to all regions of tumors in sufficient quantities. This heterogeneous distribution of therapeutics is a result of physiological barriers presented by the abnormal tumor vasculature and interstitial matrix. These barriers are in large part responsible for the modest survival benefit offered in many cases by clinically approved nanotherapeutics and must be overcome to realize the promise of nanomedicine in patients. More specifically, we need to determine the design criteria - the size, charge and configuration of various nanoparticle platforms - that optimize drug delivery to tumors. Here, I propose the development of a mathematical framework for the delivery of therapeutic nanoparticles to solid tumors. The model will account directly for the properties of the tumor micro-environment as well as for the properties (size, charge and configuration) of nanoparticles to predict their intratumoral distribution. I will specify the model to a human sarcoma and a human mammary carcinoma cell line for which a complete set of experimental data that characterize their micro-environment exists. Informed by these experimental measurements, I will use the mathematical model to construct 'design maps' that will predict the nanoparticle properties that optimize intratumoral delivery, and thus the efficacy of cancer therapy. I will also employ the model to investigate if modifications in the tumor micro-environment with the use of anti-angiogenic and anti-fibrotic agents can improve the distribution of nanomedicine to solid tumors.",Optimizing the Delivery of Nanomedicine to Solid Tumors,FP7,31 July 2015,01 August 2011,100000.0 CANCERBIOMECHANICS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"A miscellany of new strategies, experimental techniques and theoretical approaches are emerging in the ongoing battle against cancer. The objective of the proposal is to model the biomechanical behavior of tumor growth in order to verify the efficiency of anti-cancer therapeutic actions. The main purpose is to study the influence of the structural biology of tumor cells and its vascular network on the determination of the mechanical characteristics of cancerous mass growth. Experiments will be held in synergy with clinicians and biologists, performing both in-vivo and in-vitro (using multi-cell spheroids and monolayer cultures) examinations, with the design and the fabrication of appropriate micro or nano sensing devices. Peculiar and innovative aspects of the modeling effort include: -different chemotactic sensitivities for proliferative and quiescent cells; -regenerative characteristics of hypoxic cells; -investigation of residual stresses and memory of the cancerous mass; -permeability and heterogeneities of capillar blood flow; -collapse of vascular and lymphatic networks; -competition for nutrients with other cell populations (i.e. immune system); -diffusion of apoptic and necrotic cells. The theoretical analysis of the mechanical properties of solid tumor growth, enhanced by the results of numerical computations, will be focused on describing the functional relation that links growth and stress, and the stability thresholds leading to resorption or collapse features. A subsequent step in the proposal consists in the observation and the evaluation of the interaction of the tumor mass with various therapeutic agents. Once detected the level of drug penetration, simulation tools will be used to compare the effectiveness of various anti-cancer clinical treatments.",Biomechanical modeling of tumor growth in oncology,FP6,31 August 2009,01 September 2007,150237.32 CANCERHYDROGELPATCH,Queen Mary University of London,health,"The World Health Organization and the American Cancer Society states that colorectal cancer is one of the most frequent cancers in Europe and in USA. Surgery is the primary form of treatment. Nevertheless, recurrence following surgery is a major problem and is often the ultimate cause of death. Previous therapies have not provided sufficient specificity and structural guidance to promote tumour inhibition after remission, as well as the full regeneration of injury tissue after surgery. Accordingly, our specific aim is to target colorectal tumours cells with hydrogels-drug-siRNA nanorods conjugates after surgery removal of the tumour in in vivo mice models of colorectal cancer. Drug conjugates (i.e. Bevacizumab, Cetuximab, Panitumumab) will be designed to specifically target cancer related growth factor receptors. These drugs will be associated with siRNA molecules against key genes in colorectal cancer progression (EpHB2, EGFR, Wnt) that will be specifically and local delivered in tumour cells. The ultimate goal of the project is to create a sort of patch made of the bioresorbable biomaterial like hydrogels impregnated with drug-siRNA conjugates for locally release in colorectal tumoral cells. At the same time, the hydrogel-nanoparticles functionalized with adhesion proteins like collagen, fibronectin and RGD will be designed as a scaffold with a polymeric core and an adhesive shell for enhanced attachment, proliferation, and phenotypic maintenance of intestinal endothelial and stem cells, as well as for the release of growth factors like insulin and EGF. To the best of our knowledge, this is the first time that a multi-parallel solution to in vivo gene/drug delivery combined to soft tissue engineering applications to promote endothelial and stem cell adhesion, proliferation and migration is proposed. This proposal achieves the aims of the European Research Area and is highly relevant to the Marie Curie Programme and to long-term carreer development.",Hydrogel-nanoparticle patches as prophylactic scaffold agents for in vivo local gene/drug delivery in colorectal cancer tumours.,FP7,30 April 2017,01 May 2014,294219.0 CANDICE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),manufacturing,"The overall objective of this 3-year project is to develop a CMOS-compatible industrial process for the fabrication of field effect transistors based on carbon nanotubes (CNT-FETs). In order to solve the CNT manipulation and placement problems, two approaches based on template growth in engineered porous structures will be investigated. In the first one, CNTs will be grown inside porous alumina templates obtained by anodic oxidation of Al films. The originality of the method is that the pores are synthesised parallel to the surface of the substrate (instead of perpendicular as usual) which will greatly ease the contacting operations for the source, drain and gate electrodes of the CNT-FETs with large numbers of CNTs connected in parallel. In the second approach, CNTs will be grown in vertical pore structures obtained by nanolithography and reactive ion etching. In both cases, the catalyst particles (necessary for the nucleation and growth of CNTs at low to medium temperature) will be electrodeposited at the bottom of the pores prior to chemical vapour deposition growth of the CNTs. As the catalyst particles are confined inside the pores, high temperature surface diffusion is prevented during (or before) growth and the nanometric size of the particles is preserved, leading to uniform CNT diameters. Moreover, by using monocrystalline films or substrates at the bottom of the pores, we propose to deposit the catalyst particles in an epitaxial-type mode, which will lead to a perfectly controlled structure likely to induce chirality control for the CNTs. This point is of paramount importance for the future of CNT-based electronics. The project brings together 4 European partners with complementary skills, from 3 different countries. If the proposed approach is successful, only Europe would have the critical size to set up new standards and industrial practices for CNT-based electronics. It is therefore essential that such research is carried out at European level.",Carbon Nanotube Devices for Integrated Circuit Engineering,FP6,31 August 2008,31 August 2005,1200000.0 CANDO,University of Valencia * Universitat de València,health,"Through further development, integration and validation of micro-nano-bio and biophotonics systems from previous projects CanDo will develop an instrument that will permit the identification and concentration determination of rare cells in peripheral blood for two key societal challenges, early and low cost anti-cancer drug efficacy determination and cancer diagnosis/monitoring. A cellular link between the primary malignant tumor and the peripheral metastases, responsible for 90% of cancer-related deaths, has been established in the form of circulating tumor cells (CTCs) in peripheral blood. Furthermore the relatively short survival time of CTCs in peripheral blood means that their detection is indicative of tumor progression thereby providing in addition to a prognostic value an evaluation of therapeutic efficacy and early recognition of tumor progression in theranostics. In cancer patients however blood concentrations are very low ( = 1 CTC/1E9 cells) and current detection strategies are too insensitive, limiting use to prognosis of only those with advanced metastatic cancer. Similarly problems occur in therapeutics with anti-cancer drug development leading to lengthy and costly trials often preventing access to market. There is therefore a clear need for a novel analytical platform capable of highly reproducible and reliable identification of CTC concentrations of interest in an easily accessible format. With all relevant industrial stakeholders and users onboard CanDo is uniquely capable of delivering such a platform. Its novel cell separation/SERS analysis technologies plus nucleic acid based molecular characterization will provide an accurate CTC count with high throughput and high yield meeting both key societal challenges. Being beyond the state of art it will lead to substantial share gains not just in the high end markets of drug discovery and cancer diagnostics but due to modular technologies in others e.g. transport, security and safety and environment.",A CANcer Development mOnitor,FP7,28 February 2017,01 January 2014,4000000.0 CANEL,Chalmers University of Technology * Chalmers Tekniska Högskola,information and communications technology,"We will study nanoelectromechanical devices in which the mechanically active component is a carbon allotrope - a nanotube, a fullerene molecule, or a so-called peapod. Our objective is to fabricate, analyse and optimise carbon-based nanoelectromechanical devices and to integrate them with silicon technology. We will focus on applications in information technology such as switches and memory elements. Carbon allotropes are ideal for nanoelectromechanical systems (NEMS). They combine extraordinary strength with low mass, thereby extending the frequency range of NEMS far beyond the present limits. The electrical properties of carbon-based structures allow for a large variety of electrical functions to be realised in a circuit utilising a single materials platform. Structurally the carbon allotropes fall into three categories: nearly spherical fullerenes of ca 1 nm in diameter, elongated carbon nanotubes (CNTs) of similar diameters but up to several micrometers long, and 'peapods', CNTs containing fullerenes. The programme's three research areas are based on the nature of the mechanically active element. Each covers fabrication, measurements and modelling. The CNT-based devices utilise a suspended nanotube as the mechanically active element either in a nanorelay or a single-electron transistor configuration. In fullerene-based devices the basic structure consists of a fullerene placed in a nanogap between two electrodes. In peapod structures the mechanical degree of freedom is connected with the fullerene motion inside the CNT as well as into and out of the CNT. Integration of carbon-based NEMS to silicon technology is crucial and forms its own research direction. Integration challenges for the three research areas are similar covering preparation of specialised substrates for carbon-based structures and process and signal compatibilities between the different technologies.",Carbon-based nanoelectromechanical devices,FP6,31 May 2007,31 May 2004,1800000.0 CANTOR,Tel Aviv University,energy,"The efficiency of traditional semiconductor solar cells is subject to a fundamental limitation, known as the Shockley-Queisser recombination limit, and is found to be near 30 per cent. The invention in the early eighties of solar cell rectifying antennas (rectennas) - a combination of an optical antenna and a rectifying diode to efficiently absorb the incident solar radiation and directly convert the ac field across the antenna into the dc power - provides a way to overcome the limitation. The recent rapid technological progress in the design of different nano-dimensional structures gives rise to a new promising possibility in designing nanorectennas. A solar cell will incorporate a large array of such elements, which provide high conversion efficiency and can be produced cheaply in a roll-to-roll process. However, a practical realization of such devices requires precise theoretical modelling and experimental study to provide optimization of the antenna and nanocontact configuration. The project focuses on the physics and theoretical modelling of the nanorectenna performance. The rectification effect comes from the photo-assisted charge carrier tunneling through the nanotube energy gap. For the efficiency enhancement we propose using the coherent effect of the photon dressing of electron-hole pairs. Theoretical modelling will be carried out on the basis of the Landauer- Büttiker formalism extended to the case of photon-dressed electrons. The fundamental thermodynamic limitation of the rectenna efficiency and the prospective applications of the device will be studied. This multidisciplinary and challenging project relies on the complementary expertise of the consortium teams and is based on an original approach - nanoelectromagnetics -combining the electrodynamics of mesoscopic inhomogeneous media and quantum transport theory of charge carriers in structures with reduced dimensionality.",Carbon-nanotube-based terahertz-to-optics rectenna,FP7,31 December 2017,01 January 2014,91200.0 CARBENELECTRONICS,University of Fribourg * Université de Fribourg,information and communications technology,"We propose transition metal complexes containing N-heterocyclic carbene ligands as novel organometallic components for applications in molecular electronics. These complexes are particularly attractive as they combine the characteristics of state-of-the-art (organic) materials for electronics with new properties that are imposed by the transition metal center, thus giving bi- or multifunctional devices. When appropriately engineered, the proposed systems will disclose a potentially new generation of components for molecular electronics. Multiple functionality (e.g. semiconducting and switching features) is expected to have a high impact on data processing and storage devices. The proposed organometallic complexes consist of redox-processable metal centers such as iron or ruthenium as active sites that can be tailored by ligand tuning. Effective ligand tuning is anticipated by using chelating carbene ligands, which allow the metal properties to be influenced by pi-bonding, hardness, bite angle, and rigidity of the ligand. This approach allows for balancing the steric and electronic properties of the active site, and simultaneously, for stabilizing the metal center sufficiently for application in materials science. Suitable components ideally display typical characteristics of molecular switches. This comprises at least two different states that can be addressed selectively. We will consider both, chemical and physical triggering of the switches, though the latter will be preferred due to reversibility issues. We suggest crystal engineering and (self-)assembled monolayers as methods for processing molecular switches into assembled devices. Beneficial intermetallic interactions are expected from the close spatial arrangement of the (redox-)active sites. This is proposed to lead to a concerted rather than an independent mode of action of the metal centers and hence to cooperative effects. Such intelligent materials may be more sensitive than monomolecular systems.",Probing Molecular Electronics with Organometallic Components: Exploiting Metal-Carbene Derived Molecular Switches into Electronic Devices,FP6,31 August 2007,01 September 2005,0.0 CARBIO,Leibniz Institute for Solid State and Materials Research Dresden * Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden eV,health,"We will exploit the potential of multi-functional carbon nanotubes (CNT) for biomedical applications, in particular to act as magnetic nano-heaters, drug-carrier systems and sensors for diagnosis and therapy at a cellular level. CNT are hollow tubes (with 1, 2 or more walls) which can be filled with suitable materials and also be biofunctionalised, i.e. made compatible to biological environment. The long-term objective of the RTN is to develop and optimise multi-functional CNT for human medical applications – with a focus on anti-tumour therapy – which allow targeted release of heat or drugs in diseased cells. For this aim, combined multidisciplinary efforts are necessary ranging from the synthesis, thorough investigation and biofunctionalisation of CNT to studies of their interaction (toxicity, biocompatibility) with biological environments and their diagnostic/therapeutic usability. Hence, a broad multidisciplinary approach in the crossover between physics, chemistry, biology, biochemistry, biophysics, engineering and medicine has to be applied and a new generation of scientists has to be trained. We will do this by addressing 11 strongly interacting work packages which cover all aspects of experimental biomedical nanoscience on the basis of targeted research on multi-functional CNT. Additional local and network-wide training activities, training in complementary skills dedicated to research in biomedical nanoscience (ethical and safety aspects, patents etc.), and the cooperation with industrial partners will guarantee the complete education in this innovative field of applied science. The RTN addresses major objectives of FP6 by combatting a global disease whilst involving nanobiotechnology and creating a new multidisciplinary training structure. The possible application of CNT in tumour therapy highlights the fact that by addressing the combat of a major global disease basic research can find direct applications concerning wider parts of society.",Multi-functional carbon nanotubes for biomedical applications,FP6,30 September 2010,01 October 2006,3050500.0 CARBONANOBRIDGE,University of Trieste * Università degli studi di Trieste,health,"We propose the development of novel nanodevices, such as nanoscale bridges and nanovectors, based on functionalized carbon nanotubes (CNT) for manipulating neurons and neuronal network activity in vitro. The main aim is to put forward innovative solutions that have the potential to circumvent the problems currently faced by spinal cord lesions or by neurodegenerative diseases. The unifying theme is to use recent advances in chemistry and nanotechnology to gain insight into the functioning of hybrid neuronal/CNT networks, relevant for the development of novel implantable devices to control neuronal signaling and improve synapse formation in a controlled fashion. The proposal s core strategy is to exploit the expertise of the PI in the chemical control of CNT properties to develop devices reaching various degrees of functional integration with the physiological electrical activity of cells and their networks, and to understand how such global dynamics are orchestrated when integrated by different substrates. An unconventional strategy will be represented by the electrical characterization of micro and nano patterned substrates by AFM and conductive tip AFM, both before and after neurons have grown on the substrates. We will also use the capability of AFM to identify critical positions in the neuronal network, while delivering time-dependent chemical stimulations. We will apply nanotechnology to contemporary neuroscience in the perspective of novel neuro-implantable devices and drug nanovectors, engineered to treat neurological and neurodegenerative lesions. The scientific strategy at the core of the proposal is the convergence between nanotechnology, chemistry and neurobiology. Such convergence, beyond helping understand the functioning and malfunctioning of the brain, can stimulate further research in this area and may ultimately lead to a new generation of nanomedicine applications in neurology and to new opportunities for the health care industry.",Neuron Networking with Nano Bridges via the Synthesis and Integration of Functionalized Carbon Nanotubes,FP7,31 January 2014,01 February 2009,2500000.0 CARBONCHIP,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"In microelectronic research huge expectations have been created for carbon nanotube (CNT) based nanotechnologies, actually to a level that the microelectronics industry has adopted CNT based nanotechnologies as an important and high potential route for post CMOS nanoelectronics. There is a major gap in basic knowledge to the extent that a detailed understanding of CNT growth mechanisms is still absent and control of the synthesis process to produce nanotubes with the desired diameter and chirality is lacking. CARBonCHIP will address the potential of the integrated CNT technology through an interdisciplinary approach based on (i) the research and development in catalysis, (ii) the growth of CNTs, (iii) the technology of CNTs on-chip, (iv) the related analysis methodology for control of properties and (v) the CNT device for nanoelectronics The objectives of CARBonCHIP match the real challenge for CNTs to be valuable for Nanoelectronic applications. The outcome of the project will have a large impact on future nanoelectronic strategies, since it will assess - the eligibility of CNTs for up-scaled process technology with Si - the feasibility of nanoelectronic application domains. The ultimate goal is to produce a materials based roadmap for further development of the CNT as a viable building block in nano-transistor IC devices, where CNT/Si integrated devices will extend Moore's Law towards the year 2020 and beyond, when CNT technology will complement, and eventually replace nano-lithographic techniques to facilitate 16nm, 11nm and 8nm transistor node development. The consortium consists of an industrial end user (Intel), two renowned research centers (LETI and IMEC), two SMEs (Alchimer and Nanocyl) and a University (KULeuven). The strength of this consortium is that it will bring basic research and the innovative product development of SMEs to the end user, through the research and development of the research institutes",Carbon Nanotubes technology on Si IC's,FP6,31 March 2009,01 April 2006,3549500.0 CARBONCOMP,Global Nanotechnologies SA,information and communications technology,"One of the major obstacles in the effective use of nanostructured carbon as reinforcement in polymer matrix composites is their agglomeration and poor dispersion within the metallic matrix. To overcome this obstacle the proposed project will synthesize and functionalize nanoscaled polymers of carbon nanotubes (mainly) and graphene sheets by employing environmentally friendly and cost-effective methods. Lab-scale production of carbon-based nanocomposites will be initially implemented, primarily for marine coatings but also for other applications where materials performance or biodegradability is of major importance.",High-throughput development of carbon-polymer nanocomposites for marine applications,FP7,08 July 2017,09 January 2011,0.0 CARBONCROFS,University of Crete * Panepistimio Kritis,information and communications technology,"The CarbonCROFs proposal is directed at the rational design and development of novel open-frameworks solids including metal organic-, zeolitic imidazolate- and covalent organic-frameworks well as their smart combination with carbon nanostructures (carbon nanotubes and graphene) towards advanced, multifunctional hybrid nanoporous materials. The combination of the unique and diverse physical and chemical properties of carbon nanostructures such as high surface area, increased chemical and mechanical stability in conjunction with the remarkable properties of final open framework nanoporous composites, is strongly expected to deliver tailor made, hybrid, composite materials showing a very promising potential to serve clean energy (such as hydrogen and fuel cell) technologies. In this respect, the CarbonCROFs project is aiming at the development of composite nanoporous materials featuring:",Rational Design of Hybrid Nano-porous Composites made from Carbon Nanostructures and Crystalline Open-Framework Solids for Advanced Applications,FP7,,,0.0 CARBONLIGHT,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Graphene, a one-atom-thick layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, charge carriers have an effective mass of zero and a very high mobility, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronics, graphene has recently been recognized as a photonic material for novel optoelectronic applications. Interestingly, graphene is also a promising host material for light that is confined to nanoscale dimensions, more than 100 times below the diffraction limit. Due to its ultra-small thickness and extremely high purity, graphene can support strongly confined propagating light fields coupled to the charge carriers in the material: surface plasmons. The properties of these plasmons are controllable by electrostatic gates, holding promise for in-situ tunability of light-matter interactions at a length scale far below the wavelength. This project will experimentally investigate the new and virtually unexplored field of graphene surface plasmonics, and combine this with other appealing properties of graphene to demonstrate the unique potential of carbon-based nano-optoelectronics. The aim is to explore the limits of unprecedented light concentration, manipulation and detection at the nanoscale, to dramatically intensify nonlinear interactions between photons towards the quantum regime, and to reveal the subtle effects of cavity quantum electrodynamics on graphene-emitter systems. This research will reveal the far-reaching potential of a single sheet of carbon atoms as a host for light and electrons at the nanoscale, with prospects for novel nanoscale optical circuits and detectors, nano-optomechanical systems and tunable artificial quantum emitters.",Tunable light tightly bound to a single sheet of carbon atoms: graphene as a novel platform for nano-optoelectronics,FP7,31 October 2017,01 November 2012,1466000.0 CARBONNEMS,ICN2 - Institut Català de Nanociència i Nanotecnologia,information and communications technology,"Carbon nanotubes and graphene form a class of nanoscale objects with exceptional electrical, mechanical and structural properties. I propose to exploit these unique properties to fabricate and study various nanoelectromechanical systems (NEMS) based on graphene and nanotubes. Specifically, I will address two directions with major scientific interests:",NanoElectroMechanical Systems based on Carbon Nanotube and Graphene,FP7,12 July 2018,01 January 2012,0.0 CARBONQUBITS,Eotvos Lorand University * Eötvös Loránd Tudományegyetem,information and communications technology,"Quantum computation (QC) is expected to improve the efficiency of certain computational tasks. QC schemes are formulated in terms of operations on quantum bits (qubits), whose values are superpositions of two quantum states. A natural candidate for the physical implementation of a qubit is the spin of an electron. In fact, breakthrough experiments recently demonstrated the ability to initialize, manipulate, couple and read out spin-based qubits using electrons confined in a solid state environment. New perspectives have been opened in solid-state QC by recent proposals exploiting the peculiar characteristics of carbon nanotubes (CNTs): utilizing electronic states circulating around the CNT circumference in qubit implementation is promising for various reasons. To evaluate the potential in these novel qubit realizations, we plan to develop a profound theoretical understanding of the physical mechanisms allowing initialization and readout of the qubit, causing two-qubit interactions, as well as those leading to the loss of information encoded in the qubit. We expect that our results will enable the design of carbon nanostructures optimized for QC, provide understanding of related recent and future experiments, and highlight fundamental new quantum-physical phenomena on the nanoscale.",Quantum Bits in Carbon Nanostructures,FP7,08 July 2017,09 January 2011,0.0 CARBOPREC,Arkema Group,energy,"More and more industrial sectors (e.g. automotive, wind energy, boatbuilding) are demanding lightweight and high-performance composite materials, which represent a strong driver to develop the carbon fibre (CF) industry. Today, almost 80% of CF available on the market are using PolyAcryloNitrile (PAN) as the starting raw material because of its superior properties compared to pitch based carbon fibres. However, CF produced from PAN are expensive which limit their application to premium industrial sectors looking for high-performance structural materials while accepting high material costs (e.g. aeronautics, military devices, and sport goods). The strategic objective of CARBOPREC is to develop low cost precursors from renewable materials widely available in Europe (lignin and cellulose) reinforced by carbon nanotube (CNT) to produce high performance CF for automotive and wind energy applications. To achieve this objective, two white fibre processes will be studied to produce continuous fibers: - wet spinning approach for the cellulose dissolved in phosphoric acid (H3PO4), - melt spinning by extrusion for the lignin. Moreover, the carbonization process as well as the different functionalisation steps will be deeply investigated to enhance significantly both, the carbonisation yield, and the added value brought by the developed carbon fibers in the final applications targeted. The CARBOPREC consortium led by ARKEMA gathers 14 partners coming from 6 different European countries and Russia. It covers the whole value chain needed to develop innovative carbon fibers from renewable materials.",Renewable source nanostructured precursors for carbon fibers,FP7,31 December 2017,01 January 2014,5968027.0 CARBOSORB,University of Brighton,environment,"The aim of this project is to develop and manufacture permeable composite “filters” in which carbon-rich nanoparticles (or nanoporous materials) will be embedded (and contained in a recyclable 3D structure), and use these as the basis of recyclable, high performance water clean-up devices, for application in the environmental and industrial sectors. It brings together a multidisciplinary consortium of specialists in different areas of environmental (geo)chemistry, nanotechnology, and physical, analytical, synthetic, polymer and surface chemistry, working with a common aim of developing new and efficient methods of contaminant removal from surface and groundwaters, drinking waters, and trade and industrial effluents.",CARBOSORB - Carbon (Nano) Sorbents for Environmental Remediation,FP7,04 June 2015,05 January 2009,1284892.0 CARBOTRON,Lancaster University,information and communications technology,"Molecular electronics has the potential to go well below the size limitations of silicon-based electronics, such that the well known Moore's law can be maintained for much longer than with silicon alone. Without advances in nanoscale/molecular electronics, future computers would not be able to continue the current pace of development over the next twenty years. Molecular electronics can reduce the size of semiconductor rectifiers to the nanoscale by using single molecules as rectifiers. In addition, molecular electronics can also pave the way to single molecule sensing, which is an important part of the improvement of next-generation health care involving highly sensitive detection of toxic materials.",Carbon-based nanoelectronics,FP7,04 June 2016,05 January 2011,0.0 CARBOTRONICS,University of Cambridge,photonics,"Project covers theortical/computational studies of optoelectronic properties of graphene and other carbon-based nanostructures, aimed at both fundamental effects and application in future graphene nanotechnology. Major goals are: (i) learning new, powerful methods of electronic-structure calculations (quantum Monte Carlo and density functional theory) and their application for graphene nanostructures; (ii) learning methods of field theory and combining them with extensive present expertise for the studies of many-body effects in electronic and optical response, with expected application in novel nanodevices; (iii) learning complementary skills for establishment of home interdisciplinary research group focused on nanoscience/nanotechnology of new structures/materials and integrated with big EU research programmes (leadership skills, acquiring funds, project management, work in collaboration); (iv) acquintance with (and import of) teaching methods/practices (excellence in this academic skill being crucial for Applicant's promotion to a full professor upon return). Project's success relies on Applicant's present potential/experience (mostly in fundamental research, but also in teaching and leadership) and on superb quality of the host (Cambridge in general, Cavendish Laboratory in particular) in all essential aspects (research, participation in European science, and teaching). The main results will be: (i) multi-aspectual individual education of the Applicant (at a rate possible only due to continuous interaction with Europe's best specialists and exposure to unparalleled academic environment) as well as (ii) enhancement of attractiveness and potential of European science by means of transfer of knowledge and research/academic habits from the leading European university to a major but still rapidly developing research/academic institution in Poland and (iii) efficient incorporation of the latter in priority EU research programmes.",Opto-electronic properties of graphene and other carbon nanostructures,FP7,31 August 2010,01 September 2008,234536.0 CARDEQ,Helsinki University of Technology * Teknillinen Korkeakoulu,information and communications technology,"Carbon nanotubes have several unique electrical and mechanical properties. We plan to take advantage of these extraordinary properties by developing nanotube sensors working close to the quantum limit of sensitivity. We propose to extend the operation of HEMT/FET-type of nanotube devices to the quantum limit, and to demonstrate their usefulness in conjunction with a mechanical nanotube resonator serving as a force sensor at sub-attoNewton resolution. The devices to be investigated include a) a high-frequency carbon nanotube FET, b) carbon nanotube rf-SET, and c) superconducting nanotube transistor. Our devices will provide either unsurpassed sensitivity or band width for the detection of charge and mechanical motion. In addition to the development of these three detector-amplifiers, we plan to study the contact resistance between nanotubes and metallic electrodes, the understanding of which is crucial for the optimization of carbon nanotube devices. The final goal is to build a sub-attoNewton force sensor that would act simultaneously as the sensing element and, as well, as its own first stage preamplifier.",Carbon Nanotube Devices at the Quantum Limit,FP6,31 August 2009,28 February 2006,1950000.0 CARERAMM,University of Exeter,information and communications technology,"Carbon offers an exciting route to the realisation of future generations of high-performance, cost-effective, environmentally-friendly, resistive-switching type non-volatile data storage. Scalability to the molecular level, sub-nanosecond switching time, ultra-low power operation, environmental stability, environmental friendliness, simple memory structures, advanced functionality and cost-effectiveness are all features readily provided by carbon-based data storage materials.",Carbon resistive random access memory materials,FP7,01 July 2018,02 January 2013,0.0 CARHAY2011,Haydale Ltd.,information and communications technology,"Carbon fibre reinforced plastics (CFRP) are a composite material normally manufactured from a cloth weaved from carbon fibre cloth set within a thermoset resin. CFRP has an extremely high strength to weight ratio and will play a key part in the reduction of weight in aircraft structures and hence emissions. It has been proposed that the use of a nanofilled thermoset resin in the manufacturing of a structural CFRP panel may potentially lead to structural property enhancements (such as impact resistance) as well as to the occurrence of new functional properties (electrical, conductivity, flame retardancy). These enhancements are based on the specific nano filler chosen for the resin production.","Design, Manufacturing and Impact Testing of Advanced Composite Materials",FP7,05 July 2016,12 January 2012,0.0 CARINHYPH,IMDEA Materials Institute * Instituto IMDEA Materiales,information and communications technology,"CARINHYPH projects deals with the hierarchical assembly of functional nanomaterials into novel nanocarbon-inorganic hybrid structures for energy generation by photocatalyic hydrogen production, with Carbon NanoTubes (CNTs) and graphene the choice of nanocarbons. The scientific activities include the development of new functionalisation strategies targeted at improving charge transfer in hybrids and therefore their photocatalytic activity, and in transferring these synergistic effects by assembling the hybrid units into macroscopic structures.",Bottom-up fabrication of nano carbon-inorganic hybrid materials for photocatalytic hydrogen production,FP7,12 July 2017,01 January 2013,0.0 CARTOON,University of South Paris * Université Paris-Sud,photonics,"Primary goal of the proposed research action is the development of a novel strategy for hybridizing silicon based photonic devices, exploiting semiconducting carbon nanotubes (CNT) as integrated light source, modulator and detector. Photonics in Information and Communication Technologies is more and more investigated for a broad application domain. These applications require efficient optoelectronic devices to emit, modulate and detect light. To facilitate photonic and electronic convergence, the envisioned approach is based on the silicon platform. However, the definition of optoelectronic devices requires several kinds of materials (Si, Ge and III-V) as silicon is an indirect-gap material with poor electro-optic properties. This project aims at investigating a new and innovative field through the use of CNT in the near infrared wavelength range. The main breakthrough will come from the development of CNT-based optoelectronic components directly co-integrated within a silicon platform to address the major challenges of photonics. Such integration has never been investigated so far and thanks to a joint experimental and theoretical investigation our major goal is to establish the potential of CNT technology for nanophotonics applications. The project reposes on three major cornerstones: (i) A waveguide detector in the 1.3-1.6µm wavelength range, (ii) integrated optical modulators using Kerr (electro-refraction) and Stark (electro-absorption) effects and (iii) An integrated electrically pumped optical nanosource. Each of these cornerstones will be a world's premiere and will constitute a breakthrough. Inherently, this makes it a high risk/high gain yet achievable proposal with a foundational impact both in knowledge and technology for nanophotonics. In a long term vision the establishment of new state of the art and advanced know-how on optoelectronic devices based on CNT will allow developing and addressing a broad range of applications in information technologies.",CARbon nanoTube phOtONic devices on silicon,FP7,31 October 2016,01 November 2013,1438037.0 CASBLIP,Polytechnic University of Valencia * Universitat Politècnica de València,information and communications technology,"The main aim of this project is to develop a system capable of interpreting and managing real world information from different sources to assist blind or visually impaired users. The system would present the user with enhanced image and audio maps of their surrounding to meaningfully improve the independence-and hence quality of life-of blind and visually impaired people. The system will integrate and improve on previously developed systems from expert research centres: 1) Computer Vision Group at the University of Bristol: They have developed a portable headset which, in real time, can overlay enhanced scene information to people with degraded vision. This is in collaboration with cognitive experts who have worked on ways of simplifying the image content whilst maintaining the most salient information. The researchers at Bristol have worked with blind people and a working prototype was successfully validated. 2) Researchers at Universidad Politécnica de Valencia: They have been working in the development of 3D models useful in applications such as robotics or virtual reality. 3) Universidad de La Laguna and Instituto de Astrofísica de Canarias: They have produced and successfully tested a system to represent spaces as acoustic maps for completely blind people. This was validated in experiments and demonstrated very good results. 4) Siemens AG: They have developed a CMOS sensor able to acquire 3D Real world distance information in real time with high-levels of performance. The combination and improvement of these developments, enhanced by means of cognitive analysis and decision-making can be tailored as an integrated, portable and suitable system for both visually impaired and blind people. This will allow them to benefit from a system tailored for everyday tasks, enabling autonomous navigation while being able to identify potential risks, obstacles and routes.",Cognitive Aid System for Blind People,FP6,31 January 2009,31 January 2006,1999547.84 CASCATBEL,IMDEA Energy Institute * Fundacion IMDEA Energia,environment,"The present project is aimed to the development of a multi-step process for the production of second-generation biofuels from lignocellulosic biomass in a cost-efficient way through the use of tailored nanostructured catalysts. The proposed process is based on the cascade combination of three catalytic transformations: catalytic pyrolysis, intermediate deoxygenation and hydrodeoxygenation. The sequential coupling of catalytic steps will be an essential factor for achieving a progressive and controlled biomass deoxygenation, which is expected to lead to liquid biofuels with a chemical composition and properties similar to those of oil-derived fuels. According to this strategy, the best nanocatalytic system in each step will be selected to deal with the remarkable chemical complexity of lignocellulose pyrolysis products, as well as to optimize the bio-oil yield and properties. Since hydrodeoxygenation (HDO) is outlined in this scheme as the ultimate deoxygenation treatment, the overall hydrogen consumption should be strongly minimized, resulting in a significant improvement of the process economic profitability. The use of nanostructured catalysts will be the key tool for obtaining in each chemical step of the cascade process, the optimum deoxygenation degree, as well as high efficiency, in terms both of matter and energy, minimizing at the same time the possible environmental impacts. The project will involve experiments at laboratory, bench and pilot plant scales, as well as a viability study of its possible commercial application. Thereby, the integrated process will be assessed according to technical, economic, social, safety, toxicological and environmental criteria. The consortium will be formed by 17 partners, including 4 research institutions, 6 universities, 5 large industries and 2 SME.",CAScade deoxygenation process using tailored nanoCATalysts for the production of BiofuELs from lignocellullosic biomass,FP7,10 July 2019,11 January 2013,6380116.0 CASINO,Aarhus University * Aarhus Universitet,health,"Mechanisms governing interaction between multicellular organisms and microbes are central for understanding pathogenesis, symbiosis and the function of ecosystems. We propose to address these mechanisms by pioneering an interdisciplinary approach for understanding cellular signalling, response processes and organ development. The challenge is to determine factors synchronising three processes, organogenesis, infection thread formation and bacterial infection, running in parallel to build a root nodule hosting symbiotic bacteria. We aim to exploit the unique possibilities for analysing endocytosis of bacteria in model legumes and to develop genomic, genetic and biological chemistry tools to break new ground in our understanding of carbohydrates in plant development and plant-microbe interaction. Surface exposed rhizobial polysaccharides play a crucial but poorly understood role in infection thread formation and rhizobial invasion resulting in endocytosis. We will undertake an integrated functional characterisation of receptor-ligand mechanisms mediating recognition of secreted polysaccharides and subsequent signal amplification. So far progress in this field has been limited by the complex nature of carbohydrate polymers, lack of a suitable experimental model system where both partners in an interaction could be manipulated and lack of corresponding methods for carbohydrate synthesis, analysis and interaction studies. In this context our legume model system and the discovery that the legume Nod-factor receptors recognise bacterial lipochitin-oligosaccharide signals at their LysM domains provides a new opportunity. Combined with advanced bioorganic chemistry and nanobioscience approaches this proposal will engage the above mentioned limitations.",Carbohydrate signals controlling nodulation,FP7,30 April 2016,01 May 2011,2399127.0 CATANITSOFC,Consejo Superior De Investigaciones Científicas (CSIC),energy,"Lowering to intermediate temperatures (<750 oC) the functioning regime of solid oxide fuel cells (SOFC), and their operation by directly oxidizing fuels, are important objectives from the economic, environmental and energy efficiency points of view. Here a proposal is made to study new formulations for the anodes in these cells in order to overcome the deactivation problems observed in the case of anodes using nickel (due mainly to carbon deposition) and to improve the efficiency of the anodes based in Cu-CeO2 composites, which are more efficient for achieving this goal. The objective is to develop composites of mixed oxides (Ce-Zr, Ce-Sm, Ce-Gd, Ce-Tb,Ce-Ca and derived ternary ones) based in the cerium oxide structure and copper alloys (e.g. with Fe and Ni) to improve the catalytic activity of the anode and the thermal stability of the copper subsystem against sintering. We propose a complete set of tasks including the materials preparation (using in the mixed oxide synthesis methods like the microemulsion-based ones for obtaining nanoparticles with maximum structural homogeneity), their physico-chemical characterization (using techniques as diffraction and electron microscopy and several spectroscopies, both ex-situ –mainly EPR, IR, Raman HREM and XPS- and under reaction conditions –XANES/EXAFS and DRIFTS-) and the measurement of their electrical properties and chemical and catalytic activities for the oxidation of several fuels (hydrogen, hydrocarbons –methane, long chain linear ones, aromatics- or alcohols), paying particular attention to their deactivation and using kinetic measurements for the study of the reaction mechanisms. Finally, full single-cells will be prepared integrating the thus developed anodes with latest generation ceramic electrolytes and cathode materials, measuring their electrochemical behavior and their energetic efficiency under configurations and operational modes typical for intermediate temperature systems.",New catalytic formulations for anodes of intermediate temperature direct fuel oxidation solid oxide fuel cells,FP6,12 August 2009,13 August 2007,195173.34 CATAPULT,University of Montpellier 2 Sciences et Techniques * Université Montpellier 2 Sciences et Techniques,energy,"Project CATAPULT proposes to develop a radically new concept for automotive PEM fuel cell catalysts based on novel structures wherein platinum is deposited as an extremely thin layer ( <3 nm) on corrosion resistant supports of various morphologies, including particulate, nanofibrous and nanotubular, as well as 'nano-hierarchical' combinations of these. In this approach, platinum is deposited using atomic layer deposition as thin, contiguous and conformal films that allow development of extended platinum or platinum alloy surfaces. Non-PGM catalysts will be developed via the tailored synthesis of metal-organic frameworks for their use either sacrificially to generate the C/N support for non-PGM species, or directly as a non-PGM catalyst. Hybrid ultra-low Pt/non-PGM catalysts and catalyst layers will also be investigated as a further novel approach. Increased fundamental understanding from supporting theoretical modelling will provide guidance to the strategies developed experimentally and to the down-selection of the new corrosion-resistant supports and their supported catalyst designs. Down-selected catalysts will be integrated into novel electrode designs and into MEAs incorporating state of the art membranes best adapted for automotive power trains, and evaluated according to protocols reproducing the stresses encountered in a drive cycle. The candidate MEA best satisfying performance and stability targets will be scaled-up for further assessment at large MEA and short stack levels. Techno-economic assessment will consider the scale up processability, and the impact of MEA performance and durability on stack costs. The well-balanced partnership, comprising two large industries (including an automotive OEM), two SMEs, two research organisations and two universities, will ensure close cooperation between industrial and institute partners, know-how, experience, research leadership, complementarity and industrial relevance.",novel CATAlyst structures employing Pt at Ultra Low and zero loadings for auTomotive MEAs,FP7,31 May 2016,01 June 2013,2255690.0 CATASCIL,RWTH Aachen Institute for Technical and Macromolecular Chemistry * RWTH Aachen Institut für Technische und Makromolekulare Chemie,environment,"Noble metals nanoparticles will serve as catalysts in supercritical fluids-ionic liquids biphasic systems. Hydrogenations, oxidations and C-C bond formations processes are targeted. Higher activities together with good selectivities of the catalysts are aimed. In-situ synthesis on stable nanoparticle is targeted, using as precursors simple salts or organometallic compounds. The simplicity and reproducibility of preparation will be addressed, and hydrogen will be preferred as reductive agent. The effect of ionic liquids structure over the nanoparticle stability and catalytic properties will be established, and the proper ionic liquids will be chose for a longer life the nanoparticles catalytic system. Nanoparticles will be characterized by established techniques (electron microscopy) and size and shape effects on activity and selectivity will be assessed. Supercritical CO2 is considered a solvent with tunable properties, especially around critical point. This property offers further advantages, offering a way for controlling the solubility of reaction product, and allowing a neat separation. Due to the benign character of carbon dioxide, this process may be able to offer a cleaner alternative to classical processes employing molecular solvents. The biphasic system allows a facile separation of the products, stops the leaching of precious metals, and allows a simple and efficient catalyst recycling.",Noble metal nanoparticles catalysis in supercritical fluids-ionic liquids biphasic systems,FP6,31 August 2007,01 September 2005,0.0 CATGOLD,Institut Català d'Investigació Química (ICIQ) * Institute of Chemical Research of Catalonia,manufacturing,We plan to chase new goals by exploring the limits of gold chemistry and organic synthesis. A major goal is to promote copper to the level of gold as the catalyst of choice for the activation of alkynes under homogeneous conditions. Another major goal is to develop enantioselective reactions based on a new chiral catalyst design to overcome the inherent limitations of the linear coordination of d10 M(I) coinage metals. We whish to contribute to bridge the gap between homogeneous and heterogeneous gold catalysis discovering new reactions for C-C bond formation via cross-coupling and C-H activation. We will apply new methods based on Au catalysis to fill the gap that exists between chemical synthesis and physical methods such as graphite exfoliation or laser ablation for the synthesis of nanographenes and other large acenes.,ADVANCING GOLD CATALYSIS,FP7,02 April 2020,03 January 2013,2499060.0 CATHCAT,Technical University of Munich * Technische Universität München,energy,"Novel low temperature fuel cell (FC) cathode catalyst and support systems will be designed and synthesized. The focus will be on highly active catalyst materials for polymer electrolyte membrane fuel cells (PEMFC) for transportation applications. These materials will be fully characterized, benchmarked and validated with a multi-scale bottom up approach in order to significantly reduce the amount of precious metal catalyst loadings (< 0.15 g/kW) and to vastly improve fuel cell efficiency and durability. Thereby, materials compatible and stable under automotive fuel cell environment and conditions will be investigated in order to reach a FC lifetime of 5000h. These targets are highly relevant to the call topic requesting ambitious, highly novel concepts for next generation European membrane electrode assemblies (MEAs) for transportation applications. Numerical simulations will be used in order to identify which alloy compositions to strive for in the experimental work. These alloys will be synthesized both in the form of well defined model compounds as well as in the form of nanoparticles. Different modified support materials will be studied. For the NPs, there will be two stages of preparation, the small scale preparation to create well defined NPs for preliminary assessment of their performance and stability, and, subsequently, up-scaling for MEA production. Supported NP catalysts and model catalysts will be tested using electrochemical methods and Surface Science approaches. After up-scaling MEAs based on improved cathode catalysts and improved supports will be assembled using advanced Nafion- based and high temperature membrane based electrolytes. These will be tested for performance and durability using procedures established in automotive industry and previous EU projects.",Novel catalyst materials for the cathode side of MEAs suitable for transportation applications,FP7,31 December 2015,01 January 2013,1895862.0 CATHERINE,Consorzio Sapienza Innovazione,manufacturing,CATHERINE will provide a new unconventional concept for local and chip-level interconnects that will bridge ICT beyond the limits of CMOS technology._x000d_,Carbon nAnotube Technology for High-speed nExt-geneRation nano-InterconNEcts,FP7,12 July 2012,01 January 2008,0.0 CATNETS,University of Bayreuth * Universität Bayreuth,information and communications technology,"Future Grid network technology will face the problem of the efficient provisioning of services to clients by a scalable and dynamic resource allocation (matching) mechanism. The objective of CATNETS is to determine the applicability of a decentralized economic self-organization mechanism for resource allocation in application layer networks (ALN), by (1) producing a 'proof-of-concept' prototype in a real ALN and (2) by evaluating its performance against existing resource brokerage approaches in a simulated ALN. The term ALN integrates different Internet overlay network approaches, like Grid and P2P systems. The allocation of resources in these networks (e.g. matching of demand and supply, deployment of service instances, and service discovery) can principally be conducted in a centralized (e.g. using resource brokers) or in a decentralized fashion (e.g. using self-organizing mechanisms). Centralized approaches reach their limits with increasing network size and growing numbers of elements; self-organizing approaches thus gain attention, e.g. in IBM's Autonomic Computing initiative. The CATNETS project investigates a 'free market' economic self-organization approach, the 'Catallaxy' by Friedrich A. von Hayek, as the basis for self-organizing resource allocation in ALNs. A preliminary evaluation of 'Catallactic' mechanisms in the FET assessment project CATNET (IST-2001-34030) by simulation has shown positive results, upon which the CATNETS project will build. The performance measurements of the 'proof-of-concept' implementation will be compared against the simulation results, with the goal of being able to make a substantiated statement on the applicability of economic self-organization as a major component of ALN networks. A positive evaluation of the Catallactic approach would have a high potential impact, with new possibilities for resource brokering in future ALN, and maybe for self-organization in computing in general.",Evaluation of the Catallaxy paradigm for decentralized operation of dynamic application networks,FP6,31 August 2007,31 August 2004,1414000.0 CCCAN,Technical University of Berlin * Technische Universität Berlin,information and communications technology,The aim of this project is to understand and control the fundamental physical properties of novel carbon nanomaterials:,Characterizing and Controlling Carbon Nanomaterials,FP7,11 June 2017,12 January 2010,0.0 CCQCN,University of Crete * Panepistimio Kritis,information and communications technology,"The Crete Center for Quantum Complexity and Nanotechnology focuses on theoretical, experimental and computational research in Condensed Matter Physics and applications. The majority of its members are professors of the Department of Physics of the University of Crete, a leading, research oriented Department in Greece. The Center aims at advancing individual and collective research, perform collaborative work in broad areas such as magnetics and magnetic devices, correlated electronic systems, metamaterials, graphene, complex systems, field theory, nanoscience, nanotechnology, etc and transform the unit into a world class establishment for condensed matter physics, the physics of complex systems and materials applications. The Center will upgrade significantly its already good experimental low temperature and micro-nanoelectronics facilities while, additionally, it will establish a state of the art computational facility where competitive computational research work may be performed. The large number of young experienced researchers to be hired will facilitate as well as advance collaborative research work in the focus areas. The interaction and twinning with top European institutions and the strong visitors and conference organization program will enable major advancements in research and turn the facility into a Center of Excellence with long term viability.",Crete Center for Quantum Complexity and Nanotechnology,FP7,02 April 2019,09 January 2013,4811000.0 CD-MEDICS,Rovira i Virgili University * Universitat Rovira i Virgili,health,"The overall concept of the CD-MEDICS IP is to develop a technology platform for point-of-care diagnostics, capable of simultaneous genomic and proteomic detection, with embedded communication abilities for direct interfacing with hospital information systems. This will be achieved by exploiting breakthroughs at the confluences of bio-, micro- and nano- technologies to create a low-cost non-invasive intelligent diagnosis system. This platform will be developed in a modular format, which will allow each module to be developed and exploited individually. The modules will subsequently be integrated to facilitate the desired application. Advances in data communications, molecular biology and biosensor technology, with the integration of nanostructured functional components in macro and microsystems, will facilitate the realisation of a minimally invasive generic platform, which is capable of multi-parametric monitoring and will be interoperable with electronic medical records. The advantages of integrated biosensor systems include their ease of use, their sensitivity, their inherent selectivity (preventing problems due to interfering substances), their versatility (allowing 'in-field' use) and their cost effectiveness. Addressing the future health care requirement of an individualised theranostic approach, the specific application that will be demonstrated in this IP will be for the management, monitoring and diagnosis of coeliac disease, with the proposed technology contributing to significant advances in sensitivity and specificity of diagnosis. The technology platform developed, however, could be applied to a variety of clinical screening applications, such as cancer. The radical innovation proposed in this IP will result in a concrete prime deliverable of a technology platform of wide application and unquestionable socio-economic benefit, increasing European competitiveness whilst contributing considerably to the quality of life well-being of the population.","Coeliac Disease -Management, Monitoring and Diagnosis using Biosensors and an Integrated Chip System",FP7,31 July 2012,01 February 2008,9500000.0 CD14,University Hospital Göttingen * Universitätsmedizin Göttingen,health,"According to the project 'Fighting against cancer today' (FACT, funded by the EU 2008), molecularly targeted drugs with associated sophisticated diagnostic systems to personalize care are likely to have a great impact on cancer control in Europe. At the same time, drug delivery is going to be progressed by nanomedicines that can ferry high amounts of active drugs to the tumor. A recent achievement in developing drug delivery systems are bacterially-derived mini- or nanocells that appear to be superior to other nanovector systems, e.g. in terms of stability or packaging versatility, and that aim reaching high therapeutic efficacy with low to no toxicity. This drug-delivery system has been developed by EnGeneIC Pty Ltd in Sydney, Australia. A critical issue of the application of bacterially-derived nanocells to human beings is their inherent capability to provoke adverse immune responses, i.e. via the LPS receptor CD14. Cellular responses to this vector, to be determined as changes in the composition or the activity status of subsets of peripheral blood cells, will be addressed by this proposal. Parallel investigations will yield clues on whether individual genetic variations in molecules determining LPS sensitivity do affect safety and/or efficacy of the delivery system. Moreover, individual genetic variations in drug metabolizing molecules as well as tumor genetics will be assessed in view of therapy outcome predictivity. Research and evaluation of applicability to patients in Europe will be continued at the return host institution, the University Medical Center in Göttingen, which cares for about 13.700 cancer cases yearly, which has a strong focus on molecular tumor diagnostics and individualized medicine within the Department of Gastroenterology, and which provides expertise by experienced specialists as do the German Primate Center or the Max Planck Institutes. Collaborations are strongly envisaged to transfer knowledge most efficiently.",Innate and adaptive immune responses to nanocell-based tumor-targeted cancer therapeutics,FP7,28 February 2013,01 March 2010,330100.0 CDX NANOWIRES,National Institute of Materials Physics * Institutul National de Cercetare-Dezvoltare pentru Fizica Materialelor,energy,"Preparation and study of nanowires is one of the most promising domains of the field of nanotechnology. Up to now the reports published in the area described mainly methods of preparation, structural and morphological characterization. For transport characterization expensive preparation methods for the contacts were required as electron or submicrolithography. The aim of the present project is the preparation and a complete characterization of cadmium chalcogenites nanowires by electrodeposition in ion track templates. The templates will be polymer films (up to several tenths of micrometers thickness) irradiated with swift heavy ions. By controlled etching of the damage trail left by the ions in the materials, pores with the desired shape and dimension can be obtained. The electrochemical replication of the pores will result in arrays of nanowires in the case of multipores membranes or single nanowires in the case of single pore membranes (films which were irradiated with a single ion). The multiwire arrays samples will be used for morphological (electron microscopy), structural (X- ray and electron diffraction) and optical (absorption spectroscopy, luminescence) characterization. The single wire samples will be used for transport characterization - conductivity and photoconductivity in a wide range of temperatures, transport in magnetic fields. The results will be a first step in preparation and characterization of nanowire based semiconductor functional devices, the possible field of application being extremely wide: light sensors (both photoconductivity and photovoltaic detectors), light emitting devices as LEDs and laser diodes, temperature sensors and so on. The project can be considered as an alternative to the much more expensive methods of preparation, especially for the electric contacting of the nanowires.",Preparation and study of cadmium chalcogenites nanowires,FP6,30 June 2005,01 July 2004,40000.0 CEESC,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"The promise of nanoscience stems from the fundamentally new behavior that emerges at the nanoscale. Here, we propose to explore, control and exploit one of the most dramatic aspects of this unusual behavior: quantum entanglement of spins. Our nanoscale system of choice is an array of semiconductor quantum dots that each contain one single electron. Thanks to a string of recent breakthroughs, it is now possible to initialize, coherently manipulate and read out the spin state of one such electron, and to couple it coherently to a spin in a neighboring dot. Today, we are at the brink of a new era in this field, in which entanglement will play the central part. The primary goal of this proposal, therefore, is to experimentally demonstrate that electron spins in quantum dots can really be entangled, and to control this entanglement in time. We will then use this capability to implement various quantum information protocols such as quantum algorithms and teleportation, which intrinsically rely on entanglement to realize tasks that are classically impossible. In order to push the level of coherent control to its limits, we will suppress fluctuations in the normally uncontrolled spin environment, and pursue novel quantum dot technologies which offer an intrinsically ‘quiet’ environment. Our long-term dream is to demonstrate that the accuracy threshold for fault-tolerant quantum computation can be reached in this system, which would permit quantum coherence and entanglement to be preserved indefinitely. This research is presently very much at the stage of exploratory research and is bound to produce surprising and unexpected outcomes. Furthermore, we are convinced that pushing the frontier of quantum control in nanoscale devices has a real potential to lead to future quantum technologies.",Control of entangled electron spins on a chip,FP7,06 June 2015,07 January 2008,1296000.0 CELL POLARITY,Free University of Berlin * Freie Universität Berlin,health,"The ability of cells to polarize is crucial for development, wound healing, and neurotransmission. As many cellular polarity factors play central roles in disease (e.g. cancer, neurological dysfunction) understanding the molecular basis of cell polarity is of great importance to the biomedical sciences. One central aspect of cell polarity involves the regulation of the cytoskeleton and membrane-trafficking machinery, leading to the delivery of specific proteins and lipids to distinct cellular subdomains. This polarized membrane traffic seems important for cells that exhibit local cell growth, including migrating cells. Using advanced imaging approaches I showed that migrating cells preferentially deliver their secretory vesicles towards the leading edge (i.e. the front), and that this polarized delivery depends on intact microtubules (MTs). But how MTs and polarized membrane traffic contribute to cell migration remains unclear. Recent work on wound-edge migrating cells has identified factors that lead to distinct MT polarity phenotypes, i.e. MT stabilization and centrosome orientation, both of which could contribute to bias membrane traffic towards the front of the cell by either forming specialized vesicular tracks or by positioning secretory organelles in front of the nucleus. I will use interdisciplinary cell biological and state-of-the-art imaging and screening approaches to 1) investigate the mechanism of how MT polarity and polarized membrane traffic contribute to directed migration using known factors, 2) identify membrane trafficking factors that play a role in directed migration using automated image-based screening and 3) investigate the role of common traffic/migration factors in polarized membrane traffic and MT polarity. Further, I will implement 'super-resolution' microscopy to image the nanoscale localization of polarity factors in greater detail. These studies are aimed toward a more comprehensive understanding of cell polarity.",Role of Microtubule Polarity and Polarized Membrane Traffic in Directed Cell Migration,FP7,30 April 2014,01 May 2010,100000.0 CELL-O-MATIC,Technical University of Denmark * Danmarks Tekniske Universitet,health,"We propose a technology that will sit at the front-end of sequencing pipelines, present and future, and will significantly enhance the quality and throughput of DNA sequencing. Although much attention has been given to throughput/cost of the sequencing process itself, the same cannot be said for the preparation of samples. Identified bottlenecks are (1) sequencing technologies require days of upfront sample preparation which is further increased when sequencing selected parts of the genome; (2) genome assembly relies on computationally intensive comparisons to the reference genome because existing technologies produce short sequence reads; (3) it is difficult to begin with small amounts of sample material comprising micro-biopsies and single cells. The CELL-O-MATIC project will synergize efforts from SMEs, academics and large companies to address these bottlenecks by developing chip-based systems that process DNA from individual cells, ready for next generation high-throughput sequencing. Single cell analysis has numerous applications in systems biology but we will emphasize DNA isolation and sequencing from circulating tumor cells (CTC), which have a strong prognostic value in cancer management. A second innovation will be to develop methods that enable up to whole chromosome lengths of DNA to be contiguously mapped using nanofluidics. The inclusion of nanofluidics makes the project particularly distinctive and introduces European SMEs to an area that so far has been the domain of US companies. A modular prototype comprising, a chip, fluid and thermal control, sonication and optical detection will be developed. Samples prepared using CELL-O-MATIC technology will be benchmarked in a high throughput environment with samples prepared by existing methods. Finally, the information obtained from the CELL-O-MATIC processed sample material will be validated for its utility as an aid to clinical decision making.","High Throughput Systematic Single Cell Genomics using Micro/Nano-Fluidic Chips for Extracting, Pre-analysing, Selecting and Preparing Sequence-ready DNA",FP7,31 December 2015,01 January 2012,5998788.0 CELLADHESIVENANOKEYS,Heidelberg University * Ruprecht-Karls-Universität Heidelberg,health,"Cell-cell and cell-extracellular matrix (ECM) adhesion are complex, highly regulated processes that play a crucial role in most fundamental cellular functions including motility, proliferation, differentiation and apoptosis. Focal adhesions are major cellular sites responsible for cell-ECM attachment and adhesion-mediated signalling. These complex multimolecular assemblies consist of transmembrane integrin receptors that are linked to the actin cytoskeleton via cytoplasmic anchor proteins, such as vinculin, paxillin and focal adhesion kinase. To study the function behind molecular arrangement of single integrins in cell adhesion, we will design rigid template of cell adhesive gold nano-dots coated with cyclic RGDfK peptide by lithographic means of diblock copolymer self-assembly. The diameter of the adhesive dots is smaller 8 nm, which allows the binding of only up to one integrin per dot. These dots are positioned with high precision on a molecular scale at a controllable separation distance between 10-150 nm in different but defined pattern geometries. Because the dots may only be occupied by up to one integrin the dot pattern also resembles the integrin pattern in focal adhesions. We will study how the chemical nanoadhesive template effects cell spreading and shape, adhesion forces and expression of Fibronectin and Collagen.",Designing nanoadhesive keys to manipulate cell adhesion and signalling,FP6,31 December 2006,01 August 2005,161599.76 CELLCONTROL,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"The newly emerging discipline of Synthetic Biology holds the promise of radically changing the way we probe, control and augment living matter from single cells to entire organisms, and revolutionize basic biological research, biotechnology, and medicine. However, practical work toward these important goals is still in its infancy, in part because concrete approaches to achieve rational control of cell physiology are currently lacking. In order to advance this vision, here we propose a detailed strategy toward engineered regulatory circuits that read out complex cellular states based on multiple biological signals, and convert this information into a desired action based on pre-programmed signal integration. If successful, our strategy will enable unprecedented level of rational intervention with the cell. Specifically, we suggest to read out cellular information as relayed by expression and activity of cell's transcription factors, proteins that control gene expression and serve as major regulators of cell fate and cell response to transient stimuli. The readout will be accomplished with the help of specially-designed sensor promoters that will in turn drive the expression of engineered microRNA molecules. Those molecules in turn will converge on a small number of response elements in engineered downstream transcripts, implementing highly-flexible and programmable logic integration of the original transcription factor signals (Rinaudo et al, Nature Biotechnology, 2007 and Leisner et al, Nature Nanotechnology, 2010). We propose a stepwise bottom-up construction strategy whereby we first design, test and optimize sensor promoters for individual TFs, next we integrate them into large networks, and finally we show how to utilize these networks as prototype selective anti-cancer therapies. To validate our approaches, we will use human cancer cell lines as a model system.",Synthetic regulatory circuits for programmable control of cell physiology,FP7,30 September 2016,01 October 2011,1479008.0 CELLFORCE,Swiss Federal Laboratories for Materials Science and Technology * Eidgenössische Materialprüfungs- und Forschungsanstalt,health,"Characterisation of cells is of crucial importance in various fields of health care. Since many biological processes are characterized by the sequential appearance of certain cell constituents that are present only during a short period of time statements based by taking only one time point into account are tainted with errors. The present goal is the development of a complete new concept and its implementation for nanotechnology biosensor-based integrated systems for health. The long-term objective of the present project is the development of a new medical instrument and/or intelligent diagnosis equipment for healthcare of the future, using advanced biological biosensors. It is based on the integration of technological developments regarding precision engineering, optical and computational methods. The sensor will result in a quantum leap regarding knowledge of the interactions between biological and non-biological systems. The biosensor that will be developed, is based on the on-line monitoring of traction forces that each cells transduce to surfaces through their with the cytoskeleton connected focal adhesion points (FA), being the connecting points between the cell and the material surface. The obtained biosensor can find its application in various fields of health care from characterising specific cells of the patient to optimise the treatment, as biosensor to detect the presence of bioactive medium components having a pharmacological or toxic effect on cells, as a completely new biological tool to describe and investigate time dependent biological processes (fundamental research in the direction of pharma/toxicodynamics, drug effects, effects of gene defects, in combinations with transfected cells genomics, time evolution of subcellular processes, etc., etc.).",Development of a single cell based biosensor for subcellular on-line monitoring of cell performance for diagnosis and healthcare,FP6,30 June 2009,01 November 2005,1863000.0 CELLION,PAN - Henryk Niewodniczański Institute of Nuclear Physics * Henryk Niewodniczański Institute of Nuclear Physics,health,"Our understanding of the biological effects of radiation exposure is still far from complete in spite of a tremendous progress in recent years, whilst any estimation of radiation hazards requires profound knowledge on interaction of ions with biological cells and tissue.
In particular, there is a still unresolved debate about the action of exposure to very low dose radiation, which is presently only estimated by high dose data extrapolation. If low dose effects are studied by irradiating a cell culture by a conventional broad ion beam, only some few cells are hit. As in a control culture some cells always die spontaneously, the result is of low statistical value.
Therefore, some laboratories have introduced successfully the use of collimated ion beams, by which cells can be individually irradiated with a given ions number. Such exact knowledge of hit and non-hit cells enables also studies of the radiation damage transfer from hit to bystander cells, a so called "bystander effect".
From the use of focused microbeams we expect better definition of LET, greater range of LET in case of heavy ion beams, and higher aiming accuracy. New achievements in nanotechnology permit us to construct an intelligent wet cell chamber, where in addition to the late radiation effects, also signals emitted by cells during (and shortly after) irradiation will be studied.
Therefore, we are creating a network of dedicated microprobes delivering individually counted ions to precise cellular locations. The project requires a close collaboration within mixed teams of specialists in biology, biophysics, oncology, nanotechnology, accelerator physics and solid state physics. Biological effects of ion irradiation will be studied as a function of (i) energy and atomic number of primary ions, (ii) ion track location within the cell, (iii) number of tracks, (iv) cell species, (v) cell state (cell cycle, functional status). Using standard bio-medical assays and new nanobiosensors we",Studies of cellular response to targeted single ions using nanotechnology,FP6,31 January 2008,01 February 2004,2745560.0 CELLMECH,Technion Israel Institute of Technology,health,"I seek to understand the molecular origin of cell mechanosensing - the ability of biological cells to sense and respond to the mechanical properties of their environment. Moreover, I want to explore the possibility that propagation of mechanical deformation within soft biomaterials can act as a communication route between neighboring cells. A long term goal is to guide injured axons to establish reconnection with the proper target by directing the axon towards the mechanical deformations generated by the target cell. 'Cell mechanosensing' raises some basic science questions, part of which can only be solved by an interdisciplinary-multi-scale approach, combining concepts from macroscopic approaches - such as elasticity theory and rheology - with a molecular point of view, taking into account the intricate interplay of chemical and physical processes. We will use a unique combination of high resolution optical microscopy, single molecule imaging, magnetic tweezers, biomaterial design and characterization, numerical algorithms and theoretical modeling. In particular, our aims include: 1. Characterization of the force generated by neuronal growth cone and its frequency, before and following injury. 2.Developing new engineered protein biomaterials with mechano-sensitive properties and a well defined dynamic viscoelastic profile which are able to support neuronal cell growth. These include biomaterials which: a) Change their fluorescence properties in response to small material deformations in the nanometer range. b) Efficiently propagate and amplify growth-cone-generated mechanical deformations to allow for cell-cell communication. An essential part of this project is studying the dependence of the viscoelastic spectrum of the network on the mechanical properties of the single chain. 3. Identifying the feedback mechanism that enables the cell to regulate its intrinsic elasticity and the forces it applies in response to the mechanical properties of the substrate.",Molecular-Physical Basis of Cell-Biomaterial Mechanical Coupling,FP7,31 March 2016,01 April 2012,100000.0 CELLMECHANOCONTROL,Georg August University of Göttingen * Georg-August-Universität Göttingen,health,"Biological cells possess a chemical 'sense of smell' and a physical 'sense of touch'. Structure, dynamics, development, differentiation and even apoptosis of cells are guided by physical stimuli feeding into a regulatory network integrating biochemical and mechanical signals. Cells are equipped with both, force-generating structures, and stress sensors including force-sensitive structural proteins or mechanosensitive ion channels. Pathways from force sensing to structural and transcriptional controls are not yet understood. The goal of the proposed interdisciplinary project is to quantitatively establish such pathways, connecting the statistical physics and the mechanics to the biochemistry. We will measure and model the complex non-equilibrium mechanical structures in cells, and we will study how external and cell-generated forces activate sensory processes that (i) act (back) on the morphology of the cell structures, and (ii) lead to cell-fate decisions, such as differentiation. The most prominent stress-bearing and -generating structures in cells are actin/myosin based, and the most prominent mechanoactive and -sensitive cell types are fibroblasts in connective tissue and myocytes in muscle. We will first focus on actin/myosin bundles in fibroblasts and in sarcomeres in developing heart muscle cells. We will observe cells under the influence of exactly controlled external stresses. Forces on suspended single cells or cell clusters will be exerted by laser trapping and sensitively detected by laser interferometry. We furthermore will monitor mechanically triggered transcriptional regulation by detecting mRNA in the nucleus of mouse stem cells differentiating to cardiomyocytes. We will develop fluorescent mRNA sensors that can be imaged in cells, based on near-IR fluorescent single-walled carbon nanotubes. Understanding mechanical cell regulation has far-ranging relevance for fundamental cell biophysics, developmental biology and for human health.",The physical basis of cellular mechanochemical control circuits,FP7,31 May 2019,01 June 2014,2425200.0 CELLNAC,Heidelberg University * Ruprecht-Karls-Universität Heidelberg,health,"The development of new methodologies in the field of material science and nanotechnology represents a useful tool to further explore and modify biomaterial design. Biocompatiblity is dependent on material-related factors,such as topography and surface chemistry, as well as cell adhesion and function. The focus of this multidisciplinary work is the creation of a system, which permits the study of bone cells adhesion and the regulation of their cellular activities. We propose to use novel chemical techniques to mimic the extracellular environment with bioactive peptides arranged into a rigid well defined nano-template. We reason that these peptides should control cell attachment and activate integrin-dependent intracellular signaling pathways for bone cell proliferation, differentiation and death by apoptosis.The fellow will gain experience in material science, biophysical chemistry, biophysics, cell biology, and clinical research. The scientific and educational activity will be also embedded in a high quality research and education environment established at the Heidelberg University. Because of her past research experience, the candidate fits excellently to the named project where multidisciplinary skills and knowledge are needed. She will combine her abilities with the abilities of the group of Biophysical Chemistry at the University of Heidelberg, whose main focus is the control of cell adhesion by biophysics and nanotechnology. Until the end of the Marie Curie Fellowship in 2005 she will have the chance to gain enough qualifications to become an associated faculty member in an European Institute or University.The European Community is investing into a young researcher which will have great potential to connect European research activities in future years. Thus, her will for worldwide mobility is enhancing her own scientific excellence which than will be carried forward to other young scientists and research institutions in Europe.",Modulation of osteoblast function by bioactive RGD-peptides arranged in nanotemplates,FP6,31 March 2006,01 April 2004,160466.0 CELLNANOTOX,Tel Aviv University,environment,"The present proposal aims at the development of innovative multidisciplinary sets of tests and indicators for toxicological profiling of nanoparticles (NPs) as well as unravelling the correlation between the physicochemical characteristics of NPs and their toxic potential on various organs of the human body. For a comprehensive understanding of the complex data to be obtained on toxicology of NPs, based on in-vitro and ex-vivo studies, we will employ conventional toxicology combined with the methodologies of toxicogenomics, metabonomics, Knowledge Discovery from Data (KDD) and Data Mining (DM). This research program is focused towards understanding the relation of size and surface chemistry on the deposition, uptake, translocation, and toxicity of a few selected industrially important NPs as well as novel synthesized NPs, whose size and surface chemistry will be methodically modified. Since it was shown that the penetration of NPs into the human body proceeds principally through inhalation or orally, whereas penetration through healthy skin is restricted, we have chosen lung and intestine as the primary interacting tissues/organs with NPs, while liver, kidney and the immunological system have been selected to be the secondary major sites of interaction, following the penetration of NPs into the blood circulation. The interaction of the NPs with these different target organs will be studied by making use of alternative methods to animal experimentation by employing in-vitro cell systems as well as ex-vivo studies based on precision-cut slices of lung, liver and kidney. The present proposal addresses the needs of the European society for assessing the risk of occupational and general population exposure to industrially manufactured NPs. It will generate new knowledge on potential health risk or the absence of it, providing objective arguments for recommendations and regulations.",Cellular Interaction and Toxicology with Engineered Nanoparticles,FP6,30 April 2010,01 November 2006,2600000.0 CELLO,Curie Institute * Institut Curie,health,"We shall develop a microfluidic and microsystems toolbox allowing the construction and study of complex cellular assemblies ('tissue or organ mimics on chip'), in a highly controlled and parallelized way. This platform will allow the selection of specific cells from one or several populations, their deterministic positioning and/or connection relative to each other, yielding functional assemblies with a degree of complexity, determinism and physiological realism unavailable to current in vitro systems We shall in particular develop 'semi-3D' architectures, reproducing the local 3D arrangement of tissues, but presenting at mesoscale a planar and periodic arrangement facilitating high resolution stimulation and recording. This will provide biologists and clinicians with new experimental models able to bridge the gap between current in vitro systems, in which cells can be observed in parallel at high resolution, but lack the highly ordered architecture present in living systems, and in vivo models, in which observation and stimulation means are more limited. This development will follow a functional approach, and gather competences and concepts from micr-nano-systems, surface science, hydrodynamics, soft matter and biology. We shall validate it on three specific applications, the sorting and study of circulating tumour cells for understanding metastases, the creation of 'miniguts', artificial intestinal tissue, for applications in developmental biology and cancerogenesis, and the in vitro construction of active and connected neuron arrays, for studying the molecular mechanisms of Alzheimer, and signal processing by neuron networks. This platform will also open new routes for drug testing, replacing animal models and reducing the health and economic risk of clinical tests, developmental biology, stem cells research. and regenerative medicine.",From Cells to Organs on Chips: Development of an Integrative Microfluidic Platform,FP7,30 June 2018,01 July 2013,2260000.0 CELLPROM,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"We will develop a new generation of nano-biotechnological equipment, the CellPROMs. As the EPROM paved the way to a broad application of microelectronics, CellPROMs will overcome current limits of and revolutionise the existing handling technologies and procedures by automated, compact and parallel yet still individual handling of large numbers of cellular samples. Typical targets will be animal and human adult stem cells. Human embryonic stem cells will not be used. The main task of our IP is to develop procedures and devices for the precise creation of NanoScapes - individually tailored nanoscaled macromolecular landscapes which will allow, for the first time, to non-invasively produce well-defined populations of individually programmed cells, eventually leading to substantial breakthroughs and numerous applications in the fields of molecular medicine and cellular nano-biotechnology. Although surface imprinting of cells will be realised via artificial nano-biotechnological devices, e.g. nanostructured stamps or beads, these tools are designed according to the natural principles of cellular signalling and differentiation. As nanocomponents are essential to the imprinting process, suitable techniques and principles to form nanoscaled macromolecular patterns on arbitrary surface geometries have to be developed. All components, ranging from the nanoscale of functional interfaces up to the macro level for cell handling, are to be developed as functional modules suitable for further application. The project features multiple nano- and biotechnological challenges. To tackle these, will lead to breakthroughs in nanotechnological device development and, moreover, drastically advance our understanding of biological signals relevant to cellular programming. Once available, CellPROMs will facilitate the transition to a more knowledge-based and less resource-intensive society in Europe.",CellPROM - Cell Programming by Nanoscaled Devices,FP6,29 February 2008,01 March 2004,1.7599928E7 CELLSTATETRANSITIONS,University of Cambridge,health,"During early mouse embryogenesis the cells of the blastocyst's inner cell mass take a lineage decision to contribute either to the epiblast or the primitive endoderm (PE). The allocation of cells to either lineage depends on the activity of FGF signaling and two gene regulatory networks (GRNs), one centered on the transcription factor Nanog, the other one relying on Gata factors. The two GRNs are initially activated in an overlapping and heterogeneous pattern in the ICM, and have been proposed to compete each other out over time. The dynamics of this competition, and how the transition state between the two lineages, marked by co-expression Gatas and Nanog, is resolved, is not known. Here I propose to address these questions in vitro by recapitulating the competition between the Gata- and Nanog-GRNs through the controlled overexpression of Gata factors. This converts embryonic stem cells (ESCs), which contribute primarily to the epiblast when introduced in chimeras, into extraembryonic endoderm (XEN) cells, which contribute solely to PE derivatives. I will combine fluorescent reporters with this ES-to-XEN transition to ask with which dynamics transitions occur in individual cells, whether they involve heterogeneities at the population level, and how these parameters are controlled by the activity of gene regulatory networks and signaling pathways. I will aim at identifying culture conditions that stabilize the transition state, where cells might be on the brink of being XEN, and therefore akin to ICM. I hypothesize, that under these conditions cells will be endowed with higher developmental potential compared to parental ES cells, and be able to contribute to both epiblast and PE-derived tissues. The results of this project will enhance our understanding of the mechanisms underlying lineage decisions in early development and may uncover more general principles that govern the way in which differentiating cells are specified in a stem cell pool.",Capturing transition states associated with lineage decisions in the early mouse embryo,FP7,31 December 2014,01 January 2013,209033.0 CELLUFUEL,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,energy,Biofuel from wood and waste will be a substantial share of our future energy mix. The conversion of lignocellulose to fermentable polysaccharides is the current bottleneck. We propose to use single molecule cut and paste technology to assemble designer cellulosoms and combine enzymes from different species with nanocatalysts.,Designer Cellulosomes by Single Molecule Cut & Paste,FP7,28 February 2017,01 March 2012,2351450.0 CELLULOSOMEPLUS,Consejo Superior De Investigaciones Científicas (CSIC),energy,"The major bottleneck for plant biomass processing is fiber saccharification: the conversion of cell wall lignocellulosic biomass into fermentable sugars (en route to production of value-added chemicals like second generation biofuels). Some microbes enhance this step by using natural self-assembling proteinaceous nanocatalists known as cellulosomes. CellulosomePlus targets rational design of optimized cellulosomes to overcome this problem.This would allow efficient production of biofuels from low-value raw materials like inedible parts of plants and industrial residues (which are all renewable, sustainable and inexpensive). First we propose to characterize the physicochemical and structural properties (including mechanostability) as well as interactions of enzymes and scaffolds from natural cellulosomes and non-cellulosomal components. In parallel, we will characterize a suitable residual substrate from municipal waste (organic fraction of municipal solid waste) and develop improved assays to reliably follow cellulosomal enzymatic activity. The acquired knowledge will be complemented with rapid computational modelling at the atomic and supramolecular levels for testing and predictions. Experimental and theoretical knowledge will be then integrated to design improved cellulosomes (with high-selectivity, activity and cost-effectiveness). Further improvement will be obtained by iteration using high throughput screening of components. The improved cellulosomes generated through this innovative multidisciplinary approach represent a step towards green chemistry since they are biodegradable proteinaceous materials and therefore by-products and/or wastes are minimized due to the high enzymatic selectivity. Finally, the production of the optimized cellulosomes (and the process involved) will be scaled up to preindustrial scale to demonstrate their viable commercial production. These results will be patented and a roadmap will be drawn up towards future standardization.",Boosting Lignocellulose Biomass Deconstruction with Designer Cellulosomes for Industrial Applications,FP7,31 October 2017,01 November 2013,3997019.0 CELNAPAG,University of Cambridge,health,"The proposed project will develop and apply new theoretical and computational methodologies to study (bio)polymers and (bio)polymer aggregates. The techniques involved focus upon the underlying potential energy landscape and use global optimisation to locate low-lying minima, and calculation of thermodynamic and dynamic properties using databases of stationary points. Polymer energy landscapes are especially difficult to treat using conventional methods (e.g. molecular dynamics, Monte Carlo) as they feature vast numbers of local minima, broken ergodicity, and long relaxation times compared to those accessible by standard simulations. Broken ergodicity and slow relaxation issues are caused by experimentally relevant regions of configuration space being separated by high energy barriers, which although overcome on experimental time scales, are difficult to treat in simulations. The proposal would extend and generalise methods developed in the host group, which have been successfully applied to clusters and peptides. The manifestation of the topology of the potential energy surface in observable dynamic/thermodynamic properties will be elucidated for polymer chains with various architectures (linear, ring, comb, dendrites) and for nano-aggregates of multiple chains. Aggregation of misfolded peptides is particularly important due to the implication of such structures in a growing variety of debilitating human diseases. There is an urgent need to understand such processes in more detail, especially the underlying generic structural principles. The host group has internationally recognised expertise, having introduced or developed many of the above methods. New developments in theory and software will be made available to other workers in the synthetic and biopolymer fields by publication in peer-reviewed journals. Treatment of larger systems, especially aggregates will require parallelisation of existing codes, and may use existing and future grid computing technology.",Characterising the Energy Landscape of Nano-Polymer-Aggregates:Application to Synthetic and Bio-polymers,FP6,28 February 2007,01 March 2005,158480.0 CEMAS,IBM Research GmbH,information and communications technology,"The objective of this project is to advance and use Atomic Force Microscopy (AFM) to explore the physical and chemical properties of single molecules and molecular systems with unprecedented spatial resolution. We will use AFM to develop atomically resolved molecular imaging with structural and chemical identification and investigate charge distribution and transfer in molecular systems. The AFM will allow the extension of seminal Scanning Tunneling Microscopy (STM) work on atoms/molecules on ultra-thin insulating films to thick insulating films, to control and explore single molecule chemistry processes in utmost detail. The whole work will be significantly based on the development and exploitation of novel atomic and molecular manipulation processes to control matter at the atomic scale, both for fabricating novel complex molecular nanostructures with atomic scale precision and understanding these systems, as well as for probe-tip functionalization to tailor tip-substrate interaction. Instrumental enhancements will focus on fabricating novel AFM sensors for simultaneous lateral and vertical force measurement and on developing a new original approach to increase the time resolution in AFM measurements. Due to the fundamental nature of this work we expect the long term impact of this work to be in surface science, chemistry, molecular electronics and life sciences. In the short term we expect to develop the AFM into a practical tool for chemical structure determination of unknown molecules and we will employ atomic manipulation and high resolution AFM imaging to image, modify and functionalize graphene edge structures with atomic scale precision with the prospect of exploring and developing novel molecular devices.",Controlling and Exploring Molecular Systems at the Atomic Scale with Atomic Force Microscopy,FP7,11 June 2018,12 January 2011,2496720.0 CERAMPOL,Acondicionamiento Tarrasense Associacion,health,"The main objective of the CERAMPOL project is to achieve a new generation of smart and low-fouling nanostructured membranes based on ceramic and polymeric materials with enhanced affinity to heavy metals and drugs. CERAMPOL will contribute in solving issues related to waste water in metallurgic and pharmaceutical industries/hospital respectively. Moreover, by reducing the concentration of highly toxic contaminants in the water supplies, lakes, rivers, and streams, the new filtration technology developed in the CERAMPOL project will mitigate the risk to humans' health and the environment such as bioaccumulation of heavy metals, the emergence of multidrug resistance organisms, chronic toxicity, and metal-related diseases. The new filters will be prepared by innovative processes such as electrospinning, sol-gel, coating processes for obtaining multi-layered membranes possessing several key properties such as: antifouling; self-cleaning; selective filtration of antibiotics and heavy metals. Specifically, the multi-layered membranes will composed of three functional parts CERAMPOL functional parts: an anti-fouling pre-filter based on polymeric nanofibers, a cleaning system based on piezoelectric materials, and a highly selective nanostructured ceramic membrane. The new filters will be scaled up at semi industrial level for in-situ water treatments in foundry, pharmaceutical and hospital effluents. The benefits of such technology will be fully characterized in terms of water filtration efficiency and economic and environmental impacts. Complete technological and economical viability assessments of the CERAMPOL technology will be carried out by the industrial partners. Environmental impact caused by the new filtration technology will be fully assessed in order to highlight benefits in terms of water preservation and recovering.",CERAMIC AND POLYMERIC MEMBRANE FOR WATER PURIFICATION OF HEAVY METAL AND HAZARDOUS ORGANIC COMPOUND,FP7,31 January 2016,01 February 2012,3463889.0 CERAWATER,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,environment,"The main challenge of the proposed project is the development of a ceramic honeycomb nanofiltration membrane with strongly increased membrane area of up to 25 m². The strongly increased membrane area in comparison with existing ceramic membranes for nanofiltration in combination with a high surface to volume ratio shall be competitive with polymeric membranes in terms of economics. The nanofiltration coating will allow for instance the direct filtration of surface water for drinking water preparation by a “low volume, low energy” filtration process. The low fouling tendency of the ceramic material will lead to low operating costs and reduced membrane down time during membrane cleaning. The high mechanical stability enables high pressure back-flushing of the membranes. The high chemical and thermal stability of the membrane material allows the chemical or thermal regeneration and sterilization by aggressive chemicals or hot steam if needed. Furthermore ceramic membranes shows considerably higher permeate fluxes in comparison to polymeric membranes. In addition to the high permeability and a low fouling tendency the membranes can be operated at low transmembrane pressures and low cross flow velocities. This strategy helps to reduce operation costs and save energy (“low feed, low pressure”).",Fouling resistant ceramic honeycomb nanofilters for efficient water treatment,FP7,01 July 2017,02 January 2012,0.0 CERMAT2,University of Trento * Università degli Studi di Trento,environment,"The CERMAT2 project is aimed to train young researchers in understanding the modelling of Solid Mechanics problems applied to the process and design of advanced ceramics in a synergic collaboration between academia and industry, in view of social developments related to enhancement of industrial production and pollution reduction.",New ceramic technologies and novel multifunctional ceramic devices and structures,FP7,10 July 2019,11 January 2013,0.0 CHALQD,International Iberian Nanotechnology Laboratory * Laboratorio Ibérico Internacional de Nanotecnología,energy,"Solar cells based on today's technology are limited to power conversion efficiency around 30%. To achieve mass deployment of photovoltaic systems there is the need to lower the actual production costs and one way to do so is to produce solar cells with very high efficiencies. Intermediate band solar cells are, in theory, limited to efficiencies as high as 60% and they can be prepared by incorporating quantum dots in a matrix material. The purpose of this proposal is to prepare intermediate band solar cells based in quantum dots of chalcopyrite materials. Chalcopyrites were chosen because they are known to have good optoelectronic and material properties as demonstrated by their performance when used in thin film solar cells. Solar cells based in chalcopyrites exhibit the highest performance of all the thin film solar cells. To achieve this proposed aim the project is structured in three objectives. The first one is the preparation of chalcopyrite quantum dots using molecular beam epitaxy, the second one deals with the choice and growth of a suitable matrix material and the last one consists in bringing these two parts together and creating a solar cell stack. The candidate has a sound experience in chalcopyrite thin film solar cells and will be trained in the cross-disciplinary areas of preparation, characterization, and theory of nanostructures based in quantum dots. The main objectives are therefore: (1) Development of controlled growth of chalcopyrite-type QDs, and tuning their optoelectronic properties for suitable application in photovoltaic energy conversion (2) Development of a suitable matrix material (3) Tuning the properties of the interface between QDs and matrix to provide the basis for efficient photovoltaic energy conversion. A successful outcome will make significant progress in the knowledge of very high efficiency photovoltaic.",Chalcopyrite Quantum dots for Intermediate band Solar cells,FP7,31 March 2015,01 April 2013,147210.0 CHEMABEL,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"The renewable energy technologies already available are not yet capable of competing with fossil fuels mainly due to a poor ratio cost/efficiency. A clear example is photovoltaic energy, for which high costs and moderate performances yield too long payback times, despite the huge amount of solar energy constantly reaching the Earth. The key to cheap and more efficient renewable energy sources lies in the materials at the heart of the different technologies. The synthesis of novel materials with superior tailored properties for each particular energy application, and the development of cheap and scalable fabrication protocols is therefore crucial if renewable energy technologies are to take a main share of modern society energy mix. Thus I plan to focus on the synthesis and study of novel materials based on earth abundant elements, with tailored properties for application in photovoltaic cells and other electronic devices, such as transparent electronics. On a complementary research line, the design of simpler and more efficient cell (nano)architectures is another key factor in maximizing the efficiency/cost ration of solar cells. In this sense I intend to develop novel nanoarchitectures in which the two main processes in solar cells, namely light abslorption and charge extraction, are decoupled and thus can be separately tackled and optimized. I want to address these goals by using and developing facile, low-cost and scalable approaches. The hydrothermal method has proven to be a very effective synthetic approach yielding both known and new phases. Moreover, it is a low cost method and easily scalable. I have also shown the efficiency of hydrothermal reactions for the fabrication of hybrid nanostructures. Additionally, other low-cost, solution-based methods will be explored (electrochemistry, chemical oxidation, etc). Finally, an exciting new approach to Atomic Layer Deposition that operates at atmospheric pressure will be developed and implemented.",Low-temperature CHEMical approaches to novel materials based on earth ABundant ELements. Towards advanced electronic and optoelectronic applications,FP7,28 February 2018,01 March 2014,100000.0 CHEMAPH,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"Chalcogenide-based phase change materials (which contain at least one element from Group VI in the periodic table: Te, Se,or S) have recently generated strong attention for electronic memory applications, due to their success as optical storage media. Phase-change memories (PCM) are one of the most promising candidates for next-generation non-volatile memories, having the potential to improve the performance compared to Flash memories as well as to be scalable beyond Flash technology. One technological issue is the phase-change layer deposition process, which principally determines the implementation of the material properties. Phase-change films are currently grown by sputtering, a physical vapor deposition technique, which has yielded demonstrator chips. However, for continued down-scaling for high-density nanoelectronic devices and lower programming currents, greater control of film deposition over non-planar structures is than possible with sputtering is necessary. Despite this need, no other deposition routes are available nor widely studied. Overall Objectives The project therefore aims at the development of a film manufacturing process based on a chemical-based technique, metal-organic chemical vapor deposition (MOCVD). MOCVD enables the production of thin films with superior quality compared to those obtained by sputtering, especially in terms of conformality, coverage, and stoichiometry control, and allows implementation of phase-change films in nanoelectronic devices. The main phase-change chalcogenide material system that will be investigated is Ge2Sb2Te5 (GST). Once a suitable process is developed, it will be used to fabricate state-of-the-art memory cells at the 90/65 nm node, and the electrical performance compared with standard devices based on sputtered GST. Doping of GST and modified compounds will also be investigated to improve device performance.",Chemical Vapor Deposition Of Chalcogenide Materials For Phase-Change Memories,FP6,30 November 2008,30 December 2005,1989999.92 CHEMCELL,University of York,health,"The programme of training seeks to provide an ideal environment for young scientists to gain experience in aspects of chemistry and the life sciences that relate to major problems facing Chemical Biology in the post-genomic era. With the completion of the human genome sequence our understanding of the molecular basis of disease and causative factors is set to increase enormously. Two major challenges for Chemical Biology in this post genomics era will be: 1. To meet the increasing demand for novel, relevant, biologically active compounds that can be used as drugs; 2. To deliver sensitive and quantitative extraction and detection methodologies for the high-throughput analysis of proteins and small molecules in research programmes aimed at determining the function of genes and the composition of the food we eat. The programme of research seeks to target two different classes of compounds important for health -therapeutics and health-promotors. It aims to develop a range of novel generic methodologies for the study of these two classes of compounds. Novel nanoscale separations materials will be produced, housed in capillary-borne microreactors linked with CCD imaging and mass spectrometry to permit real-time monitoring of the success of immobilised enzymes in therapeutic biotransformations. These same materials will be used to develop novel high-throughput separation methodologies for the analysis of different classes of health-promoting compounds extracted from plants. Together with genomic data, these analyses will enable a more complete elucidation of how the production of health-promoting compounds in plants is regulated. The programme depends on the multi-disciplinary input of analytical scientists, green chemists, plant biologists and biotechnologists and offers a unique training at the boundary between disciplines.",Chemical Biology in Reactors and Cells,FP6,30 June 2008,01 July 2004,1246004.0 CHEMHEAT,University of Copenhagen * Københavns Universitet,energy,"Nanoscale systems binding single molecules, or small numbers of molecules, in conducting junctions show considerable promise for a range of technological applications, from photovoltaics to rectifiers to sensors. These environments differ significantly from the traditional domain of chemical studies involving molecules in solution and the gas phase, necessitating renewed efforts to understand the physical properties of these systems. The objective of this proposal concerns one particular class of physical processes: understanding and controlling local heating in molecular junctions in terms of excitation, dissipation and transfer. Local heating and dissipation in molecular junctions has long been a concern due to the possibly detrimental impact on device stability and function. More recently there has been increased interest, as these processes underlie both spectroscopic techniques and potential technological applications. Together these issues make an investigation of ways to chemically control local heating in molecular junctions timely and important. The proposal objective will be addressed through the investigation of three challenges: - Developing chemical control of local heating in molecular junctions. - Developing chemical control of heat dissipation in molecular junctions. - Design of optimal thermoelectric materials. These three challenges constitute distinct, yet complementary, avenues for investigation with progress in each area supporting the other two. All three challenges build on existing theoretical methods, with the important shift of focus to methods to achieve chemical control. The combination of state-of-the-art computational methods with careful chemical studies promises significant new developments for the area.",Chemical Control of Heating and Cooling in Molecular Junctions: Optimizing Function and Stability,FP7,30 November 2015,01 December 2010,1499999.0 CHEMTRONICS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),photonics,"This EST proposal aims at addressing the ultimate issue of the necessary multidisciplinary training at the interface between the most advanced scientific research and the pre-industrial research in the 'chemistry and nanoelectronics' domain. This training project based on recruitment of more than 15 PhD students, in the frame of the MINATEC innovation center, will allow a better coupling efficiency both between chemistry and nanoelectronics and between scientific and technological research. It will favour a multicultural approach so that experts, researchers, engineers and students can run or take part to multidisciplinary projects which are crucial for the future of nanoelectronics. This project will be the first main step of a long term academical and technological training and development program. Molecular electronics and supramolecular electronics are ones of the foreseen futures of today’s microelectronics through the use of bottom-up approaches. Embryonic research is of critical importance to keep and attract the knowledge in Europe and to avoid “brain leakageâ€. Grenoble-MINATEC beeing already one of the main successful European “ecozones†is able to compete with the famous Silicon Valley. This EST project is submitted by the French Atomic Energy Commission (CEA). Its laboratories are located in Paris (Saclay) and Grenoble, the two major French scientific poles, and gather 2800 researchers of whom 140 are specifically involved in the advanced and recent 'chemistry and nanoelectronics' program on molecular electronics, polymer electronics, nanophotonics, surface and supramolecular chemistry together with the leading technological platform of LETI-MINATEC. Such a program within a single institution is unique and it has an original and unique specificity: the formation of top-level multidisciplinary researchers with a truly double scientific and technological culture.",Chemistry and Nanoelectronics,FP6,28 February 2010,01 March 2006,1675511.97 CHEMWATER,DECHEMA Gesellschaft für Chemische Technik und Biotechnologie eV,environment,"Europe must use water more efficiently to avoid the anticipated impacts of water shortage driven by a range of dynamics incl. climate change. Nanotechnologies, materials and process innovations (NMP) are key enabling technologies for efficient industrial water management. The chemical industry has a unique role as major water user AND a key solution provider for the development of future water technologies.","Coordinating European Strategies on Sustainable Materials, Processes and Emerging Technologies Development in Chemical Process and Water Industry across Technology Platforms",FP7,10 July 2015,05 January 2011,0.0 CHESS,Polytechnic Institute of Bordeaux * Institut Polytechnique de Bordeaux,energy,"This IEF project aims to address both hurdles apparent in the fabrication of Bulk Heterojunction Organic Photovoltaics (OPVs), i.e. the tailoring of the domain size to be close to the excitonic diffusion length and the stability of the blend morphology, through a wise incorporation of block copolymers in the blend that forms the active layer of OPVs. My target is to fabricate highly efficient solar cells with enhanced morphological stability and prolonged lifetimes, applying process techniques that can be easily adopted by industry. The self-assembly properties of block copolymers as well as their ability to form well controlled nanostructures and to act as compatibilizers in the blends of the respective homopolymers will be exploited to form stable nanomorphologies with optimum domain size, according to the specifications required for OPV applications. An integrated study will be conducted, starting from fundamental research on the polymer physics of the ternary system: rod-like homopolymer A -homopolymer B -rod-coil copolymer A-B. Next, the blends which exhibit the desirable co-continuous morphological characteristics will be incorporated into OPVs and the device performance and stability will be studied and optimized. Finally, I am going to apply the concepts of graphoepitaxy, a novel technique applied for the fabrication of well-ordered arrays of block copolymers, in the construction of OPVs, in an effort to realize the ideal interpenetrating structure proposed and achieve even higher efficiencies through a precise control of the nanostructure. The scope of the proposed research lies on the cutting-edge field of organic electronics (OE), which is of strategic importance for the competitiveness and the advancement of the socio-economic conditions of the European Union. The skills acquired during my studies will be complemented by the extensive experience of the host institute on OE to assure a successful accomplishment of this fully interdisciplinary project.",Block Copolymers for High Efficient Solar Cells with novel Structures,FP7,31 March 2014,01 April 2012,193594.0 CHILTURPOL2,Ege University * Ege Üniversitesi,environment,"WHO reports annular death of 5 million people caused by the use of contaminated water. To reduce this number more effective purification technologies and grow of ecological consciousness should be introduced. Both of them are considered in the project by the following objectives: to bring together some international research teams,",Innovative materials and methods for water treatment,FP7,05 July 2016,06 January 2011,0.0 CHIMERA,University of Tartu * Tartu Ülikool,health,"The overriding goal of this project is to mimic Nature in the design of novel nucleic acid/peptide chimera based nanodevices that can enable cancer imaging. We will design, engineer and optimize highly specific biomolecular nanodevices that undergo binding-induced conformational changes upon target binding and, in doing so, signal the presence of the cancer marker. This scientific goal of great relevance for the clinical implications will be achieved bringing together an international and interdisciplinary group of research teams and building a collaborative environment for research, innovation and technology transfer. This program will allow the exchange of knowledge and expertise through visiting training periods for participating early-stage and experienced researchers. The training will involve each single aspect of probe development and cancer imaging. The research teams involved in this project encompass the requisite expertise and each of them has a particular focus on a single step of optical probe development and testing on cancer cells. This program will help the integration and collaboration among the research teams and the establishment of a long-term collaboration between Europe and key Third Countries.",Binding-activated fluorescent DNA/peptide chimeric probes for cancer imaging,FP7,31 October 2016,01 November 2013,119700.0 CHIPCAT,Charles University * Univerzita Karlova v Praze,energy,"chipCAT aims at the knowledge-driven development of a novel type of thin-film catalysts for silicon-based 'on-chip' micro fuel cells (u-FCs). Combining fundamental surface-science, model catalysis, and first-principles computational studies, a detailed understanding of the surface chemistry on complex nanostructured catalysts will be achieved. This microscopic-level understanding will be used to tailor active sites and their mutual interplay at the nanoscale in order to maximize activity and selectivity and to reduce deactivation and poisoning. Starting from new oxide-based materials with minor demand for noble metals, new material concepts will be explored. Target structures defined by fundamental research will then by transferred to standard FC and u-FC catalysis by using advanced thin-film preparation techniques, such as magnetron sputtering and vacuum deposition. Knowledge-transfer between real and model catalysis will be guaranteed with atomic-level control, using a broad spectrum of surface spectroscopies, in-situ/operando spectroscopies, and microscopies with atomic resolution. Using modern microtechnologies, the novel tailor-made catalyst materials will be integrated into working FC test devices. Prototype devices will be fabricated for performance tests with results fed back to fundamental research. Finally, a process for laboratory-scale production of u-FC batches will be developed. Thus, we will connect surface science, model catalysis, state-of-the-art theory, thin-film-technology, applied heterogeneous catalysis, and microtechnology in an interdisciplinary approach, aiming at the development of a new generation of metal-oxide FC catalysts with improved performance and stability. This project not only will allow to drastically reduce or replace usage of critical materials in the related applications but also will open the pathway to groundbreaking energy storage technologies for mobile devices.",Design of Thin-Film Nanocatalysts for On-Chip Fuel Cell Technology,FP7,30 November 2016,01 December 2012,3675906.0 CHIRALMICROBOTS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"From scientific publications to the popular media, there have been numerous speculations about wirelessly controlled microrobots (microbots) navigating the human body. Microbots have the potential to revolutionize analytics, targeted drug delivery, and microsurgery, but until now there has not been any untethered microscopic system that could be properly moved let alone controlled in fluidic environments. Using glancing angle (physical vapor deposition) we will grow billions of micron-sized colloidal screw-propellers on a wafer. These chiral mesoscopic screws can be magnetized and moved through solution under computer control. The screw-propellers resemble artificial flagella and are the only 'microbots' to date that can be fully controlled in solution at micron length scales. The proposed work will advance the fabrication so that active microbots can be applied in rheological measurements and analytics. We will use these novel probes in bio-microrheology with the potential to probe the viscoelastic properties of membranes and tissues, and to explore questions of micro-hydrodynamics. At the same time we will develop these structures as 'colloidal molecules' and grow asymmetric mesoscopic particles with tailored shapes and properties. We propose experiments that allow the observation of fundamental effects, such as chiral Brownian motion, something that exist at the molecular scale, but has never been observed to date. Similarly, we will be able to demonstrate for the first time chiral separations based purely on physical fields. The proposed technical advances of the growth of nanostructured surfaces will at the same time permit wafer-scale 3-D nano-structuring for photonic and plasmonic applications, which we plan to demonstrate. We will develop a system for targeted drug delivery, study the interaction of swarms of microbots and devise techniques to control and image these swarms.",Chiral Nanostructured Surfaces and Colloidal Microbots,FP7,31 January 2017,01 February 2012,1479760.0 CHIRALMOF,Free University of Brussels * Vrije Universiteit Brussel,health,"The current proposal ChiralMOF has the aim to develop rationally designed novel nanoporous materials for the separation of enantiomers. The separation of enantiomers is of great importance to industry in the domain of medicine. New treatments often rely on medication consisting of pure enantiomers. Enantiomers separation is extremely challenging as the molecules are nearly identical (shape and properties) and is achieved at great cost by relying on expensive, time consuming and complex processes. Separation through adsorption using chiral stationary phases is a viable alternative to the current technology. It is the aim of the project to develop novel porous materials that allow for fast, efficient and inexpensive separation of enantiomers. In the past decade, a new class of porous materials was developed: metal-organic frameworks. This new class of materials can be rationally designed, exhibits highly specific properties and may be economically viable and a stable alternative to classical stationary phases. Surprisingly, very little attention has been devoted to the design of homochiral metal-organic frameworks for enantiomer separation. The chiral structure of these metal-organic frameworks favours the interaction with one specific enantiomer. The preferential interaction, adsorption, is the basis for an efficient chromatographic purification process. A combination of theoretical and experimental work is proposed. Advanced molecular simulations allow for the rational design of novel structures and prediction of the adsorption, separation potential of these nanoporous materials. Computational screening of hypothetical structures is a fast and efficient tool to identify high potential structures. A selected set of promising structures will be synthesized, characterized and validated using state of the art equipment. The validated structures shall be put to a test to assess their potential as stationary phases and stability in industrially realistic conditions.",Rational design of novel nanoprous materials for the separattion of enantiomers,FP7,31 March 2018,01 April 2015,267078.0 CHIRALTEM,Vienna University of Technology * Technische Universität Wien,information and communications technology,"Powerful methods for characterizing and testing magnetic materials are based on X- ray magnetic linear or circular dichroism (XMLD and XMCD) observed in X-ray absorption near edge structures (XANES). The similarities between XANES and energy loss near edge structures (ELNES) in the Transmission Electron Microscope (TEM) have long been recognised, and attempts to 'export' XMLD to the electron microscope were successful. Whereas linear magnetic dichroism has been measured in the TEM it is believed that XMCD cannot be done with electrons. A recent discovery convinced us that this is not true. By a sophisticated experimental setup circular dichroism should be observable in a TEM equipped with an energy spectrometer or energy filter. The expected results of the project are a) the experimental verification of a predicted phenomenon in electron scattering; and b) a new method for the characterization of materials, thus pushing European technology in the growing field of spintronics. It will complement the XMCD applications at synchrotrons and provide new insights for physics and materials science.",Chiral Dichroism in the Transmission Electron Microscope,FP6,18 July 2007,19 July 2004,890000.0 CHOIS,Imperial College London,energy,"The displacement of CO2 emissions by renewable sources of energy critically depends upon the development of low-cost and widely accessible routes to clean energy generation. Of all the renewable energy sources, solar energy has the greatest potential as a world power source. However, the inorganic solar cells available on the market now are too expensive to compete with conventional power sources. Hybrid solar cells are an emerging solar cell technology with a great potential for cheap fabrication. They usually consist of a nanostructured junction of inorganic and organic semiconductors and therefore combine cheap and abundant organic materials with the advantages of inorganic materials in terms of stability and charge transport. Power conversion efficiencies exceeding 3 % have been obtained and there is a large potential for further efficiency improvements. In order to achieve these, a detailed understanding of the working mechanism of hybrid solar cells is of crucial importance. In this project, we therefore aim to carry out an in-depth characterization of hybrid solar cells using a variety of advanced spectroscopic and microscopic techniques and a multidisciplinary approach. The project will consist of three phases: In the first phase, a state-of-the-art hybrid CdS/polymer system will be characterised in order to gain a better understanding of the working mechanism of the solar cells. Following this, hybrid solar cells consisting of different materials and prepared by different methods will be compared and loss processes in the solar cells will be identified. In the final phase of the project, the gained knowledge will be used to propose new materials combinations, which will lead to the construction of more efficient hybrid solar cells. The proposed project will therefore aim to develop a scientific framework that will enable the custom design of hybrid inorganic -organic heterojunctions for high performance solar cells.",Characterisation of hybrid inorganic-organic solar cells by advanced spectroscopic methods,FP7,05 June 2014,06 June 2012,200371.0 CHROMSENSUC,University of Cantabria * Universidad de Cantabria,energy,"This proposal seeks to demonstrate and understand a new class of materials for up-converting infrared (IR) radiation into the visible range through linear radiation-matter interactions, exploiting the optical and electronic properties of trivalent rare-earth ions and organic-based light harvesting compounds. It is known that materials doped with lanthanide ions are capable of combining low energy excitations into higher states via excited state absorptions and energy transfer, resulting in visible or UV emission upon IR excitation. However, the primary absorptions are partially forbidden, which results in a low performance or the requirement of relatively high exciting power. Our aim is to exploit the fact that organic chromophores can have very high absorption coefficients, several orders of magnitude greater than the lanthanide ions, and can act as primary sensitizers by transferring the excitation to them, thus providing an effective increase in absorption and hence, in up-conversion. Following recent discoveries on the nature of the organics to be employed towards this end, we will pursue a twofold strategy. On one hand we will study up-converting organolanthanide polymers incorporating IR chromophores and on the other hand, hybrids based on well known, efficient lanthanide-doped inorganics in combination with IR absorbing organic dyes. The inclusion of chromophore-containing dyes will be done though chemical methods during the synthesis or via coating of nanostructures to exploit inter-molecular and inter-domain energy transfer. We will aim at design rules through opto-structural correlations derived by spectroscopic and characterization experiments at ambient and high pressure of the un-sensitized and sensitized materials. The study and approach are expected to impact on the multidisciplinary Material Science community due to the applications in optical and solar cell technologies as well as Biology due to potential uses in labeling and therapy.",Chromophore-Sensitized Up-Conversion in Lanthanide Materials,FP7,31 August 2016,01 September 2012,100000.0 CIDNA,Technical University of Munich * Technische Universität München,health,"The goal of this proposal is to establish the basic conditions for DNA-based nano-biotechnology. The programme which rests on biochemistry, advanced co-ordination chemistry, molecular spectroscopy, surface physics and theoretical chemistry comprises: (1)the optimisation of topology and dynamics of surface-immobilised DNA hybrids using a novel spectroscopic approach applying electrochemical and spectroscopic techniques in parallel; (2)the development of novel binding procedures of DNA to metal or semiconductor surfaces; (3)tailored modifications of DNA oligomers and assembly of complex DNA architectures as elements of biosensor devices; (4)high-resolution mapping of the metal/DNA interface; (5)the investigation of intra-hybrid charge transfer based on time-resolved optical spectroscopy; (6)the study of interfacial charge transfer using scanning tunnelling microscopy; (7)an assessment of the mechanism of electron transport in DNA hybrids and across metal/DNA interfaces based on NMR structure and sophisticated molecular modelling simulations The strong impact expected of this joint effort rests on the combination of different synthetic approaches, on the high level of structural resolution, time-resolved electron transport dynamics, topology and electrochemistry of surface-immobilized hybrids of DNA and its analogues and single molecules imaging techniques as well as on quantum chemistry and molecular dynamics simulations. Taken together, this so far unique combination of methods in experiment and theory will yield results crucial for existing and future medical diagnostics and DNA-based environmental biosensorics. In terms of immediate exploitation this CIDNA project will rest on novel robust DNA structures and analogues. In more general terms of DNA-chip technology the programme will also assess the potential of (cheap and fast) electrochemical readout periphery.",Control of assembly and charge transport properties of immobilized DNA,FP6,30 June 2007,01 January 2004,2425800.0 CIDWM-NANOSTRIPS,IMEP-LAHC Laboratory,manufacturing,"The recent progress in the fabrication and direct synthesis of laterally confined structures, thanks to lithography techniques, has given rise to renewed interest in understanding the interaction between spin-polarized current and magnetic domain walls (DWs), because of it is a key technology for the future spintronics. Although there are several possible ways in which current can interact with magnetic domains, the most interesting interaction is that in which spin angular momentum transferred from the spin-polarized current results in motion of the domain wall. The main aim of the present project is the study of CIDWM in nanostrips with different configurations of magnetic anisotropy. As a starting point, permalloy nanostrips with longitudinal anisotropy will be analyzed, where the composition will be varied in order to modify the STT. In a second stage, the project will be focused towards more original systems with perpendicular anisotropy. The research combines different activities: elaboration and nanofabrication of metallic nanostrips, study of the domain wall motion induced by spin-polarized current (this includes analysis of DW topology, depinning, velocity, mobility and position as a function of dimensions of nanostrips and current) using advanced magnetic imaging techniques, and advances in the micromagnetic modeling of the spin transfer torque. An important aspect of this project will be the effort for understanding inconsistencies and unresolved issues in the interaction of spin-polarized current with DW (existence and nature of non adiabatic contribution, thermal effects, maximum speed of DW driven by current and magnitude of current required to sustain the motion of DW along a nanostrip), whose answer will determine how useful CIDWM will be for technological applications. Therefore, the project pretends to include a good balance between fundamental, applied and theoretical research",Current-induced domain wall motion in magnetic nanostrips,FP7,08 July 2014,09 January 2010,166145.6 CIF,Imperial College London,information and communications technology,"A wide variety of natural phenomena and technological applications involve flow, transport and chemical reactions taking place on or near fluid-solid or fluid-fluid interfaces. From gravity currents under water and lava flows to heat and mass transport processes in engineering applications and to the rapidly developing field of microfluidics. Both equilibrium properties of a fluid and transportcoefficients are modified in the vicinity of interfaces. The effect of these changes is crucial in the behavior of ultra-thin fluidfilms and fluid motion in microchannels of micro-electromechanical systems, but is essential as well in macroscopic phenomena involving interfacial singularities, such as thin-film rupture and motion of three-phase contact lines associated e.g. with droplet spreading. Interface boundaries are mesoscopic structures. While material properties vary smoothly at macroscopic distances from an interface, gradients in the normal direction of conserved parameters, such as density, are steep with strong variations as the molecular scale in the neighborhood of the interface is approached. This brings about a contradiction between the need in macroscopic description and a necessity to take into consideration microscopic factors that come to influence the fluid motion and transport on incommensurately larger scales. The aim of the proposed research is to develop a class of novel continuous models bridging the gap between molecular dynamics and conventional hydrodynamics and applicable at mesoscopic distances from gas-liquid and fluid-solid interfaces. A combination of analytical techniques, numerical modeling and computer-aided multiscale analysis will be employed. The results of the proposed work will greatly contribute to the fundamental understanding of mesoscopic non-equilibrium phenomena in the vicinity of interfaces and to the development of novel computational methods combining the advantages of molecular and continuous models.",Complex Interfacial Flows: From the Nano- to the Macro-Scale,FP7,03 July 2018,04 January 2010,1273788.0 CILIA,Juelich Research Centre * Forschungszentrum Jülich,information and communications technology,"Sensory systems based on arrays of hairs occur widely in nature and function in diverse sensing scenarios, for instance in air (cerci, external sensing hairs in arthropods), in water (lateral line, neu-romasts in fish) and in a fluid-filled compartment coupled to air through impedance matching de-vices and beamforming baffles (mammalian auditory apparatus). These mechanosensor-systems are amongst the most sensitive sensors known. This suggests that hair-based sensing organs, supported by appropriate neuronal representation and processing, are a model system particularly well-suited for studying the extraction of significant information from noisy environments. The twofold objective of the CILIA project is to identify the common principles underlying this wide-spread use in nature of arrays of mechanical sensory cells for the extraction of significant informa-tion and to make those principles available for design of engineered systems. Because organisms and their environments form tightly coupled interacting systems in which all components environ-mental characteristics and dynamics, sensory and physical morphology, peripheral and central neural processing and behavioural patterns play a significant role this analysis will be carried out at three levels simultaneously: the morphology and mechanics, the neuronal process-ing, and the behavioural strategies of the model-systems. Extraction of significant information is considered an emergent property from processing going on at all three levels. The model systems will be the cerci of crickets, the lateral line system of fish and the auditory system of bats. Knowl-edge gained from a representative sample of species and individuals from a large phylogenetic and ontogenetic range will be used to formulate design rules for man-made or man-mediated sys-tems. These will include organic neuronal networks (based on neural cells), MEMS based artificial electro-mechanical hair-sensors, and artificial pinnae-movement control.",Customized Intelligent Life-Inspired Arrays,FP6,28 February 2010,28 August 2005,5825000.0 CIRCLES OF LIGHT,Gesellschaft für Angewandte Mikro- und Optoelektronik mit beschränkter Haftung (AMO GmbH),photonics,"The present project aims at the development of very advanced all-silicon based nanophotonic devices clearly beyond state of the art in terms of functionality, size, speed, cost and functionality. Common component of the envisaged devices are silicon-on-insulator (SOI) technology based circular Bragg resonators with very high quality factors for a concomitant increase of integration density and device efficiency. In particular, the project will realize an approach for a highly compact silicon Raman laser source, a high-speed silicon electro-optic modulator and a novel approach for resonant signal sensing in SOI waveguides. A further increase of packing densities is aimed by the integration of a multi layer SOI waveguide development. To reach the ambitious goals of the project, the focussed effort will be guided by substantial design and modelling activities, optimizing the electro-optic response functions of each sub-component. For an improvement of device performance compared to the state-of-the-art, precise control of free carrier lifetimes in these devices is envisaged by the implantation of ultrafast recombination centers. Device fabrication strongly relies on low-cost, mass fabrication compatible nanolithography technology based on high-precision UV-Nanoimprint. A possible route to monolithically integrated silicon photonic will be demonstrated to enable new device concepts for communication, automotive, infotainment and biomedical system in the future. Therefore, the project activities are expected to have a profound impact on IST-related technologies.",Compact SOI nanophotonic Raman Laser and Modulator and Detector based on Circular Grating Resonator Devices,FP6,31 December 2009,31 August 2006,1648986.0 CIRQYS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"We propose to develop a new scheme for detecting and manipulating exotic states formed by combinations of conductors with different dimensionalities and/or electronic orders. For that purpose, we will use tools of cavity quantum electrodynamics to study in a very controlled way the interaction of light and this exotic matter. Our experiments will be implemented with nanowires connected to normal, ferromagnetic or superconducting electrodes embedded in high finesse on-chip superconducting photonic cavities. The experimental technique proposed here will inaugurate a novel method for investigating the spectroscopy and the dynamics of tailored nano-systems. During the project, we will focus on three key experiments. We will demonstrate the strong coupling between a single spin and cavity photons, bringing spin quantum bits a step closer to scalability. We will probe coherence in Cooper pair splitters using lasing and sub-radiance. Finally, we will probe the non-local nature of Majorana bound states predicted to appear at the edges of topological superconductors via their interaction with cavity photons.",Circuit QED with hybrid electronic states,FP7,31 January 2018,01 February 2013,1456608.0 CLATHPOL,University of Geneva * Université de Genève,health,"The 'CLATHPOL' project focuses upon a fundamental aspect of Clathrin Coat Vesicle formation. The critical biochemical (clathrin/adaptor interactions, membrane composition) and physical parameters (deformation forces, role of pre-induced curvature) controlling the shape and polymerization rate of clathrin coats will be determined and the forces applied on the membrane by clathrin polymerization will be measured. The 'CLATHPOL' project will investigate the complex interactions driving clathrin coat assembly by developing improved bio-mimetic model systems to capture the complexity of biological membranes. The kinetics of clathrin polymerization and the dynamics of membrane shape generation will be studied by fast videomicroscopy using a membrane sheet assay to track coat formation on membranes exposed to various mixtures of clathrin and adaptor proteins. Membrane deformations will also be visualized using fluorescently labeled proteins. In the second stage, the forces on the membrane caused by clathrin polymerization will be measured using Giant Unilamellar Vesicles (GUVs). The membrane tension of the GUVs will be modulated by micropipette aspiration while membrane rigidity will be varied by changing lipid composition. Finally, the influence of membrane curvature on the dynamics and structure/geometry of the clathrin lattice will be determined using nano-patterned substrates with controllable and well-defined surface curvature. Membrane binding and lattice formation will be followed by Total internal reflection fluorescence (TIRF) microscopy and high speed atomic force microscopy.",Dynamic study of shape and force generation by clathrin polymerization onto lipid membranes in vitro.,FP7,30 June 2012,01 July 2010,176065.0 CLAY BIOMIMETICS,Trinity College Dublin,health,"Biomimetics is a fast growing multidisciplinary field leading to the fabrication of novel materials with remarkable mechanical properties. Natural bone is a complex biomineralized system with an intricate hierarchical structure. It was widely reported that a typical secondary bone contains around 65 wt.% mineral phase, 25 wt.% organic and 10 wt.% water, among which carbonated hydroxyapatite (HAp) and collagen fibrils are the major components for the mineral and organic phases, respectively. High stiffness and large surface area fibrous clays, halloysite and sepiolite, will be used for the first time to biomimic collagen fibrils as the templates for the growth of HAp nanocrystals. Natural biopolymers, such as anionic sodium alginate, and cationic amino acids (lysine and arginine) and chitosan will be used to interact with HAp-clay composites and improve their toughness. HAp nanocrystals will be grown along the fibrous clays via co-precipitation methods, followed by preparing HAp-clay-biopolymer hybrid membranes by layer-by-layer (LBL) assembly. Processing conditions, materials composition and LBL assembly approaches will be varied to investigate their effects on structure and properties of the hybrid membranes. The chemical and crystalline structure of the HAp grown will be characterized, and its growth mechanisms in the presence of clay will be studied. Interfacial interactions among HAp, clay and biopolymer will be investigated, and the morphology of the hybrid membranes will be observed. Physical and mechanical properties, biodegradability, protein adsorbability as well as regeneration function of the membranes obtained will be measured. The resultant HAp-clay-biopolymer hybrid membranes are expected to have a good combination of stiffness and toughness through the bottom-up colloidal assembly of stiff fibrous HAp-clay with ductile biopolymers, and will have great potential in bone repair and regeneration in particular in scaffolds for tissue engineering.",Layer-by-layer assembly of novel bone-mimetic hydroxyapatite-fibrous clay-biopolymer hybrid membranes,FP7,17 October 2011,18 January 2010,251299.0 CLEAN,STMicroelectronics Srl,information and communications technology,"With the advent of nanometric devices, the relevance of leakage power has grown tremendously. All technology roadmaps, as well as the results from advanced semiconductor labs indicate leakage as the real showstopper for the future generations of nanoelectronic circuits if proper counter-measures will not be taken. To be successful, and thus leading to the capability of fabricating chips with sub-65nm technologies, such counter-measures must be rooted in the design domain, as process improvement will not be sufficient to cope with the increased leakage currents in MOSFETs. In other terms, time has come for considering leakage reduction also a design problem, and not only a technology problem. CLEAN will contribute in a decisive way to the solution of the problem of controlling leakage currents in CMOS designs below 65nm, which is of strategic importance in the ASIC and SoC design landscape. The RandD effort will crystallize around the development of new leakage models for nanometric technologies usable at different levels of abstraction, from device to behavioral, innovative circuit and architectural solutions for efficient leakage management, novel methods and prototype EDA tools for automatic leakage minimization. Such methods and tools will be integrated into commercial EDA frameworks, thus providing comprehensive solutions for power-driven design. The CLEAN Consortium features the right mix of competence (semiconductor vendors, EDA vendors, research institutes) and the appropriate mobilization of resources to guarantee the successful achievement of all the project objectives. Tight links to on-going European projects targeting advanced silicon technology development (e.g., the NanoCMOS IP and its possible successor, PullNano) will guarantee synergy and convergence of objectives, towards the establishment of design capabilities that will be key for consolidating and growing the European competitiveness in the nanoelectronics business of the future.",Controlling LEAkage power in NanoCMOS SoCs,FP6,31 October 2008,31 October 2005,4510000.0 CLEAN WATER,National Centre of Scientific Research Demokritos Institute of Microelectronics,environment,"The concept of the project is based on the development of innovative nanostructured UV-Visible photocatalysts for water treatment and detoxification by using doped TiO2 nanomaterials with visible light response. The project aims at an efficient and viable water detoxification technology exploiting solar energy and recent advances in nano-engineered titania photocatalysts and nanofiltration membranes for the destruction of extremely hazardous compounds in water. To this aim, the UV-vis responding titania nanostructured photocatalysts will be stabilized on nanotubular membranes of controlled pore size and retention efficiency as well as on carbon nanotubes exploiting their high surface area and unique electron transport properties to achieve photocatalytically active nanofiltration membranes. This will be the crucial component for the fabrication of innovative continuous flow photocatalytic-disinfection-membrane reactors for the implementation of a sustainable and cost effective water treatment technology based on nanoengineered materials. Comparative evaluation of the UV-visible and solar light efficiency of the modified titania photocatalysts for water detoxification will be performed on specific target pollutants focused mainly on cyanobacterial toxin MC-LR and endocrine disrupting compounds (EDC) in water supplies as well as classical water pollutants such us phenols, pesticides and azo-dyes. Particular efforts will be devoted on the analysis and quantification of degradation products. The final goal is the scale up of the photocatalytic reactor technology and its application in lakes, tanks and continuous flow systems for public water distribution.",Water Detoxification Using Innovative vi-Nanocatalysts,FP7,05 July 2014,06 January 2009,1705224.0 CLEAN-ICE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),transport,"The key objective of this project is to promote cleaner and more efficient combustion technologies through the development of theoretically grounded and more accurate chemical models. This is motivated by the fact that the current models which have been developed for the combustion of constituents of gasoline, kerosene, and diesel fuels do a reasonable job in predicting auto-ignition and flame propagation parameters, and the formation of the main regulated pollutants. However their success rate deteriorates sharply in the prediction of the formation of minor products (alkenes, dienes, aromatics, aldehydes) and soot nano-particles, which have a deleterious impact on both the environment and on human health. At the same time, despite an increasing emphasis in shifting from hydrocarbon fossil fuels to bio-fuels (particularly bioethanol and biodiesel), there is a great lack of chemical models for the combustion of oxygenated reactants. The main scientific focus will then be to enlarge and deepen the understanding of the reaction mechanisms and pathways associated with the combustion of an increased range of fuels (hydrocarbons and oxygenated compounds) and to elucidate the formation of a large number of hazardous minor pollutants. The core of the project is to describe at a fundamental level more accurately the reactive chemistry of minor pollutants within extensively validated detailed mechanisms for not only traditional fuels, but also innovative surrogates, describing the complex chemistry of new environmentally important bio-fuels. At the level of individual reactions rate constants, generalized rate constant classes and molecular data will be enhanced by using techniques based on quantum mechanics and on statistical mechanics. Experimental data for validation will be obtained in well defined laboratory reactors by using analytical methods of increased accuracy.",Detailed chemical kinetic models for cleaner internal combustion engines,FP7,11 June 2015,12 January 2008,1869450.0 CLEAN4YIELD,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,energy,"While nanotechnology was originally limited to small areas of a few cm2, the quest for lower costs has been the latest years the drive for developing processes utilising larger substrate sizes at increasing throughputs. A typical example is the flat panel display industry where the push to larger gen size and faster processing has resulted in a significant cost reduction. The next challenge here is the move to smaller feature sizes. Large area processing at high speeds is optimal when using roll-to-roll (R2R) processing, able to deliver the ultimate cost reduction. Flexible innovative thin film devices, like organic light emitting diodes (OLEDs) for lighting, photo voltaic (PV) and organic photo voltaic (OPV) modules, organic circuitry, printed electronics and thin film batteries, are currently developed using this kind of processing. The overall objective of Clean4Yield is the development and demonstration of technologies and tools for nano-scale detection, cleaning, prevention and repair of defects and contaminations in nano-scale layers. The R2R production processes for OLED, OPV, and high-end moisture barrier layers on flexible substrates will serve as development platform for the various methods. Clean4Yield will demonstrate that the developed methods increase yield, reduce production costs, and improve performance and operational device lifetimes of these applications. The developed technologies will be easy to adapted for other large-scale production technologies of other nano layer applications.",Contamination and defect control for increased yield for large scale R2R production of OPV and OLED,FP7,30 April 2015,01 May 2012,7060000.0 CLEAR-UP,Eberhard Karls University of Tübingen * Eberhard Karls Universität Tübingen,construction,"Clear-up presents a holistic approach to the reducing operational energy use in buildings. By development and novel use of nano-materials it aims to increase energy performance in heating, ventilation, air conditioning (HVAC) and lighting systems, and to improve indoor air quality using catalytic purification. Clear-up’s solutions are designed for retro-fitting existing buildings and of course for new constructions. It will achieve this by addressing four key components which control the indoor environment: • Windows. Clear-up will advance the practical use of shutters and electrochromic window foils which reduce the building cooling load and along with light-guide technology, reduce the need for artificial lighting. • Walls. Clear-up will use photocatalytic materials for air purification and nano-porous vacuum insulation in combination with phase change materials to passively control temperature. • Air Conditioning. Clear-up will advance technologies for demand controlled ventilation and improved air quality. • Sensors and control provide an underpinning technology for Clear-up’s approach. New sensors will be developed, and their use optimised for the operation of smart windows; demand controlled ventilation; and catalytic purification. Clear-up will develop, install, measure and evaluate technological solutions in the laboratory, in a large-scale testing facility and in real world applications. Its approach will be demonstrated at the UN Climate Summit in Copenhagen, 2009. The safety of new materials will be considered; it will propose inputs to standards and environmental product declarations for its technologies. Clear-up will also investigate environmental and economic lifecycles for components and systems. The practical issues of exploitation will be addressed in cooperation with industry bodies ECTP, ECCREDI and ENBRI providing access to large firms and SMEs.",Clean buildings along with resource efficiency enhancement using appropriate materials and technology,FP7,10 July 2014,11 January 2008,8300000.0 CLERMONT4,University of Rome Tor Vergata * Università degli Studi di Roma Tor Vergata,photonics,"The discovery of Bose-Einstein condensation (BEC) of exciton-polaritons in 2006 and the demonstration of room-temperature polariton lasing in 2007 have opened the way to realisation of a new generation of optoelectronic devices referred to as polariton devices. The research on exciton-polaritons and polaritonics allows the quantum effects of superfluidity, entanglement, squeezing of light to be brought to the everyday life and used in new light sources, optical switches, modulators and memory elements. The fundamental principles of polariton physics have been established by our previous networks "CLERMONT" and "CLERMONT2" within the 5th and 6th FP. The breakthrough achieved in 2006-2007 brings the polaritonics on a new level and makes its rapid development in Europe an overall strategic priority. Our present consortium composed by 10 European academic teams and supported by 6 leading industrial groups has a critical mass in polariton physics and technology. We intend to form a new generation of solid state physicists able to maintain the European leadership in this rapidly developing interdisciplinary research field. Four of the present partners took part in the discovery of the BEC of polaritons and polariton lasing, six others have given key contributions into polaritonics over the last decade. The Coordinator of the project holds the Marie Curie Chair of Excellence "Polariton Devices" at the university of Rome. We propose 16 full term PhD and 3 postdoc projects to be realized at two network nodes each with a compulsary training in industry. We shall organize the international conference on Optics of Excitons in Confined Systems in 2009, 3 international conferences on Physics of Light-Matter Coupling in Nanostructures and 2 Summer Schools on Nanophotonics. The project will form a world-leading international team of researchers capable to implement the ideas of polaritonics in a new generation of optoelectronic devices.",Exciton-polaritons in microcavities: physics and devices,FP7,31 August 2013,01 September 2009,4278121.0 CLIP,European Specialist Printing Manufacturers Association,health,"The project will focus on three development aims: 1) development, formulation and feasibility assessment of several lower-cost alternatives for Silver nanoparticle based conductive inks 2) for these lower-cost inks finding alternatives for conventional screen printing, which allow digital printing combined with high resolution printing and enable contactless printing, which improves quality and reliability of circuits 3) demonstration of system concepts for Printed Electronics in two different application domains: a. Printing of smart packaging tags and labels, specifically for pharmaceutical applications b. High speed low cost antennas for contactless cards and RFID tags Main impact on SMEs will be: • Allow SMEs to access extensive new markets and customers with large potential for revenue generation • Allow SMEs to surplus their current products or product offering with remarkable, new, high-valued features that will increase (perceived) product value • Provide SMEs with the information, (partnering) contacts and tools to make the transition • Identify the costs/impacts involved to allow SMEs to make an informed decision.",Enhancing Printed Electronics Applications by SMEs,FP7,31 May 2013,01 June 2010,2691790.0 CLUSTERCAT,University of Birmingham,manufacturing,"In order to design new or refined model nanocatalyst materials for more energy efficient and economical chemical processes, the proposed project incorporates three key areas of nanoscience: (i) Nanoscale materials engineering: the synthesis of stable arrays of supported, size-selected nanoclusters (ii) Advanced characterisation techniques: Scanning Transmission Electron Microscopy, and (iii) Nanoscale process engineering: investigating the reactivity/selectivity and stability of the model nanocatalysts under realistic reaction conditions. The model nanocatalysts will be prepared using the state-of-the-art apparatus based on radio-frequency magnetron plasma sputtering source, which is coupled to a lateral Time-of-Flight mass filter for size-selecting the nanoclusters. The wafer dicing method will be employed, for the first time, to convert the planar nanocatalysts to a high surface area nanocatalyst powders. The three-dimensional atomic structures and the stability of the nanoclusters during reaction conditions will be investigated by a spherical aberration-corrected Scanning Transmission Electron Microscope (pre- and post-reaction analysis). Finally, the performance of the model nanocatalysts will be explored by conducting the liquid phase hydrogenation reactions over nanocluster powder samples. The relevance of the present project within the Marie Curie Framework is reflected in the knowledge transfer between the host expertise at University of Birmingham (i and ii) and the Fellowship candidate experience from the Technical University of Munich (i and iii). This will also bring together technical innovations developed across the European Universities. In addition, the intention of this project is to motivate industrial development toward the design of new nanocatalytic processes that are less toxic and require less material and energy. The success of this project will have significant impact in advancing the field of modern catalysis in the European Research Area.","NanoEngineering of Model Catalysts Based on Supported, Size-selected Nanoclusters",FP7,03 April 2016,07 January 2011,209592.8 CMA,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"It is proposed to contribute to a strengthening of the competitiveness of metallic materials for the benefit of European industries by the formation of a European Network of Excellence CMA developing within four years into a European Integrated Centre for the Development of New Metallic Alloys and Compounds (IDEA). This Centre will unite an appropriate number of specialised laboratories to form an integrated body dedicated to the intelligent search for new metallic materials and their development towards technological applicability. Collaborating on a first challenging topic, Complex Metallic Alloys, these laboratories are going to build up IDEA, put it into practice and demonstrate that it is capable to embark upon the research and development of materials that could not be dealt with before. CMA will unite 20 high-reputation core-group members (representing a person-year critical mass of 252p.y and 84 PhD students in 12 countries). Accessible due to very recent progress in materials science, Complex Metallic Alloys offer great potential for innovation. Examples of this potential are heat insulation at low temperature (using e.g. AI-Cu-Fe compounds (sic)), hydrogen storage, thermoelectricity, enhanced catalytic efficiency at lower cost, reduced friction, optimised composites, nanostructuration of metallic agregates or thin films, development of innovative coating processes adapted to complex surface shapes, etc. On this basis, the project is designed to strengthen the competitiveness of European industries wherever materials need to offer hybrid properties, being both structural and functional, or embody an extraordinary combination of properties that are mutually excluding in conventional materials. Innovative management procedures for knowledge handling and networking, grant administration, organisation of conferences, access to platforms and durable integration of women will be taken, together with an ambitious programme of summer schools.",COMPLEX METALLIC ALLOYS,FP6,30 June 2010,01 July 2005,7300000.0 CMNHFRF,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),photonics,"Passive systems such as inductors, capacitors and transformers, integrated on-chip, are essential building blocks of all analogue RFICs and their performance at current and future CMOS processes is a major bottleneck to successful system integration at the single-chip level radios at high frequencies. Further, this bottleneck prevents a larger-scale integration of more complicated analogue stages essential for wireless communication chips, most notably of filters which currently remain off-chip. Part of the problem relates to physical properties of standard CMOS processes, i.e., metal and substrate losses and couplings. Another part is the inadequacy of lumped-element design rules for correctly accounting for fully-electromagnetic physical effects at high frequencies. Finally, absence of multi-disciplinary research linking the above physical and RF design problems to a synthesis cycle of CMOS-compatible material processes with optimized high-frequency material properties, possibly including composite electromagnetic materials and photonic crystals. This proposal will contribute to remedying these defficiencies in a technologically relevant way, by: First, using novel material Si processes, such as porous Si patterned with high-K or alumina dielectrics, to analyze and optimize the full-wave electromagnetic design of on-chip high-Q passives. It will then use these optimized cells to derive a comprehensive design methodology for on-chip passband filters, including accurate broadband circuit models, where the remaining technology process loss will be mapped to the appropriate circuit sub-topologies. Lastly, these losses will be cancelled by the insertion of appropriately optimized FET interconnections of minimum noise figure, to complete a realistic on-chip filter design cycle directly implementable to the semiconductor industry.","CONVERGENCE OF MICROELECTRONICS, NANOTECHNOLOGY AND HIGH FREQUENCY RF ENGINEERING",FP6,31 March 2007,01 April 2005,80000.0 CNMD,Cytec Engineered Materials Limited,transport,"Among the characteristics of primary structures of a Green Regional Aircraft, it appears essential to assure a relevant efficiency with respect to the requirements for lightning strike protection, potential discharge, electrical grounding and electromagnetic shielding. The introduction of advanced composites materials in modern aircraft primary and secondary structures presents special challenges due to their inherent low electrical conductivity. Although carbon fibers are good conductors, polymeric matrixes are excellent dielectric, reducing composite structures conductivity. Cytec Engineered Materials (CEM), relying on the great experience acquired in decades of research, manufacturing and application of advanced epoxy systems to the aerospace market, can bring to this problem the know-how required to reach an advanced and sustainable solution. We believe that epoxy resins modified with carbon nanotubes can have a great potential as matrixes for next generation prepreg and composite materials with tailored electrical properties. The objective of this work is the use of carbon nanotubes for a new nanomodified prepreg development. Work package 1 is focused on the selection of an epoxy/nanofilled system and the identification of manufacturing prepreg processes parameters. Work package 2 is focused on the manufacturing and characterization of coupons and small panels for properties evaluation and final product demonstration. A specific testing campaign will be carried out to evaluate the nanomodified composites electrical properties. The test plan will include both DC and AC conductivity and electromagnetic shielding efficiency measurements. In addition the effects of a lightning strike event on a composite structure will be evaluated.",Development of nanofilled prepreg for aircraft composite structures.,FP7,12 July 2012,01 January 2010,124800.0 CNT-IN-FRPC,Sabanci University * Sabancı Üniversitesi,energy,"Structural composites that are combination high strength fibers with a continuous polymer matrix are already utilized in a variety of applications including aerospace, transportation, construction, marine goods and sporting goods. .As the usage of these materials increases rapidly and new application areas emerge for materials, performance expectations to meet these needs also rise. the energy output in wind turbine blades is directly proportional to the area swept by the rotor (square of the diameter of the blade) and with the aid of composite structures that are mechanically stronger, the length of blades used in wind turbine blades can be increased and the weight can be decreased with new designs, which results in higher energy output. Carbon nanotubes have recently attracted great attention in the field of material science due to their unique mechanical, electrical and thermal properties combined with their nanoscale size, high aspect ratio and low density. The proposed project offers a unique methodology for the production of next generation structural composites using chemically functionalized carbon nanomaterials for improved mechanical performance.",TAILOR-MADE BIFUNCTIONAL CARBON NANOTUBES TO ENHANCE INTERFACIAL INTERACTIONS IN FIBER REINFORCED POLYMERIC COMPOSITES,FP7,28 February 2017,01 March 2013,100000.0 CNTBBB,Imperial College London,health,"Targeted drug delivery across the blood brain barrier (BBB) to the central nervous system is a large challenge for the treatment of neurological disorders. This 4 year ERC program is aimed towards the evaluating the BBB penetration capacity and toxicological potential of novel carbon nanotube (CNT) carriers using an integrated multidisciplinary approach. State-of-art characterisation techniques developed by the PI will be applied and further developed to detect the interaction of carbon nanotubes with in vitro BBB model and neuronal cells. Specific aims: 1. Identify the mechanisms of translocation of CNT across the endothelial cells which comprise the BBB, as well as uptake by neuronal cells in vitro. 2. To investigate the effect of length, diameter and surface charge of CNTs on the BBB and neuronal cells penetration capacity in vitro. 3. To investigate the toxicological profile of CNT on the BBB and the various neuronal cell types (immortalised and primary neuronal cultures). 4. Develop protocols to assess whether the CNTs degrade inside the cell. The ERC Grant will consolidate the new Research Group in nanomaterials-cell interfaces, and allow them to perform stimulating investigator-initiated frontier research in nanotoxicology and nanomedicine. To this end, a multi-disciplinary laboratory will be realized within the framework of this 4-year the ERC Programme. This will permit the group around the PI, to expand activities, push limits, create new boundaries, and develop new protocols for studying nanoparticle-cell interactions in close collaboration with ICL s Department of medicine and chemistry. Within the proposed program there is an underlying ambition both to gain a fundamental understanding for which parameters of CNTs determine their penetration capacity through the BBB and also to assess their toxicological potential at the BBB two highlighted themes by the ERC.",Targeting potential of carbon nanotubes at the blood brain barrier,FP7,31 January 2016,01 February 2011,1229998.0 CNTCONTACT,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),information and communications technology,"Carbon nanotubes (CNTs) are attracting an immense research effort due to their remarkable electronic properties. The ability to integrate CNTs into applications such as sensors and low power transistors will allow the technology to fully benefit from these structures. The advantages CNTs offer include high sensitivity, very low power requirements, and the ability to use nanometer scale components. Key issues remain before the full potential of CNTs can be exploited: Low resistivity contacts must become available, CNTs must interface with high-k dielectrics, and we must understand their transport properties thoroughly. This project will address all three of these challenges. Further challenges related to growth and processing control are addressed by numerous researchers in the field.",Doped semiconductor contacts for low resistance contacts to carbon nanotubes,FP7,09 June 2015,06 January 2011,0.0 CNTF COMPOSITES,Plasan Sasa Ltd.,transport,"Carbon nano tubes (CNT) are nano-scale materials with exceptionally high mechanical, electrical and thermal conductivity properties. For example the Tensile strength of a single walled nano tube is ~ 1TPa. The thermal conductivity at room temperature for single Multiwalled CNT was measured to be greater than 3000 W/m•K and perfect CNT are also able to conduct electrons without heat loss. Most of the known properties related to CNT's come from the investigation of a single CNT while the main goal remains to exploit those properties in the macro scale through the use of highly oriented and aliened CNT's. It is possible to exploit the exceptional properties of CNT by producing fibres which are based on CNT's as building blocks. These kinds of fibres may be called CNT fibres or CNTF. One approach to produce CNTF is the process of spinning from a CVD process. This process was selected as a potentially applicable process for industrial scale production of CNTF. It has been proved that scale up of the process is feasible while maintaining an affordable and stable process suitable for large scale manufacturing. In order to cross the gap between feasibility in the lab scale and industrial pilot a research effort needs to be carried out in this field. The CNTF by itself is a material suitable for various engineering applications. This is achieved due to the fact that in the CNTF all the remarkable characteristics of CNT's are expressed. Another route to exploit the material properties of the CNTF's is to incorporate them in a polymeric matrix to result in a CNTF based composite material. Since we are dealing with a new and innovative fibre type further research is needed in order to find and optimize the polymeric matrix type for the various applications suggested. These applications are: structural and conductive composites, composites for the automotive industry, composites for the aviation industry and even as an armour material.",CNTF (Carbon Nano Tube Fibres) COMPOSITES,FP7,08 July 2016,09 January 2010,666148.0 CNTQC,Leibniz Institute for Solid State and Materials Research Dresden * Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden eV,information and communications technology,"Topological quantum computation, based on the encoding of quantum information in non-local degrees of freedom, provides a promising route for a working quantum computer not affected by quantum decoherence. A possible way of realizing this non-locality is to encode qubits into so-called Majorana fermions - quantum particles that are their own antiparticles. As an elementary particle, Majorana fermion is a hyphotetical object. However in condensed matter it can be built out of what nature offers us: electron and hole excitations. Recently a number of experimental setups have been proposed to support Majorana zero modes, among which are planar superconductor-semiconductor heterostructures and superconductor-topological insulator hybrids. Despite the fact that such solid-state-devices consist of rather 'conventional' building blocks, the actual experimental observation of Majorana fermions is still the biggest challenge in the field. The experimental difficulty stems from a required, very delicate fine-tuning of intrinsic materials parameters, e.g. strength of the Rashba spin-orbit coupling, and external physical quantities, e.g. strength of externally applied magnetic fields. The aim of CNTQC is to overcome these hurdles by designing, fabricating and testing novel platforms where strong curvature-induced quantum effects can generate the requirements of the Majorana fermion's cocktail in a controlled manner. The pursued approach will exploit modern nanostructuring technology to transform very thin nanomembranes into three-dimensional nanoarchitectures with a strongly curved geometry. The combined experimental and theoretical understanding of the geometrically-induced topological superconducting state aims to pave the way towards a direct demonstration of the existence of Majorana fermions in these curved solid-state devices. This concept sets a stage for the generation of versatile platforms for topological quantum computation.",Curved nanomembranes for Topological Quantum Computation,FP7,05 July 2019,06 January 2014,1582081.0 CO OXIDATION,Foundation for Research & Technology Hellas (FORTH),transport,"A multiscale theoretical investigation of the CO oxidation on Au nanostructures supported on various oxides is proposed. Since Haruta’s 1987 discovery of the exceptional activity of gold (Au) nanoparticles (2-5 nm in diameter), many groups have verified this exceptional activity towards many reactions when supported on certain oxides. For example, the Au/TiO2 system exhibits unprecedented activity in low temperature CO oxidation via O2. CO oxidation is of paramount importance not only in automotive catalysis but also in modern energy related applications including hydrogen production via the water-gas shift reaction with steam from fossil and renewable fuels, hydrogen purification via selective oxidation of hydrogen with oxygen, fuel cells, etc. Although the high activity of Au is beyond any doubt, there is still much debate on the nature of active sites and the underlying reaction mechanisms. Herein, a multiscale bottom-up approach will be developed that cuts among “ab-initio” and semi-empirical (free-energy related) techniques and integrates this information into first-principles Monte Carlo kinetics simulations in order to explain the exceptional reactivity of Au nanoparticles on certain supports, explore its electronic properties and eventually pave the way for design of efficient catalysts for hydrogen purification and fuel cells applications.",A multiscale theoretical investigation of carbon monoxide oxidation on gold nanomaterials for energy and environmental applications,FP7,03 July 2013,04 January 2008,210567.21 CO2PHOTORED,Polytechnic University of Valencia * Universitat Politècnica de València,health,"The reduction of carbon dioxide has received a great deal of attention in recent years. With increasing concerns about rising atmospheric CO2 levels, scientists have discussed new strategies to reduce the impact of CO2 on global warming. Many ideas have involved trapping the 'greenhouse gas' and converting it into fuels and organic materials, using either light or electrical energy. In this context, one of the main challenges of photocatalysis is to enhance the photoreduction of carbon dioxide. This is an ambitious aim, but it could be achieved now because of the convergence of new experimental and theoretical developments. More specifically, the aim of the project is the activation of carbon dioxide followed by its photoreduction toward useful organic compounds using electron-transfer processes on heterogeneous catalysts. In this context, the new topics that will be studied are: 1) the semiconductor deposition/encapsulation on/in a nanoporous support/host which will acts as a cooperative entity in the photoreduction of CO2 by performing a proper adsorption of the substrate molecules; 2) study and development of the new doping strategies for improving the photoactivity and the ability to absorb visible solar spectrum; 3) the development of a new CO2 mitigation strategy by studying and preparing photoreducers and hybrid photosensitizer -semiconductor systems, and 4) use of the developed materials in a photoreactor. The last topic represents the first step into a new technology for artificial photosynthesis. Reaching the objectives of the proposal will open a wide field of investigation that goes far beyond questions of developmental of photocatalysis. The originality and innovative nature of the project lie in the link between chemical, physical and photo-physical properties of the developed materials.",Carbon dioxide photoreduction: A great challenge for photocatalysis,FP7,25 October 2014,26 October 2012,176053.0 COCHALPEC,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"Solar energy is renewable and abundant enough to meet the growing energy demand, but its variability limits the application. Direct storage in the form of a clean fuel, like hydrogen, would solve this problem. Photoelectrochemical (PEC) cells employ solar energy to split water molecules producing H2 and O2. Thin films of Cu2ZnSnS4 (CZTS) and ZnCuInS2 (ZCIS) have shown remarkable efficiencies in photovoltaics (PV) and preliminary promising results in PEC cells, but costly fabrication. Currently, much attention is being paid to the synthesis of nanocrystals (NCs) of these materials because of their low cost preparation and tunable optical and electrical properties just by controlling the nanometer dimensions of NCs and the composition of the particles, giving more versatility to meet the energetic requirements for water splitting. These new materials in the forefront of PV remain unexplored in water splitting PEC cells to date. In this project, we propose the fabrication of photoelectrodes based on CZTS and ZCIS NCs to perform the water splitting. First, the control over the size, shape and composition of these NCs will be demonstrated using inexpensive solution-based techniques. Next, two photoelectrode configurations (viz. sensitized metal oxide and 3D-arrays of NCs) will be pursued applying state of the art overlayers to improve the charge separation and the catalytic activity at the interface with water. Finally a PEC device will be assembled that demonstrates a 5% overall solar to hydrogen conversion efficiency. In this research we propose a bottom-up approach whereby the comprehensive analysis of the interfacial charge transfer will both contribute to the basic science of solar energy conversion systems and optimize the performance of very promising materials for direct solar to fuel energy conversion. Our approach will finally create a significant impact on the scientific and general European communities through the dissemination of the field and the results.",Development of electrodes based on copper chalcogenide nanocrystals for photoelectrochemical energy conversion,FP7,31 May 2015,01 June 2013,184709.0 COCHISE,University of Bologna * Alma Mater Studiorum Università di Bologna,health,"COCHISE is the first step of an activity aimed at the development of enabling micro-technologies to monitor physiological cellular interactions at the single cell level with a high throughput. It will be applied first to the immunological monitoring of anti-tumor vaccinations, singling out the rare effector cells (in the order of 10-3) that are actually active against tumor cells. The sensor that we are developing consists of an orderly matrix of about 4,000 living cells deposited in microwells created in a biocompatible substrate that also serves as a high-density circuit board. The microwells are monitored by an external microscope and have an embedded addressable impedance sensor. The key point is that each microwell can force contact between individual cells, and detect consequences of these contacts. The project integrates on the same platform several technologies such as electronic sensing, microfluidic interfaces for cell dispensing, control of osmotic balance of nutrients, management of evaporation, surface nano-modifications for management of fluid flows (e.g. hydrophilic and/or hydrophobic surface tend to drive or repel droplets) and avoidance or induction of surface cell adhesion. At the system level, cell delivery will leverage recent results that allow to delivery single cells in an effective way. An important side of the research is the definition of new therapeutic and diagnostic protocols for the immunotherapy of cancer. As a first step, we will apply our technology to the analysis of anti-tumor lytic effector cells, for a precise quantification of how many lytic events happen in the array, their locations and timings. A major advantage is that the cells are kept alive and can be retrieved individually for further analysis, such as gene expression profiling.",Cell-On-CHIp bioSEnsor for detection of cell-to-cell interactions,FP6,31 May 2009,31 May 2006,1735400.0 COCOON,Ghent University * Universiteit Gent,energy,"CONTEXT - Nanoporous structures are used for application in catalysis, molecular separation, fuel cells, dye sensitized solar cells etc. Given the near molecular size of the porous network, it is extremely challenging to modify the interior surface of the pores after the nanoporous material has been synthesized. THIS PROPOSAL - Atomic Layer Deposition (ALD) is envisioned as a novel technique for creating catalytically active sites and for controlling the pore size distribution in nanoporous materials. ALD is a self-limited growth method that is characterized by alternating exposure of the growing film to precursor vapours, resulting in the sequential deposition of (sub)monolayers. It provides atomic level control of thickness and composition, and is currently used in micro-electronics to grow films into structures with aspect ratios of up to 100 / 1. We aim to make the fundamental breakthroughs necessary to enable atomic layer deposition to engineer the composition, size and shape of the interior surface of nanoporous materials with aspect ratios in excess of 10,000 / 1. POTENTIAL IMPACT Achieving these objectives will enable atomic level engineering of the interior surface of any porous material. We plan to focus on three specific applications where our results will have both medium and long term impacts: - Engineering the composition of pore walls using ALD, e.g. to create catalytic sites (e.g. Al for acid sites, Ti for redox sites, or Pt, Pd or Ni) - chemical functionalization of the pore walls with atomic level control can result in breakthrough applications in the fields of catalysis and sensors. - Atomic level control of the size of nanopores through ALD controlling the pore size distribution of molecular sieves can potentially lead to breakthrough applications in molecular separation and filtration. - Nanocasting replication of a mesoporous template by means of ALD can result in the mass-scale production of nanotubes.",Conformal coating of nanoporous materials,FP7,31 December 2014,01 January 2010,1432799.0 COCOPOPS,University of Zaragoza * Universidad de Zaragoza,health,"The cooperative chemistry of polyoxometalates (POMs) and metal nanoparticles (NPs) still remains a relatively unexplored area of the chemical sciences despite showing remarkable potential in fields as diverse as catalysis and medicine. The ability to exert synthetic control during the self-assembly of any nanostructured material constructed from molecular precursors is of fundamental importance for its application as new material or device. In recent years, zero-valent state plasmonic noble-metal NPs have received a remarkable amount of attention due to their distinctive chemical, physical and optical properties. Efficient synthetic protocols are therefore required in order to reliably access a range of NP shapes, sizes and elemental compositions in high yield with minimal cost and toxicity. One emerging approach involves the use of POMs as reducing, capping, and stabilising agents. Dr. Scott G. Mitchell (the applicant) will develop new research skills by partnering him with Dr. Jesús MartÃnez de la Fuente and an internationally recognised group of nanotechnologists: The Nanotherapy and Nanodiagnostics group (GN2) at the Institute of Nanoscience of Aragón (INA) at the University of Zaragoza. The proposed research combines POMs and metal NPs as nanohybrid materials possessing responsive and switchable properties that are tuneable on the nanoscale. This two-year project will train the applicant in essential areas of microscopy as he generates novel materials which will be not merely of academic interest, but could have a number of real world applications in medicinal devices, materials science and catalysis. This next step in Dr Mitchell's career is crucial in determining his long-term development; therefore the proposed work builds on existing skills developed during his PhD and postdoctoral research and develops completely new areas of research in inorganic chemistry and nanotechnology, acting as an ideal springboard for the applicant's subsequent career.",The Complimentary Combination of Polyoxometalates and Metal Nanoparticles,FP7,30 April 2015,01 May 2013,173370.0 CODES,IDS Ingegneria Dei Sistemi SpA,information and communications technology,"Electromagnetic software plays a key role in the design and manufacturing of innovative electronic sub-systems: wireless components, micro sensors, smart antennas, high-frequency active and passive devices, MEMS, etc. These new emerging devices have a major impact on a large number of strategic applications, such as mobile communication, broadband networks, security systems, earth remote sensing, transport monitoring, de-mining, tele-medicine etc. by determining their technical feasibility.During the last years, the SMEs involved in this proposal developed and maintained state-of-the-art electromagnetic software offering services to Industries worldwide and achieved a solid international market success thanks to the result accuracy and the reliability of their software tools.New products coming from USA and Far-East are now reducing the competitive edge and the proposer SMEs believe that, in the next future, the marketing success of their products will be strongly dependent from the computational speed of their software. Higher and higher performances will be, in fact, required to face increasing sub-system complexity and reduce design time. In the past, parallel mainframes were used to improve performance, but the high costs due to new hardware and software modifications limited its usage to very narrow applications. Today, GRID computational technology offers a robust and seamless environment to achieve high speed performance and, in this frame, the involved RTD Providers are committed to develop a GRID solution, able to exploit at best the latest Information Technology developments applied to the electromagnetic design.The outcome of this research project will enable the proposer SMEs to commercialise a software add-on product able to boost the performance of their existing electromagnetic design tools. An internal exploitation of the product is also planned, in order to reduce the time-to-solution for the services provided by the SMEs.",Computing On Demand for Electromagnetic Software and applications,FP6,31 October 2007,01 May 2005,879107.5 CODICE,Fundación Tecnalia Research & Innovation,construction,"Albeit the C-S-H gel constitutes the main ingredient of cementitious skeletons and their life-service depends crucially on it, the possibility of tuning the intrinsic nature and properties of the C-S-H gel has been simply out of reach. Fortunately this long-standing impossibility can be currently overcome by the complementary action of new experimental capacities and stronger simulations schemes which explicitly pay attention to the nanoscale. Recent nanoindentation experiments have revealed that the C-S-H gel can present itself either in a low stiffness and low density variety (called LD C-S-H gel) or in a variety with a high stiffness and high density (called HD C-S-H gel). This dissimilar bearing capacity is indeed much more pronounced in their resistance to osteoporosis-like degradation processes (aging!). The question that arises is straightforward: Could the formation of the stronger and more durable HD C-S-H varieties be promoted against the LD- ones? CODICE aims to answer to this question by means of on-top-of-the-art simulations. In fact CODICE project aims to develop a serial parameter-passing multi-scale modelling scheme to predict the structural evolution and the mechanical performance of non-degraded and degraded cementitious matrices as a function of macroscopical processing variables to guide the design of cementitious materials in which the HD-C-S-H forms are promoted against the LD- C-S-H ones. Improvements of the mechanical properties about the 50 % and 600 % are envisaged for non-degraded and degraded cementitious scaffolds respectively, when compared to conventional designs. Thus, CODICE largely impacts on the competitiveness of the Construction sector, since the simulations 1) will offer an unbeatable and cheap solution to the cement sector to assess and improve the efficiency of cheaper cement formulations and 2) will computationally drive the design of cementitious materials with drastically lower maintenance costs.",COmputationally Driven design of Innovative CEment-based materials,FP7,08 July 2013,09 January 2008,2700000.0 COEF-MAGNANO,University of the Basque Country * Universidad del País Vasco / Euskal Herriko Unibertsitatea,information and communications technology,"The scientific objective of this programme is to achieve a comprehensive knowledge of magnetically coupled systems of reduced dimensionality. Spin configuration, magnetic and electrical properties of patterned nanostructures will be investigated in three kinds of magnetically coupled materials: antiferromagnetic / ferromagnetic (AF/FM), very thin multilayers with perpendicular anisotropy and superconducting / ferromagnetic (SC/FM) bilayers. Thin films will be patterned constraining lateral dimensions in the range of 50 nm to 200 microns. These dimensions are comparable to typical magnetic length scales as domain wall width and spin diffusion length, thus novel phenomena and spin configurations are expected as the size of these elements becomes smaller. Coupling interactions in patterned magnetic systems have attracted much attention due to both still open challenging issues in nanomagnetism and the technological implications in spintronics devices, storage media, biological sensor, and logic units. Four Work packages reveal the challenges and objectives of this proposal. The effect of magnetic coupling in: i) the formation of a vortex state in dots with an in-depth magnetic profile (FeF2/FeNi), ii) competing anisotropy nanostructures (IrMn/FeCo), iii) the domain configuration in YBaCuO/FM hybrid heterostructures, and iv) the stability of Co/CoFeB nanoelements with perpendicular anisotropy, will be systematically investigated. The proposed exchange scheme will train young and experienced researchers from eleven high-class research centers in state-of-the-art nanofabrication and characterization techniques. The success of this project is only possible combining capacities and facilities from all partners.",Coupling effects in magnetic patterned nanostructures,FP7,12 July 2018,01 January 2013,323400.0 COELUX,University of Insubria * Università degli Studi dell'Insubria,transport,"The quality of artificial illumination is a major concern in modern society, where living conditions often deprive us of the comfort of natural light. The global replacement of incandescent with fluorescent or white-LED lighting, foreseen owing to energy-saving constrain, will represent impoverishment in terms of colour-rendering capacity, thus raising the problem to the level of health care. In a scenario where all scientific and industrial efforts are spent on developing low-consumption light sources with the same spectrum as that of the sun, “CoeLux” enters with a ground breaking proposal, based on the evidence that the sun cannot provide natural light in the absence of sky. With the aim of producing those colour distributions captured by artists in their masterpieces, “CoeLux” develops nanocomposite materials, incorporates them in lighting installations, and so recreates the same atmospheric light scattering that produces all colour variety in transmitted sunlight, and the blue tinge in the shade under diffused sky light. In so doing, spectacular sky-and-sun illumination in noon or sunset modes, under a clean or stormy-day sky, will be made available for apartments, working areas, malls, sport centres, railway stations, as well as for squares, parks, and stadiums, during night time. The technology is compatible with low-consumption fluorescent lamps or LED’s, being less demanding in terms of source quality. Finally, “CoeLux” will disseminate the results beyond the project by promoting a European exhibition in which such technological apparatus is shown to provide a unique perspective for a deeper understanding of the connection existing between fine art, architecture, literature, photography and our everyday experience of light.",CoeLux: the sky light reconstruction in artificial illumination by means of solid transparent nanocomposites.,FP7,11 June 2014,12 January 2010,1223176.0 COHEAT,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"We are nowadays capable of controlling and manipulating quantum systems as never before. Quantum technology is close to bringing IT devices to mass scale production. The improvement in the accuracy of fabrication and control of quantum systems starts to pay some results also in different fields of research and application, such as biology.",Coherent heat and energy transport in quantum systems,FP7,02 April 2020,03 January 2014,0.0 COLA'03,Foundation for Research & Technology Hellas (FORTH),manufacturing,"The objective of this project is to support the participation of outstanding young European researchers in the 7th
International Conference on Laser Ablation (COLA'03) and provide high-level training in a scientific area of
high current interest fostering the interaction between young scientists and internationally known experts in the
field.
COLA'03, to be held in Hersonissos, Crete, Greece (October 2003) is a major conference in the field of laser-
matter interactions, that focuses on fundamental studies and technological applications of laser ablation,
attracting scientidsts form both academia and industry. Laser ablation is a highly interdisciplinary field drawing
science and engineering. It plays a key role in current frontier topics, which are among the priority research
themes for the new European Research Area, such as nanoscience and technology, materials processing and
biomedical applications.
Researches in Europe have a leading role in the field of laser ablation promoting European scientific excellence.
The organisation of COLA'03 in Europe offers a great opportunty for advancing the European state-of-the-art
in the field by providing:
- a stimulating environment for fruitful interaction between scientists
- efficient exchange of views between research and industry communities
- a high-quality training to young researchers, essential for their studies and future career.
A high level and dynamic training component in COLA'03 is implemented through:
- the selection of conference topics representing areas of intense current scientific and technological interest
- the invitation of world-known experts to lecture on "hot" topics
- a programme structure with brainstorming lecture-discussion sessions, to allow selected project presentations by
young scientists with leading experts in the field
- the organization of poster sessions, followed by discussion sessions, to allow selected project presentations by<",7th International Conference and Laser Ablation,FP6,30 September 2004,01 October 2003,34620.0 COLDBEAMS,University of Pisa * Università di Pisa,health,"The objective of COLDBEAMS is to increase knowledge-sharing and mutual understanding between two Academic partners, Laboratoire Aimé Cotton (LAC), France and Dipartimento di Fisica of the Università di Pisa (UNIPI), Italy, and one SME, Orsay Physics (OP), France. The technical-scientific focus of this strategic partnership is on the development of a new electron and ion source based on ionized ultra-cold atoms. The use of this revolutionary incident source could create a real breakthrough in the Focused Ion Beams (FIB) or in energy electron source technology with substantial improvements in terms of monochromaticity, brightness and minimum spot size. The joint research project is designed to exploit complementary expertise of the participants and to create synergies between them. Orsay Physics is one of the leading companies in realization and commercialization of FIB and start to commercialized UHV focused electron beam columns, dedicated to surface analysis systems. Thus, the OP team should provide the partners the know-how on the ion/electron optics, electronics and industrial production requirements. OP will also provide the industrialization of a prototype and its commercialization. LAC from the Centre National de la Recherche Scientifique (CNRS), is the co-ordinateur of the project and, as the UNIPI, team is specialized in laser cooling of atoms. The LAC, is also specialist in ultra-cold plasma physics wheras the UNIPI is specialized on nanolithography through laser-cooled atomic beams. Thus, the LAC and UNIPI team should provide to OP the know-how on cold atom technology. The LAC team should develop the sources for Focused Ion and Electron Beams based on cold atom technology, why the UNIPI team should develop an ion source, but capable to be complementary to the LAC one, in particular develop a tool for the 'single ion on demand' implantation.",ultra-COLD gas for the production of a Bright Electron And Monochromatic ion Source,FP7,14 October 2014,15 October 2010,964781.0 COLDNANO,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"COLDNANO (UltraCOLD ion and electron beams for NANOscience), aspires to build novel ion and electron sources with superior performance in terms of brightness, energy spread and minimum achievable spot size. Such monochromatic, spatially focused and well controlled electron and ion beams are expected to open many research possibilities in material sciences, in surface investigations (imaging, lithography) and in semiconductor diagnostics. The proposed project intends to develop sources with the best beam quality ever produced and to assess them in some advanced surface science research domains. Laterally, I will develop expertise exchange with one Small and Medium Enterprise who will exploit industrial prototypes. The novel concept is to create ion and electron sources using advanced laser cooling techniques combined with the particular ionization properties of cold atoms. It would then be first time that 'laser cooling' would lead to a real industrial development. A cesium magneto-optical trap will first be used. The atoms will then be excited by lasers and ionized in order to provide the electron source. The specific extraction optics for the electrons will be developed. This source will be compact and portable to be used for several applications such as Low Energy Electron Microscopy, functionalization of semi-conducting surfaces or high resolution Electron Energy Loss Spectrometry by coupling to a Scanning Transmission Electron Microscope. Based on the knowledge developed with the first experiment, a second ambitious xenon dual ion and electron beam machine will then be realized and used to study the scattering of ion and electron at low energy. Finally, I present a very innovative scheme to control the time, position and velocity of individual particles in the beams. Such a machine providing ions or electrons on demand would open the way for the 'ultimate' resolution in time and space for surface analysis, lithography, microscopy or implantation.",UltraCOLD ion and electron beams for NANOscience,FP7,31 January 2017,01 February 2012,1944000.0 COMAGMAT,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"The project will focus on two areas of research in iron-based systems of biotechnological interest: 1) Nanomagnetism of tissue and recombinant wild-type and mutant ferritins; and 2) Nanomagnetism of silica coated magnetic particle/quantum dot (MP/QD) (γ-Fe2O3 /CdSe) hybrids; and, γ-Fe2O3 solid-silica core-mesoporous silica shell nano-architectures. These systems are of interest due to their broad areas of application in materials, biology and medicine; and as experimental model systems for fundamental studies in magnetism. Magnetic measurements (SQUID) and high and low field Mössbauer spectroscopy, over a wide range of temperature and applied magnetic fields, will probe dynamic magnetic processes in these systems. The process of biomineralization of inorganic compounds on organic substrates in biology is at the center of nanoscience and nanotechnology that seek to emulate nature in the production of new materials. The rigid molecular template of ferritin is the prototypical system for iron biomineralization research, catalyzing space-confined iron nucleation at the nanoscale. The magnetic properties of ferritin have inspired the fast growing field of clinical and medical applications of magnetic carriers (MRI enhancement, targeted drug delivery, cancer hyperthermia therapy, and magnetic relaxation switches for DNA and virus detection, etc.) leading to an intense international effort for the production of bio-compatible and bio-functionalized magnetic core/shell nanostructures. As proposed here, silica encapsulation of nanoparticles provides for water-solubility, biocompatibility and easy surface modification for bio-conjugation. In addition, ferritin and its closely related protein, haemosiderin, are implicated in hemoglobin disorder associated diseases, such as α- and β- thalassemia, a genetic disorder prevalent in the Mediterranean.",Studies in nanoscale magnetism: Core/shell magnetic nano-architectures in biology and materials science.,FP6,31 August 2008,01 March 2007,263707.99 COMANCHE,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"Electronic nanodevices have demonstrated to be versatile and effective tools for the investigation of exotic quantum phenomena under controlled and adjustable conditions. Yet, these have enabled to give access to the manipulation of charge flow with unprecedented precision. On the other hand, the wisdom dealing with control, measurements, storage, and conversion of heat in nanoscale devices, the so-called 'caloritronics' (from the Latin word 'calor', i.e., heat), despite a number of recent advances is still at its infancy. Although coherence often plays a crucial role in determining the functionalities of nanoelectronic devices very little is known of its role in caloritronics. In such a context, coherent control of heat seems at present still very far from reach, and devising methods to phase-coherently manipulate the thermal current would represent a crucial breakthrough which could open the door to unprecedented possibilities in several fields of science. Here we propose an original approach to set the experimental ground for the investigation and implementation of a new branch of science, the 'coherent caloritronics', which will take advantage of quantum circuits to phase-coherently manipulate and control the heat current in solid-state nanostructures. To tackle this challenging task our approach will follow three main separate approaches, i.e., the coherent control of heat transported by electrons in Josephson nanocircuits, the coherent manipulation of heat carried by electrons and exchanged between electrons and lattice phonons in superconducting proximity systems, and finally, the control of the heat exchanged between electrons and photons by coherently tuning the coupling with the electromagnetic environment. We will integrate superconductors with normal-metal or semiconductor electrodes thus exploring new device concepts such as heat transistors, heat diodes, heat splitters, where thermal flux control is achieved thanks to the use of the quantum phase.",Coherent manipulation and control of heat in solid-state nanostructures: the era of coherent caloritronics,FP7,30 April 2019,01 May 2014,1754897.0 COMEDIA,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"Wave propagation in complex (disordered) media stretches our knowledge to the limit in many different fields of physics. It has important applications in seismology, acoustics, radar, and condensed matter. It is a problem of large fundamental interest, notably for the study of Anderson localization. In optics, it is of great importance in photonic devices, such as photonic crystals, plasmonic structures or random lasers. It is also at the heart of many biomedical-imaging issues: scattering ultimately limits the depth and resolution of all imaging techniques. We have recently demonstrated that wavefront shaping –i.e. adaptive optics applied to complex media- is the tool of choice to match and address the huge complexity of this problem in optics. The COMEDIA project aims at developing a novel wavefront shaping toolbox, addressing both spatial and spectral degrees of freedom of light. Thanks to this toolbox, we plan to fulfill the following objectives: 1) A full spatiotemporal control of the optical field in a complex environment, 2) Breakthrough results in imaging and nano-optics, 3) Original answers to some of the most intriguing fundamental questions in mesoscopic physics.",Complex Media Investigation with Adaptive Optics,FP7,31 October 2016,01 November 2011,1497000.0 COMEPHS,National Technical University of Athens,manufacturing,"Conventionally, electronic device functions are generated by combining various materials, in which each material has one particular functionality. With the atomic limit as the ultimate achievable goal in sight, we try to explore methods that do not need extensive use of top-down nanotechnology, including lithography and deposition/etching techniques, but use device structures that are spontaneously created by nature in the general framework of electronic phase separation. Here one material can adopt more than one electronic state, and by judicious organization of these electronic states device functions can be generated with built-in atomic precision. In a number of materials like manganites, a spectacularly diverse range of exotic magnetic, electronic and crystal structures can coexist at different locations on the same crystal. What looks in one sense like awkward complexity is in fact a route toward engineering without the difficulties of atomic scale lithography - by manipulating the propensity of phase separation and phase coexistence in these materials we may make dynamically controlled functional electronic structures. The coexisting phases may form robust magnetic, electronic and crystallographic textures on 'mesoscopic' length scales. By controlling an array of textured phases analogous to those in liquid crystals we may be able to control locally the electronic structure and properties without atomic-scale fabrication. In manganites, for example, a simple domain wall in the ferromagnetic metallic phase could spontaneously develop an insulating barrier of the charge order phase creating the ultimate spin-tunnel junction. COMEPHS is the first European project that aims to concentrate all necessary resources in Europe in order to achieve functionality of mesoscopic textured states. The research aims to provide basis for a new set of electronic technology and COMEPHS is expected to ensure European preeminence in this strategic domain.",Controlling Mesoscopic Phase Separation,FP6,30 November 2008,01 June 2005,3183800.0 COMETNANO,"Centre for Research & Technology, Hellas * Ethniko Kentro Erevnas Kai Technologikis Anaptyxis (CERTH)",energy,"COMETNANO project is an integrated approach of metallic-nanoparticles synthesis, their controlled combustion in internal combustion engines and regeneration of the respective metal-oxides via reduction by renewable means. The main objectives of COMETNANO project are the following: -The production of tailor-made metal fuel nanoparticles with controllable combustion rate. -The utilization of an environmental-friendly way for the regeneration of burned particles (oxides), employing 100% renewable hydrogen produced by solar-thermal dissociation of water in coated monolithic reactors. Under such a concept, metal particles become an energy carrier and a means of converting hydrogen-energy into a medium that can be stored and transported easier and safer. -The innovative exploitation of low-cost raw materials, such as discarded fractions/wastes or by-products of metal industries, for the production of the initial metallic nanoparticles. -The introduction of required modifications, based on the existing mature technology of conventional internal combustion engines (ICEs), for the definition of the first metal-fuelled ICE. -The elimination of NOx emissions by proper combustion tuning. -The investigation of potential environmental and health dangers stemming from metallic and oxidic nanoparticles and the introduction of basic protection measurements. The successful completion of COMETNANO project will provide the necessary answers concerning the feasibility and the environmental benefits of such an innovative concept, thus stimulating the interest of both automotive and metal industries. The COMETNANO consortium consists of 5 organizations from 4 E.U. countries, including 2 Industrial partners, 2 Research Institutes and 1 University.","Technologies for Synthesis, Recycling and Combustion of Metallic Nanoclusters as Future Transportation Fuels",FP7,30 April 2012,01 May 2009,1748404.0 COMHMAT,University of Crete * Panepistimio Kritis,energy,"The efficient storage of hydrogen is the bottleneck in the development of fuel-cell powered vehicles. Currently, technical targets for hydrogen storage capacity have not been met by any existing technology. The European Union has set research needs for hydrogen storage in very high priority in view of the expected benefits of fuel cells in facing the global warming problem. Experimental studies have concluded that a promising method for storing hydrogen is by adsorption in metal-doped porous materials. Physically, in this method, the metal nanoparticles cause dissociation of hydrogen gas and H atoms subsequently migrate to the porous adsorbent. The phenomenon is called spillover and its mechanism is currently not understood. We aim to use a multi-scale modeling approach, consisting of ab-initio DFT calculations, Monte Carlo simulations and macroscopic modeling, in order to: a) Understand the mechanism of spillover and the effects of material properties and operating conditions. b) Quantify the capacity of hydrogen storage by spillover on a variety of metal-doped porous materials, including graphitic materials, carbon nanotubes, carbon foams, graphite-oxide materials, metal-organic frameworks and covalent-organic frameworks) c) Predict materials that would be expected to have high hydrogen storage capacities through the mechanism of spillover.",Computational study of hydrogen storage in metal-doped materials,FP7,31 October 2013,01 November 2009,100000.0 COMMONSENSE,University College Cork,health,"The detection of IED manufacturing facilities is crucial for the security of citizens, as well as infrastructures and utilities. Current sensing methods suffer from susceptibility to false positive results due to environmental contaminants, or false negative results to interfering compounds. The need exists for a single distributed network, with a common interface and communications protocol, to manage and communicate with a variety of different sensor technologies, and use the combined sensor data to produce clear and unequivocal results with low false positive/negative readings. The goal of the CommonSense project is to create and demonstrate this sensor network, through the simultaneous and parallel development of novel materials, portable sensors and a wireless communications network, which uses chemometric data processing algorithms to 'learn' to recognise trace amounts of explosives, and differentiate them from interferents. The partners will produce a series of novel organic, polymeric and nanocrystalline materials with tuned optoelectronic properties and surface affinities to be used as the active sensor elements. These elements will be incorporated into devices based on optical, electrical, and other readout mechanisms, for detection of airborne and waterborne analytes. The CommonSense project will also incorporate radiation detectors to detect this growing security threat of 'dirty bombs', where sub-critical amounts of radioactive materials, obtained from medical waste or other sources, are incorporated into IEDs. The key point in the use of such a variety of sensor technologies is that no one substance can act as an interferent to all of the sensors, thus reducing false positives and negatives. Eliminating the remaining false readings will be achieved through use of the chemometric algorithms in order to teach itself to recognise the 'fingerprint' sensor response to different explosives types and ignore interfering compounds.",Development of a Common Sensor Platform for the Detection of IED 'Bomb Factories',FP7,31 December 2013,01 January 2011,3404935.0 COMMOTION,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The goal of COMMOTION is to establish a strategy whereby functional molecular devices (e.g. photo-/electroactive) can communicate with one another in solution and in organized, self-assembled media (biotic and abiotic). Despite intense research, no single strategy has been shown to satisfactorily connect artificial molecular components in networks. This is perhaps the greatest hurdle to overcome if implementation of artificial molecular devices and sophisticated molecule-based arrays are to become a reality. In this project, communication between distant sites / molecules will be based on the use of photoejected ions in solution and organized media (membranes, thin films, nanostructured hosts, micellar nanodomains). Ultimately this will lead to coded information transfer through ion movement, signalled by fluorescent reporter groups and induced by photomodulated receptor groups in small photoactive molecules. Integrated photonic and ionic processes operate efficiently in the biological world for the transfer of information and multiplexing distinct functional systems. Application in small artificial systems, combining 'light-in, ion-out' (photoejection of an ion) and 'ion-in, light-out' processes (ion-induced fluorescence), has great potential in a bottom-up approach to nanoscopic components and sensors and understanding and implementing logic operations in biological systems. Fast processes of photoejection and migration of ions will be studied in real-time (using time-resolved photophysical techniques) with high spatial resolution (using fluorescence confocal microscopy techniques) allowing evaluation of the versatility of this strategy in the treatment and transfer of information and incorporation into devices. Additionally, an understanding of the fundamental events implicated during the process of photoejection / decomplexion of coordinated ions and ion-exchange processes at membrane surfaces will be obtained.",Communication between Functional Molecules using Photocontrolled Ions,FP7,31 August 2013,01 September 2008,1250000.0 COMOSYEL,IMEP-LAHC Laboratory,photonics,"COMOSYEL aims at designing complex nanometric and molecular systems to process electronic or optical information from the macroscopic to the molecular scale. It proposes two specific, unconventional approaches to molecular electronics and plasmonics and the development of two multidisciplinary technical toolkits, one in bio-inspired chemistry and one in surface nanopatterning by liquid nanodispensing that will support the first two topics, and eventually become a part of the team's culture for future research developments. (1) Graphene-based nanoelectronics is an experimental implementation of mono-molecular electronics concept using graphene to bridge the macroscopic world to the molecular scale. This topic aims at encoding and processing electronic information in a single complex molecular system in order to achieve complex logic functions. (2) Self-assembled nanoplasmonics aims at developing a molecular plasmonics concept. Here, complex networks of sub-20nm crystalline metallic nanoparticle chains are produced and interfaced to convert photons to plasmons and ultimately confine, enhance and route light energy from a conventional light source to an arbitrary chromophore on a substrate. (3) Bio-inspired nanomaterials chemistry will be the main synthetic tool to produce new multifunctional nanostructured materials able to address and collect information from/to the macroscopic world to/from the single molecule level. Both morphogenesis and self-assembly will be explored to better control size and shape of nano-objects and the topology of higher-order architectures. (4) Liquid nanodispensing is a promising tool to interface nanosized/molecular sized systems with both lithographically produced host structures and individual molecular systems. A nanoscale liquid dispensing technique derived from AFM combines resolution and versatility and will be pushed to its extreme to master the deposition of nanoobjects onto a substrate or a precise modification of surfaces.",Complex Molecular-scale Systems for NanoElectronics and NanoPlasmonics,FP7,31 December 2013,01 August 2008,1439712.0 COMP. SPINTRONICS,Juelich Research Centre * Forschungszentrum Jülich,information and communications technology,"Spintronics, in which electronics and magnetism are combined, is attaining an increasing amount of interest due to its potential in applications. The proposed project focuses on searching for novel materials aimed for future applications in spintronics using state-of-the-art computational methods. The emphasis is put on finite temperature properties using Monte Carlo simulations and on electronic correlations using the dynamical mean field theory and density functional calculations, as implemented in the Korringa-Kohn-Rostoker (KKR) method. These methods will further be developed on the IBM Blue Gene supercomputer at the Research Center Julich. During the previous work the researcher has established his expertise in many areas of magnetism, including diluted magnetic semiconductors, magnetic multilayers, noncollinear magnetism and in statistical methods. With the proposed project the researcher shall complete his knowledge about magnetism and will learn more about electronic structure theory. He will learn a completely new field of strongly correlated systems. The interest in strong correlations in magnetic systems is increasing rapidly so that the researcher shall benefit a lot from the methods and problems that he will learn. The stay in Germany should create many new contracts for the researcher that will help him in his future work. The complementary skills like increased responsibility and independence of the research are very important in promoting further the scientific career of the candidate. The aspects of transnational mobility will result in the information exchange between Sweden and Germany and help in developing the European research area.",Computational Spintronics,FP6,07 January 2009,08 January 2007,142350.0 Compact,Sanofi-Aventis Deutschland GmbH,health,"Most biopharmaceuticals (BP) currently on the market are recombinant proteins which are parenterally administered. These would benefit from more patient-friendly routes of administration. Moreover, new classes of BP (e.g. siRNA, miRNA, DARPins) with specificity for intracellular targets hold promise but await the advent of efficient delivery systems before their potential can be realised into therapeutic products. Solving the bottleneck of BP delivery is one of the main incentives of the pharmaceutical industry as this would allow a broadening of the spectrum of potential targets for therapeutic intervention needed to fill their drug pipelines. COMPACT represents Europe's frontrunners in pharmaceutics, nanotechnology, biology, chemistry, engineering and imaging who will work in close collaboration with EFPIA on the delivery issues with BP. The main objectives are (1) to identify and understand transport pathways across biological barriers and cell membranes that can be utilized for delivery of BP, (2) to c",Collaboration on the Optimisation of Macromolecular Pharmaceutical Access to Cellular Targets,FP7,31 October 2017,01 November 2012,1.0184909E7 COMPASS,Lund University * Lunds Universitet,manufacturing,"Self-assembly is the key construction principle that nature uses so successfully to fabricate its molecular machinery and highly elaborate structures. In this project we will follow nature’s strategies and make a concerted experimental and theoretical effort to study, understand and control self-assembly for a new generation of colloidal building blocks. Starting point will be recent advances in colloid synthesis strategies that have led to a spectacular array of colloids of different shapes, compositions, patterns and functionalities. These allow us to investigate the influence of anisotropy in shape and interactions on aggregation and self-assembly in colloidal suspensions and mixtures. Using responsive particles we will implement colloidal lock-and-key mechanisms and then assemble a library of “colloidal molecules†with well-defined and externally tunable binding sites using microfluidics-based and externally controlled fabrication and sorting principles. We will use them to explore the equilibrium phase behavior of particle systems interacting through a finite number of binding sites. In parallel, we will exploit them and investigate colloid self-assembly into well-defined nanostructures. Here we aim at achieving much more refined control than currently possible by implementing a protein-inspired approach to controlled self-assembly. We combine molecule-like colloidal building blocks that possess directional interactions and externally triggerable specific recognition sites with directed self-assembly where external fields not only facilitate assembly, but also allow fabricating novel structures. We will use the tunable combination of different contributions to the interaction potential between the colloidal building blocks and the ability to create chirality in the assembly to establish the requirements for the controlled formation of tubular shells and thus create a colloid-based minimal model of synthetic virus capsid proteins.",Colloids with complex interactions: from model atoms to colloidal recognition and bio-inspired self assembly,FP7,01 July 2021,02 January 2014,2498040.0 COMPASS,Seagate Technology Ireland Ltd.,photonics,A remarbable convergence between the magnetic hard-drive industry and photonics technology is about to take place through the use of lasers to switch magnetisation at the nanoscale using plasmonics powered by a semiconductor laser. This heat assisted magnetic recording will enable storage densities of 1 terabit per square inch. The laser needs to be integrated with the read-write head and needs to operate under severe temperature conditions. The implementation of lasers in manufactured products requires the attainment of new knowledge by the magnetics industry along with the response of the academic industry to the new performance challenges. These goals can only be reached through a strong collaborative programme between industry and academia. The scientific programme is to study the properties of III-V materials to allow higher temperature operation and to study the reliability of lasers when formed by etching. The knowledge will be transferred through the cross-border secondment of staff and researchers between Seagate and the Tyndall National Institute.,Convergence of magnetics and plasmonics through semiconductors,FP7,31 December 2015,01 January 2012,816738.0 COMPLEXLIGHT,National Research Council * Consiglio Nazionale delle Ricerche (CNR),photonics,"The project is aimed at funding a multi-disciplinary laboratory on nonlinear optics and photonics in soft-colloidal materials and on 'complex lightwave systems'. A team of talented young researchers, divided among experiments, theory, parallel computation and nano-fabrication is involved. The proposed research will foster several breakthrough discoveries from soft-matter to biophysics, from nonlinear and integrated optics to the science of complexity and cryptography. The underlying vision is driven by the physics of complex systems, those displaying a large number of thermodynamically equivalent states and emergent properties. There are 4 original and high-impact activities, which explore applicative potentialities: 1) sub-wavelength light filaments in soft- and bio-matter; 2) lasers in soft-matter and bio-tissues; 3) control of soft-matter lasers by light filaments; 4) complex lightwave systems, encryption by nano-structured disordered lasers. Activity 1 will lead to ultra-thin re-addressable light beams (sub-wavelength spatial solitons) propagating in soft- and bio-matter that can be used in laser-surgery, matter manipulation and able to guide high power laser pulses; activity 2 attains novel structural diagnostic techniques in bone tissue surpassing limits of nuclear magnetic resonance imaging, and assesses the field of lasers in soft-materials; activity 3 will demonstrate the control of self-organization processes in soft-matter by light filaments probed by laser emission; activity 4 is based on specific features mutuated from spin-glass theory, and will realize a novel cryptographic technique superior to chaotic systems in terms of security. Activity 1 and 2 are propaedeutic to the others. The team is composed by the Principal Investigator (P.I.), 4 post-doctoral researchers and 3 Ph.D. students. The budget will be used for paying the P.I., two post-doctoral positions, laser sources, high performance computing facilities, and instrumentation.",Light and complexity,FP7,30 April 2013,01 May 2008,1085000.0 COMPLEXPLAS,University of Stuttgart * Universität Stuttgart,photonics,"Nano-optical investigations using plasmonic resonances have revolutionized optics in the last few years. The ability to concentrate light in subwavelength dimensions and to locally enhance the strength of the electromagnetic field in a tailored fashion opened several new fields in materials research, such as tailoring the linear and nonlinear properties of optical materials at will. So-called metamaterials allow now to design and realize unprecedented optical properties on the submicrometer level and hence tailor dispersion as well as real and imaginary parts of the linear and nonlinear refractive indices as a function of wavelength and wavevector. Our ability to create two- and three-dimensional nanostructures with advanced fabrication technologies have led to the new era of complex plasmonics. We are able to tailor the spectral response of complex metallic nanostructures, including the creation of very sharp and narrow resonances. In combination with strong field localization and hence large dependence on the material properties of the nanostructure geometry and its surrounding, unique sensors with sensitivities close to fundamental limits should be within reach. In my proposal, I would like to explore the ultimate limits of light-matter interaction using complex plasmonic nanostructures. I would like to apply them to different physical, chemical, and biological situations and undertake the first steps from fundamental insight into first applications. Namely, I would like to investigate complex plasmonics in four different contexts: single molecule reactions on complex surfaces, antenna-enhanced structural analysis of large single molecules, such as proteins, motion sensing of conformational changes of single molecules, as well as chiral sensing down to the single molecule level, hence ultimately being able to distinguish a single D-glucose molecule from its L-glucose enantiomer. This would bridge the gap between nanophysics, chemistry, and biology.",Complex Plasmonics at the Ultimate Limit: Single Particle and Single Molecule Level,FP7,28 February 2018,01 March 2013,2000000.0 COMPNANOALD,University of Helsinki * Helsingin Yliopisto,manufacturing,"During the fellowship, novel, beyond the-state-of-the-art complex nanostructures will be prepared by atomic layer deposition (ALD). ALD is based on successive, alternating surface controlled reactions from the gas phase to produce thin films in the nanometer range with perfect conformality, process controllability and precise control of film thickness. In this project, four complex nanocomposites and nanoreplicas will be prepared: (1) Semiconductor oxide core-shell structures (WO3 nanotube core with TiO2 oute shell) will be prepared for photocatalysis. It will be investigated, how the photocatalytic activity can be tuned by the thickness of the outer TiO2 layer. (2) Carbon nanotube (CNT) – multilayer semiconductor oxide (SnO2, In2O3, TiO2) core-shell structures will be prepaped for selective gas sensing at room temperature. The effect of composition and thickness of semiconductor oxide outer shells on gas sensing will be explored. (3) 2D and 3D Al2O3 nanotubes will be prepared by using a template with 2D and 3D nanoholes. After removing the template, the 2D and 3D nanotubes will be set free. (4) The TiO2replica of biological structures (lotus leaf) with a complex nanostructured surface will be prepared. The hydropobic and photocatalytic features of the as-produced multifunctional material will be tuned by its thickness. The new nanomaterials and new preparation approaches have a high potential to lead to new products and technologies. The training objective of the fellowship is to provide the fellow the neccessary skills to start a new ALD research group. A thourough theoretical and practical training on ALD will be obtained (planning and conducting ALD experiments, analytical tools for characterizing ALD films, listening to courses on ALD and nanotechnology). Supplementary skills will be also provided (managing an ALD laboratory, conference organizing, supervising BSc and MSc students, oral and written presentation, knowledge of Finnish language).",Preparing Complex Nanostructures by Atomic Layer Deposition,FP7,02 February 2013,02 March 2011,184759.18 COMPNANOCOMP,Dutch Polymer Institute (DPI),environment,"This project aims at the development of multiscale simulation methodology and software for predicting the morphology (spatial distribution and state of aggregation of nanoparticles), thermal (glass temperature), mechanical (viscoelastic storage and loss moduli, plasticity, fracture toughness and compression strength), electrical and optical properties of soft and hard polymer matrix nanocomposites from the atomic-level characteristics of their constituent nanoparticles and macromolecules and from the processing conditions used in their preparation.",Multiscale computational approach to the design of polymer-matrix nanocomposites.,FP7,09 June 2016,10 January 2011,0.0 COMPONLO,National Hellenic Research Foundation * Ethniko Idryma Erevnon,photonics,"The boost development of pioneering optoelectronic devices creates the need for powerful non-linear optical materials. Recently, the combination of metal nanoparticles with carefully designed polymers pointed out that it is possible to create composite materials with orders of magnitudes enhanced non-linear optical activity. However, no systematic studies yet exist on the parameters that influence the composite's non-linear optical properties yet. In the presented project, the systematic study of those parameters is proposed. The implementation of the proposal involves the synthesis of well-designed polymers and metal nanoparticles as well as their combination in the form of thin films with the desired structural characteristics. Subsequently, the non-linear optical properties of the films will be measured and the results will be interpreted under the prism of the films' structural characteristics. A number of parameters is proposed to be elucidated, such as metal nanoparticles concentration, disposition and surface plasmon resonance, interaction between polymer and nanoparticles, film thickness, etc. The outcome of the project is expected to establish certain guidelines for the design of effective non-linear optical materials, suitable for advanced technologies.",Polymer / metal nanoparticles composites with enhanced non-linear optical properties,FP7,28 February 2014,01 March 2011,45000.0 COMPOSE,Centre for Materials and Coastal Research * Helmholtz-Zentrum Geesthacht – Zentrum für Material- und Küstenforschung GmbH,health,"It is the objective of COMPOSE to develop new materials with predefined physical and chemical characteristics. The membranes developed will be based on new understanding of materials phenomena, especially in the nano range. COMPOSE focuses on the development of novel nanostructured materials for selective transport and separation. Two classes of materials will be developed in this project: nanostructured organic/inorganic hybrid materials and functional self organized supramolecular copolymers. Organic/inorganic hybrid materials will be developed and manufactured into membranes for the selective separation of gases and liquids. During this development, new knowledge will be gained about the behaviour of composite organic/inorganic membranes, where the inorganic phase is composed of nano-particles.Among the materials to be developed are high free volume polymers filled with in-situ generated inorganic phases and mixed matrix membranes consisting of polymer and dispersed carbon molecular sieve flakes. Exceptional gas fluxes and selectivities are expected. Organic/inorganic hybrid membranes will also be developed for nanofiltration in organic solvents. The membranes envisaged can have enormous economic benefit for the chemical and pharmaceutical industry. The second route to totally new membrane materials is the self organisation of block copolymers. Self- organisation is an important building principle of biological membranes. Building membranes by the same principle tries to imitate nature, even so the molecules used for synthetic membranes are very different from biological ones. This part of COMPOSE dealing with creating membranes by molecular self-assembly promises a new paradigm in membrane technology and knowledge. Totally new membrane structures will emerge from this research opening the door to new applications. One objective is the development of a novel type of a charged mosaic membrane.",Multicomponent nanostructured materials for separation membranes,FP6,28 February 2007,01 March 2004,1829719.0 COMPOSE3,IBM Research GmbH,information and communications technology,"COMPOSE3 aims to develop 3D stacked circuits in the front end of line of Complementary Metal Oxide Semiconductor (CMOS) technology, based on high mobility channel materials. The final objective is a 3D stacked SRAM cell, designed with gates length taken from the 14nm technology node. This technology will provide a new paradigm shift in density scaling combined with a dramatic increase in the power efficiency of CMOS circuits. Our synergistic approach is based on the use of high mobility channel materials such as SiGe and InGaAs, utilized in fully depleted metal-oxide-semiconductor field effect transistor (MOSFET), for p and n channel MOSFETs respectively. The low processing temperatures (<600ºC) that can be used for high mobility channels are indeed advantageous for an intimate 3D stacking. COMPOSE3 also exploits the knowledge accumulated in Europe for the layer transfer of ultra-thin semiconductors. Wafer bonding and layer transfer is a critical process module that will be used to enable 3D stacking of high mobility channels. The overall objectives of COMPOSE3 will address the substrate, device and circuit issues. One objective will be to validate InGaAs layer transfer for implementation on 300mm wafers. Another objective will be to benchmark InGaAs nFETs with relevant contact dimensions against planar and non-planar Si based solutions at the 14nm node and beyond. The final objective will be to integrate, on 300mm wafers, monolithic 3D CMOS circuits with 14nm node gates based on n-type InGaAs devices on top of p-type (Si)Ge devices which are independently optimized. COMPOSE3 is extremely well aligned with the strategic agenda of the leading European IC manufacturer, and also exploits its innovation for the benefit of a European SME. It gathers the main European leaders in the advanced nanoelectronics R&D arena.",Compound Semiconductors for 3D integration,FP7,10 July 2018,11 January 2013,3195303.0 COMSON,University of Wuppertal * Bergische Universität Wuppertal,information and communications technology,"Performing the step from micro- to nanoelectronics, the semiconductor industry is confronted with very high levels of integration introducing coupling effects that were not observed before. The complexity of this problem is beyond the possibilities of the software and design environments used within the microelectronics industry at present. Furthermore, it places additional requirements on the researchers of the future, since they must be able to understand all aspects of the problems faced by the industry. To meet these new scientific and training challenges, the COMSON consortium on 'Coupled Multiscale Simulation and Optimization in Nanoelectronics' merges the know-how of the three major European semiconductor industries with the combined expertise, in all fields of interest, of specialized university groups for developing adequate mathematical models and numerical schemes, and realizing them in a common demonstrator platform: on the one hand, to test mathematical methods and approaches, so as to assess whether they are capable of addressing the industry's problems; on the other hand, to adequately educate young researchers by obtaining immediate hands-on experience for state-of-the-art problems.",Coupled Multiscale Simulation and Optimization in Nanoelectronics,FP6,31 March 2010,01 October 2005,2294900.0 COMTRANS,Leibniz Institute for Solid State and Materials Research Dresden * Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden eV,information and communications technology,"Impending nanotechnological revolutions will create a variety of novel approaches to addressing scientific and technological challenges in our society. The research and application of nanosized materials will be a major scientific and technological goal of the 21st century.Single wall carbon nanotubes (SWNTs) represent the one dimensional form of carbon and can be imagined as a rolled up sheet of graphene with a diameter in the nanometer range and a length of up to several hundred microns. All physical properties of a SWNT are determined by the diameter and the angle of rolling up relative to the graphene lattice, also known as the chiral angle. Resonance Raman spectroscopy on SWNTs has recently reached a level of understanding, where the diameter and chirality can be determined by the position and the intensity of the radial breathing mode of the SWNT.In this project we propose the combined measurement of resonance Raman spectra and electronic transport properties on the same functionalised nanotube device with the goal to investigate the role of chirality and functionalisation in electronic transport.The Raman and transport measurements will be carried out in field effect transistor geometry in order to tune the Fermi level as a function of gate voltage. The electronic transport will also be studied as a function of external fields (e.g. photoconductivity).",Combined resonance Raman and transport studies of functionalized carbon nanotubes,FP6,30 June 2008,01 July 2006,156496.0 CONAT,Technion Israel Institute of Technology,information and communications technology,"Silicon-based technologies are approaching their physical limits, and technology breakthroughs, in terms of materials and processes, will be required as device sizes reach the nano-scale frontier. To face these challenges, a new generation of devices based on a clever combination of selected materials is currently under consideration worldwide. The aim of this project is to investigate the conduction mechanisms, in connection with degradation and breakdown characteristics, of Metal Gate/High-K structures on III-V substrates intended for applications in future MOS transistors. This aspect is primary obstacle to the successful incorporation into mainstream semiconductor process. To the date, no systematic study about these topics in such advanced structures has been carried out.",Conduction Mechanisms in Advanced MOS Technologies,FP7,08 July 2016,09 January 2012,0.0 CONCEPT,TWI Ltd.,energy,A novel portable Nanofocus Computed Tomography PCT system will be developed to perform total structural integrity inspection of present and next generation composite wind turbine blades without taking them out of service The COncEPT system will provide the only means of detecting significant defects including nanowidth disbonds in the thickest sections of the 100m length blades intended in the future As a diagnostic tool to assure the safe operation of present and future wind farms it will provide the key enabling technology to support the growth of wind power intended under global economic environmental and societal policy initiatives Continued increase in the size of turbine blades necessary to meet power generation efficiency targets for wind power may produce enhanced environmental fatigue and impact damage effects of an order as yet unknown and the highest sensitivity of structural health monitoring as provide by COncEPT will be required to address this The use of WTs has increased at approximately 30 per annum from 1993 and this is set to continue until 2010 consistent with world wide initiatives for sustainable and renewable energy sources Composite materials are essential to realise these targets efficiently However a small discontinuity in a composite material can seriously impair its in service function and may lead to a critical fault with little or no visible sign Failure to detect such a fault can and has resulted in catastrophic failure endangering life and reducing public confidence leading to restricted future WT developments The need to detect such small defects in the thickest sections of wind turbine blades is only feasible by means of radiography with a nanofucus tube and CT image reconstruction routine The project will increase the competitive advantage of European SMEs enabling them to increase their share of the 600m global inspection market The estimated minimum return on investment ratio is 131 1 see B3 1,Development of a Portable High Energy Nanofocus Computed Tomography system for Glass Reinforced Plastic Wind Turbine Blades,FP6,30 November 2008,01 December 2006,1130217.0 CONCEPTGRAPHENE,Chalmers University of Technology * Chalmers Tekniska Högskola,information and communications technology,"The concept of this project is to unlock the potential of epitaxial graphene on silicon carbide (SiC) for development of scalable electronics with the view to develop graphene-based devices & circuits with a non-conventional functionality. Our strategy is to explore two promising directions of graphene-based technology: (i) the development of large-scale graphene wafers for manufacturing high-density of devices on a single SiC wafer, and (ii) the development of hybrid circuits for applications of graphene in spintronics and metrology by exploiting the flexibility for design offered by the large area of graphene on SiC. The consortium of bidders brings together groups with complementary expertise and substantial achievements in the relevant area of graphene research and nanotechnology in general.",New Electronics Concept: Wafer-Scale Epitaxial Graphene,FP7,09 June 2015,10 January 2010,0.0 CONIA,Technische Universiteit Delft * Delft University of Technology,energy,"Fuel cell systems are high-efficiency, low-emission energy conversion modules for transportation, stationary and portable applications. Especially for automotive applications, low-temperature proton exchange membrane (PEM) fuel cells are considered a key-stone solution, as they can effectively reduce greenhouse gases emissions. A major barrier for the market penetration of these systems is the material scarcity of precious metals used for the fabrication of the electrocatalyst, a core-component of the system. Achieving increased performance in terms of catalytic activity and stability (corrosion resistance) while decreasing the cost, can be realized by a drastic redesign of the catalyst fabrication process using Atomic Layer Deposition (ALD) of nanoparticles. Using the understanding of the ALD coating processes obtained in the ERC-StG project AggloNanoCoat, the technique's potential for producing tailored yet inexpensive core/shell nanoparticles for advanced catalysis applications has been identified. The innovative process characteristics (precise surface modification, mild operating conditions, scale-up potential and minimization of environmental footprint) clearly form a strong pre-commercialization starting-point. The next required step is the assessment of the market potential, effectively bridging nanoparticle ALD and the fuel cell catalyst manufacturing section. The CONiA project will establish the basis for commercial development by introducing an attractive communication package based on the outcomes of a validation case-study. The main objective of the activities will be to demonstrate the scale-up potential and provide an initial costing structure for the future venture. In parallel, a solid business proposition will be set, to enable the consecutive required actions for securing further funding and to provide the corner-stone for kick-starting a company that will commercialize the technology.",Core/Shell nanoparticle electrocatalysts for fuel cell applications: probing the market potential of Atomic Layer Deposition (ALD) coatings,FP7,31 October 2014,01 May 2013,147872.0 CONQUEST,Stichting Katholieke Universiteit * Catholic University Foundation,health,"The success of modern medical treatments such as cellular therapy and targeted treatments requires appropriate tools for in vivo monitoring. Imaging modalities, such as magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT) and positron emission tomography (PET) are key candidates due to their noninvasive nature. However, these imaging techniques are extremely expensive and can involve radiation, both of which hinder their longitudinal and repetitive use. Ultrasound has so far been unsuitable due to the absence of a label to differentiate regions of interest from tissue background, the main problem being that current ultrasound contrast agents (CAs) have active lifetimes in the order of minutes. The CoNQUeST platform (Clinical Nanoparticles for Quantitative Ultrasound with high STability) proposed here is an entirely new type of ultrasound CA that is extremely stable (lifetime of a year) and is not affected by insonation. This mechanism of contrast generation appears completely novel: The polymeric particles are under 200nm in diameter and must contain a soluble metal (M.Srinivas et al., patent pending, filed 09/2012). Based on the current state of the art, these particles are too small and do not contain the requisite gaseous component for ultrasound contrast. CoNQUeST particles are applicable to longitudinal and repeated imaging, as is necessary for cell tracking, due to their stability. Furthermore, these particles can be chemically bound to targeting agents, dyes and drugs, and are suitable for multimodal imaging, including MRI (both 1H and 19F), fluorescence and SPECT. Finally, the CoNQUeST agents are suitable for clinical use. I propose the application of the CoNQUeST agents to a clinical trial for tracking dendritic cell therapy in melanoma patients, longitudinal theranostic imaging in preclinical models and thorough characterisation of this novel mechanism of ultrasound contrast generation.",Clinical ultrasound platform for the quantitative and longitudinal imaging of theranostics and cellular therapy,FP7,31 March 2018,01 April 2014,1199882.0 CONSIST,Wroclaw University of Science and Technology * Politechnika Wrocławska,manufacturing,"Closed down, but outstanding examples of industrial monuments have to be considered as important witnesses of our cul- ture. New preservation strategies are requested for large outdoor monuments, being heavily corroded and mechanically endangered. The project will concentrate on the comparative testing of established traditional, modern, and within the pro- ject developed new surface conservation materials and preservation strategies for industrial heritage made of iron and steel. The laboratory tests will require the application of suitable transparent compounds like traditional oils and waxes, comparing them with micro-crystalline waxes, modern resins like acrylics or epoxy-functionalised lacquers, and newly de- veloped coatings such as the combination of isocyanato-based polyacylate dispersions (as silanes) and hybrid polymeric sols, leading to advanced hybrid systems by nano-scaled sol-gel preparation techniques. Room-temperature curing will be obligatory for its applications. The influence of different degrees of surface cleaning on the protective effect of the coatings will be specified. The conservation material development will respect standards set by conservation ethics, focussing on the reversibility and re-treatability of transparent coatings. The newly developed systems will be water-based and thus provide an alternative to solvent-based lacquers and natural resins available so far. Pilot applications of the most promising coatings on three selected objects in Ireland, Poland, and Germany will be performed to compare the advanta- ges of the new materials with the commercially available systems. Management concepts for industrial heritage sites will be established to demonstrate the potential for economic growth through the application of new methodologies. The pro- ject team consists of five contractors and two subcontractors, including research institutes, universities, public authorities and a strong participation of SMEs.",Comparison of conservation materials and strategies for sustainable exploitation of immovable industrial cultural heritage made of iron and steel,FP6,31 May 2008,01 June 2005,870050.0 CONSTANS,NWO - FOUNDATION FOR FUNDAMENTAL RESEARCH ON MATTER (FOM),photonics,"In the last decade, the fields of nanoplasmonics and photonic crystals have opened up the nanoscale for optical control. Both the flow and emission of light can be controlled at these small length scales, giving rise to new science and applications. Interestingly, freely propagating light beams can already contain nanoscale features, i.e. optical singularities. Little is known about this nanoscale structure of light. I propose to (1) reveal the structure of light at the nanoscale and its interaction with geometrical structures or other light structures; and (2) achieve full spatio-temporal control of the nanoscale structure of light. Crucial to achieving these goals are technological innovations, which will be crosscutting objectives. These include the first nonlinear vectorial scanning near-field microscope and novel near-field probes allowing access to new combinations of vector fields. This next step in the field of nano-optics is possible due to recent breakthroughs in the control and visualization of light at the nanoscale obtained in my group. I will combine newly acquired access to the vectorial nature of light with its active control to investigate how (deep-) subwavelength structures of light of different frequencies affect each other when coupled through a nonlinear interaction in a nanostructured material. In parallel I will focus on optical singularities. Because of their extreme size, small changes in their position will lead to huge effects in the local light fields, opening up potential for all-optical and therefore ultrafast control. The research will lead to innovations in the visualization and control of light at the nanoscale, access to the magnetic component of light, nanoscale nonlinear optics and coherent control of light fields. The knowledge gain will be crucial for applications like ultrasensitive biosensors based on superchiral light, ultrafast magneto-optics and nanoscale quantum optics.",Control of the Structure of Light at the Nanoscale,FP7,28 February 2019,01 March 2014,2493600.0 CONSTGLASS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,environment,"Since about 1950 various materials have been propagated for the conservation of stained glass, including epoxy resins, acrylates and polyurethanes. For all conservation materials on stained glass there is a substantial lack of assessment of treatments after decades of natural weathering. Since most of the applied materials cause problems nowadays, the introduction of innovative and promissing new preservation strategies and materials are necessary. The aim of this project is to secure the conservation of stained glass windows as an important part of our European cultural heritage. Therefore, the proposal has been conceived with the following objectives: - to evaluate a representative variation of conservation materials on selected original objects after natural weathering; - to optimise and apply advanced non-destructive analytical methods and molecular biological tools for understanding long-term effects of conservation treatments and biodeterioration; - to investigate the degree of reversibility of ancient materials; - to propose remediation strategies based on treatments and re-treatability tests with modern materials and to improve preservation strategies by indroducing innovative conservation materials based on nano-porous glass phases, derived from colloidal silica sols and stabilised by glass fibre components (glass-in-glass consolidants). The pilot objects have been chosen in five different European countries, providing different restoration history and including both, medieval windows as well as objects from the 19th/20th century. Apart from classical analytical methods (optical microscopy, IR, SEM) advanced non-destructive methods (confocal micro-Raman spectroscopy, microfocus and phase contrast X-ray tomography, mCT) and biochemical methods will be applied. The project team consist of eleven partners from seven countries, including research institutes, universities, public authorities and SMEs.","Conservation materials for stained glass windows - assessment of treatments, studies on reversibility, and performance of innovative restoration strategies and products",FP6,31 May 2010,01 June 2007,741900.0 CONT-BECS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),manufacturing,"Nanostructured functional materials constitute one of the most dynamic and rapidly expanding fields in scienceand technology, which include their use in such diverse areas as materials technology, biotechnonology, energyand environmental technology, electronics, catalytic applications etc. From other side, the increasingly importantrole in biophysics and in life sciences is played by laser spectroscopie methods. The present project challengesone of the most exciting and phenomena rich sub-fields of nano-science and nano-technology (N&N): theinteraction of visible and near visible light with nanostructured materials. It is aimed at fabrication of optically-active synthetic nanostructures for the exploration of sensing mechanisms with biological matter.In the framework of the present project research activity is planned to be concentrated on, firstly, deliberatefabrication of optically-active substrate by means of state-of-the-art nanofabrication techniques (e-beamlithography, colloidal lithography etc.) and, secondly, exploration of obtained optically-active substrates forbiosensing applications. Utilizing shaped metallic nanostructures or arrays of metallic nanostrctures to influencethe fluorescence of biomolecules in close proximity to the surface is planned by tuning surface plasmonresonance energy of formed nanoarchitectures. Controlled positioning of macromolecular species on the pre-fomed nobel metal nanostructures to probe enhanced fluorescence or enhanced quenching, necessary for ultra-sensitive detection scheme, will be performed. Later goal constitutes a demostration of sensitivity of builtarchitectures to the binding events between preformed sensing platform and biomolecular species,complementary to those available in the fabricated synthetic bio-nanoarchitectures.Overall, the results of research activity are expected to contribute substantially in fundamental understanding ofsurface enhancement#",Evaporative of a guided atomic beam: towards a continous Bose-Einstein condensate source.,FP6,30 November 2006,01 December 2004,159353.0 CONTEX-T,Center Scientifique & Technique of the Belgian Textile Industry * Centre Scientifique & Technique de l'Industrie Textile Belge,construction,"This project aims at transforming the traditional resource-drive textile industry into a knowledge-based, sustainable and competitive industry by creating breakthrough innovation in a high tech area in technical textiles for construction. Because this area is a driver for innovation it will create significant spill-overs to other important textile technological areas such as, but not limited to, protective clothing, automotive textiles, textile for transportation #Amp; packaging, fibre reinforced structural elements, upholstery materials?. It addresses the development of radically new concepts and new knowledge in multi-functional technical textiles materials using nanotechnology, nano-structured materials and bio-mimic principles. Following a holistic approach, this project aims at developing a breakthrough in textile architecture, lightweight textile reinforced structures and tension fabric structures industry (textile buildings for short). Building with textiles has an industrial potential, the like of which we only expect for the building material glass. The technology which will be developed in this project will lead to textile buildings of the future which will combine creativity and aesthetics with multi-functional, resource-conserving materials utilization, short construction periods, long life and low costs and will lead to a new building technology for safe, healthy and comfortable shelters. The research will focus on the development of lightweight walls and façade elements, lightweight but strong textile cables and belts, thick and thin wall textile materials which provide protection against rain, wind, provide thermal insulation, noise insulation.",Textile Architecture - Textile structures and buildings of the future,FP6,31 August 2010,01 September 2006,6188920.0 CONTROLLED RELEASE,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"The growing demand in food, personal care, agriculture, and pharmaceutical industries for new encapsulation techniques with defined release mechanisms of active ingredients is addressed in this proposal. Encapsulation can be obtained by nano- and micron-sized capsules with well-defined barrier properties where the release of the encapsulants could be controlled by the permeability of the diffusion barrier or by multiple barriers. The most promising way to construct such devices are self-assembly processes on spherical interfaces (droplets) resulting in capsules with tunable permeability. Due to the small size of the capsules, confinement effects on internal phase separation and structuring are important and can be additionally used to control release properties. To facilitate a major breakthrough in the design and utilization of release systems we will use a newly developed class of capsules, based on colloidosomes and bio-polymersomes. However, the complexity and the lack of understanding of the underlying fundamental physical principles of both self-assembly at fluid-fluid interfaces, and release processes, have hampered until now the progress in the design of new encapsulating devices. The overall objective therefore is to 1) develop a generic understanding of self-assembly of nano- and mesostructures at interfaces, and to 2) generate a major breakthrough in design and production of controlled release products for the SME-intensive food, pharmaceutical, and agricultural industries. The multidisciplinary action of physical sciences, engineering, and industrial users in the consortium is unique in the area of self-assembly and its subsequent application, and is absolutely essential to achieve a major breakthrough in developing high value multifunctional materials. The project contributes to the European Union's objectives to move towards a sustainable knowledge-based industry, and the societal objectives of quality of life, health, safety, and environment.'",New controlled release systems produced by self-assembly of biopolymers and colloidal particles at fluid-fluid interfaces,FP6,31 December 2009,01 January 2007,1450000.0 COOL,King's College London,energy,"There is great hope to tackle serious global issues related to energy consumption and waste by developing technologies based on efficient nanoscale materials and devices. For this to happen, we need breakthroughs in our ability to control electrical and thermal transport at the nanoscale. Ab-initio materials modelling will play a central role in this, providing microscopic understanding and the materials parameters needed to bridge the macroscopic performance and the microscopic mechanisms that determine transport properties. In this project I will use ab initio techniques based on density-functional theory to calculate the electronic and vibrational properties of materials as well as the carriers' relaxation times due to carrier-carrier and carrier-defect interactions. These are the key ingredients that will then be used in the Boltzmann transport equation to simulate transport in devices, taking into full account the coupled electron-phonon dynamics in complex geometries, and in the presence of interfaces or defects. The research will proceed in three main directions. First, toward engineering materials and devices for high-performance nanoelectronic applications. Here I will study the detailed mechanisms of carrier-induced heating in silicon- and carbon-based electronic devices: this is a key technological issue that is becoming dominant as we race toward the nanoscale. Second, toward identifying new optimal thermoelectric materials, which are of great relevance to energy conversion or cooling applications. To this end, I will perform a systematic study of the thermoelectric properties of promising materials, starting from ternary and filled CoSb3-based skutterudites. Third, toward characterizing structural and spectroscopic properties of materials and devices. Here I will place particular effort in building a database of thermo-mechanical and spectroscopic properties of the materials that show the most promising transport characteristics.",First-principles engineering of thermal and electrical transport at the nanoscale,FP7,30 November 2015,01 April 2012,91666.0 COOL-COVERINGS,Keraben Grupo,construction,"Recent work has shown the possibility to drastically increase the reflection performance of the building envelop, using nanotechnologies. Standard metal oxides are already known for their solar reflection properties, but latest developments identified that nanotechnologies can improve Index of Reflectance from an average of 0,35 to 0,85 because of their effectiveness on Near Infrared wavelengths, even on non white surfaces.",Development of a novel and cost-effective range of nanotech improved coatings to substantially improve NIR (Near Infrared Reflective) properties of the building envelope,FP7,05 July 2015,06 January 2010,0.0 COORDSPACE,University of Nottingham,energy,"The Applicant has an outstanding record of achievement and an international reputation for independent research across many areas of metal coordination chemistry. This high-impact and challenging Proposal brings together innovative ideas in coordination chemistry within a single inter- and multi-disciplinary project to open up new horizons across molecular and biological sciences, materials science and energy research. The Proposal applies coordination chemistry to the key issues of climate change, environmental and chemical sustainability, the Hydrogen Economy, carbon capture and fuel cell technologies, and atom-efficient metal extraction and clean-up. The vision is to bring together complementary areas and new applications of metal coordination chemistry and ligand design within an overarching and fundamental research program addressing: i. nanoscale functionalized framework polymers for the storage and activation of H2, CO2, CO, O2, N2, methane and volatile organic compounds; ii. new catalysts for the reversible oxidation and photochemical production of H2; iii) clean and selective recovery of precious metals (Pt, Pd, Rh, Ir, Hf, Zr) from process streams and ores. These research themes will be consolidated within a single cross-disciplinary and ambitious program focusing on the control of chemistry, reactivity and interactions within self-assembled confined and multi-functionalized space generated by designer porous framework materials. An AdG will afford the impetus and freedom via consolidated funding to undertake fundamental, speculative research with multiple potential big-hits across a wide range of disciplines. Via an extensive network of international academic and industrial collaborations, the Applicant will deliver major research breakthroughs in these vital areas, and train scientists for the future of Europe in an exciting, stimulating and curiosity-driven environment.","Chemistry of Coordination Space: Extraction, Storage, Activation and Catalysis",FP7,30 November 2013,01 December 2008,2492371.0 COPET,National Hellenic Research Foundation * Ethniko Idryma Erevnon,photonics,"The proposed research project aims at advancing a combined approach of quantum dynamics methodology and quantum control techniques applicable on photo-induced energy transfer processes on nanostructures consisting of carbon nanohorns, or CNHs, and molecular compounds with several stable equilibrium configurations, or MCCs. The ultimate objective of such studies is the design and development of nanoscale devices, such as plastic electronics, solar energy conversion cells, and artificial photosynthetic molecular complexes. For this purpose, we propose to combine the time dependent density functional theory with the Natural Transition Orbitals representation in order to study the electronic transition density which governs the photo-induced energy transfer process between electronic excited states in functionalized carbon nanostructures. The excitonic dynamics will be further investigated with quantum dynamical methods which take into account the coherent excitonic time evolution in interaction with the vibrational degrees of freedom in such systems. The manipulation of the photo-induced transfer process will be achieved by switching on demand between the different equilibrium configurations of the molecular compounds, which often have different physical properties, used for functionalization of the carbon nanohorns, by taylored laser pulses. Alternatively, the control of the photo-induced transfer process will be achieved by the introduction of metallic nanoparticles in the proximity of the functionalized carbon nanostructures and the resulting near-field effects on the electromagnetic density of states due to the scattered light. The scientific innovation expected, following the successful implementation of the present project, may reveal future technologies based on advanced functional nanoarchitectrures consisting of CNHs and MCCs in the areas of opto-electronics, solar energy conversion cells, and artificial photosynthetic systems.",Control of photo-induced energy transfer in functionalized carbon nanostructures towards design of nanoscale applications,FP7,30 September 2012,01 October 2008,100000.0 CORALWARM,University of Bologna * Alma Mater Studiorum Università di Bologna,environment,"CoralWarm will generate for the first time projections of temperate and subtropical coral survival by integrating sublethal temperature increase effects on metabolic and skeletal processes in Mediterranean and Red Sea key species. CoralWarm unique approach is from the nano- to the macro-scale, correlating molecular events to environmental processes. This will show new pathways to future investigations on cellular mechanisms linking environmental factors to final phenotype, potentially improving prediction powers and paleoclimatological interpretation. Biological and chemical expertise will merge, producing new interdisciplinary approaches for ecophysiology and biomineralization. Field transplantations will be combined with controlled experiments under IPCC scenarios. Corals will be grown in aquaria, exposing the Mediterranean species native to cooler waters to higher temperatures, and the Red Sea ones to gradually increasing above ambient warming seawater. Virtually all state-of-the-art methods will be used, by uniquely combining the investigators expertise. Expected results include responses of algal symbionts photosynthesis, host, symbiont and holobiont respiration, biomineralization rates and patterns, including colony architecture, and reproduction to temperature and pH gradients and combinations. Integration of molecular aspects of potential replacement of symbiont clades, changes in skeletal crystallography, with biochemical and physiological aspects of temperature response, will lead to a novel mechanistic model predicting changes in coral ecology and survival prospect. High-temperature tolerant clades and species will be revealed, allowing future bioremediation actions and establishment of coral refuges, saving corals and coral reefs for future generations.",Corals and global warming: The Mediterranean versus the Red Sea,FP7,05 July 2018,06 January 2010,3332032.0 CORESHELL,University Medicine of the Johannes Gutenberg-University Mainz * Universitätsmedizin der Johannes Gutenberg-Universität Mainz,health,"Core-shell materials are of enormous interest for many applications in nanotechnology and nanomedicine. Only recently, due to the achievements of the consortium, the generation of such nanoparticles by applying unique proteins from marine organisms has become possible. In this IAPP, based on a long-term and very successful cooperation between groups in Germany and Croatia, well known in the field of marine biotechnology of sponges and associated microorganisms, and now extended by an SME (NanotecMARIN GmbH) with a special focus on the exploitation of marine metal-oxide forming enzymes / proteins, a marine bacterial multicopper oxidase (MCO) and a sponge laccase, which are able to catalyze the oxidation of Mn(II) to Mn(IV), will be used to generate novel metal oxide nanocomposite materials. Enzymatically active MCO will be immobilized on magnetic iron oxide nanoparticles to enzymatically fabricate core-shell materials. In addition, MCO and laccase will be applied in combination with silica or other metal oxide-forming proteins (recombinant silicatein and silintaphin-1) to generate nanoparticles containing multiple shells of various materials, which can be doped with fluorescent dyes and proteins during their formation at mild conditions. These core-shell nanoparticles will be used in drug delivery, for removal of manganese or other heavy metals from contaminated aqueous solutions (remediation of contaminated environments), as well as for the development of antifouling strategies.",Marine nanobiotechnology: Manganese oxide-containing core-shell materials formed by proteins from marine organisms for biomedical and environmental applications,FP7,30 September 2015,01 October 2011,856022.0 CORNEA ENGINEERING,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The goal of the proposed research project is to reconstruct a human cornea in vitro, for use both in corneal grafting and as an alternative to animal models for cosmeto-pharmacotoxicity testing. The project responds to the urgent need to develop new forms of corneal replacements as alternatives to the use of donor corneas, in view of of the world-wide shortage of donors, the increasing risk of transmissable diseases, the widespread use of corrective surgery which renders corneas unsuitable for grafting, and the severe limitations of currently available synthetic polymer-based artificial corneas (keratoprostheses). The originality of the proposal lies in the use of recombinant human extracellular matrix proteins to build a nano-engineered scaffold to support growth of the different cell types found in the cornea, cells to be derived from human adult stem cell pools. The development of a reconstructed human cornea will represent a real breakthrough, allowing diseased or damaged corneas to be replaced by tissue-engineered human corneal equivalents that resemble in all respects their natural counterparts. The proposal also responds to impending ED legislation banning the marketing of cosmetic products that have been tested on animals, using procedures such as the Draize rabbit eye irritation test. The development of tissue engineered corneas will provide a non-animal alternative which will therefore alleviate animal suffering. The project will lead to a transformation of industry to meet societal needs using innovative, knowledge-based approaches integrating nanotechnology and biotechnology. The project brings together 14 participants with complementary expertise from 9 different countries, including basic scientists, ophthalmologists and industrialists (three SMEs). Ethical and standardisation aspects will also be included.",THREE-DIMENSIONAL RECONSTRUCTION OF HUMAN CORNEAS BY TISSUE ENGINEERING,FP6,31 December 2007,01 January 2004,2558797.0 CORRAL,University of Applied Sciences Western Switzerland * Haute École Spécialisée de Suisse Occidentale,transport,"The aim of this project is to develop high density defect-free ultra-thin sealing coatings with excellent barrier properties and improved corrosion resistance. Their successful functioning will be provided by the synergy of the coating “perfect†morphology and its complex structural design, which can be tailored at the nanoscale. The study will be focused on development of novel nanostructured coating systems, such as nanoscale multilayers, mixed and composite coatings. These impermeable sealing layers must be able to block the ion exchange between the substrate material and an aggressive environment, thus offering an efficient protection against corrosion over a long term. The coatings will be deposited by four alternative vapour deposition techniques, Filtered Cathodic Arc Deposition (FCAD), High Power Impulse Magnetron Sputtering (HIPIMS), Atomic Layer Deposition (ALD) and Plasma Enhanced Atomic layer Deposition (PEALD)). These techniques possess a unique advantage offering the deposition of highly conformal and uniform films of high density, free of defects. The technological objective of the project is to demonstrate the feasibility of corrosion protection by FCAD, HIPIMS and ALD techniques on an industrial scale. To fulfil this objective, a complete industrial process for the multi-stage surface treatment, including cleaning, pre-treatment, coating deposition, must be defined. All techniques will be evaluated in terms of technical effectiveness, production costs, environmental impact and safety, and the most suitable technique(s) will be selected for further development on a large scale for the applications in some targeted industrial sectors. The applications, tested within this project, concern high precision mechanical parts (bearings), aerospace components (break systems) and gas handling components. The coating application in the decorative and biomedical domains will be assessed.",Corrosion protection with perfect atomic layers,FP7,08 July 2013,09 January 2008,3376606.0 COSMOPHOS-NANO,University of Eastern Finland * Itä-Suomen Yliopisto,health,"CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives: 1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up therapy monitoring of atherosclerotic coronary artery disease (CAD), 2) nonclinically evaluate this system, 3) clinically validate the system after regulatory approval, & 4) reduce in the long-term CAD deaths and morbidity by up to 40%, resulting in a significant decrease of the European and global healthcare costs for CAD, increasing the income of the European healthcare industry from CAD market which is the global largest. The CosmoPHOS-nano consortium has a five year history of successful collaboration between the industrial and academic partners, and its funding would underpin a team devoted to delivering a novel powerful & affordable healthcare solution against the leading cause of death, without the need for heavy and expensive medical equipment. The CosmoPHOS system consists of two interacting components: a) targeted theranostic near-infrared photoactivatable biocompatible nanomedicines, and b) medical devices. After systemic administration, the nanomedicines targeted accumulate in coronary atherosclerotic plaques, followed by endocoronary photoactivation and detection by the medical devices, enabling molecular imaging, targeted therapy, real-time & follow-up therapy monitoring of CAD. Preliminary in vitro & in vivo successful experimental results, as well as parts of the CosmoPHOS system are already available from the prior five year collaboration. The project plan includes: A) nonclinical R&D (30 months); B) nonclinical validation & regulatory approval (18 months); C) first-in-man phase-I clinical trial in 20 CAD patients (12 months).",Novel nanotechnology-enabled system for endovascular in vivo near-infrared fluorescence molecular imaging and endovascular near-infrared targeted photodynamic therapy of atherosclerotic heart disease,FP7,28 February 2018,01 March 2013,8503352.0 COSPINNANO,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,health,"The rapid development of novel nanoelectronic devices utilizing the spin degree of freedom of the charge carriers and thus reaching beyond the limitations of traditional semiconductor based technologies is one of the central issues in nowadays spintronics. A special emphasis is put on the fabrication and investigation of hybrid nanostructures exploiting the complementary benefits of metallic, semiconducting, magnetic as well as the recently explored, low dimensional carbon based systems (carbon nanotubes, graphen). The proposed project aims to design various hybrid nanostructures defined by optical and electron beam lithography and to develop novel schemes for determining spin-related material parameters (g-factor, spin diffusion length, spin-injection efficiency and spin transfer torque) via transport measurements. This is essential in order to explore electron spin dynamics, decoherence and relaxation for multifunctional applications (fast switching elements, combined logical and storage devices, quantum dot based semiconductor spin qbits) and to determine conditions for coherent spin-transfer in nano/micro-circuits as well as methods of detection of spin currents. These experiments help to understand and control the coherent spin states of individual charge carriers, which is fundamental for the field of quantum computation in a solid state environment. The host institute possesses all the necessary nanofabrication facilities and the high-end cryogenic background for the successful implementation of device fabrication and low-level magnetotransport measurements. The host has also pioneered the measurement technique for determining spin-polarization and spin transfer torque in nanoscale magnetic systems with a resolution down to the scale of atomic junctions.",Coherent spin manipulation in hybrid nanostructures,FP7,31 August 2015,01 September 2011,100000.0 COSPSENA,University of Basel * Universität Basel,information and communications technology,"Macroscopic control of quantum states is a major theme in much of modern physics because quantum coherence enables study of fundamental physics and has promising applications for quantum information processing. The potential significance of quantum computing is recognized well beyond the physics community. For electron spins in GaAs quantum dots, it has become clear that decoherence caused by interactions with the nuclear spins is a major challenge. We propose to investigate and reduce hyperfine induced decoherence with two complementary approaches: nuclear spin state narrowing and nuclear spin polarization. We propose a new projective state narrowing technique: a large, Coulomb blockaded dot measures the qubit nuclear ensemble, resulting in enhanced spin coherence times. Further, mediated by an interacting 2D electron gas via hyperfine interaction, a low temperature nuclear ferromagnetic spin state was predicted, which we propose to investigate using a quantum point contact as a nuclear polarization detector. Estimates indicate that the nuclear ferromagnetic transition occurs in the sub-Millikelvin range, well below already hard to reach temperatures around 10 mK. However, the exciting combination of interacting electron and nuclear spin physics as well as applications in spin qubits give ample incentive to strive for sub-Millikelvin temperatures in nanostructures. We propose to build a novel type of nuclear demagnetization refrigerator aiming to reach electron temperatures of 0.1 mK in semiconductor nanostructures. This interdisciplinary project combines Microkelvin and nanophysics, going well beyond the status quo. It is a challenging project that could be the beginning of a new era of coherent spin physics with unprecedented quantum control. This project requires a several year commitment and a team of two graduate students plus one postdoctoral fellow.",Coherence of Spins in Semiconductor Nanostructures,FP7,05 July 2015,06 January 2008,1377000.0 COST-EFFECTIVE,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,energy,"The use of renewable energy in the building sector is today dominated by the application of solar domestic hot water and PV systems in single-family houses. In order to significantly increase the use of renewable energy in the building sector, concepts have to be developed for large buildings. In these buildings high fractions of the energy demand can only be met with renewable energy sources, when the façade is used for energy conversion in addition to the roof. This is especially true for buildings with a small roof area compared to the floor area ('high-rise buildings') and for existing buildings which generally have a higher energy demand than new buildings. Therefore the main focus of the project is to convert facades of existing 'high-rise buildings' into multifunctional, energy gaining components. This goal will be achieved through the - development of new multi-functional façade components which combine standard features and the use of renewable energy resources and the - development of new business and cost models which consider the whole life cycle of a building and which incorporate the benefits from reduced running costs and greenhouse-gas emissions. The new components will in particular profit from the application of nano-structured coatings and films which will enhance their performance and durability due to antireflective, anti-soiling and seasonal shading functionality. In order to achieve a successful development and implementation of these new technologies and concepts European key actors from construction industry and energy research have agreed to collaborate within this project. The project results will be an important support for the European technology platforms ECTP, ESTTP and PV-platform in which the project partners have a leading role.",Resource- and Cost-effective integration of renewables in existing high-rise buildings,FP7,30 September 2012,01 October 2008,7492346.0 COSUN,London School of Economics and Political Science,photonics,"Many of the remarkable properties of molecular nanostructures are cooperative effects. A system is described as cooperative when it behaves differently from expectations based on the properties of its individual components. Multivalent cooperativity is crucial for biological molecular recognition, yet the factors determining the magnitude of this effect are poorly understood. Excitonic cooperativity is exploited in sensitive detectors for explosives, and is the basis of photosynthetic light harvesting. Electronic cooperativity is illustrated on the molecular scale by the phenomenon of aromaticity, and on a larger scale by metallic conductivity. Magnetic properties provide many examples of cooperativity. The magnitude of cooperative effects increases with the strength of coupling between the individual components, and with the number of coupled components. Cooperative systems exhibit sharp changes in behavior in response to small changes in conditions, such as transitions from free to bound, fluorescent to non-fluorescent, or conductive to insulating. The tendency towards an 'all-or-nothing' response is often useful; in the limit of a very large ensemble, it leads to phase transitions. The CoSuN project will extend methodology developed in Oxford to create large monodisperse supramolecular nanostructures which are uniquely suited for exploring multivalent, excitonic and electronic cooperativity. The template-directed synthesis of these nanostructures is made possible by strong multivalent cooperativity, while the electronic coupling between the individual subunits results in other cooperative phenomena. This project will clarify understanding of cooperative molecular recognition. It will also help to solve some of the mysteries of photosynthesis and reveal the first molecular manifestations of coherent quantum mechanical phenomena, such as Aharonov-Bohm effects.",Cooperative Phenomena in Supramolecular Nanostructures,FP7,30 April 2018,01 May 2013,2452688.0 COSY,Centre for Materials and Coastal Research * Helmholtz-Zentrum Geesthacht – Zentrum für Material- und Küstenforschung GmbH,energy,"Reactive Hydride Composites reveal great potential as hydrogen storage materials as they overcome the thermodynamic limitations hindering the use of light-weight complex hydrides. However, their sorption kinetics is still slow due to the fact that the hydrogen sorption process takes place within complex solid state reactions. It is aim of this project to explore the fundamental mechanisms involved in these reactions. For this, experimental studies on sorption kinetics, thermodynamics, crystal structure and electronic properties of the nanostructured materials are crosslinked to ab-initio calculations and theoretical modelling. The results will provide a basis to improve material properties and to develop new catalysts for hydrogen sorption. Finally, the optimization of synthesis methods and in particular the upscaling of hydrogen storage materials preparation will be explored in collaboration with manufacturers.",Complex solid state reactions for energy efficient hydrogen storage,FP6,31 October 2010,01 November 2006,2467170.0 COTECH,Cardiff University,health,"The objective of the project COTECH is to investigate new approaches of µ-manufacturing based on advanced technology convergence processes and to propose hybrid solutions for high added value cost effective µ-manufacturing emerging applications. The main goals of COTECH are to develop: (1) µ-replication technologies underpinned by emerging tool-making technologies for processing multi-material components and creating: a) 3D µ-components using high throughput multi-material µ-injection moulding with sub-µm resolution; b) 2D µ-components using direct multi-material hot or UV embossing with a sub-200nm resolution. (2) Radically new replication convergent technologies combining the capabilities of µ-injection or embossing to a complementary activation step to create intelligent devices in a single process step: a) Hybrid processes based on µ-injection moulding using modules of e.g coating and compression injection moulding, to provide functionality to µ-devices, such as active coatings and combination of micro and nano features in a single step; b) Ultimately the hybrid processes based on µ-injection with embossing will be validated. This will offer a very high throughput multimaterial µ-injection that will enable the fabrication of 3D high aspect ratio µ-parts, complemented by an embossing step to allow ultra precise 2D features. (3) Global process chains with increased MTBF (50%) and fabrication of high quality products. This requires innovative non-destructive inspection solutions and simulation models. (4) High added value µ-devices with advanced functionalities. COTECH proposes to validate industrially the new technology convergence processes with 8 demonstrators representing the most emergent industrial sectors (transport, biomedical, energy). The expected market for the industry exceeds 1 Billion €. COTECH will also address the problem of knowledge fragmentation by activating a polymer µ-manufacturing sub-platform as support to MINAM.",Converging technologies for micro systems manufacturing,FP7,31 October 2012,01 October 2008,6000000.0 COUNTATOMS,University of Antwerp * Universiteit Antwerpen,information and communications technology,"COUNTING ATOMS IN NANOMATERIALS Advanced electron microscopy for solid state materials has evolved from a qualitative imaging setup to a quantitative scientific technique. This will allow us not only to probe and better understand the fundamental behaviour of (nano) materials at an atomic level but also to guide technology towards new horizons. The installation in 2009 of a new and unique electron microscope with a real space resolution of 50 pm and an energy resolution of 100 meV will make it possible to perform unique experiments. We believe that the position of atoms at an interface or at a surface can be determined with a precision of 1 pm; this precision is essential as input for modelling the materials properties. It will be first applied to explain the fascinating behaviour of multilayer ceramic materials. The new experimental limits will also allow us to literally count the number of atoms within an atomic columns; particularly counting the number of foreign atoms. This will not only require experimental skills, but also theoretical support. A real challenge is probing the magnetic and electronic information of a single atom column. According to theory this would be possible using ultra high resolution. This new probing technique will be of extreme importance for e.g. spintronics. Modern (nano) technology more and more requires information in 3 dimensions (3D), rather than in 2D. This is possible through electron tomography; this technique will be optimised in order to obtain sub nanometer precision. A final challenge is the study of the interface between soft matter (bio- or organic materials) and hard matter. This was hitherto impossible because of the radiation damage of the electron beam. With the possibility to lower the voltage to 80 kV and possibly 50 kV, maintaining more or less the resolution, we will hopefully be able to probe the active sites for catalysis.",Counting Atoms in nanomaterials,FP7,12 July 2016,01 January 2010,2000160.0 COVAQIAL,Free University of Brussels * Université Libre de Bruxelles,information and communications technology,"In the recent years, quantum continuous variables (QCV) have emerged as a tool of major importance for developing novel quantum communication and information processing protocols. Encoding quantum continuous information into the quadrature of a quantized light mode or into the collective spin variable of a mesoscopic atomic ensemble has proven to be a very interesting alternative to the standard concept of quantum bit-based processes. Several experimental breakthroughs have been achieved recently demonstrating this concept, namely the quantum teleportation of a coherent state, the generation of entangled light beams with soliton pulses in nonlinear fibers, the preparation of distant entangled atomic ensembles, or the implementation of a quantum key distribution scheme relying on coherent states. In view of these spectacular results, many developments of QCV information systems can be foreseen.The present proposal aims at initiating an exploratory research on new quantum informational concepts involving continuous variables, both on the theoretical and experimental sides. It departs from the 'traditional' approaches of quantum computing in that we do not address the 'scalability' of some potential technology for quantum information processing which is not yet applicable. Instead, we start from a concept that has already been proven very successful in the laboratory. The topics which we plan to cover include improved or novel quantum communication protocols, quantum memories and quantum repeaters based on the light-atoms quantum interface, and the generation of squeezed or entangled solitonic light beams based on various nonlinearities in fibers. The role of non-Gaussian states of light will also be investigated in order to make new QCV informational processes possible. Another focus of this project will be the study of the fundamental physics governing the off-resonant interaction of light with an atomic ensemble.",COntinuous VAriable Quantum Information with Atoms and Light,FP6,31 August 2007,31 August 2004,1400000.0 CP-SMARTSURFACES,Dublin City University,health,"Discovered just over 20 years ago, conducting polymers (CPs) have gained considerable attention because of their unique chemical and electronic conducting properties. As a result they have various (bio)analytical and technological applications. CPs are easily synthesised, both chemically and electrochemically under mild conditions, opening up vast possibilities for the immobilisation of biomolecules. Immobilisation of antibodies by entrapment within films or by covalent binding on these films permits the straightforward fabrication of biosensors. In electrochemical biosensors, non-specific binding (NSB) of molecules, e.g. proteins in serum, can occur, lowering overall device performance. In the past, surface chemistry has been employed to prohibit NSB on electrodes with sites that do not have antibodies attached. This surface chemistry however, impairs device performance. CPs have inherent dynamic surface properties that can be easily switched upon the application of an appropriate electrical potential. Their ability to be switched between different oxidation states and the associated switch in properties such as doping level, resistance and surface wettability can be controlled by changing the electrical potential resulting in reversible switching. Routes to nano-dimensional CPs, exhibiting markedly improved properties from those of the bulk materials, have been recently developed. We therefore propose to exploit the dynamic chemical nature of CPs to inhibit NSB in electrochemical bio-assays and demonstrate the efficacy of this approach using a simple nanostructured electrochemical prostate cancer diagnostic platform made from conducting polymers. One can imagine the significance of a biosensor that provides increases in performance and shorter detection times, since the immobilising platform, transducer and dynamic surface control are implemented within a single material.",Towards better point of care devices: Conducting polymers as smart surfaces in biosensors.,FP7,06 July 2015,01 May 2008,100000.0 CPSULPVLSI,University of Alberta,information and communications technology,"Applications for ultra low-power wireless technologies are in strong demand today and their significance will continuously increase in the nearest future. Modern medical, telecommunication and multimedia applications are among the main research fields for wireless systems designers. New solutions are requested at the conceptual, circuit, and hardware levels. The aim of this research project is to develop and design new classes of low-power circuits optimised for modern CMOS technologies typically ranging from 0.18um, down to 65nm. In cooperation with Host Institutions, the applicant will investigate various novel circuit and device solutions for modern Systems-On-Chip, like e.g. quasi-floating gate circuits, where MOSFET gates are connected through very large impedance to the power supply and operate below 1V, new CMOS circuits that operate based on transistor sub-threshold or moderate inversion operation, new devices structures that would enable low-power operation such as linear MOS varactors, that help improving phase noise properties of LC oscillators, tunneling FETs (TFETs), and provide more efficient driving capabilities than MOSFETs operating in sub-threshold. One of the applicant’s research objectives is development of new classes of embedded analog filters for ultra low-power applications working below 1 mW. Such filters need quite new architectures and design of ultra low-power active elements. Research solutions will be examined by designing and testing four VLSI Application Specific Integrated Circuits (ASICs), which are accessible in Canada and in Europe. Work in good research teams in Host Institutions will enable the applicant to reach high scientific and personal development. The experience obtained during fellowship will be used in development of the VLSI research group at Poznan University of Technology. One of the objectives of OIF is long term international cooperation with Host Institutions, knowledge transfer, and modern industry applica",Development of Novel Classes of High Performance Microelectronic Systems on Chip for Ultra Low Power Wireless Applications,FP6,31 August 2009,01 September 2006,224298.84 CQ3D,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"cQ3D proposes a 48-month program to improve the quantum coherence of superconducting flux qubits using cutting-edge developments in circuit quantum electrodynamics (QED). Beyond the immediate benefit to quantum computing with superconducting circuits, this effort will enable fundamental physics, such as the investigation of non-equilibrium quasiparticles in superconductors. Finally, it will pave the way for hybrid quantum computing with superconducting flux qubits coupled to electronic spins.",3D Circuit Quantum Electrodynamincs with Flux Qubits,FP7,01 July 2018,02 January 2012,0.0 CRBEC,University of Stuttgart * Universität Stuttgart,information and communications technology,"A Bose-Einstein Condensate (BEC) in chromium (Cr) has been created recently. Compared to other species, Cr has two assets: it can be used for lithography, and, due to its large magnetic moment, the long-range, anisotropic magnetic dipole-dipole interaction (MDDI) is comparable to the contact interaction usually at work in standard BECs. MDDI is of general interest as it provides the cold atoms community with a new tool in the interdisciplinary field of quantum engineering. MDDI is intermediate between the contact interaction encountered in atomic physics, and the Coulomb interaction present in condensed-matter systems. MDDI provides a way to study, in a clean model system with tuneable parameters, fundamental problems arising in solid-state physics, such as quantum magnetism or spintronics. In this project, we plan to study experimentally the new BEC properties arising from the MDDI. A Cr condensate is the only system so far in which such phenomena can be observed. We will first study the dependence of the condensate stability on the trap geometry. Then, the excitations of the condensate will be studied: we will measure the excitation spectrum, in which a roton minimum (similar to the one in liquid He) has been predicted. For such studies, tuning short and long-range interactions (with Feshbach resonances and rotating magnetic fields, respectively) is crucial. In a second step, we plan to engineer new, highly correlated quantum states of matter, by loading the Cr BEC into an optical lattice. The interplay between contact interaction, MDDI, and tunnelling induces a wealth of unexplored quantum phases, such as supersolid or `checkerboard ones. The project lies in a highly competitive research field, at the border between atomic and condensed-matter physics, and will therefore contribute to the excellence of European research. It will also highly improve to my professional maturity by allowing me to broaden my experimental and theoretical skills.",Studies of magnetic dipole-dipole interactions in a Chromium Bose-Einstein Condensate,FP6,30 November 2008,01 December 2006,157064.0 CRITICALFORCE,Bilkent University * Bilkent Üniversitesi,information and communications technology,"Nanoscience and nanotechnology are in the process of revolutionising the way we live and do science. In the context of this drive towards the nanoscale, the specific aim of the present project to provide new tools to harness forces and interactions at mesoscopic and nanoscopic length-scales, e.g., the forces arising between several nanodevices, by gaining a better understanding and by exploring possible applications of critical Casimir forces. Critical Casimir forces are interesting from the fundamental point of view as a manifestation of critical phenomena, but also, and perhaps more importantly, from the technological point of view, e.g., as a tunable mechanism to prevent the sticking in MEMS and NEMS (micro- and nanoelectromechanical systems) due to QED (quantum-electrodynamical) Casimir forces. The experimental study of critical Casimir forces acting on microscopic object is a fairly new field of research, which can benefit from the novel techniques we are going to deploy within this proposal.",Applications of Critical Casimir Forces,FP7,07 July 2018,08 January 2012,100000.0 CRONOS,Trinity College Dublin,energy,"The CRONOS project seeks to develop a quantitative, flexible and fully atomistic theory of ultrafast dynamics in real materials. Our effort will create the necessary knowledge for advancing two technological areas crucial for the economic future of Europe and the well being of its citizens: new materials for solar energy harvesting and ultra-high density magnetic data storage. In particular we will construct the necessary theoretical tools for addressing the problems of energy photo-conversion and laser-induced ultrafast magnetization dynamics. Crucially CRONOS will not just look at how an optical excitation perturbs a materials system but also at how such an excitation can be engineered to produce a desired response. Hence both the direct and the inverse problem will be tackled. CRONOS' theoretical program will be validated by a broad experimental activity on ultra-fast pump-probe spectroscopy and by the presence in the consortium of European companies. Equally important is the fact that the consortium will produce a substantial amount of high-end scientific software, which will then be distributed freely to the academic community. The project will develop a quantitative and materials-specific theory for electron dynamics in nano-structures, which, at the same time, is fully atomistic, efficient, scalable to large systems, and rigorously theoretically formulated. The core of our method is time-dependent density functional theory, TDDFT, which was invented by a member of our consortium and has been developed over the years . Our workplan comprises formal methodological development, algorithm implementation, applications to both solar cells and magnetic recording, and experimental validation. A significant deliverable of this project will also be the wide distribution of computational packages",Time dynamics and ContROl in naNOStructures for magnetic recording and energy applications,FP7,31 May 2015,01 June 2012,3380058.0 CROSS-SERS,Rovira i Virgili University * Universitat Rovira i Virgili,health,"The goal of the present project is the development of novel nanostructured cross-sensor reactive arrays (CRSA) based on SERS and the different affinity of peptides and proteins to interact with different metallorganic complexes. This sensor concept will be universal for the ultrasensitive detection and identification of metallic cations and peptides/proteins. Briefly, we shall fabricate micron-sized, composite nanomaterials as follows. Gold nanoparticles will be first deposited on silica or polymer microspheres via layer by layer self-assembly, and subsequent epitaxial growth will be carried out with silver (using novel methods recently developed in our lab) to generate discrete, highly SERS active surfaces. These composite particles will be functionalized with organic ligands with high affinity for metals (thiolated porphyrins and terpyridines). In a first step, quantitative multiplex ultrasensitive detection of metals will be aimed. In a second step, each microsphere coupled with one ligand and a given metal will be fabricated as a sensing element for the CRSA. These sensing elements will be organized into solid supports (the actual CRSA) and tested for the identification of different protein species, especially those related with pathogenic states or drug abuse, by combining SERS spectroscopy with chemometric methods (i.e. principal component analysis, hierarchical cluster analysis and partial least squares). The final product is intended to be mounted on a conventional glass slide with ability for drawing a rapid and accurate conclusion on the health condition of a patient, or environmental risk in a time scale of seconds.",SERS ultrasensitive universal sensing of proteins through cross-reactive sensor arrays,FP7,30 April 2015,01 May 2013,166336.0 CROSSTALK IN GBMS,University of Verona * Università degli Studi di Verona,health,"The applicant is an experienced researcher with the objective of completing comprehensive training in translational research on Glioblastoma Multiforme (GBM), one of the most common malignant and lethal primary brain tumor of adults, with the final aim of disposing of personalized therapeutic protocols for GBM and cancer patients. The project is based on the finding that human tumors, particularly GBMs, are composed of a mixture of cancer, immune, stromal and vascular cells. The non-cancerous cellular components of the tumor microenvironment appear to play a critical role in tumor development and progression. At UCLA (Los Angeles, U.S.A.), the Mischel Lab has developed the DNA Encoded Antibody Library (DEAL) microarray, to sort specific cellular subtypes from solid tumor samples. The selective capture of tumor cells, lymphocytes, microglia and vascular endothelial cells, directly from GBM biopsy samples, will be obtained by DEAL technology. Genomic and transcriptional analysis will be performed on DEAL sorted cellular subtypes in order to identify novel molecular targets for therapeutic intervention. Genomic and transcriptional findings will be validated with functional assays in model systems: oncogene overexpression, gene silencing and pharmacological inhibition will be applied in order to identify the factors that inhibit the growth and survival of GBMs. In the first phase of the fellowship, at UCLA, the applicant will be utilizing cutting edge nanotechnology and resources that will provide her with outstanding interdisciplinary skills and competences. The applicant will then have the professional maturity to transfer her novel knowledge to the University of Verona (Italy), enriching the scientific excellence of Europe and bridging a new set of collaborations between Italy and the U.S.A.",GENOMIC AND TRANSCRIPTIONAL ANALYSIS OF GLIOBLASTOMA MICROENVIRONMENTAL CELLULAR SUBSETS USING ANTIBODY MICROARRAYS,FP7,30 September 2014,01 October 2011,230084.0 CRYOCOURSE,Helsinki University of Technology * Teknillinen Korkeakoulu,transport,"The demand of training in cryogenics for researchers and students has steadily increased following the development of research at low temperatures in physics and technology (nanoscience, nanotechnology, material sciences, low noise electronics, detectors for astrophysics, cryogenic propulsion for rockets, superconducting magnets for accelerators in particle physics and large scale fusion research, etc.). The objective of the Course is to provide European young researchers from laboratories, large scale facilities or industry, with practical training at the doctoral and post-doctoral level in the field of Cryogenics. This will be achieved by lectures and practical courses given by teachers belonging to prestigious European research centres and leading cryogenics enterprises. Training several hundreds of young researchers in advanced cryogenics requires adequate facilities and skilled technical staff only available in a few large low temperature laboratories in the world. In Europe, Grenoble and Helsinki are internationally leading institutions is this field, with a long tradition in training in Cryogenics. Two training courses are foreseen (Grenoble and Helsinki), as well as two conferences, organised in two other European countries. This course will contribute to develop the competitiveness of European research and industry by providing valuable training, disseminating scientific and technological knowledge, favouring the links between academic and industrial research, and creating strong professional links between event participants from different countries. This activity will also enable researchers of countries where knowledge in cryogenics is not developed to bridge a technological gap. The participation of women, underrepresented in our field, will be encouraged. The positive effect of these courses is demonstrated by our experience of cryogenics training at the level of undergraduates (Socrates CEE Programme).",Marie Curie Advanced Cryogenics Course,FP6,31 December 2010,01 January 2007,287350.81 CRYOMAS4DNP,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"We intend to develop a new nano-characterization technique able to complement the tools currently available (AFM, TEM, XPS etc.) and to palliate the inadequacies and/or sensitivity limitations of atomic resolution techniques such as X-ray diffraction and solution NMR. Indeed, despite their success to resolve structures, they do not contribute as much to the tremendous ongoing advances in nanoscience: i.e. development of molecular memories, molecular electronics, nano-biosensors, etc. The reason relies mainly in the intrinsic nature of the samples involved (either non-crystalline or insoluble materials) and the subsequent poor detection sensitivity associated. The objective of the project is to develop a particular form of solid-state Nuclear Magnetic Resonance able to enhance the nuclear spin sensitivity by 4 to 6 orders of magnitude. To achieve this objective, we will use a high power microwave source to irradiate the unpaired electron spins (contained in optimized polarizing agents) in order to hyperpolarize surrounding nuclear spins through a mechanism called Dynamic Nuclear Polarization (DNP). The experiments will be conducted at high magnetic field, with a temperature ranging from 10 to 300 K and rotation of the sample at the magic angle in order to retain high resolution NMR conditions. The project also intends to demonstrate the pertinence of the approach for atomic structure determination of challenging nano-systems beyond reach by other techniques, e.g. functionalized nanotubes/molecular wires, paramagnetic systems (porphyrins, proteins, etc.) as well as very large non-crystalline and insoluble biomolecular systems.",Cryogenic Magic Angle Spinning For Nuclear Dynamic Polarization,FP7,12 July 2015,01 January 2010,100000.0 CRYOTRANSLATION,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,environment,"Translation of the genetically encoded information into polypeptides, protein biosynthesis, is a central function executed by ribosomes in all cells. In the case of membrane protein synthesis, integration into the membrane usually occurs co-translationally and requires a ribosome-associated translocon (SecYEG/Sec61). This highly coordinated process is poorly understood, since high-resolution structural information is lacking. Although single particle cryo-electron microscopy (cryo-EM) has given invaluable structural insights for such dynamic ribosomal complexes, the resolution is so far limited to 5-10 Å for asymmetrical particles. Thus, the mechanistic depth and reliability of interpretation has accordingly been limited.",High Resolution cryo-EM Analysis of Ribosome-associated Functions,FP7,04 June 2019,05 January 2012,0.0 CRYSURFSIM,University of Cambridge,health,"Crystals exhibit various external morphologies ranging from the dendritic forms of snow crystals, the needle shape of epsom salt or the cubic form of rock salt. Understanding, simulating and influencing the crystal morphology is a major concern in today´s crystal morphology engineering. A widespread problem in industry is the appearance of undesired crystal morphologies giving rise to problems in handling and product-quality, or to such issues concerning the blinding of filters and tubes. Moreover, the design of crystal morphologies has gained an increasing interest within 'for example' the pharmaceutical industry or the application of nanotechnology, because influencing the crystal morphology enables the crystal engineer to prepare materials with tailored physical and chemical properties. The morphology of crystals is determined by many parameters, such as crystal structure, surface energy, supersaturation, temperature, pressure and the uptake of impurities. According to this, several methods exist to predict crystal morphologies favouring one of the driving parameters over the other. The aim of the proposed project CRYSURFSIM (crystal surface simulations) is to develop a unified crystal growth model that combines classical crystal growth theories with modern quantum mechanical simulations. Thus the bond valence deficiency model (BVD) developed by the applicant (Mutter, 2007), merging the geometrical crystal growth theories based on Bravais-Friedel-Donnay-Harker together with the bond valence approach of Brown (2002), will be extended by application of the Density Functional Theory (DFT), Molecular Dynamic Simulations (MDS), Lattice Dynamic Simulations (LDS) and Monte Carlo Simulations (MCS). This innovative approach to balance different crystal growth models with atomistic simulations will lead towards a harmonized model, by which crystal surface processes and crystal morphologies can be simulated satisfactorily.",Crystal surface simulations,FP7,02 January 2014,03 January 2012,209092.0 CSKFINGERPRINTS,Queen Mary University of London,health,"The main goal of this proposal is to induce and detect in real time and at single-cell level the differentiation of human mesenchymal stem cells using mechanical loads in 2D and 3D conditions. This proposal integrates disciplines from nanotechnology, bioengineering and cell and molecular biology. First we propose to develop a method to track the differentiation of stem cells in real time and at the single cell level using cytoskeletal organization of actin, microtubules and intermediate filaments as a suitable cell biomarker. We will then establish mechanical loading protocols to induce, via direct force application onto cells, the first stages of stem cell differentiation towards specific cell lineages. We will apply cyclic tensile strain and compression to stem cells in 2D and 3D conditions, and track their differentiation status in real time using the cytoskeletal biomarkers that we will have identified before. The results of this proposal will have implications for the field of stem cell mechanobiology in particular, and some of the techniques developed will also contribute to the wider field of directed stem cell differentiation.",Mechanical loading to direct stem cell differentiation,FP7,30 April 2018,01 May 2014,100000.0 CSRR,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),health,"Fluorescence imaging is a powerful technique that has transformed our understanding of biology. Recently, a number of techniques have been developed that overcome one of the fundamental limitations of fluorescence imaging, namely the diffraction limit. With these techniques, it is now possible to resolve sub-cellular architecture in multiple colors and 3D with unprecedented detail. However, the main limitation of these techniques has been the slow acquisition times making it difficult to study dynamic processes. Since biological samples are inherently highly dynamic, this limitation is a major hurdle that needs to be overcome. I will develop a correlative fluorescence imaging technique that combines the capabilities of super resolution and real-time imaging. With this correlative technique it will be possible to observe the dynamics of a biological sample in real-time and subsequently 'freeze' the dynamics (by fixation or low temperature) at a time of interest to obtain a super resolution image. The dynamics can therefore be correlated with ultrastructural information, combining the capabilities of real-time and super resolution imaging. I will apply this correlative imaging technique to study infection mechanism of Herpes Simplex Virus (HSV). HSV is a medically important virus that infects neurons and epithelial cells. Besides the health hazards that it poses, HSV also has important implications in gene therapy. However, the details of HSV infection mechanism remain poorly understood. Since HSV infection involves dynamic interactions between virus particles and sub-cellular components, both of which are tens of nanometers in length scale, this is an ideal model system in which the correlative super resolution and real-time imaging technique will lead to important insights that were previously unattainable.",Correlative Super Resolution and Real-Time Imaging of Herpes Virus Infection,FP7,28 February 2015,01 March 2011,100000.0 CTNFI,University of Warwick,information and communications technology,"The objective is to investigate charge transfer processes in three important nanoscale systems, using a range of novel measurement techniques, and to understand how charge transfer can be controlled and regulated by design at the nanoscale. Interfacial charge transfer is an essential aspect of nanoscale (molecular) electronics, and related fields, and there is currently much interest in organic, polymer and supramolecular systems as integral components in devices. Three important nanoscale systems will be investigated: 1) nanoparticle and conducting polymer/nanoparticle composite films; 2)supramolecular nanowires comprising redox-active metallo-cyclodextrin hosts and metalloguests with terpyridyl ligating units; 3) single-walled carbon nanotube (SWNT) devices. Highlights of the programme include: examining the effect of organisation on the conductivity of nanostructured thin films using a novel combination of scanning electrochemical microscopy (SECM) in a Langmuir trough; functionalising surfaces with molecular wires and measuring the relationship between the force of chemical interaction in the wire and conductivity, using conducting-atomic force microscopy (C-AFM); making electrochemical sensors from individual SWNTs and probing their local reactivity with combined SECM-AFM. The proposed investigations will provide a unique opportunity to examine the relative merits of different types of nanoscale system and to carry out several types of new measurements and experiments, which could have a major impact worldwide.The fellowship will provide an opportunity to collaborate and meet with some of the world and apos;s leading experts in interfacial nanoscale science, and to learn advanced skills in SECM, C-AFM and SWNTs, as well as extending and broadening my experience of methods for creating nanostructured interfaces. Such an opportunity would be extremely valuable for my ambition of gaining a full time academic post.",Charge Transfer at Nanofunctionalised Interfaces,FP6,31 August 2007,01 September 2005,160180.0 CUVITO,TWI Ltd.,health,"Antibacterial coatings represent a huge market in healthcare and food sectors.CuVito brings together Mexican mining products and European product development, to produce a state-of-the-art copper nano-structured coating. Bacteria in hospitals present a major health issue.The effectiveness of cleaning is considerably enhanced on smooth, scratch-free surfaces.Anti-bacterial silver coatings are available; however they are not used in hospitals due to cost, effectiveness and durability.Copper offers a low cost, effective and environmentally friendly solution that could be readily adopted. The challenge is to retain copper nano-particles in a structure that provides antibacterial functionality, but prevents leaching.The CuVito consortium believes that the silsesquioxane structure, formed using Vitolane technology is the answer. Silsesquioxanes have the formula RSiO1.5 (where R is an organic ligand), and form cage or ladder structures.They confer hardness and abrasion resistance to coatings and, by selecting appropriate R groups (e.g. acrylate, glycidoxy) can chemically bond to the organic resin in the formulation controlling cross-link density to enhance durability.Hence silsesquioxanes are inherently suited to use in coatings for surfaces which require regular cleaning.Silsesquioxanes have been available for some years but at a prohibitively high cost, due to the complexity of manufacture.Vitolane technology is an alternative, cost effective production route which has been patented and is currently being scaled up commercially.It has a unique processing feature in allowing simple selection of R groups and it is proposed to use this to bond directly to the copper nanoparticles, resolving the issue of leaching.The objectives of the project of the project are: 1.Develop a copper nano-particle production process 2.Functionalise silsesquioxanes with copper using Vitolane technology 3.Produce a commercially acceptable coating 4.Validate coating in a hospital environment","Nano-structured copper coatings, based on Vitolane technology, for antimicrobial applications",FP7,31 December 2013,01 October 2010,1000000.0 CVM-EM-PALM,Pasteur Institute * Institut Pasteur,health,"Electron microscopy (EM) is an invaluable tool for investigating the nanometer-scale organization of molecular assemblies such as viruses, but is restricted to dead cells, does not readily label targeted proteins, and is prone to fixation artefacts. Recently developed methods to break the diffraction limit in optical microscopy have the potential to resolve protein arrangements in living cells. However, their resolution is currently restricted to ~20-30 nm, still an order of magnitude removed from EM, and dynamic super-resolution imaging remains challenging. Here, we aim to reconstruct the protein arrangements of molecular structures at resolutions better than 20 nm by harnessing the power of statistics, i.e. by aggregating images from hundreds or thousands of copies of nearly-identical structures and when possible by exploiting their symmetry. To do this, we will adapt computational methods of single particle reconstruction from electron microscopy to super-resolution optical microscopy. After validation on synthetic data, we will test and apply these methods to nuclear pores and adenovirus capsids. These examples have been chosen because of their geometric features that work well with our approaches. Particularly, we are interested in obtaining novel insight into the dynamic structural changes occurring at the nuclear pore complex during active transport. Furthermore, we aim to decipher the sequence of events during viral capsid formation. This work has the potential to further push the resolution of optical microscopy towards that of electron microscopy for the analysis of ordered molecular assemblies. If successful, our project will open the door to structural investigations in living cells, including the assembly process of viral particles, or the plasticity of the nuclear pores and its role in nucleo-cytoplasmic transport.",Computing the structure and dynamics of protein assemblies in living cells by coupling sub-diffraction fluorescence microscopy with single-particle reconstruction: application to viral capsids,FP7,02 December 2011,03 May 2010,165645.0 CYANOBAC-RESPIRATION,Queen Mary University of London,health,"Photosynthesis and respiration are two of the most important biological processes on Earth for energy supply. Cyanobacteria can perform both oxygenic photosynthesis and aerobic respiration in thylakoid membrane. However, compared to extensively studied photosynthesis, knowledge of respiration is not satisfactory. So far, the long-range organization and mobility of respiratory complexes have never been investigated, and how photosynthesis and respiration are regulated in vivo is unknown. This project aims to determine the spatial distribution and mobility of respiratory systems in cyanobacteria, and to elucidate the interaction and regulation of respiratory and photosynthetic electron transport chains in thylakoid membrane. The first aim is to construct cyanobacterial strains containing respiratory complexes tagged with GFP and mCherry. Then high-resolution fluorescence confocal microscopy and fluorescence recovery after photobleaching allow to study the distribution and mobility of fluorescently tagged respiratory complexes and naturally florescent photosynthetic proteins. To supplement the fluorescence observations, using electron microscopy and scanning probe microscopy, this project will further examine the supramolecular organization of photosynthetic and respiratory complexes in thylakoid membrane at the molecular level. Based on the in vivo and in vitro findings, it is possible to draw a picture of the large-scale distribution of respiratory and photosynthetic complexes in vivo at the level of individual complexes, and to explore the coordination and regulation between photosynthesis and respiration. Advanced understanding of the bioenergetic pathways will practically benefit biofuel and biodiesel engineering, to exploit and improve renewable energy production by controlling the complex pathways of electron transport in photosynthetic organisms. The interest of the interdisciplinary project covers molecular biology, biochemistry, biophysics and nanotechnology.",Organization and Dynamics of Respiratory Electron Transport Complexes in Cyanobacteria,FP7,31 July 2012,01 August 2010,179603.0 CYCLON,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"There is a high demand for the development of new drug delivery strategies to combat major diseases in our society, particularly cancer. Current treatments are based on high efficacy drugs, however their non-selective uptake by both normal and tumor cells as well as the development of multidrug resistance (MDR), constitute major hurdles. Resistance is also associated with the use of nucleoside analogues as anticancer drugs in vivo. Photodynamic therapy (PDT), aims at selectively killing neoplastic lesions by the combined action of a photosensitizer and visible light. Passive targeting, involving enhanced permeability and retention effect, allows the accumulation of drugs on tumor sites, and concomitant active targeting with suitable functionalities, constitute properties currently associated with polymeric delivery systems. Cyclodextrins (CDs) are biocompatible and biodegradable oligosaccharide nanocages, known to improve the solubility, stability and bioavailability of drugs. Scattered literature reports incidents that CDs may constitute potential means to overcome certain forms of MDR, or to effectively deliver photosensitizing anticancer drugs preserving their photodynamic properties. This network, highly specialized in CD chemistry, photochemistry, in vitro drug evaluation and in vivo applications, proposes to synthesize diverse families of new CD derivatives to build a platform of CD-based drug delivery nanosystems with a variety of architectures. These new generation nanocarriers, encompassing many cavities in a nm-sized vehicle, will possess high drug loading capacity, improved permeability and retention effect, enhanced targeting and complete biocompatibility. Their mode of action will be assessed in vitro and in vivo. These goals will be achieved via a strong training program of ESRs and ERs in a highly collaborating, multidisciplinary and application oriented program, with full participation of an SME partner, a leader in CD applications.",Novel multifunctional cyclodextrin-based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks.,FP7,30 September 2013,01 October 2009,2415547.0 CYCLON HIT,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The worldwide spread of antibiotic-resistant microorganisms can be viewed as an ecological consequence of the systematic use of antimicrobial agents. Resistant bacteria prevail in healthcare environments where antibiotic selective pressure is intensive. Novel therapeutic approaches are urgently required to deliver the well-documented existing drugs in an optimized fashion to: i) protect them toward degradation; ii) increase their bioavailability; iii) reduce toxic side effects; iv) increase patient compliance and iv) reduce treatment duration and related costs. In this sense, nanocarriers based on cyclodextrins (CDs) are particularly appealing for the delivery of antibiotics. This approach is of main interest for tuberculosis (TB), infections related to Salmonella Typhimurium, Staphyloccocus aureus and for species most frequently implicated in hospital infections such as enteric gram-negative rods. We will design and characterize CD-based nanocarriers, test their ability to encapsulate drugs, study their efficacy in vitro on bacteria and infected cells. The best formulation will be tested in vivo and scaled up. The objectives of the CycloN Hit project are to take full advantage of nanotechnology and of the high level interdisciplinary expertise of the partners to efficiently encapsulate and protect antibiotics in nanocarriers to combat resistant bacteria, and study the mechanisms in biological systems using state-of-the art techniques. This will be accomplished through a strong and demanding training program for 11 Early Stage and 5 young Experienced Researchers which will gather interdisciplinary expertise of 11 Full partners and 6 Associated partners, of which 7 are SMEs. Using the most recent advances in the nanomedicine field, the final goal of the CycloN Hit project is to bring to the preclinical studies an antibiotic formulation for the treatment of TB and more tailored alternative therapeutic approaches for other resistant microorganisms.",NANOCARRIERS FOR THE DELIVERY OF ANTIMICROBIAL AGENTS TO FIGHT RESISTANCE MECHANISMS,FP7,28 February 2018,01 March 2014,3894894.0 CYLREC,University of Birmingham,health,"The scientific aim of this proposed project is to understand what features of nanoscale synthetic cylinders, and which biomolecular binding mode, give rise to the observed biological effects on the cell cycle and to probe the mechanism and temporal relationships of that action in more detail. Our hypothesis is that the cylinder recognition of Y-shaped junctions, particularly replication forks, is a key feature of their action. The new design strategies will create cylinders which deconvolute the two different DNA binding modes (Y-shaped junction or major groove) and are founded on careful analysis of the X-ray structure of the 3 way junction and an NMR structure of the major groove binding: the designs add functionality to prevent one of these two binding modes while permitting the other. Within each overall design strategy, a number of different cylinders are proposed and, as detailed, the results of the biophysical and cell delivery studies will be used to optimise the design and select the most suited.",Novel Supramolecular cylinders and their interaction with DNA; probing effects of cylinder structure and targeting DNA junctions,FP7,31 May 2012,01 June 2010,180603.0 CYPEPUTICS,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"Peptide macrocycles can bind with high affinity and selectivity to protein targets and are an attractive class of molecules for the development of therapeutics. Recently, a phage display-based strategy was developed that allowed to generate potent bicyclic peptide antagonists (Heinis, C., et al., Nat. Chem. Biol., 2009). While bicyclic peptides with nanomolar affinities to a range of protein targets could be generated, it was more difficult to obtain high-affinity binders to some proteins, particularly to those having flat surfaces and no clefts or cavities. Herein, I propose to develop rigid, tricyclic peptides that should, due to a more defined three-dimensional structure, bind to flat surfaces similar as antibodies. Two formats are envisioned for the synthesis of tricyclic peptides: in the first one, a linear peptide is anchored via four cysteine residues to a small molecule while in the second format, bicyclic peptides will be generated and their two peptide rings are connected via Huisgen cycloaddition reaction to impose an additional conformational constraint. Phage-encoded combinatorial libraries of these peptide folds will be generated and subjected to affinity selections. Tricyclic peptide binding to a variety of biological targets including (a) the well-characterized cancer-associated targets EGFR and HER2, and (b) the more challenging target of the antibiotic vancomycin, the short peptide D-Ala-D-Ala, will be developed.",Tricyclic Peptides for the Development of Therapeutics,FP7,31 May 2016,01 June 2014,199317.0 D-DOT FET,Juelich Research Centre * Forschungszentrum Jülich,manufacturing,"The goal of the proposed research is the evaluation of an entirely new path to fabricate strained Si nano-devices which are compatible to Si CMOS processing. The idea is to fabricate field effect transistors from strained Si bridges, which have been manufactured by disposing embedded, sacrificial Ge islands (dots). To achieve the required positioning of the Ge dots, templated self assembling will be explored. This approach promises high speed electronics, due to the large mobility of carriers in strained Si, substantially reduced short channel effects, since the thickness of the channel is defined by an air bridge, and an improved thermal conductivity, which is attributed to the all Si device design. Alternative paths for the templated self assembly of Ge dots will be investigated, including e-beam lithography and x-ray interference lithography for the pre-pattern and molecular beam epitaxy as well as chemical vapour deposition for the growth of the ordered Ge islands. Care will be taken to analyse by grazing incidence x-ray diffractometry the strain and its uniformity in the Si bridges before and after removal of the Ge dots as well as after the fabrication of the gate stack. The actual devices will be processed using CMOS compatible Si device technology. The fabrication of the devices will be accompanied by intensive structural and electronic modelling. Special emphasis will be put on the strain distribution in the Si channel prior and after the removal of the dots and its impact on the electronic properties of the devices.To tackle this complex multi-faceted project experts in the field of crystal growth, structural and electronic analysis, device processing, modelling of crystal growth and device simulation will closely cooperate. As a result detailed insights into the correlation between structural and electronic properties in Si nano-electronic devices are expected as well as the successful fabrication of this new device - the disposable dot FET.",Disposable Dot Field Effect Transistor for High Speed Si Integrated Circuits,FP6,30 September 2009,30 September 2005,2000000.0 DAISY,National Institute of Health and Medical Research * Institut National de la Santé et de la Recherche Médicale (INSERM),information and communications technology,"The neocortex of higher mammals like carnivores and primates has a lattice-like network of local circuits embedded within inter-areal connections, which together form the 'daisy architecture' (DA). Our hypothesis is that the DA supports self-organized, context-dependent processing. Data derived from quantitative neuroanatomy and high spatio-temporal resolution imaging of cortical activity will be used to test theoretical predictions about the possible mechanisms and function of the DA. Understanding this architecture, and its computation will have two major benefits: Firstly, it will contribute to our understanding of how the brain reasons, and so will have important implications for mental health. Secondly, if the structure and dynamics of the DA could be reverse engineered it would be a major advance in Information Technology by offering novel methods for scalable, distributed, autonomous computation. We explore two candidate models of computation on the DA: graphical models such as Bayesian Networks and Factor Graphs that factor complicated global functions into a product of simpler ones and Dynamic Link Architectures that encode and recognize objects by dynamic composition of neuronal interactions. We implement these computational styles in hybrid analog/digital CMOS VLSI circuits, which contribute to the 'End of Moore's Law Problem' by demonstrating how existing CMOS technology could be more efficiently deployed than in clocked digital systems. We explore the semantic nature of the biological computations by imaging the activity of cortical neurons as they respond to perceptually significant stimuli and evaluate our hypotheses about the DA by constructing object recognition systems that extract meaningful invariances from examples. These results would considerably advance our understanding of computation by the neocortex and provide a novel architecture in which implicit world semantics could be incorporated into computation.",Neocortical Daisy Architectures and Graphical Models for context-dependent Processing,FP6,28 February 2010,28 August 2005,3626000.0 DAIX,Imperial College London,health,"The principal objective of this grant is to develop via the Transfer of Knowledge Marie Curie Action a state of the art compact table top X-pinch device. The x-ray emission of the X-pinch generator will be in the range of 1-10 keV, the total x-ray power will be 1kW and will be investigated as a function of the pulsed current, the wire material and the material size. Emphasis will be given to investigate the physics of the formation of the dense hot plasma at the cross-point and the radiation transport. The self-generated magnetic field in the overdense region of the x-ray point source will be diagnosed using a novel technique based on the Faraday rotation of a probe laser pulse and the Cotton-Mouton effect on XUV harmonics generated by a femtosecond laser system. Applications of x-rays in science, industry and medicine will be explored. In particular, x-ray lithography for new semiconductor material research for nanotechnology purposes and x-ray radiography and microscopy of biological cells will be performed. The proposed work envisaged will provide excellent Transfer of Knowledge opportunities from world leading Universities and Research Centers (Imperial College, Rutherford Appleton Laboratory, University of California) to a less favoured region (Crete) in need of developing new areas of competence and knowledge in the field of pulsed power technology and x-ray sources.",Development of An Innovative X-ray source,FP6,28 February 2009,01 March 2005,940174.0 DAMASCO,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"Organic Photovoltaics have advantages compared to traditional inorganic solar cells, offering the prospect of low fabrication cost and flexiblility. The properties of organic and polymeric materials, open the perspective of a widely distributed photovoltaic low cost mass production. For this development to take place, the devices power conversion efficiency have to reach 10% and their lifetime have to increase. The development of polymer based solar cells has made significant progress but more research in the design and synthesis of new photoactive organic materials is needed. Bulk-heterojunction (BHJ) organic solar cells have active layers composed by electron-donating p-type semiconductors and electron-acceptor n-type materials. DAMASCO project will contribute to the design, synthesis and testing of new electron acceptor molecules and polymers with n-type properties for organic BHJ solar cells. Perylene diimides dyes are a significant class of n-type organic semiconductors for optoelectronics. These materials have good thermal and photochemical stability, high electron affinity, high absorption and their electronic properties can be easily modified via chemical tailoring by introducing substituent groups. Due to these properties, perylenes are candidates for organic photovoltaics. DAMASCO will develop novel perylene based molecules and polymers with n-type semiconduction properties and good solar harvesting. DAMASCO project has the following objectives: 1) design and synthesis of novel electron acceptor perylene based systems; 2) preparation and characterization of polymeric donor/acceptor photoactive blends; 3) assembling of BHJ solar cells and photovoltaic performance evaluation. The expected results are: a) new highly stable molecules and polymers with n-type semiconduction properties; b) nanostructured photoactive layer made of polythiophenes and perylene acceptor systems; c) BHJ solar cells with good harvesting of the solar light and longer live time.","Preparation and Application of new n-type, Electron Acceptor Materials in Organic Solar Cells",FP7,28 February 2014,01 March 2011,45000.0 DANCER,University of St Andrews,photonics,"A key challenge for the 21st century is, therefore to provide billions of people with the means to access, move and manipulate, what has become, huge volumes of information. The environmental and economic implications becoming serious, making energy efficient data communications key to the operation of today's society. In this project, the Principal Investigator will develop a new framework for optical interconnects and provide a common platform that spans Fibre-to-the-home to chip-to-chip links, even as far as global on-chip interconnects. The project is based on the efficient coupling of the Photonic Crystal resonators with the outside world. These provide the ultimate confinement of light in both space and time allowing orders of magnitude improvements in performance relative to the state of the art, yet in a simpler simple system- the innovator's dream. New versions of the key components of optical links- light sources, modulators and photo-detectors- will be realised in this new framework providing a new paradigm for energy efficient communication.",DAtacommunications based on NanophotoniC Resonators,FP7,30 November 2018,01 December 2013,1495450.0 DAPOMAN,Technical University of Madrid * Universidad Politécnica de Madrid,energy,"Block copolymer materials have been shown to self-assemble into a variety of morphologies, some which exhibit complex and intricate nanometer scale structures. That attribute has led researchers to propose material and device fabrication strategies. The majority of synthetic, characterization, and theoretical work on block copolymers has focused on their bulk behavior. A smaller effort has focused on the study of multiblock copolymers, their mixtures with homopolymers and nanoparticles under confinement. Complex morphologies have been elucidated with the help of theoretical models and theoretically predicted phase diagrams have often provided much needed roadmaps for experimentalists. Available theoretical and computational approaches face considerable challenges when trying to describe large 3-dimensional multiblock copolymer samples, nanoparticle-copolymer composites, confined copolymers and composites and the effects of fluctuations on such systems. The central idea of our proposed work is to direct the assembly of thin copolymer films by creating nanoscale patterns on substrates that the polymer can recognize. Past work has shown that it is possible to achieve perfect, defect-free registration between block-copolymer morphology and a nanoscale surface pattern over macroscopic length scales. The goal is to use directed assembly as a platform on which to improve a molecular-level understanding of block copolymers and copolymer nanocomposites through the systematic application of external, molecular-level constraints that induce well defined responses. The applied, technological goal is to create a multi-scale theoretical and computational formalism that will facilitate study of confined block copolymer-based systems, and guide development of efficient nanofabrication strategies for large-scale production of materials and devices such as those already encountered in the semiconductor industry or those encountered in the photovoltaic and energy storage industries",Directed Assembly of Polymeric Materials Nanofabrication,FP7,30 November 2010,01 June 2009,164473.0 DARWIN,University of Leuven * Katholieke Universiteit Leuven,health,"Wireless and mobile communication systems have become an important part of our daily environment. Since the introduction of the GSM-network in the early nineties, different wireless applications such as WiFi, Bluetooth, GPS, etc. have been brought into the market. This has become possible due to the high integration of integrated circuits in relatively cheap technologies. Besides the digital signal processing, those wireless applications require complex analog circuits operating at very high frequencies (RF circuits). In the early days these were implemented as discrete components or standalone ICs in expensive technologies such as GaAs, InP and SiGe. Due to the research towards nanometer CMOS technologies, and due to improved RF circuit techniques, RF-CMOS has been introduced since the mid nineties. The intention of this research project is to take the next big leap forward in wireless applications, i.e. the exploration and research, based on the vast RF-CMOS knowledge already existing, towards the Extremely High Frequencies which is above 70 GHz up to 300GHz, with wavelengths close to 1 mm. The research project is a logical evolution of the RF-CMOS research knowledges of the team. For that the "natural evolution" acronym DARWIN (Deep mm-Wave RF CMOS Integrated Circuits (with the M of CMOS inverted (W)) is choosen. Implementing circuit techniques in standard CMOS technologies at those frequencies is again an enormous challenge and will open a lot of new opportunities and applications towards the future due to possibilities in safety monitoring, e.g. collision radar detection for automobiles at 77 GHz, the need for high data-rate telecommunication systems, with capacity of 1-10 Gbps, and imaging for medical and security systems. The goal of the proposed project is to perform the necessary fundamental basic research to be able to implement these 70-300 GHz applications in CMOS technology (45 nm and below).",Deep mm-Wave RF-CMOS Integrated Circuits,FP7,31 December 2013,01 January 2009,2042640.0 DAVID,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"The DAVID project targets to provide an extremely high packaging density for hybrid integration of MEMS with ASICs. A significant reduction of assembly and packaging costs, specifically for consumer applications, shall be reached by the integration approach itself, but also by a lithographic size reduction of micromachined structures. The benefit becomes most visible when several sensors are clustered in a single, hermetic encapsulation on wafer level. Beyond this, a '3D-SiP' approach can improve product quality by reducing parasitic effects: DAVID's extremely short interconnects are particularly interesting for capacitive or high-frequency signals. The project is designed to demonstrate a complete process flow with the following technology components: - vertical interconnect by post-CMOS feedthroughs - handling, assembly and waferlevel bonding of singulated, open MEMS devices on a CMOS wafer - vacuum sealing and fine structured getter films to control the sensor cavity ambient - waferlevel molding and solder balling to build a chip-scale MEMS-SiP. Critical aspect like mechanical drift and offset effects of package stress are addressed by the implementation of a test vehicle that allows to measure and correlate them with FEM simulations. A control of design and material suitability is therefore given through all process stages. The project consortium forms a representative industrial environment: ST Microelectronics as a large semiconductor manufacturer acts close to high-volume market requirements. Datacon Technology and Besi Molding provide industrial equipment for assembly and packaging. SAES Getters is a renowned service provider in vacuum technology. Research and design support is given by Fraunhofer ISIT and Wroclaw University of Technology.",Downscaled Assembly of Vertically Interconnected Devices,FP6,30 June 2009,30 December 2005,2799761.0 DCENSY,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"We target a frontier in nanocrystal science of combining disparate materials into a single hybrid nanosystem. This offers an intriguing route to engineer nanomaterials with multiple functionalities in ways that are not accessible in bulk materials or in molecules. Such control of novel material combinations on a single nanoparticle or in a super-structure of assembled nanoparticles, presents alongside with the synthesis challenges, fundamental questions concerning the physical attributes of nanoscale systems. My goals are to create new highly controlled hybrid nanoparticle systems, focusing on combinations of semiconductors and metals, and to decipher the fundamental principles governing doping in nanoparticles and charge and energy transfer processes among components of the hybrid systems. The research addresses several key challenges: First, in synthesis, combining disparate material components into one hybrid nanoparticle system. Second, in self assembly, organizing a combination of semiconductor (SC) and metal nanoparticle building blocks into hybrid systems with controlled architecture. Third in fundamental physico-chemical questions pertaining to the unique attributes of the hybrid systems, constituting a key component of the research. A first aspect concerns doping of SC nanoparticles with metal atoms. A second aspect concerns light-induced charge transfer between the SC part and metal parts of the hybrid constructs. A third related aspect concerns energy transfer processes between the SC and metal components and the interplay between near-field enhancement and fluorescence quenching effects. Due to the new properties, significant impact on nanocrystal applications in solar energy harvesting, biological tagging, sensing, optics and electropotics is expected.","Doping, Charge Transfer and Energy Flow in Hybrid Nanoparticle Systems",FP7,31 May 2015,01 June 2010,2499000.0 DCN,Rijksuniversiteit Groningen * University of Groningen,health,"Recent developments in genomics and proteomics have generated an urgent need for new methods of interrogating and targeting biochemical networks. In particular new means of interfering with protein-protein interactions are in high demand and of considerable therapeutic potential. New materials are needed that can recognise and bind to specific protein surfaces. We aim to develop a new approach to the recognition of proteins using individual nanoparticles and dynamic networks of nanoparticles. This requires the development of: 1. Functional nanoparticles capable of selectively recognising proteins. We will explore the potential of dynamic combinatorial chemistry to direct the functionalisation of the surface of the nanoparticles. 2. A means of translating nanoparticle-protein interactions into a signal. Our approach is to use nanoparticle networks that respond to the presence of proteins with a redistribution of their surface functionalisation, which, in turn, produces an optical readout through fluorescence resonance energy transfer. The project is critically dependent on the host's expertise on dynamic combinatorial chemistry and the applicant's expertise on the characterisation of nanostructures. The expected outcome is a conceptually new means of interfacing functional nanoparticles with biomolecules, based on an innovative molecular network approach. This systems chemistry strategy breaks with the reductionist tradition that has characterised most research in chemistry for the last centuries.",Dynamic Combinatorial Nanoparticles for Protein Surface Recognition,FP7,31 December 2011,01 January 2010,169992.0 DEBUG,"Athens University of Economics and Business, Research Center",health,"Computer VLSI chips prevail in nearly every aspect of the daily lives of modern Europeans. The respective industry is also an integral part of the prosperity of the EU economy. Every modern electronic device (computers, phones, satellites, medical devices, automobiles, etc) contains a number of integrated circuits (or chips) comprised of hundreds of millions of nanoscale size functional elements in a very small silicon area. Due to reliability and strict time-to-market concerns, the community is challenged to design such complex devices, remain competitive and guarantee their correct functionality. This project encompasses three targets. First, it will develop state-of-the-art automated tools to enhance the verification process by debugging errors in real industrial designs. It will also examine the possibility to commercialize these results with European industry. To do this, we collaborate with two major industrial partners, OneSpin Solutions (Infineon) in Munich and Intracom Telecom in Greece. As such, the second target will bring closer the industry to academia and it will develop an FPGA-driven state-of-the-art laboratory to train new workforce. As a third target, this project will assist the PI, who has a 15 years education and work experience in top places in N.America and who assumed a full-time position in a European institution, to reintegrate back with the EU research workforce and strenghten ties with European industry.",Automated correction methodologies for the design of high performance modern microprocessor integrated chips.,FP6,30 September 2009,01 October 2007,80000.0 DECENT AID,Abnoba GmbH,health,"Drug delivery systems are a matter of intensive scientific investigation and technological developments. They are necessary since many active pharmaceutical ingredients to be employed in therapy, diagnostics or vaccination cause serious side effects when distributed non-specifically. Without a drug delivery system, the active pharmaceutical ingredients may accumulate in healthy and sensitive tissue, provoke adverse immune reactions, have poor solubility, low bioavailability and inefficient targeting. To meet these challenges, the key objectives of the proposed project are the development and testing of an innovative production technology for nanocapsules as a drug delivery system using centrifugation, colloidal and fluid mechanical techniques. These novel nanocapsules should be especially suited for proteins and other sensitive biomolecules which are vulnerable to degradation by existing encapsulation technologies. An immune protection consisting of a suitable polymer cover of the nanocapsules has to be developed to enable long circulation in human blood without provoking innate immune reactions by the complement, the coagulation and the phagocytic systems. Other than established polymer protection systems, the novel polymer protection should not be immunogenic to avoid accelerated blood clearance upon repeated administration. The nanocapsules have to prove to be sufficiently stable in human blood ex vivo. In vitro and in vivo tests in cancer models will be performed to compare drug efficiency, immune reactions and organ distribution of encapsulated and non encapsulated active pharmaceutical ingredients. Multidisciplinary research and innovation for nanomedicine is aimed for by collaboration in an intersectoral research team comprising mechanical and process engineering, pharmaceutical technology, immunology and cancer research.",Novel drug delivery system produced by centrifugal technologies -composed to minimize adverse immune reactions and designed for optimised therapeutic effects,FP7,31 March 2017,01 April 2013,1492545.0 DECIMA,The University of Edinburgh,manufacturing,"The Project aims to develop novel approaches for detection and characterization of particles in the critical nanometer – micrometer size range. An improved knowledge of the make-up and origin of such particles that are present in the atmosphere and working environments is crucial for understanding their role in atmospheric pollution and human health. The role of atmospheric particles in influencing climate behavior is also poorly understood and requires more sophisticated analysis techniques. The detection of neutral isolated nanoparticles is an extremely challenging problem. The compositions and structures of particles present in the atmosphere are largely unknown owing to limited measurement capabilities. Recently it has been shown that femtosecond laser ablation is a promising technique for nanoscale depth-resolved chemical analysis while graphene nanoresonators offer much promise as ultrasensitive mass detectors. This multidisciplinary Project includes two key areas that could revolutionize particle monitoring: (1) depth-resolution analysis of micro- and nanoparticles using fs laser ablation mass spectrometry and (2) the combination of nanoelectromechanical mass sensing and fs laser ablation mass spectrometry for the detection and elemental analysis of neutral nanoparticles. A dual time-of-flight mass spectrometer will be constructed for analysis of individual aerosol particles. The potential of fs-laser ablation mass spectrometry for providing a particle depth profile will be explored and tested on well-defined core-shell micro-/nanoparticles. In addition, the elemental analysis potential of fs laser ablation mass spectrometry will be coupled with sensitive neutral particle detection, using a graphene-based mass sensor that will be developed in the host group. The outcome of the Project will be in making an important step from fundamental concepts of particle detection and characterization to laboratory proof-of-principle studies and prototype development.",Detection and Characterization of Individual Micro- and Nanoparticles,FP7,10 April 2015,10 May 2013,278807.4 DECIPAIN,Natural and Medical Sciences Institute (NMI) at the University of Tübingen,health,"Chronic and neuropathic pain, usually diagnosed as spontaneous pain, hypersensitivity to pain or both, is a maladaptive response of the organism to injury and inflammation. Finding new effective drugs to treat these debilitating conditions has shown particularly difficult, as compounds showing good efficacy in preclinical models often fail to meet clinical trials endpoints. A commonly accepted explanation for this discrepancy is that virtually all preclinical analgesic tests have only limited predictability, as they are based on models of evoked pain, whereas patients mainly seek relief of spontaneous pain. To fill the gap in our knowledge of the mechanism of spontaneous pain and to accelerate the discovery process towards better analgesics, we propose to implement a new in vivo platform for deciphering pain pathways in animal models of spontaneous pain. A new electrophysiological approach, high throughput microneurography (HT-MNG) will be implemented by using in house nanotechnology and microelectronics. This approach will be combined with in vivo RNA interference and optogenetics and validated by specifically addressing targets known to be involved in chronic and neuropathic pain conditions. The proposed preclinical in vivo platform has a great translational potential, as HT-MNG recordings from animal models will provide data directly comparable to those from human patients. Thus, we expect our project to significantly contribute in avoiding expensive failures in Phase II and Phase III pain studies due to lack of drug efficacy. Moreover, by opening the possibility to measure and recognize specific excitability patterns in peripheral neuropathies, the project can help identify patients more likely to respond to a particular drug, dose or regime, thus opening new opportunities for personalized medicine.",An integrated approach towards drug discovery and target validation for pain,FP7,31 August 2016,01 September 2012,100000.0 DECNAHED,Institute of Solid State Physics * Latvijas Universitātes Cietvielu fizikas institūts,energy,"This project will deal with development of new materials for emerging hydrogen and fuel cell technologies using nanotechnology approach. Main focus will be to develop low price novel composite inorganic/polymer membranes for electrolyser and fuel cell (PEM/DMFC) applications. The basic approach is to use a novel procedure for double cross-linking of sulfonated PEEK in order to improve the membrane stability and electrochemical performance in FC (patent application is submitted). The synthesis procedure is simple and it will not involve any expensive, and harmful and corrosive components. The membrane will be modified by adding inorganic nanoparticles and blending with polybenzimidazole (PBI). Standard characterization methods for membranes will be applied. Morphological studies and electrochemical and spectroscopic methods will be used as a basic ones for this project. However, from practical point of view the components are embedded in a macrosystems (fuel cell, electrolyser, battery) and they are exposed to real working conditions of device, which might include high electric current flow and high electric field gradient. It is limiting long term stability. About 0.1% power decrease per 1000 hrs is generally accepted for stationary applications, which is difficult milestone for nanomaterials. In this project the main focus will be on integrated approach. The membrane-electrode assembly (MEA) will be produced and material properties will study from point view of working assembly. In our Project the complex approaches combining aspects of device physics and nanotechnology and using multiphysics modeling will be used to address similar complex problems. Multiphysics modeling software Comsol will be applied in order to specify the device performance conditions and reactor designs under which the MEA degradation is minimized. Effort is planned to link the multiphysics modeling with practical experiment.",Development of Composite Nanomaterials for Hydrogen Energy Devices,FP7,30 September 2012,01 October 2008,100000.0 DECODEB,Rovira i Virgili University * Universitat Rovira i Virgili,health,"Defined spatial distribution of proteins plays a major role in nature, like structures for bacterial cell mobility (Escherichia coli's flagella), capsid structures of viruses, structures for the controlled segregation of chromosomal DNA both in eukaryotic and prokaryotic cells, a large array of membrane protein complexes (e.g. protein transporters and nutrient transporters) and the assembly of channeled metabolic pathways among many others. All these diverse and fundamental processes are the result of the evolution of very specific and controlled spatial organization of multiple proteins. Defined spatial distribution also plays a major role in many biotechnological applications of proteins, from the immobilization of antibodies on the surface of an electrode for their use in biosensors to the creation of nanostructures through biotemplating. A wide variety of approaches have been developed in order to allow the easy immobilization of proteins, ranging from electrostatic interactions and direct covalent linkage to high affinity non-covalent interactions (e.g. streptavidin/biotin). In order to facilitate the generation of more complex synthetic quaternary protein structures (on surfaces and in solution), we propose the development of a protein fusion tag system that will enable the controlled and orderly precise co-immobilization of proteins by means of protein-DNA interactions. This project aims to take advantage of the highly developed methodologies that currently exist and allow the synthesis and immobilization of DNA with ease and use them as a means for controlled protein co-immobilization. Specifically, to achieve this objective, we propose to develop a panel of high affinity DNA binding proteins with different sequence specificities to be used as fusion tags and provide the protein-DNA interaction link.",Defined co-immobilization by DNA binding protein tags,FP7,30 November 2015,01 December 2011,100000.0 DECOHERE-SPINTRONIC,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"We plan to consider the effect of decoherence on quantum effects in nanoscale spintronic devices. This will further our understanding of quantum mechanics (entanglement, tunneling, Onsager relations, Kondo physics, etc) in the presence of decoherence. We investigate how decoherence destroys these quantum effects allowing classical mechanics to emerge. In particular we ask when this crossover involves quantum phase transitions, and what determines the universality class of these transitions. We will concentrate on solving models with relevance to experiments in nanoscale spintronics. We will work in collaboration with experimentalist to ensure these models are realistic. The problems we consider will have significant practical applications, improved understanding of decoherence in spintronics will enable the development of decoherence-resistant devices. This proposal will greatly broaden and enhance the experience of the candidate, enabling him to achieve a position of professional maturity and independence. The skills he develops will be extremely useful in the growing field of spintronics, and in nano-science more broadly.","ENTANGLEMENT, DECOHERENCE AND PHASE TRANSITIONS IN NANOSCALE SPINTRONICS",FP6,31 August 2007,01 September 2005,0.0 DECORE,University of Padua * Università degli Studi di Padova,health,"The main general goal of DECORE is to achieve the fundamental knowledge needed for the development of a fuel cell (FC) electrode, which can operate efficiently (both in terms of activity and selectivity) as the anode of a direct ethanol (EOH) FC (DEFC) in the temperature range between 150-200 °C (intermediate-T). Such a technology is still lacking in the market. The choice for EOH as an alternative energy source is well founded on the abundance of bioethanol, and on the relatively simpler storage and use with respect to other energy carriers. The intermediate-T is required for an efficient and selective total conversion of EOH to CO2, so exploiting the maximum number of electrons in the DEFC. DECORE will explore the use of fully innovative supports (based on titanium oxycarbide, TiOxCy) and nano-catalysts (based on group 6 metal carbides, MCx, M = Mo, W), which have never been tested in literature as anodes for DEFCs. The new support is expected to be more durable than standard carbon supports at the targeted temperature. The innovative nano-catalysts would be noble-metal free, so reducing Europe's reliance on imported precious metals. To tailor the needed materials, the active role of the support and nano-catalyst will be studied at atomic level. Demonstrating an activity of such nano-catalyst/support assembly at intermediate-T would open a novel route where DEFCs with strongly reduced production costs would have an impact on a fast industrialisation. The power range for the envisioned application is of the order of hundreds of Watts, i.e. the so called distributed generation, having an impact for devices such as weather stations, medical devices, signal units, auxiliary power units, gas sensors and security cameras. By the end of the project, a bench-top single DEFC operating at intermediate-T will be built and tested.",Direct ElectroChemical Oxidation Reaction of Ethanol: optimization of the catalyst/support assembly for high temperature operation (DECORE),FP7,31 December 2016,01 January 2013,2341664.0 DEDOM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"First principles Density-Functional Theory (DFT) methods have been widely applied for computing electronic and optical properties of different systems. Recently theoretical modeling of metal-organic interfaces received a much attention due to their importance in different nanoscience fields. However, common (i.e. local and semi-local) approximations to the exchange-correlation (XC) functional of DFT show several shortcomings in describing metal-organic energy-levels alignment and thus charge-transfer. Aim of the DEDOM (DEvelopment of Density functional theory methods for Organic Metal interaction) project is to elaborate new theoretical methods beyond the current state-of-the-art for the description of the electronic and optical properties of organic molecules linked or deposited on metal surfaces or metal nanoparticles. This task includes: i) the development of new and efficient XC functionals, based on optimized effective potential (OEP) and including exact-exchange and correlation from many-body theory, to obtain an accurate description of charge-transfer between organic molecules and metal surfaces; ii) the investigation of optical properties, including light-emission, of organic molecules on metal surfaces using Time-Dependent DFT; iii) the description of metals using Green's functions and multi-scale approaches to investigate metal-induced modification of the optical properties of organic molecules, including fluorescence quenching or enhancement due to the coupling of electronic excitations to plasmons. The DEDOM project is theoretically and technically extremely challenging due to the use of unconventional orbital-dependent XC-functionals and it requires a strong interdisciplinary effort, joining solid-state physics, theoretical chemistry, electromagnetic engineering and implementation of advanced computational techniques. If successful, it will represent a major progress in the theoretical description of organic-metal interfaces.",Development of Density Functional Theory methods for Organic Metal Interaction,FP7,31 December 2013,01 July 2008,1250000.0 DEEPEN,University College Cork,photonics,"DEEPEN will develop an integrated open source multiscale simulation environment, targeted at problems common to future nanoscale electronic and photonic devices. New device simulators require an atomic-scale description of selected critical regions of a transistor or LED to capture details otherwise inaccessible. They must also resolve the considerable uncertainty in many critical parameters required for device optimisation. DEEPEN addresses both these issues, coherently combining state-of-the-art existing methods and developing new methodologies, integrated within a multiscale framework spanning from first-principles to macroscopic models. DEEPEN brings together leading groups with expertise not just in simulation, but also in its application to device design and optimization. It builds on Tyndall and ETHZ expertise in material and device properties, with experimental input from PDI also critical for validation of the multiscale models developed. Industry partners include a key multiscale modelling system provider (TiberLAB), a leading TCAD simulation provider (Synopsys) and an industrial end-user (Osram) who provide experimental validation and test the simulation environment for device design and investigation. Future code distribution will be supported through the project web site and through TiberLAB's existing support environment, www.tibercad.org. The nanoscale models to be developed address the challenging problem not just of predicting quantitatively electronic bands and quantum phenomena at the nanoscale, but also of linking these critical properties to overall device behaviour. The project emphasizes aggressive dissemination of results to maximize impact, including organization of Training Schools and an International Workshop, as well as the release and support of demonstration software and the open source interfaces. Overall, the project significantly strengthens European competitiveness, with clear routes to successful exploitation of the technology.",From atom-to-Device Explicit simulation Environment for Photonics and Electronics Nanostructures,FP7,31 December 2016,01 January 2014,2686000.0 DEEPNMDAR,IMEP-LAHC Laboratory,photonics,"Unrevealing the rules that govern the surface trafficking and membrane stabilization of neurotransmitter receptors, in particular the NMDAR is crucial for our understanding of several physiopathological brain processes. Over the past few years, scientists have shown that neurotransmitter receptors diffuse inside and out of synapses in cultured neurons using single molecule approaches. These findings drastically changed the way we understand synaptic transmission and adaptation. The proposed project aims to study the surface diffusion of NMDAR in intact hippocampal slices, providing the first functional map of such key receptors in native neuronal networks. Due to the difficulties of imaging single molecules in high background noise tissue, a multidisciplinary approach will be adopted using quantum dots and single walled nanotubes to track single NMDAR neurotransmitters. The success of the project will be a real breakthrough in neurobiology of synapses and in single molecule imaging techniques, conjugating state of the art knowledge in neurosciences and nanophotonics.",DEEP BRAIN TISSUE IMAGING OF GLUTAMATE NMDAR,FP7,30 June 2015,01 July 2013,194046.0 DELIGHT,TUT Foundation - Tampere University of Technology * TTY-Säätiö - Tampereen Teknillinen Yliopisto,manufacturing,"The 'Development of low-cost technologies for the fabrication of high-performance telecommunication lasers' project has two main objectives: (1) Development of high-performance surface-grating-based DFB/DBR telecommunication lasers (2) Development of ultra-high speed directly modulated lasers (> 40 GBit/s) with a simplified multi-section design, which exploit high-order photonic resonances for extending the modulation bandwidth. The project approach is to develop a common technological fabrication platform for both types of lasers based on surface gratings and other surface micro- and nano-structures. One important advantage in using surface structuring for increasing the performances and functionality of edge-emitting lasers is the elimination of the regrowth stage, which adds to the fabrication cost, affects the laser performances (notably the reliability and the characteristics shift in time) and reduces yield. The surface micro- and nano-structures will be imprinted by the low-cost and high-yield nanoimprint lithography, which will contribute to reducing the fabrication cost. The developed surface-oriented technology will be largely independent on the underlying semiconductor structure and will be applied for the fabrication of InP- and GaAs-based edge-emitting lasers (EELs) working in the 1300 and 1550 nm ranges. Although advanced materials (like dilute nitrides and antimony-containing dilute-nitrides) as well as low-dimensional structures (quantum dots and quantum dashes) will be investigated for developing the active regions of the lasers, the surface-oriented technology will be directly applicable to epitaxial layer structures already developed and tested in regular Fabry-Perot telecommunication EELs. Thus the developed surface-oriented approach will have the unique advantage of enabling the fabrication of higher-performance lasers from already tested and qualified 'legacy' epiwafers.",Development of low-cost technologies for the fabrication of high-performance telecommunication lasers,FP7,31 July 2012,01 September 2008,3300000.0 DELILA,Cardiff University,manufacturing,"The project 'Development of Lithography Technology for Nanoscale Structuring of Materials Using Laser Beam Interference (DELILA)' focuses on researching and developing a new production technology for fabrication of nano structures and devices. In particular, DELILA will enable low cost and large volume production of surface structures and patterns with nanometric resolution. Industrial end-users are currently discouraged from expanding their nanotechnology-related business activities by either unacceptably high costs or the impossibility to control production processes on a nanometric scale. DELILA will play a key role in realising the full potential of laser interference lithography as current nanofabrication tools are limited to archaic, slow processing rates, or do not achieve a competitive cost-effective strategy. DELILA is driven by industrial needs to down-scale feature sizes to nano dimensions, lower fabrication costs and efficiently increase throughput, with the following industrial and scientific objectives: (1)Fundamental exploration of multiple beam interference lithography and its capabilities; (2)Development of computer software for the analysis of interference of several coherent beams of laser radiation and for the calculation of the results of diffraction of the radiation by periodic structures of different forms; (3) Development of DELILA system. The main outcome of the project will be a nano fabrication tool that has the potential to create a breakthrough in nanolithography technology for both 2D and 3D structuring of materials. It is the aim of DELILA to empower interference nanolithography technology with a clear focus on industrial use. The main advantageous features of the DELILA system in fabrication of nano structures and devices are high resolution (better than 40 nm) compared with other optical technologies, and low cost and high efficiency compared with other beam technologies.",DEvelopment of LIthography Technology for Nanoscale Structuring of Materials Using LAser Beam Interference,FP6,31 March 2009,31 December 2005,1999999.0 DELPHINS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"The innovation of DELPHINS application will consist in building a generic multi-sensor design platform for embedded multi-gas-analysis-on-chip, based on a global modelling from the individual NEMS sensors to a global multiphysics NEMS-CMOS VLSI (Very large Scale Integration) system. The latter constitute a new research field with many potential applications such as in medicine (specific diseases recognition) but also in security (toxic and complex air pollutions), in industry (perfumes, agribusiness) and environment control. As an example, several studies in the last 10 years have demonstrated that some specific combination of biomarkers in breath above a given threshold could indicate early stage of diseases. More generally, patterns of breathing gas could constitute a virtual fingerprint of specific pathologies. NEMS (Nano-Electro-Mechanical Systems) based sensor is one of the most promising technologies to get the required resolutions and sensitivities for few molecules detection. We will focus on the analytical module of the system (sensing part + embedded electronics processing) that will include ultra-dense (more than thousands) NEMS arrays with state-of the art CMOS transistors. We will obtain integrated nano-oscillators individually addressed within an innovative architecture inspired from memory and imaging technologies. Few molecules sensitivity will be achieved thanks to suspended resonant nanowires co-integrated locally with their closed-loop and reading electronics. This would make possible the analysis of complex gases within an integrated portable system, which does not exist yet.",DESIGN AND ELABORATION OFMULTI-PHYSICS INTEGRATED NANOSYSTEMS,FP7,31 October 2014,01 November 2009,1723206.0 DELTA-MIN,University of Münster * Westfälische Wilhelms-Universität Münster,environment,"In this ITN we investigate the mechanism of mineral reequilibration (phase transformation) in the presence of a fluid phase in a wide range of minerals and rocks, under a range of chemical and physical conditions, using both natural and experimental samples. Interface-coupled dissolution-reprecipitation is a recently defined mechanism which applies to a wide range of mineral transformation phenomena. We apply these principles in individual projects to better understand the mechanisms of processes important in earth sciences and in industry, including metasomatic reactions in rocks, chemical weathering, mineral replacement mechanisms in CO2 sequestration, the aqueous durability of nuclear waste materials, remediation of contaminated water by mineral reaction, and the preservation of stone-based cultural heritage. The research methods bring together a range of complementary expertise, from field-related studies to nano-scale investigations of reaction interfaces using state-of-the-art high resolution analytical methods. The application of fundamental principles of mineral reequilibration to a wide range of applications, together with industrial involvement at all levels will ensure that the project provides a strong platform for training.",Mechanisms of Mineral Replacement Reactions,FP7,08 July 2014,09 January 2008,3109822.0 DEMCAMER,Fundación Tecnalia Research & Innovation,environment,The DEMCAMER project proposes an answer to the paradigm met by the European Chemical Industry: increase the production rate while keeping the same products quality and reducing both production costs and environmental impacts. Through the implementation of a novel process intensification approach consisting on the combination of reaction and separation in a “Catalytic Membrane Reactor” single unit.,Design and Manufacturing of Catalytic Membrane Reactors by developing new nano-architectured catalytic and selective membrane materials,FP7,06 June 2017,07 January 2011,0.0 DEMMEA,"Advent Technologies, SA",health,"The state of the art high temperature PEM fuel cell technology is based on H3PO4 imbibed polymer electrolytes. The most challenging areas towards the optimization of this technology are: (i) the development of stable long lasting polymer structures with high ionic conductivity and (ii) the design and development of catalytic layers with novel structures and architectures aiming to more active and stable electrochemical interfaces with minimal Pt corrosion. In this respect the objective of the present proposal is to understand the functional operation and degradation mechanisms of high temperature H3PO4 imbibed PEM and its electrochemical interface. The degradation mechanisms will be thoroughly studied and be focused on low loading Pt or nanostructured alloyed Pt electrocatalysts and catalytic layers, which will be supported on finely dispersed or structurally organized modified carbon supports (nanotubes, pyrolytic carbon). A stable electrocatalytic layer with full metal electrocatalyst utilization at the electrode/electrolyte interface can thus be achieved. The high temperature PEM membrane electrode assembly (MEA) will be based on a) PBI and variants as control group and b) the advanced state of the art MEAs based on aromatic polyethers bearing pyridine units. These MEAs have been developed optimized and tested at temperatures up to 200oC, where they exhibit stable and efficient operation. In the present proposal they will be studied and tested in single fuel cells with regards to their operating conditions and long term stability aiming to the development of a series of diagnostic tests that will lead in the design and development of an accelerated test and prediction tool for the MEA's performance. If we can really understand the fundamentals of the failure mechanisms, then we can use that information to guide the development of new materials or we can develop system approaches to mitigate these failures.",Understanding the Degradation Mechanisms of Membrane-Electrode-Assembly for High Temperature PEMFCs and Optimization of the Individual Components.,FP7,31 December 2012,01 January 2010,1638986.0 DEMOYS,Ricerca sul Sistema Energetico - RSE SPA,energy,"Membranes for oxygen and hydrogen separation play a key-role in the development of CO2 emission-free coal or natural gas power plants. In addition, cost-effective oxygen and hydrogen production processes are urgently needed in gas supply industry. Today existing membranes, however, are not able to meet the requirements for an economical use because of the high costs in combination with limited permeability values and long-term stability in the operating environment. The objective of this project is, therefore, the development of thin mixed conducting membranes for O2 and H2 separation by using a new deposition technique 'Low Pressure Plasma Spraying -Thin Film' (LPPS-TF) in combination with nanoporous, highly catalytic layers. TF-LPPS is a technique based on a combination of thermal spray and Physical Vapour Deposition technology. It allows the cost-effective production of thin, dense coatings on large areas at low substrate temperatures and has already successfully been used for the deposition of membranes for the solid oxide fuel cells. In this project both ceramic and metallic substrates will be used for deposition. It is expected that, by using the LPPS-TF process a dense, stable deposit with thickness lower than 20 micron can be obtained. This would allow to increase membrane performances while decreasing their manufacturing costs. Catalytic layers will be also applied to enhance the surface reactions becoming rate limiting for thin membranes. Membrane performances will be assessed in pilot loops in order to meet specific targets in terms of permeability and stability at temperature. A modelling study concerning the integration of the developed membranes in power and hydrogen production plants will be also performed. This will provide inputs for process scale-up and cost evaluation in the selected plant configurations in order to approach zero CO2 emission and a CO2 capture cost of 15 €/ton.",Dense membranes for efficient oxygen and hydrogen separation,FP7,31 July 2014,01 May 2010,3442696.0 DENDRIMAGE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Luminescence is an attractive strategy for a low cost, real-time and unambiguous detection of cancer cells and tumors due to its high sensitivity and the versatility of the instrumentation. The actual bottleneck is related to the imaging agents whose performances directly control the sensitivity and the selectivity of the real-time detection in living biological systems. Lanthanide luminescence offers several important advantages over organic fluorophores and semiconductor nanocrystals: (i) sharp emission bands for spectral discrimination from autofluorescence and multiplex detection, (ii) emission in the near-infrared, (iii) long luminescence lifetime for temporal discrimination, and (iv) strong resistance to photobleaching. The main idea of this proposal is to create and use new dendrimer lanthanide-based luminescent imaging agents to establish a novel modality of in vivo cancer cells and tumor detection. The proposed work includes the design of luminescent dendrimer complexes, the detailed investigation of their spectroscopic properties, as well as the in vivo tests at the cellular (microscopy) and small animals (macroscopy) levels to evaluate the performances of these imaging agents for practical applications. Proposed unique dendrimer technology is a versatile tool allowing (i) the enhancement of detection sensitivity since many lanthanide ions and lanthanide sensitizers can be combined within one discrete molecule increasing the number of photons per unit volume, (ii) the attachment of a broad variety of lanthanide sensitizers, including those allowing low energy excitation that is less harmful for biological systems, and (iii) the conjugation with a large variety of peptides for selective cancer cells and tumor targeting. Overall, successful completion of this project will result in creation of a novel lanthanide-based imaging methodology allowing real-time, selective and sensitive detection of different types of cancer tumors on the early stages.",Luminescent lanthanide dendrimer imaging agents for detection of cancer cells and tumors in vivo,FP7,30 April 2015,01 May 2013,194046.0 DENDRIMED,University of Lodz * Uniwersytet Łódzki,health,"The aim of the proposal is to enable the top-class young researcher from Belarus to work in a new promising branch of knowledge - on the edge of nanotechnology and medicine. It is planned that employment contract for two years will be established. The main idea of the project is studying the possibility to use dendrimers as new detoxication agents. This is an up-to-date issue due to the enhancement of chemical pollution in our environment that increases the risk of the intoxication. Dendrimers are large globular monodisperse polymers. As a result of their unique structure (many end groups on the surface and empty internal cavities) there are attempts to use them as drug carriers. The idea of using them as effective and specific detoxication agents is absolutely new. Toxins can be attached to end groups or incorporate inside the macromolecule. Estimation of dendrimers binding capacity and checking their influence on plasma proteins will be performed to construct detoxication dendrimers. The host institution represents a high scientific level and large training expertise, is the participant of well established international collaborations networks and is actively present in the dendrimer field from its very beginning. It offers also a rich programme of complementary training. The host institution is in a possession of modern, well-equipped labs with specialisedinstrumentation which respond the needs set by the project. The training in the host institution will be beneficial for fellowship applicant due to compatibility between the project and his research interests. His previous experience will be crucial for the implementation of the project. On the other hand, he will deepen his knowledge and increase his experience by acquaintance of new techniques. The project is within the framework of his coherent professional plans. He wants to continue the work after the returning to the mother institution. It ensures that the fellowship will give him a long-term benefit #",Application of dendrimers in medicine as new detoxication agents,FP6,31 October 2006,01 November 2004,182688.0 DENDRIMMUNEASSAYS,Andalusian Public Foundation for Health and Biomedicine Research in Malaga * Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud,health,"Nowadays drug allergy is considered a major public health problem in developed countries. Its correct diagnosis is very important for the adequate prescription of drugs to avoid risks for the patient. However, the adequate diagnosis is in certain cases difficult to address. This research aims at the development of sophisticated nanostructural materials with potential applications in drug allergy diagnosis. To this, the study will first focus on the identification of drug antigenic determinants still unknown by using different drug models as those derived from diclofenac and clavulanic acid, by a synthetic strategy to the hypothesized molecules and subsequent clinical evaluation. Secondly we propose the design of dendritic molecules displaying multiple presentations of relevant drug antigenic determinants. The determinants identified in the objective above and others already known as amoxicillin, will be coupled to the periphery of dendrimers and/or dendrons with the adequate methodology. The molecular recognition of these structures by specific IgE antibodies will be evaluated by radioimmunoassays, and performances in the structures will be carried out up to reach an optimal recognition. The final well-recognized structures will be anchored onto a solid phase with the aim of developing drug allergy diagnostic kits, to use in a routine clinical practice. Other approaches towards the study of the optimal distance in crosslink-IgE to produce the basophil activation will also be addressed in order to increase the sensitivity of this test. Biocompatible dendrimer as scaffolds, click chemistry methodologies, solid phases, organic chemical design will be used for the development of this project, with an important support of clinical evaluation and a biobank with patients sera. This methodology is expected to deliver a new tool box for the design of sophisticated nanostructural materials and versatile to the diagnosis of allergy to different drugs towards a microarray.",Development of sophisticated dendrimeric nanostructural materials with potential applications in drug allergy diagnosis: Towards immunoassays and cellular tests (basophil activation tests).,FP7,26 January 2015,01 September 2012,168896.0 DEROCA,Nanocyl SA,transport,"Currently, best flame retardant formulations are still often based on halogenated flame retardants (FR). Those halogneted FR are supsected to endcrine disrupters when leaching from the material and produce toxic fumes and acids (HBr, HCl, organoirritants, PCDD/Fs etc.).",Development of safe and eco-friendly flame retardant materials based on CNT co-additives for commodity polymers,FP7,11 June 2017,12 January 2012,0.0 DESHNAF,Euro-Consultants (2006) Ltd.,energy,"Super-hard materials films are useful in several sectors of the Industry: machine tools, engine parts, gas turbine blades, etc. They are needed wherever rapidly moving parts come into contact with hot, corrosive environment or when high friction is created. The most efficient way to make super-hard materials is by plasma activated techniques using CVD, PVD and mixtures of PACVD+PAPVD. It turns out that composite materials, which include a nano-structured phase, exhibit many desirable properties: hardness and wear resistance at high temperatures. However, this very new technology exhibits some problems which DESHNAF is proposed to help solve. Two families of super-hard materials are considered: one containing two hard phases (for example: nc-TiN and a-Si3N4): nc-MeN/a-Si3N4, a-TiSi; and one containing a hard phase and a soft phase, nc-MeN/Metal (Cu, Fe, Ni, etc.). The corresponding metal-carbides and metal-oxides are considered as well. The objective of this Coordination Action is to bring together researchers in order to discuss and clarify issues on the following topics: 1. Comparison of various plasma deposition techniques, 2. The influence of plasma and substrate variables on the resulting film, 3. Measurement of Super- hardness, 4. Thermal Stability and Oxidation Resistance, 5. Tribology, 6. Technology transfer DESNAF work-plan includes 8 work-packages. They include workshops on four of the themes of the project and one international symposium, the purpose of which will be the dissemination of results and technology transfer. International scientists will be invited to the workshops and to the conference. Other activities are the exchange of students and scientists, and two studies on specific subjects. The deliverables will include reports on the workshops, studies and exchange activities, relating to the problems posed by the project and their solutions. Another delivery is a book of abstracts of the internationa#",Deposition of super-hard nanocomposite films by plasma processing,FP6,31 December 2006,01 February 2004,779992.0 DESTINY,University of Bath,energy,"The DESTINY initial training network will tackle major challenges in the development of stable dye-sensitized solar cells, DSC. DSC offer exciting possibilities for applications in building integrated photovoltaics and consumer electronics. However they possess a complex structure with disparate materials. For DSC to be marketable and to compete with its inorganic counterparts, fundamental science has to be done to understand the causes of degradation and find ways of enhancing cell and module life time and stability without sacrificing performance and scalability. Ten internationally leading European research groups from six countries [including Dyesol UK, part of Europe's leading industrial supplier of DSC] have joined forces as full participants with a commercial associated partner, combining expertise in synthetic chemistry, spectroscopy, nanoscale physics and device engineering. Our highly integrated approach to understanding degradation causes and proposing solutions will take a major step towards the commercialization of DSC. This consortium is strongly committed to promote breakthroughs at the frontiers of science and engineering. The training dimension of DESTINY is reflected in the high priority we give to the training of early stage and experienced researchers, ESRs and ERs, through education and knowledge dissemination via Tutorial Courses, Annual Network Meetings, Training Schools, Conferences and Mobility Programmes. The network, with a strong focus on interdisciplinary training, builds on fruitful collaborations between the partners. Development of complementary skills (presentation, management, technology transfer, IP protection) will take place throughout the project lifetime. Interaction with stakeholders beyond those involved primarily in research will be maintained to enhance the international and societal dimension of our research and provide the wider community with information on this new technology.",DyE SensiTized solar cells wIth eNhanced stabilitY,FP7,31 October 2016,01 November 2012,3848961.0 DESYGN-IT,Trinity College Dublin,information and communications technology,"The global market for nanotubes (NTs) was worth ?1.4M in 2000, the potential market in 2007 is predicted to reach ?700M. Currently, there is no proven process to manufacture high quality NTs in bulk quantities. Other recognised barriers to industrial take-up include high NT costs (up to ?500/g) and a lack of feasible and affordable applications. The primary Scientific and Technical objective of DESYGN-IT is to establish Europe as the International Scientific Leader in the Design, Synthesis, Growth and Application of nanotubes, nanowires and arrays for industrial technology The project has relevance in applications across several sectors including electronics,mobile applications,diagnostics and high performance composites. DESYGN-IT involves 14 partners, from 6 countries, with complementary leading edge expertise in nanotube, nanowire and array expertise. 3 of the lead researchers have already spun out high-tech companies to exploit research outputs. 2 of the 4 high-tech SMEs partners are nanotech companies. The Technical Programme divides into 4 phases; the 1st is to synthesise a range of NTs and develop processes to scale-up the manufacturing technology. The 2nd phase is to surface engineer the tubes and fill them to form nanowires. In the 3rd phase NT arrays will be grown in a controlled fashion. The 4th and final phase focuses on the development of devices & materials for demonstration to industry and exploitation. DESYGN-IT will deliver -high quality NTs produced in a clean process for industrial use -NTs with defined diameter, chirality and electronic properties for high-tech applications -affordable arrays for device applications -added value products such as high strength materials, sensors to detect bacteria -metallic and semiconductor nanowires for future nanoelectronic applications A well placed European investment in DESYGN-IT will lead to substantial international scientific impact and the desired transformation of industry.","DEsign, SYnthesis and Growth of Nanotubes for Industrial Technology",FP6,31 January 2008,01 October 2004,3000000.0 DETECTHIV,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"We will develop a new platform and assay for the detection of HIV p24 antigen in serum or blood. The advantages of a p24 test are that it can detect HIV in an early stage of the infection, before antibodies develop, and that it is quantitative. The DETECTHIV project aims at developing an extremely simple viral load test with only one reactant (grafted colloids). In a first phase, a magnetic nanoparticles assay will be developed for use in a microtiter plate with as goal a detection limit of 1 ng/ml. In a second phase, the use of nanoparticles on a microfluidic chip will permit to detect p24 to levels as low as 0.1 picog/ml, one to two orders of magnitude more sensitive than classical Enzyme Linked Immuno-Sorbent Assay (ELISA) p24 tests. Validation of our platform will be both done with recombinant p24 samples and patient samples. The principle of our test consists in optically detecting the formation of a colloidal gel of magnetic nanoparticles (`agglutination test'). The gel forms in a magnetic field under the presence of antigens that are capable of linking irreversibly two colloidal particles. Therefore the latter are grafted with antibodies that are specific to the p24 antigen. An agglutination test requires only one step with only one reactant and the detection is achieved through simple optical absorbance measurements, owing to the strong optical scattering modification when passing from nanometric colloids to the gelled state. In the microfluidic chip test, a sample solution of serum or blood is transported through a suspension of magnetic nanoparticles that are magnetically suspended within a microfluidic channel. When brought into a magnetic field, the particles will be able to approach each other, form chains and will be irreversibly linked if the p24 antigen is present. Subsequently, on-chip light scattering techniques will be used to quantify the concentration of permanent chains or clustered beads, which is proportional to the antigen concentration.'",Sensitive nanoparticle assay for the detection of HIV,FP6,30 June 2010,01 January 2007,2026260.0 DEVICE,University of Oxford,health,"Applications of nanomaterials are based on concepts relying on the structural control of materials at the nanometre scale because at the nanometre scale properties denied to larger, bulk objects can be unlocked. However, technologies based on nanomaterials will only be successful if we are able to systematically control production processes and nanomaterials' morphologies. Hence, in the last 20 years much effort was dedicated towards understanding nanomaterials' formation and scaling-up production techniques from a laboratory to industrial scale. Yet, there are still many technical barriers preventing further progress in this area of research. These include the in-situ control of production processes employed for the generation of dedicated nanomaterials possessing tailored properties. We have followed a multidisciplinary approach of existing knowledge in nano-scale processing combined with state-of-the-art production techniques, and in-situ characterisation techniques, to create more efficient nanomaterials manufacturing techniques suitable for up-scaling. For this we have developed a prototype in-situ online control system which we have filed for a patent and aim to bring to market. With the ERC PoC we plan to carry out detailed analysis and develop a refined system suitable for an even wider range of industrial partners. Bringing such device together with an integrated approach will enable new applications of dedicated nanomaterials to be developed in the fields of energy saving and nano-composite materials in aerospace or medical applications.",Taking in-situ controlled nanomaterials manufacturing to market,FP7,28 February 2014,01 September 2012,147744.0 DFTPREDICTANDCHARCT,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),information and communications technology,"Magnetic materials play an important role in current information technology. The discovery that a {Mn12} cluster retains its magnetization in the absence of magnetic field may prove to be of immense technological importance. Among several possible applications, the most promising are high density data storage and quantum computation. The barrier for reorientation of magnetization in these ‘Single-Molecule Magnets’ (SMMs) is due to the presence of a large ground spin state and Ising-type anisotropy. During the last decade, synthetic chemists have been engaged in the synthesis of new SMMs with the aim to increase this barrier height. Several polynuclear transition metal complexes have been reported but the barrier height has not been raised beyond that observed for the original {Mn12} family of compounds. Therefore the synthesis of a new generation single molecule magnets with enhanced properties is still a major challenge. Denstiy functional theory (DFT) has emerged as new computational tool for the calculation of the electronic structure of large molecules. The key physical parameters (J, S, D and E) of large molecules can be reliably calculated using DFT. DFT methods have now reached a level where predictions can be made. The fundamental objective of the proposed project is to adopt a new approach for the synthesis of new generation materials whereby computational techniques will be extensively used for the prediction of magnetic properties. The synthesis of the predicted compounds will be carried out with the expertise knowledge of the host institute. The synthesised materials will be subjected to X-ray diffraction, magnetic measurements and EPR spectroscopy. This new approach will lead to the invention of new class materials possessing potential technological applications. In this respect the project is multidisciplinary encompassing computational chemistry, inorganic chemistry, physical chemistry, physics and materials science.",New generation magnetic materials - a synthetic methodology derived from computational predictions,FP6,22 August 2009,23 August 2007,144313.2 DIADEMS,Thales SA,health,"The DIADEMS project aims at exploiting the unique physical properties of NV color centres in ultrapure single-crystal CVD-grown diamond to develop innovative devices with unprecedented performances for ICT applications. By exploiting the atom-like structure of the NV that exhibits spin dependent optical transitions, DIADEMS will make optics-based magnetometry possible. The objectives of DIADEMS are to develop - Wide field magnetic imagers with 1 nT sensivities, - Scanning probe magnetometer with sensitivity 10 nT and spatial resolution 10 nm, - Sensor heads with resolution 1 pT. To reach such performances, DIADEMS will: - Use new theoretical protocols for sensing, - Develop ultrahigh purity diamond material with controlled single nitrogen implantation with a precision better than 5 nm, - Process scanning probe tips with diametre in the 20 nm range, - Transfer them to AFM cantilever, improve the emission properties of NV by coupling them with photonic cavities and photonic waveguides. DIADEMS outputs will demonstrate new ICT functionalities that will boost applications with high impact on society: - Calibration and optimization of write/read magnetic heads for future high capacity (3 Tbit per square inch) storage disk required for intense computing, - Imaging of electron-spin in graphene and carbon nanotubes for next generation of electronic components based on spintronics, - Non-invasive investigation of living neuronal networks to understand brain function, - Demonstration of magnetic resonance imaging of single spins allowing single protein imaging for medical research. DIADEMS aims at integrating the efforts of the European Community on NV centres to push further the limits of this promising technology and to keep Europe's prominent position.",DIAmond Devices Enabled Metrology and Sensing,FP7,31 August 2017,01 September 2013,5867000.0 DIAG-CANCER,Technion Israel Institute of Technology,health,"Cancer is rapidly becoming the greatest health hazard of our days. The most widespread cancers, are lung cancer (LC), breast cancer (BC), colorectal cancer (CC), and prostate cancer (PC). The impact of the various techniques used for diagnosis, screening and monitoring these cancers is either uncertain and/or inconvenient for the patients. This proposal aims to create a low-cost, easy-to-use and noninvasive screening method for LC, BC, CC, and PC based on breath testing with a novel nanosensors approach. With this in mind, we propose to: (a) modify an array of nanosensors based on Au nanoparticles for obtaining highly-sensitive detection levels of breath biomarkers of cancer; and (b) investigate the use of the developed array in a clinical study. Towards this end, we will collect suitable breath samples from patients and healthy controls in a clinical trial and test the feasibility of the device to detect LC, BC, CC, and PC, also in the presence of other diseases. We will then investigate possible ways to identify the stage of the disease, monitor the response to cancer treatment, and to identify cancer subtypes. Further, we propose that the device can be used for monitoring of cancer patients during and after treatment. The chemical nature of the cancer biomarkers will be identified through spectrometry techniques. The proposed approach would be used outside specialist settings and could considerably lessen the burden on the health budgets, both through the low cost of the proposed all-inclusive cancer test, and through earlier and, hence, more cost-effective cancer treatment.","Diagnosis, Screening and Monitoring of Cancer Diseases via Exhaled Breath Using an Array of Nanosensors",FP7,31 December 2014,01 January 2011,1200000.0 DIAMANT,University of Ulm * Universität Ulm,photonics,"The ability to engineer materials at the level of single atoms is rapidly becoming an urgent practical requirement as new technologies demand ever smaller devices. However, such a capability also offers profoundly new functionality for molecular-scale devices. The DIAMANT team has pioneered the discovery and development of diamond as a uniquely promising material system for solid-state molecular technologies: Diamond has exceptional optical and magnetic properties that are associated with dopant complexes — or 'solid-state molecules' — in the diamond lattice. The DIAMANT project will develop new technologies to enable placement of exactly one atom at a time into a selected location in the diamond lattice with nanometre precision. Control of magnetic and optical interactions between single dopants will enable engineering of artificial molecules with radically new functionalities. Applications in the fields of sensing and imaging at the nanoscale, novel data storage and information processing will be developed both theoretically and experimentally. The ability to control magnetic interactions on the atomic scale will enable miniaturisation of electronic devices down to the ultimate size limit — single molecules. We will manufacture photonic crystal cavities and plasmonic structures in diamond to realise the optical interfaces required for reading-in and reading-out information from these molecular-scale devices. Molecular sensors operating under ambient conditions promise to revolutionise the field of biological imaging and precision sensing. In the long term, determination the structure of single proteins will come within reach.",Diamond based atomic nanotechnologies,FP7,30 April 2014,01 January 2011,2810000.0 DIAMANTE,Process Systems Enterprise Ltd.,energy,"The proposed Transfer of Knowledge (ToK) industry-academia strategic partnership proposal aims at developing and applying a Transfer of Knowlege integrated approach for optimal material and process design of hydrogen storage systems using advanced materials, in a view of achieving an economic, safe and efficient storage operation. A well structured consortium including 2 universities and 2 SMEs will prompte a well strucured a transfer of knowledge research programme focusing on 3 main research areas (i) the development and characterisation of novel nano-composite metal hydride materials, (ii) the modelling, simulation and optimisation of metal hydride hydrogen storage beds including software development activities to assist material and process engineers/scientists to take rigorous and reliable decisions related to the design and operation of such systems, and (iii) pilot scale material development and process engineering/design . Exchange of research personnel between academic and SME parters, organisation of workshops, participation in conferences and other join activities will play a key role for the successful realization of the proposed project.",Development of Integrated Advanced Materials and Processes for Efficient Hydrogen Storage,FP6,28 February 2010,01 March 2006,1055414.11 DIAMEMS,Cardiff University,information and communications technology,"This project aims to develop high frequency, high quality factor micro and nano – electromechanical systems (MEMS) from nanocrystalline diamond (NCD). NCD offers superior performance to silicon for MEMS due to its extreme Young’s modulus, but it is also compatible with silicon CMOS technologies, offering a key advantage over other potential MEMS materials. High performance NCD growth and planarization will be optimised for MEMS applications. The realisation of continuous, smooth (<1nm rms over 1µm), pin hole free NCD over large areas exhibiting bulk diamond properties will enable a multitude of applications at drastically reduced cost to currently available bulk diamond technologies. The resulting material will have applications outside the MEMS field such as in tribology, optical coatings, electrochemical electrodes (when doped with boron), heat spreading etc. The development of clean room processing technologies of NCD will allow the fabrication of new devices and result in new ideas exploiting this novel material.",Microelectromechanical Systems from Nanocrystalline Diamond,FP7,03 July 2016,04 January 2012,270145.8 DIAMONDDNA,University of Oxford,health,"The superlative properties of diamond make it a choice material for making nanoscale devices over a broad range of applications. Diamond devices are conventionally made using 'top-down' processing following the seeding and growth of nanocrystalline diamond thin films, however, due to the great resilience of diamond, fabricating nanoscale devices is technologically demanding and nanoscale patterning requires expensive and lengthy processing such as electron beam lithography (EBL). Herein, the applicant presents a proposal to develop a novel, inexpensive, rapid and scalable methodology to fabricate nanoscale devices using 'bottom-up' processing with a feature resolution that will surpass current state-of-the-art processing techniques such as EBL. To achieve this goal, the technique of DNA Nanotechnology will be used to create self-assembled 2D DNA patterns of any desired shape, which will subsequently be electrostatically and covalently coated with nanodiamond and diamondoid particles. Following diamond seeding on DNA templates, the applicant proposes to grow nanocrystalline diamond thin film devices with nanoscale features. Given the diameter of DNA is ca. 2 nm, structures with nearly 2 nm feature resolution should be achievable, especially when seeding the structures with molecular diamondoid particles. Following development of said technique, nanoscale diamond devices (specifically nanophotonic structures, transistors and biosensors) will be fabricated that promise unprecedented performance.",DNA origami templates for nanocrystalline diamond nanostructures.,FP7,31 August 2016,01 September 2014,196456.0 DIANA,University of Helsinki * Helsingin Yliopisto,health,"This proposal combines the accumulated expertise from a previous FP5 EU project, Mechanisms of Proteinuria (QLG1-2000-00691) and an ongoing FP6 project, ADDNET (LSHB-CT-2003-503 364). We will utilize the latest knowledge on the pathophysiology of diabetic nephropathy and newly identified urinary markers of diabetic kidney damage to develop a predictive diagnostic test to follow disease progression. Biomarkers identified, in particular those preceding the development of diabetic kidney damage during the pre-microalbuminuric stage, will be evaluated in prospective clinical studies. By metabolomics we aim to find additional markers from diabetic urine, and will identify antibodies recognizing these metabolites/peptides from an antibody phage display-library. In parallel, two separate approaches will be used to develop diagnostic tests, one based on nanobead technology and the other on a multiplexing platform allowing combination of several measurables into a single test. Both technologies will utilize antibody capture methods. This will translate into early identification of patients at high risk of rapid loss of kidney function. The validation of the diagnostic tests emerges from the use of the largest European urine, serum and DNA databases of diabetic nephropathy with meticulously collected follow-up samples. Subsequent steps of the test development include premarketing evaluation and transfer of the test into patient use by an SME of diagnostic service provider in Finland. Another SME will provide market and competitor analyses and search for best market channels for the test in international markets. This approach directly aiming at developing a clinical urinary test will be supported by extensive basic research on the mechanisms/biomarkers of diabetic nephropathy at the level of the kidney. These include a novel method of in vivo biotinylation and state of the art proteomics on kidney samples during the development of experimental diabetic nephropathy.",Predictive diagnostics for diabetic nephropathy (DiaNa) - Novel nanotechnology based test platforms,FP6,30 November 2009,01 December 2006,2977400.0 DIASPORA,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,information and communications technology,"Phase-change materials are currently the most promising class of materials to be used as the next generation of memory. Their unique set of properties enables them to act as fast, reliable and durable, non-volatile memory. Research groups have demonstrated an excellent scaling behavior of phase-change memory and several large scale memory chips have been produced already demonstrating the outstanding potential of the technology.",Drift In Amorphous Semiconductors - A Partnership Of Rüschlikon and Aachen,FP7,08 July 2019,09 January 2013,0.0 DIAZOASSOCRICE,University of Vienna * Universität Wien,health,"Rice (Oryza sativa L.) is one of the world's most important crop plants. The production is strongly limited by nitrogen (N), which is typically supplied by industrial fertilizers that are costly and hazardous to the environment. Biological nitrogen fixation (BNF) through N2 fixing Bacteria and Archaea (diazotrophs) can alleviate the N-shortage in rice cultivation and was estimated to account for up to 25% of the total N-demand of the plants. However, our knowledge on N2 fixation related processes in the soil-microbe-plant interface of flooded rice fields (paddy soils) is still rudimentary. The proposed project seeks to increase the understanding of N2 fixation rates of diazotrophs and their respective contribution to the total BNF in these systems. A better understanding of the colonization patterns and preferential micro-niches of diazotroph associated with soil-grown rice roots is needed to unravel the interactions and N-transfer processes between diazotrophs and the rice plant on a biologically meaningful micro-scale. The objectives of the proposed research are: (1) to investigate the factors (soil types, rice genotypes, plant growth stages) influencing the community composition of diazotrophs associated with different soil/root micro-environments based on nifH amplicon sequencing; (2) the in situ analysis of spatial distribution and colonization patterns of native diazotrophs associated with soil-grown rice roots via fluorescence in situ hybridization (FISH); and (3) to assess the in situ activity of diazotrophs associated with soil-root micro-environments by 15N2 incubations and FISH-NanoSIMS. This project combines molecular methods, biogeochemical assays, and single-cell isotope analysis to analyze the in situ activities of diazotrophs in a previously unachievable manner. This multidisciplinary approach will be extremely powerful to address questions regarding the N2 fixation by plant-associated diazotrophs on a biologically relevant submicron scale.",Understanding the Micro-Environments of Diazotrophs and their Associated Activities in Rice,FP7,31 July 2016,01 August 2014,179137.0 DIB SCREENING,London School of Economics and Political Science,health,"Of the estimated 400 ion channels encoded in the human genome, ~70 are potassium (K+) channels. Their implication in a number of human diseases, e.g., cardiac arrhythmia, cystic fibrosis, makes K+ channels relevant drug targets. Whereas the number of high-resolution structures of membrane proteins has consistently increased over the last few years, their functional characterization using screening approaches has not kept pace with that of water-soluble proteins. In this context, reliable and informative rapid screening assays for membrane proteins are needed. By further developing the recently reported droplet interface bilayer (DIB) system, I intend to develop a rapid automatable platform for screening wild-type channels as well as libraries of mutant ion channels using Kcv (viral), KvAP (prokaryotic) and Kv1.2 (eukaryotic) as model systems. My blueprint for such a screening device is analogous to an assembly line consisting of a network of microchannels to; (i) construct lipid monolayer-encased aqueous droplets, (ii) synthesize ion channels inside these nanobioreactors by coupled in vitro transcription-translation (IVTT), (iii) form bilayers with other droplets containing channel blockers, (iv) subsequently measure single-channel conductance to determine activity. The assay will be capable of screening one channel against hundreds of blockers or screen a library of mutants against one or a few blockers. The development of this nanoscale-streamlined process offers the possibility of producing powerful lab-on-chip instruments for membrane protein assays, which have previously proven intractable.",Rapid functional characterization of ion channels with droplet interface bilayers,FP7,31 May 2012,01 June 2010,180783.0 DIBBIOPACK,AITIIP Technology Center * Fundación AITIIP,health,"The project aims on the one hand the development of new biobased materials specially adapted to the development of a wide range of containers or packages (films made by extrusion laminating, trays or lids developed by injection moulding and bottles performed through extrusion blow moulding technologies) and the improvement of thermal, mechanical and barrier properties of these packages through nanotechnology and innovative coatings. On the other hand, the project aims the operational integration of different intelligent technologies or smart devices to provide to the packaging value chain more information about the products and the processes, increase safety and quality of products through supply chain and improve the shelf-life of the packaged products. In both cases, the application of more flexible alternative processes and more environmentally sustainable and efficient technologies will be considered. The project includes the design, development, optimization and manufacturing of multifunctional smart packages, assuring compliance of environmental requirements through LCA and LCC analysis, managing nanotechnology risk through the whole packaging value chain, and finally, end user evaluation in different sectors as cosmetic, pharmaceutic and food industry. The project results and the high impact reached through a wide range of technologies utilized will boost the European Packaging Industry to a higher level.","DEVELOPMENT OF INJECTION AND BLOW EXTRUSION MOLDED BIODEGRADABLE AND MULTIFUNCTIONAL PACKAGES BY NANOTECHNOLOGY: IMPROVEMENT OF STRUCTURAL AND BARRIER PROPERTIES, SMART FEATURES AND SUSTAINABILITY",FP7,29 February 2016,01 March 2012,5702632.0 DIELECTRIC PV,Faculty of Sciences and Technology of the New University of Lisbon * Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa,energy,"A novel light trapping approach will be developed to enhance the absorption of thin film silicon (Si) solar cells using periodic arrangements of resonant dielectric micro-particles (DMPs) with dimensions on the other of the illuminating wavelengths. The main goal is to construct prototype cells that show enhanced sunlight-to-electricity conversion efficiency due to the action of DMP arrays incorporated on their transparent top contact. The strategy investigated here deals with advanced optical concepts that allow the manipulation and concentration of light in ways that can greatly surpass conventional geometrical optics or sub-wavelength plasmonics, by employing wavelength-sized dielectric scatterers. Therefore, the results of this work should not only broaden the understanding of the scientific community in the field of physical optics, but also foster the interest of the photovoltaics community towards light trapping with DMPs, a topic that is currently still under germination. The project will involve computational and experimental work executed in parallel in the Portuguese host institution CENIMAT-I3N, a world-renowned nanotechnology center in the area of functional materials. The computational studies will be performed using a finite-elements-method software (COMSOL) to optimize the physical parameters of the DMPs that allow maximum photocurrent enhancement in the Si cell material. The DMP structures will be then fabricated in laboratory using colloidal self-assembly combined with lithographic processes, and implemented in solar cells grown by plasmon-enhanced chemical vapor deposition. The work will be performed in close collaboration with the Italian institute IMM-CNR, a top microelectronics center where the candidate is currently working as a Marie Curie ITN Experienced Researcher. Therefore, the project shall nourish a new partnership between CENIMAT and IMM which is likely to be extended to other research and industrial partners in the European Union.",Advanced light trapping with dielectric micro-particle self-assembled arrays for low-cost and high-performance thin film solar cells,FP7,31 October 2016,01 November 2014,153330.0 DIESEL PM,Commission of the European Communities - Directorate General Joint Research Centre,transport,"Driven by concerns regarding global warming, air quality and human health, there is a clear trend toward increased sales of light-duty diesel vehicles in many parts of the world. This trend can result in many positive environmental benefits including low fuel consumption, and therefore low levels of CO2, CO, HC and volatile hydrocarbons. However, increased diesel sales have a downside, relatively high NOx and particulate emissions. As a result, countries around the world are increasingly tightening diesel regulations with the result that engine and reducing emissions technologies continues to advance, and reformulated diesel fuels continue to appear. In this context, the overall objective of this research project is to characterise physically and chemically particulate matter (PM) emissions from light-duty diesel vehicles and engines. The research pretends to assist in the setting of future regulation limits on PM emissions for this type of vehicles, addressing last generation diesel engines (direct injection), advanced particle emission reduction technologies (diesel particle filters) and novel diesel fuels (biodiesel). For that purpose, a new system for PM sampling and measurement will be developed and assessed in order to allow for accurate, repeatable and reproducible measurements of particles in the exhaust of diesel vehicles, mostly in the ultrafine and nanometer range, at the low emission levels from the technologies anticipated for the future market and at the stringency levels expected in future legislations. The project will be carried out in the vehicle and engine emissions laboratory (VELA) at the Institute for Environment and Sustainability (IES) of the Joint Research Centre (JRC) of the EU in Ispra (Italy). VELA has facilities to test emissions from engines and vehicles of all sizes, including a double dilution tunnel for measuring particles and gaseous ultra-low emissions (ULEV).",Physical and chemical characterisation of particle emissions from diesel driven vehicles,FP6,,,143746.0 DINAMIT,Charité - University Medicine Berlin * Charité - Universitätsmedizin Berlin,health,"Objectives of the joint exchange program 'DINaMiT' is to develop state-of-the art remotely responsive magnetic/metal nanoparticle functionalized drug delivery carriers for dual optical and magnetic resonance imaging modalities, equip such probes with theranostic detection/delivery capabilities and apply them for in-vivo study of anticancer drugs. To implement ambitious goals of such a program seven work-packages will be pursued. Each work-package will constitute of a necessary step for reaching the milestones and overall goals of the exchange programme. Functionalization of delivery carriers by nanoparticles is an important issue of successfully achieving the goals of the project. Optical imaging is the technique of choice for working with cell cultures and for routine fluorescent sample characterization. A significant advancement of the scientific research program is addition of magnetic response capabilities for such carriers, which results into dual optical / magnetically responsive system. Functionalized by nanoparticles, delivery carriers can be remotely activated based on the localized heating, which induces the permeability change of the carriers, but which does not affect the surrounding tissue. We envision using two-photon microscopy for deeper in-tissue reach. Magnetic functionality is viewed as a complementary approach which will allow even deeper reach. Magnetic resonance imaging (MRI) is a technique widely used for in-vivo diagnostic and tracking investigation. Polymeric and natural (red blood cells) delivery vehicles will be used for assembling ther-anostic carriers. Theranostic functionalities will be introduced by assembling the so-called multicompartment structures. Indeed, after such carriers are assembled and imaging/activation system is developed, in-vitro as well as in-vivo applications of such a system will be pursued. For in-vitro applications cell culture tests will be used, while that will be transferred for real in-vivo applications.",Dual-Imaging Nano/Micro-sized Theranostics (against cancer),FP7,31 July 2016,01 August 2013,265300.0 DINAMO,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,health,"Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular cell-biology with important applications to pharmacology. However fur further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniques that can operate with sufficient submicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes during the evolution steps of several types of frequently occurring cancers. This will create a novel tool studying the molecular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label-free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact, (2) of the kinetics of gene-assisted processes in the cells. Based on the development work of DINAMO, we propose to apply to apply luminescent and single spin detection techniques for real-time dynamic monitoring of biomolecular processes in cells.",DEVELOPMENT OF DIAMOND INTRACELLULAR NANOPROBES FOR ONCOGEN TRANSFORMATION DYNAMICS MONITORING IN LIVING CELLS,FP7,30 April 2013,01 May 2010,2787892.0 DIREKT,Uppsala University * Uppsala Universitet,health,"Chronic kidney disease is world wide a major cause of end-stage renal disease (ESRD). 800.000 patients in Europe and in the US, respectively, require long-term treatment initially with peritoneal dialysis, followed by hemodialysis and kidney transplantation. Each ESRD patient on hemodialysis costs ≈€40000 to €80000 per year, has extremely poor quality of life and an average life expectancy of only 4 years. Kidney transplantation totally changes life for an ESRD patient who can then return to normal life, but this treatment is hampered by the low number of available kidney grafts. All these treatments are, however, associated with severe adverse reactions that cause damaging thromboinflammation, triggered by the intravascular innate immune system, which lead to poor results and non-function. The overall aim of this project is to clarify the mechanisms and identify nature´s own specific control points of regulation in these adverse reactions in order to be able to significantly improve the quality of hemodialysis devices and kidney grafts by applying these concepts of regulation in hemodialysis and kidney transplantation. We envisage that conveying a novel soluble complement inhibitor to the clinical stage via phase 1/2a clinical studies, creation of nano-profiled surfaces with low activating properties and generation of easy-to-apply one step-coatings for treatment of biomaterials (hemodialysis) and endothelial cell surfaces (kidney grafts) will revolutionize the treatment modalities of ESRD. The feasible hemodialysis treatment periods are anticipated to be extended, combined with an improved quality of life and in kidney transplantation attenuation of innate immune reactions will prolong the life expectancy of the graft and make kidneys more accessible for transplantation. All the novel techniques can be applied to other types of implantations, extracorporeal treatments and transplantation and in the future be used in xenotransplantation and stem cell therapies.",Disarming the intravascular innate immune response to improve treatment modalities for chronic kidney disease,FP7,30 November 2017,01 December 2013,5984070.0 DISCANT,Aston University,photonics,"The proposed research program aims at knowledge transfer from a Fellow with strong expertise in mode-locking fibre lasers using carbon nanotubes to the EU host who can combine this knowledge with own expertise in soliton theory and dispersion management for advancing the fast growing field of fibre lasers. The overall research objective is to develop new concepts, techniques and approaches to the new design of high-energy fibre lasers based on a transfer of the methods of nonlinear science into the field of optical engineering. The proposed interdisciplinary project will link optical engineering laser research to applied mathematics, nonlinear wave physics and nano-material physics. The academic profile of the applicant ideally matches the proposed research project. Dr. Webb as a host will supervise the experimental research in the project and Prof. Turitsyn as a co-supervisor will coordinate theoretical studies on dispersion-managed dissipative soliton fibre lasers. The project is split into four distinct work packages (WPs) targeting four types of research goals and corresponding knowledge transfer. • WP1 targets fundamental properties of fibre laser systems. • WP2 will create a platform for fabrication of carbon nanotube saturable absorbers for photonic applications. • WP3 will focus on demonstration of advanced practical high-energy fibre laser systems. • WP4 will aim to optimize noise performance of the laser systems and broaden their operating wavelength range. The proposed interdisciplinary program will make important contributions both to science and technology and European excellence and competitiveness, namely, the project: • will enhance EU research in laser science, optical communications and nonlinear photonics; • will establish an internationally leading position for EU in the science, application and production technologies of fibre lasers; • will lead to a new level of high-brilliance laser sources important for a range of applications.",High-energy dissipative soliton dispersion-managed fibre laser based on carbon nanotubes,FP7,17 April 2015,18 April 2013,209033.0 DISCOGNOSIS,Albert Ludwigs University of Freiburg * Albert-Ludwigs-Universität Freiburg,health,"The project aims to develop a fully integrated, automated and user-friendly platform for infectious disease diagnosis. Malaria can be treated in just 48 hours, but delayed or false diagnosis or missing a relevant alternative cause of fever may be lethal. Therefore, other diseases with similar clinical symptoms will be investigated too. DiscoGnosis will integrate micro, nano, and bio components into a multi-functional point-of-care platform, performing simultaneously protein and genetic analysis to timely and accurately identify major pathogenic causes of fever, enabling proper treatment. A foil-based centrifugal microfluidic lab-on-a-chip cartridge, core of the platform, will integrate monolithically all necessary unit operations for raw sample treatment (blood-to-result regime), from sample collection and injection, to plasma separation, DNA extraction and purification. Low-cost production, scalable from prototype to batch fabrication (with proper quality control, calibration and standards specifications) will render the platform affordable to end users, even in developing countries; high sensitivity detection and multiplexity will rely on magnetic microparticles and quantum dot technologies, supported by dedicated optics development; rapid analysis (~30 min) will be achieved via isothermal DNA amplification protocols. The entire system will be validated in a controlled field test with standardized samples and by end-users in high-risk developing countries through partners' established contacts. Data management will be implemented to allow rational organization in the field and to reinforce the 'shield' of Europe against such diseases, as more than 30, 000 malaria cases are reported annually among returning European tourists. This generic point-of-care platform can be applied to many diseases (eg, cancer, cardiovascular, Alzheimer) by only changing its bio-components. The strong SME participation indicates the high commercialization potential of the project.",Disc-shaped point-of-care platform for infectious disease diagnosis,FP7,31 October 2015,01 November 2012,2922000.0 DISCOVERTABLE,University of Kent,information and communications technology,"In DiscoverTable, Wang (the local host) and Chua (the fellow) will further extend their advocated tables to cover not only the “ideal” elements but also non-ideal elements with additional state variables, which will reflect the latest advance in modern information technology (IT) because most of real-world molecular and nano-electronic elements have multiple state variables. The importance of a circuit element table is similar to that of Mendeleev’s Periodic Table of Chemical Elements in Chemistry. Such a table would help us categorise the existing circuit elements and predict new circuit elements.",Re-discovering a Periodic Table of Elementary Circuit Elements,FP7,07 July 2017,08 January 2013,309235.2 DIVA,University of Basel * Universität Basel,health,"Avidins are amongst the most widely used proteins in biotechnology, with applications encompassing molecular labelling, purification & detection, as well as uses in diagnostics, targeted drug delivery and nanotechnology, such as enantioselective catalysis by artificial catalysts. Avidins also serve as outstanding model systems for our understanding of biomolecular interactions, through their extremely high affinity for biotin (dissociation constant, Kd≈10−14–10−16 M).and biotinylated molecules. However, despite their importance in biotechnology, only two avidins have found widespread and routine use amongst the scientific community: chicken avidin and bacterial streptavidin. DIVA aims to exploit the recent identification of novel avidins in DNA sequence databases to generate novel variants of these proteins. DIVA will also use protein engineering to provide further genetic diversity, such as defined asymmetric tetramers of avidins consisting of different subunits. The overall aim is to expand the range of avidins available to biotechnologists and to increase their use and potential applications.",Genetic DIversity of AVIdins for Novel Biotech Applications,FP7,30 September 2011,01 October 2008,45000.0 DIVAN,Imperial College London,information and communications technology,"The objective of DIVAN is to develop a robust, potentially industrially viable process for the discrete assembly of individual Carbon Nano Tubes (CNTs). This competence allows realising devices and applications in which individual CNTs are integrated with micro-scale structures, to provide unique performance or new functions. Applications can be found in sensors, scientific instruments, and a wide variety of nanoelectronic devices like switches. A CNT is a cylindrically shaped nanostructure composed of carbon hexagons. CNTs are grown on a substrate in large numbers using a chemical process. Currently there is no viable method to volume assembly of discrete CNTs. DIVAN aims to rationalise the nano-scale assembly process by developing a set of linkable basic assembly operations. Basic operations include sorting, characterisation, handling and placement of CNTs. The basic assembly operations can be linked together to form complete assembly process chains for bringing CNTs from their fabricated state to their assembled and interconnected state. An essential contribution of the project to the field is the development of an assembly theory for nano-scale assembly. This assembly theory defines the boundary conditions for the assembly operations to be developed, and provides the backbone for structured design and evaluation of nano-scale assembly processes for specific cases. In this way, a systematic engineering and production perspective is added to the predominantly fundamental research oriented field of nanotechnology. Innovative principles for implementing the basic operations will be investigated, including the use of micro-fluidic devices to dispense CNTs, and the use of micro-scale handling structures. A benchmark device, a NEMS accelerometer, will be realised to evaluate and demonstrate the developed processes. An essential criterion is that the assembly processes have to be compatible with microfabrication processes to ensure volume upscalability.",Discrete Volume Assembly at Nano-Scale,FP7,11 June 2013,12 January 2010,120394.8 DIVINOCELL,Consejo Superior De Investigaciones Científicas (CSIC),health,"The DIVINOCELL project will identify novel Gram-negative targets by exploiting the components of the divisome, their activities and interactions. It will also design selective assays for screening and will obtain a new class of antimicrobials: compounds to block bacterial division. New medicines to attack Gram-negative pathogens will decrease the burden of infectious disease and have a highly beneficial social and economic impact in Europe and beyond. Cell division is an essential and still underexploited process with excellent properties to yield new inhibitors to attack infection by blocking the proliferation of pathogens. Inhibitors directed against bacterial division targets, that are not present in eukaryotic cells, will be both effective and innocuous to humans and animals. In addition, as many of their structures will be based on interaction domains and synthetic scaffolds, they will generate resistance at levels lower than the present antibiotics. DIVINOCELL will apply existing and new knowledge on the molecular biology of Gram-negative cell division as well as novel analytical (nanodiscs), bioinformatic (molecular dynamics), structural (membrane protein crystals) and imaging (lanthanide staining) tools to exploit in the test tube the structures and interactions of targets in the divisome and the septum. DIVINOCELL will develop potent systematic screening assays and will use them to select compounds specifically tailored to inhibit the division of Gram-negatives (not precluding broad spectrum ones). Secondary activity and cell assays, based on the properties of bacterial division, will be generated to validate hits and advance them to leads. The medicinal properties of selected leads will be improved. The translational steps of the project will be developed by 4 SMEs in close collaboration with the 8 academic partners having well-proven expertise in molecular microbiology, protein chemistry, structural biology, biophysics, imaging and bioinformatics.",Exploiting Gram-negative cell division targets in the test tube to obtain anti-microbial compounds,FP7,31 August 2013,01 March 2009,5956086.0 DMH,Trinity College Dublin,health,"The subject of the project is the magnetodynamics of single-domain ferromagnetic nanoparticles driven by strong ac magnetic fields. The phenomenon of prime interest here is dynamic magnetic hysteresis (DMH) . The main important applications of DMH are (i) magnetic moment switching (under pulsed fields) in magnetic data storage and (ii) heat generation in magnetically induced hyperthermia (medical as well as other applications). Nowdays local magnetic hyperthermia is one of the most promising approaches in addition to chemical and radiological methods for cancer treatment. Unfortunately, the progress is hampered by the lack of reliable understanding of the laws governing the interplay between internal (magnetic relaxation) and external (viscous dissipation due to mechanical rotation) losses and their joint effect on heat generation. There also exists a 'no-man land' between two limiting frameworks: (i) natural (intrinsic) magnetic resonance where the magnetic moment precession is due to the internal field and (ii) the standard (Zeeman) magnetic resonance where the main factor in the precession is dominated by a strong external field while the internal field is merely a perturbation. In the second case, substantial increase in the absorption can be achieved which is important for hyperthermia. We are going to study magnetodynamics and energy absorption in solid and liquid suspensions of magnetic nanoparticles by developing analytical and numerical techniques for treating effects of dissipation to the surrounding heat bath in DMH. The results obtained from analytical and numerical solutions of the Gilbert-Landau-LIfshitz equation augmented by a random field term will be compared with available experimental observations.",Nonlinear dynamic hysteresis of nanomagnetic particles with application to data storage and medical hyperthermia,FP7,31 March 2015,01 April 2012,47500.0 DNA MACHINES,University of Bonn* Rheinische Friedrich-Wilhelms-Universität Bonn,health,"DNA-nanotechnology has created different topologies, including replicable ones, nanomachines, patterns, logic gates, or algorithmic assemblies. Interlocked double-stranded (ds) DNA-architectures like catenanes or rotaxanes, wherein individual components can be set in motion in a controlled manner have not been accessible. These molecules represent long-sought devices for nanorobotics and nanomechanics because they possess a unique mechanical bonding motif, not available to conventional building blocks. The project will apply an unprecedented, simple, and modular interlocking paradigm for double-stranded (ds) circular DNA geometries that we have developed in preliminary studies. This will now be taken several crucial steps forward by generating unconventional DNA-, protein-, aptamer-, and ribozyme hybrid architectures containing interlocked structures wherein the motion of individual components can be controlled in many different ways. We will design, construct, and evaluate switchable autonomous DNA-nanomachines that function as rotational motors, muscles, or switches for powering and manipulating nanoscale components. The DNA machines envisaged in this project will be applied, for example, in synthetic supramolecular self-assembly systems that emulate complex biological machines like motor proteins, nucleic acid polymerases, or ATPases. In addition, they will be developed for multiple purposes in biosensing, logic-gate- and memory circuit assembly, and catalysis. This efficient method for constructing interlocked dsDNA nanostructures opens the exciting possibility of conjoining the area of lifesciences with that of nanomechanical engineering, paving entirely new avenues for nanotechnology. The project is highly interdisciplinary and will open a new field with enormous innovative potential and implications ranging from chemistry to synthetic biology, and from the life sciences to nano-engineering.",Nanomachines based on interlocked DNA architectures,FP7,29 February 2016,01 March 2011,2499522.0 DNA NANO-ROUTERS,Bar-Ilan University,health,"Almost every aspect of higher organism biology such as metabolism, growth and immunity, is regulated by intricate communication networks between multiple cell types. The ability to skew or interfere with these networks could lead to new ways to alleviate diseases caused or maintained by the interacting cells. However, since these cells are often dispersed across the entire organism, precise modulation of a single communication line is very challenging. In this project I propose to achieve this goal by DNA origami nanorobots programmed as routing devices for cell-cell communication. Each nanorobot is programmed to collect and sequester a specific type of signal molecule (cytokine, hormone etc.), and deliver it exclusively to a specific type of cell. Once programmed, a large group of nanorobots (~1016) effectively controls the traffic of signal molecules within an entire network, rendering it susceptible to arbitrary manipulations. These include re-routing signals to different cell addresses, up- or down-tuning the traffic volume in the path, or preventing a specific cell type from transmitting and receiving signals. This technology presents an advanced working draft towards automated biology as a strategy to solve challenges such as food, sustainable energy, emerging diseases etc.",Logical re-routing of cellular communication networks by DNA origami nanorobot,FP7,30 November 2017,01 December 2013,100000.0 DNA NANOELECTRONICS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"We propose to study electrical transport in two types of one-dimensional DNA-metal hybrid systems: (a) DNA modified gold nanoparticles pearl chains, and (b) DNA templated metal nanowires. We will analyze systems type (a) in two steps. First, we will study the transport through very short thiol functionalized single DNA molecules using the mechanically controllable break junction (MCBJ) technique. This method allows obtaining electrodes where their separation is controlled with sub atomic precision. In this step, we will give an emphasis to the following issue: What is the conductance of various short DNA molecules, and is it sequence dependent? This information we will use in the next step to engineer gold colloids-DNA chains. We will study the chains in three-terminal (transistor) geometry. In parallel we will fabricate systems type (b) from different metals, of various lengths and diameters. We will analyze the transport through these systems in detail by attaching them directly to metallic electrodes. A synergetic influence of chemical and physical properties of nanowires on charge transport, will be studied in order to obtain systematic characterization.",DNA Based Nanoelectronics,FP6,09 October 2008,10 October 2006,158218.0 DNA-AMP,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"Bulky DNA adducts formed from chemical carcinogens dictate structure, reactivity, and mechanism of chemical-biological reactions; therefore, their identification is central to evaluating and mitigating cancer risk. Natural food components, or others associated with certain food preparations or metabolic conversions, initiate potentially damaging genetic mutations after forming DNA adducts, which contribute critically to carcinogenesis, despite the fact that they are typically repaired biochemically and they are formed at extremely low levels. This situation places significant limitations on our ability to understand the role of formation, repair, and mutagenesis on the basis of the complex DNA reactivity profiles of food components. The long-term goals of this research are to contribute basic knowledge and advanced experimental tools required to understand, on the basis of chemical structure, the contributions of chronic, potentially adverse, dietary chemical carcinogen exposure to cancer development. It is proposed that a new class of synthetic nucleosides, devised on the basis of preliminary discoveries made in the independent laboratory of the applicant, will serve as molecular probes for bulky DNA adducts and can be effectively used to study and AMPlify, i.e. as a sensitive diagnostic tool, low levels of chemically-specific modes of DNA damage. The proposed research is a chemical biology-based approach to the study of carcinogenesis. Experiments involve chemical synthesis, thermodynamic and kinetic characterization DNA-DNA and enzyme-DNA interactions, and nanoparticle-based molecular probes. The proposal describes a potentially ground-breaking approach for profiling the biological reactivities of chemical carcinogens, and we expect to gain fundamental knowledge and chemical tools that can contribute to the prevention of diseases influenced by gene-environment interactions.",DNA Adduct Molecular Probes: Elucidating the Diet-Cancer Connection at Chemical Resolution,FP7,31 August 2015,01 September 2010,1500000.0 DNA-DAR,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The proposed project will develop a polymer-based optofluidic lab-on-a-chip device to study the physical dynamics of label-free DNA molecules. DNA contains the complete genetic code of an organism, yet it is the interaction of DNA with other molecular species that determine how that code is interpreted. Moreover, it has been suggested that there are other factors beyond the genomic sequence that are involved in an organism's complexity. Subsequently, this project will study the physical dynamics of DNA by spatially profiling its restriction and extension attributes as it propagates along integrated nanochannels. The operating principle of the device will be based on the refractive index (RI) perturbation caused by a DNA molecule as it passes through an optical detector region. The optical detection scheme will use band-edge lasers in photonic crystals to monitor subtle shifts in wavelength caused by the change in RI. This will result in a label-free approach to characterise DNA, circumventing the negative effects of dye staining -a common DNA investigation technique -that prevents true measurements of the molecule's behaviour. The device material will be polymer-based, offering an affordable development trajectory via nanoimprint technology. In addition, polymer is a suitable material for introducing active dopants, such as fluorescent dyes, to generate the photonic crystal band-edge laser components. Finally, the integration of nanochannels to the devices offers several novel advantages: the nanochannel provides a straightforward approach to deliver DNA to the detector regions; the nanochannel confines DNA, causing an extension of its molecular conformation and allowing access to structural detail otherwise difficult to obtain; and the nanochannel dimensions provide an opportunity to form slot waveguides, a mechanism that drastically increases optical mode intensities within narrow channels to significantly improve detection sensitivity.",DNA sensor in polymer photonic crystal band-edge lasers with integrated nanochannels,FP7,31 October 2012,01 November 2010,207629.0 DNA-NANODEVICES,Tel Aviv University,information and communications technology,"DNA is a fascinating soft material that naturally expresses two of the three main features required from molecular nanoelectronic components, namely recognition and specific structuring (sequence, length). The third additional property that is needed in order to implement DNA-derivatives for electrical device applications is conductivity, still quite disputable in native-DNA. The proposing team recently developed novel DNA-based nanowires, evolved from modifications of the native double helix, that show encouraging conductivity signals while preserving the structuring and recognition qualities. We now plan to proceed to the more ambitious goal of realizing DNA-based nanodevices on the ground of the disclosed nanowires, by maturing to a full control over the molecular structure and electric response. Our strategy is to use specific alterations of the sequence and inclusions of hybrid inorganic elements to pre-planned locations in the wire. A device resulting from this approach will be nanometric in size and embedded in the wire itself. We expect to realize a device-wire with a controlled non-linear response (bi-stability or negative differential resistance) in the end of the project. The envisaged devices enclose the seeds to bloom into self-assembled hybrid nano-sized computational networks, connected to the outside world (e.g., metal electrodes) through DNA recognition, and providing rich truth tables on a tiny scale: these are among the top-ranked objectives of the IST program. The high risk implicit in advancing a new multidisciplinary concept for hybrid nanoelectronics with DNA hetero-polymers is compensated by the huge technological potential of the eventual products, and by the recognized scientific excellence of the proposing team, particularly on the basis of its already existing achievemnts. The success of the project should be measured in terms of generated cutting edge knowledge, and foundations for long-term industrial impact.",DNA-based Nanoelectronic Devices,FP6,30 September 2010,30 April 2006,1850000.0 DNA-TRAP,Procarta Biosystems Ltd.,health,"Antimicrobial agents, such as antibiotics, have dramatically reduced the number of deaths from infectious diseases over the last 70 years. However, through overuse and misuse of these agents, many micro-organisms have developed antimicrobial resistance. Oligonucleotide therapeutics have the potential to become the new class of antibacterials capable of treating a broad range of infections. By acting on novel targets, they circumvent current resistance mechanisms and with judicious use, can suppress the rise of future resistance. DNA-TRAP will build on a platform technology that uses proprietary nucleic acid-based Transcription Factor Decoys (TFDs) that act on novel genomic targets by capturing key regulatory proteins to block essential bacterial genes and defeat infection. Taking forward newly emerging insights and expertise that exists within each of the partners and through the mutual secondment of researchers, the project aims to develop a new class of nanoparticulate antibacterials capable of meeting the clinical challenge of drug-resistant infections such as Clostridium difficile and Pseudomonas aeruginosa. DNA-TRAP will establish a lasting, international partnership for transfer of knowledge between Industry and Academia in the field of nanomedicine. Exchange of knowledge and expertise between the partners is key to establishing the fundamental properties of nanostructured drug delivery systems to treat bacterial infections and through this, provide the basis for building a manufacturing platform to advance the experimental therapeutic into clinical trials. 17 researchers in the field of drug development and delivery from 2 commercial (SME) and 2 non-commercial partners across 2 member states, will have the opportunity to share and acquire new complementary and multidisciplinary knowledge, through inter-sectoral and interdisciplinary exchange, allowing for the development of new solutions and the establishment of further joint research projects.",DNA-TRAP -Delivery of Nucleic Acid-Based Therapeutics for the TReatment of Antibiotic-Resistant Pathogens,FP7,30 September 2017,01 October 2013,2371031.0 DNALIGHTMAP,Tel Aviv University,health,"This proposal seeks to utilize single molecule optical detection to directly visualize and analyze genome structural and copy number variation (SVs & CNVs) spanning up to hundreds kb of native chromosomal DNA . The project focuses on a pathogenic macro satellite repeat in the subtelomere of chromosome 4q that is linked to the third most common inherited muscular dystrophy, Facioscapulohumeral muscular dystrophy (FSHD). Specific sequences on subtelomeres are labeled with fluorescent molecules via enzymatic reactions to create a unique, chromosome specific fluorescence pattern. The DNA is then stretched in thousands of parallel nanochannels by electrophoresis and imaged on a fluorescence microscope. The resulting patterns along the DNA backbone are compared to a reference map computed from the known genome sequence and variations from the reference are classified and characterized. Specifically, we will be able to count the exact number of repeat blocks in pathogenic vs. non-pathogenic chromosomes. The immediate outcome of this project is a powerful diagnostic tool for FSHD and a proof of principle for single molecule, high throughput structural variation analysis on a genomic scale.",Mapping structural variation on native chromosomal DNA -a single molecule approach,FP7,31 August 2016,01 September 2012,100000.0 DNAMAP,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The objective of this project is to investigate nanofluidic single-molecule approaches to DNA mapping using a new denaturation mapping concept developed by W. Reisner. We propose to make advances in extending these approaches to true genome scale applications. We will furthermore demonstrate that epigenomic as well as genomic variations can be mapped with these approaches. Eventually, we seek to develop a device for mapping DNA that was extracted from single-cells on-chip. At the first stage of the project, the fellow will work with Prof. Reisner (McGill Univ.), who is a leader in nanofluidics for DNA analysis, and who will enable basic advances towards genome-scale and epigenetic mapping applications. Here, the fellow will study DNA mapping techniques and will learn how to design and fabricate nanofluidic devices for that purpose. Nanofabrication encompasses highly specialised tools and techniques which the fellow requires throughout the project. At the second stage, the fellow will be hosted by Prof. A. Kristensen (Techn. Univ. of Denmark) who is an expert in nanoimprinting and microfluidics. He will enable advances towards implementing inexpensive fabrication processes with integrated microfluidics for single-cell lysis and DNA purification. The fellow will therefore learn fabrication of polymer-based devices which can be mass-produced inexpensively by injection molding and nanoimprinting. Furthermore, the fellow will learn how to operate the fabricated on-chip devices with integrated single-cell lysis and DNA purification, and subsequent DNA mapping. The broad range of competencies the fellow will acquire throughout the project will help him establish an independent career in micro/nanofluidics. The proposed advances will contribute to technologies that can (1) speed-up large-scale genome assembly (2) analyse epigenomes/genomes from large ensembles of cells and (3) do so in an inexpensive format that can be widely distributed to potential biomedical end-users.",Nanofluidic Methods for Mapping Epigenetic and Genomic Variation,FP7,31 August 2014,01 September 2011,243467.0 DNAMECHSEQ,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The DNA molecule encodes the genetic information; reading the sequence it carries is of great relevance for biology and medicine. Currently available techniques are able to sequence DNA with high reliability but are very expensive in terms of time and human resources. We will focus on a new method for sequencing that is under intensive experimental investigation. The double helix of the DNA molecule is opened through a mechanical separation of the two strands, and the required force is measured. From the force signal one would like to reconstruct the DNA sequence. The method is fast, but the force signal is very noisy and the reconstruction of the sequence turns out to be a difficult inference problem. A detailed comprehension of the noise and the design of optimal algorithms for data analysis is mandatory to achieve a reliable sequencing. The project will focus on the theoretical aspects of the method. We will: 1) investigate the different sources of noise in the context of recent models for the DNA opening; 2) try to obtain theoretical bounds on the amount of information that can be obtained from the mechanical opening experiment as a function of the experimental parameters (resolution, total duration of the experiment, ...); 3) design efficient algorithms to optimize the data analysis in order to get as close as possible to the theoretical bounds; 4) test the algorithms against experimental data on known sequences and attempt to predict unknown sequences. The project, if successful, will clearly establish the intrinsic limits of the method, in terms of information theory. Our results will be validated through a close collaboration with a leading experimental group in the field and, hopefully, will allow for a reliable mechanical sequencing in a not too far future. We believe that the project will enhance the EU competitivity in the thematic priorities 3 (nanosciences) and 1 (genomics) of the FP6.",Sequencing DNA molecules from mechanical opening experiments: bounds from information theory and inference algorithms,FP6,30 September 2009,01 October 2007,143433.0 DNAMETRY,Technical University Dresden * Technische Universität Dresden,health,"DNA metabolism is governed by a delicate balance between compacting the stored genetic information while simultaneously ensuring a highly dynamically access to it. This interdisciplinary project aims (i) to understand the mechanics and dynamics of chromatin as well as the mechanism of enzymes involved in DNA metabolism on a molecular level and (ii) to develop new nanometric tools based on optical methods and 3D DNA nanostructures that allow addressing new experimental questions. Within the research project novel nanoscopic detection assays based on the combination of magnetic tweezers and optical methods shall be developed, such as ultra-fast torque spectroscopy and combined FRET-force spectroscopy. Our single-molecule assays shall be applied to study the material properties of self-assembled 3D DNA nanostructures, which shall then be used to set up improved high resolution single-molecule assays. These technological improvements will become key to obtain insight into structure and dynamics of in vitro reconstituted chromatin as response to external mechanical stress but also into the operation of molecular motors that themselves generate forces and torques on DNA and chromatin. The main goal of the project is to use nanotechnological tools to understand design principles of biomolecules, biomaterials and biological motors, which in turn shall be used to develop smarter nanotools and functional elements.",DNA based nanometry: Exploring chromatin structure and molecular motors,FP7,31 December 2015,01 January 2011,1500000.0 DODECIN,University of Siegen * Universität Siegen,energy,"The flavoprotein dodecin from the halophilic organism Halobacterium salinarum binds not only native but also artificial flavins with high affinities in their oxidized state. Reduction of the flavins induces the dissociation of the holocomplex into apododecin and free flavin. Based on these unique binding characteristics, a molecular crane shall be developed that is able to pick up and to release molecular objects through a switch of the electric potential. For this purpose, a single flavin has to be linked to the conductive tip of an atomic force microscope via a molecular wire-like subunit (flavin molecular wire AFM tip/electrode). On the basis of such an electrochemically switchable molecular crane, it will be possible to bind and release single molecules of dodecin apoprotein or even larger molecular assemblies attached to apododecin serving as molecular junction. While the construction of a molecular crane for the transport of single molecules is the main goal, the successful realization of this project fundamentally depends on the synthesis and characterization of molecular wire-like subunits, which can be used to attach redox-active proteins to surfaces in an electrochemically switchable state. Thus, functionalized single-walled carbon nanotubes or organic p-electron systems will be examined with respect to their ability to serve as molecular wire. Surface modification protocols have to be developed and modified surfaces will be investigated by a combination of atomic force microscopy, surface plasmon resonance spectroscopy, and electrochemical methods. The results of these studies will be of general interest for the construction of molecular switches, devices, and transport systems, and for the development of amperometric biosensors and biofuel cells.",Construction of a Molecular Crane Based on the Flavoprotein Dodecin,FP7,31 October 2015,01 November 2009,1100000.0 DOMINO,University of Montpellier 2 Sciences et Techniques * Université Montpellier 2 Sciences et Techniques,photonics,"The 3 - 5 �m window of the mid-IR wavelength range is the window of choice for developing photonic-based products with important societal impact such as photonic sensors for environment monitoring, photonic diagnosis devices for health care, laser assisted surgery, free-space optical communication systems. However, there is actually a lack of suitable laser diodes (LDs) operating in this domain.The main objective of this project is to demonstrate the feasibility of antimonides-based quantum-dots (QDs) nano-photonic quantum-dots laser diodes (QDLDs) operating continuous wave (cw) at room temperature (RT) in the 3-5 �m wavelength range. Sb-based heterostructures, grown on GaSb or InAs substrates, exhibit a number of unique possibilities among III-V compounds in terms of band structure engineering. In particular, it is the only III-V technology exhibiting interband transitions in the mid-IR. However till now no quantum-well laser diode is able to operate cw at RT at wavelengths between 3 and 5 �m. QDs heterostructures are expected to extend the emitted wavelength and to strongly improve the performances of semiconductor LDs (reduced threshold, high operating temperature) as demonstrated with the GaAs and InP technologies. The successful demonstration of Sb-based QDLDs could thus pave the way to the development of high performance mid-IR optoelectronic devices and photonic sensors. However, the properties of Sb-based nanostructures remain unknown up to now. Another goal of our project will be to retrieve a clear picture of their basic physical (structural, electronic and optical (losses and gain)) properties which is a prerequisite to obtaining reliable, high performance, emitting devices. Further, this will allow us to define their field of applications, and in particular to assess the interest of developing other nano-photonic devices. DOMINO will thus open the route to further long-term research on semiconductor nanostructures and nano-photonic devices.",Antimonide Quantum Dots for Mid-Infrared Nano-Photonic Devices,FP6,31 May 2008,31 May 2005,2027919.0 DOSECOPS,University of Plymouth,health,"Corrosion of reinforcing steel in concrete structures is a worldwide problem and affects a large number of infrastructures. Two major causes connected to corrosion of reinforcing steel are the carbonation and chloride attack. Concrete carbonation produces a carbonated surface layer in which the pore solution pH value is depressed to near-neutral levels. A fall in pH to values below 10 at the steel can render the steel passive film thermodynamically unstable and thus cause steel corrosion. While chloride attack causes localised breakdown of the passive film that initially forms on steel as a result of the alkaline nature of the pore solution in concrete. The harmful chloride ions can be originated from the use of contaminated mix constituents or from the surrounding environment such as deicing salts or seawater. The corrosion of steel not only reduces the strength of reinforcement but also can lead to cracking and spalling of cover concrete because of the substantial volume increase that accompanies the transformation of iron to rust. To promote the effective application of reinforced concrete it is important to protect the reinforcing steel from corrosion during its service life. This proposal is to explore a new electrochemical remediation of reinforced concrete structures by combining conventional electrochemical processes, such as the electrochemical chloride removal for chloride contaminated concrete and the electrochemical realkalisation for carbonated concrete, with electrochemical nanoparticle injection. Using the new electrochemical processes, not only can they remove chlorides from concrete and increase alkalinity in concrete pore solution but also simultaneously inject nanoparticles into the concrete to enhance its mechanical properties as well as improve its porosity to stop the further penetration of chlorides and CO2 from its surrounding environment, and thus provide a permanent solution for concrete repair suffered from carbonation and chloride attack.",Development of sustainable electrochemical corrosion protection systems for reinforced concrete structures,FP7,30 June 2016,01 July 2012,327600.0 DOTFIVE,STMicroelectronics SA,manufacturing,"DOTFIVE is a three-year IP proposal for a very ambitious project focused on advanced RTD activities necessary to move the Silicon/germanium heterojunction bipolar transistor (HBT) into the operating frequency range of 0.5 terahertz (THz) (500 gigahertz GHz) enabling the future development of communication, imaging or radar Integrated Circuits (IC) working at frequencies up to 160 GHz . For a given lithography node bipolar transistors and more recently HBT have always lead the frequency race compared to MOS devices, while offering higher power density and better analogue performances (transconductance, noise, transistor matching).The main objective of this highly qualified consortium is to establish a leadership position for the European semiconductor industry in the area of millimeter wave (mmW) by research and development work on silicon based transistor devices and circuit design capabilities and know-how. SiGe HBT is a key reliable device for applications requiring power > few mW (future MOS limitation) and enabling high density, low cost integration compared to III-V. To achieve the goal DOTFIVE unites a powerful consortium:",Towards 0.5 Terahertz Silicon/Germanium Heterojunction Bipolar Technology,FP7,07 July 2013,02 January 2008,0.0 DOTSENSE,Justus Liebig University of Giessen * Justus-Liebig-Universität Gießen,transport,"The objective of DOTSENSE is the application of III-nitride (InxGa1-xN) quantum dots (QDs) and nanodisks (NDs) as opto-chemical transducers for the detection of hydrogen, hydrocarbons and the pH-value in gaseous and liquid environments. The characteristics of intense room-temperature luminescence from III-nitride nanostructures can be altered by chemically induced variations of the surface potential. The transparency of the substrate material and the involved buffer layers allow optical excitation and detection of the changes in QD or ND luminescence from the substrate backside. These transducers are hence capable of operating in harsh environments (high pressure, explosive media), as neither electrical feedthroughs nor a deterministic current are necessary for the sensor signal read-out. Furthermore, spatially-resolved detection of variations in the surface potential is possible, since the spatial extension of excited nanostructures is determined by the diameter of the incident light beam._x000d_",Group III-nitride quantum dots as optical transducers for chemical sensors,FP7,04 June 2013,05 January 2008,0.0 DOTSWITCH,University of Cambridge,photonics,"The project aims at the development of optical switch technologies for packet-switched opti- cal networks, based on semiconductor optical amplifiers (SOAs) using self-organised (InGa)As/GaAs quantum dots (QDs) as active region. QD SOAs exhibit broad gain spectra, ena- bling the amplification of high-bandwidth spectral channels in coarse wavelength division multi- plexed communication systems. Optical routing and switching device technology will be com- bined with novel GaAs-based long-wavelength emitters at 1.3 µm. This interdisciplinary ap- proach combines optical datacom techniques with semiconductor nanotechnology. The project is expected to advance the application of nanotechnology in optoelectronics with the aim of implementing quantum-dot material technology into integrated optoelectronic circuits for larger-bandwidth optical datacom and thus complies with the Thematic Priority 2 (1ST) of FP6. The projects builds on recent evidence that QD systems could be eminently suitable for wide-band switching applications and might substantially improve the performance of next gen- eration datacom systems. The conjunction of both research fields has not been performed to an extent that allows the full exploitation of the advantages of quantum-dot based optoelectronic materials. The applicant, originating from Germany, will benefit from superb training by the host or- ganization, the University of Cambridge (UK). He will gain expertise in combining materials science with research on next-generation photonic datacom solutions. At the end of the fellow- ship, the applicant\\'s scientific skills will range from materials nanotechnology over optoelec- tronic devices up to architectures for future high-capacity all-optical networks. Such a threefold combination of expertise is very rare and will significantly contribute to enhance EU scientific excellence.",Quantum Dots for All-Optical Switching in Optical Data Communication Networks,FP6,31 May 2005,01 December 2003,159046.0 DOTUBE,IMDEA Nanoscience Institute * IMDEA Nanociencia,health,"Many applications in Nanotechnology require the complete understanding of the material`s surface in order to control further interactions against specific targets. The goal of the proposal is to understand the interaction between CdSe nanoparticles and carbon nanotubes (or graphene) as well as the chemical reactivity of such composites. We will investigate the ligand environment of the CdSe nanoparticles attached to carbon nanotubes by means of Nuclear Magnetic Resonance (NMR) spectroscopy as main investigation technique. We expect to obtain evidences of the structural properties (composition of the connected facet), type of interaction (coordinative or ionic) and to evaluate the strength of the bond. Once we understand the cited information, we also expect to improve the carrier injection into the tube by proper chemical functionalization. The results of the chemical studies will be applied to understand the interaction between nanoparticles and carbon nanotubes and to optimize the photoelectrical response.",DOTUBE: Interactions between semiconductor nanoparticles and carbon nanotubes,FP7,30 June 2012,01 July 2009,45000.0 DOUBLENANOMEM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"The main scope of the DoubleNanoMem project is the development of nanostructured membranes based on the most appropriate combination of nanofillers with well-defined size and porosity, dispersed in advanced high free volume polymers with inherent nanoporosity for application in specific gas and vapour separations. This approach is driven by the main requirement for successful replacement of traditional gas and vapour separation processes by membrane-based separations: a radical improvement of the permeability and selectivity compared to state-of-the-art commercially available membranes. The use of nanocomposite and nanostructured membrane materials is seen as one of the few approaches with the real potential to achieve this goal and in this respect several combinations of polymers and nanoparticles will be tested. Different types of nanoparticles will be used, which are all able or have the potential to create preferential channels for mass transport: both single wall and multi wall carbon nanotubes, zeolites, mesoporous silicas and cucurbituril derivatives. The idea is to create a scientific basis for the combination of advanced polymers with suitable nanoparticles, compatible with the corresponding polymers, leading to membranes with unique separation properties. The principle targets of the project are: - Development of membranes with tailored separation performance based on innovative materials - Experimental characterization and development of structure-performance relationships. - Modelling of transport phenomena and of the material's structure to provide a better scientific understanding of gas and vapour transport phenomena and separation processes. - Applied research in a select number of consolidated and emerging areas of gas separation and pervaporation, such as CO2 separation from flue gas, natural gas processing, biofuel production. - Demonstration of the practical applicability of the developed principles and dissemination of the main achievements.",Nanocomposite and Nanostructured Polymeric Membranes for Gas and Vapour Separations,FP7,31 May 2012,01 June 2009,3000000.0 DR-NANO,Ben-Gurion University of the Negev,health,"A fluorescence microscope for the noninvasive imaging of the structure and dynamics in thick 3D systems with 3D sub-diffraction-limited resolution and at extended penetration depths would have a broad spectrum of applications in both the physical and biological sciences. Conventional fluorescence microscopy techniques, such as confocal and two-photon microscopy, lack the spatial resolution required for measurements at the nanoscale, whereas state-of-the-art 3D super-resolution optical microscopy methods offer limited penetration depth (<5 microns). In the proposed project, I aim to develop a new microscope that combines molecular photoswitches, fluorescence self-interference and light-sheet microscopy to optically section a thin layer deep in thick semitransparent samples with 3D sub-diffraction-limited resolution. I will then test it for potential physical and biological applications of single molecule detection. The first specific aim is to develop a depth-resolved self-interference photoswitching nanoscope employing novel high-throughput and sub-diffraction-limit fluorescence interferometry. The second specific aim is to map with 3D nanometer resolution the motion of photoswitchable fluorescent probes deep in soft materials. This study will open up new possibilities for precise measurements of the heterogeneity and mechanical properties of the nanoenvironments of soft matter at extended depths and may ultimately assist in developing superior biomaterials and nanomedical therapeutics. The third specific aim is to in situ image with 3D nanometer resolution the muscle thick filament system in fixed Caenorhabditis elegans nematodes at both the ventral and dorsal ends (separated by ~80 microns). This demonstration, if successful, will provide unique 3D super-resolution in situ image data and may assist in developing imaging protocols for in situ nanoscopy of structural changes of the C. elegans body-wall muscle system due to sarcomeric muscle diseases.",Depth-Resolved Optical Nanoscopy,FP7,31 August 2015,01 September 2011,100000.0 DRAGON,Technikon Forschungs- und Planungsgesellschaft mbH,information and communications technology,"The driving idea behind DRAGON is to research and use new design methodologies and architectural innovation based on reconfigurability and state-of-the-art digital CMOS technology to break the barriers imposed by the lacking scaling properties of analog components. Radio transceivers serve as an exemplary case with high impact value. With this concept we seek to achieve distinct reductions in cost, size and energy consumption for multi-standard cellular handsets, and other products employing similar technology, while meeting higher demands on data rate.",Design methods for Radio Architectures GOing Nanoscale,FP7,05 July 2015,02 January 2010,0.0 DREAMS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"Electrical stimulation of neurons is a recognised therapeutic approach for the treatment of neurodegenerative pathologies (Parkinson disease etc). These techniques could have a high impact on treatments of other pathologies like epilepsy or blindness. Available commercial devices based on metalised electrodes degrade in physiological environments and induce reactive gliosis, incompatible with fabrication of implants, where a long term stability is mandatory and a closer neuro-electronic interface is required to lower the neuronal activation threshold. The high resolution required for vision and the stimulation of graded potential neurons need complex and very precise stimulators. DREAMS propose to study and fabricate novel types of nanotransducers, based on artificial nanocrystalline diamond (NCD), that exhibits extreme biocompatibility and stability in physiological media. NCD coated and functionalised metallic electrodes or non metalised CMOS devices will be fabricated, leading to novel active neural cell-hybrid structures and biocompatible implants to restore a useful vision. Survival of neurons and retinal cells will be evaluated and in-vitro stability and the ability to activate neurones will be tested. DREAMS will lead to the fabrication of matrixes of Field Effect Transistors that can be validated for stimulation of the retina as well as for readout of the retinal signals in-vivo.",DIAMOND to RETINA ARTIFICIAL MICRO-INTERFACE STRUCTURES,FP6,30 April 2010,01 November 2006,1399996.0 DROEMU,University of Padua * Università degli Studi di Padova,health,"The applications of micro- and nanofluidics are now numerous, including lab-on-chip systems based upon micro-manipulation of discrete droplets, emulsions of interest in food and medical industries (drug delivery), analytical separation techniques of biomolecules, such as proteins and DNA, and facile handling of mass-limited samples. The problems involved contain diverse nano- and microstructures with a variety of lifetimes, touching atomistic scales (contact lines, thin films), mesoscopic collective behaviour (emulsions, glassy, soft-jammed systems) and hydrodynamical spatio-temporal evolutions (droplets and interface dynamics) with complex rheology and strong non-equilibrium properties. The interplay of the dynamics at the different scales involved still remains to be fully understood. The fundamental research I address in this project aims to set up the unified framework for the characterization and modelling of interfaces in confined geometries by means of an innovative micro- and nanofluidic numerical platform. The main challenging and ambitious questions I intend to address in my project are: How the stability of micro- and nanodroplets is affected by thermal gradients? Or by boundary corrugation and modulated wettability? Or by complex rheological properties of the dispersed and/or continuous phases? How these effects can be tuned to design new optimal devices for emulsions production? What are the rheological properties of these new soft materials? How confinement in small structures changes the bulk emulsion properties? What is the molecular-hydrodynamical mechanism at the origin of contact line slippage? How to realistically model the fluid-particle interactions on the molecular scale? The strength of the project lies in an innovative and state-of-the-art numerical approach, based on mesoscopic Lattice Boltzmann Models, coupled to microscopic molecular physics, supported by theoretical modelling, lubrication theory and experimental validation.",DROPLETS AND EMULSIONS: DYNAMICS AND RHEOLOGY,FP7,30 November 2016,01 December 2011,1170923.0 DRUG DELIVERY SYSTEM,University of Neuchatel * Université de Neuchâtel,health,"We propose to develop and implement mathematical models and tools for the design and evaluation of martensitic ultra-thin film based micro-devices. Our primary objective is to design a family of martensitic micro-devices and to investigate their applicability as the open loop drug delivery systems. We will investigate their applicability for specific diseases where more potent drugs are available but not applicable due to their undesirable side effects. Significant portion of our activity will be carried out in collaboration with mathematicians, materials scientists and medical research doctors to initiate micro-fabrication of functional samples and to provide in-vitro testing of the proposed technology.Significant portion of the EXC activity will be devoted to lecturing, teaching and directing two Ph.D. students. We will develop four courses to complement the curriculum of the University of Neuchatel. Namely, we will offer the following courses (1) mathematical approaches to the thermodynamics of structured solids, (2) mathematical theory of crystalline thin films, (2) application of stochastic processes in multi-scale materials science, (4) advanced numerical methods for approximation of the measure-valued descriptors of nano-systems.The two Ph.D. Thesis will be (1) Methods for computational modeling of multi-functional materials with the focus on the martensitic thin films, (2) Mathematical design, evaluation and micro-fabrication of the micro-devices applicable to the open loop Targeted drug delivery in the specific form of the martensitic ultra thin film micro-actuators.The proposed research contributes to the area of emerging science and technologies. The activity is designed to focus on the area of nano-technologies and nano-sciences, multifunctional materials and new devices.",Collaborative Mathematical Research Applicable To Martensitic Micro-devices And Their Use For The Design Of The Open Loop Targeted Drug Delivery Systems,FP6,30 June 2009,01 July 2006,480915.46 DSIDMO,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"The project of the post doctoral stay of the candidate in the Laboratory of Macromolecular and Organic Chemistry is depicted in this proposal. The host group, headed by Prof. E. W. Meijer, plays a world leading role in the fields of supramolecular chemistry and dendrimers. Because of their well defined structure and multivalent character, dendrimers are promising nanoscopic structures for biomedical applications, including imaging and drug delivery. The research interest of the candidate as a predoctoral researcher has been the design and characterisation of new liquid crystalline materials based on dendrimers. With this project the candidate aims at getting experience in the study of dendritic systems in solution, specially in aqueous media envisaging biomedical applications. The techniques needed for these studies and the training required are available at the host organisation which also has as its first priority the training of young researchers. The candidates scientific background fits perfectly the profile of a postdoctoral fellow in the host research group. The experience gained by the candidate with this project is also of interest for the recently founded Institute of Nanoscience at his home university. Furthermore this postdoctoral stay is also aimed to be the starting point of future collaborative research work between the host group and the home university of the candidate. We would like to focus our investigation in the preparation and characterization of guest-host systems stable in water based on dendrimers. We are interested in the analysis of the complexation between guest and host by mass spectrometry, nuclear magnetic resonance spectroscopy, light scattering and cryogenic transmission electron microscopy. The host group have experience in training at an advanced level within the field of research, as well as outstanding equipment for these studies.",Dendrimers and supramolecular interactions for the design of multivalent objects,FP6,31 March 2008,01 January 2007,149275.67 DT-CRYS,Research Association Berlin * Forschungsverbund Berlin eV,health,"This proposal aims at the systematic study of double tungstate crystals for different applications. Special attention will be given to the unique multifunctional properties of double tungstates. Members of the double tungstate crystal family will be synthesized and manufactured in different geometries, with emphasis on nano-crystalline, bulk, thin-film, planar- and channel-waveguide, and nano-periodic photonic band-gap structures. The fundamental structural, thermo-mechanical and damage-resistivity, magnetic, optical, nonlinear-optical and waveguiding properties will be studied. Doping and codoping with various rare-earth ions up to the stoichiometric compositions and spectroscopy of these ions in double tungstates will be performed. Studies into the various applications of these multifunctional materials will span the range from high- power diode-pumped, highly efficient solid-state bulk, thin-film and waveguide lasers, ultrafast lasers, nano-crystalline and photonic band-gap devices, second- and third-order nonlinear optical devices, optical cooling through anti-Stokes fluorescence, magnetic cooling through adiabatic demagnetization and scintillating particle detectors to applications that combine several of these features in a single device, such as self-frequency-doubled and Raman lasers or optically cooled high-power lasers. By tailoring the composition, doping, and geometry of the devices, we will be able to realize highly efficient, compact, reliable and inexpensive tools for implementation in material processing, medicine, biology, and defence-related applications. A consortium with six academic and three industrial partners (SMEs) from six European countries, including one candidate country, all with extensive experience and international recognition but complementary skills and tasks in the project, has been designed to fulfil the above program.","Double Tungstate Crystals: synthesis, characterization and applications",FP6,31 March 2007,01 April 2004,2144194.0 DUALLOGIC,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"We propose to develop for the first time a dual-channel CMOS technology comprising high channel mobility (high-µ) Ge pMOS and III-V compound semiconductor nMOS transistors co-integrated on the same complex engineered substrate on Si. This offers a high performance booster as an option for the 22 nm technology creating competitive advantage for the European nanoelectronics industry. In addition, high-µ dual channel CMOS could be the main new introduction in sub-22 nm nodes in agreement with the strategic planning of the ENIAC technology platform. The project will develop the full set of FEOL modules from the starting local GeOI substrate to the dual-channel engineered substrate, the high-k/metal gate stacks and the S/D junctions with low resistivity contacts. Our aim is to use surface inversion channels and a self-aligned process with implanted S/D contacts for both III-V and Ge MOSFETs to ensure compatibility with the scaling and operation rules of CMOS. Device modelling and circuit design will assist in selecting the most suitable device architecture. The technology will be validated by the successful co-integration of short channel functional transistors using a 65 nm/200 mm pilot semiconductor processing line. This will allow characterization in terms of mobility at short gate lengths and identification of possible showstoppers associated with the behavior of high-µ channels at nanoscale dimensions. In addition, using toolsets, process flows and know how similar to Si, we aim at demonstrating that the high-µ dual channel technology is scalable and manufacturable without the need for introducing costly and disruptive technologies, thus ensuring the CMOS evolution for next generations. Mobilizing major technology development laboratories in Europe along with leading semiconductor and information technology industry and key semiconductor equipment manufacturers, this project can be a catalyst to the effort for maintaining competence in manufacturing and IP in Europe",Dual-channel CMOS for (sub)-22 nm high performance logic,FP7,30 May 2011,01 December 2007,5799338.0 DUALNANOTHER,Paris Diderot University * Université Paris Diderot - Paris 7,health,"This project is designed to provide answers to questions not yet covered in the literature regarding hyperthermia cancer therapy based on the activation of magnetic and/or plasmonic nanomaterials. It aims at understanding and measuring nanoparticle-based heat-generating potential in environments that gradually approach the in vivo situation. The originality of the approach proposed is to combine in-depth physical studies (magnetic, plasmonic) of nanomaterials in biological environment while exploring new therapeutic modalities. Two main issues will be addressed: (1) the influence of magnetic or plasmonic nanoparticle confinement inside cells on heat-generating potential; (2) the possible synergism between magnetic and plasmonic hyperthermia, with a view to combined therapy, and their cumulative efficacy in solution, in vitro cell models, and in vivo tumour models. These issues will be addressed at several levels, ranging from materials chemistry to antitumoral applications in living animals, by exploiting multiple disciplines. To open the way to new therapeutic tools, it will be necessary to test a wide variety of nanoparticles with different compositions, shapes and sizes, provided by leading teams in nanomaterials synthesis, as well as to develop appropriate nanometrologic methods to detect, quantify and characterize the different nanostructures in their biological environment.",Dual cancer nanotherapies combining magnetic and plasmonic hyperthermia,FP7,31 March 2016,01 April 2014,194046.0 DUCTILE BMG COMPOSITES,Grenoble Institute of Technology * Institut polytechnique de Grenoble,energy,"Springs and other mechanical energy storage parts made of crystalline alloys will undergo certain "ageing" each time the applied load takes them beyond their elastic limit near the 0.2% strain offset. Springs made of bulk metallic glasses (BMG) are in principle far superior since their elastic limits are at 2% strain. However, if this limit is surpassed, they will fail by fracture. On the other hand the ductile BMG-composites proposed by the present project will not only maintain the superior 2% elastic limit, but their near 10% room-temperature plasticity will avoid failure beyond the elastic limit until replaced at the end of a far longer operational life-time.Plastic deformation and dislocation interactions in crystalline materials produce strain-hardening but shear banding in metallic glasses leads to strain-softening and rapid shear-off failure. The partners of the present proposal have shown that the introduction of appropriate dispersions of nanoscale or micron scale crystallites into the BMG matrix arrests or retards strain-softening by containment of shear band activity thus requiring shear
band branching in the BMG matrix and higher mechanical work prior fracture. The result is the emergence of a plastic deformation regime beyond the characteristic 2% elastic and fracture strain range of BMGs. Enabling BMG-based materials to undergo significant plastic deformation beyond their characteristic 2% strain regime via composite formation is technologically ground-breaking with possible strategic industrial significance. This is the objective of the proposed Network that integrates leading experts of 11 research teams from 7 EU members and 1 future member country as well as the European Synchrotron Radiation Facilities (ESRF) with state-of-the-art
expertise in phase diagram and electronic structure calculations, alloy design and characterisation, mechanical properties, various casting methods, sophisticated equipment for preparation, structural #",Ductilisation of Bulk Metallic Glasses (BMGs) by Length-scale Control in BMGs Composites and Applications,FP6,31 December 2007,01 January 2004,2049279.0 DUPLEX,University of Sheffield,manufacturing,"The unique properties of nucleic acids have made them the material of choice for complex nanofabrication. High fidelity formation of duplexes via non-covalent interactions between complementary sequences provides a straightforward approach to molecular programming of multicomponent self-assembly processes. The structure of the nucleic acid backbone and bases can be changed without destroying these properties, suggesting that there are all kinds of unexplored polymeric structures that will also show sequence selective duplex formation. This proposal investigates this rich new area at the interface of supramolecular, biological and polymer chemistry. The appeal of nucleic acids is that we can dial up any desired sequence via chemical solid phase synthesis or via biological template synthesis. With recent advances in polymerisation processes, which proceed under mild conditions compatible with non-covalent chemistry, we are now in a position to develop comparable processes for synthetic polymers. This proposal explores a ground-breaking approach to the synthesis of polymeric systems equipped with defined sequences of recognition sites. The aim is to establish protocols for routine solid phase synthesis of one class of oligomer, which can be used to template the synthesis of different classes of oligomer. This template chemistry will provide tools for polymerisation of conventional monomers using templates to determine the sequence of recognition sites and hence incorporate the selective recognition properties of nucleic acids into bulk polymers like polystyrene. The ability to program polymers with recognition information will open the way to new materials of unprecedented complexity and functionality with applications in all areas of nanotechnology where precise control over macromolecular structure and supramolecular organisation will be used to program mechanical, photochemical and electronic properties into sophisticated assemblies that rival biology.",Programmable Plastics,FP7,02 April 2020,03 January 2013,2457946.8 DURABROADS,University of Cantabria * Universidad de Cantabria,construction,"The objective of the DURABROADS project is the design, development and demonstration of cost-effective, eco-friendly and optimized long-life roads, more adapted to freight corridors and climate change by means of innovative designs and the use of greener materials improved by nanotechnology. The optimization of current construction, maintenance and rehabilitation procedures is also aimed in this project.",Cost-effective DURABle ROADS by green optimized construction and maintenance,FP7,03 July 2019,10 January 2013,0.0 DVT-IMP,Teesside University,health,"Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE) are major causes of unexpected mortality in hospitals throughout Europe. D-dimer is a recognised biomarker for the diagnosis of a thrombus and is routinely examined in hospital laboratories using a traditional ELISA technique. The clinical need for a fast predictive test for D-dimer has prompted the development of test kits, some of which are deployed at the point-of-care as a means of guiding clinicians. Current D-dimer point-of-care diagnostic kits do not provide accurate, quantitative analysis ? creating uncertainty amongst clinicians who are unable to exclude DVT/PE as a result, and consequently unnecessarily refer many patients for high-cost Doppler ultrasound imaging, creating pressure on healthcare services across Europe. The consortium, industrially driven by a leading healthcare supplies provider, incorporating skilled SMEs in electro-analysis instrumentation and bio-engineering and including academic bases in clinical pharmacology, microelectronics, analytical electrochemistry and micro-fabrication ? aims to integrate four key technologies areas: Bio-engineered antibodies for high specificity immunoassay diagnostics Nano/micro engineered impedimetric analysis electrodes incorporating bio-compatible conducting polymer substrates for enhanced detection capabilities Development and packaging of a disposable, sterile, microfluidic manifold enabling diagnostics at the point-of-care Developing e-Health diagnostic software toolkit for high positive and negative predictivity D-dimer tests DVT-IMP will innovation bio-nano/micro-informatic technologies that will enable the development of a point-of-care device with advanced diagnostic capabilities, including the output of quantitative D-dimer levels, thus increasing confidence and certainty for clinicians, enabling them to confirm or exclude the risk of DVT/PE using the high negative and positive predictive capabilities of the DVT-IMP prototype",Deep Vein Thrombosis - Impedimetric Microanalysis System,FP6,28 February 2010,28 August 2006,3283763.0 DW DYNAMICS,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"Precise control of magnetization reversal in patterned magnetic nanostructures is a key parameter for future application in random access memories, hard disk media and, more recently, in magnetic logic devices. In the latter case, it has been demonstrated that magnetic elements could perform logic operations analogously to current microelectronic devices and a very promising scheme based on magnetic domain wall (DW) propagation in magnetic nanostructures has been proposed. However, the relationship between DW dynamics and the structural and magnetic properties is not well understood. The aim of this project is both to understand and optimize the dynamics of domain wall propagation in magnetic nanostructures. Thus, new epitaxial magnetic multilayers, based on binary alloys (FePt, FePd?) will be used to understand better the relationship between the microstructure and the magnetic properties. The influence of the microstructure (grains, chemical order?), defects (intrinsic or induced by patterning), geometry of the nanostructure, magnetic features (anisotropy, DW width, DW type, exchange biased DW?) on DW dynamics will be studied by time resolved magnetotransport measurements. Single artificial defects will further be incorporated by nanolithography techniques in order to study the DW-single defect interaction. The final objective is to optimize the DW velocity and to drive it precisely in a nanocircuit between given positions, which is of great interest for the development of novel devices based on DW propagation capable of storing information or performing logical operations. The applicant and apos;s contrasted experience on the fabrication of magnetic epitaxial nanostructures and on the magnetic domain wall propagation and his collaborations with national and international laboratories, as well as the quality and experience on magnetism of the laboratory members that has accepted the applicant are highly suitable to successfully develop this project.",Dynamics of domain wall propagation in epitaxial magnetic nanostructures for applications to spintronic devices,FP6,31 December 2005,01 January 2005,40000.0 DW_FDTP_UVA,University of Vienna * Universität Wien,health,"The terrestrial C and N cycles are essential for the Earth's biosphere and intimately linked by microbial activity. Understanding the participants and drivers rendering biologically available N is imperative as N is a limiting factor for primary production. Soils contain the largest pool of C on Earth with cellulose being a major constituent of this C. Therefore understanding this process is essential since it can either promote C sequestration or be a source of atmospheric CO2. My NanoSIMS group in the Department of Microbial Ecology at the University of Vienna focuses on the investigation of two microbial key processes; plant polymeric carbon degradation and nitrogen fixation. Our goal is to understand the active drivers of these processes and their in situ contributions, the degree of efficiency and regulation mechanisms using a multidisciplinary approach combining methods of biogeochemistry, molecular biology, ecology, soil science, and bacterial physiology. It is timely to now apply a functional approach to study the aforementioned processes due to the recent advance in single cell approaches. To identify the active participants of the two processes, we propose to combine stable isotope probing experiments (15N2 gas or 13C-cellulose) with cell identification with FISH/HISH, Raman microspectroscopy and NanoSIMS. These single cell techniques allow comparing the in situ activities of different microbial groups and the analysis of within population heterogeneity. We aim to differentiate the contributions of cellulose-degrading fungi and bacteria, as well as targeted groups within the bacteria. Second, we aim to better characterize participants in soil N2 fixation with particular emphasize on novel groups who are believed to be highly active. The synthesis of stable isotope probing experiments with single cell genomics will allow us to identify novel microorganisms of the targeted function and describe their ecophysiology in the soil.",Understanding functional drivers in two terrestrial key processes- nitrogen fixation and cellulose degradation- by a single cell approach,FP7,31 July 2016,01 August 2012,100000.0 DYCOCA,University of Padua * Università degli Studi di Padova,health,"Molecular recognition plays a fundamental role in nearly all chemical and biological processes. The objective of this research project is to develop new methodology for studying and utilizing the noncovalent recognition between two molecular entities, focussing on biomolecular receptors and catalysts. A dynamic covalent capture strategy is proposed, characterized by the following strongholds. The target itself self-selects the best component out of a combinatorial library. The approach has a very high sensitivity, because molecular recognition occurs intramolecularly, and is very flexible, which allows for an easy implementation in very diverse research areas simply by changing the target. The dynamic covalent capture strategy is strongly embedded in the fields of supramolecular chemistry and (physical) organic chemistry. Nonetheless, the different work programmes strongly rely on the input from other areas, such as combinatorial chemistry, bioorganic chemistry, catalysis and computational chemistry, which renders the project highly interdisciplinary. Identified targets are new synthetic catalysts for the selective cleavage of biologically relevant compounds (D-Ala-D-Lac, cocaine and acetylcholine, and in a later stage peptides and DNA/RNA). Applicative work programmes are dedicated to the dynamic imprinting of monolayers on nanoparticles for multivalent recognition and cleavage of biologically relevant targets in vivo and to the development of new screening methodology for measuring chemical equilibria and, specifically, for the discovery of new HIV-1 fusion inhibitors.",DYNAMIC COVALENT CAPTURE: Dynamic Chemistry for Biomolecular Recognition and Catalysis,FP7,30 September 2014,01 October 2009,1400000.0 DYNAMAG,University of Exeter,photonics,"The opportunity to modify the excitation spectra in materials with modulated properties has stimulated striving research activity in the area of artificial nanostructures with novel functionalities - so called metamaterials. Magnetic materials with modulated properties also possess properties that cannot be reduced to those of their constituents. The best example is the phenomenon of giant magneto-resistance (GMR), the discovery of which was marked by the Nobel Prize in Physics last year. Similar to photons in photonic crystals, the spectrum of magnons (spin waves) in periodic magnetic nano-materials shows a tailored band structure. The latter consists of bands of allowed magnon states and band gaps in which there are no allowed magnon states. By analogy to studies of other band-gap materials, the field of research is called magnonics. Further development and application of magnetic nano-structures requires a thorough understanding of the relation between their physical and chemical structure and useful magnetic functionalities. The ability to accurately predict properties of fabricated magnetic nano-structures and complete devices theoretically would generate huge savings of resources, but remains illusive at present. The goal of this project is to consolidate efforts of European and Indian researchers with a broad range of leading expertise to create, to validate and to implement a flexible computational framework for modelling of dynamics in realistic magnetic nano-materials and complete devices. The framework will be validated via comparison of computational results against those obtained experimentally or using analytical theories. We will model magnetic dynamics in topologically complex nanostructures, in view of applying them in design of realistic devices. This project will provide a computational foundation for creation of not only novel high speed magnetic technologies but also of those at interfaces with photonics, plasmonics, phononics, and electronics.",ADVANCED COMPUTATIONAL STUDIES OF DYNAMIC PHENOMENA IN MAGNETIC NANO-MATERIALS,FP7,31 May 2012,01 June 2009,899936.0 DYNAMAX,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"DynaMax will validate recent theoretical and experimental insights into the coupled current and magnetization dynamics of nanoscale ferromagnetic heterostructures for magnetoresistive read heads, hard-disk media, and novel MRAM elements. The DynaMax consortium consists of experts in magnetoelectronics who cover the complete chain from theory, over computational materials science and device simulation to device fabrication and measurements of current and magnetization dynamics. We will accurately model the magnetization motion with small amplitudes as relevant for read heads up to the full magnetization reversal in memory elements. Recently discovered physics such as current-induced spin-transfer torques, the spin-current mediated cross talk, enhanced magnetization damping as well as noise that couples the fluctuations of the currents with those of the magnetization will be taken into account. Specific topics to be addressed are the realistic simulation of perpendicular and lateral magnetoelectronic devices made from standard and metallic materials such as Heusler alloys that will be thoroughly tested by the experiments. The main deliverables is a unique simulation code that reliably models the micromagnetism as well as the charge and spin current dynamics of laboratory structures to such a detail that it has predictive value for application in an industrial environment.",Dynamic Magnetoelectronics,FP6,28 February 2010,28 August 2006,2000000.0 DYNAMO,University of the Basque Country * Universidad del País Vasco / Euskal Herriko Unibertsitatea,energy,"Scope 'Energy Materials. In this project we develop new concepts for building a novel theoretical framework (the ab-initio non-equilibrium dynamical modelling tool') for understanding, identifying, and quantifying the different contributions to energy harvesting and storage as well as describing transport mechanisms in natural light harvesting complexes, photovoltaic materials, fluorescent proteins and artificial (nanostructured) devices by means of theories of open quantum systems, non-equilibrium processes and electronic structure. We address cutting-edge applications along three major scientific challenges: i) characterize matter out of equilibrium, ii) control material processes at the electronic level and tailor material properties, iii) master energy and information on the nanoscale. The long-term goal is developing a set of theoretical tools for the quantitative prediction of energy transfer phenomena in real systems. We will provide answers to the following questions: What are the design principles from the environment-assisted quantum transport in photosynthetic organisms that can be transferred to nanostructured materials such as organic photovoltaic materials and biomimetic materials? What are the fundamental limits of excitonic transport properties such as exciton diffusion lengths and recombination rates? What is the role of quantum coherence in the energy transport in photosynthetic complexes and photovoltaic materials? What is the role of spatial confinement in water and proton transfer through porous membranes (nano-capillarity)? The ground-breaking nature of the project lies in being the first systematic development and application of the theories of open quantum systems and quantum optimal control within an ab-initio framework (time-dependent-density functional theory). The project will open new methodological, applicative and theoretical horizons of research.",Dynamical processes in open quantum systems: pushing the frontiers of theoretical spectroscopy,FP7,31 March 2016,01 April 2011,1877497.0 DYNANIMAG,University of Nottingham,information and communications technology,"This proposal aims to develop a common framework to describe the properties of Molecular Nanomagnets (MNM) and Magnetic Nanoparticles (MNP). We will study the magnetic anisotropy and the spin dynamics in such nanomagnets. The former is the critical and fundamental property for application of nanomagnets as novel ultrahigh density magnetic data storage devices. We will investigate both types of nanomagnets using a wide range of experimental techniques under similar conditions allowing direct comparison of their properties. We will further the knowledge and understanding of the origin of magnetic anisotropy in both types of nanomagnets, leading to a generalized description of this property. The outcomes of this project will outline the way to the development of vastly improved data storage materials. In addition, we will study the spin dynamics using pulsed electron spin resonance. Detailed investigations of the spin-lattice relaxation will elucidate the microscopic mechanisms of magnetization relaxation, especially in nanomagnets with large spin state densities. Investigation of spin-spin relaxation will establish the possibility of measurable quantum coherence in large MNM as well as in MNP. This will further our understanding of how the quantum world of small particles transforms into the classical world that we live in. The outcomes will also allow assessment of the suitability of nanomagnets for quantum computing applications. The project will deliver a highly trained promising researcher accelerating his progress towards becoming a leading independent researcher. The detailed Career Development Plan ensures extensive scientific and complementary training. The project also foresees a number of research visits in various EU laboratories enhancing the experience and mobility of the researcher. The planned dissemination activities will also stimulate public engagement with science.",Towards a unified description of dynamics and anisotropy in nanomagnets,FP7,04 June 2014,05 January 2010,173240.8 DYNASLIPS,Aalto University * Aalto-yliopisto,manufacturing,"Biomimetics and bioinspiration have been proven to be fruitful approaches to designing novel liquid and dirt repellent coatings. For example, lotus-mimetic superhydrophobic surfaces have gained enormous amounts of interest during the past 10-20 years. Today, superhydrophobic coatings are making their commercial breakthrough and can be bought from hardware stores and sprayed on practically any surface. However, another class of bioinspired repellent surfaces is emerging at the moment. This new type of coating has the potential to overcome many of the problems associated with lotus-mimetic superhydrophobic surfaces, such as the poor durability and lack of omniphobicity.",Dynamic Flow Control and Self-Assembly on Bioinspired Slippery Surfaces,FP7,08 July 2019,09 January 2014,0.0 DYNASPINE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Synapses are physical sites of communication that transmit and transform information between neurons in a very rapid and dynamic way. Not surprisingly, malfunctioning synapses are at the root of some of our most prevalent neurological and psychiatric disorders. As synapses are smaller than what diffraction-limited light microscopy can resolve, and densely packed in light-scattering brain tissue, it has been extremely difficult to study their physiology in mechanistic terms. As a result, we still lack an understanding of the basic dynamic organization of neurotransmitter receptors and their molecular partners at mammalian synapses. While electron microscopy provided detailed snapshots of where glutamate receptors are located inside synapses, this technique does not convey dynamic or functional information. Since existing optical approaches, such as 2-photon glutamate uncaging, do not have sufficient spatial resolution, progress in this area relies on fundamental breakthroughs in live-cell-compatible techniques relying on focused visible light. We propose to utilize novel STED superresolution microscopy to image and concurrently activate synapses in live spines by superresolution STED photo-uncaging of glutamate. STED microscopy offers optical resolution an order of magnitude higher than current 2-photon or confocal techniques, and we aim to unravel functional and structural nano-dynamics of spines and synapses during plasticity. Specifically, as part of a collaborative effort, we will (1) evaluate newly engineered photosensitive glutamate-containing compounds for superresolution STED-based photo-activation, (2) advance STED microscopy technology to concurrently activate and image synapses beyond the diffraction limit, and (3) use this new methodology to probe synaptic physiology in brain slices with unprecedented resolution. These advances will enable us to address timely questions regarding the dynamic behavior of neurotransmitter receptors in individual spines.",Nanoscale Photoactivation and Imaging of Synaptic Spine Dynamics,FP7,28 February 2014,01 March 2012,186748.0 DYNEFI,University of Fribourg * Université de Fribourg,health,"Dynamic Light Scattering is a widespread technique for measuring fluid properties in soft matter. It is used to investigate complex fluids, colloids, proteins, nano-particles, but also samples of bio-physical and medical interest. The advent of pixilated sensors like CCD cameras and fast computers allowed the design of different imaging techniques aimed at providing the same quantitative information. Dynamic Near Field Imaging (DyNeFI) is a family of novel optical techniques of this kind. Different variants of this new approach have been successfully designed and used for very refined measurements, nevertheless the soft matter community is not aware of this intriguing possibility. The proposed project aims at: increasing the measuring capabilities of DyNeFI by the integration of new measuring concepts, applying it to samples coming from different research areas thus providing new science and starting developing instruments which can be commercialized in a next future. Essentially the project can be divided into three modules: A) Investigation of the dynamics of the transition between capillary waves and non equilibrium fluctuations in a critical binary mixture undergoing phase transition in order to get deeper insight of the dissolution of an interface between two fluid phases and also provide a tool to measure the effective surface tension B) Application of the technique to micro-rheological measurements, in order to compare the Dy-NeFI technique with other tools for measuring the viscoelastic properties of complex fluids C) Extension of the technique to fast dynamics, through Micro Mirror Device concept, in order to overcome the major disadvantage of the technique, which is the limited ability to investigate fast dynamics",Dynamic Near Field Imaging,FP7,31 October 2012,01 November 2010,180470.0 DYNSPIN,National Institute of Standards and Technology (NIST),information and communications technology,"Nowadays, the trend in high density magnetic recording technology is to replace the current-in-plane (CIP) geometry in magneto-resistive heads for computer disk drives by the current perpendicular to the plane (CPP) configuration. The current densities used in the CPP-GMR heads are of the same order of magnitude as the currents at which spin-torque induced magnetic excitations are observed. Such effects can generate noise and influence the biasing of the magnetic heads. On the other hand, recent experiments showed that a spin-polarized current can drive the magnetization of a layer into steady precessional modes inaccessible by applying only a magnetic field. The frequency of the oscillations is of the order of GHz and can be tuned by changing the current. A small alternative current added to the constant electrical bias generates a frequency modulated spectral output. The purpose of this project is to achieve a better understanding of current induced magnetization precession and answer two important questions for microelectronics: 1.minimize the effects of spin-transfer and propose a CPP-GMR head architecture which is not affected by spin induced parasitic noise; 2.find the parameters which can maximize the output power and investigate different device architectures for new design of microwave oscillators. We propose the investigation of several structures, none of which have been studied before. The post-doc undertake the fabrication and the characterization of the samples, and simulations for the result interpretation. The Outgoing Host Organization has already developed the fabrication process and the necessary experimental set-up, as well as appropriate theoretical models and simulation tools. The post-doc will benefit from working together with world-class specialists in the field. The return phase will be concerned with improving the set-up available at SPINTEC, and proposing an optimized microwave oscillator and noise-free head.",Study of dynamic spin-transfer induced effects for applications to microwave oscillators,FP6,31 August 2007,01 September 2005,0.0 E-BRAINS,Infineon Technologies AG,energy,"Best-Reliable Ambient Intelligent Nanosensor Systems -e-BRAINS -represent a giant leap for outstanding future applications in the area of ambient living with the ultimate need for integration of heterogeneous technologies, high-performance nanosensor devices, miniaturization, smart wireless communication and best-reliability. e-BRAINS with minimum volume and weight as well as reduced power consumption can be utilized in ambient living systems. Successful market entry of such innovative ambient intelligence products will be determined by the performance improvement achieved and the cost advantage in relation to the total system cost. The basic requirement for robustness and reliability of the heterogeneous integration technologies and the nanosensor layers is in the focus of all e-BRAINS developments. The designated nanosensor systems represent a very promising innovative approach with the potential to enable high-performance and precise functions in new products. The application of nanotechnology will allow large improvements in functionality and will open a wide range of applications for European companies. Future e-BRAINS applications require significantly higher integration densities. Performance, multi-functionality and reliability of such complex heterogeneous systems will be limited mainly by the wiring between the subsystems. Suitable 3D integration technologies create a basis to overcome these drawbacks with the benefit of enabling minimal interconnection lengths. In addition to enabling high integration densities, 3D integration is a very promising cost-effective approach for the realization of heterogeneous systems. Besides the heterogeneous system integration the main criteria of e-BRAINS is the need for miniaturized energy storage/delivery systems, low power consumption, smart communication and methodology for reliability and robustness. e-BRAINS benefits from the established European 3D technology platform as major result of the IP e-CUBES.",Best-Reliable Ambient Intelligent Nano Sensor Systems,FP7,28 February 2014,01 September 2010,1.0E7 E-CONTROL,Aalto University * Aalto-yliopisto,information and communications technology,"The aim of the proposed research is to study electric-field induced magnetic phenomena in thin-film ferromagnetic-ferroelectric heterostructures. In particular, the project addresses ferroic order competition and magnetoelectric coupling dynamics at micro, nano, and atomic length scales.","Electric-Field Control of Magnetic Domain Wall Motion and Fast Magnetic Switching: Magnetoelectrics at Micro, Nano, and Atomic Length Scales",FP7,09 June 2019,10 January 2012,0.0 E-CUBES,Infineon Technologies AG,information and communications technology,"As electronic sensor systems are becoming more complex and individualised, standard state of the art approaches will not be anymore appropriate to meet the objectives (cost, reliability, time to market, etc.) of the future. The innovative approach presented here will realize e-CUBES, .i.e. investigate and develop ¿small sensor cubes¿ which are wireless communicating among each other. The e-CUBES will build-up an ad-hoc network to realize the desired system functionality. e-CUBES addresses various multi-disciplinary applications in the important field of wireless sensor networks, with special emphasis but not limited to the following key application areas: - Distributed smart monitoring for Aeronautics and Space applications; - Wireless sensor networks for Health and Fitness; - Distributed intelligent Automotive Control. Particular focus of e-CUBES is on the following technologies: - Individual technologies at various layer levels, suitable for 3D integration; - Layer processing/thinning technologies for 3D integration; - 3D assembling and packaging; - New communication means, e.g. antennas, passive and RF integration, and communication networks; - Power supply and power management for portable applications; - Design methodologies for the 3D SoC and related simulation tools. The e-CUBES technology poses particular challenges with regard to the desirable sizes (a few cubic millimetres), the need to achieve continuous operation through an integrated or external wireless power supply, and the necessity of allowing multiple e-CUBES to communicate. The system is characterized by a large number of individual interconnected e-CUBES. The 'e-CUBES' vision therefore represents a new approach to systems integration that will help to develop complex, flexible and cost-efficient.",3-D-Integrated Micro/Nano Modules for Easily Adapted Applications,FP6,31 July 2009,31 January 2006,1.1999999E7 E-DNA-T-PEP,Technische Universiteit Delft * Delft University of Technology,health,"The proposal aims to understand and control the transport of DNA in electroporation process at the molecular/subcellular level such that more efficient and safer non-viral gene delivery can be achieved. The introduction of naked DNA into living cell via non-viral routes is the safest approach in gene therapy. Electroporation is the electrical disruption of biological membranes to introduce naked DNA into the cell. Due to our lack of information about fundamentals of electropores formation and DNA electrotransfer, electroporation methods still suffer from low transfection efficiency, random uptake and excessive cell damage. The main barriers to achieving this goal are: i) understanding the creation of electropores at molecular level; ii) understanding the underlying mechanism of DNA transport across the membrane of a cell during and after electric pulses and iii) controlling the electrotransfer of DNA through these pores into a cell at molecular level. It is almost impossible to overcome these barriers based on our current rudimentary understanding of cell electroporation. The successful outcome of this project will significantly aid the development of gene delivery into living cells, which will lead to electroporation-based therapies in the near future.To this end, I will apply a multidisciplinary approach, combining disciplines as physical chemistry, transport phenomena, DNA dynamics, biophysics and cell biology. To unveil the entire electroporation process, innovatively I will employ the integrated atomic force microscopy with micro/nanofluidics to visualize the evolution of pore size/density at the membrane level. Furthermore, to understand the DNA electrotransfer, I will study how DNA interacts with electropores and moves through them using optical tweezers and single-molecule FRET. Finally, I will dissect the role of cytoskeleton on the transport of DNA, by mapping out the relationship between the viscoelasticity of cell and location of DNA inside the cell.",Engineering DNA transfer into Cells by Precision in Electroporation,FP7,30 September 2018,01 October 2013,1481409.0 E-FLAG,University of South Paris * Université Paris-Sud,photonics,"The concept is to collect the best researchers on the topic of the interaction of femtosecond laser with glasses for discussion and exchanges. On the other hand, it is to train students and young researchers on one of the most promising new research field which is the 3D local shaping of linear and non linear optical properties in glasses; the knowledge of the expert being shared with the novices. The development of femtosecond laser has prompted the investigation of many nonlinear physical phenomena, such as multiphoton induced reactions, plasma formation and avalanche ionisation in glasses. Today's ultrafast laser systems offer thus a myriad of material interactions such as 3D refractive index change internal patterning, annealing and micromachining but now other properties are aroused like oxydoreduction, chirality, non-reciprocal writing, self-assembled sub-wavelength structures, nanocluster structuration. These interactions exhibit enormous potentialities in the development of a new generation of components for photonics, optical telecommunication and high power laser. No other technique holds such potential for 3D shaping the linear and non-linear optical properties of optical glasses on demand and thus to realize 3D multi-component photonic devices, fabricated in one single step in a variety of transparent materials. All these qualities let us foresee a considerable and innovative development of the femtosecond laser writing technology in glasses. It is obvious that this new technology will be a source of employment in the next 10 years. We can thus predict a need of knowledge exchange and personnel training. Strength of scientific exchanges has thus to be increased in this research area. In the course of this, consistent views can be produced on the fundamental process for fostering new developments. In the same time, we can expect render easier applications already identify but also stimulate the creation of new original devices and new functions.",Exchanges around Femtosecond Laser Applications in Glasses,FP7,07 November 2014,08 November 2010,75600.0 E-GAMES,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"Organic electronic devices, such as organic field-effect transistors (OFETs), are raising an increasing interest for their potential in large area coverage and low cost applications. Also, the use of single molecules as active electronic components offers great prospects for the miniaturization of devices and for their compatibility with biological systems. Within this framework, e-GAMES goals are:","Surface Self-Assembled Molecular Electronic Devices: Logic Gates, Memories and Sensors",FP7,11 June 2019,12 January 2012,0.0 E-GNOSIS,Norwegian University of Science and Technology * Norges Teknisk-Naturvitenskapelige Universitet (NTNU),health,"The aim is to produce a platform technology that combines the price-point and ease-of–use of lateral flow immunoassays with high-sensitivity, quantitative measurements currently requiring capital intensive equipment. This could ultimately allow its use as a consumer-technology, to diagnose and monitor health. e-Gnosis is an interdisciplinary project combining the current state-of-the-art in recessed ring-disk nanoelectrode arrays with a novel signal amplification strategy in the form of ferrocene loaded pH sensitive polymer nanobeads. e-Gnosis will combine these technologies to produce a multiplexed biosensor chip capable of running several ultra-high sensitivity immunoassays without the need for complex or expensive read-out equipment. The use of nanostructured electrode arrays allows the local pH to be changed electrochemically, such that the pH sensitive beads bound to the analyte dissolve and release ferrocene, leading to a large, proportional signal amplification of each binding event. Amplification can be triggered without external reagent addition and, importantly, without necessitating a wash step to remove unbound labels (the rapid initial current peak is bound to originate from within the nanostructures). Performance characteristics will include low sample volume requirement, sensitivity, limit of detection, robustness to interferrents, dynamic range and speed to result. Fabrication is based on highly parallel semiconductor fabrication technology and standard methods for antibody immobilisation, allowing low cost production. The e-Gnosis platform can also be used for other affinity based recognition events. Apart from the potential commercial and societal benefits of such a sensing technology, the project will also produce two enabling methods within nanofabrication and surface functionalisation. The project feeds into key areas identified by EU and industry stakeholders within ETP Nanomedicine and Horizon 2020, amongst others.",e-Gnosis: a novel platform technology for quantitative mobile diagnostics,FP7,30 April 2016,01 May 2014,230943.0 E-STARS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"E-STARS project aims at developing enhanced sensing and communication capability on an autonomous smart micro system powered by a new 3D high capacity integrated micro battery. According to the experts, the market of wireless smart sensors should generate revenues more than 5 billion euro in 2011 (source: http://www.rfidjournal.com). Faced with such future strong technical and economical impact, it is of strategic importance to maintain the Europe¿s leadership in these domains. Considered as an RandD topic of high relevance in such domain (EpoSS Strategic Research Agenda), the energy-management, scavenging and storing techniques aspects will be particularly investigated by the E-STARS project._x000D_ The objective is to reach higher energy-management and autonomy performance packed in a smaller volume. The innovative 3D architectures micro batteries will increase by 5 to 10 the battery capacity (from 100 µAh/cm² to 1 000 µAh/cm²) and power (from 5 mW/cm² to 50 mW/cm²) compared to traditional solutions. To do so, the consortium will investigate completely new deposition processes for micro battery layers such as Chemical Vapor Deposition (CVD), electrospraying and electrodeposition in order to obtain 3D higher aspect ratio aspects. _x000D_ The consortium involves well known complementary research partners (CEA, TUDELFT and UNIVERSITY of PARIS XI), industrial partners (MOTOROLA, STMICROELECTRONICS), as well ad SME¿s (BIOAGE and CORA TINE TEORANTA) from 5 EU countries. _x000D_ As a STREP project, E-STARS addresses clearly the objective 6 of challenge 3 of the ICT call 2 : Micro/nanosystems. The targeted applications within the project are : wearable intelligent micro sensors, wireless networked sensors associated to an intelligent data to internet platform and innovative nanogravimetric sensors and biosensors._x000D_ More globally, thanks to an optimized dissemination of the result, the project will provide the EU industry with new highly autonomous wireless sensors to face the strong competition in this field.",Efficient Smart sysTems with enhAnced eneRgy Storage,FP7,31 May 2011,01 June 2008,2599933.0 E3CAR,Infineon Technologies AG,information and communications technology,"The objective of the project is the development of nanoelectronics technologies, devices, circuits architectures and modules for electrical cars/vehicles and demonstration of these modules in a final systems.",E3Car -> Nanoelectronics for an energy efficient electrical car,FP7,01 January 2012,02 January 2009,0.0 EAGLE,PAN - Institute of Physics * Instytut Fizyk,manufacturing,"The EAgLE project aims at establishing at the Institute of Physics, Polish Academy of Sciences (IFPAN) a leading multiprofile research Centre for designing and fabricating new materials, their characterization and testing under extreme experimental conditions. The Centre will identify and select novel materials, structures, phenomena, and computational protocols for functional new-concept nanodevices.",European Action towards Leading Centre for Innovative Materials,FP7,11 June 2018,06 January 2013,0.0 EASE,Goethe University Frankfurt * Johann Wolfgang Goethe Universität Frankfurt am Main,energy,"The primary aim of this project is to substantially expand the frontiers of current investigations on synthetic polymers for photovoltaic applications by in silico studying new supramolecular assemblies. The main features of efficient natural photosynthetic centres will be used to understand how to improve artificial devices. One of the key issues which this proposal addresses is the inherent difficulty associated with achieving artificial polymers capable of reaching high quantum yield in energy conversion. Up to now it is known that the best performing systems in bulk heterojunctions reach a 5% conversion efficiency; with the actual technology it is estimated that the upper limit is roughly 10%. The present project strives for tackle the barrier of organic solar cell efficiency: to this end state-of-the-art computational techniques will be used to catch the unique features of natural photosynthetic centres which allow for high quantum yield. Recent experimental and theoretical investigations on the Fenna-Matthews-Olson complex have revealed that coherent Quantum Dynamics could be the key to explain its performance in energy conversion. To reproduce coherent dynamics, a regime of intermediate coupling between the exciton and the phonon bath should be attained in the electronic energy transfer process. Such regime has been reached by evolutionary paths in many other natural systems. From the theoretical point of view very little is known about the main features/parameters governing the coherence among chromophores; only recent advances have paved the way to the study of quantum dynamics in supramolecular (natural or artificial) systems. Classical Molecular Dynamics simulations and ab initio calculations will be performed to get an insight on natural systems and to develop a theory relating structural and functional features.",Energy Transfer in Supramolecular Nanostructures,FP7,30 June 2015,01 July 2012,353579.0 ECAMM,European Institute of Molecular Magnetism Scarl,health,"The objective of the proposal is to support the creation of a European structured research area for catalytic and magnetic nanomaterials by integrating two DISs (ERIC and EIMM) operating in the fields of catalysts and nanomagnetism, and their plan to expand current activities in order to (1) obtain a larger coverage of industrial technologies/sectors and (2) extend the involvement to the activities of the relevant industrial partners. The aim is to create a realistic basis to achieve financial sustainability of the two DISs which will keep their own individual personality, but share knowledge and expertise, structure, equipment and other resources, to offer a broader and cost-effective range of services to companies, and in the long-term the vision is to provide new competences (deriving from the integrated collaboration) to new industrial sectors such as materials for nanomedicine, health care and diagnostics, to ICT, environment protection, and nanomaterials' risk. Functional to this objective are also the possibilities a) to realize efficient synergies to reduce the management costs of the DISs, and to be more cost-effective for a structuring effect inside ERA, b) create a larger critical mass, and a broader spectrum of expertise and equipment, c) improve the attractiveness towards young researchers through a combination of high-profile science and educational activities in their favor, and d) enhance the visibility and develop more efficient politics for incorporating new partners in order to progressively expand the actual core partners. Reaching the objectives, implementing these activities will thus result in 1) an improved coordination in both research and innovation, through the management and cultural synergies between the two DISs (ERIC and EIMM); 2) a more robust critical mass of the durable integrated structure; 3) a boosted dynamism of research, technological development and innovation in the field(s); and 4) an improved structuring of the European Research Area.",European structured research area for CAtalytic and Magnetic nanoMaterials,FP7,29 February 2016,01 March 2012,445000.0 ECCELL,Ruhr University Bochum * Ruhr-Universität Bochum,health,"ECCell The aim of the project is to establish a novel basis for future embedded information technology by constructing the first electronically programmable chemical cell. This is naturally a high-risk, embryonic research project, but aimed at a breakthrough which will lay the foundation for immersed micro- and nanoscale molecular information processing with a paradigm shift to digitally programmable chemical systems. Chemical cells must combine self-replication, self-containment and self-regulation of resources (metabolism) enabling evolution to qualify as alive. ECCell will employ novel families of fully synthetic hybrid informational polyelectrolyte copolymers (not simply DNA), which simultaneously support all three cell functionalities. Their microscopic multiphase self-assembly under electric field control is the primary information processing mode of this technology. Realtime digital electric field control sequences, regulating the semi-autonomous self-assembly and reactive molecular processing, will both provide an online programming methodology for these complex systems and potentially serve as electronic genomes for the chemical cells. Programming methodologies (beyond optimal control theory) will be explored and evaluated which deal effectively with the remote real time distributed regulation of these novel semi-autonomous combinatorially complex chemical systems. The research will establish an effective IT interface between microelectronic and molecular information processing, by demonstrating its use to achieve a hard chemical synthetic systems objective (an artificial cell) opening a platform for programming a novel chemical living technology at the microscale.",Electronic Chemical Cell,FP7,31 December 2011,01 September 2008,1999999.0 ECHELLE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"This project concerns New and Advanced Concepts in Renewable Technologies. It is relevant to FP6 objective Research Development and validation of thin -film PV technologies with higher efficiency cost ratio. The field of study is thin film solar cells manufactured by novel low cost methods. It adopts an interdisciplinary approach from two leading European scientific institutions. It is is proposed to increase solar cell efficiency in the II-VI materials field by : - Flexible and quantitative modelling optimisation from a knowledge based perspective based on characterisation on a nanometre scale. This will develop a quantitative understanding of light and dark currents taking materials issues specific to this system into account down to the grain size scale. - Extrapolation of the knowledge to improved designs. These will primarily consist of changes to the band structure of the cell in order to maximise photocurrent, and minimise the trap dominated dark current by manipulating carrier density profiles in the depletion layers. - Increase efficient use of light by using light trapping techniques. In turn these relax requirements on layer thickness required to absorb incident light, and consequently relax the requirements on minority carrier transport. This leads to solar cells more tolerant of imperfect material, of particular interest in polycrystalline material. - Implement innovations in real thin film polycristalline devices (chalcopyrite type) produced by low cost methods (electroplating) in which the host laboratory has a recognized experience.",Electrodeposited Chalcopyrite thin film solar cells: High efficiency Limits and Losses Evaluation,FP6,14 February 2006,15 February 2004,149103.3 ECL NANO-MATERIALS,University of Strathclyde,photonics,"This programme addresses how single molecules such as quantum dots or metal centres within nano-structured polyelectrolytes can be used to create efficient electrochemiluminescent (ECL) sensors multi-analyte detection, specifically for biomedical sensors with ultra-high sensitivities and selectivity's. The unique capabilities of these novel nano-materials will arise from the coupling of photonic, chemical, optical and fouling resistant properties of each component to create a sensitive and selective detection system while allowing for applications in point of care devices. A combination of spectroscopic and electrochemical techniques will be utilised to elucidate the electron and/or energy transfer mechanisms, which will allow optimisation of device performance to be performed. The spectroscopic and electrochemical techniques highlight the redox reactions influencing the ECL production. Tailoring of surface properties and modification of polyelectrolytes will involve the use of several analytical techniques, including atomic force microscopy and electrochemical quartz crystal microbalance analysis. These studies focus on the binding of the polyelectrolyte, which will impart desirable surface chemistries at the material-solution interface to optimise the fouling resistant properties while retaining the sensitivity and selectivity of its ECL production for applications in imaging technologies. These materials will feed into product development which will incorporate sensor design, novel detection platforms and easy to use devices. The development of novel 2nd and 3rd generation materials will focus on the detection of cardiac Troponin I (TNI). The properties of these materials will uniquely enable the development of advanced diagnostic devices based on the luminescent detection of TNI at sufficiently low concentrations so as to change clinical practice.",Development of nano-spheres and quantum dots for electrochemiluminescent (ECL) biomedical diagnostic sensor technologies,FP7,30 September 2014,01 October 2010,100000.0 ECNANOMAN,Carl von Ossietzky University of Oldenburg * Carl von Ossietzky Universität Oldenburg,health,"The project ''European and Chinese Platform for Nano Handling, Assembly and Manufacturing (ECNANOMAN)'' focuses on the staff exchange between the partners of EU and China, and on the development of new nano handling, assembly and manufacturing technologies. It meets the objectives and requirements of the Marie Curie Action: International Research Staff Exchange Scheme (IRSES), by setting up multiple bridges between European and Chinese institutions. The ultimate goal of ECNANOMAN is to establish a long-term research cooperation platform between Europe and China in an emerging field with promising applications in many areas such as nanomedicine, environmental science, nanoelectronics, nanophotonics and manufacturing. The synergistic approach made by ECNANOMAN will keep the consortium's leading position in the world for potential major scientific and technological breakthroughs. The project is divided into five inter-related work packages: (1) Setup of knowledge base and road mapping, (2) Nano handling tools and techniques, (3) Nano assembly and manufacturing, (4) Dissemination and exploitation, and (5) Project management. The workpackages integrate all activities that will lead to the completion of all the project objectives within 36 months.","European and Chinese Platform for Nano Handling, Assembly and Manufacturing",FP7,31 July 2014,01 August 2011,390600.0 ECNP-GROWTH,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),energy,"This proposal addresses the consolidation of the European Centre for Nanostructured Polymers - ECNP - which was established in 2006 by the European Network of Excellence NANOFUN-POLY (FP6 2004-2008) and is currently operating in coordinating research, dissemination and technology transfer activities among its partners. ECNP is focused on the continuation of the four main activities of the NoE: a joint research road map, a joint educational programme, a joint infrastructure and joint technology transfer services in the specific field of multifunctional nanostructured polymers and nanocomposites. So, this support action intends to consolidate ECNP offering a realistic financial plan to expand the current activities by ensuring coverage of industrial technologies research and transfer relevant to the main application sectors addressed by ECNP: Manufacturing (Polymer Nanocomposites), Energy (Flexible Photovoltaics), Healthcare (Biomaterials), and ensuring the extended participation of relevant industrial partners. It is expected that this support action will improve coordination in research and innovation on polymer nanotechnologies and will generate a more robust critical mass of the durable integrated structure of ECNP, leading to a better structuring of the European Research Area.",CONSOLIDATION OF THE EUROPEAN CENTRE FOR NANOSTRUCTURED POLYMERS,FP7,31 January 2015,01 February 2012,444192.0 ECO-GRAPHENE,University of Vienna * Universität Wien,information and communications technology,"Since the discovery of two–dimensional and meta–stable graphene sheets, the recent years have witnessed a dramatic increase in the research dedicated to explore its physical properties. This can be attributed to the two following reasons. First, graphene allows one to address basic questions of quantum mechanics such as relativistic Dirac fermions or the Klein paradoxon in a simple condensed–matter experiment. Second, the nanometer size, the scalability and room–temperature ballistic transport properties make graphene a promising candidate for future nanoelectronic devices with high electronic mobilities and an ideal material for spintronics. In this proposal, the spectroscopic investigation of functionalized mono– and few–layered graphene (FLG) is suggested. The samples are already available as graphene layers grown by precipitation on SiC and by chemical vapour deposition on metal (111) surfaces and as graphite intercalation compounds (GICs), consisting of stacked layers of doped graphene sheets. Their electronic, vibronic and optical properties as a function of functionalization will be investigated by optical spectroscopies, photoemission and electron energy loss. We utilize a combined experimental and theoretical approach in order to gain a deep understanding of graphene physics. Particular emphasis will be paid to electronic correlation effects and how they contribute to the recently discovered exotic properties of graphene. Our multi-disciplinary approach ensures that the results obtained will not only contribute to the fundamental understanding of correlation effects but also yield valuable input for device physics of graphene.",Electronic correlation in pristine and doped graphene layers,FP7,09 June 2014,10 January 2009,45000.0 ECO-SEE,University of Bath,construction,"The ECO-SEE project aims to develop new eco-materials and components for the purpose of creating both healthier and more energy efficient buildings. We will create and symbiotically use natural eco-materials for healthier indoor environments through hygrothermal (heat and moisture) regulation and the removal airborne contaminants through both chemical capture and photocatalysis. Our objectives include advancing state of the art in the technology and application of multifunctional bio-based insulation materials, vapour permeable and hygrothermal and moisture buffering finishes, together with wood panel products, to create both internal partition and external highly insulated wall panels. Novel chemical treatments and processes will be used to enhance volatile organic compound capture capacity of materials. We will also develop highly novel photocatalytic coatings using nanoparticle technology, which will be suitable for use in interior spaces and compatible with lime and wooden surfaces. Novel material development will be completed in partnership with world-class expert organisations in indoor environmental quality. We will also create a new holistic modelling framework that combines air quality, hygrothermal comfort and acoustic quality for the well-being of building users. We will take new products through to proof of concept development with prototype manufacture, large scale tests and pilot studies. We will deliver products with at least 15% lower embodied energy, at least 20% longer life, and, for at least 20% lower build costs. Our consortium brings together a multi-disciplinary team of world-class researchers from universities and research organisations with a number of large enterprises and innovative SMEs, whose combined expertise and capacity will lead commercial development and exploitation of our products. We will engage with stakeholders, including Public and Health authorities and standards committees, and deliver training and technical guidance.","Eco-innovative, Safe and Energy Efficient wall panels and materials for a healthier indoor environment",FP7,08 July 2019,09 January 2013,6550000.0 ECOF,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,energy,"The effective conversion of light into chemical or electrical energy is one of the major challenges of humanity during the 21st century. Organic bulk heterojunctions of polymers or aggregates of small molecules combining donor- and acceptor-functionality offer promising prospects for effective light-induced energy conversion. In order to efficiently utilize the solar energy, interpenetrating networks of donor- and acceptor components are often required. While impressive advances have been achieved in organic photovoltaics systems, so far a deterministic control of their nanoscale morphology has been elusive. It would be a major breakthrough to develop model systems with well-defined periodic, interpenetrating networks of electron donor- and acceptor-phases. It is the goal of this project to create such highly defined model systems, to enhance our understanding of the relationship between the electronic and structural parameters and the resulting light-induced charge carrier dynamics. To pursue this challenge, we base our strategy on the recently discovered conceptual paradigm of Covalent Organic Frameworks (COFs). COFs are a class of highly porous, organic crystalline materials that are held together by covalent bonds between molecular building blocks. In a concerted team effort with organic chemists, we will create COFs with different Ï€-stacked heteroaromatic electron donor- and acceptor moieties, thus forming highly ordered interpenetrating networks for light-induced charge separation. This interdisciplinary program is unique as we join the forces of top-level organic synthesis with advanced nanoscience and in-depth physical characterization in one team.",Electroactive Donor-Acceptor Covalent Organic Frameworks,FP7,28 February 2018,01 March 2013,2431728.0 ECOMAGICS,University of Regensburg * Universität Regensburg,information and communications technology,"In this proposal a new electric field based approach for the control of magnetization dynamics is discussed. The advantage of using electric fields compared to magnetic fields is twofold: (i) electric fields are easy to confine in nano-structures (screening), and (ii) no current flow is required which may allow for the development of new spintronic devices with ultra low power consumption.",Electric Control of Magnetization Dynamics,FP7,12 July 2018,01 January 2012,0.0 ECONANOSORB,"L'Urederra, Fundación para el Desarrollo Tecnológico y Social",environment,"The proposed research project brings together European universities and research centres from Spain, Italy and Germany and three participant institutions from Russian Federation and Ukraine. It builds on existing international projects under the Seventh Framework programme and will enhance the already active collaboration in the field of environmental protection. The main aim of the proposal is to create conditions for mutual research among similarly orientated European research institutions and overcome existing gap between research institution and wood processing industry. The main objectives are: supporting and improving human and research potential, expanding research cooperation in European research area, spreading the output of the research on the both European and international level. Some of the project outputs are exchanging know-how with experienced research entities in Europe, Russia and Ukraine organizing conferences, creating strategic research plan for forest products based sector, improving tools for research results dissemination and online service for forest based industry sector. Increasing production of wood processing industry within Europe, with limited resources of renewable wood raw material, creates needs for more efficient, effective and knowledge based utilization of this raw material. The project consists of the following workpackage Preparation, characterization of nanomaterials from natural and synthetic ionits for adsorption of industrial toxicants; Preparation, characterization and application of combined adsorbents on the base of carbon nanomaterials; Application of nanosorbents for wastewaters and air purification and utilization in nanocomposite materials; Development of a sensor of industrial toxicants and biomedical devices on the base of nanomaterials; Risk and impact assessment related to production and application of nanomaterials in the wood industry as well as Project coordination.",Ecological application of nanosorbents on the base of natural and synthetic ionites and carbons,FP7,04 June 2018,05 January 2012,378100.0 ECOPLAST,Fundación para Promocion Innovacion Investigacion y Desarrollo Tecnologico en la Industria de la Automocion en Galicia,health,"The main objective of the project is the development of new biomass-based composites validated for the automotive industry by means of the adaptation of base biopolymers and the generation of new ones, using innovative treatments for fibre reinforcements and the additivation of the base polymer with novel fillers and nanofillers. The principal research line will be focused on the adaptation of available biopolymers (PLA, PHB) and the creation of a new protein-based biopolymer (SELP) for its use as the base matrix to be able to meet automotive standard requirements. To achieve that advance, it is indispensable to improve the thermal characteristics of these polymers, the hydrolysis resistance, the dimensional stability and the volatile emission. Therefore, this project will develop several new reinforcements and novel additives like nanofillers, mineral fillers and treated natural fibres (nanocellulose) to be compounded with these base polymers in order to create new biocomposites. Accordingly, it will be used: a. Nanofillers to increase the thermal resistance. b. Natural fibres and nanocellulose to enhance the dimensional stability and the mechanical resistance. c. Mineral fillers to reduce the moisture absorbency. Another important goal in this project is the adaptation of conventional processing techniques (polymers compounding, injection moulding and thermoforming), widely used in the automotive industry, and the design of new ones tailored to these biocomposites. The challenge here will be to overcome the problem of degradation because of the extreme thermal conditions and the moisture absorbency.",Research in new biomass-based composites from renewable resources with improved properties for vehicle parts moulding,FP7,31 May 2014,01 June 2010,2820000.0 ECOPOD,Masaryk University * Masarykova Univerzita,health,"Repetitive blocks of guanine- and cytosine-rich sequences, such as those occurring in centromeric and telomeric DNA regions and promoter regions of protein coding genes, have ability to form G- and C-quadruplex structures, respectively. These non-B DNA structures are involved in more than 40 pathological human conditions including cancer. From a biophysical point of view, a common property to both G- and C-rich sequences is their inherent sensitivity to non-specific, physical-chemical environmental factors promoting their conformational polymorphism. Despite significant effort, motivated by both biological significance and biotechnological and biomedical applications of these non-B DNA motifs, the mechanistic nature of the environmentally induced effects remains poorly understood. The mechanistic insight and revealing of relationships between the DNA sequence and its folding topology in relation to its environment is essential for both rational design of novel nanomaterials and ways for their manipulations as well as for related biomedical applications. In this project, we propose systematic investigations of the influence of non-specific physical-chemical factors on structure of the DNA quadruplexes. In parallel, we propose characterization of these structures under the physiological conditions in vivo using state-of-the-art method of in-cell NMR spectroscopy. The acquired information will help to identify physiologically relevant structures of G- and C-quadruplexes.",Environmentally Controlled Polymorphism of non-B DNA structures,FP7,30 September 2016,01 October 2012,100000.0 ECOSAM,Smithers Rapra And Smithers Pira Ltd.,environment,The main objective of the proposed project is to develop a novel surface pre treatment method for chrome plating on a broad range of plastics The majority of industries worldwide use a hexavalent chrome based pre treatment Its major disadvantage is that hexavalent chromium Cr VI is carcinogenic Therefore the chrome plating industry is coming under increasing pressure from EU environmental health and safety legislations and many companies are facing a bleak future unless sustainable and cost effective solutions are discovered The project aims to develop a new process based on a molecular self assembly technology SAM developed at laboratory level in Spain in the manufacture of organic sensors that eliminates the need for chemical etching and electroless nickel plating and which provides a stable and secure surface suitable for subsequent chrome plating operations In line with the general objectives of the EU and FP6 this will achieve the following specific objectives Eliminate carcinogenic chromic acid from the pre treatment process Decrease processing time and the number of plating rinsing tanks Offer greater product flexibility as the process will not be limited to a single polymer such as acrylonitrile butadiene styrene ABS Reduce waste water and chemicals due to fewer process steps Reduce the cost of the plating process due to elimination of the expensive palladium catalyst and electroless nickel coating operations Increase process stability compared to classical wet chemical metallization Maintain the performance whilst lowering the cost of the chrome plating process The anticipated outcome of the project will be an optimised process for electroplating on plastic materials that is both more economical and environmentally friendly compared to the conventional plating process,The development of a novel hexavalent chrome free environmentally sustainable pre treatment for plastic surfaces using molecular self assembly nano technology,FP6,31 December 2008,01 October 2006,545461.32 EDEN,Fondazione Bruno Kessler (FBK),energy,"EDen aims at building a forefront scientific, technological and industrial expertise in energy storage and recovery system. In the past years hydrogen has been indicated as an advantageous energy carrier under many points of view, mainly environment preservation and high energy density. The necessity of hydrogen on specific mobile applications and energy backup system is promoted by the growing demand of sustainable solutions and the interface of discontinuous renewable energies. Hydrogen storage is well known to be the major bottleneck for the use of H2 as energy carrier and despite the huge scientific and industrial effort [fig.1] in developing a novel practical solution for the hydrogen storage, actually there are few storage systems available for nice markets. The request for energy storage systems is growing as fast as the energy availability from renewable sources, consequently the market is demanding for more performing systems, safer and economic. It is emerged from the past EU projects (STORHY, NESSHY, COSY, NANOHY, FLYHY) that the hydrogen storage in solid state is the better solution to seek. Between the materials studied for solid state hydrogen storage, Magnesium based systems represent nowadays the major candidate able to meet the industrial storage targets: they have proper gravimetric and energetic density (typical >7 wt.%, ≥ 100 kg H2/m3) and suitable charging and discharging time and pressure. The main barrier to the wide use of the Magnesium based materials in hydrogen storage system is represented by two limitations: the working temperature of about 300°C and the high heat of reaction, around 10Wh/g. More specifically, EDen project aims to overtake these limitations by developing and realising an efficient hydrogen storage system that brings together available solutions from the market, the results of the EU projects on hydrogen storage and the development of novel solution for the storing material.",High energy density Mg-Based metal hydrides storage system,FP7,30 September 2015,01 October 2012,1524900.0 EDISON-GA,London School of Economics and Political Science,health,"Digital cameras designed with CMOS image sensors are one of the fastest growing sectors of the consumer electronics market. With increasing number of pixels and improving image quality, they have found applications in a range of systems from mobile handsets to space observatories. Despite this growth, they still suffer from limited dynamic range and poor colour discrimination abilities. Furthermore, increasing number of pixels have led to increasing power dissipation in these sensors. This project would train early stage researchers in the design of image sensors utilising optical nanotechnology, in particular plasmonic filters. These filters would help improve the colour response of the next generation of sensors. More importantly, the project would also develop a large format high intensity imager, which would be useful for improved radiotherapy in the treatment of cancer. The network would provide training and research opportunity to ESRs in an academic, industrial as well as clinical environment.",European Doctorate in Image Sensors with Optical Nanotechnology at Glasgow and Awaiba,FP7,31 October 2016,01 November 2012,1467957.0 EDROX,Universiteit Leiden * Leiden University,health,"The goal of the EdRox research training network is to provide advanced and in depth training in bio-nanotechnology to 'early stage researchers' and 'experienced researchers'. The training program is intimately connected with the research program. The latter focuses on the implementation of a novel concept called 'Fluorox' to monitor redox reactions in vivo and in vitro. It allows detection levels that are orders of magnitude lower than provided by conventional electrochemical methods. FluoRox devices monitor chemical compounds at trace levels with applications in medical and environmental monitoring. It also allows miniaturization to the sub-micrometer level, thereby opening up new areas of technological applications. The Fluorox concept involves engineering of existing redox enzymes, linking them to electrodes, and incorporating them into an optical detection scheme. Training and research include instruction in state-of-the-art techniques in biophysics, chemistry, biochemistry and biology and teaching of complementary skills like communication and presentation, research management, handling of intelleectual property (IP), teaching, entrepreneurship, career opportunities in the European Research Area (ERA).",The 'FluoRox' concept; advanced Education and research in Bio-NanoScience,FP6,30 November 2010,01 December 2006,3167244.45 EE-ASI,Cardiff University,health,"Current approaches to improving glycaemic control in type 1 diabetes are centered on increasingly complex insulin delivery systems. However, less than 30% of patients can achieve target levels of glucose control with this approach even in a clinical trial setting and many patients are either unable or unwilling to make the personal commitment required. By contrast, preservation of even small amounts of endogenous insulin production, has been shown to improve glycaemic control, reduce hypoglycaemia, improve quality of life and reduce long-term complications. Importantly, glycemic control in the presence of endogenous beta cell function is not demanding and hence would be effective across the full spectrum of individuals. Antigen specific immunotherapy (ASI) is the preferred approach to beta cell preservation since this avoids the risks of immunosuppression. Attempts at ASI to date although successful in preclinical models have had limited efficacy in humans. There is therefore an urgent need for the development of novel approaches to deliver effective ASI. Our Enhanced Epidermal -Antigen Specific Immunotherapy (EE-ASI) system represents an innovative approach to ASI created by combining technologies brought by our academic and 2 SME partners. A beta cell target T cell epitope (proinsulin C19-A3) will be combined with the tolerogenic cytokine IL-10 and targeted to antigen presenting cells via gold nanoparticles and delivery into the very superficial layers of the skin using microneedles. Validation of manufacture, in vitro and in vivo preclinical efficacy will be demonstrated followed by a phase 1 clinical trial to confirm safety in humans. We anticipate that the EE-ASI system will be less costly, more effective and more acceptable to patients in improving glycaemic control than exogenous insulin replacement. Intellectual property, regulatory and ethical issues will be carefully addressed in order to maximise exploitation of this integrated system for the benefit of the SMEs.",Beta cell preservation via antigen-specific immunotherapy in Type 1 Diabetes: Enhanced Epidermal Antigen Delivery Systems.,FP7,31 August 2016,01 September 2012,5983871.0 EFFIBUILDINGS,University of Lleida * Universitat de Lleida,energy,"The use of phase change materials (PCM) for thermal storage has attracted researchers in all over the world, mainly due to their large energy storage density, which is available within a narrow temperature range. There is unlimited number of possible applications where PCMs can be used such as buildings, glass houses, cold stores, refrigerated trucks and cooling of electronic devices. Work on PCMs has been ongoing for decades but their commercial use is still limited due to their high production and encapsulation costs. The project described in this proposal aims to develop a new technology for the production of PCMs from waste products and also to develop innovate methods of encapsulating these materials so they can be used in these different applications. Also since most of the commercial microencapsulated PCM products have not been fully tested for mechanical strength, a new technique of testing will be applied using for example nano-indentation technique. Prof. Farid has more than 25 years of experience working on PCM production and encapsulation. In PCM application, Farid will introduce his new approach of using PCM in building materials such as timber, using vacuum impregnation. To our knowledge, this has never been applied before and will lead to significant increase in the thermal mass of timber homes used in Northern Europe and other countries. Also based on his New Zealand's expertise in food storage, he will develop a suitable method of encapsulating low temperature PCM for temperature regulation of cold stores and refrigerated trucks, which is important to most European countries. The main objective of the proposal is to host Prof. Farid who will introduce the valuable knowledge of a third country (New Zealand in this case) into Europe. The participation of Prof. Cabeza in Cost Action TU0802 will help to disseminate this knowledge to most groups working with PCM in building applications within Europe.",Thermal energy storage with phase change materials for energy efficiency of European building stock,FP7,25 April 2011,01 June 2010,107027.0 EFFIPRO,University of Oslo * Universitetet i Oslo,energy,"EFFIPRO will develop electrolytes and electrodes for proton conducting fuel cells (PCFCs) based on novel LaNbO4-type and similar proton conducting oxides that, unlike earlier candidates, are chemically stable and mechanically robust. The transport of H+ makes water form on the cathode side, avoiding fuel dilution and recycling and reducing risk of destructive anode oxidation, even at peak power. Moreover, the high operating temperature (e.g. 600 °C) alleviates recycling of liquid water and coolants, and provides efficient heat exchange with heat grids or fossil fuel reformers. All these give PCFCs major benefits in fuel utilisation, overall efficiency, and system simplicity with reformed fossil fuels as well as hydrogen from renewables. However, the proton conductivities of candidate materials are insufficient, and the project aims to improve proton conductivity through doping strategies and interface engineering, investigating new classes of stable proton conducting oxides, and developing technologies for thin film electrolytes on suitable substrates. Novel cathodes will be devised, all to bring area-specific electrolyte and interface resistances down to 0.2 Ωcm2 each within this first project. New production routes of precursors and materials are included, as well as surface kinetics research and cost reduction by mischmetal strategies. The project is accompanied by complementary national initiatives and projects e.g. on fundamental characterisation and interconnects. Novel PCFC technology involves high risk and long term research that needs concerted action from many actors including the emerging nano-ionics field. It is the aim that PCFCs by 2020 will be available, accelerate the use of fuel cells, reduce CO2 emissions, and increase efficiency by 10 % where applied, promote the hydrogen society, and be a dominating fuel cell technology. The project counts 7 partners in 5 countries, with leadership and PCFC dedication. It lasts 3 years and educates/trains 5 PhD/post-docs.",Efficient and robust fuel cell with novel ceramic proton conducting electrolyte,FP7,30 April 2012,01 May 2009,2540258.0 EFSUPS,Wissenschaftsladen Bonn eV,information and communications technology,"The EFSUPS proposal aims at the development of further vocational training for child minder and teachers at primary schools. This project will identify and evaluate existing information and already available training material to foster scientific understanding in kindergartens and primary schools based on the education for a sustainable development (ESD). It will focus on 'soil' issues. EFSUPS intends to develop the cur-riculum, simple experiments and practical offers for nature experience. The EFSUPS project will consider gender-fair didactics. This applies also to the development of gender specific teaching material and experiments. With the development of the teaching materials explicit attention will be paid to avoid reproducing stereotypes. Training seminars for teachers and child minders will be included as well as a compilation and the supply of the necessary materials, devices and aids for soil examinations, planting and animal ob-servations and experiments. By the means of the prepared material, teachers guide and toolbox the experiments can be converted in every school garden or school green and, in addition, in a close natural environment of the school or kindergarten. The developed teachers' guide will be translated in English, German, French, Spanish, Romanian and Hungarian and made available by a website. The core dissemination of project results will be accompanied by the 'Eurokids - the Ground Explorers', a working group formed by pupils from participating kindergartens and primary schools, exchanging their experiences in small articles, photo series or videos. The exchange of information on a school and pupil level gives the European dimension of soil problems an education oriented platform and fosters multidisciplinary and inter-cultural competences. Three national workshops - one in each participating country - support the dissemination of the results.",Exploring the Ground - Fostering Scientific Understanding in Primary Schools,FP6,31 October 2008,01 November 2006,226986.0 EHD ATOMIZATION,Rovira i Virgili University * Universitat Rovira i Virgili,manufacturing,"We consider methods of liquid atomization for use in the generation of mono-sized nanoparticles via evaporation
of solvent from liquid droplets (as in spray-pyrolysis or spray-drying). Making nanoparticles with mean geometric
diameter between 1 & 15 nm, requires droplets that are not much larger, in order to reduce trace contamination
in the final residue. Also, nanosize-related effects demand tight control over the width of the droplet size
distribution. We thus consider the generation of drops 5 to 50 nm in diameter, via electrohydrodynamic
atomization (EHDA) as a basis for development of future sucessful atomization methods. This remarkable
technique leads to very narrow droplet size distributions, with means tunable between 100's of microns down to
atomic dimensions (as in liquid metal ion sources). It is also a very gentle technique (routinely used for protein
analysis for example), compatible with many chemistries. Applying this technique, however, requires solving the
constraints of its traditional implementation, the "cone-jet mode", of: (1) high electrical conductivity values, and
(2) low liquid flow rates per emitting point. While the importance of (2) will be dependent on applications, solving
(1) is of fundamental value for enabling such applications.
We propose that recently-reported EHDA modes of "nanospray" and "corona-assisted electrospray" offer new
angles that are worth investigating in this context. While the mechanisms behind each of these modes are still
unknown, these modes appear to be superior to the traditional "cone-jet" mode, especially in regards to the
challenge posed by (1). Understanding their mechanisms will be key to gaining insight about what is ultimately
required to fix problem (1), and is thus one of our main objectives. Another objective is to determine how new
implementations of these modes, by combination, or via coupling of other forms of energy (such a",Electrohydrodynamic atomization methods for the generation of nanoparticles,FP6,30 September 2006,01 October 2004,77400.0 ELAB4LIFE,Universiteit Twente * Twente University,health,"We propose the development of new electrochemical techniques for health and life sciences applications in Lab-on-a-Chip devices. A Scanning ElectroChemical Microscope (SECM) will be used to study surface properties, such as local consumption and/or release of electroactive chemical compounds by (single) cells by electrochemical sensing, new detection methods for proteins using redox cycling, and new separation methods for DNA exploiting nanoscale electrical field gradients. The ability to generate and control electrical fields (and gradients) at the scale of the size of biomolecules using nanostructures, and the simple translation of novel electrical methods into practical Lab-on-a-Chip devices will create a breakthrough in bioanalytical methods. The knowledge and expertise obtained from SECM experimentation will be used to design and realize Labs-on-a-Chip that can be used for efficient production of drugs by electrofused cells, for early biomarker detection using nanowires and nano-spaced electrodes (Point-of-Care application), and rapid DNA analysis using nanofluidic structures. Besides this, the results can have great benefits for study of embryonic cell growth and for advanced tissue engineering. The results will be translated into devices and systems that can be used in Point-of-Care (POC) applications and will bring this area a big step closer to successful commercialization.",eLab4Life: Electr(ochem)ical Labs-on-a-Chip for Life Sciences,FP7,31 October 2013,01 December 2008,2382442.0 ELCAMI,University of Bern * Universität Bern,energy,"Low-temperapture polymer electrolyte membran fuel cells (LT-PEMFC) have been attracting great attention as a promising clean power generator. The primary reaction taking place at the cathode is the oxygen reduction reaction (ORR), which is traditionally catalysed by platinum. Commercialisation of the technology requires lower price, lower overpotential and higher stability of the electro-catalyst. The present proposal aims at exploring structure-reactivity correlations of four types of Pd-based model catalyst as base platforms for a rational ORR electro-catalyst design: (1) high and low index Pt(hkl) and Pd(hkl) single crystals; (2) Pt and mixed Pt-M (M= Fe, Co, Ni) films on Pd(hkl); (3) tailored Pt and Au nanoparticles on Pd(hkl); and (4) palladium-platinum alloy electrodes PdxPty of various composition and crystal orientation. Electrochemical reactivity studies will be combined with novel state-of-the-art in-situ imaging and spectroscopic techniques for monitoring local structure and reactivity. In particular, the applicant will employ in-situ Conductive-Probe Atomic Force Microscopy (CP-AFM) and the novel Raman spectroscopic technique SHINERS, capable for probing processes on well-definded single crystal surfaces under electrochemical operating conditions. This approach allows to explore in-situ the role of adsorbed intermediates as wll as spectators, such as OHads, anions, formation of surface oxides, and will provide unprecedented fundamantal knowledge on basic reaction mechanisms at nanoscale. The experimental work at Bern University will benefit from complementary DFT-type model calculations (collaboration with T. Jacob), and joined application studies with the technology-driven Electrochemistry Laboratory at PSI. The project also aims to build a strong connection of people, knowledge and skills between Europe and Japan for future collaboration.",Electrocatalysis on Model Interfaces,FP7,30 April 2013,01 May 2011,187028.0 ELECTRA,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"Electrostatic Discharge (ESD) is known to be one of the main causes for failures in ULSI technologies. These failures are caused by the discharge of electrostatic charge present either on an external body, like humans or machines, or on the device itself. In order to cope with this problem, ESD protection circuits have to be provided at all input, output and power supply pins, to ensure that the discharge currents are safely conducted towards the ground.With the ever continuing scaling of CMOS technologies, the problem of ESD becomes more and more difficult to cope with. This makes the scaled down technologies more vulnerable to ESD discharges with each new technology generation. Moreover, new materials and technology modules are continuously introduced in future technologies: high k dielectrics and metal gates to replace the conventional SiO2/polySi gate stacks, copper interconnects and low k dielectrics to replace the conventional Al/oxide based interconnect schemes, and new types of devices such as FinFets are under study to cope with the scaling problems of conventional MOSFET and apos;s. The impact of these new modules and materials on the ESD robustness of the devices is unknown and needs to be investigated.The ESD protection of RF CMOS circuits also poses severe problems. The reason for this is that the conventional ESD protection elements cannot be used anymore due to the too high parasitics of the protection elements. As a result new devices and/or design approaches to provide ESD protection for RF-CMOS applications are urgently necessary.In this project these important reliability issues for future technologies will be studied. The impact of advanced CMOS process modules, novel SOI-based devices and advanced junctions on the ESD performance of more or less conventional ESD protection devices will be studied in great detail. New ESD protection strategies and design methodologies for RF CMOS circuits will be investigated and developed.",Electrostatic Discharge Protection for Emerging CMOS Technologies and RF Applications,FP6,30 September 2006,01 October 2004,144588.0 ELECTRICAL,Fundación Tecnalia Research & Innovation,transport,"Aircraft structures appear to be strategic components to be manufactured in composite materials for reducing weight, although new questions regarding electrical conductivity have arisen such as static discharge, electrical bonding and grounding, interference shielding and current return through the structure.",NOVEL AERONAUTICAL MULTIFUNCTIONAL COMPOSITE STRUCTURES WITH BULK ELECTRICAL CONDUCTIVITY AND SELF-SENSING CAPABILITIES,FP7,06 June 2016,10 January 2010,0.0 ELECTROACROSS,Faculty of Sciences and Technology of the New University of Lisbon * Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa,environment,"The socio-economic activities due to world development are promoting increasing pressures on land, creating competition and conflicts, resulting in suboptimal use of resources. Integrated planning and management of land resources is a top subject of Agenda 21 (managed by FAO), which deals with the cross-sectoral aspects of decision-making for the sustainable use and development of natural resources. This is essential for life-support systems and its productive capacity. In this context, there is a need to find new strategies for sustainable development that links social and economic progress with environmental protection and enhancement. Electrokinetic transport processes (EK) uses a low-level direct current as the “cleaning agent”. EK has been applied to the remediation of polluted soils and other contaminated matrices. It also shows a great potential to be used in different fields, as in saline soil restoration, nutrients recovery from wastes or repair and maintenance of building structures. EK may be an integrated approach for new strategies aiming at sustainable development and to support waste strategies, with worldwide interest. EK can also be coupled with phytoremediation and integrated with nanotechnology, enlarging the scope of its application. The conciliation of the EK in the recovery of secondary resources, remediation and conservation is a multidisciplinary novel approach that opens new technical possibilities for waste minimization, through upgrading of particulate waste products and the recover of secondary resources for industrial, agricultural or social use. This objective is achieved through knowledge transfer activities, among a network of European and other continents centres of excellence, consolidating an European School of Electrokinetics. Joint new research on fundamentals and applied EK and its optimization will develop new strategies for sustainable development and the solutions achieved will result in a social-economic impact.",Electrokinetics across disciplines and continents: an integrated approach to finding new strategies to sustainable development,FP7,02 April 2017,03 January 2011,370900.0 ELECTROCHEMBOTS,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),photonics,"The ability to generate electric fields at small scales is becoming increasingly important in many fields of research including plasmonics-based sensing, micro- and nanofabrication, microfluidics and spintronics. The localized generation of electrical fields at extremely small scales has the potential to revolutionize conventional methods of electrically stimulating cells. The objective of this proposal is the development of miniaturized untethered devices capable of delivering electric currents to cells for the stimulation of their vital functions. To this end, we propose the construction of micro- and nanoscale magnetoelectric structures that can be triggered using external magnetic fields. These small devices will consist of composite hybrid structures containing piezoelectric and magnetostrictive layers. By applying an oscillating magnetic field in the presence of a DC bias field, the magnetostrictive element will deform, thereby generating stress in a piezoelectric shell, which in turn will become electrically polarized. Small devices capable of wirelessly generating electric fields offer an innovative way of studying the electrical and electrochemical stimulation of cells. For example, by concentrating electric fields at specific locations in a cell, the behavior of protein membrane components such as cell adhesion molecules or transport proteins can be altered to modulate the stiction of proliferating cells or ion channel gating kinetics.",MAGNETOELECTRIC CHEMONANOROBOTICS FOR CHEMICAL AND BIOMEDICAL APPLICATIONS,FP7,31 August 2018,01 September 2013,1491701.0 ELECTROGRAPH,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,energy,"For vehicle applications, it is desirable to have devices with high energy density, high power density, long cycle and shelf life, and low cost. Supercapacitors are considered one of the newest innovations in the field of electrical energy storage. In hybrid electric vehicle, supercapacitors can be coupled with fuel cells or batteries to deliver the high power needed during acceleration as well as to recover the available energy during regenerative braking. To design a supercapacitor for a specific application that requires high energy density or high power density or both, proper electrode materials and a suitable electrolyte are to be chosen. The combination of graphene and graphene-based material as electrode materials, and the use of room temperature ionic liquids (RTILs) may exhibit excellent performance in supercapacitors. Graphene based materials can be obtained by a bottom-up approach in a more controllable fashion. The enhanced capacitive behaviour of this material may be obtained by the proper alignment of graphene sheets as well as the interconnected nanoscale channels. However, these studies are still at the primary stage, and further studies are necessary. The ElectroGraph project follows a technology driven approach. It is thus obvious that the development of both electrode materials as well as the electrolyte solutions is required in order to optimize the overall performance of the supercapacitor. The main novelty of the technical development is the optimised production of graphene with its properties specifically defined and adjusted for application as electrode material in energy storage devices. This would be achieved through defining of processing parameters to tailor-made graphene with a specific surface area, size and corresponding electrical properties is a new consideration. The ElectroGraph will use an integrated approach in development of both electrode materials as well as the electrolyte solutions as required for optimising the overall performance of supercapacitors.",Graphene-based Electrodes for Application in Supercapacitors,FP7,31 May 2014,01 June 2011,3584077.0 ELECTROHYPEM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"The overall objective of the ELECTROHYPEM project is to develop cost-effective components for proton conducting membrane electrolysers with enhanced activity and stability in order to reduce stack and system costs and to improve efficiency, performance and durability. The focus of the project is concerning mainly with low-cost electrocatalysts and membrane development. The project is addressing the validation of these materials in a PEM electrolyser (1 Nm3 H2/h) for residential applications in the presence of renewable power sources. The aim is to contribute to the road-map addressing the achievement of a wide scale decentralised hydrogen production infrastructure. Polymer electrolytes developed in the project concern with novel chemically stabilised ionomers and sulphonated PBI or polysulfone hydrocarbon membranes, as well as their composites with inorganic fillers, characterised by high conductivity and better resistance than conventional Nafion membranes to H2-O2 cross-over and mechanical degradation under high pressure operation. Low noble-metal loading nanosized mixed-oxides (IrRuMOx) oxygen evolution electrocatalysts, highly dispersed on high surface area conductive doped-oxide (TiNbOx, TiTaOx, SnSbOx) or sub-oxides (Ti4O7-like ) will be developed together with novel supported non-precious oxygen evolution electrocatalysts prepared by electrospinning. After appropriate screening of active materials (supports, catalyst, membranes, ionomers) and non-active stack hardware (bipolar plates, coatings) in single cell and short stack, these components will be validated in a PEM electrolyser prototype operating at high pressure in a wide temperature range. The stack will be integrated in a system and assessed in terms of durability under steady-state operating conditions as well as in the presence of current profiles simulating intermittent conditions.",Enhanced performance and cost-effective materials for long-term operation of PEM water electrolysers coupled to renewable power sources,FP7,30 June 2015,01 July 2012,1352771.0 ELECTRON CORRELATION,University of the Basque Country * Universidad del País Vasco / Euskal Herriko Unibertsitatea,information and communications technology,Graphene nanoribbons are derivates of graphene. Since its discovery in 2004 by Andre K. Geim and Konstantin S. Novoselov it has received enormous attention earning its discoverers the 2010 nobel prize. The great interest in graphene originates in its unique properties.,Electron Correlation - The Electronic Ground State of Graphene Nanoribbons,FP7,04 June 2017,05 January 2013,0.0 ELECTRONIC-LIQUIDS,University College London,photonics,"The scientific aim of this Fellowship is to investigate a novel class of complex fluids in which high concentrations of electrons are present as stable solvated species: so-called \\andquot;electronic liquids\\andquot;. These liquids are typically formed when a metal, such as sodium, is dissolved in ammonia. Such solutions contain a fascinating variety of solvated ionic and electronic species, including isolated polarons, spin-paired bipolarons, excitonic atoms, metal anions, and truly delocalised (itinerant) electrons. These species in turn give rise to remarkable bulk properties. For example; the time-honoured metal-nonmetal (M-NM) transition, liquid-liquid phase separation, very low density, deep pseudoeutectic (giving the lowest temperature liquid metals), high electrical conductivity, and highly aggressive redox reactivity. Technologically, the solutions are promoted as a reducing agent for toxic waste and chemical weapon disposal, as a catalyst for forming high-Tc fulleride superconductors, and as an advanced electrolyte for battery systems. The Host Institution has recently led great progress in our understanding of bulk electronic liquids. The primary aim of this Fellowship is to investigate the detailed structure and dynamics of these solutions in confined geometries, for example intercalated into graphite, and as a solvent for carbon nanostructures, such as fullerides and nanotubes. The project will be multidisciplinary, and will provide the Fellow with training in a variety of techniques and materials that are complementary to her current expertise. Neutron and X-ray scattering will be used to measure the atomic structure and dynamics, while the electronic properties will be probed via conductivity and magnetic resonance. Complementary computer simulation will be used to lead and interpret the experimental programme. The Fellow will be part of an Internationally leading Condensed Matter and Materials Physics Group, which occupies purpose #","Electronic liquids: glass formation, confinement and nanostructures.",FP6,31 October 2005,01 November 2003,159613.0 ELECTROPEP,University of Liverpool,health,"Biomolecules have material and electrical properties which should not be overlooked when considering the design of future generations of electronic devices. We recognise that biomolecules hold substantial promise in electronics; however, success within this field will require the development of new discipline crossing competences. The aim of this proposal is to develop a new design strategy for the formation of molecular electronics devices relying on bio-molecular chemistry rather than traditional chemical synthetic methods. This will be achieved with the use of self-organized peptide monolayers, which will be electrically contacted at both ends. The originality of the project lies in the use of peptides to form a dense and stable monolayer, with the choice from a potentially huge library of analogues that can be readily synthesised. The peptide sequence will be chosen to confer electronic asymmetry to the molecule and also to introduce charged or active functional groups, aiming at current rectification and switching effects. The work will be underpinned by state-of-the-art scanning probe microscopy that allows measurement of the electrical behaviour of single peptide molecules. At Liverpool we have internationally leading research activities in molecular and nanoscale electronics. In particular we have recently developed techniques which enable electrical properties of molecules to be recorded down to the single molecule level. Although we are strong in nano-scale and single molecule electronics we lack personnel with experience in synthetic and measurements aspects of biomolecular electronics. The appointment of two fellows with these specialities will enable us to develop a new area of expertise in biomolecular electronics. The transferred knowledge will enable us to establish ourselves as an internationally leading centre in biomolecular electronics which will certainly lead to future Framework opportunities and collaborations across Europe.",Electronic Devises from Peptides,FP6,30 June 2008,01 March 2006,349232.99 ELEGANT,University of Southampton,photonics,"The Project aims comprehensive experimental and theoretical studies of interaction of ultrashort laser pulses with optical glasses in order to reveal mechanisms of formation of extraordinary structures induced by laser radiation inside the bulk glass and to establish principles of controlled generation of desired glass modifications for applications in photonic devices. Optical glasses have become the key materials of optoelectronics and photonics applications due to their relatively low costs, processability, and possibility to govern refractive indexes. Recent research has shown that, applying femtosecond laser pulses to glass materials, one can create three-dimensional patterns with nano-scale features whose origin has not yet been understood. These findings can open new opportunities for a broad variety of microsystems with nanofeatures. However, further development of laser-writing techniques for controllable generation of desired modifications in transparent materials is impossible without deep understanding of the governing mechanisms of laser-driven material transformations. The Project will overcome the gap between the striking experimental findings of laser-induced glass modifications and theory which is still unable to explain a number of laser-created extraordinary structures. The objectives of this multidisciplinary project are (1) to disclose the nature of formation of volume nanogratings in fused silica; (2) to find mechanisms responsible for anisotropy of direct writing of optical elements dependent on the direction of laser beam scanning; (3) to describe bubble chains formation in glasses, and (4) to develop a concept of laser-induced modification diagrams for transparent materials. Its real outcome will be in making an important step from a primitive concept of simple energy deposition on laser processing of materials toward understanding and more sophisticated description of overall phenomenon of laser-matter interaction.",Extraordinary Laser-induced Excitations in Glasses: Analysis and Theory,FP7,09 October 2013,10 October 2011,264436.0 ELENA,SAV - Institute of Chemistry * Chemický ústav,health,"Glycomics is currently one of the most progressively evolving scientific fields due to ever growing evidence glycans (sugars) are involved in many aspects of cell physiology and pathology. Glycans are information-rich molecules responsible for sophisticated storage and coding 'commands' the cell has to perform to stay 'fit' and to deal with uninvited pathogens. Thus, it is very important the 'glycocode' is correctly deciphered by the cell to stay healthy, but pathogens developed nasty tricks how to crack the 'glycocode' to their benefit by stealing glycan identity of the host to stay unrecognised until it is too late. A better understanding of these processes can help to develop new, potent and nature-based vaccines and drugs. Glycomics stayed behind advances in genomics and proteomics, but due to advent of high-throughput biochips glycomics is catching up very quickly. Two biochip formats available to study challenging and complex field of glycomics are either based on immobilised glycans (glycan biochips) or glycan recognising molecules -lectins (lectin biochips). Both technologies proved to be a success story to reveal amazing, precisely tuned 'glycocode' reading, but so far biochips do not work under conditions resembling natural process of glycan deciphering. The aim of the project is to develop biochips for fundamental study of the effect of precisely tuned ligand (glycan and lectin) density, presence of mixed glycans and the length of glycans on the glycan biorecognition. This task will be executed with the aid of nanotechnology to control these aspects at the nanoscale. Moreover, novel label-free electrochemical detection strategies will be used to mimic natural glycan recognition performing without any label. Finally, advanced patterning protocols and novel detection platforms will be integrated to develop fully robust biochips for functional assay of samples from people having some disease with a search for a particular biomarker of the disease.",Electrochemical LEctin and glycan biochips integrated with NAnostructures,FP7,31 December 2017,01 January 2013,1155970.0 ELEPHANT,London School of Economics and Political Science,health,"Superconductors' remarkable ability to carry significant currents and generate strong magnetic fields is finding use in numerous applications, including energy storage and distribution, medicine, electronics, and transportation. The ground-breaking discoveries of superconductivity in magnesium diboride and iron pnictides have triggered a new wave of fundamental and applied research. In this context, the development of innovative computational methods is an important research direction that will give further insights into the physics of superconductivity and may allow the design of new materials with tailored superconducting properties. I will investigate the role of spatial anisotropy in appealing phonon-mediated superconducting materials by developing and applying cutting-edge atomistic simulation methods. My main goal is to integrate a recently proposed methodology for the electron-phonon interaction based on Wannier functions with the anisotropic Migdal-Eliashberg formalism. The approach holds great promise for qualitatively better description of low-dimensional superconductors, in which the anisotropy of the electron-phonon interaction plays a crucial role, and for enabling the investigation of complex systems, which are beyond the reach of present computational methods. The application part will be devoted to exploring the superconducting mechanisms in carbon- and boron-based materials of reduced dimensionality. Graphite intercalation compounds are still a subject of debate due to the anisotropic nature of the electron paring while carbon nanotubes pose a largely unexplored fundamental question of how superconductivity can emerge in one-dimensional systems. Finally, magnesium diboride remains to be the most outstanding phonon-mediated superconductor despite an extensive search for related superconducting materials: a systematic screening will be carried out to identify multi-component metal boride materials with potential for superconductivity.",First-principles modelling of electron-phonon anisotropy (ELE-PH-ANT) in low-dimensional superconductors,FP7,31 December 2012,01 January 2011,181103.0 ELETRONANOMAT,Technical University of Denmark * Danmarks Tekniske Universitet,information and communications technology,"ELECTRONANOMAT offers major efforts towards establishing and developing a new joint European/Chinese network in comprehensive frontline electrochemical and biological surface science. The network will be a platform for future collaboration based on extensive staff exchange and knowledge transfer among the partner institutions. “Molecular and biomolecular electrochemistry at non-traditional electrode surfaces” is a core notion, rooted in designed electrocatalytic materials with new and interesting properties. The materials are metallic and semiconductor nanoparticle, graphene, and photo-active composite materials, as well as ionic liquid media, prepared by tailored chemical synthesis and characterised to nanoscale and single-atom/molecule resolution by sophisticated physical techniques. The new materials are the basis for multifarious, coordinated efforts in precisely defined joint projects in molecular and biomolecular electrochemistry, single-molecule scanning probe studies, photo-electrocatalysis, and nanomaterial/(bio)molecular hybrids, accompanied by strong theoretical support. Core achievements will include detailed understanding of electronic and transport properties of single “smart” molecules (transition metal complexes, redox metalloproteins) in novel environments, and electrochemical mapping of electronic properties of the new materials alone and in combination with “smart” (bio)molecules. Development of next generation ultra-sensitive chemical and bioelectrochemical sensor devices based on the novel interdisplinary surface science is also offered by the European/Chinese collaboration. The eight strong Chinese and European groups offer all complementary expertise in chemical synthesis, surface characterization, electrochemistry, scanning probe technology, and theoretical expertise needed for the proposed coordinated effort. In return the project will lift molecular and biomolecular electrochemistry and surface science to a new European/Chinese-based level.",Molecular Scale Electrochemistry and Nontraditional Electrochemical Materials Science,FP7,12 July 2017,01 January 2013,287700.0 ELIOT,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,energy,"Two of the main drivers of worldwide economic growth and scientific development are the semiconductor/IC industry and the need for new energy resources. The need for alternate renewable sources of energy such as sunlight and wind power which are inherently discontinuous, poses new challenges for energy transport and storage. Although many of the materials used in the IC industry and in energy storage are similar, the research in their properties has been separated in two fields with very little interdisciplinary interaction. This proposal aims to cross this barrier and evaluate physical and electrical properties of transition metal oxides in their nanostructured form for non-volatile memory and energy storage applications. For this we will investigate how material production and physical properties influence electronic and ionic transport properties in these oxides. We propose to evaluate transition metal oxides, starting with simple binary oxides such as vanadium oxides and assess how material production and physical properties influence electrical and/or ionic transport properties. A first objective is to identify materials where resistive switching can be ascribed to correlated electron effects rather than oxygen or oxygen vacancy rearrangement. It is interesting to determine how these effects are influenced by size and confinement. This is done keeping in mind possible applications as switch/ memory elements. Some oxides are expected to show relatively high ionic mobility making them good candidates for alternate battery materials. For this, screening of ionic mobility of the intrinsic oxide and of Li in the oxide is to be investigated. Correlating oxygen mobility in the lattice with Li mobility can help better engineer materials for highly performing batteries.",Electronic and Ionic Transport in Functional Oxides,FP7,30 September 2014,01 October 2010,100000.0 ELISHA,University of Leeds,health,"Molecular events occurring at the nanoscale impact on the macroscopic level in many different areas and rules for controlled manufacture at the nanoscale are important to understand. The ELISHA project is designed to improve knowledge in molecular interfaces and enable manufacture of new sensors, by interrogating the formation and signal generation of antibodies and electroconductive surfaces. The project is based on: 1) a proven series of experimental observations that antibody loaded electroconductive matrices give concentration dependant responses when interrogated with DC pulsed and AC impedance electronics and 2) the knowledge and belief that the project will bring breakthroughs in nanoscale interfacial electrochemistry, leading to novel generic platforms for electro-interfaced-immunosensors to be produced and commercialised. This is the primary objective of the NMP workprogramme, 'to promote real breakthroughs, based on scientific and technical excellence'. The project targets several priority areas in nanotechnology, NMP-2002-3.4.1.2.1.'the interface between biological and non-biological entities' and NMP-2002-3.4.4.3 - 'New generations of sensors, actuators and systems for safety and security of people and environment'. Novel materials are expected, NMP-2002- 3.4.2.3.1 . and the project is directly in the area of nanobiotechnology, NMP-1.2. The project goes beyond the 'state of the art' in many areas and will give significant strategic impact for the EU, addressing community societal objectives by producing new methods to rapidly detect 1) cancer markers, 2) fluoroquinolines antibiotics and 3) prion type peptides, enabling rapid and point of care detection. The project is structured into 9 workpackages including antibody production, sensor fabrication, immobilisation methods, signal generation and electronics production. A prototype instrument is the material deliverable. A world class team of 9 partners has been brought together to make ELISHA a reality'",Electronic Immuno-Interfaces and Surface Nanobiotechnology: A Heterodoxical Approach.,FP6,30 June 2007,01 January 2004,2452455.0 ELISSA,National Technical University of Athens,information and communications technology,"ELISSA targets the development and demonstration of nano-enhanced prefabricated lightweight steel skeleton/dry wall systems with improved thermal, vibration/seismic and fire performance, resulting from the inherent thermal, damping and fire spread prevention properties of carefully preselected inorganic nanomaterials (aerogels, VIPs, MMTs, CNT) and NEMS as well as the development of industrially friendly methods for their application. New computational and design tools for energy efficient, safe and sustainable anti-seismic steel frame lightweight buildings, exploiting nanomaterials and fulfilling relevant EU building codes, will be developed. The new ELISSA prefabricated lightweight elements will reach the highest achievable degree of energy efficiency, safety - will be structurally tested and optimized as load bearing elements - and sustainability for steel lightweight buildings through:",Energy Efficient LIghtweight-Sustainable-SAfe-Steel Construction,FP7,08 July 2018,09 January 2013,0.0 ELMAGNANO,Queen's University Belfast,information and communications technology,"Magnetoelectric (ME) multiferroics (MF) are prospective constituents for applications in micro- and nanoelectronics. Offering the possibility to switch magnetization (M) by electric field, their utilization would improve device performances. Though, at the state of the art several conditions hamper consideration for actual applications: mesoscopic devices with planar geometry, high WRITE voltages, non-unambiguously differentiable M states.",Electric field driven Magnetization switching in multiferroic Nanoislands,FP7,04 June 2018,05 January 2014,0.0 ELSI,University of Cambridge,energy,"The goal of this project is to create new electrochemical methods of silicon layer formation in fused salt electrolytes in the range of thicknesses from nanometres to micrometres. The research aims to achieve results of high technological significance -formation of silicon thin films for photovoltaic applications (e.g. solar cells). The advantages of the proposed electrochemical SiO2 deoxidation include: 1) possibility to use electrons as absolutely clean agents instead of toxic volatile chemicals used in classical processes; 2) energy efficiency; 3) spatial control of the silicon formation from pinpoint to complete layer, which will open new possibilities for microelectromechanical systems and silicon chip technologies; 4) control of the composition, morphology, structure and crystallinity of the layers depending on the operating conditions. Socio-economic reasons of the project stem from the imperative to search for effective substitutes of fossil energy. Solar energy can be converted to electricity with no impact on the environment and the fuel is free. However, so far, solar energy is expensive. The major part of its costs is related to materials, mainly silicon, which is the most widely used material for manufacture of solar elements. The classical processes of silicon production are highly energy consuming, low efficiency and unfriendly to the environment. The project proposes a new advantageous methods, which offer an opportunity to avoid the drawbacks of classical processes. The research results will be important to major European solar electricity programmes.",Electrochemical Silicon Layers Formation in Fused Salts,FP7,30 September 2011,01 October 2009,246983.0 EMAC,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"MRAM is the candidate of choice for the universal semiconductor memory, offering low power consumption, high speed, high density and permanent storage. The current state of the art is based on Back-End Module (BEM), where the MRAM module is inserted at the end of the process, using multiple layers onto a CMOS substrate. But this technology presents some drawbacks that limit its possibilities, its market penetration and its implementation in nano-scale devices. EMAC project will introduce a decisive breakthrough in MRAM technologies by exploring a non conventional technological approach using a Front End Magnetic Module (FEM) integrated at the CMOS level. The challenge in FEM approach is the integration of magnetic material within an industrial front-end process. The purpose of the project is therefore to investigate enabling technologies for the manufacture of advanced CMOS devices using front-end embedded magnetic materials, from 0.25�m 4kbits memory prototype towards sub-90nm technologies. The EMAC consortium gathers a high transnational network of 9 industrial partners, institutes and universities located in 4 member states that will joint their expertise to work at the frontier of the knowledge. The overall tasks of the project can be roughly divided into three groups: The first group concerns the technological problems: EMAC will explore different methods of oxide and ferromagnetic metal deposition and the subsequent cleaning of wafers after deposition of ferromagnetic metals. The second group of concerns the characterization of fabricated layers and stacks: the routine characterization of fabricated layers and structures will be carried out in each laboratory. The third group of tasks covers the problems of process flow definition, layout, design and test of device: The layout and design tasks, work on silicon processing and pre-patterned wafers with trenches for growth of FEM magnetic module, final metallization and interconnections.",Embedded MAgnetic Components,FP6,30 November 2008,30 August 2005,2269881.98 EMALI,Kaiserslautern University of Technology * Technische Universität Kaiserslautern,information and communications technology,"The proposed network will develop general theoretical and experimental techniques for engineering, manipulating andcharacterizing quantum states of matter and light. Realistic quantum technologies will require broad and robust mastery ofthese basic capabilities. The network will thus apply universally applicable principles of control theory and atomic and optical physics to a broad range of physical systems of varying complexity. It will move recent advances in pure science toward practical utility, by expanding and optimizing our control over quantum systems, to achieve desired results most efficiently and extract maximal information from measurements.The network will combine the experimental and theoretical expertise of leading groups working on quantum optics, single-atom cavity quantum electrodynamics, ion traps, Bose-Einstein condensates in optical lattices, optimal control theory, quantum dots, and interaction of light with atomic ensembles. Groups will employ overlapping methods, such as resonant and adiabatic techniques, optimal control procedures, and measurement-based feedback approaches. They will solve comparable problems in preparing specific non-trivial quantum states of matter and light, transferring quantum properties between matter and light, and demonstrating these achievements by characterizing quantum states tomographically.The network will train both early-stage and experienced researchers, who will visit multiple network sites, and benefit from the network’s broad international perspective in gaining scientific expertise as well as valuable complementary skills. They will organize and conduct a Young European Physicists meeting, and attend an open summer school, annual network meetings, plus three unique mini-schools. The mini-schools will combine tutorial courses in quantum engineering with practical problemsolving sessions for sharing experience gained in the network, and so foster transfer of knowledge among researchers at all levels.","Engineering, Manipulation and Characterization of Quantum States of Matter and Light",FP6,30 September 2010,01 October 2006,4394997.0 EMATTER,Sofia University * Sofiiski Universitet Sveti Kliment Ohridski,health,"The proposed research is in the field of nanofiber materials, focusing on the development of functional nanofibers for the complementary purposes of energy production and sustainable energy use. Significant opportunities exist in these areas, stemming from the development of several methods in the last decade for higher capacity nanofiber production, as well as the strategic need to find alternatives to current production of energy and its uses. Nanofibers are expected to bring revolutionary advances to these and many other fields of science and technology, including catalysis, filtration, protein separations, tissue engineering, and flexible electronics. We will work on creating such materials with potential applications in multi-exciton photovoltaics and catalysis for energy production. For sustainable energy use, we will develop bioinspired responsive materials and architectures, which would store energy, release it on demand, and act as life-like, efficient, and autonomous entities. Fundamental questions we will address in the research include: How do we tailor semiconductor band structures, as well as achieve nanoscale morphologies for efficient dissociation of photogenerated excitons? Can we develop general predictive rules for the conditions needed to fabricate nanofibers from any polymer solution by liquid shear processing? Can the molecular crystallinity and porosity be controlled in the fibers? What are the simplest life-like, autonomous devices that could be made with synthetic materials? This work will include extensive solution-based synthesis, processing, structural and chemical characterization (by optical and electron microscopy, small angle X-rays), physical property measurements (mechanical, optical, electronic), device fabrication and assembly, and computer simulations. Most of the facilities needed for the research are available in Cambridge, and some will be arranged for through external collaborations.",New materials for energy production and sustainable energy use,FP7,31 January 2017,01 February 2012,1963834.0 EMBEK1,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"90% of bacteria are found attached to solid surfaces forming structures (bio-films), that are inaccessible to drugs and antibiotics. These bio-films represent a major problem in European society in both industry and health care. Currently, however, we understand little about how these bio-films form and, more importantly, how they can be prevented. This lack of understanding means that patients often suffer 'unnecessary' and painful infections following the formation of such films on surgical implants and catheters. With the growing problem of MRSA and C. difficile in hospitals, and the cost of policing and hygiene measures, an understanding of how to prevent bacterial persistence in the hospital environment is critical to the sustainability of European healthcare. A multi-disciplinary group of European experts have the common aim to understand exactly how bacteria attach to, and persist on both biological and inert surfaces. We will use a range of biological and physio-chemical techniques to study several fundamental aspects of bacterial attachment. We will employ new molecular microbiology techniques to understand the genetic components governing the interaction of a bacterial biotic cell surface with the novel antimicrobial surfaces we create. Second, we will be using new nano-scale material science and physical chemistry techniques to create and understand these antimicrobial surfaces. This duel systems approach will allow us to theoretically model the processes of bacterial attachment and survival, which in turn will allow us to improve these surfaces in an iterative approach. We will generate intellectual property around the coatings and treatments used to derive the surfaces and develop these in collaboration with industry. The solutions will be designed specifically for the industrial partners participating in the project but can, with a minimum effort be adapted for applications in other areas through the iterative steps within the WPs.",Development and analysis of polymer based multi-functional bactericidal materials,FP7,31 July 2011,01 August 2008,2914466.0 EMC IN APT,London School of Economics and Political Science,energy,"The properties of interest of functional materials are strongly correlated to their intimate structure down to the nanometre scale. Designing novel, more efficient materials requires a control over their structure and chemistry at the very same scale. One of the challenges of the 21st century is to tailor energy conversion materials enabling a more efficient harvesting of the energy of the Sun. Thermoelectric power generation is a well-known effect through which thermal energy (heat) is directly converted into electricity without any intermediate working fluid or any moving parts. These materials are generally highly doped, nanostructured materials. Although very promising, the structure -activity relationship in this class of materials is still really unclear, due to a lack of nano-scale characterisation. I aim here to get trained on several analytical techniques, including dual beam Scanning Electron Microscope/Focused-Ion-Beam, Atom Probe Tomography (APT), and various declinations of Transmission Electron Microscopy. I will also acquire a better understanding on the functioning of the laser-assisted APT, which will enable me to start a collaborative work to correct the intrinsic aberrations of the technique. Drawing on the experience of the host group in conducting a complete materials science study, I will improve my skills in this field, and acquire methods, protocols and knowledge enabling me to solve materials science problems. This training will permit to perform at the same time an in-depth study of the multi-scale characterisation of the structure and chemistry of these materials, aiming to improve the design and efficiency of thermoelectric devices.",Towards the analysis of energy conversion materials at the atomic scale,FP7,31 August 2010,01 May 2009,184752.0 EMDPA,HORIBA Jobin Yvon SAS,manufacturing,"EMDPA will provide research laboratories and industry with a unique 'multi-dimensional' analysis tool of all types of layered materials, allowing direct, simultaneous elemental and molecular quantitative measurements with a sensitivity down to 100 ppb in the depth profiling mode for all elements of the Periodic Table, in observed zones of millimeter dimensions, through the development of a Micro Modulated or Pulsed Radio Frequency Glow Discharge Time of Flight Mass Spectrometer. Such instrument represents a major breakthrough as it will change the way surface and depth profiling analysis is regarded, being ultra fast, easy to use and low cost. The instrument is dedicated to the depth profiling of advanced materials made of conductive and/or non-conductive thin layers down to the nanometer scale. The development of such a radically new analytical instrument requires the understanding of key-phenomena: - Understanding/modelling of the sputtering mechanisms and ionization processes - Characterization of sputtered surfaces and understanding/modelling molecular chemistry in plasmas - Ion transport phenomena and detection methods - Assessment of performance properties The European critical mass proposed is a cross multidisciplinary consortium gathering 10 multi-disciplinary organisations coming from 5 different member states (France, Germany, Italy, UK, Spain), with 1 associated country (Switzerland) and 1 candidate country (Romania). The partnership embraces experts in plasma physics/chemistry and plasma-surface interactions (CPAT, NILPRP, UNICT), renowned groups in GD-MS design, chemometrics and data handling (ISAS, UNIOVI, EMPA), a recognised research centre with expertise in all aspects of material sciences (UoM), a provider of innovative TOF MS technologies (TW) and a large company manufacturing GD optical spectrometry instruments (HJY).",New Elemental and Molecular Depth Profiling Analysis of Advanced Materials by Modulated Radio Frequency Glow Discharge Time of Flight Mass Spectrometry,FP6,31 August 2009,01 September 2006,2098558.0 EMERGE,University of Strathclyde,manufacturing,"Functional nanomaterials are predicted to have an enormous impact on some of the most pressing issues of 21st century society, including next-generation health care and energy related technologies. Bottom-up approaches, using self-assembly principles, are increasingly considered to be the most appropriate routes for their synthesis. Indeed, Science magazine highlighted How far can we push chemical self-assembly? as one of the 25 biggest questions that face scientific inquiry over the next quarter century. Despite significant advances in recent years, it is still a major challenge to access precisely defined nano-structures in the laboratory, especially if these do not represent the global free energy minimum (i.e. are asymmetric, multifunctional, compartmentalized and/or dynamic). The biological world provides numerous outstanding examples of highly complex functional nano-scale architectures with attractive features such as defect repair, adaptability, molecular recognition and programmability. It is the objective of this ERC Starting Grant to develop and exploit the concept of (bio-)catalytic self-assembly, a bio-inspired approach for bottom-up synthesis of complex nanomaterials. We will explore three unique features of these systems (i) spatiotemporal control, (ii) catalytic amplification, either towards or away from equilibrium and the tempting vision of (iii) dynamic systems with emergent properties. In our approach we aim to encompass the entire spectrum from fundamental understanding to eventual societal benefit. Alongside the fundamental aims, we wish to put our methodologies to use, in collaboration with experts in these fields, to develop novel functional materials towards applications in next-generation biomaterials and gel-phase supramolecular (opto-) electronic materials.",Enzyme Driven Molecular Nanosystems,FP7,12 July 2017,01 January 2011,1500000.0 EMM3,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"Third generation solar cells represent alternatives to traditional bulk and thin film devices. They constitute a novel way to improve the ratio between photovoltaic efficiency and total cost, by including new physical principles and materials. This proposal combines two complementary aspects of third generation solar cells: new materials and new materials combinations and new physical mechanisms for photovoltaic conversion. The initial phase of the proposed research is mainly material characterization oriented: (i) Study of the combination of materials –such as InGaN, InN superlattices- which can lead to the formation of intermediate bands through the implementatuion of nanofrabrication technologies (ii) combination of optical spectroscopy and electronic transport techniques for the study of physical phenomena such as up/down conversion and intermediate band formation. In a second phase, the initial results and methodologies will be combined with the know-how within the host institutions through close collaborations, and the research will evolve towards the realization of photovoltaic devices based on nanostructured material.",Emerging Materials and Methods for 3rd generation solar cells,FP7,31 August 2013,01 September 2010,250392.0 EMMA,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"This project will investigate the feasibility of emerging new non-volatile memory concepts based on resistive-switching materials for enabling new mass-storage memory systems. These new memory concepts allow integration of the memory element in contact and interconnect structures resulting in very small memory cells and even offer the possibility of 3-D memory layer stacking. These new memory solutions are needed for the sub-32nm integration technology nodes where current memory concepts will no longer scale. The program will study high-density resistive switching non-volatile memories, including binary resistive switching oxides and Cu-TCNQ. Focus will be on concept scalability, based on gained understanding of the physical operation concepts. Investigation will further include cell integration aspects, reliability assessment, and memory architectures.",Emerging Materials for Mass-storage Architectures,FP6,30 November 2009,30 August 2006,2568783.3 EMOMFSSA,University of Cambridge,manufacturing,"This project aims to synthesise new metal-containing polymeric materials through self-assembly from simple building blocks. These self-assembled materials will be formed in water directly from diamine and dicarbonyl monomer units linked by imine bonds coordinated to copper(I) templates. The project is intrinsically multidisciplinary, building upon the techniques of organic synthesis and coordination chemistry to branch into applications in the fields of self-assembly and polymer chemistry. It spans the fields of organic and inorganic chemistry, bridging into materials science and nanotechnology. The project builds upon the experience of the applicant in metallo-supramolecular and materials chemistry to gain a deeper understanding of how subcomponent self-assembly may be used synthetically to generate complex and functional metal-organic materials. Then materials properties of the products including their electrical conductivity and light-harvesting properties will also be investigated. The materials produced will be dynamic-covalent polymers, capable of interchanging monomer units in solution. Despite their dynamic nature, the imine bonds between monomer units are not prone to rupture (C=N bond dissociation energy > 600 kJ mol-1), which could lead to strong polymer chains, and it has been demonstrated that coordination to copper(I) renders imines stable to hydrolysis even in aqueous solution. Although this project builds upon concepts developed in the fields of supramolecular and coordination polymers, the robust nature of the linkages between monomer units sets this project apart from these fields. The materials that will be prepared are predicted to be stiff and strong, and initial studies indicate that they could serve as electrically conductive “molecular wires†and lead to applications as sensors, conductors, magnetic materials or light harvesting devices.",Extended metal-organic materials formed via subcomponent self-assembly,FP7,04 May 2012,04 June 2010,174240.8 EMSWIM,Charles University * Univerzita Karlova v Praze,photonics,"The proposal is focused on the fundamental and applied research of electromagnetic and spin wave processes in laterally patterned periodic nanostructures and derived metamaterials and devices, with particular interest in magnetic materials. The research aims at the development and computer implementation of a theoretical approach capable of modeling the electromagnetic response of the nanostructures, their numerical and experimental investigation, proposing and designing novel applications, and studying related physical phenomena such as photon-spin wave interactions. Graphical, user-friendly software based on the numerical algorithm will be utilized for a commercial scatterometric system in the frame of international collaboration with Dainippon Screen Mfg. Co. Ltd., Japan. The project will use magneto-optical spectroscopy available at the host institution and other optical, magneto-optical, and complementary magnetism- and surface-science techniques provided by collaborating laboratories in the Czech Republic, Germany, and Japan. The results obtained on the nanostructures will be used to propose and design novel artificial metamaterials (such as magneto-photonic crystals) and devices (such as waveguides, microcavities, polarizing, space-modulating and other optical filters).",Electromagnetic and spin wave interactions in magnetic nanostructure-based metamaterials and devices,FP7,31 March 2012,01 April 2008,100000.0 EN-LUMINATE,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,health,"Being able to enhance and tune the interaction of a light wave with a molecule or nanoparticle on a fundamental level opens up an exciting range of applications such as more efficient solar cells, more sensitive photon detectors and brighter emitters for lighting applications. Nanoplasmonics promises to offer this level of control. Taking the current knowledge on nanoantennas a step further we will integrate them in organic and carbon-nanotube light-emitting devices to improve and tune their emission in unprecedented ways. As our testing platform we will use light-emitting field-effect transistors (LEFETs). Their planar structure, where the light emission zone can be positioned at any point allows for easy and controlled incorporation of plasmonic structures without interfering with charge transport. LEFETs can be made from a wide range of semiconducting materials. We will apply nanoantennas in LEFETs to 1) Enhance electroluminescence of high mobility organic semiconductors 2) Tune excitation decay and transition selection rules in organic semiconductors and 3) Enhance photo- and electroluminescence of single-walled carbon nanotubes. All of these materials offer high carrier mobilities and therefore high currents but have very low fluorescence efficiencies that can be improved substantially by nanoantennas. We will study the influence of nanoantennas on the fundamental emission properties of these different types of emitters. At the same time we will improve their efficiency in light-emitting devices and thus enable new and innovative applications.",Enhancing and Tuning Electroluminescence with Nanoantennas,FP7,30 November 2017,01 December 2012,1496684.0 ENCASIT,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"The aim of this project is to gather and disseminate information related to Systems Integration and System in a Package for various types of technologies including Semiconductor, MEMs, Nano- Bio- etc. in a variety of mass-market applications of importance to European industry. The project also plans to assess how technologies are developing to address High Temperature and Harsh Environments as seen in Auto, Aero and other applications. The project office will be run by IMEC who will also maintain the Network membership, web site and publish newsletters twice a year. A Conference will be organised once during the two year project and specialist workshops will be held in various European locations. The project also intends to be actively involved in standards drafting, especially for IEC standards, through IEC/PT62258 and other standards committees as appropriate. The project will maintain links with other organisations worldwide, to both promote the Network and to gather information from other orgainsations, and will promote the services offered by SMEs to this industry through a User Club.",European Network for Coordination of Advanced System Integration Technologies,FP6,29 February 2008,29 December 2005,493000.0 END,STMicroelectronics Srl,information and communications technology,"Energy efficiency is one of the most critical aspects of today’s information society. Reducing the energy consumption of electronic devices, circuits and systems as well as improving energy generation, conversion, storage and management capabilities are the main challenges that engineers and scientists have to face in the next decade. The ENIAC JU project END targets the development of innovative energy-aware design solutions and electronic design automation technologies for the next generation of nanoelectronics circuits and systems, and related energy generation, conversion and management systems.","Models, Solutions, Methods and Tools for Energy Aware Design",FP7,03 January 2013,04 January 2010,2192631.0 ENE-HVAC,Danish Technological Institute * Teknologisk Institut,energy,"In residential and commercial buildings, Heating, Ventilation, and Air Conditioning (HVAC) systems constitute about 35% of the total energy consumption. Although today, heating is the most energy demanding need, there is an increasing demand for cooling which is expected to increase even further in the years to come due to climate changes. To decrease the overall energy demand, it is vital to look for new and innovative technologies for increasing the efficiency of currently applied state-of-the-art HVAC systems. To efficiently tackle the need for less energy demanding HVAC systems for both residential buildings and commercial facilities, the overall focus of EnE-HVAC focus will be on the energy efficiencies heat transfer addressing on both the air side- and the refrigerant side of the systems. It will also, importantly, tackle the energy transportation within the system to ensure maximum efficiency. This will require very high performance characteristics of the refrigeration agents in use. To ensure a significant impact on global warming, there will be a focus on developing the use of coolants with no HFC and CFC content. The specific aim of EnE-HVAC is to facilitate a significant reduction of the total energy consumption in modern HVAC systems by combining a range of new nanotechnological solutions. There will be a clear focus on the optimization of the heat transfer of heat exchangers used in HVAC systems such as condensers and evaporators in HVAC systems, along with the design of systems and the development of new nanomaterial enhanced HFC and CFC free refrigerants. The culmination of the present project will be the demonstration of energy savings of up to 50% on the total energy consumed in the developed HVAC systems compared current to state-of-the-art commercial systems. The EnE-HVAC consortium comprises industry market leaders representing the value chain and leading research institute in surface technology and heating/cooling.",Energy efficient heat exchangers for HVAC applications,FP7,30 September 2015,01 October 2012,2904904.0 ENERGOSIL,University of Cambridge,energy,"The main objective of this project is creation of porous silicon films with effective light absorbance on technically important metallic substrates such as steels, aluminium alloys and copper as well as metal-coated glass. This will give the possibility of combining structural materials with silicon for facing panels for buildings, which could be used to harness solar energy. The project aims to create highly efficient silicon films with nano-micro porous architectures, which will improve the efficiency of solar energy harvesting due to light trapping by internal reflection. The proposed concepts and methods are relevant to a wide range of applications where specifically high silicon surface to volume rates are of importance: solar cells, solar-driven generation of hydrogen, electrodes for lithium-ion batteries, precursors for production of silicon nano-particles and platforms for chemical and biological sensors.",Silicon Films on Metals for Energy Applications,FP7,06 January 2015,07 January 2013,258306.0 ENF 2009,AVCR - Technology centre * Technologické centrum,environment,"The conference EuroNanoForum 2009 will be established as a foremost European congress in Nanotechnology within the framework of the Czech presidency. The conference will address the impact of nanotechnologies on sustainable economy focusing on their applications in resource- and eco-efficient industrial production, environmental protection and remediation, and energy production and conservation in the coming years. It aims to: (i) present the nanotechnology state of the art in the realm of sustainable economy;(ii) facilitate intensive exchange of views, information and experience between researches and representatives of industry, investors as well as policy makers and representatives of civil society; (iii) foster networking and knowledge transfer between different national and European stakeholders; and (iv) promote responsible governance in nanotechnology.","Organization of the Conference EURONANOFORUM 2009 \"Nanotechnology for Sustainable Economy\"",FP7,10 July 2011,11 January 2008,394300.0 ENF2005,Institute of Nanotechnology,health,"This SSA is for support for a 5-day conference on the theme 'Nanotechnology and the Health of the EU Citizen in 2020' from 5-9 September 2005 in Edinburgh. It is being organized by The Institute of Nanotechnology. It will build on the success of EuroNanoForum2003, and promote developments in nanotechnology that are leading to innovative solutions for health and healthcare in Europe as part of an integrated and responsible approach. The format will be a combination of thematic workshops, public debate, forums, and conference showing the state-of-the-art. EuroNanoForum2005 is forming a prestigious element of the UK's 6th Presidency of the EU, which runs from June to December 2005. It will also be timely in terms of reinforcing the EU policy for research funding for nanotechnology and converging technologies in the Seventh Framework Programme. EuroNanoForum2005 will explore several critical issues, such as the ongoing competitiveness of the European healthcare industries; meeting the demands of an ageing population, the early diagnosis and potential cures, for example, of cancer, cardiovascular disease and inflammatory diseases. It aims to demonstrate the potential of nanotechnologies to address these issues, support the creation of high quality jobs, and underpin important EU objectives such as the Lisbon Agenda. To achieve its aim, EuroNanoForum2005 will promote exchanges on groundbreaking European research in nanotechnologies as applied to healthcare, bringing together key industrial players, academia, and policy makers, in an international context. Key themes include: - A review of EU research progress since 2003 - A look to FP7, and the role of convergent technologies in the EU strategy for healthcare - New developments in tissue engineering; targeted drug delivery; biomaterials; analytical, imaging and sensing techniques - How ethical, environmental, social, safety & risk concerns are being addressed - Nanomedicine for the developing countries",EuroNanoForum2005 - 'Nanotechnology and the Health of the EU Citizen in 2020',FP6,14 March 2006,15 December 2004,300000.0 ENFIRO,Stichting VU-VUmc * Foundation VU - VUmc,environment,"Brominated flame retardants (BFRs) will be phased out because of their environmental hazards. Less toxic alternatives appear to be available already but comprehensive information on their possible toxicological effects are lacking. ENFIRO offers a prototypical case study on substitution options for BFRs resulting in a comprehensive dataset on viability of production and application, environmental safety, and a complete life cycle assessment. Dissemination will ensure the project results to arrive at policymakers' desks. The ENFIRO consortium is a unique collaboration between industries, SME's and universities with a wide variety of scientific disciplines. ENFIRO will contribute to the phasing out of BFRs as proposed in the European Water Framework Directive. The approach and the results of ENFIRO will be useful for similar substitution studies, e.g. in REACH. Following a study on literature and industrial information, and prioritizing , three flame retardant (FR)/product combinations will be selected (e.g. metal-based FRs, phosphorous-based and nanoclay-based FRs in printed circuit boards, paints and foam). These will be studied for environmental and toxicological risks, and for viability of industrial implementation, i.e. production of the FR, fire safety and application of the FR into products (electronics, furniture, paints, foams, etc.). All information from these tests will be used for a risk assessment. The outcome of that assessment will, together with socio-economic information be used in a complete life cycle assessment. The project will follow a pragmatic approach, avoiding final recommendations on environment-compatible substitution options that would not be viable for implementation by industry. A Substitution Information Exchange Forum with members representing FR users (large industries) has been invited to guide this project.",Life Cycle Assessment of Environment-Compatible Flame Retardants ( Prototypical case study),FP7,11 June 2014,09 January 2009,3157554.04 ENGINEERED OXIDES,Imperial College London,energy,"Development of new energy conversion technologies are a prime concern for the EU. To achieve low emissions and high efficiencies new materials advances are required. Research on new oxide materials with both high ionic and electronic conductivity (MIEC: mixed ionic and electronic conductors) is of key importance in order to achieve optimum performance in electrochemical energy conversion devices such as solid oxide fuel cells, gas sensors, oxygen membrane generators and catalytic oxidation systems. Particularly, in these applications there is a major interest in reducing the working temperatures to about 600 °C. Control over the electronic and ionic conductivity of the MIEC material, as well as the oxygen surface exchange kinetics is therefore a crucial issue. We propose to study several very promising MIEC ceramic materials, from both the Ruddlesden-Popper Ln2NiO4+x (Ln = Nd, Sm, Pr) family and the layered cobaltite (GdBaCo2O5+x) family. Both families of compounds have anisotropic ionic and electronic transport properties, and therefore in order to extract information about their intrinsic anisotropic properties, single crystals and epitaxial thin films will be measured. In addition we will study new engineered layered oxide thin films materials with different heterointerfaces, which very recently have attracted increasing interest due to some outstanding results which include high ionic conductivity and oxygen exchange enhancement. Once these studies have been performed we will try to design new engineered thin films by using perovskite layers and rock-salt type layers as building blocks to control nanostructures with optimized tailored properties. In addition, the study of the variation of these properties for films submitted to different stress will enable innovation that will be of interest in designing new MIEC materials with enhanced performance for different types of advanced electrochemical devices, of great importance in the changing energy economy.",Design of New Engineered Oxide Thin Films with Tailored Properties,FP7,02 August 2013,01 February 2011,172740.0 ENHANCE,Ruhr University Bochum * Ruhr-Universität Bochum,energy,"The multi-site European initial training network -'ENHANCE' -'New Materials: Innovative Concepts for their Fabrication, Integration and Characterization' will be established to deal with the mid and long term issues of concern to the European industry encompassing the whole spectrum of functional materials for microelectronics, nano-electronics, data storage, photovoltaic, with emphasis on emerging nano-technologies. This network consisting of 3 academic groups from chemistry 1 from physics, 3 from Material Science and Engineering and 1 industrial partners from 6 different countries of Germany, Finland, Netherlands, Italy, Denmark and Austria. Despite the exceptional importance of thin film processing of many new materials and their integration in emerging nanotechnologies, there is no systematic interdisciplinary training of students in the traditional courses of chemistry, materials science and engineering. ENHANCE aims to close this gap by combining the classical knowledge of chemistry, materials science, physics and engineering i.e. the knowledge of precursor molecules, materials properties, study of physical phenomena, to electronic devices and circuit integration. The training of ENHANCE fellows will be based on a structured 3 year academic curriculum, including, generic skills workshops and on-site research training at the state of the art laboratories, facilities under clean room conditions and a training at the industrial laboratories. This will provide the young scientists with necessary in-depth knowledge in materials synthesis and thin film processing as well as experimental skills in operating the instruments and analytical skills in different materials characterization techniques. The training concludes with European doctoral examination and will be reviewed by external experts in the field and their remarks will be addressed during the final disputation.","European Research Training Network of 'New Materials: Innovative Concepts for their Fabrication, Integration and Characterization'",FP7,30 September 2013,01 October 2009,3697708.0 ENHANCED EUROTALENTS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),photonics,"CEA is convinced that the research institute ability to offer attractive working conditions and career opportunities to researchers is a key factor in maintaining and boosting Europe's scientific and economic competitiveness. Thanks to the EU cofunding, CEA would like to enhance its centralised programme called Eurotalents, dedicated to researchers' transnational mobility and based on open merit competition and international peer review. Eurotalents already cofunded by the Commission was a great success. With Enhanced Eurotalents (E2), CEA wants to foster its programme aiming at increasing the mobility of scientists and at offering a boost in their career thanks to the access to new research capacities. E2 opens world class laboratories within CEA and abroad to researchers having an excellent scientific experience and willing to broaden their career via a research project in the scientific topic they can select within CEA well-known domains of expertise: i)Energy, environment and climate change, ii)Life sciences and biotechnology, iii)Key Enabling Technologies: Microelectronics, nanosciences and nanotechnologies, photonic, advanced material and manufacturing, iv)High energy physics, high energy density physics and astrophysics. E2 offers thus 2 different fellowship schemes: Incoming Fellowships and Outgoing Fellowships. Awarded researchers will have a better salary because of the mobility allowance allowed by the EU funds, and have access to training courses in scientific and non scientific subjects. E2 is directly operated by CEA which has proved its capacity to efficiently manage European projects and national programmes according to strict rules. E2 exploits synergies between EU actions, CEA quality of work, research facilities and scientific environment. E2 contributes to the success of the ERA by promoting EU mobility and attracting third country researchers. A major added value of E2 is to make EU an attractive location to develop their talents.",Enhanced Eurotalents: a European programme for transnational mobility of experimented researchers managed by CEA,FP7,31 December 2018,01 January 2014,9994696.0 ENHANCEMENT ETHICS,London School of Economics and Political Science,health,"The main objectives of this project are (i) to address relevant ethical aspects of human enhancement from a virtue ethics perspective and (ii) to identify and explore the philosophical dimensions of ownership of biological material which are related to human enhancement. My host and supervisor will be Professor Julian Savulescu who is the director of 'The Oxford Uehiro Centre of Practical Ethics' and the director of 'The Program of Ethics and the New Biosciences in the 21st Century School' at University of Oxford. The project has strong interdisciplinary features and will involve: moral philosophy, ethics of technology, medical ethics, neuroethics, enhancement technology and jurisprudence. This broad approach is reflected in the choice of supervisor; Professor Julian Savulescu is qualified in medicine, bioethics and analytic philosophy, as well as host organisation; The Uehiro Centre for Practical Ethics at Oxford University. In addition I will have the support of Dr. Roger Crisp, a specialist in ancient philosophy at St. Anne's College in Oxford and Professor Francois Berger, leader of the research group 'Brain nanomedicine group' at INSERM U836 at University of Grenoble in France. The research will result in a series of four (4) articles, intended for publication in peer-reviewed journals.",Ethical aspects of human enhancement and the ownership of biological material,FP7,31 August 2010,01 September 2008,161225.0 ENLIGHTENED,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"« Mass Spectrometry has become a routine analytical tool in modern biological research, and has gained in recent years a foothold in the realm of clinical diagnostic and screening. However, it is still costly, complex and because its principle relies on ionization, it is incapable of analyzing biomolecules with masses greater than a few MDa. Averaging more than 100 million particles per measurement, it is also incapable of characterizing the diversity of such heavy entities. ENLIGHTENED aims at demonstrating a breakthrough concept based on Photonic Nano-Mechanical Mass Spectrometry, able to perform analysis of bioparticles of high biomedical significance, of ultra-high mass, never so far characterized, with single-molecule sensitivity and unprecedented resolution. The long-term vision beyond the current proposal is to provide the biologists with a tool which will be transformative for fundamental knowledge, and to make possible cheap, handheld devices for personalized medicine. ENLIGHTENED proposes to use photons to shed light on unexplored species at the individual level, which is of high biomedical significance and will expand our understanding of simple life forms.'",Nanophotonic Nanomechanical Mass Spectrometry for Biology and Health,FP7,31 May 2019,01 June 2014,1999090.0 ENNSATOX,University of Leeds,health,"The use of engineered nanoparticles in cosmetics, pharmaceuticals, sensors and many other commercial applications has been growing exponentially over the past decade. EU and Member State's research into the environmental impact of these materials, particularly in aquatic systems, is at an early stage. ENNSATOX addresses this deficit through a, comprehensive investigation relating the structure and functionality of well characterised engineered nanoparticles to their biological activity in environmental aquatic systems. An integrated approach will assess the activity of the particles in a series of biological models of increasing complexity. Parallel environmental studies will take place on the behaviour of the nanoparticles in natural waters and how they modify the particles' chemical reactivity, physical form and biological activity. An integrated theoretical model will be developed describing the environmental system as a series of biological compartments where particles transport between a) compartments by advection-diffusion and b) between phases by a transfer function. Following optimisation of the transfer functions a generic predictive model will be derived for the environmental impact of each class of nanoparticle in aqueous systems. A generalised understanding of the dependence of the nanoparticle biological activity on its structure and functionality will be obtained including the role and interaction of the biological membranes within organisms. ENNSATOX will generate: 1) exploitable IP (devices and ecotoxicology predictive software package); 2) set of standard protocols for assay of nanoparticle biological activity which can be later accredited; 3) global dissemination of results; 4) creation of an EU laboratory service; 5) tools and data to inform EU Regulation and the EC's code of conduct for responsible nanosciences and nanotechnologies research, ftp://ftp.cordis.europa.eu/pub/nanotechnology/docs/nanocode-recommendation-pe0894c08424_en.pdf.","Engineered Nanoparticle Impact on Aquatic Environments: Structure, Activity and Toxicology",FP7,30 June 2012,01 July 2009,2816500.0 ENOC,University of Barcelona * Universitat de Barcelona,photonics,"In Europe, several clusters in optics and photonics exist; Each one trying independently to promote and develop activities in optics and photonics in its home country but without links to other European clusters. With this project, we propose to create a pan-European network to link the various optical clusters across Europe in order to develop relationships and establish best practise in knowledge transfer. This project aims to coordinate the various optics networks. It is articulated around three main ideas : 1. Utilising existing national clusters with close links to universities and industry in the home countries. 2. The development of partnerships and improved relationships between clusters from different countries, thereby helping academics and industrials across Europe achieve better coordination to the benefit of the European economy. 3. The analysis of a common methodology and formation of a best practise to improve the networking between these clusters and as a baseline for the development of this network and other clusters in the same field. There is a hope that this best practise could be exported to other technology fields such as biotechnology, nanotechnology. This project will involve several European partners including Greece, Italy, Spain and the United Kingdom in the proposed European Network of Optical Clusters (ENOC).",European Network of Optical Clusters,FP6,14 June 2008,15 December 2005,873802.0 ENPRA,Institute of Occupational Medicine,health,"Engineered Nanoparticles (ENP) are increasingly produced for use in a wide range of industrial and consumer products. Yet it is known that exposure to some types of particles can cause severe health effects. Therefore it is essential to ascertain whether exposure to ENP can lead to possible health risks for workers and consumers. We have formed a consortium of well-known scientists from European Universities and Research Institutes, with over 100 publications in the field of Nanotoxicology. Our aim is to develop an approach for the Risk Assessment of ENP (ENPRA). Our objectives are: (i) to obtain a bank of commercial ENP with contrasting physico-chemical characteristics and measure them; (ii) to investigate the toxic effects of ENP on 5 (pulmonary, hepatic, renal, cardiovascular and developmental) target systems and 5 endpoints (oxidative stress, inflammation; immuno-toxicity; fibrogenecity; genotoxicity) using in vitro animal/human models; (iii) to validate the in vitro findings with a small set of carefully chosen in vivo animal experiments; (iv) to construct mathematical models to extrapolate the exposure-dose-response relationship from in vitro to in vivo and to humans; (v) to use QSAR like models to identify the key ENP characteristics driving the adverse effects; (vi) to implement a risk assessment of ENP using the Weight-of-Evidence approach; (vii) to disseminate our findings to potential stakeholders. To harmonise the research activities between our EU group and the US, we have established links with scientists from US Universities (Duke, Rochester) and Government Agencies (NIH/NIEHS, NIOSH and EPA) with on-going research in Nanotoxicology. Our objectives here are (vii) to share information and agree on experimental protocols; (viii) to avoid duplication of work; (ix) to further validate the findings of this proposed study.",RISK ASSESSMENT OF ENGINEERED NANOPARTICLES,FP7,31 October 2012,01 May 2009,3700000.0 ENREMOS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Imparting chirality to non-chiral metal surfaces by adsorption of chiral modifiers is a highly promising route to create effective heterogeneously catalyzed processes for production of enantiopure pharmaceuticals. A molecular-level understanding of enantioselective processes on chiral surfaces is an importance prerequisite for the rational design of new enantiospecific catalysts. With the research outlined in this proposal we are aiming at a fundamental level understanding of the structure of chirally modified surfaces, the bonding of the prochiral substrate on the chiral media and the details of the kinetics and dynamics of enantioselective surface reactions. A full mechanistic picture can be obtained if these aspects will be understood both on the extended single crystal surfaces, mimicking a local interaction of the modifier-substrate complexes with a metal, as well as on the small chirally modified nanoparticles that more accurately resemble the structural properties and high catalytic activity of practically relevant powdered supported catalyst. To achieve these atomistic insights, we propose to apply a combination of ultrahigh vacuum (UHV) based methods for studying reaction kinetics and dynamics (multi-molecular beam techniques) and in-situ surface spectroscopic and microscopic tools on well-defined model surfaces consisting of metal nanoparticles supported on thin single crystalline oxide films. Complementary, the catalytic behaviour of these chirally modified model surfaces will be investigated under ambient pressure conditions with enantiospecific detection of the reaction products that will enable detailed atomistic insights into structure-reactivity relationships.",Enantioselective Reactions on Model Chirally Modified Surfaces,FP7,31 December 2018,01 January 2014,1589736.0 ENRHES,Edinburgh Napier University,environment,"The overall aim of the ENRHES project is to perform a comprehensive scientific review of the health and environmental safety of fullerenes, CNTs, metal and metal oxide nanomaterials. The review will consider sources, pathways of exposure, the health and environmental outcomes of concern, in the context informing the regulation of the potential risks of engineered nanoparticles. We will employ a standardised information management strategy and a matrix approach to maximise the gain to partners and beneficiaries involved with the review. The specific objectives will be to review information on: production, use and exposure to the target engineered nanomaterials; persistence, bioaccumulation and interactions of the engineered nanoparticles in living & environmental systems; differences in toxicity posed by variations in size, type and chemical composition. On the basis of the review, prioritised recommendations on each of the above points will be developed and set in the context of informing policy makers in the development of methods to address exposure as it relates to the potential hazards posed by engineered nanoparticles, and in the development of appropriate regulation.",Engineered Nanoparticles: Review of Health and Environmental Safety,FP7,08 July 2011,09 January 2008,7.0 ENSEMBLE,Institute of Electronic Materials Technology * Instytut Technologii Materiałów Elektronicznych,photonics,"Growth of eutectics is recognized as a paradigm for pattern-forming. Self-organised structures of size scales reaching down to submicron and nano scale regime emerge due to the interplay of chemical diffusion and capillarity. The fundamentally novel CONCEPT of the present proposal is to utilize - for the first time - the eutectic self-organisation mechanism for preparation of multi-component and multi-scale structures with controlled physicochemical and structural properties, with geometrical motifs capable of generating novel, predictable and controllable electromagnetic functionalities. This requires a deeper understanding of factors influencing eutectic self-organisation mechanism on a submicron/nanoscale. Accordingly, the main topic and activity of the present proposal is to generate new knowledge of the mechanism of eutectic self-organisation on this scale, by combining state-of-the-art experimental and modelling techniques. This new understanding of the underlying processes of eutectic self-organisation will then be used for the prediction and design of self-organised multi-component and multi-scale structures with controlled physicochemical and structural properties. This will be combined with the electromagnetic design of complex structures which can generate revolutionary electromagnetic functionalities. This will result in: a) the ability to predict the occurrence of patterns in eutectic systems, b) knowledge on how to design nanopatterned materials with controlled physicochemical and structural properties, c) methodologies to design and to fabricate self-organised multi-component and multi-scale structures with revolutionary electromagnetic functionalities, and d) the experimental realisation of these self-organised systems. The planned research is expected to open new horizons for utilizing self-organised structures in the development of the next generation of materials for photonic application that will exhibit revolutionary properties.",ENgineered SElf-organized Multi-component structures with novel controllaBLe Electromagnetic functionalities,FP7,30 April 2012,01 May 2008,3899550.0 ENSENA,University of Innsbruck * Universität Innsbruck,photonics,"At the interface between quantum optics and semiconductors we find a rich field of investigation with huge potential for quantum information processing communication technologies. Entanglement is one of the most fascinating concepts in quantum physics research as well as an important resource for quantum information processing. This project will develop novel sources of entangled photon pairs with semiconductor nanostructures. In particular, we will use the scattering of microcavity exciton-polaritons as an extremely strong optical nonlinearity for the generation of entanglement with properties that are difficult to achieve with the traditional methods. Further we will work with individual semiconductor quantum dots to create controlled single entangled pairs and explore the interfacing of quantum dots to flying qubits. The long term vision of this research is to create integrated sources of entanglement that can be combined with laser sources, passive optical elements, and even detectors in order to realize the quantum optics lab on a chip.",Entanglement from Semiconductor Nanostructures,FP7,31 December 2015,01 January 2011,1259725.0 ENSOM,IMEP-LAHC Laboratory,energy,"The proposed project aims at developing and delivering a cutting edge analytical tool to provide unprecedented diagnostic capabilities for the characterization of nano/micromaterials of interest for energy conversion and storage, for nanoelectronic and catalysis, among others. To indeed optimize the design of new or existing nano/micromaterials, the fundamental reaction mechanism or properties of the active components have to be evaluated at the particle size level and therefore necessitate the development of a new generation of instrument that can combine physical observation, property characterization and local modification. The instrument we propose to develop, an electrochemical near-field Raman spectroscope (e-NSOM) will be used as a 'Nano/Microlab station' that will enable on site modification, nanospectroscopy, compositional mapping and conductivity properties evaluation. Equipped with unique hybrid probes used as ultramicroelectrodes and nano-optical antennas e-NSOM will extract the electrochemical and optical properties of the sample under scrutiny, at the nanoscale and from a single measurement implemented in situ. This combination of several individual functions in a single unit will not only bring new insights in the fundamental understanding of micro and nanomaterials but also open new routes to the functionalization or modification of material at the nanoscale. Initiation and evaluation of the charge propagation within conductive polymers at different time / length scale, control of the delithiation rate (charge depth) of single particle for energy storage and subsequent analysis of the phase propagation, fine tuning of the electron conduction properties of graphene by local grafting of molecules are some of the new routes we intend to explore. By developing and applying e-NSOM, we anticipate major breakthrough in the development of these materials with strong potential for industrial applications.",Electrochemical Near-fied Scanning Optical Microscopy / Manipulation and characterization at the nanoScale,FP7,30 September 2017,01 October 2013,100000.0 ENSOR,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,health,"The ENSOR project involves the exchange of key staff between the EU (United Kingdom and Hungary), Russia and Japan with a principal aim to focus on the controlled production and chemical modification of a variety of novel nanocarbons for specific end applications reaching into the bio-organic field. Specifically, we will tailor the geometry and physicochemical properties of nanocarbons for the development of biosenors, rapid bacteria screening in liquid media, DNA therapeutics, regeneration of damaged cells (peripheral nerve cells) and hemoperfusion adsorption. It is also recognised that the development of novel nanocarbons will have unique properties that will be beneficial in other research and development fields, e.g. next generation of ultracapacitors, advanced organic decomposition catalysts, superior mechanical reinforcement additives. Furthermore, the project provides training and education through collating the best techniques available within each country to provide international excellence, facilitating transfer of knowledge and know how between the participating parties, being of mutual interest, fostering long term collaborative format well beyond the scope of the project. To ensure success of the project, it is necessary to organize joint investigations of four teams from the University of Brighton (UoB, UK), Budapest University of Technology and Economics (BME, Hungary), Omsk University (Omsk, Russia), Kazan State University (KSU, Russia) and Toyo University (Toyo, Japan). The complementarily aspects existing between EU partners and those from Russia and Japan, as well as the multidisciplinary character of proposed research will create sufficient synergy to succeed the targeted goals and will result cross-fertilization of the consortium as a whole.",Evolving Nanocarbon Strategies in (bio-) Organic Remits,FP7,28 March 2015,29 March 2011,264900.0 ENTANGLED QUBITS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"The Marie Curie Intra-European Fellowship makes possible a one year visit by Dr Philip Meeson (University of Bristol, U.K.) to the Quantronics Group of Dr Daniel Esteve (CEA-Saclay, France). Dr Meeson is an experienced researcher in the field of fundamental physics of superconductivity and most aspects of ultra low temperature technology. He also has some research experience in mesoscopic devices. Recent research has focussed on the topic of quantum oscillations (the de Haas-van Alphen effect) in superconductors. He is a co-author of a recent graduate level textbook on low temperature techniques and a permanent member of staff in Bristol. Dr Esteve is the head of the Quantronics research group of the CEA-Saclay. The group is a world leader in nanofabrication and experimental aspects of the fundamental properties of nanoscale metals and superconductors. Most recently he has been responsible for the landmark development of the 'Quantronium', a superconducting nanoelectronic device which has greatly furthered knowledge of macroscopic quantum mechanics and which may form the basis of a future quantum computing technology. The purpose of the visit is to exchange knowledge and promote scientific excellence in the areas of superconducting nanotechnology and quantum qubits. One outcome of the research in Saclay will be to engineer the worlds first entangled multiple solid state qubit operating with single shot readout. Such an accomplishment is an obvious next step in the development of solid state quantum computing but the proposal is highly ambitious and requires the implementation of a number of difficult experimental conditions. A principal aim of this work is the transfer of knowledge of nanofabrication techniques from Saclay to a new research effort in Bristol to explore fundamental quantum behaviour in superconducting devices in Bristol. Future collaborations are also envisaged.",Quantum Entanglement in a Multiple Quantum Bit Solid State Circuit,FP6,02 February 2005,03 February 2004,103588.0 ENTANGLEMENT AND COM,"Imperial College of Science, Technology and Medicine",information and communications technology,"Entangled quantum systems behave in ways impossible in any classical world. Even as entanglement of simple composite systems is reasonably well understood, the nature of complex entangled systems is largely unexplored. We will investigate entanglement of increasing complexity, either by entangling more and more systems with each other, or by entangling systems with a larger number of degrees of freedom. Firstly, we plan to derive new Bell's inequalities (tests of quantum non-locality) for higher-dimensional entangled systems and a larger number of choices for measurement settings for each system. The contradiction of quantum mechanical predictions with local realism is expected to be even stronger than currently known. Secondly, the entanglement that naturally exists between constituents of various complex physical systems such as chains of interacting spins will be studied. We will investigate how the amount of entanglement between several spins varies with the change of the number of spins, the strength of the coupling between them, temperature, the strength of the external field etc. The second part of the project investigates whether and how much entanglement is needed for quantum communication and quantum computation to outperform those which are based on the laws of classical physics. Firstly, we intend to develop new quantum communication complexity protocols exploiting higher-dimensional entanglement and to derive their complexity as a function of the amount of entanglement used. We expect to observe an increase of the separation between the complexity of the quantum solution and the best classical strategy as the dimensionality of the entangled systems grows. Secondly, by considering quantum computation as a communication process we plan to derive the complexity of certain quantum algorithms as a function of the amount of entanglement consumed.","Quantum Entanglement, Complexity, Quantum Computation",FP6,31 December 2004,01 January 2004,82131.0 ENTAS,Northumbria University,energy,"Energy Storage Technologies have long been a subject of great interest from both academia and industry and are crucial for achieving the European climate energy objectives as defined in the European Union's (EU) '20-20-20' targets and in the European Commission's Energy Roadmap 2050. The focus of this proposal is on Latent Heat Storage which is currently a key international priority and is based on the use of Phase Change Materials (PCMs). One of the major challenges in the development of compact high performance Latent Heat Storage systems is the low heat conductivity of such PCMs. The main objective of this project is to perform systematic rheological, micro-structural and morphological analysis of the PCM composites with a combination of various nano-carbon additives with up to 5 wt%. Such parameters as the geometrical shape, orientation, alignment, cohesion, dispersion, distribution and interaction (contact) of nano-carbon particles with each other and PCM matrix will have a most significant influence and define the thermo-physical properties of PCM composites. Two types of PCMs will be investigated which includes organic (paraffin) and inorganic (crystallohydrate) materials with operating temperatures in the range between 60 and 100 deg.C. A correlation will be established between the rheology, micro-structure and morphology parameters and thermo-physical properties of the PCM composites. Such correlation will be used in manufacturing advanced cost effective PCM composites with optimised rheology, morphology and microstructure parameters and thermo-physical properties. Additionally thermal cycling tests of the selected new PCM composites will be performed to determine deterioration of thermal properties in time. Outcomes of the project will be used by a number of industrial companies across EU engaged in production of PCMs and Latent Heat Storage systems for various industrial and domestic applications.",Enhancing Thermal Properties of PCM Using Nano Materials,FP7,18 May 2016,19 May 2014,309235.0 ENVIGUARD,ttz Bremerhaven,health,"The objective of the EnviGuard project is to develop a highly specific and precise (i.e. quantitative and qualitative) in situ measurement device for currently hard to measure man-made chemical contaminants and biohazards (toxic microalgae, viruses & bacteria, biotoxins & PCBs) that can be used as an early warning system in aquaculture and as an environmental monitor to assess the good environmental status of the sea in compliance with the MSFD. It will be more cost-efficient than current monitoring devices leading to a clear marketing advantage for the European analytical and research equipment industry. The modular system will consist of three different sensor modules (microalgae/pathogens/ toxins & chemicals) integrated into a single, portable device, which saves, displays and sends the collected data real time to a server by means of mobile data transmission and the internet. EnviGuard will be able to accomplish this also in real-time for a period of at least one week without maintenance in an offshore, marine surrounding. User of EnviGuard can access their data online any time they need to. Potential fields of use are marine environment pollution monitoring, marine research and quality control in seawater aquaculture, a sector in Europe highly occupied by SMEs. The biosensors developed in the project go far beyond the current state-of-the art in terms of accuracy, reliability and simplicity in operation by combining innovations in nanotechnology and molecular science leading to the development cutting edge sensor technology putting European research and highly innovative SMEs in the forefront of quickly developing markets.",EnviGuard -Development of a biosensor technology for environmental monitoring and disease prevention in aquaculture ensuring food safety,FP7,30 November 2018,01 December 2013,5523461.0 ENVIRO,University of Southampton,health,"The scientific aim of enVIRO is to develop novel low-cost paper-based microfluidic systems for the detection of waterborne pathogens. Norovirus and E. coli will be the exemplar targets as they are the primary agents of global gastrointestinal infections caused by contaminated drinking and bathing water. Three-dimensional microfluidic paper analytical devices (µPADs) will be implemented with isothermal nucleic acid amplification technology (INAAT) for sensitive quantitation of pathogens in environmental samples. This will only be possible by joining the expertise in molecular biology and nanotechnology at the University of Southampton (UoS) with the pioneering excellence in paper-based microfluidics at the group of the inventor of the field, George Whitesides, at Harvard University (HU). The enVIRO project will be primarily a research-driven training programme with a 24-month outgoing period spent at HU, for development of novel prototype 3D INAAT µPADs for environmental samples, and a 12-month re-integration phase at UoS in ERA, for knowledge dissemination and prototype implementation that addresses increasing global and European needs in tackling water contamination and infection issues.",Low-cost paper-based microfluidic devices for the detection of waterborne pathogens,FP7,31 May 2017,01 June 2014,282109.0 ENVIROMIS-SSA,Siberian Center for Environment Research and Training (SCERT),information and communications technology,"ENVIROMIS-SSA forms coherent set of coordination, dissemination and education actions directly aimed at environment and health protection and related safety aspects, stabilisation of research and development potential in Russia and other NIS countries. Being based on modern monitoring, information and computational technologies it might indirectly facilitate changes in the industrial production system as well. To reach these objectives a threefold approach will be used: Networking of leading environmental research organizations in Belarus, Russia, Kazakhstan, Ukraine and Uzbekistan aimed at research cooperation and dissemination, transfer, exploitation, assessment and/or broad take-up of past and present programme results obtained by the Network members and their European partners; Support of special information-computational system opening free Internet access to thematic and general information resources in area of Environmental Sciences for professionals, students and general public thus providing an opportunity for information dissemination, continuous distant e-learning, and public awareness; Organization of multidisciplinary thematic Young Scientist Schools collocated with International conferences on Environment Sciences. Each event will give a room for a special session devoted to presentation of results of recent and ongoing FP5 and FP6 projects performed within INCO, ESD and 1ST Programmes. Recent NIS graduates and postgraduates training in modern information and computation technologies forming a backbone of Environmental Sciences at International Schools and Conferences and by means of IT and dissemination to the targeted audience information on FP6 opportunities should lead to growing a generation of researches able to assess current state of environment, to understand and prognose basic tendencies of its evolution under pressure of natural and anthropogenic processes and ready to be a part of European Research #","Environmental Observations, Modelling and Information Systems Special Support Action",FP6,30 September 2005,01 April 2004,90000.0 ENVIROMONITOR,Inel SAS,health,"This project will demonstrate a novel air quality monitoring systems, which has been developed in a previously EC funded FP7 project Nanoair. This instrument can collect the fine dust particles from the environment in real time, by using X-Ray diffraction (XRD) technology; the collected particles are analyzed qualitative and quantitatively to get detailed information on the phases present in dust, their quantity, and structural/microstructural information. This allows the activation of alarms in case hazardous breathable particles are present in the environment. The entire process is performed in the real time and therefore allows the continuous monitoring of ambient air in the industrial cities, air pollution monitoring in vicinity of industrial site, and air quality at workplaces transforming and manufacturing nanomaterials. The EnviroMonitor project will focus on a wide-range of industrial validation, performance verification against the off-site laboratory equipments 'Bench marks' to demonstrate the R&D results achieved in NanoAir. The design for efficient manufacture and disassembly will be done to reduce the cost of the assembly and comply with standards, and to achieve this we will implantation additional technical solutions. Further we will build up on the market studies we have done in the course of NanoAir project and come up with a detailed market strategy and a business plan. This system will be demonstrated in a wide range of applications, ranging from workplace transforming and manufacturing products from nanomaterials, to city administarions for traffic and industrial pollution monitoring and ambient air quality monitoring.",Demonstration of an on-site Automated Environmental Monitoring Instrument for real-time detection of hazardous air born particles and Activation of alarms,FP7,30 September 2013,01 October 2011,619240.0 ENVIRONBOS,University of Turin * Università degli Studi di Torino,environment,"The organic fraction of urban wastes can represent a rich source of bio-organic substances (BOS) easily available from urban facilities performing aerobic or anaerobic biodegradation of biomass residues; they may provide a large variety of BOS fitting a wide range of uses. The aim of the project is to explore the valorization of these residues by their use in the detoxification of other aqueous wastes. In particular, three research lines are of our interest:","Isolation, Characterization and screening of environmental applications of Bio-Organic substances obtained from urban biomasses (EnvironBOS)",FP7,09 June 2016,06 January 2011,0.0 ENVNANO,Technical University of Denmark * Danmarks Tekniske Universitet,environment,The objective of the project Environmental Effects and Risk Evaluation of Engineered Nanoparticles (EnvNano) is to elucidate the particle specific properties that govern the ecotoxicological effects of engineered nanoparticles and in this way shift the paradigm for environmental risk assessment of nanomaterials.,Environmental Effects and Risk Evaluation of Engineered Nanoparticles,FP7,11 June 2017,12 January 2011,0.0 EOTIP,Schlumberger Gould Research Center,information and communications technology,"Electrical streaming potentials are generated when water flows through many porous materials, e.g. rock. By monitoring such potentials we can learn about fluid motion during production of water/oil from reservoirs or during seismic events (earthquakes, man-made seismic shocks). Conversely, if an electric field is applied to rock, fluid can be made to flow (electro-osmosis). The physics governing streaming potentials and electro-osmosis are understood when the rock pores are filled with a single fluid. However, petroleum reservoirs often contain not only oil, but also gas or water. Thus two-phase flow is of great importance for the oil industry. Much less is known about electro-osmotically generated two-phase flow. Fuller understanding would help with the development of electroseismic techniques for O and amp; G exploration, and with techniques for monitoring the approach of water towards oil wells. This understanding will also apply to 2-phase flow in micro-mechanical (mems) devices (lab on a chip), and to the generation of electric potentials during or prior to earthquakes. The main objectives are: a) To investigate two-phase electro-osmotic flow through geometries representing the irregular pores of rock, by means of numerical computations of (1) motion of a drop through a constriction (2) motion of a train of drops, with results linked into network simulators of flow in rock pores, which have successfully predicted single-phase electro-osmotic flow. b) To expose E.Lac (the fellow) to new problems of practical importance to industry, as part of his training/career development: (1) encouraging Lac to interact with other groups within the host lab. (2) requiring him to attend weekly seminars, (3) training visits to other Schlumberger R and amp; D centres. Lac will profit from the freedom appropriate to a post-doc, whilst nevertheless guided by a senior scientist. Lacs excellent research record demonstrates that he will profit from this exposure to diverse practical",Electro-Osmotically generated Two-phase flow In Porous media,FP6,07 June 2008,08 January 2007,160860.82 EPCABO,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"Many proteins self-assemble into regular, shell-like, polyhedral structures. Protein capsids are useful, both in nature and in the laboratory, as molecular containers for diverse cargo molecules, including proteins, nucleic acids, metal nanoparticles, quantum dots, and low molecular weight drugs. They can consequently serve as delivery vehicles, bioimaging agents, reaction vessels, and templates for the controlled synthesis of novel materials. Here, we will apply our experience with protein design and laboratory evolution to extend the properties of protein containers to create practical, non-viral encapsulation systems for applications in the test tube and in living cells. Specifically, we will adapt the icosohedral cage structures formed by Aquifex aeolicus lumazine synthase (AaLS) to engineer increasingly sophisticated supramolecular complexes for use as delivery vehicles, nanoreactors and, ultimately, as bacterial organelles. Our principal aims are to: (a) tailor AaLS capsids for selective encapsulation of a broad range of macromolecular guests; (b) develop AaLS capsids as delivery vehicles for medical and imaging applications; (c) design simplified, functional mimics of carbon-fixing carboxysomes; (d) evolve redox active organelles for metabolizing aliphatic alcohols; and (e) engineer artificial organelles for the detoxification of polychlorinated phenols. We anticipate that these experiments will lead to a deeper understanding of the principles underlying the construction, function and evolution of natural protein microcompartments. At the same time, they will establish powerful strategies for creating tailored assemblies for practical applications in delivery and catalysis.",Engineered Protein Capsids as Artificial Bacterial Organelles,FP7,28 February 2018,01 March 2013,1889200.0 EPICSTENT,National University of Ireland Galway,health,"An industry-academia collaboration is proposed wherein two industry and three academic partners will establish a lasting, inter-national partnership for transfer of knowledge in biomaterials engineering. The partners have synergistic competences in the medical device sector, and, aided by a schedule of staff secondments and networking events, their relevant niche expertise will be shared and transferred intersectorally. In all 16 researchers will be supported. Coronary artery disease accounts for two million deaths per year in Europe. The long-term outcome for patients is poor: 15% die or experience re-infarction within 30 days of initial diagnosis, while over 30% are re-hospitalised within 1 year. The estimated cost to the EU economy is €192 billion/year. The over-riding S&T objective of this collaboration is to develop a biomimetic cardiovascular stent prototype, by surface functionalisation with human antibody fragments, for improved coating by epithelial precursor cells in vivo. Sophisticated protein engineering and (nano)materials analysis from academic partners will interface with focused manufacturing and market experience of industry partners to deliver a stent with improved biocompatibility, reduced re-narrowing of arteries and superior clinical performance. Partners in interventional cardiology and industrial stent manufacturing will ensure clinical relevance and market-driven focus throughout design, development and post-project market entry. The collaboration will develop skill sets of individual researchers, strengthen research capacity at partner institutions and support important extant biomedical device clusters in Ireland and Poland. The clinical end product will significantly improve patient outcomes and quality of life for Europe's citizens; reduce costs for health care providers; and strengthen the European biomedical industry, leading to creation / retention of wealth in Europe and job creation in the European medical devices sector.",Antibody-functionalised cardiovascular stents for improved biocompatibility and reduced restenosis,FP7,31 March 2017,01 April 2013,1024185.0 EPIXNET,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,photonics,"The leading thread of this NoE is photonic integration. The integration of complex or high performance photonic functions will become the key enabler for a cost-effective and ubiquitous deployment of photonics in a wide range of applications, including ICT, sensors and biomedical applications. The technologies needed for photonic integrated components and circuits are characterised by high investment and exploitation cost. This calls for more integration of research at an international level. Therefore the mission of ePIXnet is three-fold. The first objective is to stimulate the restructuring of the photonic integration research community from a model of independent or collaborative research towards a model of integrated research. The second is to stimulate training activities as well as integration of educational programs. The third objective is to stimulate new opportunities for photonic integration in a wide range of application domains.The NoE will contribute to the strategic objective: Optical, opto-electronic, photonic functional components and will focus on five major themes: photonic integration technology, nanophotonics, advanced semiconductor materials, ultrafast light sources and ultrafast signal processing. The network brings together most of Europe's strongest academic and industrial actors and will contribute to the quality of education and research by stimulating long lasting partnerships and by providing access to unique facilities and knowledge in the field. To this end the steering committee has selected 5 specific Facility Access Activities and 9 specific Joint Research Activities on the basis of their potential for research integration. The network will also develop an active program of exchange of researchers, of institutional collaboration agreements, web-based information exchange and dissemination etc. Furthermore the network will have an open policy to include affiliate partners in particular industrial affiliate partners.",European Network of Excellence on Photonic Integrated Components and Circuits,FP6,28 February 2009,28 August 2004,6000000.0 EPOFO,Imperial College London,health,"This project is aimed towards unlocking the properties of functional oxides such as ferroelectric (BaTiO3, BiFeO3 on SrNbxTi1-xO3/SrTiO3) and multiferroic (CoFe2O4 on BaTiO3) thin films. The need for manufacturing such thin films with tailored properties is currently growing immensely due to their potential for a wide range of applications including high frequency electronics, microwave tunable devices, and memory based devices. The key feature of these devices is the speed of tuning and the most inhibiting factor in their usability is the slow relaxation processes which are attributed to the residual polarization caused by the space charge formed due to the injection of electrons from electrodes and its trapping by defects and/or oxygen vacancies on the oxide film-electrode interface and/or inside the film itself. Currently, there is a critical demand for the development and application of characterization methods that are able to probe the physicochemical material parameters on the very local scale. To address this, an integrated multidisciplinary approach will be undertaken. State-of-art nanoanalytical electron microscopy techniques will be applied and developed to determine the films potential for the next-generation nanoscale components pertinent to microwave and memory devices. Specifically the objectives of the proposed research are (1) to investigate the structural defects/domain structure of ferroelectric/ multiferroic thin films, (2) to probe the oxygen deficiencies/vacancies at the interfaces, and (3) to experimentally identify and evaluate the space charge distributions arising from these defects. Finally, all experimental results will be weighed against theoretical predictions. Ultimately, the results of this project will elucidate the switch-ability, i.e. the inherent speed of tuning, of the materials at sub-nanometer scale, by rationalizing the role that each of the above-mentioned, critical attributes play in regulating the relaxation processes.",Electron probing of functional oxides,FP7,31 July 2014,01 August 2012,200371.0 EPOQUES,Mediterranean Institute of Fundamental Physics (MIFP),photonics,"Both electrons and photons have emerged as essential particles in our information age. Electrons interact strongly with each other and form the basis for computational architectures, while photons interact weakly and are the ideal candidates for communication. While the strength of each particle can also be viewed as a weakness, an emerging research field has focused on the fundamental physics of hybrid particles between electrons and photons. Known as exciton-polaritons, such particles can be generated in solid-state nanostructures such as semiconductor microcavites. Naturally, exciton-polaritons exhibit a mix of properties of electrons and photons and recent fundamental studies have revealed their Bose-Einstein condensation, superfluidity and a rich spin dynamics. With a range of basic physical effects now known, the potential for constructing devices from these hybrid particles has appeared, yet remains largely unstudied. Optical or electrical spin control of exciton-polaritons has a perspective for information processing, where the strong non-linear interactions between excitons could be sufficient for a complete logical functionality. Going beyond classical effects, exciton-polaritons are quantum particles and seem to be realistic candidates for quantum information processing. Unfortunately the field of exciton-polariton physics has evolved rather separately from the field of quantum information science, likely due to the difficulty in applying the most basic ideas of quantum information theory to exciton-polaritons. Namely, it is not known how to isolate exciton-polaritons as qubits (since they are bosons) such that more advanced schemes based on continuous variables are required. The aim of this project is to design and study theoretically exciton-polariton based devices. To understand the promise and limitations of these particles an interdisciplinary project between condensed matter physics, quantum optics and quantum information theory is essential.",Exciton-Polariton Optoelectronic and Quantum Employment in Semiconductors,FP7,28 February 2014,01 March 2012,185763.0 EQUIND,High School of Cachan * Ecole Normale Supérieure de Cachan,information and communications technology,"The key elements required for quantum information processing are - Low error encoding of qubits onto individual quantum systems - Storage of quantum information for times long compared to gate times - Controllable two qubit interactions forming fast quantum gates. Our candidate systems are the paramagnetic colour centres in diamond. They offer at individual spin control and at room temperature very long coherence times compared to quantum gate processing times. The primary objective of this project is to use such defects in nanostructured diamond to implement scalable quantum logic gates, with the prospect of room temperature operation. Such elements rely on electron spin splitting of ground states in specific colour centres in diamond. Read-out of the single electron spin state can be achieved through optical detection of the colour centre strong photoluminescence, which is perfectly photostable even at room temperature. An order-of-magnitude improvement of the detection efficiency is therefore of crucial importance for achieving single shot read-out of the state of the addressed spin, and is one of the main objectives of the project. Coherent single photon wavepackets are also one of the building blocks for a photon-based quantum processor. Since individual colour centres in diamond have been shown as promising single photon source, temporal coherence of the emitted single photons will be investigated. The project involves 8 groups, all leading experts in the field of diamond material processing and application of diamond to quantum information. It strongly relies on recent developments in the synthesis and processing of high purity isotopically engineered intrinsic and doped single crystal diamond, the production and functionalization of diamond nanocrystals, and methods of controlled activation of defect centres suitable for quantum computing. Such developments will also benefit to diamond colour centre based single photon sources for quantum cryptography.",Engineered Quantum Information in Nanostructured Diamond,FP6,30 June 2010,30 December 2006,1660000.0 ERA.NET RUS PLUS,German Aerospace Center * Deutsches Zentrum für Luft-und Raumfahrt,environment,,Further linking Russia to the ERA:,FP7,10 July 2020,11 January 2013,0.0 EREMON,Jožef Stefan Institute,information and communications technology,"Nanoscale integrated electronics requires building blocks with controlled functional properties. Tertiary inorganic nanowires made up of molybdenum, sulphur and iodine (MoSI) are a newly emerging class of one-dimensional objects with a straightforward, scalable synthesis. In nanoelectronics they are to date the only viable alternative to Carbon nanotubes (CNTs). Contrarily to CNTs, they are soluble in a variety of solvents and tend to be monodisperse with all nanowires of a given stoichiometry having identical electronic properties. In order to exploit the functionality of 1D materials in possible nanoelectronic devices such as single-electron or ballistic transistors, the non-equilibrium electron dynamics has to be understood. The goal of this project is a comprehensive investigation of the fast and slow electronic processes occurring in MoSI nanowires. This means applying an external stimulus to drive the electrons out of their equilibrium distribution and monitoring the relaxation processes. The focus is on light and electric fields/currents as external stimuli. Specifically the project addresses ultrafast relaxation processes, long lived excited states and the effect of electric fields. The processes will be investigated as a function of temperature (room temperature to liquid helium temperature) and excitation density. The tools for investigation will be ultrafast pump-probe spectroscopy, photomodulation and electromodulation as well as a combination of pump-probe with further modulation of parameters such as an applied field. The detection will cover the visible, most of the infrared and THz spectral ranges.",Electronic REsponse of MOlybdenum-based Nanowires,FP6,31 October 2008,01 November 2006,115084.0 ERESIN,Jožef Stefan Institute,manufacturing,"Nanoscale integrated electronics requires building blocks with controlled functional properties. In the continuous strive towards higher integration density, an alternative way of connecting transistors inside a chip is needed. Tertiary inorganic nanowires made up of molybdenum, sulphur and iodine (MoSI) provide a straightforward, scalable synthesis and easy dispersability in a variety of solvents without functionalisation or surfactants. Their connectivity to gold nanoparticles enables self-assembly of networks. To date, their conductivity is limited by energy disorder and defects. This process aims at improving the material by investigating the origin of disorder and defects. To this end, both the basic electrical characterisation as well as the study of the electronic relaxation dynamics via femtosecond spectroscopy will be performed with a spatial resolution down to the individual nanowire. Defects in isolated small nanowire bundles, single nanowires, and networks will be identified with conductive atomic force microscopy. Femtosecond pump-probe spectroscopy using a confocal microscope will be performed on the same samples in order to study the electronic processes of individual nanowires and how they change in the presence of defects and nanoparticle junctions.",Electronic Response of Single Inorganic Nanowires,FP7,10 July 2013,11 January 2008,45000.0 ERG-LIGHT,University of Trieste * Università degli studi di Trieste,health,"The general aim of this project is to gain new knowledge and a deeper understanding of novel two- and three-dimensional nanometer-sized assemblies of chromophores in terms of construction, characterization, photoinduced or electro-optical properties, molecular recognition and selective catalysis, antiviral and anticancer properties. The specific aim of this project is the construction, via a supramolecular approach, of novel photoactive multi-chromophore assemblies. The supramolecular synthetic strategy, by virtue of its modular and highly flexible nature, will allow to perform the selective variation of the components and investigate their influence on the properties of the final assemblies, while keeping at a minimum the synthetic effort. The ultimate aim of this project is the preparation of new photoactive nanosystems to be used in technological applications. The project will be developed within an extended frame of scientific national and international collaborative networks.",Multi-Chromophore Systems for Light Induced Processes and Light Triggered Devices,FP7,28 February 2011,01 March 2008,45000.0 ERIKLINDAHLERC2007,Stockholm University * Stockholms Universitet,health,"The long-term goal of our research is to advance the state-of-the-art in molecular simulation algorithms by 4-5 orders of magnitude, particularly in the context of the GROMACS software we are developing. This is an immense challenge, but with huge potential rewards: it will be an amazing virtual microscope for basic chemistry, polymer and material science research; it could help us understand the molecular basis of diseases such as Creutzfeldt-Jacob, and it would enable rational design rather than random screening for future drugs. To realize it, we will focus on four critical topics: • ALGORITHMS FOR SIMULATION ON GRAPHICS AND OTHER STREAMING PROCESSORS: Graphics cards and the test Intel 80-core chip are not only the most powerful processors available, but this type of streaming architectures will power many supercomputers in 3-5 years, and it is thus critical that we design new 'streamable' MD algorithms. • MULTISCALE MODELING: We will develop virtual-site-based methods to bridge atomic and mesoscopic dynamics, QM/MM, and mixed explicit/implicit solvent models with water layers around macromolecules. • MULTI-LEVEL PARALLEL & DISTRIBUTED SIMULATION: Distributed computing provides virtually infinite computer power, but has been limited to small systems. We will address this by combining SMP parallelization and Markov State Models that partition phase space into transition/local dynamics to enable distributed simulation of arbitrary systems. • EFFICIENT FREE ENERGY CALCULATIONS: We will design algorithms for multi-conformational parallel sampling, implement Bennett Acceptance Ratios in Gromacs, correction terms for PME lattice sums, and combine standard force fields with polarization/multipoles, e.g. Amoeba. We have a very strong track record of converting methodological advances into applications, and the results will have impact on a wide range of fields from biomolecules and polymer science through material simulations and nanotechnology.",Multiscale and Distributed Computing Algorithms for Biomolecular Simulation and Efficient Free Energy Calculations,FP7,31 August 2013,01 September 2008,992413.0 ERUDESP,Saarland University * Universität des Saarlandes,health,"The aim of the project is the development of electrochemical reactors for the manufacture of fine chemicals with dehydrogenases as a process with almost zero waste emission. The production of enantio pure compounds with high EE's can be achieved by using dehydrogenases as biocatalysts, because they express high enantio selectivity in ketone reduction, combined with broad substrate spectra by some of these enzymes. These proteins will be engineered for improved catalytic performance using the tools of molecular evolution, modelling, structure prediction, and crystallography. As these dehydrogenases typically require cosubstrate regeneration by aid of a second enzymatic reaction, we are looking for the alternative solution of an electrochemical approach for the regeneration of reduced cofactors. If all active compounds can be functionally immobilized on the electrode surface the constructed reactor would convert the educt in the input flow to the product in the output flow avoiding any contaminations. All necessary components like the mediator, the cofactor and the dehydrogenase will be bound to nano or meso structured electrodes (for increased active surface area) resulting in biofunctionalised surfaces with tailored properties at the nanoscale. Optimization of the electrode materials and surfaces, of the mediators and the required spacers as well as the surface bound dehydrogenase activities will result in electrochemical reactor moduls which can deliver enantio pure synthons for desired compounds in pharmaceutical or agrochemical applications. The obtained data will increase our knowledge on nanostructured catalysts and inorganic-organic hybrid systems. Cheap cofactor regeneration, easy product purification, high selectivity and avoidance of organic solvents will be the advantages of such processes to satisfy the demands of green chemistry in respect of environmentally friendly, flexible and energy efficient productions.",Development of Electrochemical Reactors Using Dehydrogenases for Enantiopure Synthon Preparations,FP7,30 June 2011,01 July 2008,2749909.0 ESBCO2,"United Nations Educational, Scientific and Cultural Organization (UNESCO)",health,"An increase in atmospheric CO2 derived from combustion, the rising prices of crude oil, and the diminishing supply of fossil fuels poses great challenges to worldwide sustainability. Thus, the necessity of developing greenhouse gas mitigation technologies and biobased renewable energy sources is very urgent. Microbial electrosynthesis (MES) exploits the ability of microbes to make electrical contacts with electrodes and other cells and the production of biofuels with such microbial electrosynthesis is of great interest. However, mechanisms by which microorganisms conserve energy to maintain cells and support growth when directly accepting electrons for MES from electrodes is not explored yet. Moreover, information on carbon and electron flow during CO2 reduction to biofuels at a cathode is not yet fully explored. Thus, MES needs to overcome several microbial, electrochemical and technical challenges. This IOF will contribute to the development of a cost effective alternative to current fuel production, using greenhouse gas CO2 (model pollutant) as a feedstock. This IOF will use new concepts dealing with the better understanding of electron (e-) transfer/exchange, surface engineering conductive biofilms, system biology/genomics, genomic tools, nano-networks and novel materials and practical implications of these concepts for environmental clean-up and the development of renewable energy sources.The proposed IOF will provide a tool for the EU Directive 2009/28/EC of the European Parliament and of the Council of 23rd April 2009 on the promotion of the use of renewable energy, and also falls into the category of EU climate and energy policies, and Europe Horizon 2020 strategy demanding climate and energy targets to be met by 2020 for smart, sustainable and inclusive growth. This IOF project will a investigate and develop a technology for the conversion of CO2 (greenhouse gas) into biofuels and will play an instrumental role in achieving a healthy environment.",Electrosynthesis of biofuels from gaseous carbon dioxide catalyzed by microbes: A novel approach/quest of microbe-electrode interactions,FP7,30 June 2015,01 July 2012,183658.0 ESCODNA,Aarhus University * Aarhus Universitet,health,"DNA Nanotechnology is an emerging interdisciplinary area that will underpin the development of future nanoscience-based technologies for areas such as medicine, diagnostic tools, optics and electronics. DNA nanotechnology is based on the unique self-assembly properties of DNA which allow the rational design and synthesis of complex nanoscale structures with predictable form and function. Many other materials can be integrated in such DNA structures to create highly functional nanodevices. The Marie Curie ITN EScoDNA will establish a sustainable European School of DNA Nanotechnology. By providing high quality training to young scientists, EScoDNA will improve their career prospects in both public and private sectors; it will also strengthen the competitive position of European research and industry in this promising strategic field. A network of leading European researchers, two SMEs and a major commercial research institute will work together to foster the development of a new generation of scientists with the skills required to meet future challenges in DNA nanotechnology, from fundamental science to novel applications. The training program will involve collaborative research projects, including international secondments and exchange of data through a web-based Lab-Wiki Journal, and through summer schools and workshops. The industrial partners will be integrated in the training programme, and the two SMEs will coordinate training related to the commercial exploitation of new technologies, management and entrepreneurial skills. They will also take a lead in managing the protection and commercialization of new technologies arising from research with the ITN. The programme is designed to create a pool of highly qualified researchers prepared for a wide range of careers in bionanotechnology and nanofabrication and, especially, capable of contributing to the development of a strong European centre for the scientific and commercial development of DNA nanotechnology.",European School of DNA Nanotechnology,FP7,31 January 2017,01 February 2013,4070204.0 ESKIN,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"Future electronic systems will be soft and elastic. I propose to explore the materials, technology and integration of stretchable electronic systems, which will transform at will, evenly coat a spherical lens, or smoothly interface with a delicate biological organ. Electronics will be anywhere as well as everywhere. The proposed programme has the potential to emulate yet another revolution in the microelectronics industry and trigger transformations in the biomedical sector. The ESKIN programme is an ambitious and highly interdisciplinary endeavour requiring expertise at the frontier of engineering, material sciences, biotechnology and neuroscience. Stretchability in an electronic system is its ability to negotiate mechanical deformations without letting them interfere with its electrical functionality. This is a novel and challenging demand on electronic device technology, which has, to date, mainly pushed for smaller scale fabrication and increased performance. Furthermore the natural compliance of biological tissues and cells calls for softer electronic biomedical interfaces. Overcoming the hard to soft mechanical mismatch will, without doubt, open up new horizons in biomedical research and its related industries. The manufacture of stretchable electronic skins will then require working out the underlying science and technology for active device materials on soft, elastic substrates. This capability will further be implemented to demonstrate various soft and elastic electronic systems ranging from stretchable displays to long-term neural implants. My philosophy is to exploit as much as possible current micro/nanofabrication techniques available for hard surfaces but to tailor them to soft surfaces, optimizing and improving them where needed, in order to ensure rapid transition to worldwide distributed consumer and healthcare products.",Stretchable Electronic Skins,FP7,29 February 2016,01 March 2011,1499737.0 ESONN,Joseph Fourier University * Université Joseph Fourier,information and communications technology,"Grenoble will organize a European School on Nanosciences and Nanotechnologies for four years. On a yearly basis, a three-week program will be set up, during which students attend both lectures and hands-on laboratories. The aim of this training is to offer young researchers a structured view of the principles at work in the elaboration and in the functioning of nano-structures, nano-components and nano-machines. This program is endowed with two key points. The first is interdisciplinary, since research in Nanosciences and Nanotechnologies demands a combination of various skills in physics, in chemistry and in biology. The second point emphasizes the role of the laboratories courses. This is a determining factor both for basic science and for applications. This implies that we treat the corresponding specific elaboration techniques, the physical and molecular mechanisms of elaboration and the instrumental skills necessary for research in the nano-world. Two options will run in parallel. The first concentrates on electronic nanostructures as building blocks of solid state or molecular electronics devices (Mesoscopic physics, spintronics, molecular electronics, single electron effects, nano-devices and nano-mechanics). The second focuses on recent advances in nanobiotechnologies (biochemistry, surface physico-chemistry, single molecule spectroscopy, mechanics of molecules, microfluidics and bio-sensors and high flux analysis data treatment). Both sessions share common lectures (nano-chemistry, nano-fabrication and near-field microscopy). The participants spend seven working days in clean room facilities and in research laboratories. The present project will comprise events, similar to the first session of the school taking place in August 2004.",European School on Nanosciences & Nanotechnologies,FP6,31 December 2008,01 January 2005,611851.0 ESRCN,Technical University of Denmark * Danmarks Tekniske Universitet,energy,"Heterogeneous catalysis is an area where nanotechnology is present in people's everyday lives. Catalytic processes are found in diverse applications such as fuel-refining, the petrochemical industry, fertiliser production, automotive catalytic converters, biochemistry etc. They also provide a pathway to renewable, clean energy in the form of hydrogen fuel cell technology. Most modern catalysts take the form of catalytically active nanoparticles dispersed over some highly porous support medium. It is expected that the activity of these particles is largely determined by the density of catalytically active sites on the particle surface. The proposed research will establish a new methodology in nanocatalyst research by using high-resolution experimental techniques to establish a close and unambiguous correlation between the morphology and reactivity of individual nanoparticles. The principal tools will be scanning tunneling microscopy (STM), which offers atomic-scale structural resolution, combined with scanning Auger microscopy (SAM), offering nanometer-scale chemical information. These techniques will be used to measure the surface structure and composition of catalytic nanoparticles before, after and perhaps even during a reaction and to correlate this data with the reactivity of the nanoparticles measured by temperature programmed desorption (TPD). By measuring the surface structure of individual nanoparticles it will then be possible to make a direct comparison with the results of computational modeling. This will open the possibility to optimize the nanoparticle size and shape in order to maximize the number of catalytically active surface sites, while minimizing the unused volume, thereby improving the efficiency of the catalyst while reducing the material cost.",Effect of structure upon the reactivity of catalytic nanoparticles,FP7,31 March 2010,01 April 2008,290980.0 ESRISCOM,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,health,"The study of strongly correlated materials dominated the second half of the last century. The not exhaustive list of such materials and phenomena - where strong correlation effects give rise to unique behaviour - include superconductors, Mott-Hubbard insulators with magnetically ordered ground states, materials with density wave ground states, and materials with more exotic states such as the Tomonaga-Luttinger liquid state. Understanding the fundamental phenomena behind strong correlation effects have motivated numerous theoretical work, which has greatly affected the way many body quantum mechanical systems, and in particular condensed matters, are understood. On the applied side, this has contributed to a range of novel materials that has revolutionized the today's world. The application of strongly correlated materials ranges from space research through electronics and military applications till medicine. Given the importance of the phenomena occuring for strongly correlated materials, further investigation of such systems is highly desired. The emerging new materials that are desired to be investigated are carbon nanostructures, and novel superconductors such as MgB2 and organic superconductors. Here, the improvement of electron spin resonance instrumentation available at the host is proposed together with detailed study of these systems. The instrument will be dedicated to the research of these systems, however, it will also be offered part-time for other studies such as chemical systems and biological compounds. Thus, the proposal contributes to a wider area of research beyond its primary use. This is particularly important as the host is situated in a less developed region of the EU and it will also be beneficial for the reintegration of the applicant. The applicant will combine the experimental method that he was originally mastering before the Marie-Curie EIF with the training activities that he has acquired during the fellowship.",Electron spin resonance spectroscopy in strongly correlated materials,FP6,31 December 2006,01 January 2006,40000.0 EST-FRAME,Oslo and Akershus University College * Høgskolen i Oslo og Akershus,energy,"The aim of the EST-Frame project is to contribute to socially robust and ethically sound research and technology development by providing further methodological development of appropriate tools for social impact assessment and technology evaluation. The project will appraise current assessment methods for evaluating emerging science and technology with the objectives of mapping their strengths and weaknesses and determining their appropriate application domains. It will examine the current policy context for emerging science and technology (EST) policy advice and will identify future trends and needs that should be considered. The project will, in close dialogue with end users, also identify to what extent -and in what contexts –a framework of a more integrated nature can be applied, and it will examine the appropriate position that such an integrated framework can operate in, within a context characterised by internationalisation, market politics, and new forms of public-private partnerships in technology governance. Finally, this work will result in the design of a flexible, integrated framework that is intended to facilitate holistic societal dialogue and reflection and policy advice on emerging science and technologies. This integrated framework can be applied by policy forming actors (economic councils; ethical councils; technology appraisal institutes, government technology assessment boards, etc.) who are involved in the process of conducting analyses and coordinating policy deliberations on the broad range of science and technological developments. The project will use four examples of emerging science and technologies -(1) nanotechnology in food production, (2) synthetic biology, (3) biofuels and (4) security in emerging ICTs -to determine how current frameworks are applied to assess social impacts and then evaluate these assessments in light of the integrated framework. An added value of the project is policy relevant advice on the four cases.",Integrated EST Framework,FP7,31 December 2014,01 January 2012,1499273.0 EST3,Politehnica University of Bucharest * Universitatea Politehnica din Bucuresti,information and communications technology,"'Politehnica' University of Bucharest provides a multidisciplinary research training program within EST mono-site, where several research groups having best research merits, from different departments such as: mathematics, computer science, electrical, bio and mechanical engineering, offer joint structured training on various advanced aspects of Computational Science and Engineering (CSE). It provides to the hosted ESRs the necessary theoretical and scientific background for an advanced research project in nano-electronics. The training combines expertise in large size numerical modeling, high performance computing techniques, coupled multi-physic modeling/design, optimization and inverse problems. The project is going to be laboratory based, since the entire training is project oriented, based on comparison between simulated and experimental results in several engineering areas. The program provides EST fellows complementary courses such as: scientific project management, or professional communications. Opportunities are offered for 6 researchers to carry out PhDs (three years stay), as well as 12 placements for short stays (four month each), aiming to obtaining joint degrees, using ECTS as our traditional European partners. The research component is carried on in synergy with other European research or training projects. It aims to the development of new and powerful tools and methodologies for nano-electronic design automation.",Early Stage Research Training in an Eastern European Site with Tradition in Computational Science and Engineering,FP6,31 October 2009,01 November 2005,744229.99 ET DPHEN DNA,University of Bern * Universität Bern,health,Synthesis and development of novel DNA base pairs that are orthogonal in their recognition properties compared to the natural base pairs are avidly pursued by scientists. Such novel base pairs are investigated as tools in biotechnology and in designing novel genetic systems. Interest in artificial base pairs continues because of their application in materials research and nanosciences. Likewise charge transfer (CT) through the DNA duplex has received considerable attention and is being explored in fundamental and applied research. The objective of this project is to synthesize and study DNA containing more than one phenanthrenyl-pair (dPhen-R) in a duplex DNA. This would provide the first example of electron transfer through a duplex containing multiple phenanthrenyl (dPhen-R) base replacements. Substitutions (R) on the ring will influence the redox potential of the aromatic system. This will also influence the electron transfer efficiency. This project will also pursue the synthesis of a base-pairing nucleobase analogue capable of acting as an electron acceptor. This electron acceptor will report on electron transfer by a fluorescent response and increase the stability of the duplex. The optimized DNA-based architecture will then be attached to a gold surface in order to observe direct electron transfer by nanoelectrochemistry. It is envisioned that this novel DNA architecture and future designs may be applied in DNA based biosensors and in the area of DNA nanomaterials.,Electron transfer through multiple consecutive phenanthrenyl containing DNA,FP7,31 July 2011,01 August 2009,181935.0 ET4US,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),information and communications technology,"Silicon CMOS is rapidly running out of steam and the entire semiconductor industry is puzzled about what comes next as the roadmap advances towards the terahertz region. It is clear that virtually every material (gate, gate oxide and channel) used in the current transistor must be replaced within the next 3 - 4 years, without interruption in the industry's pace. Two high mobility material classes are emerging as potential silicon replacement: germanium (Ge) and compound semiconductors (CS). The goal of this project is to find out which one presents the best future technology platform. This formidable question requires a major rethinking of all materials and processes. It will be addressed here from all relevant aspects: advanced large area wafers, novel gate stacks and transistor processing. With a strict focus on a simple and well defined process-flow as well as an innovative, fast materials characterization track, the main strengths and show-stoppers for each material system will be identified.The first objective is to demonstrate that high mobility large area compliant substrates of Ge-on-insulator (GOI) and CS- on-insulator (CSOI) can be obtained. GOI, and CSOI will be grown by developing a 'strained oxide template on Si' technology based on molecular beam epitaxy (MBE). The second objective is to demonstrate high quality gate stacks on Ge and CS. The challenge is to find suitable high-k compounds that can be used as gate dielectrics while maintaining high channel mobilities. The development of amorphous or epitaxial (for double gate) metal gates are also an essential project component.The third objective is to integrate the new channel and gate materials with a 200 mm semiconductor wafer processing line to demonstrate high mobility transistors for a few well chosen material systems.",Epitaxial Technologies for Ultimate Scaling,FP6,30 June 2007,30 December 2003,3727000.0 ETASECS,Technion Israel Institute of Technology,energy,"ETASECS aims at making a breakthrough in the development of photoelectrochemical (PEC) cells for solar-powered water splitting that can be readily integrated with PV cells to provide storage capacity in the form of hydrogen. It builds upon our recent invention for resonant light trapping in ultrathin films of iron oxide (a-Fe2O3), which enables overcoming the deleterious trade-off between light absorption and charge carrier collection efficiency. Although we recently broke the water photo-oxidation record by any a-Fe2O3 photoanode reported to date, the losses are still high and there is plenty of room for further improvements that will lead to a remakable enhancement in the performance of our photoanodes, reaching quantum efficiency level similar to state-of-the-art PV cells. ETASECS aims at reaching this ambitious goal, which is essential for demonstrating the competitiveness of PEC+PV tandem systems for solar energy conversion and storage. Towards this end WP1 will combine theory, modelling and simulations, state-of-the-art experimental methods and advanced diagnostic techniques in order to identify and quantify the different losses in our devices. This work will guide the optimization work in WP2 that will suppress the losses at the photoanode and insure optimal electrical and optical coupling of the PEC and PV cells. We will also explore advanced photon management schemes that will go beyond our current light trapping scheme by combining synergic optical and nanophotonics effects. WP3 will integrate the PEC and PV cells and test their properties and performance. WP4 will disseminate our progress and achievements in professional and public forums. The innovations that will emerge from this frontier research will be further pursued in proof of concept follow up investigations that will demonstrate the feasibility of this technology. Success along these lines holds exciting promises for ground breaking progress towards large scale deployment of solar energy.",Extremely Thin Absorbers for Solar Energy Conversion and Storage,FP7,31 August 2019,01 September 2014,2150000.0 ETHENTECH,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"The main objective of this ETHENTECH project is to take substantially further forward both the ethical evaluation and public discussion of two important emerging fields of micro- and nanobiotechnology which pose very significant ethical and societal issues of public concern: neurological implants and the potential for human functional enhancement. Neural implants are a major new class of medical devices, which create an interface between nerve tissues and nano- or micro-scale probes. The aim is to enable a patient's nervous system to communicate with new devices that replace or supplement a malfunctioning organ, for example to restore hearing or eyesight or to treat degenerative diseases like Parkinson's. Human functional enhancement technology refers to a wide range of converging technologies which have the potential to enable significant modification of the systems of the human body, beyond what might be seen as medical purposes. The subjects of the ETHENTECH project address some of the most far-reaching fields among new and emerging technologies today - in terms of their potential social impact and the challenges these will pose to ethical issues and values of European citizens and societies. The project's two fields of implant and human enhancement technologies both lack ethical frameworks and European and international guidelines. This absence reflects the emerging and complex nature of both areas. They also represent cases where issues of dual use are a significant and further complicating factor. While several EC and other projects have given useful overviews of the ethical terrain, it is clear that there is now a pressing need to engage in more depth with particular issues in order to focus ethical frameworks and guidelines around particular issues.",Ethics of enhancement technology,FP7,30 June 2012,01 July 2009,499889.0 ETP-SC,European Chemical Industry Council * Conseil Européen de l'Industrie Chimique AISBL,environment,"Innovative chemistry will contribute largely to our innovation demands. The challenge is, in concert with other scientific disciplines, to nurture and support the required transformation of chemistry science and its industrial application, in order to deliver future options and new technologies that are intrinsically sustainable, also enabling competitiveness of the EU chemical industry. This SSA aims to support and increase sustainable chemistry innovation in Europe, by facilitating a European Technology Platform for Sustainable Chemistry (SusChem ETP). The SusChem ETP will be a multi-stakeholder activity that will involve all relevant stakeholders from e.g. industry, academia, policy makers and regulators, financial community, societal organisations. The SSA will organise general as well as expert workshops, to identify where Europe want to be with regards to sustainable chemistry in the next 15-20 years (vision paper), what science gaps and barriers exist to reach that vision (Strategic Research Agenda, SRA), how to fill the science gaps by means of collaborative R&D, both on European and national levels, and how to remove the barriers to sustainable chemistry innovation (SRA implementation plan). An extensive communication plan will ensure engagement and open communication with stakeholders. The SSA will make a significant contribution to the EU's 'Lisbon' and 'sustainable development' strategies. The SusChem ETP work will be framed within established EU policy with respect to the Framework Programmes, Sustainable Development, Biotechnology and Nanotechnology, Materials and Processes' priorities. Several themes are directly contributing to the Environmental Technologies Action Plan (ETAP) and the European Strategy for Environment and Health. The SSA is about setting up the SusChem ETP and will put in place the processes by which progress will be monitored and plans and policy recommendations are revised, in future years beyond the duration of the SSA.",A European Technology Platform for Sustainable Chemistry,FP6,31 March 2007,01 January 2005,784998.0 ETRAPCO2,University of Nottingham,health,"The development and utilization of new technologies using supercritical carbon dioxide (sc-CO2) makes them quite attractive their using in new nano-electronic devices and understanding of novel mechanisms for drug transfer in human organism. The main purpose of this proposal is the theoretical study molecular complex formation in sc-CO2 solutions induced by their interaction with low energy electrons, that leads to a weak electron localization. As a main tool for the theoretical treatment of these systems we will use Car Parrinello molecular dynamics (CPMD). The systems to be considered are of importance both from the fundamental as well as practical viewpoints because of their using in the preparation of functional components for nano-electronic devices and for selectively removing metals (actinides) from contaminated surfaces. Studies of electron attachment to van der Waals clusters can be particularly useful from point of view that they can be considered as nanoscale prototypes for investigation of the effects of solvation on the characteristics of both solvent and solvated particles, due to the interaction between a solvated molecule or ion and its surrounding solvent environment.",Electron self trapping in supercritical CO2,FP6,22 November 2008,23 November 2006,153376.28 ETRAPCO2,"Heat Physics Department, Uzbek Academy of Sciences",health,"The development and utilization of new technologies using supercritical carbon dioxide (sc-CO2) makes them quite attractive their using in new nano-electronic devices and understanding of novel mechanisms for drug transfer in human organism. The main purpose of this proposal is the theoretical study molecular complex formation in sc-CO2 solutions induced by their interaction with low energy electrons, that leads to a weak electron localization. As a main tool for the theoretical treatment of these systems we will use Car Parrinello molecular dynamics (CPMD). The systems to be considered are of importance both from the fundamental as well as practical viewpoints because of their using in the preparation of functional components for nano-electronic devices and for selectively removing metals (actinides) from contaminated surfaces. Studies of electron attachment to van der Waals clusters can be particularly useful from point of view that they can be considered as nanoscale prototypes for investigation of the effects of solvation on the characteristics of both solvent and solvated particles, due to the interaction between a solvated molecule or ion and its surrounding solvent environment.",Electron self trapping in supercritical CO2,FP6,30 November 2009,01 December 2008,39812.01 EU-DOMAIN,Innova SpA,information and communications technology,"The eu-DOMAIN project will develop a new, innovative European ambient intelligence service platform for automatic, context sensitive offering and contracting of mobile web services across heterogeneous networks. The eu-DOMAIN service platform will interconnect people, devices, buildings and content in an interoperable network. The eu-DOMAIN platform can be deployed in a broad range of industrial, government, healthcare and other citizen applications. In the project, the platform will be validated in two sectors: Building facility management and e-Health services. eu-DOMAIN supports mobility among users and workers by integrating them with seamlessly accessible ubiquitous intelligent surroundings that support self-configuring devices using semantic agents and tools for ambient awareness and decision support. eu-DOMAIN opens up for entirely new ways of working in collaborative work environments across distributed organisations by offering mobile, ad-hoc trusted services over heterogeneous universal communication lines. It supports working-out-of-workspace by providing seamless delivery-on-demand of content and establishes multimodal exchange of knowledge amongst people, machines and devices. eu-DOMAIN uses intelligent user interfaces based on context-sensitivity and automatic user profiling, tailored to the need of the mobile user. An integral part of the project is the development of realistic business models for users and service providers. The business models wll be based on the concept of value-nets and emphasis will be made on identifying value creation and new business opportunities for SME's. The platform will be available after the completion of the project to stimulate take-up. The main technological innovation in the eu-DOMAIN platform lies in its 3-tier intelligence pools based on a hierarchal client/server structure. Network, application and location intelligence is guiding interaction between service providers, fixed and mobile locations and devices.",enabling users for - Distance-working and Organizational Mobility using Ambient Intelligence service Networks,FP6,31 May 2007,31 May 2004,2380000.0 EU-RU.NET,European Centre for Knowledge and Technology Transfer (EUROTEX),information and communications technology,"A large number of leading European and Russian scientists led by the Vice-President of the Russian Academy of Sciences Nobel Laureate Professor Zhores Alferov, credited “for basic work on information and communication technology” – the invention of heterotransistor and the first double heterostructure laser diode to achieve continuous wave operation, have come together in this project with the sole purpose of strengthening the EU-Russia cooperation in Nanoelectronics Technology. This is in line with the EU strategy of deepening and broadening the international aspect of its science and technology policy. Cooperation with Russia is an important part of it, and today a great leap forward has taken place by proposing a linkage between EU and Russian strategies for the development of Nanoelectronics Technology – an essential element for keeping European industry competitive at global level.","Linking R&D Strategies, Foresight and Stimulation of EU-Russia Cooperation in Nanoelectronics Technology",FP7,06 June 2014,05 January 2010,0.0 EUCARBON,Institute of Mechanical Engineering and Industrial Management * Instituto de Engenharia Mecânica e Gestão Industrial,transport,"EUCARBON project aims to overcome the present recognised need of European made space qualified carbon fibre and pre-impregnated materials (prepregs). These materials are the building blocks for technological innovation in Space research. Presently aerospace qualified carbon fibre is either produced outside Europe or produced in Europe under foreign countries supervision. This issue weakens European competitiveness in Space. Therefore, the possibility for Europe to have free, unrestricted access to these materials requires their development in European facilities under European supervision.",European Space Qualified Carbon Fibres and Pre-Impregnated Based Materials,FP7,11 June 2016,12 January 2011,0.0 EUDEVLAS,Council for Scientific and Industrial Research (CSIR),environment,"The EU has the goal of becoming 'the most competitive and dynamic knowledge-based economy in the world' in order to achieve secure employment in conjunction with environmental sustainability. To this end, it is concluded in MANUFUTURE a vision for 2020 that concerted effort is needed in order to provide European manufacturing with high quality and easily accessible research, technological development and innovation infrastructures. For this purpose, the EUDEVLAS project offers the synergies which can be obtained at international level with respect to specifically Developing Countries as foreseen in activity 3.4.5.3: Cooperation with Third Countries in the field of nanotechnology, advanced multi-functional materials and new ways of production research. The three leading nations among the Developing Countries - South Africa, India and Brazil - are already engaged in innovative research in Laser Processing. Such research is driven by the increasing realisation of the value of R and D in economic development as well as the need to establish competitive manufacturing industries. This is happening at a time when new laser sources are coming to market and it appears possible that Developing Countries may leapfrog the EU in some applications of Laser Processing. A comprehensive exploration is planned of all aspects of common interest between the EU and Developing Countries in the field of Laser Materials Processing to establish appropriate contacts and identify areas of potential synergy. The mapping of current and future fields of common interest will lead to the establishment of effective and lasting international Teams of Excellence in Advanced Laser Materials Processing which can add real value at a European level. These Teams will be managed to develop innovative research project proposals in response to the priorities of FP7.",European Union-Developing Countries Laser Processing Initiative,FP6,31 October 2008,01 September 2006,200000.0 EUKARYOTIC RIBOSOME,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"The ribosome is a large cellular organelle that plays a central role in the process of protein synthesis in all organisms. Currently, structural information at atomic resolution exists only for bacterial ribosomes and some of their functional complexes. Eukaryotic ribosomes are larger and significantly more complex than their bacterial counterparts. They consist of two unequal subunits with a combined molecular weight of approximately 4 million Daltons and contain 70-80 different protein molecules and four different RNAs. Currently the only structural information on eukaryotic ribosomes is available from cryo electron microscopic reconstructions in the nanometer resolution range, which is insufficient to derive information about the function of the eukaryotic ribosome at the atomic level. The aim of this proposal is to use X-ray crystallography to obtain structural and functional information on the eukaryotic ribosome and its functional complexes at high resolution. The key targets of the structural work will be: i) the structure of the small ribosomal subunit, ii) the structure of the large ribosomal subunit, and iii) structures of complexes involved in the initiation of protein synthesis. Besides the obvious fundamental importance of this research for understanding protein synthesis in eukaryotes the proposed studies will also be the prerequisite for understanding the structural basis of the regulation of protein synthesis in normal cells and how it is perturbed in various diseases. Finally, comparing the structures of bacterial and eukaryotic ribosomes is important for understanding the specificity of various clinically used antibiotics for the bacterial ribosome.",Structural studies of the eukaryotic ribosome by X-ray crystallography,FP7,30 June 2015,01 July 2010,2446725.0 EUPHONON,IMEP-LAHC Laboratory,information and communications technology,"The aim of this project is to amalgamate the existing and future activities on phonon science and technology in Europe to establish a strong community in this emerging research field. The impact of EUPHONON will extend from academia to ICT-related industry by providing means for thermal management, optimisation of data handling and, in longer term, new methods for material characterisation and new paradigms for information processing. EUPHONON will set the definition for the phononics science and manifest the crucial goals in solid state physics, nanoelectronics and in bioscience in which the role of phonons has been overlooked. EUPHONON will create intimate collaboration between the various research fields, including theory, modelling, computation, information technologies and experimental science. A position paper on the importance and role of phonons will be one of the main outcomes of the project together with a research agenda, which could become the basis to guide, advance and prioritise the focii of the research resources in this field.",Building a European NanoPhononics Community,FP7,10 July 2016,11 January 2013,393972.0 EUROMBR,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The objective is to deliver a trans-European network of industrially oriented specialists fully trained in the development and application of microbioreactor (MBR) technology to support development of innovative bio-based manufacturing processes. The specialistis will be trained by leaders in the field and with state of the art equipment and methodologies. MBRs are a promising tool for screening and scale-up of fermentation and biocatalysis processes due to their low production cost, small working volumes, flexibility and their potential for information-rich experiments under well-controlled experimental conditions. In this consortium, we will further develop MBRs for chemical and biochemical screening, paying special attention to MBR parallelization and applicability for different applications. In addition, characterization of experimental uncertainty, development of reactant feeding strategies at micro-scale and coupling of microscale experimentation to automated design of experiments (DoE) will document applicability of MBRs for chemical and biochemical research. To enhance the applicability of microfluidic enzymatic reactors for organic synthesis, we will establish microfluidic chemo-biocatalytic reaction systems that enable rapid characterization of biosynthetic pathways and chemo-enzymatic conversions. This will be underpinned with immobilization methods that permit rapid and reversible binding of a range of biocatalysts and modeling that relates the kinetic data with results from larger scales. Complemented with precisely positioned fluorescence-based sensor arrays, novel nanosensor particle concepts, and integrated Raman and NIR probes, the MBRs will deliver the data-rich experimentation needed for industrial applications. Data processing and information management will be accomplished by developing CFD and mathematical modeling methods that permit prediction and interpretation of fermentation and biocatalytic processes in MBRs.",European network for innovative microbioreactor applications in bioprocess development,FP7,31 October 2017,01 November 2013,3983056.0 EUROMEMBRANES,Centre for Materials and Coastal Research * Helmholtz-Zentrum Geesthacht – Zentrum für Material- und Küstenforschung GmbH,health,"This proposal plans a series of 5 events on Membrane Technology. Membranes have established applications in the food, petrochemical and pharmaceutical industry, water desalination, medical processes like hemodialysis and has gain an increasing relevance in the field of renewable energy.1. Conference ¿New Materials for Membranes¿ (to be organised by GKSS research centre in 2007). The idea is to integrate new advanced materials in the membrane technology, bringing new breakthroughs in the field. Three summer schools are planned with the character of training, enabling young scientists to benefit from the experience of leading researchers: 2. Summer School ¿Smart Materials¿ (to be organized by IMC/ICT Prague in 2006)will give an insight on fundamental aspects of membrane preparation using self-assembly, nanocomposites and other new materials for separation techniques and energy. 3. Summer School ¿Membranes for reactive processes¿ (to be organized by the University of Genoa 2007) will include membrane preparation, characterization and application in fuel cells and catalytic membrane reactors. 4. Summer School ¿Solvent resistant membranes¿ (to be organized by the Catholic University of Leuven in 2008) will focus on applications in the chemical and pharmaceutical industry. 5. Workshop ¿Advances in Membrane Technology¿ (to be organized by GKSS in 2008)will focus on different aspects of membrane technology, presented mainly by highly qualified women scientists in the membrane field, stimulating the participation of young female students. The workshop will have a practical part with technical machines for membrane preparation and characterization, module manufacture, etc and will offer lectures on how to develop skills in communication, meeting moderation, project preparation.The coordination will be in charge of GKSS and will have a narrow interaction with the Network of Excellence NanoMemPro and the European Membrane Society for publicity and selection.",European Conferences and Training in Membrane Technology,FP6,31 March 2010,01 April 2006,261700.0 EURONANOMED,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"Nanomedicine is an emerging field with a large potential for developing public welfare and economic growth. Critical issues for bringing up this potential in Europe concern especially the maturity of the economic players and their capability to move effectively innovation from knowledge to industrial technology and to clinical and public health applications. Industrial players need therefore to collaborate closer with scientific partners and with clinicians. The second issue is the ability of companies to establish multidisciplinary networks with the research and the clinician communities, increasing their efforts towards biological preclinical and clinical validations. This will shorten the delay for patients to benefit from the innovation and increase the competitiveness of European actors. Therefore EuroNanoMed targets the creation of a mechanism to support trans-national collaborative RTD projects between academic laboratories, companies, especially SME's, and clinicians/public health setting, in the field of Nanomedicine, using a bottom up approach. In consequence, EuroNaNoMed will develop coordinated European-wide programmes based on common joint transnational calls and funding. The thematic of these two calls will focus on the strategic research priorities of the European technology platform 'Nanomedicine': diagnostics, targeted delivery and regenerative medicine. EuroNanoMed achieves an effective critical mass: the 19 participating national/regional programmes expect to dedicate significant budget to the calls, approximately 15-20% of the sum of their national/regional Nanomedicine budgets. The Long Term Vision of EuroNanoMed is the design of a European-wide integrated programme with a coordinated funding. Potential scenario for implementation will be suggested.",EUROpean network of trans-national collaborative RTD in the field of NANOMEDicine,FP7,31 December 2011,01 January 2009,1332494.0 EURONANOMED II,National Research Agency * Agence Nationale de la Recherche,health,"Nanomedicine, the application of nanotechnology to health, is a fast-growing field with a large potential for improving diagnostics and therapeutic solutions in many diseases. The EuroNanoMed II (ENM II) consortium, with 20 partners from 17 countries and regions, aims to foster the competitiveness of European nanomedicine actors through the support of translational research projects enhancing transnational and multidisciplinary collaborations between academia, clinical/public health communities and industry. ENM II will be a follow-up of the ERA-NET EuroNanoMed I (ENM I), which launched three joint transnational calls for proposals in three years. The increasing number of submitted proposals in the successive ENM I joint calls and their quality show the need amongst the nanomedicine scientific community for such a targeted initiative. ENM II will be built on the basis of the ENM I accomplishments, and will continue to support transnational innovative RTD projects in nanomedicine through the launch of yearly joint calls for proposals. In addition, ENM II aims to extend the cooperation among its partners through the development of other activities: (i) foster the participation of young European researchers to ENM II activities; ii) develop a strategic agenda for ENM II in close cooperation to the ETP Nanomedicine; iii) create more interactions within the European nanomedicine community and improve communication on nanomedicine to the public; iv) frame and address regulatory, safety and ethical issues associated with nanomedicine; v) monitor the results of the ENM I & ENM II funded research projects and the activities of the ENM II network; and, vi) develop a long-term cooperation framework for European nanomedicine research. Therefore, through joint funding of translational nanomedicine projects and its other activities, ENM II will contribute to enhance coordination of research and resources in this field, thereby shaping the European Research Area in nanomedicine.",EUROpean network for transnational collaborative RTD projects in the field of NANOMEDicine,FP7,31 October 2016,01 November 2012,1499990.0 EUROPRACTICE IC3,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"This project is submitted to continue the current Europractice IC Service. The Europractice IC Service has been established in 1995 with EC funding. Over the years more and more universities and research institutes from the `extended¿ Europe have become Europractice member and are purchasing CAD tools and IC prototype fabrication from the Service. Today more than 550 European universities and 50 research institutes are using the EP Service. The objectives are offering access to CAD tools for learning/research and access to advanced IC technologies for prototyping. The users are able to buy CAD tools and IC/MEMS/SIP prototype fabrication and get technical support both on the use and installation of CAD tools and on the ASIC/MEMS/SIP technologies and design kits. Under the current IC Service, CAD tools for MEMS design are already offered. In the proposed continuation of the Service, the IC service will be extended with prototyping possibilities in a few selected MEMS and SIP technologies in order to offer universities possibilities for heterogeneous SoC design. On the longer term this will lead to integrated (and intelligent) CMOS MEMS solutions and full SoC solutions. As a broker, Europractice negotiates low cost conditions with the most popular industrial-standard CAD vendors for cheap university and research institute licenses for educational/research use. Europractice coordinates and combines monthly purchase orders from all the universities and research institutes, distributes and supports those tools. Every year all of those 600 institutes rely on the Europractice IC service in order to have their annual CAD licenses renewed (by paying annual maintenance fees). Europractice has negotiated with several ASIC foundries agreements and buy or share low cost MPW (Multi Project Wafer) runs in order to offer low cost prototype possibilities to universities and research institutes. This will be extended with offers from the major European MEMS foundries.",EUROPRACTICE CAD and IC Service for European universities and research institutes,FP6,31 December 2009,31 December 2005,4700000.0 EUROSAINT,STMicroelectronics SA,information and communications technology,"EUROSAINT's objective is to support the work of the Technology Platform on Nanoelectronics, to define future research agendas, by promoting and consolidating the European Nanoelectronics Initiative Advisory Council (ENIAC), which is the governing body of the Platform. By bringing organisational and operational support to further develop and subsequently implement the strategic vision of the Nanoelectronics Technology Platform, the project will allow large and small industry, research organisations, public authorities, financial institutions and other stakeholders across the EU to join forces and coordinate their actions for the elaboration and implementation of the Nanoelectronics Strategic Research Agenda (SRA). To ensure successful innovation, related structural, educational, and regulatory matters (standards, IPR, research infrastructure, training), and the creation and support of required research infrastructures will also be covered. EUROSAINT will provide a structure with dedicated resources for ENIAC to implement its mission, drive its roadmap and to achieve its goals.",EUROpean Support Action for Integration of Nanoelectronics Technology,FP6,30 June 2008,30 December 2005,962000.0 EUROSOI,University of Granada * Universidad de Granada,information and communications technology,"The EUROSOI network embraces a broad range of research areas related to Silicon-On-lnsulator technology(from materials to end-user electronic applications in traditionally strong European industrial sectors such asautomotive, communications, space). EUROSOI aims at federating the existing research work on SOI topics andat providing an appropriate communication channel between academic groups and industrial production centres.EUROSOI coordination efforts will be focused on fostering different activities to improve the lack of industrialdevelopment in Europe in SOI topics. A network of research centres, industries and end-users is the appropriatetool to structure and organize the existing RandD work on SOI topics, and achieve a critical mass to efficientlyclose the gap between academic groups and industry, which is responsible for the weakness of EuropeanIndustry with regard to SOI. Key actions to reach the above-mentioned objectives are: i)to promote interactionbetween scientists, ii)to take advantage of the previous experience of research groups, iii)to join forces tomaximize the synergy between individual skills, thus obtaining the best achievable global results, and iv) toprovide an appropriate communication channel between academic groups and industrial production centres.EUROSOI will contribute to this by: a)The exchange of information during the workshops organized by thenetwork. (b)Scientific exchange between partners by research visits of scientist and student grants, (c) A web-based database on work by SOI containing: news, resources, project results, reports, links, seminars, training,courses, job opportunities, grants, (d) Elaboration of the European SOI Roadmap: identification of scientificpriority areas and formulation of research and development strategies, (e) Elaboration of Who is Who Guide inSOI.","Thematic Network on Silicon on Insulator Technology, Devices and Circuits",FP6,17 March 2006,17 December 2003,368000.0 EUROTALENTS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),environment,"CEA is convinced that the ability of research institutes to offer attractive working conditions and career opportunities to researchers is a key factor in meeting the challenge of maintaining and boosting Europe’s scientific and economic competitiveness. Thus, thanks to the European Commission cofunding, CEA would like to develop a centralised programme dedicated to researchers’ transnational mobility and based on open merit competition and international peer review. This programme called ‘Eurotalents programme’ will aim at increasing the mobility of scientists and at offering a boost in their career thanks to the access to new research capacities. Eurotalents will open world class laboratories within CEA and abroad to researchers having an excellent scientific experience and wanting to broader their career via a research project in the scientific topic(s) of their choice within CEA well-known domains of expertise: (i) Energy, environment and climate change, (ii) Life sciences and biotechnology, (iii) Nanosciences and nanotechnologies, (iv) Science and technology of high performance computing, (v) High energy physics and physics of the universe. Eurotalents will thus offer fellowships to foreign researchers wanting to work in CEA (Incoming fellowships) or to French scientists aiming at developing their scientific career abroad (Outgoing fellowships). The selected researchers will also benefit from CEA network all over the world and have access to training courses in scientific and non scientific disciplines. Eurotalents will be directly operated by CEA that has already proved its capacity to efficiently manage European projects and national programmes according to strict rules Eurotalents will exploit synergies between UE actions, CEA research facilities and scientific environment, and CEA quality of work. Thus, Eurotalents will contribute to the success of the European Research Area by attracting third country researchers and promoting European mobility.",Eurotalents: a European programme for transnational mobility of experimented researchers managed by CEA,FP7,02 April 2015,03 January 2009,4996768.0 EUROTRAINING,Technoconsult ApS,information and communications technology,The objective of the EuroTraining proposal is to provide a European Training Infrastructure facilitating the provision of high calibre training across Europe. The structure will support professional advancement training as well as academic training. Professional course providers will get a central place for the presentation of their training offer while academics will get a course material exchange service targeting graduate nanoelectronics schools._x000d_,Provision of a European training infrastructure,FP7,10 July 2012,11 January 2007,0.0 EUROTRAINING,Swiss Foundation for Research in Microtechnology * Fondation Suisse pour la Recherche en Microtechnique,information and communications technology,"The objective of the EuroTraining proposal is to provide a European Training Infrastructure facilitating the provision of high calibre training across Europe. The structure will support professional advancement training as well as academic training. Professional course providers will get a central place for the presentation of their training offer while academics will get a course material exchange service targeting graduate nanoelectronics schools. The training action will enhance the development of the European knowledge-based society in the field of nanoelectronics. The proposal strongly builds on key building elements from the former EuroTraining project (ICT-211806), however extended with new innovative services, like:",Provision of a European Training Infrastructure,FP7,12 July 2017,01 January 2013,0.0 EUROTRAINING-MST,Swiss Foundation for Research in Microtechnology * Fondation Suisse pour la Recherche en Microtechnique,information and communications technology,The objective of the EuroTraining-MST proposal is to provide a European Training Infrastructure facilitating the provision of high calibre training across Europe. The structure will support professional advancement training as well as academic training. Professional course providers will get a central place for the presentation of their training offer while academics will get a course material exchange service targeting graduate nanoelectronics schools.,Establishment of microsystems training requirements in Europe,FP7,11 June 2012,06 January 2008,499953.0 EVOBLISS,IT University of Copenhagen * IT-Universitetet i København,health,"We will develop artificial, technological evolution and use it to design functional ecosystems consisting of up to three forms of living technology, namely, artificial chemical life, living microorganisms, and complex chemical reaction networks for the purpose of improved treatment and cleanup of wastewater for energy generation. The goals of this project are i) develop a general, robotic platform, which by using artificial evolution can optimize the performance of a physicochemical or microbial system and its environment and ii) use the robotic platform to evolve improved microbial fuel cells in terms of robustness, longevity, or adaptability. The robot evolutionary platform will take the form of an open-source 3D printer extended with functionality for handling liquids and reaction vessels, and for obtaining feedback from the reaction vessels either using computer vision or task-specific sensors in real-time. The robot platform will optimize parameters such as the environment, hydraulics or real-time interaction with experiments (for instance, timing of injection of nutrients, removal of metabolic products, stirring, etc.) to maximize a desired functionality. Initially, we investigate processes such as fluid-structure-interaction driving bio-aggregate structure and in turn metabolic activity as well as the interaction of nanoparticles and bacterial cells by analyzing the outcome of the evolutionary process using state-of-the-art imaging techniques. We then seek to exploit synergies between these technologies to significantly improve the ability of the living technology, in the form of optimized microbial fuel cells, to cleanup wastewater. Overall, this is a cross-disciplinary project involving state-of-the-art chemistry, imaging, robotics, artificial life, microbiology and bio-energy harvesting for the purpose of enhancing our understanding of living technologies and how to best design and exploit groundbreaking bio-hybrid systems.",Technological Evolution of Synergy Between Physicochemical and Living Systems,FP7,31 January 2018,01 February 2014,2555978.0 EXCELL,Technical University of Denmark * Danmarks Tekniske Universitet,health,"EXCELL is a novel innovative approach to explore interaction mechanisms between biological materials and systems/nanostructures. It involves a forward-looking cross-disciplinary and design-based research to generate an integrated, biologically inspired technological platform of high complexity, able to monitor cell dynamics at nano-scale. Expertise in cellular and molecular biology, nanosciences, material engineering, biophysics, biotechnology, modelling, and analytical chemistry, are combined to address the targeted goals, which go beyond the state of the art methods used in traditional biotechnology and systems biology. EXCELL will provide a complete Lab-in-a-Cell (LIC) sensor and actuator platform, which is capable of: (1) studying single cells in their natural environment surrounded by other cells or a complex mixture of different cells/tissue, (2) following the dynamics and interdependence of single cell processes from gene, protein, metabolite to compound secretion, exocytosis and cell-to-cell communication, (3) testing how and where various stimuli affect the different levels of the molecular machinery and finally (4) programming cells to be able to differentiate into a particular phenotype. A major task is the design of suitable biocompatible nano/bio interfaces that ensures a sustainable cellular environment. EXCELL provides a unique opportunity for developing advanced, novel experimental tools to address fundamental problems of stem cell research and poses a potential for possible diversification and modulation of developmental programs of stem cells to differentiate them into specific phenotypes. EXCELL has the capacity to drive new discoveries having a significant impact not only in the field of stem cell research and clinical use, but also on molecular engineering, nanosciences, sensor development, diagnostics, therapeutics, biotechnology and industry (smart materials, medical diagnostics, pharmaceutical companies, start-ups)",Exploring Cellular Dynamics at Nanoscale,FP7,31 December 2011,01 September 2008,3780750.0 EXCIPOL,University of Sheffield,photonics,"This proposal combines novel experimentation and physical insight with state-of-the-art advances in technology to establish the field of exciton-polariton physics in major new directions. The new physics takes advantage of unique polariton properties including very light mass, strong non-linearities, bosonic character and direct access to density, phase and quantum statistics. The major goals are: 1. Transform the field into the regime of non-classical polariton physics. Major steps forward will include the polariton blockade where one polariton prevents the passage of the next, and very fast 10-100 GHz single photon sources, opening the way to realisation of a variety of strongly correlated photon phenomena in a solid state system. 2. Achieve a quantum phase transition in a system with strong inter-particle interactions, with particular opportunities deriving from the non-equilibrium nature of the polariton system. 3. In the many particle regime, create non-dispersing polariton wave-packets, study collisions and create the first polariton circuits, capitalising on advantageous soliton and condensate properties. As well as the polariton area, the project will impact on several broader fields: semiconductor physics in revealing new interaction phenomena on the nanoscale, quantum optics and information science in the realisation of very fast single photon sources and quantum circuit functions, and new high density collective phase physics towards exploitation as opto-electronic logic gates and circuits. Advances in technology will be crucial to enable the new directions. They will include fabrication of highly uniform cavities using innovation in crystal growth, the pioneering of a new type of polariton system, waveguide polaritons, and the use of open cavities to permit the application of very short wavelength periodic potentials. These technology goals are challenging but achievable, and have potential to enable major advances over the next 5 to 10 years.",Exciton-Polaritons: New Physics and Long Term Applications,FP7,31 January 2018,01 February 2013,2100000.0 EXCITONIC SOLAR CELL,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"Photovoltaic cells (PVCs) use semiconductors to convert light energy into electrical current and are regarded as one of the key technologies towards a sustainable energy supply. The current PVCs supplying power conversion efficiencies of 10–20%. However, their poor absorbing properties and the difficulty in producing uniform thin films over large area substrates make the manufacturing processes quite costly. Further, most current PVCs harvest solar energy with a wavelength below 1.1 micron, though almost 50% of the sun power reaching the earth is in the infrared (IR) regime, and the power conversion efficiency could be improved with the use of the IR portion above 1.1 micron. This paper proposes the development of radically new nanostructures and molecular materials for the production of innovative solar cells, called excitonic solar cells (XSCs), competitive with traditional energy sources. The goals of the research are to develop XSCs using of semiconductor quantum dots (QDs) as light harvesting units, with a fine tuning of the optical cross section and of the band gap in the IR regime. To design molecular relays (MRs) that connect the QDs to electron conductor materials, the MRs should enable carriers' transport and good adhesion to the electron-transport nanostructures. Moreover, a specifically designed n-type semiconductors will be developed, such as ZnO or TiO2 nanofibers, with architecture, morphology and surface structure suitable to maximise the efficiency of the charge transfer processes at the QD. The competitive cost-efficiency ratios of the materials used in this research will be improved, developing efficient synthesis approaches and surface functionalization to enable reliable, large scale applications of XSC devices. The significance of this research is the integration of innovative materials in XSC devices to be used as environmentally clean, renewable electric power sources, paving the way for short-, medium-, and long-term applications.",Photovoltaic Excitonic Solar Cells,FP7,31 May 2012,01 June 2010,182970.0 EXOMET,European Space Agency * Agence Spatiale Européenne,health,"The ExoMet proposal revolves around innovative liquid metal engineering and the application of external physical fields, in order to significantly influence the microstructures and properties of light alloys, such as aluminium and magnesium. Three types of external fields will be explored, namely: electromagnetic, ultrasonic and intensive mechanical shearing. To meet the future EU challenges of lightweighting and pollution reduction, especially relevant in transportation, it is necessary to improve the castability of light alloys, to enhance grain and eutectic refinement in monolithic alloys, and to develop new high-strength nanocomposites using nano-reinforcers which have only recently become available. Significant mechanical property improvements are foreseen in ExoMet - including 50% increases in tensile strength and ductility, as well as creep resistance up to 300-350 degC (currently limited to about 200 degC in Al and Mg alloys). This applies to both shape castings and wrought products like extruded profiles, bar, cable, sheet and plate. Manufacturing scale-up will be tackled in ExoMet, using a variety of techniques such as low and high-pressure die casting, sand casting, investment casting, differential-presssure casting, twin-roll casting, ultrasound-assisted casting and twin-shear casting. The application of external fields to these industrial techniques is novel and would bring about major savings in energy, scrap and processing cost. Having developed the field-enabled processes and produced high-quality light alloys and nanocomposites, the next stage of ExoMet will be prototypying and the assessment of industrial applications in four selected commercial sectors: (i) automotive powertrain and chassis, (ii) aircraft and aero-engine structures, (iii) space satellite and rockets, and (iv) high-strength high-conductivity Al electrical cabling. Computer modelling, rig-testing, standardisation, life-cycle analysis and patenting will also be undertaken.",Physical processing of molten light alloys under the influence of external fields,FP7,31 July 2016,01 June 2012,9476000.0 EXOTICPHASES4QIT,Wroclaw University of Science and Technology * Politechnika Wrocławska,information and communications technology,"Project covers theoretical/computational studies of exotic phases of quantum matter (especially with fractional and non-Abelian quantum statistics) in graphene and other modern nanomaterials. It is aimed at both fundamental effects and application in future graphene nanotechnology (especially in quantum information technology, via the concept of topological quantum computation). Major goals are: (i) implementing powerful computational methods acquired during the preceding IEF (large scale configuration interaction, quantum Monte Carlo, density functional theory) for application in modelling electronic structure and many-body effects in nanostructures; (ii) understanding new many-body effects in low-dimensional systems (especially those related to emergence of exotic electronic phases), applicable in quantum information technology; (iii) building a research group focused on nanoscience/nanotechnology, benefitting from collaboration with University of Cambridge established during the IEF.",Exotic quantum phases in graphene and other modern nanomaterials - physical foundation for quantum information technology,FP7,08 July 2017,09 January 2011,0.0 EXPRESS,IMEP-LAHC Laboratory,photonics,"The revolutionary potential of nanoscience lies in the ability of designing new materials and functionalities for specific applications taking advantages of quantum nature of electrons. After the breakthrough discovery of graphene, the recent years have witnessed an explosive interest in two-dimensional Transition Metal Dichalcogenides nanosheets - diselenides and disulfides of transition metals, like MoS2, WS2, TiS2 and WSe2 - due their high technological potential for renewable energies, nanoelectronics and nanocatalysis. Major advances in this field heavily depend on the understanding of the electronic excitations sustained by these nanostructures under irradiation (by light, electron beams, synchrotrons or ultra-fast lasers) and on the ability to link the local chemical, electronic and structural modifications to changes in their macroscopic optical behavior. This project aims to provide a deep insight (through theory, simulation and experiments) to the electronic and optical properties of semiconducting Transition Metal Dichalcogenides nanosheets. By applying innovative computational modelling ab-initio techniques - within the framework of Time Dependent Density Functional Theory - the electronic structure and optical response of such systems will be investigated from the atomic scale up and then compared to experiments (i.e. electron energy loss spectroscopies). One key objective will focus on quantum confinement effects, evaluating the change in the electronic spectra when the size of the system is reduced. A second and fundamental aim is to investigate chemical modifications, e.g. the insertion of dopant atoms or molecules into the layered structure of the material. Due its high fundamental scientific content, enormous technological potential and strong multidisciplinary character, the present proposal will provide a significant step towards the understanding of optoelectronic properties of nanostructures through theory, simulation and material designing.",Understanding and EXPloiting dielectric REsponse in novel Semiconducting nanoSheets,FP7,28 February 2015,01 March 2013,194046.0 EXQUISITE,Technical University of Berlin * Technische Universität Berlin,health,"In this project, we will control photonic nanostructures by external feedback, optical injection and synchronization. This will allow us to study nonlinear dynamics in quantum systems and to externally manipulate and stabilize light-matter interaction in the regime of quantum electrodynamics (cQED). We will experimentally and theoretically address a) optical injection and feedback control of quantum dot (QD)–microlasers, b) quantum control cQED systems via delayed single photon feedback, and c) mutually coupled and synchronized chaotic microcavity systems. In a) we will advance the concepts of time-delayed coupling in standard semiconductor laser diodes to few photon states, where quantum fluctuations contribute to or even dominate over the usual classical dynamics. Feedback-coupling in microlasers will allow us to explore the limits of a classical description of chaotic laser dynamics via the Lang-Kobayashi rate equations and to develop an advanced model taking cQED- and QD-specific effects into account. This subject will be complemented by the study of optical injection of coherent light and non-classical light into microlasers to influence and study mode-locking, chaos and stimulated emission down to the quantum level. Single photon feedback in b) will be applied to stabilize coherent coupling of light and matter and to act against decoherence which constitutes a major bottleneck for application of semiconductor nanostructures in quantum information technology. In c) the mutual coupling of microlasers will be used to study synchronization of chaotic quantum devices at the single photon limit and to explore the underlying physics of isochronal synchronization. Our work will have important impact at an interdisciplinary level on the development of nonlinear dynamical systems towards the quantum limit and the understanding of fundamental light-matter interaction in the presence of time delayed single photon feedback.",External Quantum Control of Photonic Semiconductor Nanostructures,FP7,31 March 2019,01 April 2014,1999800.0 EXT-HOSSAM HAICK,Technion Israel Institute of Technology,health,"The focus of this proposal is to develop and study inexpensive, disposable artificial olfactory systems (so called “electronic nosesâ€) for the detection of various odors in general and lung cancer biomarkers in patients’ breathe in particular. Specifically, we propose to:(a) develop and study arrays of chemiresistors based monolayer-protected nanoparticles, chemicapacitors based molecularly modified carbon nanotubes, chemiresistors and/or chemically sensitive field effect transistors of nonoxidized, molecule-terminated silicon nanowires, and chemiresistors based columnar discotic liquid crystals; (b) develop an improved fundamental understanding of the signal transduction mechanism of the various classes of sensors; and (c) investigate the use of the developed breath vapor sensors in a selected clinical application, particularly targeting the early diagnosis, detection, and screening of lung cancer. Furthermore, we propose to investigate whether one can differentiate between patients with different stages of lung cancer, and thus evaluate whether we can provide a robust, early warning system for lung cancer. Achieving the goals of this proposal will improve the scientific basis for obtaining enhanced performance from artificial olfactory systems in general. It will, therefore, enabling potential detection of the other health/disease states. Furthermore, we expect to be able to achieve sensors with enhanced sensitivity, compared to equivalent ones, a fact that will allow us to progress further in the clinical examinations as well as to evaluate whether we can identify patients, which have early stages of the disease. Success in this endeavor would additionally provide a launching pad for initiatives in areas of diagnostic breath testing, currently unexplored by electronic nose systems.",DEVELOPING AND STUDYING ARTIFICIAL OLFACTORY SYSTEMS BASED ON NANOCOMPOSITE MATERIALS FOR DETECTING CANCER VIA BREATH SAMPLES,FP6,31 March 2011,01 April 2007,1725370.2 EXTENDFRET,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Förster fluorescence resonance energy transfer (FRET) is one of the most popular methods to measure distance, structure, association, and dynamics at the single molecule level. However, major challenges are limiting FRET in several fields of physical and analytical sciences: (i) a short distance range below 8 nm, (ii) a concentration range in the nanomolar regime, and (iii) generally weak detected signals. At the interface between physical chemistry and nano-optics, the proposal objective is to extend the effectiveness of single molecule FRET using plasmonic nanocircuits to: (i) perform FRET on a range up to 20 nm, (ii) detect a single FRET pair in a solution of micromolar concentration, and (iii) improve the statistical distribution in FRET measurements. To meet its ambitious goals, the proposal introduces plasmonic nanocircuits to tailor the light-molecule interaction at the nanoscale. Energy transfer between donor and acceptor fluorophores is efficiently mediated through intense surface plasmon modes to extend the FRET distance range and improve the fluorescence signal. Moreover, the nanocircuits will be combined with recent innovations in biophotonics: stimulated emission of acceptor fluorescence, full dynamic analysis, and fluidic nanochannels. The scientific breakthroughs and project impacts will open new horizons for proteomics, enzymology, genomics and photonics. For elucidating molecular structure, the long range FRET will enable understanding the folding structure of large DNA or protein molecules. For assessing chemical reactions, achieving single molecule analysis at micromolar concentration is essential to monitor relevant kinetics, reveal sample heterogeneity, and detect rare and/or transient species. For analytical chemistry, nanocircuits are ideal for sensitive biosensing on a chip. For photonics, nanocircuits can realize key components for optical information processing at the nanoscale.",Extended fluorescence resonance energy transfer with plasmonic nanocircuits,FP7,31 December 2016,01 January 2012,1477942.0 F-LIGHT,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"The Project F-LIGHT aims at exploiting in innovative way the Förster resonant energy transfer (FRET) process in excitonic solar cells, by adding proper donor/acceptor (D/A) couples, which lead to broadening of the absorption spectral range and improve the photoconversion efficiency. The D/A couples are composed of commercially available dye molecules and colloidal and non-colloidal quantum dots (QDs). The investigation takes advantage of the outstanding injection properties of commercially available dye molecules and naked QDs generated by successive ionic layer absorption and reaction (SILAR), while benefiting of the outstanding stability and high electric insulation of suitably passivated colloidal QDs. The first ones act as donors strongly attached to the photoanode, the second one acts as acceptor systems to expand the absorption band. One further fundamental idea is the chemical bonding inside the D/A pair, to enhance FRET probability and optimize surface occupancy by the acceptors. Key point of the Project will be the in depth investigation of the structure, electrical and optical properties of the nanostructured heterointerfaces between the D/A couples and the photoanode by applying advanced techniques (SPM, STS, PEEM, TRPL) all available at the outgoing host Institution. Expected results can give concrete contribution to overcome the intrinsic limits of the state of the art excitonic cells, allowing exploitation of all their potential, whose efficiency is not limited by the Queisser limit and could be as high as 45%. The applicant will be trained on techniques not currently in his background (SPM, STS, TRPL), and whose application represents significant step forward the comprehension of the physico-chemical mechanisms of FRET in excitonic solar cells. Strong synergistic activities are planned between the incoming and outgoing hosts, aiming at setting up durable scientific collaboration as one of the main outcome of the Project, after the reintegration phase.",Förster resonant energy transfer for high efficiency quantum dot solar cells,FP7,31 August 2015,01 September 2012,200978.0 FAB-HETERO-COATS,Consejo Superior De Investigaciones Científicas (CSIC),health,"'As the average age of us ''European nationals'' increases, the demand for major joint replacements is expected to rise in accordance. Although implants are considered an excellent solution to many health problems, any time a medical device is implanted into one's body there is a high risk for infection not only in the short but in the medium term as well. Additionally, the long term wear behavior of the surfaces in contact significantly affects the life of implants. In this manner, there is a need for new multifunctional coatings. In comparison with other implant materials, tetrahedral amorphous carbon (ta-C) have excellent blood and tissue biocompatibilities and therefore many artificial joints and cardiovascular implants are being coated today with ta-C materials. Recent studies have shown the possibility of incorporating certain toxic elements (e.g. Cu, Ag, or V) into hard carbon coatings with the idea of providing the implants with necessary infection resistance. However, until now, these coatings could only be deposited either by hybrid pulsed laser deposition (PLD) techniques or by multi-step processes, making their manufacturing expensive and unrealistic.We propose to investigate the development, the mechanical properties and wear behavior of heterophase ta-C:Me nanocomposite coatings deposited from two pulsed cathodic arc (PCA) plasma sources. One of the advantages of this novel deposition method over hybrid PLD techniques is its potential application to large surface areas and a comparatively less expensive technology while producing an intense highly ionized plasma plume which is necessary for the deposition of the hard ta-C phase. After the deposition, glow discharge optical emission spectroscopy (GDOES) will be used to obtain a quick analysis of the homogeneity of the metallic phase vs. depth allowing us to adjust the process parameters and improve the manufacture and design of novel ta-C:Me coatings.'",Fabrication of Novel Heterophase ta-C:Me Nanocomposite Coatings for Biomedical Applications,FP6,30 November 2008,01 February 2006,266238.79 FACIT,IBM Research GmbH,information and communications technology,"The CMOS industry relies on the capabilities of engineers to control atomic positions at sub-nm scale across several interfaces. The formation of abrupt interfaces is heavily dependent on the thermal budget during their formation and of any other subsequent thermal treatments during device fabrication. As device dimensions decrease, the thicknesses of all junctions and interfaces must be reduced so that they do not become the major fractional volume of the whole device. In that framework, ultra fast annealing is becoming a key technology to enable the fabrication of nano scaled devices.",Fast Anneal of Compound semiconductors for Integration of new Technologies,FP7,,,0.0 FACOMP,Fundación Tecnalia Research & Innovation,construction,"Curtain wall facade is being constituted in one of the most used at the present time due to its facility of construction, lightness and to the great variety of materials and finished textures that are possible to obtain. The curtain walls are constituted by two elements clearly differentiated: • The structural profiles of the curtain wall (the one in charge to support the glass or the coating panels and to join structurally the facade to the building) • And the coating material which is the one that provides the final finished one. Generally this finishing is glass although exists the possibility of using other materials if it’s required to give an opaque finish to the end item. At the present time the materials more used for the structural profiles are aluminium and steel. These materials have a widely extended use although they often present/display problems of supply and recycling. Besides, it’s thermal behaviour is not appropriate since they are materials of great thermal transmission. This project is intended to define a new system and a new nanomaterial to be used in substitution of the steel and aluminium for structural profiles. The system to develop must fulfil the same or better mechanical characteristics than the steel and aluminium, must be lighter, weather resistant and with better thermal and acoustic behaviour. The introduction of a new material will also imply a redesign or an adaptation of characteristics of the rest of materials that compose the curtain wall (joints, silicone adherence, glass, etc). The materials that will be used for the profiles are polymeric nanocomposites reinforced with fibres and nanoparticles. These materials exhibit several advantages comparing with those of the aluminium and steel: Mechanical properties: Lightness, Maintenance, Chemical behaviour, thermal properties, Design flexibility and Fire properties.",Polymeric nanocomposite profiles for curtain walls,FP7,08 July 2013,10 January 2008,954304.4 FAEMCAR,University of Namur * Université de Namur,health,"Owing to very small dimensions of nanostructures in one or more directions, spatial confinement of charge carriers is fully achieved, providing thereby a discrete spectrum of their energy states. In addition, intrinsic spatial inhomogeneity of nanostructures dictates nanoscale inhomogeneity of the surrounding electromagnetic fields. Therefore, understanding the properties of nanostructures requires to deal with the intricate characters of their atomic structure, electronic structure and electromagnetic environment. Coming within the scope of this new field of 'nano-electromagnetics', the present project aims at understanding how and why carbon nanostructures might have interesting electromagnetic properties. The core of the project is the development, the experimental validation and the exploitation of a consistent theory of the electromagnetic response in radio, microwave and THz frequency ranges of regular carbon nano structures and polymer composites based on nanocarbons. In particular, the project intends to: - to provide a forum for scientists specialized in different areas of the nanocarbon, and nanocarbon materials synthesis and applications; - interpret experimental electromagnetic data collected; - define physical grounds and perform experiments for the design of a new generation of ultra-light materials with controlled electromagnetic properties; - explore the possibility of using chemically-modified nanocarbons in 'thin' bio-medical and nanophotonics applications. At this aim, seven teams belonging to three different scientific areas will joint efforts. The partners will equally contribute to the achievements of the objective of this multi-disciplinary project by bringing their expertise in condensed-matter physics, electromagnetic theory, and applied electromagnetism. The research efforts, both theoretical and experimental, are articulated around four work packages all involving strong collaborative links and knowledge transfer across the consortium.",Fundamental and Applied Electromagnetics of Nano-Carbons,FP7,31 October 2016,01 November 2012,142500.0 FAMOS,Medical University of Vienna * Medizinischen Universität Wien,health,"Biophotonics offers low-cost, non-invasive, accurate, rapid alternatives to conventional diagnostic methods and has the potential to address medical needs with early detection and to reduce the cost of healthcare. FAMOS will develop a new generation of light sources with step-changes in performance beyond the state-of-the-art to radically transform biophotonic technologies for point-of-care diagnosis and functional imaging. This will enable optical diagnostics with superior sensi-tivity, specificity, reliability and clinical utility at reduced cost, heralding an imaging renaissance in Europe. FAMOS addresses optical imaging from molecular over (sub)cellular to individual organs, with no gap in the arsenal of diagnostic tools for medical end-users. The world-class multidisciplinary FA-MOS team of 7 leading academic institutions and 10 top SMEs has unique complementary knowledge of optical coherence tomography, adaptive optics, photoacoustic tomography, coherent anti-stokes Raman scattering, multiphoton tomography as well as swept-source, diode-pumped ultrafast and tuneable nanosecond pulse lasers. Combinations of some techniques will offer multi-modal solutions to diagnostic needs that will exploit and enhance the benefits of each modality. FAMOS technologies have wide applicability, but our specific focus is on diagnosis in ophthalmol-ogy and oncology. Partnerships with leading innovative clinical users will enable preclinical evalua-tion. The objectives of FAMOS are: • Develop new light sources with a step-change in performance (2-3 times more compact and up to 3-4 times cheaper diode pumped Ti:sapphire, 4-10 times faster swept sources and tuneable nanosecond pulse sources) • Integrate these with optical imaging for a step-change in diagnosis (2-5 times better resolution cellular retinal imaging with more than 10 times larger field of view, up to 10 times enhanced penetration single source subcellular morphologic imaging, increased selectivity of intrinsic mo-lecular sensing as well as several frames per second deep tissue functional tomography • Perform preclinical studies to demonstrate novel or improved ophthalmic and skin cancer diag-nosis establishing novel biomarkers (melanocyte shape, NADPH, melanin concentration, Hb/HbO2 as well as lipid, water and DNA/RNA concentration) • Enable exceptional commercial opportunities for SMEs • Provide state-of-the-art academic training",Functional anatomical molecular optical screening,FP7,30 September 2016,01 October 2012,1.0099999E7 FANCEE,University of Eastern Finland * Itä-Suomen Yliopisto,information and communications technology,"Development of efficient electron sources is crucial for a wide range of applications including integrated vacuum microelectronics, MEMS, bright flat panel displays, energy conversion devices, and compact microwave amplifiers. In the search for new cathodes capable to produce a strong electron flux at low energy consumption, carbon materials possessing extraordinary field emission properties have been attracted a lot of attention. Control of the morphology and electron properties of nanocarbon species opens tremendous opportunities in the development of advanced electron sources..",Fundamentals and Applications of Nano-Carbon Electron Emitters,FP7,03 July 2018,04 January 2012,0.0 FAST TRACK,Juelich Research Centre * Forschungszentrum Jülich,energy,"In recent years, the effort in thin-film silicon (TFSi) was made at solving industrialization issues. In 2010, several companies demonstrated 10% stable modules (> 1 m²). The major 'bricks' for efficient production are now in place. Next challenges are linked to the fact that TFSi multi-junction devices, allowing for higher efficiency, are complex devices, in which the substrate geometry and each layer have an impact on the full device. This explains why the first industrializations focused on 'single technology' roads (e.g., Jülich-AMAT or EPFL-Oerlikon approaches). This project focuses at bringing the next-generation technology to the market, using newly developed state-of-the art knowledge to solve the complex puzzle of achieving at the same time strong light in-coupling (high current) and good electrical properties (open-circuit voltage and fill factor). In a unique collaborative effort of the leading EU industries and research institutions in the field, the consortium will go beyond the current technology status by • Introducing novel materials, including multi-phase nanomaterials (such as doped nc-SiOx, high crystallinity nc-Si materials), stable top cell materials, nanoimprinted substrates and novel or adapted transparent conductive oxides; • Designing and implementing ideal device structures, taking into account the full interaction of layers in multi-junction devices; • Controlling the growth of active layers on textured materials; • Working at processes that could allow a further extension of the technology such as very high rate nc-Si deposition or multi-step superstrate etching; • Transferring processes, including static and dynamic plasma deposition, from the laboratory to pilot scale, with first trials in production lines. The targets of the project is to achieve solar cells with 14% stable efficiency, leading to the demonstration of reliable production size prototypes module at 12% level. Potential cost below 0.5€/Wp should be demonstrated.",Accelerated development and prototyping of nano-technology-based high-efficiency thin-film silicon solar modules,FP7,28 February 2015,01 March 2012,9300000.0 FAST-DOT,University of Dundee,health,"FAST-DOT aims to implement a new range of ultrafast quantum-dot lasers for critical bio-medical applications. This project will develop portable, low-cost, reliable, highly efficient ultrashort pulse and ultra-broadband tuneable laser sources. The key technical innovation -quantum dots (QDs) - are based on novel semiconductor nanostructure clusters which demonstrate remarkable new photonic properties. QD structures will afford major advances in ultrafast science and technology by exploiting the unique combination of QD properties (high optical quality, efficient light generation, ultrafast carrier dynamics and broadband gain bandwidth) at wavelength range which not easily accessible with current technologies. The FAST-DOT consortium brings together a unique and compelling group of world-leaders in the physics of QDs and QD photonic devices, system integrators and biophotonic. This research will realise a full understanding of the underlying ultrafast properties and physics of QD structures and exploit these effects in the construction of novel highly compact, reliable and environmentally-stable sources of ultra-short pulses. The new QD sources will be investigated and validated in a range of bio-photonic applications including OCT; Non-linear Microscopy; Nanosurgery and minimally invasive diagnostics. The availability of compact and inexpensive ultrashort pulse lasers will have widespread impact in uptake by making many applications more affordable and opening up new application areas. The project unites 18 complementary European research groups and companies with international reputations in the development of semiconductor materials and their use in efficient ultra-fast lasers, related applications and marketing. All of the groups have record of collaboration and a strong record in producing high quality results and joint publications. This programme will contribute to further extending Europe's world-leading position of in photonics and ultrafast technology.",COMPACT ULTRAFAST LASER SOURCES BASED ON NOVEL QUANTUM DOT STRUCTURES,FP7,31 August 2012,01 June 2008,1.01E7 FASTCARD,Stiftelsen for Industriell og Teknisk Forskning (SINTEF),energy,"To meet short term European 20-20-20 objectives and long term targets of European Energy Roadmap 2050, an energy paradigm shift is needed for which biomass conversion into advanced biofuels is essential. This new deal has challenges in catalyst development which so far hinders implementation at industrial level: Firstly, biomass is much more complex and reactive than conventional feedstock; secondly development of such catalysts is traditionally done by lengthy empirical approaches. FASTCARD aims at: -Developing a novel 'rational design' of nano-catalysts for better control; optimised based on advanced characterisation methods and systematic capture of knowledge by scalable mathematical and physical models, allowing prediction of performance in the context of bio-feedstocks; -Developing industrially relevant, insightful Downscaling methodologies to allow evaluation of the impact of diverse and variable bio-feedstocks on catalyst performance; -Addressing major challenges impacting on the efficiency and implementation of 4 key catalytic steps in biobased processes: • Hydrotreating (HT) and co-Fluid Catalytic Cracking forming the pyrolysis liquid value chain for near term implementation in existing refining units as a timely achievement of the 20-20-20 objectives: addressing challenges of selectivity and stability in HT; increased bio-oil content in co-FCC. • Hydrocarbon (HC) reforming and CO2 tolerant Fischer Tropsch (FT) forming the gasification value chain for longer term implementation in new European relevant infrastructure, representing 100% green sustainable route for Energy Roadmap 2050: addressing challenges of stability and resistance in HC reforming; stability and selectivity for FT. Advances in rational design of nano-catalysts will establish a fundamental platform that can be applied to other energy applications. The project will thus speed-up industrialisation of safer, greener, atom efficient, and stable catalysts, while improving the process efficiency.",FAST industrialisation by CAtalysts Research and Development,FP7,31 December 2017,01 January 2014,8234108.0 FASTER,University of Birmingham,transport,"Despite intensive abatement efforts, airborne particulate matter remains a major public health issue with costs across the European Union estimated at 600 billion euros in 2005. Road traffic remains one of the major sources of particulate matter, and diesel emissions are by far the largest source of atmospheric nanoparticles in urban areas. Semi-volatile organic compounds emitted largely in the condensed matter phase are a major component of diesel emissions, and as primary particles are advected from their road traffic source, the semi-volatile compounds vaporise and are oxidised, forming a greater mass of secondary organic aerosol (SOA). However, the semi-volatile compounds are extremely poorly characterised as they are not resolved by traditional gas chromatographic methods, presenting an unresolved complex mixture (UCM). For this reason, despite being a major precursor of SOA, such compounds are often poorly represented or completely omitted from atmospheric chemistry-transport models. This proposal is concerned with applying new two dimensional gas chromatographic methods to characterisation of the UCM at a molecular level which will be followed by studies of the physico-chemical properties of representative components of the semi-volatile emissions. The very abundant nucleation nanoparticle mode of diesel emissions is comprised almost entirely of semi-volatile organic material and hence these particles are progressively lost from the atmosphere by evaporation. Until now, there has been insufficient knowledge of the properties of the semi-volatile components to model this behaviour reliably. Such processes will be quantified through both controlled laboratory studies and carefully designed field measurements. Numerical models on both a street canyon and a neighbourhood (5x5 km) scale will be developed to simulate the key processes, such that spatial patterns and size distributions will be predicted, and compared with independent measurements.","Fundamental Studies of the Sources, Properties and Environmental Behaviour of Exhaust Nanoparticles from Road Vehicles",FP7,03 July 2020,04 January 2013,2394959.0 FAWORIT2011,Bay Zoltán Applied Research Public Nonprofit Ltd. * Bay Zoltán Alkalmazott Kutatási Közhasznú Nonprofit Kft.,transport,"o \"CONCEPT\"",A Day of the Researcher under the Magnifying Glass - in and out of Laboratory,FP7,11 June 2013,05 January 2011,0.0 FCANODE,Technical University of Denmark * Danmarks Tekniske Universitet,energy,"For PEM Fuel Cells to attain economic viability for mass production, catalyst cost must be reduced. Currently, platinum-based supported nanoparticle catalysts, are used for the hydrogen oxidation reaction at the anode. The replacement of such catalysts by cheaper non-noble alternatives is proposed. Currently, noble metal based systems alone exhibit both the stability required in the strongly acidic humidified environment of the fuel cell, and the sufficiently large current densities required. Hence, the challenge is to find binary, ternary or even quaternary non-noble systems, which have the necessarily high rates of hydrogen oxidation and which are stable in the environment of the fuel cell. In addition, new developments in membrane technology highlight the need to explore the performance of catalysts in a higher temperature regime (in the region of 130-200°C). To accomplish these aims the following novel route will be used involving a multidisciplinary approach from theoretical design through to the final operating membrane electrode assembly. Initially, Density Functional Theory studies will be used to calculate critical bond energies and activation barriers of processes relevant to the fuel cell electrodes and produce trends in reactivities for metal alloy species and intermetallic compounds. The next step will be the fast screening of catalysts for these descriptors using combinatorial methods. These two preliminary steps will determine the most promising systems and compositions to take forward into the subsequent stages. The selected catalysts will then be produced as carbon-supported nanoparticles and subsequently investigated with regards to their performance for the hydrogen oxidation reaction, their stability to acidic media and tolerance to CO and CO2. Finally, the behaviour and stability of selected catalysts will be assessed within the single cell environment and their potential for large-scale production investigated.",Non-noble Catalysts for Proton Exchange Membrane Fuel Cell Anodes.,FP6,31 January 2010,01 February 2007,1492866.0 FDBNSDNA,Universiteit Utrecht * Utrecht University,health,"Since the physicist Richard Feynman famously remarked that '[t]here is Plenty of Room at the Bottom' half a century ago, rapid advances in science have shown us that these words do not only apply to the realm of physics, but equally well to all other the disciplines that make up the exciting fields of biophysics and life sciences. However, the chemistry, biology, and physics we find at this 'bottom', at the level of individual molecules and molecular aggregates, are succinctly different from what one encounters on the macroscopic scale: thermal motion becomes important, while inertia plays a very minor role; and the statistics of large numbers encountered in the test tube have to be replaced with analysis of discrete interaction between a few partner molecules. From this follows that all structures build from nanometre sized (molecular) units and all their interactions are highly dynamic and susceptible to disturbances by exceedingly small forces in the low pico-newton (10^-12 N) range. The aim of this career integration proposal is to expand my previous work on the effects of small mechanical forces in the interaction of DNA with regulatory proteins, and extend it to establish the dynamic mechanical parameters of novel non-standard, self-assembled DNA structures based on the self-recognition of the DNA base guanine, which show potential as building blocks for future molecular-scaled devices and electronics ('G-wires'). Putative poly-guanine structures have been reported to occur ubiquitously in the human genome, where they make up the highly repetitive ends of chromosomes (telomers) and are found throughout regulatory sequences of the genetic code ('G-quadruplexes'); this makes them potential targets for therapeutic drugs in the fight against cancer. Although the chemical environment needed for assembly has been studied, little to nothing is known about their physical properties, especially on the biologically and technologically relevant single molecule level.",Force-Dependent Behaviour of Non-Standard DNA Structures and their Uses in Artificial DNA Machines and in Genetic Regulation,FP7,31 October 2015,01 November 2011,100000.0 FDPA,National Hellenic Research Foundation * Ethniko Idryma Erevnon,photonics,"Over the years the participating NHRF teams have developed and applied several methods: (i) for the calculation of the linear and non-linear optical (LandNLO) properties of molecules, crystalline solids and liquids and (ii) the synthesis of several nano-structured materials. The proposed transfer of knowledge (ToK) involves the understanding, implementation, extension and use of: (i) a linear scaling method, because such approaches provide reliable results for the properties of systems involving hundreds of atoms at a computational costs, which scales linearly with the size of the system, (ii) a recently proposed technique for the calculation of the vibrational contributions to the LandNLO properties of derivatives with high anharmonicities and (iii) a technique for the synthesis of endohedral metallo-fullerenes and a method for their separation and isolation in pure form. The proposed competence connected with our expertise on the calculation of the LandNLO properties of molecules and the synthesis of fullerene-based materials will be used (i) to calculate the LandNLO properties of a selected series of charged - transfer fullerene derivatives, among which we note a series of endohedral metallo-fullerenes and substituted fullerenes (one or more carbon atoms of the cage have been substituted by hetero-atoms) and (ii) to design a set of novel fullerene-based nano-hydrids and endohedral metallo-fullerenes, with optimum properties for photonic applications. The more suitable (in terms of their NLO properties) of the designed compounds will be synthesized and characterized by the team of one of the participating partners, while their NLO properties will be measured by the group of another partner, employing the optical Kerr effect. By combining design/modeling, synthesis and characterization as well as measurements, we expect to take the full advantage of the proposed ToK and to maximize the added value.","Fullerene Derivatives For Photonic Applications: Design, Synthesis and Measurements",FP6,30 September 2010,01 October 2006,389953.44 FEMOS,University of Strasbourg * Université Louis Pasteur de Strasbourg,information and communications technology,"Metal ions can play unprecedented role in function of mechanically linked molecules such as rotaxanes or catenanes. Due to a metal ion, a molecular system can respond to external stimulus (electrochemical process, variation of pH est.) with movement of the component parts that is essential property of molecular machines. Aims of this project are development of novel three fold symmetrcal [3]-catenane with three mechanically interlocked rings possessing two different coordination sites in each ring and investigation of electrochemical behaviour of the iron-ion complex of this [3]-catenane. The iron-[3]-catenane complex will be synthesized employing template method. It would be the first [3]-catenane prototype of molecular machine with a working iron-centre. Successful implementation of the proposal would represent a landmark achievement for research in chemical topology and provide key information on kinetics of this novel supramolecular system which can be of interest as a potential building block for molecular electronic devices.",Metamorphosis of a symmetrical [3]-catenane,FP6,31 May 2008,01 November 2006,155383.96 FEMTO/NANO,Stichting Katholieke Universiteit * Catholic University Foundation,information and communications technology,"Nanoscale objects like magnetic molecules and clusters, quantum dots, and graphene, bring us novel physical concepts. Recently, the temporal scale of the order of tens of femtoseconds (femtoscale) became available and new physical phenomena associated with this time scale, such as laser-induced electron and magnetic phase transitions, were discovered. The theoretical background for understanding this new physics is still rather poor. This temporal scale, like the spatial nanoscale is intermediate between micro- and macroworld making the standard approaches developed in micro- and macrophysics not suitable anymore. Essentially new theoretical ideas and methods are necessary for its description, especially in a combination with the spatial nanoscale. The aim of this project is to provide such a background via detailed studies of key problems, and open the way for new practical applications.",Nonequilibrium phenomena at femtosecond/nanometer scale,FP7,09 June 2020,10 January 2013,0.0 FEMTONANO,East China University of Science and Technology,photonics,"Lately composite materials containing metal nanoparticules have found an increasing number of applications in different fields of science and technology. In particular glasses containing metallic nanoparticules are of great interest for photonics because of their unique linear and nonlinear optical properties, which are determined by surface plasma oscillations of the metal clusters. The surface plasmon resonance depends strongly on shape, distribution and concentration of the nanoparticules, as well as on the surrounding dielectric matrix. This offers the opportunity to manufacture very promising new nonlinear materials, nanodevices and optical elements by manipulation of the nanostructural properties of the composite medium. Recently, laser-based techniques leading to modifications of shape and size of the metal clusters have increasingly become of great interest and proved to provide a very powerful and flexible tool to control and optimize the linear and nonlinear optical properties of such materials. More generally, this technique allows the engineering of the optical properties of the material via gaining control over the spatial distribution of nanoparticules in the glass matrix. The possibility to 3D spatially structure the linear and non-linear properties of various materials leads thus to consider femtosecond laser as a fantastic tool. However, a deeper understanding of the light-matter interaction, with emphasis on multiphotons processes, is profoundly needed for the development of new optical devices based on nanoparticules mastering. This proposal is thus dedicated to 1/ to understand the processes of the formation of metallic nanostructures in glassy media and 2/ to manipulate, to master the nanocluster shape and mostly distribution within the dielectric matrix. This will allow structuring the non-linear properties in the dielectric matrix on demand.",Femtosecond laser induced nanoclusters in glasses for photonic applications,FP7,28 February 2011,01 March 2010,15000.0 FEMTONANO,University of South Paris * Université Paris-Sud,photonics,"Lately composite materials containing metal nanoparticules have found an increasing number of applications in different fields of science and technology. In particular glasses containing metallic nanoparticules are of great interest for photonics because of their unique linear and nonlinear optical properties, which are determined by surface plasma oscillations of the metal clusters. The surface plasmon resonance depends strongly on shape, distribution and concentration of the nanoparticules, as well as on the surrounding dielectric matrix. This offers the opportunity to manufacture very promising new nonlinear materials, nanodevices and optical elements by manipulation of the nanostructural properties of the composite medium. Recently, laser-based techniques leading to modifications of shape and size of the metal clusters have increasingly become of great interest and proved to provide a very powerful and flexible tool to control and optimize the linear and nonlinear optical properties of such materials. More generally, this technique allows the engineering of the optical properties of the material via gaining control over the spatial distribution of nanoparticules in the glass matrix. The possibility to 3D spatially structure the linear and non-linear properties of various materials leads thus to consider femtosecond laser as a fantastic tool. However, a deeper understanding of the light-matter interaction, with emphasis on multiphotons processes, is profoundly needed for the development of new optical devices based on nanoparticules mastering. This proposal is thus dedicated to 1/ to understand the processes of the formation of metallic nanostructures in glassy media and 2/ to manipulate, to master the nanocluster shape and mostly distribution within the dielectric matrix. This will allow structuring the non-linear properties in the dielectric matrix on demand.",Femtosecond laser induced nanoclusters in glasses for photonic applications,FP7,28 February 2010,01 March 2009,86083.0 FEMTOSPIN,University of York,information and communications technology,"Information storage technology is essentially based on nanostructured magnetic materials. Considerable research effort is aimed at increasing the density of stored information and this generally requires increasingly sophisticated media design to engineer the desired combination of low write field and thermal stability of recording information. An alternative approach is Heat Assisted Magnetic Recording in which a laser is used to heat the medium to a sufficiently high temperature to assure writability using currently available write head fields. Also a new, highly promising, development is that of spin electronics in which the spin of the electron rather than merely the charge forms the basis of the device operation. This holds the prospect of allowing technology to develop beyond the limits of miniaturisation of standard electronics and may yield the solution of the increasing power requirements for conventional electronic devices. However, the switching speeds are limited by precessional motion of the magnetic spins to hundreds of picoseconds. However, magnetic spins can be manipulated on the femtosecond timescale. However, the physics of the processes occurring on this timescale is poorly understood. The proposal aims to develop a multiscale approach to the theoretical understanding of femtosecond magnetisation processes and to make a critical comparison with experimental data. The overall goal of the project is to use this understanding to optimise materials for ultrafast (femtosecond) reversal and to develop computational tools for future materials and device design.",Multiscale Modelling of Femtosecond Spin Dynamics,FP7,05 July 2017,06 January 2012,3999600.0 FENASY,University of Castilla-La Mancha * Universidad de Castilla-La Mancha,health,"In this project (FENASY), we wish to study fast (picosecond regime, ps) and ultrafast (femtosecond regime, fs) dynamics of some (guests) porphyrins derivatives in solutions and confined in chemical and biological nanocavities and nanochannels provided by cyclodextrins, Human Serum Albumin protein, and MCM-41 zeolite. The guests and hosts are being used in different fields of Science and Technology. We will interrogate their photoreaction and relaxation dynamics and study the effect of nanoconfinement on the related and subsequent elementary events at both ps and fs time scales. Powerful techniques based on ultrafast laser and single molecule technologies will be our tools to carry out FENASY. We will then focus on studying the relationship between the photodynamics (time domain) and nature and size of the formed nanostructure (space domain, nano to micrometer domain). The expected results will allow explaining the relaxation behaviour of these important molecules upon excitation to Soret and Q- bands, and the relationship to their photochemistry in solution and for the first time within chemical and biological nanocavities and nanochannels. We believe that the expected results will be of great interest to the scientific community in designing new derivatives of these and other systems for use in nanotechnology (nanoLED's, nanostwitches, etc), nanodrugs (nanophotodynamics therapy of cancer), and environmental science (heavy metal nanocleaning). Key words. Femtochemistry, single molecule fluorescence microscopy, porphyrins, nanocavity, cyclodextrins, protein, zeolites, dynamics, emission, absorption, nanotechnology, biotechnology, environmental science, photodynamic therapy.",Space and Time Resolved Ultrafast Dynamics of Few Porphyrins Derivatives in Nanosystems,FP7,01 December 2009,02 June 2008,120934.0 FETAL-MED,Clinic Foundation for Biomedical Research * Fundació Clínic per a la Recerca Biomèdica,information and communications technology,"Fetal Medicine research involves a multidisciplinary approach and affects yearly >5 million pregnancies in Europe. An international multidisciplinary training programme around fetal medicine is proposed, a virtual European Fetal Medicine Institute formed by three leading European Fetal Medicine Research Centers from Barcelona, Leuven and London. All are leaders in clinical and basic multidisciplinary research in the field. Each partner has a core multidisciplinary 'Research Group in Fetal Medicine' supplemented by associated groups to offer training in complementary skills or technology, including Pathology, Genetics, Molecular Biology, Epidemiology, Radiology, Cardiology and Neonatology. The 'Euro-Fet-Med' Institute offers a unique opportunity for researchers from a variety of fields. Main objectives are (1) to provide high level research training in any of the specific fields involved in fetal medicine research; (2) to provide fellows a multi-faceted research training in all complementary aspects essential for their adequate formation. A modular training programme is offered for 9 short stays (12 months) and 6 PhD (3 year), structured in two modules: (1) a truncus communis (background) education module with courses and specific actions in a variety of fields (fetal physiology and diseases, epidemiology and biostatistics, ethics, pathology, psychological approach, etc), and (2) a specific research training project in the ongoing research areas within the consortium. The programme will contribute to the objectives of the Marie Curie actions by offering early stage researchers high level specific and background training.",A MULTIDISCIPLINARY RESEARCH TRAINING PROGRAMME IN FETAL MEDICINE AND HEALTH,FP6,31 December 2009,01 January 2006,1589144.65 FFLOWCCS,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),energy,"In many natural and industrial situations, fluids in cavities, membranes or pipes of complex shape grow as well as modify the structures through which they flow. This leads to important challenges both fundamental, like biological morphogenesis, and practical, like the motion of nano-electromechanical systems (NEMS). We seek to substantially advance the understanding of the resulting shapes and instabilities. Our approach will focus on numerical methods, validated through theoretical and experimental analysis. Mathematically fluid-structure interactions involve ambitious moving boundary problems, where structure and fluid flow feedback on one another in complex ways. Detailed analysis requires precise modeling of coupling between very strongly de¬forming elasto-plastic solids and fluid flow in intricately curved spaces and solving both iteratively many times. To address this computational challenge, significant innovations will be implemented, including the use of novel erosion laws, the insertion of spatial curvature and metric directly into the equations of motion of the fluid, and special methods to handle the singular behaviour at kinks and constrictions. Our fluid solvers will be new variants of Lattice Boltzmann Models (LBM) coupled to temperature and concentration fields. The accuracy of the methods will be quantitatively validated by experiments. An unconventional hydrodynamic formulation for electronic currents will provide big advantages. We will develop LBM solvers for quantum and relativistic fluids and in particular create a Lattice Wigner model and couple it to the molecular dynamics of the support. Our method will open new horizons for the design of continuously regenerating filters, for shape optimi¬zation of heat exchangers and catalysts and for the engineering of electronic devices. Our approach will also shed light on sand avalanches in oil extraction, on aspects of folding in living matter, and on electromechanical instabilities.",Fluid Flow in Complex and Curved Spaces,FP7,31 December 2017,01 January 2013,2200000.0 FIBCEM,Cembrit Holding SA,construction,"Fibre Reinforced Cement (FRC) is a durable, fire and corrosion resistant material widely used in the construction industry. Coupled with the low cost of Portland cement, these properties make it ideally suited for applications such as roofing tiles and sidings. However the production of cement is associated with a large CO2 ‘footprint’, for each tonne of cement produced nearly one tonne of CO2 is emitted. This has resulted in FRC becoming stigmatised as a ‘dirty’ material. In addition the high density of cement and hence FRC products results in high transport costs for the producers and high end user installation costs.",Nanotechnology Enhanced Extruded Fibre Reinforced Foam Cement Based Environmentally Friendly Sandwich Material for Building Applications,FP7,11 June 2016,12 January 2011,0.0 FIBROGELNET,Institute for Bioengineering of Catalonia * Institut de Bioenginyeria de Catalunya (IBEC),health,"High incidence of degenerative skeletal tissue disorders in a progressively aging human population make tissue engineering of cartilage and bone a focus of extensive research. Bone and joint disorders are the most common disease in Europe: more than 100 million European citizens suffer from arthritis and 19 million people have osteoporosis (one of three women and one of eight men are affected). This proposal is designed to supplement the existing EuroNanoMed project aimed to develop an innovative strategy for targeting bone and cartilage regeneration. More specifically the proposal seeks to set up an international multidisciplinary team of young scientists and engineers representing both academia and industry partners that will strongly contribute to the design of a novel type of implant, which can strongly promote tissue regeneration combining high performance materials, advanced nanotechnology and living cells.",Network for Development of Soft Nanofibrous Construct for Cellular Therapy of Degenerative Skeletal Disorders,FP7,31 December 2016,01 January 2013,910726.0 FIN,University of Nottingham,health,"At the heart of this multi-disciplinary research project lie two emerging prominent theoretical models developed by the applicant in the past 12 months, which underpin the fundamental interactions taking place at the nanometre scale. In 2010, the applicant proposed a general solution to the fundamental problem of the attraction between like-charged dielectric nanoparticles. This is the first time a comprehensive solution to this problem has been presented, and it has the potential to transform our understanding of how charged nanoparticles interact in the gas phase and solutions. Studies of nanoparticles have opened new avenues for exploration of the principles that underpin the transition from the gas phase to the solid state. The capability of nanoparticles to modify their shape in order to minimize the free energy leads to structure modifications that can be observed on a time scale accessible by electron microscopy techniques. A unique computational methodology has been developed by the applicant, which has an advantage over the state-of-the-art image simulation techniques in its ability to simulate the dynamics of structural transformations under the influence of the electron beam. The proposed core theoretical frameworks are central tools of the project. Their fundamental nature offers solutions to problems across wide-ranging disciplines. The models will be advanced during the project and introduced to the experts in the application areas in order to find solutions to a number of common problems, which to date remain un-solved. The application areas, which will be addressed, include the electrostatic charging of pharmaceutical powders during manufacture and handling; the charge scavenging in the formation of solar systems; self-assembly of charged nanoparticles in solutions; proton transfer in biological molecules; structure-property correlations of nanomaterials; and design of innovative oxidation catalysts using inorganic polyoxometalates.",Theory of Fundamental Interactions at the Nanoscale,FP7,31 December 2017,01 January 2013,1400341.0 FIND AND BIND,University of Minho * Universidade do Minho,health,"Living cells are complex entities with remarkable capacity to sense, integrate and respond to environmental cues. The term directional sensing refers to the ability of a cell to determine the direction and proximity of an extracellular stimulus and to convert this information into biochemical signals. So far, the mechanisms of this extremely complex process are to be elucidated. Undoubtedly, carbohydrates are a class of molecules which together with the proteins span a large spectrum of these mechanisms: from those that are trivial to those that are crucial for the development, growth, function or survival of an organism. Find and Bind aims to explore the potential of this class of molecules to mediate specific recognition events and therefore to provide modulation of biological processes. Approaching and employing the nanoscale mechanisms of the interactions of cells and their physiological milieu Find and Bind will create biological design criteria for the development of new materials and devices constructed from these materials. Taking the cell-matrix adhesion to the third dimension by re-creating both signals and timing of natural occurring events will be applied to develop third generation polysaccharide based constructs. Combining nanostructured scaffolds from naturally derived polymers and the incorporation of biological signals will provide inherent informational guidance in recreating cell-cell interactions and control tissue formation in vitro and in vivo. The long-term innovation potential of the developed constructs as (i) 3D cell instructive materials able to restore and enhance the functions of healthy tissues; (ii) Biosensors and (iii) Surfaces for selective differentiation of stem cells will also be in the targets of this proposal.",Find and Bind: Mastering sweet cell-instructive biosystems by copycat nano-interaction of cells with natural surfaces for biotechnological applications,FP7,30 September 2013,01 October 2009,3594828.0 FINELUMEN,National Research Council * Consiglio Nazionale delle Ricerche (CNR),photonics,"'FINELUMEN' is a 4-year project aiming at the preparation and extensive characterization of luminescent materials in which suitably designed organic and inorganic luminophores are encapsulated within nano-containers (carbon nanotubes and coordination cages) in which they can preserve and even improve their emission output. The ultimate goal is to create a library of luminescent modules emitting throughout the VIS-NIR region for producing superior functional hybrid materials. The emission colour tunability is defined by the emitting guest, while the versatility in the final application is controlled via tailored chemical functionalisation of the host. The versatile properties of these materials will make them attractive in at least 3 applicative areas, i.e. bioimaging, optoelectronic devices and sensors. The participation of a giant company and a high-tech SME in the consortium ensures a quick patenting and industrial scale up of the most promising luminescent materials, strengthening Europe's competitiveness in a field of huge growth potential in the next decade. The research endeavour inside 'FINELUMEN' calls for a multidisciplinary team in which key groups, experts in many different fields of chemistry, physics and engineering tightly interact. For this reason training and exchange of young researchers represents the core of the'FINELUMEN' activity To both early-stage and experienced researchers, a multidisciplinary training in the realm of synthetic/supramolecular/physical chemistry, photosciences, and engineering as well as management, communication, and IPR is offered, preparing them for positions in academia, industry, and government labs. The local and network-wide training and transfer of knowledge activities are strengthened by 2 authoritative visiting scientists, enriched by 3 FINELUMEN international summer schools and conferences, and complemented via PhD programmes in co-tutoring among partners based in different countries.",Cavity-confined Luminophores for Advanced Photonic Materials: A Training Action for Young Researchers,FP7,30 September 2012,01 October 2008,3616956.0 FINFLASH,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The FinFLASH project aims to study a new cell architecture to overcome the scaling limits of FLASH memories beyond the 28 nm technology node (year 2015 and after). The new idea is to evaluate the potentialities of the FinFET, one of the non-classical advanced MOSFETs that provides a path to CMOS scaling to the end of the RoadMap, for FLASH memory application. Main challenge will be the optimization of the device structural design to achieve NVM functionalities. Additionally, the introduction of new materials will enable new operating principles that may provide new behaviour and functionality beyond the constraints of classical FLASH memories. The FinFLASH approach is promising both for stand-alone NVMs, due to the extremely compact memory cell size, and for the embedded ones, due to the intrinsic compatibility of the FinFLASH process with the one of FinFET logic devices. The main objectives will be: 1) Study on the most promising charge storage media and device designs; 2) Evaluation based on single cells and arrays of FinFLASH devices; 3) Definition of program/erase schemes at ultra-short channel lenghts; 4) Development of comprehensive and predictive models both at the device and circuit level; 5) Simulation and optimization of FinFLASH devices using TCAD tools. During the first year preliminary evaluations of multi-gate device structural design will be made by advanced 2D/3D TCAD simulations. At the same time, the development of the critical technological modules will be treated. Both deep UV and e-beam lithography will be adopted to realize devices, on Si-bulk and SOI, with minimum size of 25 nm x 25 nm. A detailed electrical and microstructural evaluation of the devices will be performed. During the second year of the project, a second run of devices will be done, allowing for the evaluation of optimized FinFLASH cells and small arrays. The optimized structures will also include new materials for the gate stack like high-k dielectrics and metal gates.",FINfet structures for FLASH devices,FP6,31 August 2007,31 May 2005,2526674.0 FINON,Chalmers University of Technology * Chalmers Tekniska Högskola,health,"The aim of this ITN is to take the category of Nonlinear Optical Microscopy (NOM) techniques into the nano-dimension, allowing for label-free three-dimensional (3D), dynamic imaging of macromolecular arrangements and nanostructures by probing inherent higher-order electronic and molecular vibrations with novel detection concepts. Specific S&T objectives are to (A) explore the use of nano-sized scanning probes, polarization or phase resolved detection schemes to enable nano-scale imaging, (B) benchmark their capabilities by fundamental studies and computations of molecular suprastructures and metallic nanostructures, and to (C) apply them in live-cell and fuel cell studies in order to introduce them as attractive instruments for the pharmaceutical-, nanotechnology-, and biosciences/industry. In particular, we will study (i) the formation of hierarchical structures of beta-amyloid, (ii) nonlinear emission by metallic nanoparticles/holes/antennas as potential nano-photonic devises, (iii) stem cell differentiation and metabolic expression in a 3D tissue model for drug screening and (iv) physic-chemical processes in fuel cell membranes. This sets requirements on a highly interdisciplinary and intersectoral working process. Consequently, the FINON ITN constitutes of partners from, and active interaction between, a wide range of disciplines spanning from front-line technology developers of laser instrumentation, microscopy, and nanophotonics to users of microscopy with extended experience and challenging requirements within the life-, chemical-, pharmaceutical- and material sciences. This forms an attractive training environment, with particular emphasis on early-stage and experienced researchers, offering unique networking opportunities and a vast variety of career paths.",Female Investigators in Nonlinear Optical Nanoscopy - FINON,FP7,30 September 2017,01 October 2013,3470652.0 FIREFLY,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,photonics,"The objective of FIREFLY is the introduction of novel polymer waveguide and photonic crystal structures based on highly structured 3D nano-hybrids into industrial applications by using a new cost effective production process for larger scale manufacturing. The target applications are optical waveguides and photonic structures for the manipulation of light in, for example, optical interconnects. The optical interconnects technology will initially be applied for data communication in high performance supercomputers, and eventually these optics will also find their way into high-end server systems, mid-range servers and in consumer-like applications such as high-end multimedia devices. Waveguides and photonic crystals based on polymers have been proven in a laboratory environment to be interesting technologies for light management. In most cases these structures are manufactured on small scale. We propose the use of a relatively new technology to manufacture these structures on a larger scale. The nano-hybrids will be manufactured using a combined approach of nano-imprint process in a polymer resins and self assembly of material in the polymer nano-structures. The nano-structures will be filled with new modified polymer compositions having a high refractive index and optical clarity at relevant wavelengths, necessary for waveguides, and with inorganic nanoparticles to prepare photonic crystals, for the manipulation of light for guiding the light in waveguides through sharp horizontal and vertical bends. Some material developments are needed: new silicone polymers that will be modified for improved optical properties such as low optical loss and tuneable refractive index, and new inorganic particles that will combine a high refractive index with a very high level of monodispersity. The manufacturing process will be suitable for up-scaling to an industrial process. This new bottom-up approach will enable the development of hybrid materials with new optical properties.",Multilayer Photonic Circuits made by Nano-Imprinting of Waveguides and Photonic Crystals,FP7,30 November 2014,01 October 2011,3419215.0 FISHTIO2,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,environment,"The nano-ecotoxicological research is supported and promoted by European Commission. In 2005, the Action Plan “Nanosciences and nanotechnologies: An Action Plan for Europe 2005–2009” was adopted (European Commission, 2004). The European Commission clearly states the need for the new scientific experiments that will provide quantitative data on toxicology and ecotoxicology and allow for the risk assessments to be carried out on nanomaterials. In year 2006 the Chemicals Committee of the OECD has formed special Working Party on Manufactured Nanomaterials [WPMN]. One of the nanomaterials included in the OECD WPMN priority list is titanium dioxide (TiO2). Titanium dioxide nanoparticles (nano-TiO2) present the biggest ecotoxicological concern due to the rapid increase of anthropogenic input into the environment. Estimated environmental concentrations of nano-TiO2 in water range from 0.7 to 24.5 ng/mL.",TITANIUM DIOXIDE – THE SILENT KILLER: FINDING THE RELEVANT BIOLOGICAL TARGET FOR EXPOSURE CHARACTERIZATION AND RISK ASSESSMENT OF NANOPARTICLES TOXICITY IN FISH MODEL,FP7,08 July 2019,09 January 2013,0.0 FISNT,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,photonics,"In the last decade, Silicon Photonics has been a rapidly growing field fueled by the promise of highly scalable, ultra-low power, high bandwidth and low cost silicon based optical communication systems. The last few years have seen the emergence of several dedicated world-class research groups, a dedicated international conference, heavy investments by the semiconductor industry giants, multiple private equity funded start-ups, as well as dedicated multi-user foundry services. Nevertheless, several critical roadblocks remain that have so far prevented the field from displacing older optical technologies, the resolution of which presents extremely challenging scientific challenges, requiring highly innovative devices and system architectures as well as bleeding edge process development. In a nutshell, state-of-the-art Silicon Photonics remains marginally too expensive for ultra-short distance links, too low performance for long haul communications, and still has too high a power consumption to displace electrical interconnects at the circuit board level. It is the goal of this proposal to reach three key milestones that in the applicant's opinion are critical enablers for the field on its path towards becoming a truly disruptive technology.",Frontiers of Integrated Silicon Nanophotonics in Telecommunications,FP7,30 September 2016,01 October 2011,1917080.0 FLAGELLA,Aix-Marseille Université * Aix-Marseille University,health,"The locomotion of microorganisms in fluids is a theme of major importance in biology. It affects many processes such as mammalian reproduction, the marine life ecosystem, and the dynamics of bacterial infection. Locomotion is typically achieved by the periodic deformation of flagella (short and flexible organelles) that drive the fluid motion around the microorganisms, and generate propulsive forces. The shape of the flagella is, in turn, affected by the fluid dynamics forces generated by the organisms. The understanding of this complex fluid-structure interaction calls for a multidisciplinary approach, at the intersection of physics, mechanics, biology and applied mathematics. The present research and training project will be dedicated to some open fundamental issues of flagellar propulsion. One key point of its methodology is the combined experimental and theoretical approach. A macroscopic experiment will be built with the aim of mimicking the motion of a bacterial flagellum. By immersing a rotating flexible filament in a highly viscous fluid, the fluid mechanics is identical to what occurs at the microorganism scale but with the advantages of a perfectly controllable experiment. Several important phenomena will be studied independently such as the motion in a viscoelastic fluid, the interaction of several flagella, the mixing properties of the fluid dynamics, and the effect of intrinsic curvature on the propulsion efficiency. In parallel, theoretical models will be developed with the aim of providing deeper insight into the physical mechanisms by extending the regimes of the actual models (resistive force, and slender-body models). This proposal is related to important Health issues such as bacterial infection, sperm motility and the design of micro-robots able to perform minimally invasive surgery and targeted drug delivery. This project will therefore contribute to European competitiveness on two major themes of the FP7 Programme: Health and Nanosciences.",Fluid Mechanics of Flagellar Propulsion,FP7,31 May 2013,01 October 2010,181726.0 FLARETPOL,University of Milan * Università degli Studi di Milano,transport,"Plastic applications such as indoor elements of vehicles or aircrafts require flame retardancy to improve survivability. Emission of smoke or toxic gases should be also suppressed, making undesirable the use of some of the most efficient flame retardants, brominated compounds, which are even the object of European bans. Flame-retarded polypropylenes are highly sought due to the outstanding characteristics of PP, the fastest growing commodity plastic. The most promising flame retardant for polypropylene is magnesium hydroxide (MH), stable at PP processing temperatures and leading to harmless combustion products. Unfortunately, MH must be used in large amounts leading to a loss of processability and mechanical properties. The aim of Flaretpol is to achieve MH/PP composites with flame retarding behaviour, but much improved regarding processability and mechanical properties. Target properties for MH/PP will be V0 (UL94), stress at failure>16 MPa, strain>5%, E=1000 MPa, Impact>22.5 J/m, and success will be demonstrated by production of cables, profiles and car details. Sophisticated MH surface engineering techniques will be used, including direct coupling to the MH of tailor-made reactive peroxide oligomers (route 1), creation of a nano-sized tailored polymer layer around the MH (route 2) and combination of MH treated by routes 1 and 2 with treated nano-clay (route 3). The most relevant milestones include success in the filler treatment at laboratory level, successful industrial upscaling, production of cables, profiles and car details fulfilling specifications and demonstration of economic and environmental feasibility of the products and processes developed. The proponent consortium comprises 7 industries, 4 research organisations and 1 University from 7 European countries which cover all complementary aspects of production of MH/PP composites. Potential direct benefits include a revenue of 11 million Euros/year for the industrial partners.","DEVELOPMENT OF AN INNOVATIVE, COST-EFFECTIVE TECHNOLOGY TO PRODUCE HALOGEN-FREE, HIGH-PERFORMANCE FLAME RETARDED POLIOLEFINS (FLARETPOL)",FP6,30 September 2008,01 April 2005,2107000.0 FLATRONICS,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"The main objective of this research proposal is to explore the electrical properties of nanoscale devices and circuits based on nanolayers. Nanolayers cover a wide span of possible electronic properties, ranging from semiconducting to superconducting. The possibility to form electrical circuits by varying their geometry offers rich research and practical opportunities. Together with graphene, nanolayers could form the material library for future nanoelectronics where different materials could be mixed and matched to different functionalities.",Electronic devices based on nanolayers,FP7,08 July 2016,09 January 2009,1799996.0 FLEX-EMAN,Planer PLC,information and communications technology,"The electronics manufacturing sector has seen significant changes over the past two years. Volume manufacturing has become a commodity service resulting in: creation of multinational manufacturing service providers; migration of volume operations to low-cost locations external to EC and the evolution of manufacturing technology only ideally suited to high volume production. The future of the industry will be based in an evolving, dynamic SME community. SME manufacturers survive ';by providing low-volume, high variety, mixed-batch manufacture or production of niche and high-value added products. This community faces challenges from market, manufacturing technology and legislative pressures. The pressures of mass-customisation, decreasing life cycles and integration of multifunctional features, such as MST and MEMs technologies, requires the adoption of sophisticated manufacturing capabilities with flexibility to. cope with a broad mix of products and volumes. Manufacturing technology has evolved towards efficiency in volume production, with scant regard to flexibility and rapid changeover for lower volume production. Agility will be a key element to SME survival and future investment. The WEEE directive banning lead requires SMEs to adopt new manufacturing practices, requiring another dimension of flexibility in capability and potential cost impacts from expensive consumables (N2) and higher energy requirements. The lead-free changeover also requires the understanding of these materials in production and product life-cycle. Flex-eman offers a solution to these challenges by utilising individual precision soldering chambers combined in a work-cell serviced by intelligent materials handling and control systems. This replaces an inflexible production process with an agile system, specifically designed jor cost-efficiency in manufacture of mixed product and batch sizes. The system is inherently fault-tolerant, eco-friendly and incorporates state of th",Flexible soldering cells for agile electronics (FLEX-EMAN),FP6,27 February 2007,29 November 2004,165059.0 FLEXIDIS,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,information and communications technology,"Integrated Project 'Flexible Displays', or FlexiDis, has the realization of flexible active-matrix displays as its primary goal. The aim of this project is to coordinate a balance of experimental, numerical and demonstrator vehicle development for identifying and researching the main issues for flexible displays. This will include the materials and processing technology, physical studies of the mechanical properties and materials behavior of multilayer structures during processing, under flexing, and during service-life, novel fabrication tools, and substrate handling procedures to make and introduce reliable, flexible active-matrix displays to the market. The demonstrator vehicles will work with two different display technologies, namely full-color organic light-emitting displays (OLED) on bendable metal and/or plastic foils with inorganic thin-film driving transistors, and monochrome electrophoretic (EP) displays on rollable plastic substrates with organic thin-film driving transistors. In this way, use for automotive, mobile telecommunications, and toys can be examined. FlexiDis will strengthen ties between leading European research efforts in different disciplines and build a common standard for flexible display reliability, testing methodologies, and substrate handling in Europe and lead to implementation of these novel displays in applications.",Flexible Displays,FP6,31 March 2008,30 September 2004,1.432E7 FLEXIFUNBAR,Duflot Industrie SA,transport,"All citizens are permanently protected by flexible structures with barrier effect: fire retardancy, noise and thermal insulation, shield against electrostatic or electromagnetic phenomena, filtration of dust or insects... The application of flexible structure is very large thanks to their easy adapting properties and shape. The flexible structures, generally based on paper, leather or textile are usually treated to serve only one barrier effect. Nevertheless, the will to maximise the level of safety in building, transportation and to ensure the well-being of European citizens, requires a whole re-design of flexible structure functions that is the main purpose of FLEXIFUNBAR. For instance to prevent from all external aggressions in hazardous atmosphere, flexible structures must provide at least three banier effects. Concretely as an example, a filter dedicated to transportation could all-in-one: - trap pollen, dust particles with diameter lower than 0.2 microns, even if the concentration is less than 20 micrograms. - prevent from fire, during 30 seconds under a heat flux equal at 20kW/m2. - prevent diffusion of toxic gas and pollutants like carbon monoxide in automotive interiors. fhe textile, paper and leather are traditional industrial sectors that involve a large majority of high tech SME's. That is why FLEXIFUNBAR has been especially dedicated to SME's. The specific topic in the \"2003 NMP Nanotechnologies, Materials and Production processes\" call fits perfectly the content and objectives of the proposed integrated project. The brief following description of objectives summarises the relevance of Flexifunbar to priority 3 : 1. The ultimate goal of Flexifunbar initiative is to develop innovative generation of hybrid multi barrier-effect materials, based on multi layer complex structures and functionalisation of micro and nanostructures.","MULTIFUNCTIONAL BARRIERS FOR FLEXIBLE STRUCTURES (PAPER, LEATHER, PAPER)",FP6,30 September 2008,01 October 2004,6438995.0 FLEXNOLEAD,TWI Ltd.,information and communications technology,"Flexible circuit boards are a functionally pivotal and rapidly growing technology for electronics goods. Applicationsinclude: computer peripherals (e.g. flat panel displays, ink-jet printers, disc drives), hand held devices (e.g. GPS, personaldigital assistants, membrane keyboards), telecommunications (mobile phones), automotive (e.g. engine controls,dashboards/connections), smart cards (antenna foils), aerospace (lightweight, compact systems) and medical devices (e.g.sensors). The drive to use flexible circuits is based on the technologies ability to: reduce size, weight, assembly time andcost, accommodate relative movement between component parts, increase system reliability (reduced interconnect), improvecontrolled impedance signal transmission and heat dissipation and enable three dimensional packaging.These benefits have resulted in a significant increase in the use of flexible circuits for electronics and systems assembly,particularly consumer products. The global market size has been estimated by various bodies to be between 4 billion to 7billion with anticipated growth rates up to 15% per year.Flexible circuits are most commonly manufactured using one of two base materials, either polyimide or polyester. Theformer is favoured where soldering is required, the latter is generally used in low cost applications. Both flexible circuitmaterial systems are sensitive to temperature (continuous service temperature: polyimide ~177C, polyester ~74C), whichraises considerable concerns as to their capabilities of withstanding the higher soldering temperatures, which will beimposed by lead-free solder and its impact on their operating properties. As flexible circuits are developing into such asignificant technology for electronic products, with a major role in manufacturing and assembly being played by SMEs, it isessential that an understanding of the impact of this major change in technology on flexible circuits is #","Flexible Circuits Processing, Performance and Reliability using Lead-Free Soldering Process",FP6,30 April 2007,01 February 2005,1045878.0 FLEXOELECTRICITY,ICN2 - Institut Català de Nanociència i Nanotecnologia,health,"Flexoelectricity is a general property of all insulators whereby they generate a voltage when subjected to an inhomogeneous deformation such as bending. Research on this property has taken off with the observation that, due to the large gradients they can accommodate, devices operating in the nanoscale display colossal flexoelectric effects. The present proposal aims to set up Euroe's first laboratory specialized on the exploration and exploitation of flexoelectricity. It shall focus on three areas with specific targets: 1) Flexoelectricity for energy harvesting: the inverse relationship between flexoelectricity and device size means that, at the nanoscale, flexoelectric energy harvesting can deliver electromechanical performances superior to the current state of the art. We aim to demonstrate record-high effective piezoelectric coefficients through the use of flexoelectricity. 2) Flexoelectricity for information technologies: Flexoelectricity affords mechanical control of polarity. This opens the door to novel memory device concepts where polarization (and magnetization) can be controlled by pushing with the tip of a scanning probe. We aim to achieve flexoelectric writing of domains under electrodes, and also to demonstrate the indirect coupling between flexoelectricity and magnetization ('flexomagnetism'). 3) Bioflexoelectricity: Flexoelectricity participates in human hearing, and is expected to participate in other bioelectric phenomena. In particular, bones are known to generate electricity in response to stress, and it has been hypothesised that this is due to strain gradients; if demonstrated, this would represent a significant step towards osteogenetic implants. Determining the role of flexoelectricity in in bone piezoelectricty will be the third aim of this project.",Flexoelectricity,FP7,31 December 2017,01 January 2013,1478400.0 FLEXONICS,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,information and communications technology,"Flexible electronic devices (FEDs) will have a major impact in our daily life if we succeed to encapsulate them into transparent, ultra-high barrier, flexible materials, providing protection against oxygen and vapor, long-term stability and endurance. The realization of such materials, compatible with roll-to-roll (r2r) production processes will allow cost effective large scale FEDs production. FLEXONICS goals are to develop: 1) materials systems consisting of alternating inorganic/organic layers few nm thick to improve the current barrier properties of flexible films by at least a factor of 1000, 2) the relative r2r processes, which will be used for the production of such materials, 3) optical real-time techniques for process control and optimization, with final and specific goal the effective encapsulation of flexible OPV and OLED devices. The above objectives conform to the NMP activity on 'Materials processing by radically innovative technologies'. The project will extend our knowledge on hybrid organic/inorganic systems, their interfaces and their optical and barrier properties. New techniques will be developed to measure and model the ultra-low gas permeation. Finally, the optical properties of the hybrid organic/inorganic layers and the light interaction with complex-structured materials will be studied at the fundamental level.The duration of FLEXONICS is 36 months; the project involves 5 leading industries (vacuum equipment and optical instrumentation providers, polymer film producers and converters, producers of electronic devices) and 3 research organizations. The deliverables of the project include: 1)ultra-high barrier organic/inorganic materials, 2)production process for such materials, 3)modeling of permeation mechanisms, 4)new techniques for permeability measurements, 5)modeling of the light interactions with complex structures, 6)new optical instrumentation for process control, and 7)demonstration of operational FEDs properly encapsulated.",Ultra-high barrier films for r2r encapsulation of flexible electronics,FP6,31 January 2008,01 February 2005,2817750.0 FLEXPAKRENEW,"Technical Center for the Paper Industry, Cartons and Celluloses * Centre Technique de l'Industrie des Papiers, Cartons et Celluloses",environment,"The objective of this project is to design and to develop an innovative ecoefficient low-substrate flexible paper for packaging from renewable resources to reduce the packaging industry’s reliance on barrier films derived from petroleum. The challenge of this project is to develop a flexible packaging paper, with barrier properties (grease, water, oxygen and water vapour barrier) competitive with those of untreated plastic films (medium barrier) or to treated plastic films (high barrier). This paper will be developed using renewable materials, beyond state-of-the-art barrier coatings and innovative surface treatment processes. The main scientific advances concern: 1-The development of a substrate with significantly enhanced barrier properties via knowledge-led improvement and innovation such as the use of selected materials in the bulk and the deposition of a thin film of renewable materials during the paper forming. 2-Development of water borne coatings made from renewable materials (starches, functionalised starches, starch derivatives or modified hemicelluloses) and reinforced by (low eco-footprint) minerals or renewable nanoparticles to optimise the desired properties. 3-Development of high barrier paper arising from innovative surface treatments: Solvent free chemical grafting and vacuum coating. These two techniques, although based on very different principles, enable the deposition of nanolayers (a few molecular layers) that drastically improve the barrier properties. 4-Development of a new type of antibacterial coatings to prolong food quality. Particular attention will be paid to sustainability assessment and life cycle analysis throughout the project. A substantial reduction in the amount of packaging going to landfill is envisaged, together with speedier environmental degradation of the packaging materials. This project will make a significant contribution to reduce the reliance on petroleum resources during packaging production.",Design and development of an innovative ecoefficient low-substrate flexible paper packaging from renewable resources to replace petroleum based barrier films.,FP7,08 July 2013,09 January 2008,3276000.0 FLUMABUD,Curie Institute * Institut Curie,health,"Enveloped viruses, such as influenza, acquire their outer lipid envelope by budding from the membrane of the infected host before being released in the extra-cellular space by membrane fission. In these last steps of the virus infection cycle, matrix proteins connecting capsid with the lipid envelope often play a key role in assembly and budding of newly produced virions. In spite of the widely acknowledged impact on public health and economy of influenza epidemics, the processes facilitating egression of the flu virus are only poorly understood. The goal of this project is to investigate the mechanisms by which Influenza escapes from its host. We will, in particular, focus on the role of its matrix protein M1. Our approach is based on the use of a combination of minimal cell membrane models produced in vitro upon self-assembly of lipids. Using supported lipid bilayers (SLB), giant unilamellar vesicles (GUV), as well as membrane nanotubes of compositions reflecting those of the host´s plasma membrane, we will provide a physical understanding to the role of M1 in facilitating virus assembly into a bud and release from the host. Through our study, we will elucidate whether M1 can promote budding and fission via scaffolding and whether the formation of lipid microdomains can help overcoming the energy barrier required for membrane abscission. Once the system is established, it will be extended to mimic the role the riboneucleoproteins core (RNPs), using nanoparticles of geometries similar to the viral capsid. Furthermore, the contribution of other viral components will be taken into consideration. In particular, we will look for a synergy between M1 and the ion channel M2 as the latter is believed to be involved in fission. A detailed understanding of the individual steps of the viruse's life cycle is not only interesting from a fundamental point of view but is likely to greatly benefit to the development of more efficient antiviral drugs and treatments.",The role of the influenza virus matrix protein M1 in budding adn virus release,FP7,31 August 2015,01 March 2013,202405.0 FLUOROCODE,University of Leuven * Katholieke Universiteit Leuven,health,"There has been an immense investment of time, effort and resources in the development of the technologies that enable DNA sequencing in the past 10 years. Despite the significant advances made, all of the current genomic sequencing technologies suffer from two important shortcomings. Firstly, sample preparation is time-consuming and expensive, and requiring a full day for sample preparation for next-generation sequencing experiments. Secondly, sequence information is delivered in short fragments, which are then assembled into a complete genome. Assembly is time-consuming and often results in a highly fragmented genomic sequence and the loss of important information on large-scale structural variation within the genome. We recently developed a super-resolution DNA mapping technology, which allows us to uniquely study genetic-scale features in genomic length DNA molecules. Labelling the DNA with fluorescent molecules at specific sequences and using high-resolution fluorescence microscopy enabled us to produce a map of a genomic DNA sequence with unparalleled resolution, the so called FLUOROCODE. In this project we aim to extend our methodology to map longer DNA molecules and to include a multi-colour version of the FLUOROCODE that will allow us to read genomic DNA molecules like a barcode and probe DNA methylation status. The sample preparation, DNA labelling and deposition for imaging will be integrated to allow rapid mapping of DNA molecules. At the same time nanopores will be explored as a route to high-throughput DNA mapping. FLUOROCODE will develop technology that aims to complement the information derived from current DNA sequencing platforms. The technology developed by FLUOROCODE will enable DNA mapping at unprecedented speed and for a fraction of the cost of a typical DNA sequencing project. We aniticipate that our method will find applications in the rapid identification of pathogens and in producing genomic scaffolds to improve genome sequence assembly.",FLUOROCODE: a super-resolution optical map of DNA,FP7,31 August 2017,01 September 2012,2423160.0 FLUOROMAG,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The objective of FLUOROMAG will be to (a) produce noble metal nanoclusters or nanodots, (NDs), and core-shell (CSs) nanoparticles by a new method using controlled electrochemical techniques that ensure very uniform size distributions and transfer of this technology to a dedicated SME who will scale up the synthesis of these nanoparticles for commercial production as well as supply the consortium with NPs for characterization of their extinction, fluorescent and magnetic properties and the further development of diagnostic tests. (b) devise conjugation strategies to couple biomolecules to noble metal NDs and commercially available quantum dots, (QDs) to produce probes that can specifically target macromolecules such as proteins and DNA/RNA in vitro and in cells and tissues. We will take advantage of ND electrochemical synthesis to introduce specific molecules in the shells that permit efficient derivatization and coupling to biomolecules. (c) develop multiparametric diagnostic assays using combinations of bioconjugated QDs and noble metal NDs as novel, fluorescent probes, and bioconjugated noble metal nanoparticles as extinction probes. The goal is to achieve high sensitivity (down to single virus detection) in molecular and cellular recognition. New Hepatitis C, Dengue Fever and breast tumor assays are proposed that will monitor several antigens in multiplexed kinetic and end-point determinations. (d) develop a commercial, low-cost programmable array microscope (PAM) module for wide field microscopes with SME partner which utilizes a spatial light modulator to achieve high-speed sectioning and simultaneous measurement of multiple fluorescence modalities as a detection system for single and multiplexed diagnostic assays using nanoparticles developed in a-c for the health-care market.",Multiparameter sensing for high sensitivity diagnostics using fluorescent and magnetic nanoparticles,FP6,30 April 2010,01 November 2006,2552300.0 FLUOSYNES,Pierre and Marie Curie University * Université Pierre et Marie Curie,energy,"Metal fluorides display numerous fields of applications which have been boosted by the emergence of fluorine nanochemistry. This proposal aims to develop new synthesis method to prepare nanosized metal fluorides with an emphasize on the understanding of the crystal formation. This will allow a fine control of the chemical composition/structure as well as the morphology of the prepared solid which is to be used in electrochemical devices, notably Li- and Na-ion batteries. Furthermore, a mechanistic investigation of Li and Na storage capacity in such materials will be conducted through advanced physico-chemical characterizations tools (synchrotron, NMR, etc). Finally, in marge of fundamental studies, the final aim of this work is also to propose a battery prototype and to provide a scalable method to prepare new class of fluorinated materials for next generation of electrode materials having high energy density.",New nanosized metal oxy-FLUOrides: tailored SYNthesis and Energy Storage,FP7,31 August 2016,01 September 2012,100000.0 FLYING WAFER,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"This project is part of a joint European activity which targets at inter-linking the European RandD Centres of Excellence in micro and nanotechnologies to a virtual 300 mm CMOS RandD line. The core partners include industrial 300 mm research sites and pilot lines as well as the major European RandD institutes Fraunhofer, IMEC and LETI. The goal of this project is to enable, on a short term, the co-operation of the European RandD centres by providing a fast and reliable logistic and infrastructure for exchange and transfer mechanism of 300 mm wafers between the RandD sites. Thus, existing 300 mm processing capabilities, newly purchased standard 300 mm equipment and highly innovative alpha or beta site tools finally can be interlinked to a full CMOS RandD line. Furthermore, data about the current status and location of wafers and carriers needs to be tracked, monitored and administrated in a joint database and made securely accessible by all partners via the internet. Demonstrating the feasibility of inter-linking the already existing European RandD Centres of Excellence within the framework of this project should cost-effectively enable in fact the availability of a virtual European 300 mm CMOS RandD line as early as 2005/2006.",Feasibility Study for a 'Flying Wafer' Concept to Implement a European Virtual 300mm RandD-Line,FP6,30 September 2005,30 December 2003,999802.0 FMCOBE,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"Fluid mechanics are fundamental to collective behaviour in nature and technology. Fluids pervade complex systems at every scale, ranging from fish schools and flocking birds to bacterial colonies and nanoparticles for drug delivery. Despite its importance, little is known about the role of fluid mechanics in such applications. Is schooling the result of vortex dynamics synthesised by individual fish wakes or the result of behavioural traits? Is fish schooling energetically favourable? How does blood affect the collective transport of nanoparticles in cancer therapy? We seek to answer these questions through computational methods that resolve the interaction of fluids with multiple, deforming bodies across scales. Our methods rely on the innovative coupling of multi-scale particles with multi-resolution algorithms and grids. Uncertainty quantification techniques will link computations with experimental data. Learning and optimisation algorithms will investigate the optimality of collective behaviour and its relevance to technological applications. Novel, scalable software, engineered to facilitate its broad use, will be made available to the scientific and industrial community. Our group has built strong foundations in computational methods, fluid mechanics, biophysics, nanotechnology and their interfaces and this project gives us the opportunity to reach new frontiers. Our goal is to provide unprecedented information about vortex dynamics of fish schooling, one of the most intriguing patterns in nature. Increased insight will open new horizons for mechanical understanding of collective behaviour, suggest new experiments and contribute to the rational design of industrial applications ranging from robots to wind farms. We will also shed light on mass transport in tumour induced vasculature to enhance the efficacy of drug delivery by nanoparticles, one of the most promising routes for cancer therapy.",Fluid Mechanics in Collective Behaviour: Multiscale Modelling and Applications,FP7,31 March 2019,01 April 2014,2498800.0 FOAM-BUILD,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,construction,FoAM-BUILD will develop next generation External Thermal Insulation Composite Systems (ETICS) for new builds and retrofitting applications. This comprises innovations in:,Functional Adaptive nano-Materials and technologies for energy efficient BUILDings,FP7,08 July 2019,09 January 2013,0.0 FOCUS,Advanced International School of Advanced Studies * Scuola Internazionale Superiore di Studi Avanzati,photonics,"The present project, FOCUS, will build a novel generation of biologically inspired molecular devices (MDs) based on the developments of new photonic tools. These photonic tools will use Plasmon Polariton and two-photon technology, enabling focused light spots with a diameter around 10 nm. FOCUS will also develop new light sensitive molecules that will be selectively activated by our new photonic tools. These new technological innovations will provide a way to control activation of single light sensitive molecules and will allow the investigation of molecular computation in a biological environment and with an unprecedented resolution. On the basis of these investigations and by using the developed new tools, FOCUS will design and test new MDs for amplification and information processing. FOCUS will: i - provide new photonic devices to control single molecules; ii -lay out the basis for understanding molecular computation in biological systems; iii - provide proofs of concept and suggestions for designing new molecular artificial computing systems; iv- build prototypes of these new MDs. FOCUS has formed a highly interdisciplinary consortium composed of nanotechnologists able to fabricate the new photonic devices - i.e. Enzo Di Fabrizio (IIT), Alpan Bek (METU) and Marco Lazzarino (CBM), chemists able to develop the photoswitches and assemble the MDs -i.e. Pau Gorostiza (IBEC) and Ljiljana Fruk (KIT) and biologists able to understand molecular mechanisms -i.e. Vincent Torre (SISSA) and Fabio Benfenati (IIT). The two companies RappOptoElectronic and NT-MDT Europe BV will transform the new tools and devices into marketable products.",Single Molecule Activation and Computing,FP7,31 March 2014,01 January 2011,3174259.0 FORCEREGULATION,Queen Mary University of London,health,"Force is ubiquitous in nature and physical stimuli are crucial for cell function. How cells process forces determines key physiological processes such as cell growth and differentiation, in which cells divide or differentiate according to the chemical and physical cues cells receive from the extracellular matrix. Physical stimuli have also been involved in the development of pathological processes, especially those in which cells lose the proper physical communication with the environment, such as cancer and metastasis formation. The major components of the mechanotransduction signaling pathways that transmit and translate these physical messages will most likely to be the molecules that directly sense force from the extracellular matrix. These molecules are integrins and the proteins that link them to the cytoskeleton. Here, I propose a multidisciplinary approach aimed to elucidate how force can modulate cellular behaviour. The project will focus on (i) determining how cells sense, produce and interpret forces and (ii) the cellular outcomes resulting from these processes. First, a nanotechnological suite composed of magnetic tweezers, and siRNA technology will be developed and employed to determine the roles of the molecules involved in these mechanical pathways. Second, the molecular mechanisms that trigger the interaction of proteins under force application will be studied. Several biophysical techniques such as magnetic tweezers, Atomic Force Microscopy (AFM), Total Internal Reflection Fluorescence (TIRF), and Fluorescence Resonance Energy Transfer (FRET) will be used here. Finally, a comparative study of the effect of force in normal and malignant cells will be accomplished. It will be tested whether or not these pathways are involved in the expression of genes in the nucleus, and the ability of normal and malignant cells to respond to external forces and to apply forces on their substrates. Magnetic tweezers, and elastic pillars will be used here.",How force regulates cell function: a molecular and cellular outlook,FP7,28 February 2017,01 March 2012,1998331.0 FOREMOST,Fundación Tekniker,transport,"The overall objective of the integrated project is to provide industry with radically new composite coating systems, based on the incorporation of inorganic fullerene-like nanoparticles. The application of the composite coatings will be for surfaces and lubricants, in order to significantly reduce and control friction and wear in tribological contacts. The ultimate aim is to reduce friction as well as to extend operational life, reduce maintenance requirements and reduce the environmental impact of a wide range of mechanical elements for the aerospace, automotive, power generation (energy) and manufacturing industrial sectors. The new materials that will be developed can be grouped into three categories: Nanocomposite hard coatings, consisting of a hard matrix containing self-lubricant fullerene-like (FL) nanoparticles Polymeric coatings and paints incorporating the Fullerene-like nanoparticles Lubricants and greases containing fullerene-like nanoparticles for complex systems where only some parts can be lubricated or coated with the new nanocomposites These new materials will allow independent control of tribological properties usually known as antagonists (very high load bearing capacity with a very low friction coefficient). This breakthrough in coatings and materials design will mean a radical innovation in lubrication and wear protection concepts, rather than an incremental advance in either reducing wear or improving friction behaviour. Success will require the development of innovative coating processes and incorporation techniques for the production of these unique nano-composites. Although initial work will focus on the incorporation of existing inorganic fullerene nanoparticles with onion-like or nanotube structures, significant research effort will be concentrated on the discovery and development of new inorganic fullerene-like materials (IFLMs) to fulfil the expected industrial requirements.",Fullerene-based Opportunities for Robust Engineering: Making Optimised Surfaces for Tribology,FP6,28 February 2010,01 September 2005,1.159899999E7 FORK,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"Liquid Crystal on Silicon (LCOS) combines two very well-known technologies, namely the IC/CMOS and the Liquid Crystal (LC) technologies. As both of these are very mature, it is obvious that LCOS has a huge potential for very high-end applications, more than any other (projection) technology. The aim of the FORK project is the development of a LCOS microdisplay device for very diverse applications in simulation, medical imaging, control rooms and digital cinema. These applications require or benefit from very high pixel counts, high contrast ratio's, very high light fluxes and very good colour and brightness uniformity, analog pixel addressing and high response times. While some non-European suppliers have announced microdisplay devices for the applications mentioned above, we are not aware of any devices which meet all of these criteria. In order to meet all of these criteria, additional challenging research is needed in the field of LCOS backplane and driver design, LCOS backplane processing, IC (Integrated Circuit) stitching, new or improved Liquid Crystal (LC) mixtures, LC assembly and thermal design and packaging. The FORK project consortium gathers European competence centers, each having expertise in one or more of the technology fields mentioned above. This consortium has drawn an ambitious though realistic workplan in which the targeted project objectives can be reached successfully. The European display and semiconductor industry is under strong international competition, mainly from greater China and other Asian countries. A possible way to escape from the cost pressure is to differentiate by specialties and added-value features generated by innovation, IP and know-how. These values will be generated with the objectives of the FORK project.",Development of 4k compatible LCOS microdisplay for D-cinema and simulation applications,FP6,31 July 2008,31 January 2006,3000000.0 FORMAMP,SP Technical Research Institute of Sweden * SP Sveriges Tekniska Forskningsinstitut AB,health,"Resistance to traditional antibiotics is a rapidly increasing problem that in a few years could make infections impossible to treat and bring the state of medical care back to the pre-antibiotic era from the beginning of the last century. Antimicrobial peptides (AMPs) have a huge potential as new therapeutics against infectious diseases as they are less prone to induce resistance due to their fast and non-specific mechanism of action. The aim of FORMAMP is to explore a number of innovative formulation and delivery strategies based on nanotechnology in order to improve the efficiency and stability of AMPs in clinical development. Functional delivery systems that can be applied directly on the infected site will be developed for treatment of infections in skin and burn wounds, as well as lung infections caused by Methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Mycobacterium tuberculosis (MTB). Formulation and delivery strategies to prevent and treat biofilm formation related to these conditions will be developed. Different nanoformulation platforms, particularly promising for peptide delivery, controlled release strategies and technologies against proteolytic degradation of peptides will be evaluated in the project. These include lipid-based systems such as lipidic nanocapsules, polymer-based structures such as dendrimers and microgels as well as nanostructured mesoporous silica. The possibility to formulate the nanostructured materials into efficient drug delivery systems such as a topical spray or gel and pulmonary aerosol will be evaluated. The effect of nanoformulated AMPs will be evaluated with state-of-the art in vitro models and in vivo models. The results of this interdisciplinary project will generate efficient treatment strategies combatting one of the largest threats to our health care system today, reducing healthcare costs and expand the growth of European enterprises within the field of pharmaceutics and nanomaterials.",Innovative Nanoformulation of Antimicrobial Peptides to Treat Bacterial Infectious Diseases,FP7,30 November 2017,01 December 2013,7945494.0 FP7 TNT FUNCTION,University of Bergen * Universitetet i Bergen,health,"Tunneling nanotubes (TNTs), recently discovered thin membrane channels connecting distant cells, represent the underlying structure of a previously unrecognized type of cell-to-cell communication. To date, a growing number of cell types have been found to use TNTs for the intercellular exchange of diverse cargoes ranging from cytoplasmic signalling molecules such as calcium ions to small vesicles of endocytic origin. During the past year, pathogens such as the human immunodeficiency virus and prions were also found to spread TNT-dependently between cells. Given the emerging wide range of implications of TNTs in the field of biomedical research, it is important to first learn the basic principles and mechanisms of TNT-dependent cell-to-cell interactions. I therefore propose to focus on three major questions: First, I will characterize the type of endocytic vesicles transiting through TNTs using flow cytometry and quantitative live cell imaging to monitor the transfer of endosomal markers (Rab GTPases) through TNTs. Secondly, using the same methodological approach, I will analyze which myosin motor(s) is (are) involved in the active transport of vesicles through TNTs. Third, by employing a proteomic screen assay, I aim at characterizing the entire set of proteins/signalling molecules transferred through TNTs.","Towards the mechanism and function of tunneling nanotube (TNT)-dependent, intercellular exchange of cargo",FP7,31 March 2012,01 April 2010,204568.0 FQT,Imperial College London,photonics,"Mission Statement: To deliver an internationally competitive student cohort who will be equipped to be the research and industry leaders of the future through interdisciplinary training at the frontiers of Quantum Technology. The ability to engineer materials at the atomic level has led to the enormously active field of nanotechnology: the analysis, design and fabrication of devices that operate at the leading-edge of optical and electronic technology. This technology has inevitably revealed the true quantum nature of the microscopic world, where particles and waves co-exist and interact in novel exciting ways. The study of quantum information and quantum technology has now been around for some time, and this is the ideal opportunity for the fundamental science to work with industrial researchers to make advancements which the market wants, rather than those which serve only the scientists' curiosities. Along this line, we have identified two strands of research themes, namely, the generation of extreme light sources and the study of light-matter interactions, with a view to the development of quantum technology. Imperial College has a large team of researchers (17 members of academic staff and 50 postdoctoral fellows: research grants over £30m) working at the leading edge of quantum sciences encompassing surface plasmonics, cold atoms, attosecond lasers and quantum theory. Coupled with newly refurbished postgraduate lecture facilities, a brand new state-of-the-art workshop, and new offices for the quantum theory group this makes Imperial ideal for student training. The associated partners include top academic institutes, government labs and private companies which will be actively involved in student recruitment, research and training. Imperial has been known for attracting world's best students and with the current IDP we will be able to train those students to become leading scientists with the creative ideas to answer the beneficiaries' needs.",Frontiers in Quantum Technology,FP7,31 August 2017,01 September 2013,3816691.0 FRACFIX,Nor-Tek Teknologisenter AS,health,"Internal fixation components are widely used in fracture surgery. The medical implant industry is a part of the medical device market generates about €2.4 Bn in Europe and €1.5 Bn in the USA in 2008 and has an estimated annual growth of 10% per year, largely attributed to the aging population in the developed countries. Internal fixation devices market is an estimated €980 Mn in EU25. The total cost of treatment is much higher due the cost of removing the fixation devices, an estimated €3.4 Bn per year in EU25. The idea of FracFix is to develop a fixation system that can be painlessly and easily removed at exact desired moment without surgery and general anaesthesia. During the project a fixator in nano-polymer composite with melting temperature below 50ºC and solid at 41.5 ºC, will be developed to use as the construction material for standard internal fixation parts, as well as an external unit able to melt the material so it can be removed through a 10mm hole in the skin. Internal fixation hardware removal results in high costs for the hospitals and risks and discomfort for the patrient. Removing the need for secondary surgery gives saving of medical personnel's time and average cost of use of recovery room after general anaesthesia is €400 per patient, bringing the total bill of surgery to €1,250 per surgery. The data for combined surgery and trauma suggests that 18.1% of all procedures in the group result in major complications, and 13.5% result in minor complications, adding to morbidity costs to society. At 140,000 internal fixation removal procedures per year in EU and 90,000 in the USA, the estimated yearly death toll due to hardware removal only is 3,192 patients per year in EU25.",Elimination of secondary surgery for removal of internal fixations of fractured bones,FP7,31 July 2011,01 November 2008,1127808.0 FREECATS,Norwegian University of Science and Technology * Norges Teknisk-Naturvitenskapelige Universitet (NTNU),transport,"This project is primarily aimed at generating new fundamental knowledge and fostering new prospects and frontiers in the field of catalysis for the sustainable production of chemicals and commodities. Rethinking important metal-based catalytic processes in the light of new tailored metal-free catalytic architectures designed and fabricated starting from appropriate nanoscale building blocks, is the fundamental target of this research project. Major efforts have been made in the last decades aimed at addressing catalytic approaches, as much as possible, denoted by sustainable and environmentally friendly features. A large fraction of products made today are produced with traditional methods developed several decades ago. In order to keep the European process industry competitive worldwide, the development of technologically advanced processes represent a fundamental prerequisite. The FREECATS proposal deals with the development of new metal-free catalysts, either in the form of bulk nanomaterials or in hierarchically organized structures both capable to replace traditional noble metal-based catalysts in catalytic transformations of strategic importance. The new metal-free catalytic materials will be applied to specific processes traditionally carried out by means of precious metal-based materials. The application of the new materials will eliminate the use for platinum group metals and rare earth elements such as ceria used in fuel cell technology (automotive applications and others), production of light olefins, and in wastewater and water purification. Replacing platinum group metal alternatives in these three emerging technologies will lead to a significant reduction in demand of platinum group metals in Europe, at least mounting to the current automotive platinum group metal demand, estimated to be in the order of 50-100 tons per year.",Doped carbon nanostructures as metal-free catalysts,FP7,03 July 2017,04 January 2012,3955619.0 FTHISCOD,IFOM the FIRC Institute of Molecular Oncology * Istituto FIRC di Oncologia Molecolare (IFOM),health,"Using nanoflow LC coupled on-line to a novel FTICR mass spectrometer we want to describe the complexity of histone modifications and define co-occurring modifications. We want to then investigate the biological role of these simultaneous present modifications by using synthetic peptides for pull-down experiments and stable isotope labeling for quantitation and effective back-ground subtraction to identify specifically binding proteins. We will focus after the implementation and test of the methods in a global scenario on metH3K9 which is central for gene silencing. In this way we intend to find out if other modifications are involved in fine-tuning and regulating gene silencing. This is central for our understanding of the histone code and epigenetics and may lead to a better understanding of cancer. M. Salek will move for this project to J. Rappsilber's group in Milan. He brings with him the experience of a PhD in mass spectrometric analysis of protein modifications and method development. He will be trained in LC-MS and FTICR MS and expand his experimental repertoire by peptide synthesis and pull down experiments. He will expand his analytical training into medical direction joining a campus that hosts two large cancer research institutes and is affiliated with two major cancer hospitals in Milan. The increased expertise in technology, in medical applications, and in administration will put him after this fellowship in an excellent position to respond to the European urge for proteomics groups. J. Rappsilber's group will gain with M. Salek competence essential for the proposed project and for the success of the group. M. Salek's connection to his former lab will result in transfer of expertise in the analysis of protein modification and long term access to instrumentation available there. M. Salek will go for a short stay to M. Mann's lab, one of the leading proteomics centers worldwide, and allow tightening the link to this lab while getting himself networked.",investigation of the histone code by high-resolution FTICR mass spectrometry and molecular biology,FP6,30 September 2006,01 October 2005,142612.16 FTMEMS,Vereniging voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek en Patientenzorg * Association for Christian Higher Education Scientific Research and Patient Care,health,"Fiber-top sensors (D. Iannuzzi et al., patent application number PCT/NL2005/000816) are a new generation of miniaturized devices obtained by carving tiny movable structures directly on the cleaved edge of an optical fiber. The light coupled into the fiber allows measurements of the position of the micromechanical parts with sub-nanometer accuracy. The monolithic structure of the device, the absence of electronic contacts on the sensing head, and the simplicity of the working principle offer unprecedented opportunities for the development of scientific instruments for applications in and outside research laboratories. For example, a fiber-top scanning probe microscope (also in the form of a PenFM, where a fiber-top atomic force microscope would be incorporated in a pen-like stylus) could be routinely used in harsh environments and could be easily handled by untrained personnel or through remote control systems -a fascinating perspective for utilization, among others, in surgery rooms and space missions. Similarly, the development of fiber-top biochemical sensors could be exploited for the implementation of portable equipment for in vivo and Point of Care medical testing. Fiber-top sensors could be used for the measurement of parameters of medical relevance in interstitial fluid or in blood -an interesting opportunity for intensive care monitoring and early detection of life-threatening diseases. This scenario calls for a coordinated research program dedicated to this novel generation of devices. It is my intention to forge a laboratory gravitating around fiber-top technology. My group will have the opportunity to pioneer this research area and to become the reference point in the field, on the forefront of an emerging subject that might represent a major breakthrough in the future development of micromachined sensors.",Fiber-top micromachined devices: ideas on the tip of a fiber,FP7,31 May 2013,01 June 2008,1799915.0 FULLSPECTRUM,Technical University of Madrid * Universidad Politécnica de Madrid,energy,"The project pursues a better exploitation of the FULL solar SPECTRUM (as requested in the Work Programme) by further developing concepts already scientifically proven but not yet developed and by trying to prove new ones in the search of a breakthrough for the PV technology. More specific objectives are the development of: a) III-V multijunction cells (MJC), b) Solar Thermo-photovoltaic (TPV) converters, c) Intermediate band (IB) materials and cells (IBC), d) Molecular based concepts (MBC) for full PV utilisation of the solar spectrum and e) Manufacturing Technologies for novel concepts including assembling. MJC technology towards 40 % efficiency will be developed using lower cost substrates and high light concentration (up or above 1000 suns). TPV is a concept of high theoretical efficiency limit because the whole energy of all the photons is used in the heating process and because the non-used photons can be feed back to the emitter, therefore assisting in keeping it hot. Small prototypes with sun/gas heated emitters will be developed. In the IBC approach sub-bandgap photons are exploited by means of an IB. IB materials will be sought by direct synthesis suggested by material band calculations and using nanotechnology in quantum dot IBCs. In the development of the MBC, topics like the development of two-photon dye cells and the development of a static global (direct and diffuse) light concentrator by means of luminescent multicolour dyes and QDs, with the radiation confined by photonic crystals, will be particularly addressed. Manufacturing technologies include using optoelectronic assembling techniques and coupling of light to cells with new-optics miniconcentrators.",A new PV wave making more efficient use of the solar spectrum (FULLSPECTRUM),FP6,31 October 2008,01 November 2003,8339993.0 FUMASSY,Aalto University * Aalto-yliopisto,health,"I seek the Marie Curie Career Integration Grant grant to support my effort to establish a new independent research group lead by me in the Department of Chemistry at Aalto University School of Chemical Technology, Finland. I am a young Finnish researcher, who after finishing her doctoral studies in December 2004, moved to United States for her post-doctoral research and ever since has been successfully pursuing a research career in top US research environments currently in Yale University and before that in Princeton University. Research in the Sammalkorpi group will apply computational and theoretical methods toward engineering drug delivery, biosensing, and separation membrane systems based on surfactant self-assembly. Amphiphilic surfactant aggregates and their capacity to change form, structure, and dynamics lie at the heart of many natural and synthetic processes. For example, lipid and detergent micelles, vesicles, and membranes play a key role both in cellular and synthetic molecular transport and regulation [Schmidt, Nature (2002); Hubbell, Science (2003)]. The same molecules form tunable coatings, lubrication layers, and novel nanoscale functional soft materials [Min et al., Nature Materials (2008); Hillmyer, Science (2007); van Hest, Nature (2009)]. My initial research will focus on two areas with common themes of molecular self-assembly and the key influence of aggregation on system dynamics: 1) small interfering RNA (siRNA) delivery via micellar and vesicular carriers and 2) novel functional materials based on functionalized carbon nanotubes in amphiphilic surfactant aggregates. I apply the Marie Curie Career Integration funds for 4 years to improve the chances of success I have on establishing this ambitious new line of research in the Department of Chemistry at Aalto University.",Functional materials through surfactant self-assembly,FP7,31 December 2015,01 January 2012,100000.0 FUNC,Philips Innovative Technology Solutions NV,information and communications technology,"The Si-based Complimentary Metal-Oxide-Semiconductor Field-Effect Transistor technologies (CMOS FET) are the foundation of the electronic industry. However, the continued scaling of the MOSFET device below the 45nm technology node (sub-20nm gate lengths, expected in production after 2007) will require fundamental changes in the CMOS processing and the introduction of new materials. It is notable however, that so far all the efforts of the industry to replace Si-SiO2 system with Si-High-k one have failed, pointing towards the fundamental issues of such replacement. In addition, the roadmap requires an increase in device performance associated with extra improvement in mobility/transconductance for sub-25nm MOSFETs. Such performance increase should be as large as 100% for the smallest generations and can be achieved with alternative channel materials (e.g., Ge and most III-IV semiconductor compounds have inherent electrical advantages over Si, such as a higher electron mobility and/or breakdown voltage). There is a strong need exists to examine thoroughly the key parameters that will allow the introduction of such new materials in future CMOS devices. It is the purpose of this project to study in detail the fundamental possibilities for CMOS scaling provided by novel materials. The work will be separated into the following sub-topics:- Modeling of Semiconductor-Dielectric-Gate electrode interfaces in future FET devices- Process and Device modeling of Alternative to Si channel materials compatible with Si CMOS processing The fundamental understanding achieved on the basis of these studies will be used to demonstrate MOSFET devices in sub-25nm gate-length regime suitable for future CMOS integration activities.",Fundamental Understanding of Novel materials integration in future CMOS.,FP6,31 August 2008,01 September 2004,444774.0 FUNCA,University of Bristol,information and communications technology,"We outline an ambitious 5 year interdisplinary research programme that introduces a fundamentally new platform to the fabrication of nanoelectronic and liquid crystal devices, current areas of intense scientific and technological interest. The new approach involves the use of block copolymer micelles and block comicelles prepared by Crystallization-Driven Living Polymerization (CDLP) processes. This novel method allows unprecedented access to well-defined micelle architectures (with size control, narrow size distribution, and access to segmented structures that possess heterojunctions). Crosslinking will also be used to optimize micelle mechanical properties where necessary. The new platform offers very promising advantages over competitive methods for realising nanomaterials these include ambient temperature synthesis and solution processing, easy control of dimensions and aspect ratio, electronic properties, and semiconductor/semiconductor or semiconductor/dielectric junction fabrication. In addition, the use of hydrophilic coronas should, in principle, allow the self-assembly processes and subsequent manipulations to be performed in water.",Functional Nanomaterials via Controlled Block Copolymer Assembly,FP7,03 July 2018,04 January 2010,1658544.0 FUNCCAHNHILLIARDPNP,Technion Israel Institute of Technology,energy,"The functionalized Cahn-Hilliard energy is a phase-field characterization of an interfacial energy used to describe dynamics of amphiphilic network formation. We have successfully applied the functionalized Cahn-Hilliard energy to model the morphology of water nano-pore networks in ionomer membranes. The resulting morphology model was validated with experimental scattering data of Nafion, an ionomer membrane which is a critical component in fuel cells. It is natural to use, as a basis, the successful morphology model to study the effect of morphology on membrane performance, e.g., conductivity. The functionalized Cahn-Hilliard energy offers, however, only a phenomenological treatment of the electrostatic forces between the polymer and the water. Such a treatment effectively blocks important extensions of the model. The main goal of this proposal is the development, analysis, and simulation of continuum models which characterize amphiphilic network formation coupled to ion transport. Attaining this goal requires redeveloping key components of the functionalized Cahn-Hilliard model while operating on a wide range of scales, e.g., from the non-uniform water structure in a pore at the nanoscale to membrane conductivity at the macroscale. A key application of this proposal is to study conductivity and selectivity of ionomer membranes and their dependence upon morphology and ionic concentrations. The project is of clear interdisciplinary nature, merging problems, ideas and tools from Mathematics, material science, solution chemistry and soft matter physics. The design and performance of novel clean energy devices such as fuel cells, flow batteries, or organic solar cells critically depends on the optimized coupling between material nanostructure, electrostatics, charge transport and nanoflows. Any progress in the directions proposed above will open the way to robust phase-field models which can incorporate and couple these four effects.",Variational models of network formation and ion transport: applications to polyelectrolyte membranes,FP7,31 August 2017,01 September 2013,100000.0 FUNCMOLQIP,University of Barcelona * Universitat de Barcelona,information and communications technology,"The future of Nanotechnology depends inevitably on the creation of molecular devices capable of performing crucial functions. We propose new strategies for the design and synthesis of molecular functional materials based on coordination chemistry, as well as the study of their physico-chemical properties in order to evaluate their relevance in the context of molecular spintronics and electronics. The main rationale underlying these strategies stems from the conviction that the unlimited potential of coordination compounds may be greatly exploited if the processes of self assembly leading to these systems are controlled and manipulated through the careful design of the ligands that will shape their structure and properties. We have designed the synthesis of new families of multinucleating ligands intended to form polynuclear coordination molecules with predetermined structures. Preliminary analysis of their performance has served to identify entries into novel categories of Single Molecule Magnets, SMMs, and Molecular Cluster Pairs, MCPs. The latter are stable molecules that exhibit two quasi independent metallic clusters, which fulfil many of the requirements necessary to act as 2qbit quantum gates for processors in quantum computing. We propose a full synthetic programme aimed at exploiting and expanding this promising avenue toward the fabrication of molecular systems that will be exploited in the context of Quantum Information Processing, QIP. In particular, we have identified from our previous work three classes of MCPs with promising features towards that end. We aim at exploiting the tools that we have created and develop new synthetic resources for the synthesis of robust molecules with the ability to act as 2qbits in QIP based on magnetic nanoclusters.",Design and Preparation of Functional Molecules for Quantum Computing and Information Processing,FP7,06 June 2018,07 January 2011,1500000.0 FUNDMS,Institute of Physics Polish Academy of Sciences * Instytut Fizyki Polskiej Akademii Nauk (IF PAN),information and communications technology,"Low-temperature studies of transition metal doped III-V and II-VI compounds carried out over the last decade have demonstrated the unprecedented opportunity offered by these systems for exploring physical phenomena and device concepts in previously unavailable combinations of quantum structures and ferromagnetism in semiconductors. The work proposed here aims at combining and at advancing epitaxial methods, spatially-resolved nano-characterisation tools, and theoretical modelling in order to understand the intricate interplay between carrier localisation, magnetism, and magnetic ion distribution in DMS, and to develop functional DMS structures. To accomplish these goals we will take advantage of two recent breakthroughs in materials engineering. First, the attainment of high-k oxides makes now possible to generate interfacial hole densities up to 10^21 cm-3. We will exploit gated thin layers of DMS phosphides, nitrides, and oxides, in which hole delocalization and thus high temperature ferromagnetism is to be expected under gate bias. Furthermore we will systematically investigate how the Curie temperature of (Ga,Mn)As can be risen above 180 K. Second, the progress in nanoscale chemical analysis has allowed demonstrating that high temperature ferromagnetism of semiconductors results from nanoscale crystallographic or chemical phase separations into regions containing a large concentration of the magnetic constituent. We will elaborate experimentally and theoretically epitaxy and co-doping protocols for controlling the self-organised growth of magnetic nanostructures, utilizing broadly synchrotron radiation and nanoscopic characterisation tools. The established methods will allow us to obtain on demand either magnetic nano-dots or magnetic nano-columns embedded in a semiconductor host, for which we predict, and will demonstrate, ground-breaking functionalities. We will also assess reports on the possibility of high-temperature ferromagnetism without magnetic ions.",Functionalisation of Diluted Magnetic Semiconductors,FP7,12 July 2015,01 January 2009,2440000.0 FUNDNAMAT,University of Granada * Universidad de Granada,health,"This research project will focus on the development of conducting molecular architectures using self-assembly processes between specific DNA sequences and metal ions-derivatives. The concept is to use the interaction of specific metal ions towards precise DNA nucleobases. Novel synthetic metal complexes will be prepared carrying specific functional units capable of directing the formation of conducting polymers. These metal complexes will be organized at the nanoscale by interaction with particular DNA base-sequences through self-assembly processes. The project will also involve the preparation of complex DNA-based nanomaterial structures through a novel route which extends upon the well-established DNA origami concept using the unique properties of metal ions and their specificity to form metal-mediated DNA duplexes. The self-assembly properties of DNA and specific metal-ions will be explored for the construction of complex nanoscale architectures. Importantly, the original methodology proposed will be also employed for the incorporation of further functionality into DNA-based nanomaterials, since the properties of the metal-complexes can be tailored with different functional groups. Established synthetic methodologies will used for the synthesis of the metal-precursor compounds and these will be characterised using standard techniques to set up structural details, e.g. NMR, elemental analysis, ionized electrospray mass spectroscopy LC(IES-MS), spectroscopic (FTIR, UV-vis). The formation of conducting polymer nanomaterial will involve chemical oxidation or metal-coordination of the organized units along the DNA molecules. The resulting materials will be characterised using a range of spectroscopy techniques (FTIR, CD, UV-vis) as well as state-of-the-art scanning probe microscopy (AFM, EFM, STM). Finally, the conducting properties of the materials will be examined using a combination of 2-electrode devices and scanning probe methods.",Functional DNA-based nanomaterials using metal-mediated self-assembly processes,FP7,09 July 2014,10 July 2011,45000.0 FUNFLUOS,Humboldt University of Berlin * Humboldt-Universität zu Berlin,environment,"The proposed work targets a specific branch of material science, solid metal fluorides with functionalised surfaces. It is both fundamental and applied in nature and comprises innovative synthesis, highly sophisticated characterisation, simulation/modelling and applications. The objective is to explore the upper limits of surface area, porosity, acidity and thermal stability achievable for these materials. Highly innovative synthetic approaches, including a recently developed non-aqueous route to very high surface area aluminium(lll) fluoride, will be used to obtain fluorides and fluorinated oxides of different metals, having characteristics far exceeding those exhibited by currently known forms. Specific synthetic goals are to obtain solid fluorides with surface areas ten times higher than presently known and with extremely high Lewis acidity; particular attention will be given to aluminium-containing materials. Synthesis will be combined with broad physicochemical characterisation, including highly advanced in situ methodologies supported by predictive simulation/modelling techniques, all geared to understand the underlying processes at molecular- and nano-levels. As a result, processes to control, tailor and modify target characteristics of the relevant materials for specific applications will be established. Mid-term innovation activities will be performed by the SME on two reactions of current technological importance. Replacement of widely used homogeneous Lewis acids, such as antimony(V) fluoride, by environmentally more acceptable, newly developed solid acids is a longer term technological goal, having high economic and environmental impacts. The use of fluoride materials in areas not directly connected with fluorine chemistry, for example in industrial acid catalysed processes employing Friedel-Crafts alkylation and acylation, is the third possible application.",Functionalised metal fluorides,FP6,31 January 2008,01 September 2004,2399900.0 FUNICIS,University of Warwick,information and communications technology,"This proposal presents unique approaches for the functional characterization of charged interfaces and interfacial phenomena at the nanoscale, through the implementation of an innovative and quantitative ion flux imaging technique. The scientific scope of the project involves the development of a frontier high resolution electrochemical imaging technique, based on scanning ion conductance microscopy that will be capable of probing the nanoscale structure and charge heterogeneity at almost any kind of interface. This represents a major fundamental science aim, that will also open new horizons for the exploration of nanomaterials, including novel electrode materials (graphene and graphene oxide, carbon nanotubes), as well as for imaging self-assembled nanostructures of metallic nanoparticles (NPs). The methodology will allow us to determine the microscopic physicochemical characteristics of individual NPs and their assemblies at soft interfaces and reveal the reactivity of electrocatalytic substrates for fuel cell reactions. We will be able to identify active sites on catalysts and relate these directly to structure - of huge benefit for the understanding and rational design of future functional materials. The research proposal is highly interdisciplinary, and there is a natural fit between the Fellow’s profile and activities at the Host Warwick group. The proposal draws on Fellow’s strong multidisciplinary background in chemistry, mathematical modelling and microtechnology, especially in understanding charged interfaces and nanoscale ion flows, that will be married with the world-leading research on innovative imaging techniques being developed at Warwick. With considerable support and world-leading expertise from the Host group and its collaborators, this project will provide the applicant, Dr. Dmitry Momotenko, with an outstanding opportunity to develop personally and professionally, by pioneering a new area of research in a new geographic location.",Functional Ion Conductance and Sensing,FP7,05 July 2018,06 January 2014,221606.4 FUNKIFIBRE,Elastopoli Oy,environment,"Cereal waste biomass is a potential source of valuable compounds such as bio-based fibres that can be used in new potential applications. This is the case of the microfibrillated cellulose (MFC) which is a novel type of cellulose with nano-scale dimensions and very interesting properties for the development of composite materials due to its high strength and stiffness combined with its low weight, biodegradability and renewability.",CEREAL WASTE VALORISATION THROUGH DEVELOPMENT OF FUNCTIONAL KEY FIBRES TO INNOVATE IN FIBRE PACKAGING MATERIALS,FP7,08 July 2017,09 January 2013,0.0 FUNMANIA,Tel Aviv University,health,"Recent advances in nano technologies provide an exciting new tool-box best suited for stimulating and monitoring neurons at a very high accuracy and with improved bio-compatibility. In this project we propose the development of an innovative nano-material based platform to interface with neurons in-vivo, with unprecedented resolution. In particular we aim to form the building blocks for future sight restoration devices. By doing so we will address one of the most challenging and important applications in the realm of in-vivo neuronal stimulation: high-acuity artificial retina. Existing technologies in the field of artificial retinas offer only very limited acuity and a radically new approach is needed to make the needed leap to achieve high-resolution stimulation. In this project we propose the development of flexible, electrically conducting, optically addressable and vertically aligned carbon nanotube based electrodes as a novel platform for targeting neurons at high fidelity. The morphology and density of the aligned tubes will mimic that of the retina photo-receptors to achieve record-high resolution. The most challenging element of the project is the transduction from an optical signal to electrical activations at high resolution placing this effort at the forefront of nano-science and nano-technology research. To deal with this difficult challenge, vertically aligned carbon nanotubes will be conjugated with additional engineered materials, such as conducting polymers and quantum dots to build a supreme platform allowing unprecedented resolution and bio-compatibility. Ultimately, in this project we will focus on devising materials and processes that will become the building blocks of future devices so high density retinal implants and consequent sight restoration will become a reality in the conceivable future.",Functional nano Materials for Neuronal Interfacing Applications,FP7,30 September 2017,01 October 2012,1499560.0 FUNMAT,Linköping University * Linköpings Universitet,manufacturing,"I aim to achieve a fundamental understanding of the atomistic kinetic pathways responsible for nanostructure formation and to explore the concept of self-organization by thermodynamic segregation in functional ceramics. Model systems are advanced ceramic thin films, which will be studied under two defining cases: 1) deposition of supersaturated solid solutions or nanocomposites by magnetron sputtering (epitaxy) and arc evaporation. 2) post-deposition annealing (ageing) of as-synthesized material. Thin film ceramics are terra incognita for compositions in the miscibility gap. The field is exciting since both surface and in-depth decomposition can take place in the alloys. The methodology is based on combined growth experiments, characterization, and ab initio calculations to identify and describe systems with a large miscibility gap. A hot topic is to elucidate the bonding nature of the cubic-SiNx interfacial phase, discovered by us in TiN/Si3N4 with impact for superhard nanocomposites. I have also pioneered studies of self-organization by spinodal decomposition in TiAlN alloy films (age hardening). Here, the details of metastable c-AlN nm domain formation are unknown and the systems HfAlN and ZrAlN are predicted to be even more promising. Other model systems are III-nitrides (band gap engineering), semiconductor/insulator oxides (interface conductivity) and carbides (tribology). The proposed research is exploratory and has the potential of explaining outstanding phenomena (Gibbs-Thomson effect, strain, and spinodal decomposition) as well as discovering new phases, for which my group has a track-record, backed-up by state-of-the-art in situ techniques. One can envision a new class of super-hard all-crystalline ceramic nanocomposites with relevance for a large number of research areas where elevated temperature is of concern, significant in impact for areas as diverse as microelectronics and cutting tools as well as mechanical and optical components.",Self-Organized Nanostructuring in Functional Thin Film Materials,FP7,11 June 2015,12 January 2008,2292000.0 FUNMOL,University College Cork,manufacturing,"Recent developments in the design and synthesis of nanoscale building blocks as active elements in opto- or bio-electronic devices with tailored electronic functionality have the potential to open up new horizons in nanoscience and also revolutionise multi-billion dollar markets across multiple technology sectors including healthcare, printable electronics, and security. Ligand-stabilised inorganic nanocrystals (~2-30 nm core diameters) and functional organic molecules are attractive building blocks due to their size dependent opto-electronic properties, the availability of low-cost synthesis processes and the potential for formation of ordered structures via (bio) molecular recognition and self-assembly. Harnessing the complementary properties of both nanocrystals and functional molecules thus represents a unique opportunity for generation of new knowledge and development of new classes of high knowledge-content materials with specific functionality tailored for key applications, e.g., printable electronics, biosensing or energy conversion in the medium term, and radically new information and signal processing paradigms in the long term. Self-assembly and self-organisation processes offer the potential to achieve dimensional control of novel multifunctional materials at length scales not accessible to conventional “top-down†technologies based on lithography. It is critical for European industry to develop new knowledge and low-cost, scaleable processes for assembly and electrical interfacing of these multifunctional materials with conventional contact electrodes in order to produce into tailored devices and products, in particular on low-cost substrates. The FUNMOL consortium will deliver substantial innovation to European industry via development of cost-effective, scaleable processes for directed assembly of high-knowledge content nanocrystal-molecule materials into electrically-interfaced devices at silicon oxide, glass and plastic substrates.",Multi-scale Formation of Functional Nanocrystal-Molecule Assemblies and Architectures,FP7,03 July 2014,10 January 2008,3464710.0 FUNMOLS,Durham University,information and communications technology,"The FUNMOLS network will tackle major challenges in the field of molecular electronics. Ten internationally-leading European research groups from five different countries [including one of Europe’s leading industrial electronics-research groups (IBM Zurich)] have joined forces as full participants, combining expertise in synthetic chemistry, nanoscale physics and device engineering, surface electrochemistry and electronic structure calculations. Our highly-integrated approach involves a convergence of experiments – including syntheses – and theory in electron transport through single molecules, which will represent a major step towards the realisation of future scalable molecular electronics technologies and processes. In the longer term, the insights gained will contribute to the fabrication of functional nanoscopic architectures and their integration into a higher hierarchical level. System parameters like electric field, light, temperature or chemical reactivity are envisaged as possible triggers of future nanoelectronic devices. This European consortium is committed to promote breakthroughs at the frontier of science. The training dimension of the FUNMOLS network is reflected in the high priority we will give to a series of actions specifically aimed at early stage researchers (ESRs). These include: education and knowledge dissemination through the organisation of Workshops, Tutorial Courses, Annual Network Meetings, Training Schools, International Conferences and Mobility Programmes. The network as a whole builds on several fruitful collaborations between the PIs and seeks to close an existing educational gap in the European Research Arena. The development of complementary skills (presentation, management, technology transfer, IP protection) will be implemented actively throughout the lifetime of the project. A constant interaction beyond those involved primarily in research will provide the wider scientific community with information on our new technology.",Fundamentals of Molecular Electronic Assemblies,FP7,09 June 2014,10 January 2008,2799062.0 FUNPROB,Durham University,information and communications technology,"Scanning probe microscopy (SPM) is an established technique for the characterisation of materials and structures at the nanoscale and is increasingly bridging traditional disciplines including the biosciences. As such, it is of fundamental and practical interest across the sciences and industry. The geometry of the tip is the critical factor which determines the resolution of an SPM sensor. In an attempt to achieve ultra high spatial resolution, carbon nanotubes have been widely investigated and shown some promise. However, it is extremely difficult to control the properties of these tubes, especially the electrical behaviour and growth geometry. Equally, their manipulation is a daunting task. We propose to use III-V semiconductor nanowires as functioning sensors at the apex of scanning probes. These structures can be directly grown on the substrates or SPM cantilevers with controllable properties at the nanometre scale. Using these nanowires offers excellent new avenues for the integration of established semiconducting devices onto the tip of a scanning probe. This will improve the sensitivity and functionality of scanning probe methods. An example of potential applications for such a novel probe is the detection of virus based on their electrical response which can be coupled to that of nanowires under appropriate conditions. Within the framework of this project, we will combine the complementary expertise of various internationally leading institutions for the creation of integrated individual semiconductor nanowire SPM probes exhibiting enhanced functionalities.",Functional semiconductor nanowire probes,FP7,06 June 2017,07 January 2011,374300.0 FUNSTAR CAPSULE,Imperial College London,health,"Chemotherapy has been the leading therapy for treating cancer to date. However, its applicability has been limited by high price and low effectiveness of current chemotherapeutics. The limitations could be overcome by understanding the therapeutic mechanism of drug candidates allowing the best compounds to undergo expensive and time-consuming clinical trials. Although cell-based profiling methods greatly streamline the drug screening process, the current methods are restricted by multistep processing, time consuming and low-throughput analysis, and the requirement of large number of cells. The FunStar Capsule proposal aims to develop a simple and powerful supramolecular nanocapsule platform for phenotyping drug-treated cell surfaces. This radically new concept in drug screening will generate characteristic spectroscopic patterns for different drug-treated cell surfaces that will be used to predict the mechanisms of new therapeutic molecules. The proposal introduces for the first time live cell Raman micro-spectroscopy for creating the patterns using a unique nanocapsule that is fabricated through the hierarchical assembly of functionalized gold nanoparticles (AuNPs) and nanostars. The AuNPs will recognize the cell membrane while the nanostars will create characteristic Raman signatures through a surface enhanced Raman scattering mechanism. The robust and biocompatible platform would provide several advantages: (i) rapid (minutes) analysis, (ii) less number of cells required (possibly single cell), (iii) label-free method, (iv) highly sensitive and non-destructive technique, (v) both efficacy and mechanism of a molecule can be determined from a single well of a microplate. This multidisciplinary proposal combines concepts of materials chemistry and life sciences to design a cell phenotyping platform with applications beyond drug screening such as cancer detection and cell sorting, making this approach attractive for industrial sectors of pharmacology and diagnostics.",Functional Nanostar Encapsulated Nanocapsule for Cell-based High-throughput Drug Screening,FP7,29 February 2016,01 March 2014,231283.0 FUNSURF,University of Leuven * Katholieke Universiteit Leuven,manufacturing,"FUNSURF is an interdisciplinary research project which lies at a natural meeting point between chemistry, physics, materials science and nanotechnology. The project will enable a bright young scientist with an impressive track record to gain a high level of cross-disciplinary training in diverse new aspects of supramolecular self-assembly and reactivity, scanning probe microscopy, photochemistry and optical spectroscopy. The training-through-research basis of FUNSURF focuses on the design, synthesis and characterisation of functional supramolecular networks on surfaces. Many of the structures produced by supramolecular self-assembly display high levels of spatial order making it an ideal method for producing the next generation of functional nanostructured devices. In addition to producing novel, high impact science this project gives the researcher the opportunity to work in an internationally recognised group at a host organisation which provides excellent postgraduate training in both scientific and complementary professional skills. FUNSURF will produce molecular architectures which can be activated by external stimuli to perform specific functions. These include, switching on or off adsorption sites in a network via optically induced changes in molecular configuration and initiating localised chemical reactions. Alongside this the development of Tip-Enhanced Raman Spectroscopy (TERS) will provide a chemically specific characterisation tool with nanoscale resolution. The researcher’s background makes him perfectly suited to achieving these objectives, while the experience of new research disciplines will allow him to cultivate the broad range of skills key to driving new scientific developments in this area. This combination of training and interdisciplinary experience is essential in assuring the researcher attains an independent position at the forefront of future research efforts.",Functional Supramolecular Networks on Surfaces,FP7,08 July 2014,09 January 2010,159100.0 FUTURA,Daimler AG,transport,"The pressure caused from the Asiatic and American competitors, in terms of volume manufacturing, forces the European automotive industry to continuously promote the development of cost efficient-innovative vehicles, with high-added customer value, increased personalization capabilities and environmental sustainability. Main objective of the FUTURA IP is to develop vehicle production setups of the future, by integrating cost validated, up to proof-of-concept level, production technologies of MFMs, reducing at the same time manufacturing costs up to 25% and ensuring key production attributes: TTM efficiency, flexibility, robustness and environmental sustainability. A straight forward, objective-driven research approach, will be utilised, based on the scheme: Specifications?Technology Development?Technology Integration?Technology Validation?Technology Exploitation. The FUTURA Factory will result as the outcome of integrating MFMs and related processing/production techniques in production setups for manufacturing body modules and a flexible vehicle chassis structure consisting of 4 major segments. FUTURA IP will address the state of the art forming and joining processing concepts and requirements of MFMs, including sandwich materials, nano-materials, HSSs, etc. Furthermore, novel vehicle concepts that facilitate MFMs implementation will be addressed, including modular, scalable, hybrid body and chassis structures. The efficient operation of the production setups and their interrelation will be based on production simulation and control. Vehicle variety, safety and environmental friendliness are the major customer/society oriented perspectives to be addressed as well. The consortium embraces major stakeholders of the European automotive industry, i.e. a group of OEMs, a group of material manufacturers and parts/equipment suppliers and a group of RTD partners, all well known for their expertise and infrastructure. DaimlerChrysler AG will act as the IP's Co-ordinator.'",Multi-Functional Materials and related Production Technologies Integrated into the Automotive Industry of the Future,FP6,31 December 2010,01 January 2007,4199617.0 FUTURENANONEEDS,University College Dublin,health,"Rapidly developing markets such as green construction, energy harvesting and storage, advanced materials for aerospace, electronics, medical implants and environmental remediation are potential key application targets for nanomaterials. There, nanotechnology has the potential to make qualitative improvements or indeed even to enable the technology. Impacts range from increased efficiency of energy harvesting or storage batteries, to radical improvements in mechanical properties for construction materials. In addition, concerns of these markets such as scarcity of materials, cost, security of supply, and negative environmental impact of older products could also be addressed by new nano-enabled materials (e.g. lighter aircraft use less fuel). FutureNanoNeeds will develop a novel framework to enable naming, classification, hazard and environmental impact assessment of the next generation nanomaterials prior to their widespread industrial use. It will uniquely achieve this by integrating concepts and approaches from several well established contiguous domains, such as phylontology and crystallography to develop a robust, versatile and adaptable naming approach, coupled with a full assessment of all known biological protective responses as the basis for a decision tree for screening potential impacts of nanomaterials at all stages of their lifecycle. Together, these tools will form the basis of a 'value chain' regulatory process which allows a each nanomaterial to be assessed for different applications on the basis of available data and the specific exposure and life cycle concerns for that application. Exemplar materials from emerging nano-industry sectors, such as energy, construction and agriculture will be evaluated via this process as demonstrators. The FutureNanoNeeds consortium is uniquely placed to achieve this, on the basis of expertise, positioning, open mindedness and a belief that new approaches are required.",Framework to respond to regulatory needs of future nanomaterials and markets,FP7,31 December 2017,01 January 2014,6799997.0 FV-TR-SMS,Technion Israel Institute of Technology,energy,"'“The development of renewable energy - particularly energy from wind, water, solar power and biomass - is a central aim of the European Commission's energy policy. Renewable energy sources are expected to be economically competitive with conventional energy sources in the medium to long term.â€ÂMany of the most promising strategies for solar energy conversion involve charge separation of an exciton in a photovoltaic device comprised of a nanostructured composite of various types. We propose to use novel single molecule (particle) modulation spectroscopy techniques to investigate photoinduced charge separation and charge transfer reactions in model photovoltaic solar energy devices based on nanoparticles. We believe that this general strategy will ultimately lead to new tools for photovoltaic device and materials research that will be single molecule spectroscopy (SMS) “functional equivalents†for photo-electro-chemistry and ultrafast spectroscopy. In particular, this proposal takes a new direction in solar energy conversion research by developing and applying a new technique, Fluorescence Voltage-Time Resolved-Single Molecule Spectroscopy (FV-TR-SMS). This method involves simultaneous and synchronized SMS E-Field modulation, and light intensity modulation and/or pulsed lasers. Preliminary FV-TR-SMS results demonstrate that these methods are well suited to study the kinetics of photoinduced charge separation and transfer at the molecular level, and will allow us investigate in the proposed research critical unresolved issues regarding how charge separation and charge transfer processes depend upon chemical structure, morphology and the physical state (e.g. charging) of the layers and interfaces in the model photovoltaic solar energy devices.'",Time Resolved Single Molecule Spectroscopy Studies of Photoinduced Charge Separation and Charge Transfer in Model Photovoltaic Solar Energy Devices,FP6,30 November 2008,01 December 2005,271191.96 FWMIMAGING,Cardiff University,health,"The objective of this research project is to develop a novel multiphoton microscopy technique and to investigate its application to selected problems in cell biology which require sensitive three-dimensional imaging, in-vivo and real time. This novel technique is based on the detection of the resonant coherent non-linear optical response (four-wave mixing) of colloidal quantum dots (CQDs) to explore their application as bio-labels beyond their fluorescence properties. This method would retain many of the advantages of multiphoton fluorescence microscopy, such as intrinsic sectioning capability, and would offer additional advantages such as coherent detection free from fluorescence backgrounds. We expect the spatial resolution to be increased by a factor of two due to the optical non-linearity, resulting in a 130nm of lateral resolution at 550nm exciting wavelength and objectives with 1.3 NA. To compare advantages and disadvantages of this novel coherent optical microscopy technique with respect to confocal/multiphoton fluorescence microscopy, we will investigate a model system, namely HeLa cells, which provides well established routes for biolabelling using both dye-labelled antibodies, protein fusions with fluorescent tags and bioconjugated colloidal quantum dots. The application of this microscope has the potential to bring a significant step forward in the fundamental understanding of major areas in cell biology, which can not be fully addressed with the conventional fluorescence microscopy tools. Moreover, the dependence of fundamental electronic properties, such as homogeneous linewidth of excitonic transition and exciton-phonon interaction, on the size and composition of quantum dots will be investigated via the measurements of the transient four-wave mixing signal as a function of temperature. This study will help assessing the applicability of CQDs, beyond bioimaging, in areas such as quantum information processing, spintronics, and optoelectronics.",Study of coherent non-linear optical response of nanoparticles and application to multiphoton imaging in cell biology,FP7,14 May 2010,15 May 2008,178874.0 GAKO2007CA,University of Cassino and Southern Lazio * Università degli studi di Cassino e del Lazio Meridionale,information and communications technology,"The mathematical multiscale theories intensively developed in the last decades and collected high potential of theoretical methods. These methods are not completely used in engineering, although there exists a great variety of arguments evidently related to problems treated by the multiscale theories. The aim of this project is to give a contribution for closing this 'gap' through joint work of mathematicians, mechanics and engineers. The specific goal of the project is to develop multiscale methods in nanotechnologies with orientation to prediction of new effects in complex structures as nano MEMS (Micro-Electro-Mechanical Systems). We hope that the effects found not only will demonstrate effectiveness of mathematical multiscale theories as method solution of applied problems but will lead to design new structures, materials and devices.",Development of multiscale methods in planning of nano MEMS,FP7,02 June 2011,02 July 2009,224573.28 GAKO2007CA,Siberian State University of Telecommunications and Information Sciences,information and communications technology,"The mathematical multiscale theories intensively developed in the last decades and collected high potential of theoretical methods. These methods are not completely used in engineering, although there exists a great variety of arguments evidently related to problems treated by the multiscale theories. The aim of this project is to give a contribution for closing this 'gap' through joint work of mathematicians, mechanics and engineers. The specific goal of the project is to develop multiscale methods in nanotechnologies with orientation to prediction of new effects in complex structures as nano MEMS (Micro-Electro-Mechanical Systems). We hope that the effects found not only will demonstrate effectiveness of mathematical multiscale theories as method solution of applied problems but will lead to design new structures, materials and devices.",Development of multiscale methods in planning of nano MEMS,FP7,02 February 2013,02 March 2012,15000.0 GALACTIC,University of Strasbourg * Universitè de Strasbourg,information and communications technology,"GALACTIC will offer an extremely talented and promising young researcher, with a PhD in chemistry and an extraordinary track record, world-class training through research in the cross-disciplinary and supra-sectorial field of organo-graphene electronics. The proposed research lies at the interface between supramolecular chemistry, solid-state physics and electrical engineering in the exciting new domain of graphene nanomaterials science. The overall mission is to train the fellow to become an independent scientist as well as to prepare her for a leading position in academia or industry in Europe.",Graphene bAsed switchabLe mAterials - towards responsive eleCTronICs : An Intra-European Fellowship for career development,FP7,04 June 2018,05 January 2014,0.0 GALAXY,Leibniz Institute Innovations for High Performance Microelectronics * Leibniz-Institut für innovative Mikroelektronik,information and communications technology,"This project builds on a technology approach in which the EU currently has world leadership, thanks to previous pan-European funding, and in which the participants are recognised centres of excellence. We propose to provide an integrated GALS (Globally Asynchronous, Locally Synchronous) design flow, together with novel Network-on-Chip capabilities, that will materially aid embedded system design for a significant class of problems. We aim to remove existing barriers to the adoption of the technology by providing an interoperability framework between the existing open and commercial CAD tools that will support development of heterogeneous systems at the different levels of abstraction. The project will evaluate the ability of the GALS approach to solve system integration issues and, by implementing a complex wireless communication system on an advanced 45nm CMOS process, explore the low EMI properties, inherent low-power features and robustness to process variability problems in nanoscale geometries.",GALS InterfAce for CompleX Digital SYstem Integration,FP7,11 June 2012,12 January 2007,2900000.0 GAMBA,Klinikum rechts der Isar der Technischen Universität München,health,"This consortium develops a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The S&T objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform is going to implement a concept of spatiotemporal control of regenerative bioactivity on command and demand. A gene-activated matrix is a biomaterial with embedded gene vectors that will genetically modify cells embedded in the matrix. The platform comprises modules that self-adapt to the biological environment and that can be independently addressed with endogenous biological and exogenous physical or pharmacological stimuli, resulting in a temporally and spatially coordinated growth factor gene expression pattern. This reproduces, within the matrix, key elements of natural tissue formation. The modules are a biomimetic hyaluronan gel, a ceramic matrix, growth factor-encoding gene vector nanoparticles, magnetic nanoparticles and mesenchymal stem cells. Anatomical adaptivity is achieved with engineered thermal properties of the polymer matrix, which embeds other modules, selected according to functional requirements. Mechanical support is provided by Micro Macroporous Biphasic Calcium Phosphate (MBCPâ„¢), a resorbable material approved for clinical use. Spatiotemporal control of bioactivity and responsiveness to physiological conditions is represented, firstly, in the spatial distribution and release profiles of gene vectors within the composite matrix and, secondly, by letting local and external biological or physical stimuli activate the promoters driving the expression of vector-encoded transgenes. This innovative concept is implemented by a multidisciplinary team from leading European institutions combining scientific excellence with a focused plan of dissemination, public participation, gender equality and transition to market.",Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis,FP7,31 August 2013,01 September 2010,3198849.0 GANANO,Technical University Ilmenau * Technische Universität Ilmenau,health,"The goal of the project is to develop a novel Gallium Nitride (GaN) based integrated system for fast physical, chemical, and biological analysis of metabolits, Pharmaceuticals, proteins and pathogens in aqueous nano- and pico-droplets. The research is motivated by the need of hospitals and laboratories for tools enabling identification and screening of large numbers of samples contaning small volumes of disease-associated substances. High-rate, efficiency, and sensitivity of analytical sample-processing that are crucial for early detection of substances associated with diseases such as AIDS or Creutzfeldt-Jakob will directly contribute to improved quality of life and reduction of medical treatment costs. GaNano explores the frontiers of nanotechnologies through development and integration of electronic sensor arrays, optical components (visible and UV light emitters and detectors), and a nano-fluidic dosing device, to form a multifunctional system based on GaN micro- and nanostructures. Optimised for physical, chemical, and biological analysis of very small amounts of liquid, the system will support long-term innovations in bio-medical applications, industrial testing, and development of Pharmaceuticals. Specific objectives are to: - process GaN based electronic sensor arrays on transparent chips for chemical and physical analysis of nano- and pico-droplets, - develop InAIGaN/GaN optical sensor arrays combining UV light emitting and laser diodes with detector arrays for spatially and energy resolved fluorescence spectroscopy, - modify an inkjet-like dosing system for nano- and pico-droplets containing large biopolymer assemblies such as proteins or viruses, - develop and apply organic test substances and optical markers for nano- and picofluidic systems and functionalise sensor surfaces enabling selective biological characterisation, - integrate the dosing system with the electronic and optical sensor arrays into a multifunctional system.",New Generation of GaN-based sensor arrays for nano- and pico-fluidic systems for fast and reliable biomedical testing,FP6,31 December 2006,01 January 2004,2398400.0 GANOMS,Paris Diderot University * Université Paris Diderot - Paris 7,information and communications technology,"A Nano-OptoMechanical System (NOMS) is an ideal interface between nanomechanical motion and photons. The merits of such a system depend crucially on the level of optical/mechanical coupling. For sufficient coupling, the nanomechanical motion is efficiently imprinted on photons and read-out with the assets of optical detection: broadband, fast, ultra sensitive (ultimately quantum limited). Moreover, in a NOMS, the very dynamics of the motion (its frequency, damping, noise spectrum) can be controlled by optical forces. This opens novel roads for nanomechanical sensing experiments, both classical or quantum, that need now to be experimentally investigated and brought in compliance with future on-chip applications.",GaAs Nano-OptoMechanical Systems,FP7,01 July 2020,02 January 2013,0.0 GAPJUNCTION STRENGTH,Curie Institute * Institut Curie,health,"Gap junctions are intercellular channels present in almost all epithelia and in many other specialized tissues. The correct function and formation of gap junctions are involved in diseases such as hypertension, deafness or cataracts. Gap junctions are formed by pairs of hexameric half-channels called connexons, which coaxially dock to connect two adjacent cells, assuring communication, signalling and adhesion between cells. Junctional microdomains are known to be form by thousands of closely packed connexon pairs. Even if the function as intercellular channels of gap junctions is widely studied, the forces supported by connexon pairs and the biophysical mechanism of microdomain formation are still unknown. The overall goal of this project is to determine the biophysical mechanisms of the adhesion strength of gap junctions. The proposed research will make use of state of the art biochemistry methods to purify and reconstitute connexons from eye lens fiber cells into raw membranes extracts. These will be combined with high end biophysical tools, atomic force microscopy and biomembrane force probe, to directly measure the binding forces between connexon pairs and to determine the kinetics and biophysical mechanisms of the aggregation and assembly of gap junctions. The expected outcomes of the proposed research will provide the first direct measure, at single and multiple molecule levels, of the adhesion strength of gap junctions explaining its underlying biophysical mechanisms. The interest of the project covers disciplines such as biophysics, molecular biology and nanotechnology.",Biophysical determinants of the adhesion strength of gap junctions,FP7,31 May 2011,01 June 2009,168279.0 GASNOW,Rovira i Virgili University * Universitat Rovira i Virgili,manufacturing,"This proposal has two main aims: to perform high quality scientific and technological research, and to give training to an experienced researcher to establish her as an independent researcher. Scientific goals Fabrication of nanostructured WO3 as Gas Sensor material using Chemical Vapour Deposition WO3 is one of the most used materials for gas sensing, due to its sensitivity and stability. However, it does not show a very good selectivity, and the fabrication process is often long and expensive. This project investigates the improvement of the selectivity and sensitivity of WO3 by depositing it as nanowires. To perform this, the use of a hybrid (combined) Atmospheric Pressure and Aerosol Assisted Chemical Vapour Deposition (AP/AACVD) is proposed; this technique is very cheap, simple and could be easily industrialised. The modification of WO3 will be also investigated: noble metal nanoparticles (i.e. Au, Ag, Pt) and Carbon NanoTubes (CNT) will be used to modify the gas sensor surface. In this way the selectivity of the sensor is greatly improved. The main scientific/technological outcome of the project will be the fabrication of prototype gas sensor devices, achieved by performing the deposition on appropriate gas sensors substrates, such as alumina and micro-hot-plate. Training goals The training given to the researcher will consist of both scientific and transferable skills. Scientifically, she will gain knowledge in Materials Science (experience in gas sensors materials) and Electric Engineering (instruments and devices). The latter one is particularly important for her, considering her Chemistry/Materials Science background – she will broaden her skills and expertise. Regarding transferable skills, she will be mentored by the scientist in charge in tasks such as research proposal writing, student supervision, and project management and coordination. All these activities will help her to improve her profile and establish her as an independent researcher.",Gas Sensor NanoWires by Chemical Vapour Deposition,FP7,04 June 2014,05 January 2010,210933.51 GELBRID,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"GELBRID is a 3-year project aiming at the preparation and extensive characterization of advanced gel hybrid materials. Three basic strategies will be addressed: (i) peptide-substituted linear pi-conjugated molecules to be gelated and (ii) used as scaffolds for the hybridization with inorganic nanoparticles and for (iii) noncovalent functionalization of graphene through self-assembly. The final target is (iv) a new gel hybrid system that, combining the above 3 strategies, incorporates their outstanding structural and electronic properties. The intrinsic features of the materials fabricated will make them attractive in applicative areas such as advanced nanomaterials, light harvesting, and solar energy conversion. The applicant has a seven-year research experience acquired in world class laboratories in India and Japan and will bring to Europe his expertise in the fields of design, synthesis, self-assembly and gelation of organic molecules as well as in the preparation of hybrid nanomaterials. The host institution (CNR, Italy) will offer him an internationally recognized expertise in the area of advanced physical characterization, supramolecular chemistry, and photosciences. The mutual transfer of knowledge will allow to gather the intellectual and infrastructural critical mass needed to reach the ambitious goal of preparing fully characterized unprecedented organic-inorganic hybrid gel nanomaterials fabricated through self-assembly. The original concepts elaborated in GELBRID are expected to have a noticeable impact in materials science, also thanks to their potential in solar conversion technologies that are currently growing at an impressive pace. The one-year return phase to India is intended to be an instrument to reinforce the scientific cooperation between India and Europe, also taking advantage of an already existing network of collaboration between the host institution and a number of big companies, SME and academic institutions all across the continent.",pi-Electronic Gel Hybrids: Towards Smart Photoactive Nanomaterials,FP7,14 October 2013,15 October 2011,189112.0 GEMINI,Polytechnic University of Milan * Politecnico di Milano,health,"We aim at laying the foundations of a novel paradigm in optical sensing by introducing molecule-specific strong light-matter interaction at mid-infrared wavelengths through the engineering of plasmonic effects in group-IV semiconductors.The key enabling technology is the novel germanium-on-silicon material platform: heavily-doped Ge films display plasma frequencies in the mid-infrared range. This allows for the complete substitution of metals with CMOS-compatible semiconductors in plasmonic infrared sensors, with enormous advantages in terms of fabrication quality and costs. Moreover, the mid-infrared range offers the unique opportunity of molecule specificity to target gases in the atmosphere, analytes in a solution or biomolecules in a diagnostic assay.We will develop sensing substrates containing infrared antennas and waveguides with antenna-enhanced detectors. Antennas and waveguides will be made of heavily-doped Ge to fully exploit plasmonic effects: high field concentration to increase sensitivity, resonant coupling to vibrational lines for chemical specificity, deeper integration to decrease costs. To achieve our goals we will rely on semiconductor growth by chemical vapor deposition, electromagnetic simulations, micro/nanofabrication of devices and advanced infrared spectroscopy. We aim at studying the fundamental properties of new materials and devices in order to assess their potential for sensing.Impacts of the proposed research go far beyond transforming optical sensing technology. Lab-on-chip disposable biosensors with integrated readout for medical diagnostics would radically cut healthcare costs. The possibility of actively tuning electromagnetic signals by electrical and/or optical control of the plasma frequency in semiconductors holds promises for dramatic opto-electronic integration. Finally, plasmonic semiconductor antennas will impact on photovoltaics, light harvesting and thermal imaging.",GErmanium MId-infrared plasmoNIcs for sensing,FP7,31 January 2017,01 February 2014,1737205.0 GENEPHYSCHEM,Pierre and Marie Curie University * Université Pierre et Marie Curie,health,"We propose to undertake a new challenge: the control of gene expression systems by physico-chemical means to achieve the following objectives: i) developing robust tools for spatio-temporal control of protein expression; ii) understanding the role of micro-environmental factors in gene regulation; and iii) constructing and implementing in vivo smart nanomachines able to express active molecules in response to a stimulus and deliver them to a targeted cell. First, various biochemical processes (transcription, translation) will be controlled by light in vitro, based on photo-induced conformational changes of nucleic acids (DNA, RNA) and chromatin. Based on conformational changes rather than specific template-protein interaction, and combined with microfluidic methodologies, this novel approach will provide a ubiquitous tool to address gene expression using light regardless of the sequence, with unique control and spatio-temporal resolution. Second, by reconstituting photo-responsive gene expression systems in well-defined giant liposomes, we will study the dynamics of gene expression in response to light stimulation. This will allow us to establish the respective roles of the membrane (surface charge, permeability) and of the inner micro-environment composition (viscosity, molecular crowding). Third, we will develop stable, long-circulating polymer nanocapsules (polymersomes) encapsulating a gene expression material that can be triggered by light and/or molecules of biological interest. In response to the signal, an exogenous, potentially immunogenic enzyme will be expressed inside the protecting nanocapsule to locally and catalytically convert a non toxic precursor present in the medium into a cytotoxic drug that will be delivered to a cell (e.g., a cancer cell). This new concept of triggerable gene-carrying nanomachines with unique amplification capacity of drug secretion shall open new horizons for the development of smart biological probes and future therapeutics.",Spatio-temporal control of gene expression by physico-chemical means: from in vitro photocontrol to smart drug delivery,FP7,31 December 2015,01 January 2011,1450320.0 GENETIC NANOPROBES,Technion Israel Institute of Technology,health,"Achieving a quantitative understanding of the transcriptome is critical to the development of RNA biology and RNA-based therapeutics. One of the main 'road-blocks' to the advancement of these fields is the inability, at present, to dynamically track most RNA molecules in vivo. In order to achieve a quantitative understanding of RNA interactions in vivo, we propose to develop a new class of genetically encoded fluorescent probes that will be designed to dynamically track gene expression (mRNA), miRNA trans-interactions, riboswitch or hairpin-type cis-interactions, ribozyme, and any other class of ncRNA. The probes will consist of large self-assembled RNA-FP complexes that will report RNA-RNA interaction dynamically via an engineered structural change that will be detected through a change in fluorescence. The signal will consist of a change in the light polarization, and will be detected by a novel implementation of a polarization Total Internal Reflection Fluorescence (polTIRF) microscope design, which will enable the detection of small structural changes within the nanoprobe at fast sampling rates. In this proposal, I intend to develop, in bacteria, the first generation of these probes. Development of the probes and the imaging apparatus will take place simultaneously, in order to optimize both detection capability and the probe design. The development and demonstration of the probes' capabilities will be guided by three objectives, each divided into individual milestones and sub-projects. In particular, I intend to use this approach to quantitatively characterize synthetic hammerhead ribozyme trans interaction, cis-acting RNA thermosensors, and the Hfq RNA-protein complex. I believe that successful implementation of this combined molecular and imaging tool to quantitatively characterize the kinetics associated with RNA-RNA trans/cis-interactions will constitute a proof-of-principle to the broad applicability for our method to other RNA-based platforms.",GENETICALLY ENCODED FLUORESCENT NANOPROBES FOR DETECTION OF RNA INTERACTIONS,FP7,31 July 2016,01 August 2012,100000.0 GENHYPEM,University of South Paris * Université Paris-Sud,energy,"GenHyPEM is a project related to the electrolytic production of hydrogen from water, using proton exchange membrane (PEM) - based electrochemical generators. The specificity of this project is that all basic research efforts are devoted to the optimization of already existing electrolysers of industrial size, in order to facilitate the introduction of this technology in the industry and to propose technological solutions for the industrial and domestic production of electrolytic hydrogen. GenHyPEM gathers partners from academic institutions and from the industry who will provide a 291 man-month research effort over three years, in order to reach three main technological objectives aimed at improving the performances of current 1000 Nliter/hour H2 industrial water electrolysers : (i) Development of alternative low-cost membrane electrode assemblies and stack components with electrochemical performances similar to those of state-of-the-art systems. The objectives are the development of nano-scaled electrocatalytic structures for reducing the amount of noble metals; the synthesis and characterization of non-noble metal catalytic compounds provided by molecular chemistry and bio-mimetic approaches; the preparation of new composite membrane materials for high current density, high pressure and high temperature operation; the development and optimization of low-cost porous titanium sheets acting as current collectors in the electrolysis stack. (ii) Development of an optimized stack structure for high current density (1 A.cm-2) and high pressure (50 bars) operation for direct pressurized storage. (iii) Development of an automated and integrated electrolysis unit allowing gas production from intermittent renewable sources of energy such as photovoltaic-solar and wind.",Proton Exchange Membrane- based Electrochemical Hygrogen Generator,FP6,31 December 2008,01 October 2005,1300000.0 GENIUS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"GENIUS aims at offering highest-quality supra-sectoral and cross-disciplinary training to a pool of promising young researchers, in an area at the interface between Supramolecular Chemistry, Materials- and Nano-Science, Physics and Electrical Engineering. GENIUS appointees will be trained in lecture courses, dedicated schools and workshops, and through an ambitious and carefully planned research activity that benefits both from the expertise of world-leading PIs with remarkable track records in both training and research. GENIUS is designed to generate new scientific and technological knowledge on the production, processing and characterization of graphene based supramolecular architectures, taking advantage of the outstanding physical and electronic properties of graphene. We are particularly interested in developing and studying a new graphene-organic hybrid material (GOH) for applications in microelectronics; the new material proposed, while maintaining the excellent properties of classical graphene, will have improved processability in solution, chemical functionalization and tunable optoelectronic properties. We will use supramolecular interactions to cover single graphene sheets with polycyclic aromatic hydrocarbon molecules, i.e. nano-graphenes (NG), which are composed of i) an aromatic core able to interact strongly with graphene, and ii) flexible side chains to provide solubility in organic solvents. NGs adsorb reversibly on graphene by pi-pi interactions, forming ordered adlayers on its surface with pre-programmed molecule spacing and orientation, ultimately modulating the electronic properties of the GOH. The interaction of NG and graphene will be studied at macroscopic scale by optical, Raman and current-voltage spectroscopy, and at molecular and microscopic scales primarily by Scanning Probe Microscopies. As a proof of principle, field effect transistors and photovoltaics devices based on graphene-NG composites will be tested.",GraphenE-orgaNIc hybrid architectures for organic electronics: a mUltiSite training action,FP7,30 November 2014,01 December 2010,4321902.0 GENOTYPING NANOPORES,Technion Israel Institute of Technology,health,"The rapidly decreasing costs of DNA sequencing have made the genomic sequences from thousands of pathogens broadly accessible. The utilization of this new knowledge in clinical practice, however, critically depends on the availability of new analytical tools and techniques that could quickly and efficiently detect the presence of specific genomic variants of pathogens. Some recent examples include the outbreak of H1N1 (Swine flu) and HIV-AIDS. Current approaches rely on costly and time-consuming Polymerase Chain Reaction (PCR), to achieve the specificity and quantity required by standard means of detection. Here I propose to develop a radically low-cost, single-molecule, genotyping method based on nanopore sensing of Peptide Nucleic Acids (PNA) markers. This method is designed to yield an extremely low cost, single-molecule detection of viral infections. Nanopores are emerging single-molecule sensors, where an electrophoretic force threads DNA or RNA biopolymers, into a nanoscale aperture made in a thin film. The threading process uncoils the biopolymers, as they move from one side of the film to the other. Molecules entering the nanopore occlude some of the free ions in the solution from the pore volume, thus permitting real-time electrical detection of the local cross-section of the biopolymer. We propose to develop this method to permit the rapid detection of sequence-specific PNA markers, known to invade double-stranded DNA and form bulges at the points of invasion. We recently showed that PNAs can be detected using tiny solid-state nanopores. To transform this discovery into a robust analytical tool, extensive studies are now required to critically improve the nanopore fabrication, the signal over noise of the measurements, and the biomolecular strategies for efficient PNA invasion. Our studies will ultimately enable the development of low-cost, portable, and high-throughput devices for a broad range of genome based molecular diagnostics.",Genotyping using solid-state nanopores and Pepetide Nucleic Acid markers -a new tool for single-molecule molecular diagnostics,FP7,28 February 2015,01 March 2011,100000.0 GI-MRI,University of Zurich * Universität Zürich,health,"Understanding the function of the gastrointestinal (GI) tract and its relation to abdominal symptoms and digestion is of fundamental importance in clinical medicine. Existing techniques are not able to describe the integrated, regulated mechanism by which foods are digested and drugs are delivered to the bowel. It is for these reasons that the causes of abdominal symptoms often remain unclear and that oral therapies for systemic conditions complicated by GI dysfunction are ineffective. This project will develop and apply MRI technology to assess the flow, mixing and transit of nutrients and oral drugs through the GI tract. Dynamic 1H-MRI will provide a comprehensive assessment of GI function and be combined with novel 19F-MRI that follows the passage of GI contents. Results will be validated and extended by 13C breath testing. The primary objective is to develop multi-nuclear MRI for use in physiologic measurements of GI function (1H-MRI) and delivery of nutrients/drugs (19F-MRI). This includes the optimization of accelerated 3D 1H-MRI for detecting GI function in long bowel segments and 19F-MRI utilizing (nano-)capsules containing a stable fluorocarbon as an oral contrast agent. This technology will be applied in clinical studies of two important diseases to assess whether these developments provide novel insight into the mechanism of disease: (1) Diabetic Mellitus, to assess how gastroparesis leads to abnormal nutrient delivery and impaired glycaemic control. (2) Parkinson's Disease, to assess how gastric dysfunction affects the delivery and absorption of levodopa and its efficacy for treatment of tremor and rigidity. This project will maintain the leading position of European researchers in MRI assessment of GI function, a technology that is likely to enter clinical practice in the next years. It will increase knowledge about the identification and management of GI complications in DM and PD, chronic diseases that are stated priorities of the FP7 work program.",Dynamic and multi-nuclear magnetic resonance imaging for the assessment of nutrient and drug delivery in the human gastrointestinal tract,FP7,31 July 2012,01 August 2010,180470.0 GIBON,Alcatel Thales III-V Lab,information and communications technology,"This project addresses the challenges of very high bit rate opto-electronics transceivers suitable for 100 Giga Ethernet type applications. Observation of the steady improvement in Silicon CMOS performances, as well as the increase in data traffic projections, are incentives for this evolution, expected to become an industrial reality in the first part of the next decade. In this project, the focus is on the demonstration of the highest speed components that integrate the optoelectronic transducers (light modulator and photodiode) with their driving electronics (driver and preamplifier respectively). Really new optoelectronics components will be developed based on designs experienced for lower bit rates (40 and 80 Gbit/s) and their characteristics will be optimised in order to match specifications that will be derived from systems considerations. As important as the optoelectronic devices characteristics themselves is the Opto-Electronic Integrated Circuit technology that will be used for the transceivers. Two parallel routes will be followed in this project for the transmitter and receiver : while the monolithic integration is chosen for the later, with its associated advantages of lower added parasitics and shorter interconnections than conventional approaches, a flip-chip integration is to be used for the former, to benefit from optimised technologies for both the Electro-absorption Modulated Laser and the electronic driver and to better accommodate thermal issues. Guidelines for this production of integrated devices as well as for the components packaging will be given by a supporting Electro-Magnetic simulation activity. This project will be completed by an assessment of the fabricated components with respect to the projected application.",Opt-electronic integration for 100 Gigabit Ethernet Optical Networks,FP6,31 July 2009,30 April 2006,1850000.0 GLASCOAT,London South Bank University,construction,"The available industrial processes for depositing thick glass coatings (enamelling and glazing) have serious disadvantages. The coatings are low strength, temperature-sensitive materials cannot be coated and also large components or structures outside cannot be coated. Furthermore, the processes are low-technology, vulnerable to competition from low-wage economies and consequently are in decline. The proposal will develop a new integrated process based on modified plasma spraying and combustion flame spraying coupled with infrared crystallization. It is aimed at overcoming the weakness of the available processes and widening application of the glass coatings. The proposed project will develop high-performance nanostructured glass-ceramic coatings and glass-based nanocomposite coatings. These have not been made before. High-strength glasses have high fuse temperatures and cannot be coated onto metal substrate by traditional enamelling. The proposal will employ recent sol-gel techniques to make nanostructured particles, which will be spray-dried to feedstock powder and then plasma (or combustion) sprayed. The rapid thermal cycle of spray- deposition preserves the nanostructure and suppresses crystallization. Near infrared radiation immediately after spraying will be used to control the nucleation and growth of the amorphous phase to produce nanostructured glass-ceramic coatings. For glass-based nanocomposite coatings, the nanoparticles will be added to the base glass at the gel stage. Computational modelling will facilitate the understanding of the fundamental processes, enhance control and provide a science-based methodology for equipment design. The new technology will allow high-performance glass coatings to be produced with potential applications in, for example, machine tools, textile machinery, automotive and chemical industries. The process will also enable temperature-sensitive materials (e.g. concrete and cast iron)#",HIGH-PERFORMANCE GLASS-BASED COATINGS,FP6,30 September 2007,01 January 2004,1077950.0 GLOBASOL,University of Eastern Piedmont * Università degli Studi del Piemonte Orientale,energy,"GLOBASOL will develop new concepts, materials and devices for advanced light harvesting and light management for a panchromatic collection of the solar energy and an unprecedented power conversion efficiency. This will be accomplished by integrating in a single device three light-to-electricity converters, exploiting different regions of the solar spectrum based on sensitized mesoscopic solar cells (SMSC), photonic crystals, thermoelectric (TE) cells. The key elements of the project are: 1) new absorbers for SMSC, with a very high conversion efficiency in the UV-vis region; 2) novel photonic materials for the collection/split of the IR spectrum; 3) advanced nanostructured materials for TE conversion of the IR part of the spectrum; 4) radically new architectures for the integrated devices, to increase the total efficiency. The innovative materials will include organometallics, organic dyes and quantum dots as sensitizers, quasi-solid electrolytes, nanostructures and nanowires alloys as well as quantum dots for TE. The devices will be engineered either in tandem arrangements or with optical splitting of the incident radiation, and concentration of the IR fraction to the TE. The targeted power conversion efficiencies are above 15% and 10% for SMSC in high and medium energy spectral regions, respectively, and 6% for TE, to reach a global efficiency above 30%, well beyond the present limits, along with cost-effectiveness and environmental safety. Five Universities and one Research Institution guarantee a scientific and technological multidisciplinary research, based on top level theoretical and experimental approaches. The high degree of knowledge in solid-state physics and chemistry, nanoscience and nanotechnology and engineering of the researchers assures that the new concepts and the objectives proposed will be successfully developed/pursued. A high-tech SME will provide proof-of-concept prototypes to validate the innovative GLOBASOL devices.",Global solar spectrum harvesting through highly efficient photovoltaic and thermoelectric integrated cells,FP7,29 February 2016,01 March 2013,2995040.0 GLOSS-EE,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,photonics,"Electronic replacement of printed paper, e-paper, will have drastic impact on the world we live in. Millions of sheets of printed papers in offices around the globe are consumed every day. It is believed that electronic devices for document reading will seriously reduce the load this imposes on our environment. Moreover, high quality e-paper enables the dream of having information distribution anytime, anywhere. Today’s e-paper devices have very serious shortcomings. They can by far not reach the “whiteness†and contrast of printed text on paper, and they cannot show colour images. This hampers the acceptance of e-paper in the market.Philips has identified that it is important to have a colour e-paper for increasing the dissemination of information. Therefore, a project team has started developing the technology for colour reflective displays. This team has identified gaps in their knowledge that have to be filled. In the fast changing world of information technology, it is important that these gaps are filled quickly. The objective of the ToK is to explore and develop new materials, processes and components for high quality colour e-paper. Three fellows are necessary to bring scientific know-how in the following areas:- Innovative ways of building nano-particle based e-paper displays using self-organizing assembly methods involving functional polymers.- Nanoporous materials offering a low refractive index and new ways to tune their optical properties need to be developed. - New diffractive optical components and photonic bandgap materials will be explored and the state of the art in optical telecommunication technology will be transferred into the new area of e-paper displays. Joining the scientific knowledge of the fellows with the application experience of the host will lead to a new colour e-paper display technology.",Glossy Magazine Quality Colour E-Paper,FP6,31 January 2009,01 February 2005,492204.0 GLYCOGOLD,Universiteit Utrecht * Utrecht University,health,"The aim of the RTN is to explore the potential of gold Glyco-Nano-Particles (GNPs), to deepen the understanding ofbiomolecular interactions and to solve biomedical problems. The innovative combination of a variable metallic core with aselected set of ligands can turn GNPs into vaccines or anti-adhesion agents or dedicated vehicles to deliver compounds safely at their target location.GlycoGold will operate as a virtual research training centre at the interface of physics, chemistry, immunology, molecularbiology, and bioinformatics. It integrates and expands the knowledge base and infrastructures of the partners. It has workpackages (WPs) that deal with materials, tools and insight into biomolecular interactions, and WPs geared towards theapplication of GNPs as vaccines, and control of interactions. The Training&Mobility and Design&Innovation WPs and activenetworking ensure a smooth project workflow. The tasks are assigned to international task forces.The research is timely, because the required techniques have evolved to a point that an integrated multinational approach isviable. Secondly, interest of industries in obtaining this information is high. Thirdly, the necessary overall knowledge to perform the research in a single laboratory does not exist in Europe, and very few graduates have the integrated knowledge to operate in this area, despite the large demand for them.The network provides an interdisciplinary training environment for these specialists, where training is offered through (i) handson experience, (ii) summer schools aimed to bridge the knowledge gap between the physical and life sciences, (iii) short courses, lectures, demonstrations and practical training sessions, and (iv) activities for individual career development.Dedicated international and multilingual science promoting activities are scheduled annually aimed at young science students and in particular at high-school pupils.",GlycoGold: Exploration of the nature and potential of Glyco-nano-particles.,FP6,31 March 2009,01 April 2005,2327423.0 GLYCOHIT,National University of Ireland Galway,health,"Protein glycosylation is a post-translational phenomenon that is involved in most physiological and disease processes including cancer. Most of the known cancer-associated glycobiomarkers were discovered individually using liquid chromatography and mass spectroscopy. Though valuable, there is room for improvement in these approaches for the discovery phase. There is also a critical need for innovative, rapid, and high-throughput (HTP) technologies that will translate the discovery of cancer-associated glycobiomarkers from basic science to clinical application. The GlycoHIT consortium brings a highly experienced, innovative and interdisciplinary team of researchers from Europe, China and USA representing academia, industry and clinical fields to significantly enhance some of the existing glycoanalytical technologies and to advance novel HTP glycoanalytical technologies beyond current state of the art. â–ª Microchip technology and novel partitioning methods will be exploited for nanoscale HTP separations of serum glycoproteins for analysis by HPLC or LC–MS. â–ª In parallel, lectin array technology will be radically improved by the innovative use of recombinant human lectins and lectin mimics derived by screening large phage displayed combinatorial libraries. â–ª Aptamer libraries will be exploited for identification of lectin mimics and development of a glycosignature platform â–ª Compatibility of the lectin/lectin mimic array technologies with novel label-free biosensors will be explored. Newly-developed technologies will be validated by analysis of serum samples from a variety of cancer patient cohorts and will be supported throughout by experimental interaction analysis, complex structural modelling and informatics. Effective project management, commercially-aware intellectual property management and targeted dissemination activities supplement the core science and ensure maximum impact for the project.",Glycomics by High-throughput Integrated Technologies,FP7,30 June 2014,01 January 2011,2993056.0 GLYCOSURF,University of Birmingham,health,"There is now overwhelming evidence that glycosylation changes during the development and progression of various malignancies. Altered glycosylation has been implicated in cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases. Currently, antibodies are playing a central role in enabling the detection of glycoprotein biomarkers using a variety of immunodiagnostic tests. Nonetheless, antibodies do have their own set of drawbacks that limit the commercialization of antibody sensing technology. They suffer from poor stability, need special handling and require a complicated, costly production procedure. More importantly, they lack specificity because they bind only to a small site on the biomarker and are not able to discriminate, for instance, among different glycosylated proteins. The current antibody diagnostic technology has well recognized limitations regarding their accuracy and timeliness of diagnose of disease. This project will focus on research into the means of developing a generic, robust, reliable and cost-effective alternative to monoclonal antibody technology. The project aims to exploit concepts and tools from nanochemistry, supramolecular chemistry and molecular imprinting to provide highly innovative synthetic recognition platforms with high sensitivity and specificity for glycoproteins. Such novel type of platforms will make a profound and significant impact in the broad fields of biosensors and protein separation devices with applications in many areas such as biomedical diagnostics, pharmaceutical industry, defense and environmental monitoring. The proposed technology may open an untraveled path in the successful diagnosis, prognosis and monitoring of therapeutic treatment for major diseases such as cancer, immune deficiencies, neurodegenerative diseases, hereditary disorders and cardiovascular diseases.",Surface-Based Molecular Imprinting for Glycoprotein Recognition,FP7,30 November 2019,01 December 2014,1894046.0 GLYCOTRACKER,Weizmann Institute of Science,health,"Glycobiology is poised to be the next revolution in biology and medicine; however, technical difficulties in detecting and characterizing glycans prevent many biologists from entering this field, thus hampering new discoveries and innovations. Herein, we propose developing a conceptually novel technology that will allow straightforward identification of specific glycosylation patterns in biofluids and in live cells. Distinct glycosylation states will be differentiated by developing 'artificial noses' in the size of a single molecule, whereas selectivity toward particular glycoproteins will be obtained by attaching them to specific protein binders. To achieve high sensitivity and accuracy, several innovations in molecular recognition and fluorescence signalling are integrated into the design of these unconventional molecular analytical devices. One of the most important motivations for developing these sensors lies in their potential to diagnose a variety of diseases in their early stages. For example, we describe ways by which prostate cancer could be rapidly and accurately detected by a simple blood test that analyzes the glycosylation profile of the prostate-specific antigen (PSA). Another exceptional feature of these molecular analytical devices is their ability to differentiate between glycosylation patterns of specific proteins in live cells. This will solve an immense challenge in analytical glycobiology and will allow one to study how glycosylation contributes to diverse cell-signalling pathways. Finally, in the context of molecular-scale analytical devices, the proposed methodology is exceptional. We will show how 'artificial noses' can be designed to target nanometric objects (e.g. protein surfaces) and operate in confined microscopoic spaces (e.g. cells), which macroscopic arrays cannot address. Taken together, we expect that the proposed technology will break new ground in medical diagnosis, cell biology, and biosensing technologies.","Tracking Glycosylations with Targeted, Molecule-Sized 'Noses'",FP7,30 September 2018,01 October 2013,1398429.0 GLYCOTREAT,Stichting VU-VUmc * Foundation VU - VUmc,health,"There is an urgent need to develop vaccines for the induction of CD8+ T-cell immunity to treat cancer and infectious diseases. Dendritic Cells (DC) have shown potential to induce antigen specific CD8+ T-cell responses with the help of CD4+ T cells, yet the efficacy by which the induction is achieved still has its limitations. The main challenge is: (a) to increase targeting efficacy to the complete repertoire of DC subsets; (b) to trigger T-cell responses by the DC that is powerful enough to eliminate a tumour (c) to implement novel human read-out systems, that mimic he human body response to evaluate vaccine efficacy. The aim of this research project is to develop new glycan-based nanomedicines targeted to DC to induce powerful T-cell responses. Within the scope of this research project these new glycan-based nanomedicines will be tested to (i) trigger a strong T-cell response to pathogens, (ii) induce a powerful and adequate T-cell response to self antigen in a tumour induced immune suppressive environment and (iii) render fundamental insights to establish a vaccine platform relevant for the treatment of cancer and infectious diseases. GlycoTreat employs an unconventional, novel glycan biotechnology approach to target a multitude of DC subsets in the human skin to validate the groundbreaking hypothesis that the local administration and molecular size and glycan valency of the targeting compound affect the efficiency of the T-cell stimulating vaccine. This research project joins the chemical design of glyco-nanomedical vaccines with immunological outcomes in our advanced in-vitro, in-situ human skin and in-vivo mouse DC model systems. While crossing the established disciplinary boundaries between chemistry, biology and medicine, Prof. van Kooyk will generate a new field of expertise in vaccine development applied in the field of cancer treatment.",Novel vaccine generation for the treatment of cancer. A glyco-nanomedial approach instructing T cells,FP7,31 January 2019,01 February 2014,2498736.0 GMOSENSOR,Higher Institute of Engineering of Porto * Instituto Superior de Engenharia do Porto (ISEP),health,"Most of transgenic plants are derived from crops of worldwide critical importance to food and feed producers: soybean, maize, rapeseed and cotton. Although the advantages presented by the genetically modified organisms (GMO), such as herbicide tolerance or resistance to insects, their cultivation has raised numerous concerns in the European Union (EU) and other parts of the world about food safety, environmental and economic impact. In spite of it, their production is steadily increasing mainly in the American countries, reaching a global area of 160 million hectares in 2011. To protect consumers, food and feed labelling legislation is in force in EU and other countries such as Brazil. The verification of its compliance demands reliable and accurate GMO detection methods, but also high throughput tools able to rapidly assess the actual prevalence of transgenic material in food and feed, which is unknown. The GMOsensor proposal intends to establish an innovative and well-organised scientific network aiming at advancing on nanobiosensor devices to assess the presence of GMO in food and feed products. The achievement of high throughput sensitive analysis requires novel approaches that combine different research areas. State-of-the-art methodologies and advanced techniques will be incorporated in this research for validation of the new tools and towards the efficient monitoring of transgenic soybean and maize derived products from diverse regions. The application of biosensors in food analysis is well suited due to their easy miniaturisation, simple instrumentation and cost-effective. The use of biosensors is promising since they answer to the demands of high sensitivity, specificity, and fast analysis. In this project, novel qualitative and quantitative bioanalytical methodologies (DNA- and protein-based) are proposed to answer the demands on multitarget analysis to screen and identify authorised and unauthorised GMO.",Monitoring Genetically Modified Organisms in Food and Feed by Innovative Biosensor Approaches,FP7,30 September 2015,01 October 2013,340200.0 GNRSENSE,Tel Aviv University,information and communications technology,"Significant progress and novel discoveries have been made in the past two decades in the science of nanometer scale carbon based materials. Novel physical phenomena characterizing low dimensional systems have been discovered leading to the development of prototype devices. Graphene nanoribbons have very recently emerged at the front of this field due to their unique electronic, magnetic and mechanical properties and the ability to fabricate them in a controllable and reproducible manner. Despite the considerable progress that has been made in the controlled fabrication and the understanding of the physical properties of graphene nanoribbons, currently, much less is known regarding their chemical nature. The large surface to volume ratio and the existence of reactive edges are expected to considerably enhance their chemical reactivity with respect to related systems such as carbon nanotubes and infinite graphene surfaces. Thus, understanding the surface and edge chemistry of graphene nanoribbons and utilizing it for chemical sensing purposes is a major challenge. It is the purpose of this research program to address this challenge. To this end, our proposed program will focus on the development and implementation of a new model that will allow the accurate treatment of the electronic and transport properties of finite extended systems such as graphene nanoribbon surfaces. Using this model we will study in depth the process of molecular adsorption on the surface and edges of nanoribbons and its influence on the electronic properties of the ribbon. Furthermore, we propose to study new schemes to control the reactivity of the ribbon and the selectivity of the adsorption process. We believe that the proposed research program will enhance the understanding of the chemical nature of graphene nanoribbons and will provide guidelines for the design and fabrication of novel nanoscale sensing devices.",Graphene nanoribbon based chemical sensors,FP7,12 July 2015,01 January 2010,100000.0 GOLEM,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"While our knowledge on synthesizing nanostructures at the molecular level is progressing at a fast pace since the remarkable achievement of buckyballs and carbon nanotubes, our current understanding on how to interface and assemble parts from different materials is still limited. The GOLEM concept is to propose an approach based on bio-inspired events to assemble parts at the micro-/nano- scale. The objective is to mimic methods used by nature to interface organic and non-organic material (for example abalone shellfish provide a template for the crystallization of calcite into hard shell) and also, molecular recognition properties like antibodies/antigens, proteins receptors/ligands interaction or DNA hybridization to uniquely define mating pairs between nano-objects to assemble. The assembly process in itself is assisted or partially assisted by way of swarm micro-robots, fluidic systems (to direct a flow of parts) or through laser-trapping techniques. The GOLEM science and technology objectives are: * To understand and investigate the bio-inspired bindings suitable for non-organic materials. * To characterize the assembly process at the micro-/nano- scale (geometry, bonding forces, repeatability, etc.) using dedicated tools. * To develop tools and methods to selectively functionalized surfaces on which bio-molecules are attached to. * To implement a demonstration of assembled device using bio-inspired bonds. GOLEM will contribute at exploring the frontiers of knowledge by a systematic investigation of bio-inspired events as a 'smart-glue' to bond non-organic material. GOLEM will also support long-term innovation by providing specifically developed micro-robotic instruments and methods to investigate nano- and micro- assembly that will be made to the European Research Community.",Bio-inspired Assembly Process for Micro- and Nano- Products,FP6,28 February 2010,01 September 2006,2850000.0 GOMBS,Universiteit Twente * Twente University,health,"The GOMBS project prepares the commercialization of ultrasensitive point-of-care biosensors for early-stage detection of life-threatening diseases, based on the largest MR effect ever observed at room temperature and small magnetic fields, recently discovered by the PI [Science 341, 257 (2013)]. Target biomolecules are specifically attached to the sensor and magnetic nanoparticle (NP) labels, and electrically detected using this huge MR effect (patent in preparation). We will develop sensors for disease markers such as prostate-specific antigen (prostate cancer), troponin (heart muscle damage) and hypermethylated DNA (several cancers). The PI will make use of his long-standing, fruitful collaborations with organic chemists on magnetic NP synthesis and assembly, and functional organic monolayers. As the most competitive advantages of our sensor technology we identify (1) high selectivity, sensitivity and speed (2) very simple, scalable device concept, (3) robustness against environmental fluctuations (e.g. temperature-, pH-independent), (4) small size (allowing implementation in a bioassay device for multiple target molecules), and (5) low cost price. Recognizing commercial potential and a clear market need, the GOMBS team is highly motivated to start up a new venture for exploitation of the proposed biosensor. We will develop the optimal business strategy with an experienced business executive. We will collect market insights for calculating the feasibility, and for setting up a strategic mode of action. In collaboration with a patent attorney a strategy will be defined that secures IP protection. GOMBS will deliver a technical proof of concept and a comprehensive business plan including presentation of the product and concept, the team, business and IP strategy, business model, market size and dynamics, technical and operational planning, a SWOT analysis, investment need, and financial forecasts. This plan will form the basis for the launch of a spin-off company.",Giant Organic Magnetoresistance BioSensing,FP7,30 September 2015,01 October 2014,149999.0 GQEMS,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,information and communications technology,"The aim of this project is to develop a new class of mechanically tunable quantum devices based on graphene. Adopting an innovative and interdisciplinary approach grounded on both engineering-based microsystem technology and low-temperature solid-state physics, we aim at gaining control over the mechanical and electromechanical properties of graphene nano-membranes and suspended graphene nanostructures, in the low and high strain regime.",Graphene Quantum Electromechanical Systems,FP7,12 July 2018,01 January 2012,0.0 GRABFAST,Aalto University * Aalto-yliopisto,health,"Manipulating structure and composition in the nanoscale allows the creation of novel materials with superior performance for new products and devices. The introduction of a wide range of new low-cost nanomaterials is expected to have a disruptive impact on a variety of conventional inorganic semiconductor devices, not only because of performance/cost advantages, but also because they can be manufactured in more flexible ways, suitable for a growing range of applications. Graphene, a single layer of carbon allotrope, exhibits extraordinary optical and optoelectronic properties for ultrafast broadband photonics, including ultrafast response, high mobility, broadband absorption, and gate-variable optical conductivity, in addition to flexibility, robustness and environmental stability. My proposal aims to use graphene to create a new range of ultrafast lasers, such as ultrafast fiber, solid-state, and waveguide lasers. These lasers will break the spectrum and speed bottleneck of existing devices, and thus can provide cost-effective, energy-saving and robust tools with unprecedented speed and bandwidth, ideally fitting a large range of growing and emerging applications, such as high-speed telecommunication, industrial material processing, metrology, medicine and sensing applications. This is an ambitious frontier research program, with a strong interdisciplinary nature, across Engineering, Physics, Chemistry and Matter sciences.",Graphene Based Ultrafast Lasers,FP7,28 February 2018,01 March 2014,100000.0 GRAFIEST,Juelich Research Centre * Forschungszentrum Jülich,information and communications technology,"Graphene is a perfect infinite single layer of sp2-bonded carbon atoms densely packed into a benzene-ring structure. The confinement of electrons in two dimensions and the peculiar symmetry of the carbon network give graphene exceptional electronic properties that make it a promising material for carbon-based nanoelectronics and spintronics. In particular, the performances of such devices rely on the exceptional intrinsic carrier mobility of graphene. However, extrinsic scattering sources due to standard SiO2 substrates limit the mobility. Hence, the quest for alternative substrates is mandatory in order to increase the mobility beyond the extrinsic limits.",Graphene-Ferroelectric Interface for Electronic and Spintronic Technologies,FP7,03 January 2015,09 January 2012,0.0 GRAFOL,University of Cambridge,photonics,"Graphene has some unique properties resulting from its linear dispersion band structure, its high carrier mobility, and its low dimensionality. However, its use is presently limited by its synthesis and mass production. The project aims to develop the first roll-based chemical vapour deposition (CVD) machine for the mass production of few-layer graphene for transparent electrodes for LED and display applications, and adapts the process conditions of a wafer-scale carbon nanotube growth system to provide a low-cost batch process for graphene growth on silicon. The project focuses on applications such as transparent electrodes for OLEDs and GaN LEDs, optical switches, plasmonic waveguides, VLSI interconnects, sensors and RF NEMs.",GRAPHENE CHEMICAL VAPOUR DEPOSITION: ROLL TO ROLL TECHNOLOGY,FP7,30 September 2015,01 October 2011,6900000.0 GRANARIP,MTA - Research Centre for Natural Sciences * Természettudományi Kutatóközpont,information and communications technology,"The development of novel functional nanodevices based on graphene is of great interest for many technological applications. Transferring the bunch of exceptional properties of this highly promising two dimensional carbon material (light, strong, flexible, semi-metal, etc.) is currently one of the hot topics in material science.",Structure-property characteristics of graphene materials with controlled nanoscale rippling,FP7,03 July 2019,04 January 2013,0.0 GRAND,Gesellschaft für Angewandte Mikro- und Optoelektronik mit beschränkter Haftung (AMO GmbH),information and communications technology,"The semiconductor industry is a cornerstone of today’s high-tech economy, supporting over 100,000 direct and even more indirect jobs in Europe. This position has been achieved through continued miniaturization in complementary metal-oxide-semiconductor (CMOS) technology, which will only last for a maximum 10-15 more years. In line with its Lisbon Strategy, the EC has identified an urgent need to assess possible technology solutions for the “Beyond CMOS” era to meet the challenges of global competition._x000d_",Graphene-based Nanoelectronic Devices,FP7,12 July 2012,01 January 2008,0.0 GRANOP,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Graphene, a single-atom layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, the charge carriers have zero effective mass and can therefore travel for micrometers without scattering, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronic devices, it has recently also been recognized as a photonic material for novel optoelectronic applications. Surprisingly, little attention has been devoted to graphene-based nanophotonic applications where optical fields are confined far below the diffraction limit. Due to its ultrasmall thickness and extremely high purity, it supports extremely strong wave localization at the nanoscale (also identified as surface plasmons) with relatively low losses. Moreover, graphene can be tuned from a semiconductor to a metal simply by applying a gate voltage, holding promise for in-situ tuneability of strong light-matter interactions at a length scale far below the wavelength. This makes graphene the ideal material to synergize nano-optics and electronics at the nanoscale. This research will demonstrate the application of graphene as a novel nano-photonic material that outperforms greatly existing photonic materials (cavities and metals). We will engineer ultra-strong and coherent light-matter interactions between single emitters and graphene, and implement several quantum electrodynamics (QED) applications. This research will address fundamentally new phenomena associated to the peculiar properties of graphene, while the development of this novel type of integrated nano-optoelectronic device will enable potential applications ranging from nanoscale (quantum) optical switches and quantum information processing, to super-efficient light collection, and ultra-fast and sensitive sensing of single (bio) molecules.",Graphene Nano-Photonics,FP7,31 July 2015,01 August 2011,100000.0 GRAPES,Imperial College London,information and communications technology,"Graphene has emerged as one of the most exciting materials in recent years. This interest has now spread to the field of photocatalysis, with the intention of utilizing graphene as a two-dimensional photocatalyst material, and with the potential to harness graphene’s redox properties for opening up new opportunities in next generation photocatalyst systems. The proposed project is aimed at developing new robust-light hybrid materials based on semiconductor nanoparticles-graphene, targeting the improvement of their photocatalytic activity in different supports. This project opens a new opportunity to solve a wide number of environmentally problems as wastewater and air pollutants treatments, or sustainable solar fuel as the photocatalytic splitting of water to obtain hydrogen.",GRaphene Enhancement of the Photocatalytic Activity of Semiconductors,FP7,11 June 2017,12 January 2013,221606.4 GRAPH-CNTS-CAT,Rijksuniversiteit Groningen * University of Groningen,information and communications technology,"The objective of this proposal is the synthesis of a new type of carbon-based catalyst for application in heterogeneous catalysis: defect free graphene as well as graphene oxide will be produced and sandwiched with carbon nanotubes through layer-by-layer deposition and intercalation chemistry to yield novel pillared carbon nanotube-graphene structures. Using intercalation chemistry metal atoms and ions will be inserted into their pores to achieve high catalytic turnover and selectivity towards a substrate could lead to an innovative “green” technology for pollution control. These materials will be characterized by Raman and XPS spectroscopies. Structural/morphological studies will allow investigations from the long range (XRD) to the short range (SEM, TEM) and thus the study the pillared carbon nanotube-graphene structures on different scale lengths, from meso- to nano-scale, before and after metal intercalation. Their catalytic activity will be evaluated using simple hydrogenation reactions of olefins in gas and liquid phases. The fellow will enlarge her experience on materials in environmental physical chemistry. She will built on her work with natural oxides and clays, which involved (a)synthesis and characterization of materials (b)study of surface/interfacial physicochemical properties and (c)catalysis. In a multidisciplinary training based on a state-of -the art infrastructure and guided by a world specialist in carbon materials, she will acquire new knowledge on physical deposition and characterization techniques. She will strengthen her soft skills by training in project management, presentation techniques, grant writing and IP issues. By being inserted in the broad international network of collaborations of her host group she will be able to build up her own future set of connections. All together this project will give the fellow all the tools for fulfilling her dream of a successful independent future career in academic research.",Intercalated Graphene Carbon Nanotubes for Heterogeneous Catalysis,FP7,11 February 2012,11 March 2011,82124.4 GRAPH-COUPL,Cardiff University,photonics,"The analysis of thin branched structures has become very popular in Mathematical Physics during recent years. One reason is the increasing technological feasability of manufacturing nano-structures at an atomic level, making a detailed quantum mechanical analysis of the problem necessary. Thin branched structures occur e.g. in micro-electronics or in opto-electronics; and a theoretical analysis is necessary in order to understand the behaviour of such media or to engeneer materials with certain properties. One is for example interested whether a material conducts or transmits light or not, e.g. semi-conductors or photonic crystals. The project aims in a mathematical analysis of thin branched structures providing a large class of (at least approximatively) solvable models. One goal of the project is to what extend thin branched structures can be understood by their decomposition into simple building blocks according to the underlying network structure. By this decoupling method, we want to tackle open problems in Mathematical Physics like the extended states conjecture, i.e., the question whether a randomly perturbed periodic medium still allows transport for small perturbations. Another goal of the project is the question whether thin branched structures and their properties can approximately be described by the pure one-dimenional limit, the underlying network structure. Olaf Post, the researcher of the proposal, is an expert on the theory of thin branched structures in the zero-thickness limit. Marco Marletta, the scientist in charge, is a recognized top-level specialist in the mathematical analysis of partial differential operators and their spectral properties and in operator theory. Our project brings together these two very active areas of Mathematics, and aims in providing concrete mathematical models which are useful in engineering nano-structure devices.",Spectral analysis of graph-coupled systems,FP7,31 December 2012,01 January 2012,132968.0 GRAPHENE-CA,Chalmers University of Technology * Chalmers Tekniska Högskola,photonics,"This Coordination Action aims to prepare a European Flagship project focussed on 'Graphene-Driven Revolutions in ICT and Beyond' (GRAPHENE). The overwhelming current focus on graphene, discovered by A.K. Geim and K. Novoselov in 2004, is driven by the considerable and tantalizing potential that this material offers in conventional as well as radically new fields of ICT applications. Europe can play a key role in future graphene-based ICTs provided a long term strategy of transferring knowledge and intellectual property to technological applications is carried out in a coordinated, effective and organized fashion. GRAPHENE-CA will establish a comprehensive scientific and technological roadmap, by taking advantage of the activities of an existing nanoICT graphene working group, contributions of selected industrial partners and key scientists such as the Nobel Laureates A.K. Geim, K. Novoselov, A. Fert and K. von Klitzing. This roadmap will be the basis to develop the research agenda for the subsequent GRAPHENE flagship, which will cover electronics, spintronics, photonics, plasmonics and mechanics based on graphene, and supporting areas such as graphene production and graphene chemistry. The CA will frame the development of a graphene flagship that is aimed to serve as a sustainable incubator of new branches of ICTs applications, rooted on European scientific excellence and interdisciplinarity (merging physics and chemistry with engineering communities), and providing Europe a strategic instrument and infrastructure for innovation in ICT-related science and applications.",Coordination Action for Graphene-Driven Revolutions in ICT and Beyond,FP7,30 April 2012,01 May 2011,1355000.0 GRAPHENEGASSENSORS,University of Manchester,information and communications technology,"Goal of the proposed research is to transfer the knowledge of experienced researcher to Europe. Detection of minor gas leaks in a hazardous work environment has been a challenging research problem for many decades as it involves health, safety and environmental risks. In this proposed research we will develop graphene based gas sensors with ultrafast response, high sensitivity, great selectivity and high durability to detect the environmental pollutants even in very low concentrations. We intend to target the detection of various toxic gases such as CO2, CO, H2S, NOx, ethanol, and SO2 in ppb level. Graphene is relatively a new material to be used for practical sensor purpose. The idea underlying the selection of graphene for sensor application is its variable conductivity, which makes it available for electron transport phenomena with very high electrical mobility in the presence of oxidizing and reducing gases. The feature of high conductivity will be exploited by using graphene as conductivity-based chemical gas sensors. The proposed study will allow the optimization of sensor parameters for making sensors with good selectivity for target gases by using metal catalyst such as Pt, Pd, and Au on the surface of graphene. The idea underlying the present proposal is that by coating graphene with metal nanoparticles, one could increase the effective surface area and modify the work functions, thereby improving the sensitivity and selectivity of the gas sensors. Successful completion of this research will have enormous benefit to European society through numerous applications, including the reduction of health risks and improvement of public security, detection of environmental toxins and semiconductor processing. Researcher Dr. Rakesh K. Joshi is expert in nanomaterials synthesis and sensor development while Prof. Andre Geim is the discoverer of graphene and its sensor application. Both researchers have worked extensively in graphene and gas sensors.",Graphene-Based Ultra-Sensitive Gas Sensors,FP7,06 September 2013,06 October 2011,280680.0 GRAPHENETHIOPHENE,Stichting Katholieke Universiteit * Catholic University Foundation,information and communications technology,"Diamond and graphite, the two well-known allotropes of carbon, were familiar from the ancient times. Fullerenes, the third form of carbon, were discovered in 1985 and carbon nanotubes in 1991. Thus three dimensional (3D) (diamond and graphite), 1D (nanotubes) and 0D (fullerenes) allotropes were known. Since the breakthrough in 2004 that two dimensional allotropes of carbon, graphene has been reported. It can be used in molecular electronics applications, such as field-effect transistors, research into this novel material has exploded. Graphene, a single sheet of graphite, consists of a hexagonal array of sp2-hybridised carbon atoms. The material has excellent electrical properties, is cheap to make and requires no helicity control, giving it a definitive advantage over other carbon-based materials such as nanotubes. In addition, the electronic properties of graphene sheets can be influenced by introducing atomic defects, using programmed self-assembly, and by changing the charge carrier concentration in bilayer graphene. Unfortunately though, the conductivity as of yet cannot be switched off, which impedes its incorporation into switchable systems. Recently, the poor material properties of the graphene were improved considerably by dispersing the single carbon sheets inside a polymer matrix, providing a path to a broad class of conductive composite graphene-based materials. The construction of small graphene sheets by chemical synthesis has recently been reported by Müllen. This bottom-up chemical synthesis of such large, unsaturated polycyclic aromatic hydrocarbon surfaces, however, has proven very laborious and time consuming, requiring a huge synthetic effort. Therefore, the aim of this proposal is the construction and physical characterisation of a novel class of materials which closely resemble graphene, by facile chemical synthesis, which can be synthetically tailored and post-processed to tune the material properties: clickgraphene.",Novel kind of graphene based materials and its blend with polythiophenes,FP7,11 June 2012,11 July 2010,167697.15 GRAPHENOCHEM,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,energy,"We propose the development of modern wet chemical concepts for the mass production and chemical modification of graphene - a rapidly rising star on the horizon of materials science - opening the door for superior but still elusive applications such as transparent electrodes, field effect transistors, solar cells, gas sensors and polymer enforcement. Owing to its spectacular electronic properties graphene is expected to be the most promising candidate to replace classical Si-technology and no longer requires any further proof of its importance in terms of fundamental physics. However, fully exploiting the proposed applications requires the availability of processable graphene in large quantities, which generally has been considered to be an insurmountable challenge. This is where the GRAPHENOCHEM project sets in. Our laboratory has been pioneering and is at the forefront of carbon allotrope chemistry. After having investigated basic principles for the functionalization of the 0-dimensional fullerenes and the 1-dimensional carbon nanotubes, which lead to synthesis of numerous examples of derivatives with tailor made properties, we recently started successfully with the investigation of wet chemical approaches for the efficient production of graphene sheets using graphite as an inexpensive starting material. The strategy of GRAPHENOCHEM is to combine chemistry, nanotechnology and materials science to establish highly efficient protocols for the mass production of soluble graphene and the subsequent processing to a whole variety of thins films, composites and devices with outstanding properties. To our knowledge we are the first synthetic organic chemists facing this challenge. We propose to go through the following sequential key objectives, namely: Development of efficient protocols for the mass production of soluble single layer graphene, cloning of graphene, chemical functionalization and doping of graphene, and engineering of graphene based materials and devices.","Large Scale Production, Cloning, Chemical Functionalization and Materials Applications of Graphene",FP7,31 January 2015,01 February 2010,1436400.0 GRAPHITE4MED,Christian-Albrechts University of Kiel * Christian-Albrechts-Universität zu Kiel,health,"We propose an interdisciplinary project with the objective to explore the feasibility of aerographite as scaffold material for tissue engineering in regenerative medicine with special focus on directed cell growth. Aerographite is a novel carbon based material that consists of a seamless interconnected network of microtubes. The project is motivated by promising developments of related carbon materials (carbon nanotubes and graphene) in biomedical applications. Aerographite is a potential candidate for tissue engineering, as it can be fabricated in a highly controllable manner to create various macroscopic 3-D shapes. Tailored microarchitectures can be realized that offer penetrability and accessibility of surfaces. These features are key factors for 3-D tissue growth. The 2-year project will be realized in three stages: 1. Material characterization and chemical surface modification to impart aqueous compatibility, 2. Biofunctionalization for specific cell adhesion, and 3. Quantification of cell adhesion and growth on functionalized scaffolds. All tasks are highly interdisciplinary and combine aspects of materials science, chemistry, biology and biophysics and medicine as evident in the variety of analytical techniques that will be employed. Aerographite structures and their functionalization will be investigates with Raman spectroscopy, scanning electron microscopy (SEM), scanning probe microscopy (SPM), and contact angle measurements. SPM, confocal fluorescence microscopy and environmental SEM will be used to assess cell growth on aerographite. Biological assays will be applied to evaluate biocompatibility and cytotoxicity. For the success of the project the applicant can profit from her previous collaborations with European research groups and the excellent research environment at the host university. New collaborations and acquisition of new skills and knowledge will complement her scientific profile and enable her to start a junior group in the near future",Aerographite as scaffold material for regenerative medicine,FP7,31 March 2015,01 April 2013,161968.0 GRASP,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Finding an approach to actuate nonlinear optical effects at ultra-low powers and on chip-scale devices is one of the outstanding challenges in optics. The ultimate limit is the quantum regime where individual light quanta strongly interact with each other. This limit has so far been technologically impossible, but if achieved would have far-reaching consequences in information technologies. In particular, it would enable the best possible performance and wide deployment of classical nonlinear devices, and facilitate disruptive quantum information protocols that fundamentally cannot be realized on classical platforms. The primary obstacle is the weak nonlinear response of available optical materials, which necessitates high intensities and long interaction times to induce nonlinear effects.In this proposal, we will theoretically and experimentally pursue a fundamentally new paradigm -graphene-based single-photon nonlinear optics -that eliminates all of the current barriers. Our approach builds upon remarkable properties of graphene, which cause surface plasmons to be confined to scales millions of times smaller than the diffraction limit, and also induce exceptional nonlinear interaction strengths. We will show that in this unconventional nonlinear medium, even single quanta attain the requisite intensities to actuate nonlinear processes. Significantly, we aim for the first demonstration of the deterministic generation of non-classical light, which is based on 'bulk' nonlinear materials rather than individual quantum emitters.The partners of GRASP are internationally recognized in the fields of graphene, nano-photonics, quantum optics, and quantum information science, and have a strong history of launching innovative multi-disciplinary research directions. This team is uniquely suited to establish graphene as the first viable route to widely deployable, chip-scale classical and quantum nonlinear optical technologies.",GRAPHENE-BASED SINGLE-PHOTON NONLINEAR OPTICAL DEVICES,FP7,31 December 2016,01 January 2014,2003851.0 GREAT,University of Strasbourg * Universitè de Strasbourg,health,"GREAT aims at offering to a young scientist with an excellent scientific record, possessing a Ph.D in chemistry, a cross-disciplinary and supra-sectorial training and research experience in the emerging field at the interface between physics, materials sciences, supramolecular chemistry, electrical engineering and nanoscience with the ultimate goal of offering him an education in a new field of research and broadening his skills in science and complementary subjects. The overall mission is to train the young researcher to become an independent scientist as well as to prepare him for a leading position in academia or industry. Within GREAT the training-through-research is targeted at exploiting tailor-made graphene organic based systems to study their structure and electronic properties and ultimately to assess their potential in photovoltaic applications and more generally in (opto)electronic devices. Understanding and bottom-up tuning of graphene properties is essential for its potential optoelectronic applications since organic-derivatized graphenes show improved conductivity, charge mobility and mechanical strength. To accomplish this goal, we will combine bottom-up and top-down approaches: graphene-hybrid materials prepared by either covalent modification or by supramolecular functionalization of graphene with functional molecules in a given liquid media will be self-assembled forming multicomponent architectures with a high degree of order at multiple length scales, i.e. from the nano to the macroscopic scale. These architectures will be employed as semiconducting layers in field effect transistors (FETs) and solar cells (SC's), or as transparent electrodes as alternative to ITO electrodes. Prototype of devices will be fabricated in order to investigate in depth and in a broader context two fundamental physical properties for optoelectronics, i.e. charge injection and charge transport characteristics.",GRaphene supramolEculAr elecTronics: a life-long training Career development project,FP7,28 February 2014,01 March 2012,193594.0 GREEN NANO-MESH,National University of Ireland Galway,health,"Hernia operations are among the most common surgical procedures performed today with over 20 million cases annually worldwide. Hernia incidents are associated with pain and poor quality-of-life for the patient and lead to enormous healthcare costs, exceeding US $48 billion in the US annually. At present, hernia operations rely heavily on non-degradable polypropylene, polytetrafluoroethylene and nylon meshes. However, these polymers are often associated with foreign body reaction; implant failure; and hernia reoccurrence (over 42%). Moreover, leaking chemicals of these polymers are often deleterious to the surrounding cells and tissue and immobilise post-operative drug treatments. In addition, the process technologies are often associated with environmental risks. Herein, we propose a novel approach that employs recent advances in green nanotechnology and sustainable raw materials for scaffold fabrication that not only will eliminate toxic chemicals from the processes, but will also enhance functional repair due to superior biological properties. Specifically, we aim to fabricate a nano-fibrous mesh with well-defined nano-topography using cellulose; human recombinant collagen, derived from transgenic tobacco plants; and biodegradable polylactic/polyglycolic acid as raw materials. The green credentials of this innovative approach lie in the use of sustainable eco-friendly raw materials that will produce biodegradable waste products and therefore replacing hazardous chemicals currently in use. Thus, this proposal directly fits the call for the substitution of materials or components with 'green nano-technology'.",Targeting Hernia Operation Using Sustainable Resources and Green Nanotechnologies. An Integrated Pan-European Approach,FP7,31 May 2015,01 June 2011,2692666.0 GREEN SILICON,University of Glasgow,energy,"The primary objective of this project is to demonstrate integrated on-chip thermoelectric energy harvesting using micro-/nano-fabricated Si/SiGe nanostructures with improved efficiencies through the use of band-structure and phonon engineering. High performance thermoelectric materials require high electrical conductivity and low thermal conductivity. Our approach is to engineer thermoelectric materials which enhance the electrical conductivity while simultaneously blocking the tranport of thermal energy through the devices. Bulk 2D Si/SiGe superlattices, laterally patterned 1D nanowires and 0D quantum dots made from Si/SiGe heterostructure technology will be investigated for high performance thermoelectrics in microsystems and other applications. We propose to combine the optimum 2D superlattice or 0D quantum dot material with 1D nanowire patterning to further improve the thermoelectric performance of microgenerators. The final optimised thermoelectric generator will be integrated with a capacitor energy store on a mm-sized single silicon chip to demonstrate a power source for an autonomous system. This will be used to power a micropower CMOS sensor to demonstrate its use as an energy harvesting system. The developed technology will be compatible with the power supply requirements for wireless autonomous systems such as those defined in the IEEE 802.15.4 standard. While the project is aimed at on-chip sustainable energy generation, the techniques, technology and IP being developed will also be able to be deployed into high efficiency (>20%) thermoelectric generators and Peltier coolers for domestic and industrial applications.",Generate Renewable Energy Efficiently using Nanofabricated Silicon,FP7,31 July 2013,01 August 2010,1660000.0 GREENANOFILMS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"Carbohydrate biomass constitutes an abundant and renewable resource that is attracting growing interest as a biomaterial. Convincingly the use of different natural 'elementary bricks', from oligosaccharides to fibers found in biomass, when mimicking self-assembly as Nature does, is a promising field towards innovative nanostructured biomaterials, leading to eco-friendly manufacturing processes of various devices. Indeed, the self-assembly at the nanoscale level of plant-based materials, via an elegant bottom-up approach, allows reaching very high-resolution patterning (sub-10nm) never attained to date by petroleum-based molecules, thus providing them with novel properties. GREENANOFILMS aims to use carbohydrates as 'elementary bricks' (glycopolymers, cellulose nanocrystals and nanofibers) for the conception of ultra-high resolution nanostructured technical films to be used in various markets, from large volume sectors, such as (i) high-added value transparent flexible substrate for printed electronic applications, (ii) thin films for high-efficiency organic photovoltaics, to growing markets, such as (iii) next generation nanolithography and (iv) high-sensitivity SERS biosensors. GREENANOFILMS main impacts are the implementation of a new generation of ultra-nanostructured carbohydrate-materials that will play a prominent role in the achievement of the sustainability improvement of various opto- and bio-electronic sectors. A network of industrial end-user leaders is integrated in the project to facilitate the innovator-to-market perspective. The prospective environmental impacts and benefits of new green processes, eco-efficient nanomaterials and nanoproducts will be quantified with Life Cycle Assessment, risk assessment and validation of the industrial feasibility, including economic evaluation of the products. The results will be disseminated to the European smart paper, printed electronic, photovoltaic, display, security and health communities.",Development and application of ultra-high resolution nano-organized films by self-assembly of plant-based materials for next generation opto- and bio-electronics,FP7,31 January 2017,01 February 2014,3815856.0 GREENBAT,VARTA Microbattery GmbH,energy,"In this project printed thin film batteries (TFBs) are developed, manufactured and integrated as flexible and cost efficient energy storage devices. This kind of energy storage concept has huge potential to be integrated into different low cost large area electronics applications such as smart cards, E-books, tags, large area sensor networks… In order to reduce manufacturing costs of this application field the TFBs fabrication is transferred to a roll to roll mass production process which enables cost efficient and large area processing on new or traditional substrates (plastic, glass, paper..). Thus, new nano materials are integrated as batteries components through conventional printing processes (Flexo/helio and Screen printing) used in the industry. So far printed TFBs have been studied to be manufactured using commercially available materials. The goal of GREENBAT project is to integrate new generation of advanced smart materials in thin film printable batteries using aqueous formulation to achieve high quality, green, safe and durable power sources. The ultimate goal of this project is to integrate these structures to a single assembly resulting in a flexible energy source processed in one step thus reducing production cost. The effort of the GREENBAT consortium is to create a new technology environmental friendly, safe and durable which enables European Community to be competitive with the Asia products, in order to address the area of low cost power source manufacturing and its utilisation in different applications. The competitiveness of European industry in this new disruptive technology has much more potential than in well established products. The development in GREENBAT project creates synergies and cooperation between micro nano technologies RandD, power sources manufacturers, printing industries and end users.",GREEN and SAFE thin film BATteries for flexible cost efficient energy storage,FP7,30 September 2011,01 June 2008,2799319.0 GRENADA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"The semiconductor industry has been able to improve the performance of electronic system by making ever-smaller devices. However, this approach will soon encounter both scientific and technical limits, which is why the industry is exploring alternative device technologies. Carbon-based nano-electronic is currently investigated. Discovered recently, the graphene is rapidly raising star on the horizon of materials science and condensed-matter physics. Its exceptional properties make it a promising material for applications in future nanoelectronic circuits and a number of graphene based devices have been proposed theoretically or already tested. However, the current performances are still below that what expected from this magic layer. Indeed, the alternative graphene synthesis, its manipulation and its interaction with neighboring environment impact drastically its structural properties considering intrinsic or generated defects. In this context, the key objective of GRENADA proposal is to tailor the graphene’s properties and morphologies to provide high quality layers through different scalable deposition technologies. GRENADA consortium will work on graphene material development and properties investigation that be used as a final point in proof concept by operating basic systems to measure the graphene performances. Prior to that, a strong focus will be made on defects that are crucial regarding graphene properties and they will be, then, considered through their formation, evolution and their specific impact on integrated graphene properties. The consortium includes internationally renowned experimental and theoretical groups from academic and industry in advanced elaboration, modelling, characterization and industrialization methods that have a significant potential for graphene nanomaterials. That will ensure a tight focus on the exploitation of the project results for European industry.",GRaphenE for NAnoscaleD Applications,FP7,12 July 2015,01 January 2011,3445370.0 GRINDOOR,Uppsala University * Uppsala Universitet,construction,"The GRINDOOR project aims at developing and implementing new materials that enable huge energy savings in buildings and improve the quality of the indoor environment. About 40% of the primary energy, and 70% of the electricity, is used in buildings, and therefore the outcome of this project can have an impact on the long-term energy demand in the EU and the World. It is a highly focused study on new nanomaterials based on some transition metal oxides, which are used for four interrelated applications related to indoor lighting and indoor air: (i) electrochromic coatings are integrated in devices and used in “smart windows†to regulate the inflow of visible light and solar energy in order to minimize air condition and create indoor comfort, (ii) thermochromic nanoparticulate coatings are used on windows to provide large temperature-dependent control of the inflow of infrared solar radiation (in stand-alone cases as well as in conjunction with electrochromics), (iii) oxide-based gas sensors are used to measure indoor air quality especially with regard to formaldehyde, and (iv) photocatalytic coatings are used for indoor air cleaning. The investigated materials have many things in common and a joint and focused study, such as the one proposed here, will generate important new knowledge that can be transferred between the various sub-projects. The new oxide materials are prepared by advanced reactive gas deposition—using unique equipment—and high-pressure reactive dc magnetron sputtering. The materials are characterized and investigated by a wide range of state-of-the-art techniques.",Green Nanotechnology for the Indoor Environment,FP7,05 July 2018,06 January 2011,2328726.0 GRNES,The University of Edinburgh,health,"Self-renewal of embryonic stem (ES) cells depends on the activity of a network of transcription factors at the centre of which lies the triumvirate of Nanog, Oct4 and Sox2 that bind together to a multitude of target genes to either activate or repress their expression. Nanog was initially isolated by the host laboratory on the basis that elevating its expression increased ES cell self-renewal efficiency. Surprisingly however, the host laboratory further demonstrated that ES cells continue to self-renew in the absence of Nanog, albeit with dramatically reduced efficiency. Moreover, Nanog is not expressed uniformly within the Oct4/Sox2-expressing undifferentiated population. Instead, ES cells fluctuate between a state in which Nanog protein levels are low or absent, associated with a poor self-renewal efficiency, and a state in which Nanog levels are high, associated with a high self-renewal efficiency. In order to shed light upon the means by which these fluctuations direct altered cellular functions, we propose a project with the specific aims of: (i) determining the gene expression profile in ES cells expressing distinct forms of Nanog, (ii) analysing the co-dependency of chromatin binding by Nanog, Oct4 and Sox2 at relevant target genes, and (iii) test the functional importance of the most relevant Nanog responsiveness genes.",Analysis of the gene regulatory network controlling ES cell identity,FP7,31 August 2012,01 September 2010,181103.0 GRYPHON,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"Infrared spectroscopy is a powerful technique for bio-chemical analyses and an essential sensing tool in medicine, biology, chemistry, pharmacy and many other disciplines and industries. Surface-enhancing techniques use noble metal nano-structures to induce high field-enhancement and improve the sensitivity of these systems and sensors. Important improvements have been achieved with the optimization of these nano-structures, but it is now clear that enabling a new significant step in performance will require the exploration of new approaches, beyond the mere geometrical optimization of noble metal particles and arrays. This project proposes to use graphene as a new enabling material to improve the sensitivity and versatility of infrared spectroscopy systems and sensors. Beyond the trend to study graphene for virtually any application to determine its potential, current state of research in graphene plasmonics already demonstrates outstanding potential for spectroscopy. Still, the unique electromagnetic properties of graphene have not yet been exploited for surfaced-enhanced infrared absorption. Indeed, graphene nano-structures have the potential to surpass its noble metal counterparts in several aspects. Graphene-based resonators can potentially achieve higher Q-factors than those provided by metal resonators, which in turn would lead to enhanced sensitivities. High Q-factor graphene resonators can be then used for enhanced sensing through new approaches, for instance by taking advantage of the graphene conductivity variation due to analyte-induced doping. New capabilities arise also from the electrostatic tunability of graphene conductivity, which can provide additional capabilities such as wavelength-scanning and spatial-scanning. In summary, graphene-based plasmon-enhanced infrared systems have the potential to reach a versatility degree, sensitivity levels and additional capabilities, that clearly surpass those of current IR surface-enhanced systems.",Tunable Graphene Nanostructures for Plasmon-Enhanced Infrared Spectroscopy,FP7,31 March 2016,01 April 2014,199317.0 GSL IN DEVELOPMENT,Pasteur Institute * Institut Pasteur,health,"Glycosphingolipids have been implicated in the development of various human pathologies, such as cancer, obesity, diabetes or Alzheimer diseases. Their wide implication in cellular membrane architecture and cellular signaling network and metabolism has however made difficult the establishment of an integrated and accurate understanding of their role in vivo. The current proposal aims to understand such a role by taking advantage of a highly versatile system model, the Drosophila melanogaster. By combining sophisticated genetic and biochemical approaches with cutting edge biophysical strategies, such as FRET or FRAP technologies, this proposal intends to 1) determine how GSLs affect the dynamic organization of membranes at the nanoscale resolution in vivo, 2) study the GSL impact on cellular signaling and 3) polarity and finally 4) uncover some putative molecular regulators of GSL function in vivo. Preliminary work in Drosophila embryos allowed us to demonstrate that the absence of core GSLs in two related lethal mutants, egghead (egh) and brainiac (brn), leads to a surprisingly specific phenotype consisting in an increased number of proprioceptive organs. During the eclosion process, flies lacking core GSLs are unable to organize their movements and dies within the pupae case. Interestingly, Brn protein expression in brn flies using the UAS/GAL4 system in proprioception organs rescues their phenotype. We hence intend to take advantage of these rescue conditions to screen for molecular factors allowing to compensate the absence of core GSLs. Finally, the increased in proprioceptive organs being typically associated to an upregulation of the EGFR pathway, we aim to understand its genetic relationship of brn and egh mutations. This comprehensive characterization of the role of core GSLs in vivo will certainly constitute an important step in order to further evaluate the nature of their function in Drosophila models of human diseases in the near future.",The role of glycosphingolipids in development,FP7,30 September 2013,01 March 2011,62500.0 GTNCTV,University of Sheffield,health,"Targeting therapeutic genes selectively into the central nervous system (CNS) is a crucial precondition for translation of gene therapy strategies into human trials. The current multidisciplinary proposal integrates expertise identified as essential in the effective acceleration of research to overcome bottlenecks in the field including: 1) Inefficiency of therapy delivery to the CNS because of factors like the blood-brain barrier (BBB); 2) Poor understanding of disease mechanisms at the molecular and cellular levels. These problems must be overcome to develop fully effective treatments for neurological disorders. Currently the adeno-associated (AAV)-based system is one of the most refined and effective gene delivery systems for neuronal cells. In contrast to all other systems, it has been possible to engineer AAV9 to deliver genes through the BBB to the CNS by intravascular (IV) administration. However, following IV delivery, these vectors also target liver and other tissues, with significant potential for untoward effects. This has prompted us to adopt two major strategies: i) targeting of AAV9 vectors at the level of transcription by insertion of hybrid motor neuron specific promoters into the vector genome; ii) development of a CNS-targeted delivery approach based on state-of-the art nanoparticle-mediated encapsulation of AAV9 vectors. We anticipate that engineering strategies with the ability to restrict transgene expression to CNS tissue will significantly overcome various existing hurdles in CNS gene therapy development. Our objectives are to: 1) explore mechanisms leading to penetration of scAAV9 vectors through BBB since the exact mechanism of AAV9 diffusion through BBB is unknown; 2) design novel targeted strategies with enhanced tropism to CNS; 3) use CNS targeted vectors to investigate mechanisms of motor neuron death linked to mutations in RNA processing genes; 4) utilise CNS-targeted systems to test therapeutic strategies for motor neuron diseases.",Gene therapy and nanotechnology based CNS targeted vectors,FP7,28 February 2017,01 March 2012,2499958.0 GUIDEDNW,Weizmann Institute of Science,energy,"The large-scale assembly of nanowires (NWs) with controlled orientation on surfaces remains one challenge toward their integration into practical devices. A recent paper in Science from the PI's group reported the guided growth of millimeter-long horizontal NWs with controlled orientations on crystal surfaces. The growth directions and crystallographic orientation of GaN NWs are controlled by their epitaxial relationship with different planes of sapphire, as well as by a graphoepitaxial effect that guides their growth along surface steps and grooves. Despite their interaction with the surface, these horizontally grown NWs have surprisingly few defects, exhibiting optical and electronic properties superior to those of vertically grown NWs. We observed that whereas in a 2D film stress accumulates in two directions, in a NW stress accumulates along its axis, but can relax in the transversal direction, making the 1D system much more tolerant to mismatch than a 2D film. This new 1D nanoscale effect, along with the graphoepitaxial effect, subverts the paradigm not only in the young field of NWs, but also in the established field of epitaxy. This paves the way to highly controlled semiconductor structures with potential applications not available by other means. The aim of this project is to investigate the guided growth of NWs and unleash its vast possibilities toward the realization of self-integrating nanosystems. First, we will generalize the guided growth of NWs to a variety of semiconductors and substrates, and produce ordered arrays of NWs with coherently modulated composition and doping. Second, we will conduct fundamental studies to investigate the correlated structure, growth mechanism, optical and electronic properties of guided NWs. Third, we will exploit the guided growth of NWs for the production of various functional self-integrating systems, including nanocircuits, LEDs, lasers, photovoltaic cells, photodetectors, photonic and nonlinear optical devices.",Guided Nanowires: From Growth Mechanism to Self-Integrating Nanosystems,FP7,31 January 2019,01 February 2014,2063872.0 GUIDENANO,Acondicionamiento Tarrasense Associacion,environment,"The main objective of GUIDEnano is to develop innovative methodologies to evaluate and manage human and environmental health risks of nano-enabled products, considering the whole product life cycle. A strategy to identify hot spots for release of nanomaterials (NMs) will be followed by decision trees to guide on the use of (computational) exposure models and, when necessary, design of cost-effective strategies for experimental exposure assessment. These will include on-site and off-site monitoring of industrial processes, use, accelerated aging, recycling and disposal set-ups. In all cases, there will be a strong emphasis on the transformation of NMs. Similarly, a tiered strategy to evaluate the environmental fate and the hazards for ecosystem and human health of NMs will be developed. The project will consider pristine synthesized NMs, transformed NMs released during the life cycle of the product, and interactions of the NMs with other substances in their host matrices and ubiquitous pollutants. The project will also develop innovative solutions to reduce identified risks. These will include safer-by-design approaches (to reduce NM hazard, reduce migration and release, or accelerate degradation when released), new technological solutions for exposure control measures, and solutions for waste minimization and treatment.",Assessment and mitigation of nano-enabled product risks on human and environmental health: Development of new strategies and creation of a digital guidance tool for nanotech industries,FP7,04 June 2019,11 January 2013,0.0 GUVS-3G,Complutense University of Madrid * Universidad Complutense de Madrid,health,"Giant lipid vesicles can be potentially used as biocompatible carriers with a large lumen cavity adequate for lodging large biomacromolecules in an aqueous compartment. New developments in controlled delivery are strongly troubled by the high polydispersity of the preparations and the limitations in the encapsulation abilities inherent to conventional preparative methods. Engineering smart vesicles with tunable and remotely controllable properties such as permeability, osmotic deformability or inducible instability, necessary for adequate delivery, is indeed a major synthetic challenge. This implies a number of basic operations, which include bilayer assembly, composite membrane stabilization, encapsulation and compartmentalization, a set of procedures requiring a novel approach. For this performance, we propose the use of microfluidic technology and high-speed imagining to design and study the active response to photo-irradiation of smart giant unilamellar lipid vesicles with plasmonic gold nanoparticles embedded in the membrane. Excitation of the surface plasmons of the nanoparticles produces localized heating of the membrane, thus controllable changes in permeability, which could eventually result in an enhanced osmotic-driven flow of solvent across the membrane and cause an overall change in size and shape of the entire vesicle. Using these model systems we will be able to shed light on the physical mechanisms involved in the transference of conformational- to mechanical- energy, which could be relevant to a broad range of scientific problems ranging from the fundamental knowledge in cell biology, concerned by the study of cellular functions such as endo- and exocytosis and cell motility, to applications in drug delivery and material engineering, both enrolled in the development of hybrid materials able to exert nastic motions inducible by external stimuli.",Smart photo-activable devices based in plasmonic nanoparticles: Microfluidic-assisted engineering of a third generation of lipid vesicles,FP7,21 December 2016,01 September 2013,254925.0 HABER,Imperial College London,health,"The aim of the proposed project is to produce a new generation of hybrid materials that heal bone defects, reduce the need for transplants, improving quality of life for trauma and cancer patients and the elderly. The new materials will share load with bone, stimulate bone growth and dissolve after the bone is repaired. They will also be able to be cut to shape by a surgeon in theatre. Current bionert implants have a limited lifespan, which is a major problem for traditional materials as human life expectancy continues to increase. Therefore, this project aims to shift emphasis from replacement of tissues to regeneration of tissues to their original state and function. In this proposal new bioactive organic-inorganic hybrids will be created that could, for the first time, fulfil all the criteria for an ideal scaffold. Hybrids are a new way to obtain synergy from materials, where the organic is introduced while the inorganic network is being assembled so that the components interact at the molecular level. The key to success is using polymers that have not yet been exploited for construction of bone scaffolding materials. This is because the degradable polymers that are currently approved for biomedical applications (e.g. polyesters) degrade and lose their mechanical properties too rapidly once degradation begins. Alternatives are naturally occurring polymers that are enzyme degradable and can therefore degrade by natural remodeling mechanisms after implantation. Also key is obtaining controlled covalent bonding between the organic and inorganic components. In addition nanoscale texture will be introduced on the scaffolds surface by the incorporation of polyhedral oligomeric silsesquioxanes nanostructures, which are non toxic, biocompatable can promote faster osseointegration and provide in situ mechanical stability to the scaffold. In this way the proposed hybrid scaffolds will be optimized from the surface topology to the nano and macro scale.",Hybrid approaches to bone regeneration,FP7,16 September 2014,17 September 2012,209033.0 HANDY-Q,University of Bremen * Universität Bremen,photonics,"Microcavity polaritons are half-light, half-matter composite bosons, which are formed in monolithic semiconductor microcavities of the proper design. Recently, Bose-Einstein condensation of polaritons has been reported, that constitutes a new class of quantum fluid out of equilibrium. Unlike cold atoms, superfluid Helium or superconductors, polaritons are in a driven-dissipative situation, and their mass amounts only to a negligible fraction of an electrons'. This unusual situation has already revealed very interesting phenomena. Moreover, every observables of the polariton fluid, including momentum, energy spectrum and coherence properties are directly accessed via optical spectroscopy experiments. In this project, we will fabricate and investigate new wide band-gap semiconductor nanostructures both capable of taking unprecedented control over the polariton environment, and capable of sustaining very hot and very dense quantum degenerate polariton fluids. Various confinement configurations - two, one and zero-dimensional -will be realized as well as advanced nanostructures based on traps and tunnel barriers. In these peculiar situations, the quantum degenerate polariton fluid will display a new and rich phenomenology. Hence, many premieres will be achieved like room temperature 1D quantum degeneracy, 1D quasi-condensate in solid-state systems, Josephson oscillations of polariton superfluids, and the fascinating Tonks-Girardeau state where strongly interacting bosons are expected to behave like fermions.",Quantum Degeneracy at Hand,FP7,31 October 2015,01 November 2010,1488307.0 HARCANA,Centre for Materials and Coastal Research * Helmholtz-Zentrum Geesthacht – Zentrum für Material- und Küstenforschung GmbH,health,"High aspect ratio carbon-based nanoparticles (nanotubes (CNT), nanofibres (CNF), and nanosheets or exfoliated graphite (CNS)) will be introduced into bulk polymers, into polymeric foams and into membranes. It is expected that such nanofillers will tremendously improve and modify the properties of these families of materials, allowing them to reach new markets. However, a common and fundamental problem in polymer-based nanocomposites is the large extent of agglomeration of the nanoparticles due to their high surface to volume ratio. Therefore, techniques to control deagglomeration and possibly further organization of these high aspect ratio nanoparticles in polymeric materials remain a challenge. This project under industrial leadership will therefore aim at mastering, at the nanometric and mesoscale level, the spatial organization of carbon-based nanoparticles (CNP) with various surface functionalities, sizes and shapes having large aspect ratios in bulk, foamed and thin film (membranes) polymers by using industrially viable processes. More precisely, the aim of this proposal consists in generating polymer-based nanocomposites with a percolating nanoparticle structure that is reinforcing the material and imparts it with improved electrical and thermal conductivity at a minimum of nanoparticle loading. To reach such radically improved properties, it is important to take into account that a complete dispersion is not useful and will lead to lower properties. In order to control this CNP organization within the polymer matrix, a large set of techniques will be used. They range from synthetic approaches ('grafting from', 'grafting to', 'grafting through', emulsion polymerization) to (reactive) melt or solution blending processes, and to preparation in supercritical CO2. The aim is to generate new classes of engineering materials for various applications like EMI shielding, antistatic packaging materials and membranes, as well as scaffolds for tissue engineering.",High Aspect Ratio Carbon-based Nanocomposites,FP7,30 June 2012,01 July 2008,5442052.0 HARDALT,Brunel University,manufacturing,"The total annual estimated direct cost of corrosion, not including wear damage, in the worlds is estimated at about 3.1% of the world’s Gross Domestic Product (GDP). Protective coatings serve to prevent wear and corrosion and thus reduce the total loss from corrosion and wear. Hard chromium plating is one of the most widely used techniques for production of such coatings. However, hard chromium faces many problems: EU restrictions due to use hexavalent chromium, health issues for the plating industry personnel due to cancers events, functional defects of the coatings and low current efficiency. Thus, there is an urgent need to substitute chrome plating with an alternative one that could provide the same or even enhanced benefits that chrome has, without causing the above problems.",New generation of protective coatings alternative to hard chrome,FP7,11 June 2018,12 January 2013,0.0 HARMOFIRE,Aston University,health,"Stabilized mode-locked fibre lasers (MLFLs) are important for a range of applications such as optical communications, frequency metrology, medical imaging, micro machining and femtochemistry. MLFLs are cost-efficient, easy to fabricate, have all-fibre design and high output powers. The key aims of the project are: (a) training of Mrs. Habruseva in the fast growing field of fibre lasers; and, (b) development of cost-efficient stable ultra-fast harmonic mode-locked fibre lasers (HMLFLs) for a range of applications. The interdisciplinary training includes fibre components design, fabrication, advanced modelling and implementation, polarization characterization and communication tests, where the host has a crucial expertise. Tatiana will gain additional expertise and knowledge in applications of fibre lasers, laser technologies and modelling through one-month placements at academic and industrial co-hosts. The multidisciplinary activities include supervision and teaching experience, complimentary courses on the project and knowledge management, research funding, proposal writing, and others. In the first year the Fellow will perform modelling and experimental study of HMLFLs, design and fabrication of fibre optics components, assembling of novel device for polarization control and study of HMLFLs with carbon nanotubes and nonlinear polarization evolution. During the second year the Fellow will study stabilization of HMLFLs. These studies will include research on coupled fibre lasers and development of novel methods for noise suppression. Training outcomes will broaden the Fellow's areas of expertise, enhance her leadership and organisation qualities, and hence will have a great impact on her future career as an independent researcher. Stabilized MLFLs will enable increased performance and reduced complexity of optical networks; they will benefit European community in social, research and economical aspects through contribution to communication technologies.",Harmonic Mode-locked Fibre Lasers,FP7,14 November 2014,15 November 2012,209033.0 HARMONICS-PLASMA,Imperial College London,manufacturing,"High-order harmonic generation (HHG) is an increasingly used and promising technique for achieving the extreme ultraviolet (XUV) spectral range with highest brightness, short pulse duration, and coherence. Extensive studies of this phenomenon have been mostly carried out using jets of neutral atomic gas, which have resulted in novel coherent XUV sources. However, typically observed high-order harmonics presently have the disadvantage of low conversion efficiency (10-6). This is problematic for many potential applications of HHG radiation including XUV coherent diffraction imaging, time-resolved measurements, and seeding of Free Electron Lasers. Recent studies have shown that this weakness can be partially overcome by using the ablated plasma as a nonlinear medium. An especially interesting observation, unique for harmonics originated both from gas jets, surfaces, or plasma, is the enhancement of a single harmonic, attributed to resonance with a strong radiative transition. In this way, conversion efficiencies higher than 10-5 from the pump laser radiation to the harmonics in the plateau range have been reported. The project is aimed at the enhancement of HHG efficiency from laser ablation produced on the surfaces of solid-state materials and comparison with HHG from gas jets. The milestones of the proposed investigations include (a) analysis and optimization of harmonic generation from laser plasma produced on the surface of various targets, (b) search of resonance-induced enhancement of single harmonic in the XUV range, (c) harmonic generation from the laser plumes containing nanoclusters, (d) search of the continuum in the harmonic emission near the cutoff (a characteristic signature for attosecond pulse generation), and (e) HHG from gas jets and comparison with the HHG from laser plasma. As a result of project, further improvements of the harmonic efficiency in the XUV range through the HHG from laser plasma and gas jets will be achieved.",HARMONIC GENERATION IN EXTREME ULTRAVIOLET REGION THROUGH THE INTERACTION OF SHORT LASER PULSES WITH LOW-EXCITED LASER-PRODUCED PLASMA AND GAS JETS,FP7,11 February 2012,11 March 2010,240289.6 HARNESS,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"Resonant nano-electro-mechanical systems (NEMS) have been showing outstanding performance as mass, force, charge and magnetic sensors. However, their predicted ultimate limits of detection are far from being achieved. It is the main purpose of this project to study and analyze the different sources of dissipation and frequency instability that determine the final performance of NEMS devices, to convey specificity to NEMS-based mass sensors and to broaden current fields of applications. This will be tackled using piezoelectric (PZE) transduction due to its high linearity and non-dissipative nature. Three work packages will be pursued, one covering each one of the objectives mentioned above. Devices will be analyzed in vacuum, air and interacting with liquid; and the intent is to optimize the performance in each environment separately and demonstrate the feasibility for commercial applications of some of the fabricated devices.",Advanced Resonant Nano Electromechanical SystemS,FP7,06 June 2019,01 January 2014,87500.0 HARVEST,Stichting VU-VUmc * Foundation VU - VUmc,energy,"Photoprotection against excess absorbed light energy is an essential and universal attribute of oxygenic photosynthetic organisms. This requirement has been a strong force in the evolution of plants and micro-organisms, and a diverse range of solutions have arisen. It has determined survival, productivity and habitat preference, and it determines the ceiling on the efficiency of energy conversion in photosynthesis in natural environment. Its investigation also provides insights into unique nanoscale switching processes. Understanding the molecular mechanisms of biological light adaptation will therefore have implication for many aspects of life, such as agriculture and food security, biodiversity and global climate change, biosolar energy and biofuels. This network brings together major high-quality EU centres with expertise in a wide range of disciplines -from plant physiology to molecular biology, structural biology and photophysics -and with great interest in interdisciplinary collaborative research. The network will thus provide a unique training opportunity for young researchers in key aspects of molecular biosciences and biophysical sciences in the context of practical applications in instrument development, agronomy, ecology and biotechnology. Researchers from within and outside this network will receive key research skills from several disciplines combined in a high-level and intrinsically collaborative research project, key transferable skills on information technology, written and oral communication and critical assessment, and key business and commercial skills on commercial exploitation and product development.",Control of Light Use Efficiency in Plants and Algae - From Light to Harvest,FP7,30 September 2013,01 October 2009,4683560.0 HDIMSM,Shanghai Jiao Tong University,manufacturing,"The capsid proteins of viruses have been shown to organize around a variety of non-biological polyanions, in a similar way that proteins assemble around RNA genomes, to form virus-like particles (VLPs). Metal-containing polymers such as polyferrocenylsilane possess additional interesting physical and chemical properties and may yield VLPs possessing very different morphologies and more diverse functionalities on co-assembly with capsid proteins. In a similar manner to almost all nanoscale objects, VLPs generally exist in the solid state but not in the liquid phase, because the scales of these systems are typically larger than the range of attractive interactions between such nanostructures. This situation comes with limitations regarding both storage and product formulation. Due to the recent development of liquid proteins via the surface engineering techniques, interest in the phase behavior of bionanomaterials has grown rapidly. The proposed research focuses on the fabrication and surface engineering of responsive VLPs through the self-assembly of polyferrocenylsilane-based copolymers and viral capsid proteins. This project is highly interdisciplinary and the project objectives will be accomplished by the proposed award of a Marie Curie Fellowship to a highly talented young scientist from China, Dr. Hongjing Dou. She has considerable expertise in the area of bionanomaterials and in biomedical science. The proposal involves her working at the School of Chemistry at the University of Bristol in the UK together with Prof. Ian Manners, who has expertise in the field of synthetic metallopolymers such as polyferrocenylsilanes and also self-assembly, and cosupervisor Prof. Stephen Mann, an expert in bio-inspired chemically-derived routes to complex materials and a pioneer of solvent-free liquid proteins and viruses, to achieve the ambitious project goals.","Self-Assembled Virus-Like Particles from Polyferrocenylsilane-Based Polymers and Viral Capsid Proteins: Fabrication, Surface Engineering and Applications",FP7,,,15000.0 HDIMSM,University of Bristol,manufacturing,"The capsid proteins of viruses have been shown to organize around a variety of non-biological polyanions, in a similar way that proteins assemble around RNA genomes, to form virus-like particles (VLPs). Metal-containing polymers such as polyferrocenylsilane possess additional interesting physical and chemical properties and may yield VLPs possessing very different morphologies and more diverse functionalities on co-assembly with capsid proteins. In a similar manner to almost all nanoscale objects, VLPs generally exist in the solid state but not in the liquid phase, because the scales of these systems are typically larger than the range of attractive interactions between such nanostructures. This situation comes with limitations regarding both storage and product formulation. Due to the recent development of liquid proteins via the surface engineering techniques, interest in the phase behavior of bionanomaterials has grown rapidly. The proposed research focuses on the fabrication and surface engineering of responsive VLPs through the self-assembly of polyferrocenylsilane-based copolymers and viral capsid proteins. This project is highly interdisciplinary and the project objectives will be accomplished by the proposed award of a Marie Curie Fellowship to a highly talented young scientist from China, Dr. Hongjing Dou. She has considerable expertise in the area of bionanomaterials and in biomedical science. The proposal involves her working at the School of Chemistry at the University of Bristol in the UK together with Prof. Ian Manners, who has expertise in the field of synthetic metallopolymers such as polyferrocenylsilanes and also self-assembly, and cosupervisor Prof. Stephen Mann, an expert in bio-inspired chemically-derived routes to complex materials and a pioneer of solvent-free liquid proteins and viruses, to achieve the ambitious project goals.","Self-Assembled Virus-Like Particles from Polyferrocenylsilane-Based Polymers and Viral Capsid Proteins: Fabrication, Surface Engineering and Applications",FP7,,,309235.2 HEALTHGOVMATTERS,Zeppelin University * Zeppelin Universität,health,"HealthGovMatters explores patients' and professionals' formal and informal involvement in governing the production and mediation of health and medical knowledge. We use rich social science and ethnographic methods, including interviews and participant observation, to address forms of engagement with predictive, diagnostic and therapeutic technologies. Our interest is in exploring interactions between constellations of actors (patients, care-givers, health professionals, citizens, and patient and professional organisations) who become involved in mediating and articulating the definitions and lived meanings of health, illness and disease in the context of encounters with new health technologies. We will focus on new imaging (predictive and diagnostic) technologies, computer implants and new pharmaceuticals/devices which are being developed and implemented in the fields of genetics and neurology - two key sites in which new technologies enabled by the synergism of developments in such core fields as nanotechnology, biotechnology, information technology and cognitive sciences are being integrated. Often referred to as 'converging technologies', their integration in the area of medicine is viewed as holding the potential to vastly improve ICT capacity for medical data management and information generation and to provide the foundation for the translation of research knowledge into clinical trials and clinical practice. In the light of new developments, we are asking: How do patients and professionals at the experiential and institutional levels represent new diagnostic, predictive or therapeutic possibilities and make decisions regarding their development and use? Additionally, in what ways might the axes of gender and generation (and more specifically women and children) make a difference in how novel health technologies are conceptualised, developed, implemented or refused?",Health Matters: A Social Science and Ethnographic Study of Patient and Professional Involvement in the Governance of Converging Technologies in Medicine,FP7,31 July 2012,01 June 2009,860478.0 HEALTHY AIMS,University of Vienna * Universität Wien,health,"In this project key microsystem technologies and communication methods will be developed that bring intelligence directly to the human, in the form of medical implants and ambulatory measurement systems, and also enable information from these devices to be transmitted out into the wider environment. The microsystem technologies to be developed can be applied to any generic Ambient Intelligent system comprising sensors, actuators, an intelligent processor and a wiring loom. The medical applications have been chosen for 2 reasons. Firstly, they will progress the existing State of the Art in Microsystems in terms of size, reliability, and power constraints far more than many other application sectors. In addition, there will be a direct positive impact into the health of EU citizens. The overall objective is to develop the technologies that go to make up a microsystem, and then produce specific medical devices to exploit these technologies. The 4 year project, with 27 partners, is structured with the focus on the microsystem technology development, most of which does not include silicon. This is seen as crucial if complete microsystems are to be realised in the coming few years. This project includes participants from all of the disciplines necessary to produce a complete generic microsystem. The result will be a range of core technologies and medical devices utilising these core technologies. Intelligence will be given back to people where part of their own internal system has failed. Quality of life will be improved for millions of EU citizens and the long term cost of treating people will reduce significantly. The resulting final medical products include cochlear and retina implants, nerve stimulation, bladder control and pressure monitoring systems. It is estimated from the available statistics that around 50% of the western population i.e. around 500 million citizens, will suffer from at least one of the health problems targeted in this project.",Nano scale materials and sensors and microsystems for medical implants improving health and quality of life,FP6,31 May 2008,30 November 2003,1.4999936E7 HEATCONDUCTIVES,Fundación INASMET,transport,"The project HeatConductives is focused on the improvement of efficiency and reliability of electronic systems by the use of new high heat conducting materials and products formed by the combination of Cu and new vapour grown carbon nanofibres (VGCFs) and nanotubes (CNTs) of outstanding thermal conductivity. Conventional and innovative manufacturing processes will be developed along the project to produce thin foils and 3D near net shape components. HeatConductives specifically addresses the requirement for a new low cost and easy to process material for the industrial requirement of adaptive heat-sinks to assist thermal management. This is an urgent problem, especially for new semiconductors (GaAs or GaN), needing better heat control to get their full potentiality. Heat management critically affects the electronics, microelectronics, telecomm, automotive and avionics industries, impacting speed, size, weight and reliability. This is especially critical for future components managing electric currents and packaging densities orders of magnitude higher than now. A new economically viable material is necessary to solve this problem and enable components with the highest performances. So, the HeatConductives project will develop a generic solution suitable for use across a wide range of European Industry serving the high thermal performance and reliability markets. The project target is to develop a heat-sink material with the advantages: - Reduced cost and increased heat conductivity than state of the art materials - Low and tailored CTE - Manufactured by high yield industrial processes (Tape Casting; Metal Injection Moulding) - Easy machinability The following partial objectives are summarised: - Development of heat conductive VGCNFs and CNTs. - Production of feedstock for MIM and TC with Cu and C. - Development manufacturing processes for MMCs",New High Heat Conducting Materials and Manufacturing Processes for Improved Efficiency of Heat Management and Packaging Components in Electronics,FP6,27 September 2007,28 June 2005,725132.0 HEATPRONANO,ICN2 - Institut Català de Nanociència i Nanotecnologia,information and communications technology,"The importance of controlling and understanding energy and heat flow, non-equilibrium processes and fluctuations at small length scales is rapidly gaining attention. This emerging field of nanoscale energy management, starts to play a crucial role in many solid-state device applications and its solution is a condition sine qua non for the adoption of future nanoelectronic devices. The need for energy management arises from new challenges brought by the quest of continuous performance improvements of nanoelectronic devices. The enhancement of the integration density of these devices increases the electronic performance but as the commercial field-effect-transistor approach the 10 nm regime, the thermal management becomes a serious issue.",Heat Propagation and Thermal Conductivity in Nanomaterials for Nanoscale Energy Management,FP7,02 May 2018,03 January 2014,0.0 HEATTRONICS,Aalto University * Aalto-yliopisto,information and communications technology,"Few systems in nature are entirely in equilibrium. Out of equilibrium, there are heat currents, and different degrees of freedom or parts of studied systems may be described by entirely different temperatures if the concept of temperature is at all well defined. In this project we will study the emergence of the subsystem temperatures in different types of small electronic systems, and the physical phenomena associated with those temperatures. Our emphasis is on the mesoscopic effects, residing between the microscopic world of individual atoms and electrons, and the macroscopic everyday world. In particular, we will research thermometry methods, different types of relaxation, magnitudes of fluctuations and effects at high frequencies. We will explore these effects in a wide variety of systems: normal metals and superconductors, carbon nanostructures, nanoelectromechanical and spintronic systems. Besides contributing to the understanding of the fundamental properties of electronic systems, our studies are directly relevant for the development of thermal sensors and electron refrigerators. The improved understanding of the thermal phenomena will also benefit the study of almost any type of a nonlinear phenomenon in electronics, for example the research of solid-state realizations of quantum computing or the race towards quantum limited mass and force detection.",Mesoscopic heattronics: thermal and nonequilibrium effects and fluctuations in nanoelectronics,FP7,12 July 2017,01 January 2010,1322371.2 HECTO,Royal Institute of Technology * Kungliga Tekniska Högskolan,information and communications technology,"In recent years efforts have been made to achieve higher data rates in optical communication systems. In the IST projects FASHION and TOPRATE it has been shown that data rates of 160Gbit/s can be transmitted using Optical Time Division Multiplexing. The focus of these projects has been in the optical domain rather than realization of cost-efficient components. Further IST-projects address IP-based optical networks and develop concepts for optical packet switched networks, e.g. IST-LASAGNE and IST-IP NOBEL. In optical packet networks, the next logical step after 10 Gigabit Ethernet (GbE) is 100GbE. The objective of HECTO is development of photonic components, transmitter and receiver, for high-performance and high-speed but cost-efficient communication systems. Applications are Time Division Multiplexed (TDM) optical systems with up to 160Gbit/s and optical packet networks based on serial 100GbE signals requiring about 110Gbit/s. Transmitters will be developed with Traveling-Wave Electro-Absorption Modulators with bandwidths of 100GHz or more, integrated with continuous-wave lasers. Electronic driver amplifiers and multiplexers will be developed for the connection between the modulators and external electronics at lower speeds. Receivers with bandwidths of 100GHz and above will be developed with waveguide pin diodes integrated with electronic amplifiers, and the required high-speed electronics for electrical clock recovery and demultiplexing to lower speeds. The components will be tested in systems experiments. To ensure that they will meet the demands of the future market, a techno-economic study will accompany the technical investigation and development. The HECTO project will allow European companies to gain share in the increasingly competitive photonic component and packet switching market. HECTO will form a basis for cost-efficient extension of European networks, and the introduction of end-to-end broadband services for all European citizens.",High-speed Electro-optical Components for integrated Transmitter and receiver in Optical communications,FP6,31 May 2010,31 October 2006,2364992.0 HELAT,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"The German applicant achieved his Dipl.Phys. at the University of Hannover, working on magneto-optical trapping of 85Rb with Prof.W.Ertmer. He has graduated to doctor of the University of Amsterdam in the group of Prof.J.T.M.Walraven, where he developed scientific expertise in collisional and collective behaviour of ultracold thermal clouds and Bose-Einstein condensation (BEC) of 87Rb. He now plans a project within the cold atom group at LKB/ENS in Paris. His program, elaborated with Prof.M.Leduc and Prof.C.Cohen Tannoudji, aims for studying BECs of metastable helium in a 3D optical lattice. Metastables have a unique feature due to their large internal energy, i.e. ionization by Penning collisions which allows highly sensitive detection. The primary goal is to study the real-time kinetics of the quantum phase transition from superfluid to Mott-insulator by monitoring the ion flux, caused by Penning collisions of atoms in each lattice site. Prof.G.V.Shlyapnikov in Orsay will provide theoretical assistance. The results will improve the understanding of the coherence of matter waves. For the success of this project the applicant will have to build up on his expertise and quickly advance to sophisticated methods, e.g. optical lattices, which offer perspectives in the domain of quantum computation. The cold helium group, one out of only 3 in the world with a helium BEC, has the appropriate infrastructure and funding for this 2 years project. Together with the female supervisor Michèle Leduc, the applicant will be involved in research management and supervise 2 PhD students, 1 postdoc and several undergraduates. His development will benefit from the excellent experimental and theoretical conditions at ENS and the shared expertise with the entire cold atom group, which hosts a number of young physicists from many international collaborations.",Metastable Helium Condensates in optical Lattices: kinetics of the Mott-insulator transition,FP6,30 September 2006,01 March 2006,149670.31 HELENA,Technische Universiteit Eindhoven * Eindhoven University of Technology,energy,"Nanowires are a powerful and versatile platform for a broad range of applications. Among all semiconductors, the heavy-elements materials exhibit the highest electron mobilities, strongest spin-orbit coupling and best thermoelectric properties. Nonetheless, heavy-element nanowires have been unexplored. With this proposal we unite the unique advantages of design freedom of nanowires with the special properties of heavy-element semiconductors. We specifically reveal the potential of heavy-element nanowires in the areas of thermoelectrics, and topological insulators. Using our strong track record in this area, we will pioneer the synthesis of this new class of materials and study their intrinsic materials properties. Starting point are nanowires of InSb and PbTe grown using the vapor-liquid-solid mechanism. Our aims are 1) to obtain highest-possible electron mobilities for these bottom-up fabricated materials by investigating new materials combinations of different semiconductor classes to effectively passivate the nanowire surface and we will eliminate impurities; 2) to investigate and optimize thermoelectric properties by developing advanced superlattice and core/shell nanowire structures where electronic and phononic transport is decoupled; and 3) to fabricate high-quality planar nanowire networks, which enable four-point electronic transport measurements and allow precisely determining carrier concentration and mobility. Besides the fundamentally interesting materials science, the heavy-element nanowires will have major impact on the fields of renewable energy, new (quasi) particles and quantum information processing. Recently, the first signatures of Majorana fermions have been observed in our InSb nanowires. With the proposed nanowire networks the special properties of this recently discovered particle can be tested for the first time.",Heavy-Element Nanowires,FP7,31 August 2019,01 September 2014,2698447.0 HELIOS,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),information and communications technology,"Organic semiconductors (OS) are organic materials with semiconductor properties. They are expected to change the electronics as we conceive it at the moment. OS allow producing flexible, large-area and low-cost devices and they are currently used in displays in mobile phones, MP3 players, digital cameras, radios, etc.",High Efficiency LIght-emitters with Organic Spintronics,FP7,07 July 2016,08 January 2011,0.0 HELIPORE,London School of Economics and Political Science,health,"Most of the current, second generation, methods for DNA sequencing are based on alternating cycles of enzyme manipulation and imaging the incorporation of fluorescently labeled nucleotides. These methods, however, hold several disadvantages, mainly the long duration of each sequencing experiment and the requirement for fluorescently labeled nucleotides and primer sequences. Tremendous efforts have been taken in order to develop cheap and ultra-fast sequencing systems. Specifically, the sequencing of single DNA molecules is of great importance, as no pre-amplification step and no labeled nucleotides are required. I intend to use biological nanometer-scale pores (alpha-hemolysin) modified with a DNA manipulating enzyme, a helicase, embedded in a membrane that separates two compartments, each contains an Ag/AgCl electrode, for the sequencing of single DNA molecules. Based on previous results, I expect that the ionic current, associated with DNA translocation through the nanopore, will exhibit a specific pattern for each nucleobase, allowing sequence determination. I intend to construct two different systems, in the first system the helicase will be soluble in the cis compartment, whereas in the second configuration the helicase will be attached to the nanopore via double stranded DNA linkers. The helicase enzyme will unwind double stranded DNA, form a ratchet-like movement of the DNA strand through the pore and control the pace of DNA translocation, leading to efficient sequencing.",DNA sequencing using helicase-modified alpha-hemolysin nanopores,FP7,15 April 2014,16 April 2012,209033.0 HEPTAG EXCHANGE,University of Navarra * Universidad de Navarra,health,"The Liver cancer drugs market is expected to become an active ground for competition in the future. According to recent market analysis, the liver cancer market in 2009 was valued at approximately US$0.4bn, indicating a growth rate of 27.1% between 2001 and 2009. It is estimated that the liver cancer market in 2017 will be $1.2bn, with a compound annual growth rate (CAGR) of 15.5% between 2009 and 2017. The growth of the liver cancer market is driven by the growth of the aging population, the greater access to medical care in the emerging new economic regions like China, and the innovative therapies such as targeted therapy In this project target delivery for liver cancer treatment using biomarker functionalized vehicles is planned. Due to the lack of the needed expertise in one centre or region a consortium is formed. The consortium focuses on the development of nano-vehicle materials for targeted delivery and the relevant practices towards in vitro level of understanding of the effect of the delivery systems on cancer cell treatment. In this consortium, four work packages (WPs) are formed, namely, WP-1: Pharmaceutical materials; WP-2: Formulations; WP-3: Cancer cell imaging; and WP-4: Cancer cell treatment. To support this consortium, biomarkers will be selected from the available products in terms of the functionality of the biomarkers. The consortium comprises 4 partners (2 from EU, 1 from China, and 1 from USA), who are centers of excellence in their unique areas of expertise: Sichuan for preparation of functional polymersomes, Navarra for drug formulations, FIU for cancer cell imaging, and UoW for cancer cell treatment. Most importantly is the development of novel liver cancer therapy, fostering strategic collaborations between EU and China and knowledge transfer and dissemination through staff mobility.",Targeted delivery for liver cancer treatment,FP7,31 December 2015,01 January 2012,105000.0 HERODOT,Universiteit Utrecht * Utrecht University,photonics,"Recent progress in the fabrication of colloidal semiconductor nanocrystals has led to a wide range of quantum dots with a high oscillator strength, photoluminescence efficiency and size-tunable emission spectrum. The present proposal 'Heterogeneous quantum rod and quantum dot nanomaterials' aims at a comprehensive research and training program on the opto-electronic properties of heterostructured nanomaterials based on quantum rod and dot building blocks. More specifically, we will study quantum dot molecules, binary quantum dot solids, superstructures of aligned quantum rods and hybrid organic/inorganic systems with specific band alignment (type II heterostructures). The optical properties of these systems, e.g. polarizability, exciton lifetime and emission spectrum are determined by the delocalized, indirect nature of the exciton; while optical anisotropy can be achieved by alignment of quantum rods. Such systems can exhibit a large Stokes shift, enhanced nonlinear refraction, and an absorbance and emission spectrum that can be tailored by the architecture of the superstructure and external fields. This forms a direct route to applications of these materials in optimizing light sources and realizing fast and compact optical modulators and switches. The proposed training and research program is based on three research lines, synthesis and processing, characterization and modeling, and manipulation and application. With this program, we form researchers that can cope with the complex, multidisciplinary problems that the European opto-electronic industry will face in the implementation of nanotechnology and nanophotonics.","Heterogeneous quantum rod and quantum dot nanomaterials, towards a novel generation of photonic devices",FP7,31 August 2012,01 September 2008,3208812.0 HEROMAT,"Faculty of Technology, Novi Sad * Tehnološki fakultet Novi Sad",construction,"The multidisciplinary research project will be directed towards the development of innovative environmental friendly materials with value added functions aimed to the protection of immovable Cultural Heritage assets. This project will cross-link an expert Pan-European team from the UK, Italy, Slovenia, Serbia and Russia, including experienced researchers and active participation of industrial partners - SME. The coordinated team work will be focused on the two historical objects located in urban (Serbia) and rural (Slovenia) environment, both having continental climate. The HEROMAT project investigation involves the chain of activities from the synthesis, establishment of the methodology for characterization and testing of novel protective materials through their pilot production and, finally, to the in situ application and monitoring on selected historical buildings, giving also their life cycle assessment. The outputs of this project will be a set of novel materials applicable for the protection of different inorganic mineral substrates providing multiple added functions: consolidation, self-cleaning and anti-microbial effect. The first layer will provide appropriate consolidation of the historical material, while the second layer will serve for its efficient protection. Additionally, the novel materials as a whole will possess good water vapor permeability. The connection between built-in and new materials will be realized through novel photocatalytic nanocomposites, anionic clays (layered double hydroxides) associated to TiO2 and/or other semiconductors. Therefore, the overall goal of the proposed project is the improvement of the physical state as well as the resistance to degradation of the monuments sustaining the functionality and the aesthetic appearance through a long period of time. The HEROMAT project will contribute to an effective, long-lasting solution, keeping the authenticity of the cultural assets and having socio-economic benefits.",PROTECTION OF CULTURAL HERITAGE OBJECTS WITH MULTIFUNCTIONAL ADVANCED MATERIALS,FP7,11 June 2017,12 January 2011,2592189.0 HESPERUS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"HESPERUS aims at enabling cross-disciplinary training and research at the interface between Electrical Engineering, Supramolecular Chemistry, Materials- and Nano-Science and Physics. The overall goal of HESPERUS is to generate new scientific and technological knowledge by combining supramolecularly engineered nanostructures (SENs), mostly based on organic semiconductors, with tailor-made interfaces to textured solid substrates and electrodes, for fabricating prototypes of two-terminal devices (supramolecular wires) and three-terminal devices (field-effect transistors). The training and research objectives of HESPERUS are: 1. Surface texturing: derivatization of electrically conductive solid substrates and metallic nanostructures to achieve a full control over the surface work-function, wettability and adhesion, thus ultimately to be able to tune the self-assembly of electroactive molecules at surfaces into pre-programmed supramolecular assemblies. 2. Hierarchical self-organization on textured surface of multifunctional SENs based on electrically/optically active functionalized carbon-based (I) 2D nano-objects such as n- and p-type discotics (perylenediimide and hexabenzocoronene derivatives) and (II) polymeric multichromophoric architectures at surfaces on the functionalized substrates. 3. Nanochemistry and nanoprobes: Scanning probes (AFM, STM, KPFM, C-AFM) quantitative time and space resolved characterization of various physico chemical properties of SENs, in particular correlation between structural and electronic properties. 4. Fabrication of supramolecular wires and transistors: Measurement of charge mobility in SENs two- and three-terminal devices varying systematically the wire’s (1) chemical composition, (2) conformation, (3) length and (4) doping.",Hierarchical self-assembly of electroactive supramolecular systems on pRe-patterned surfaces: multifunctional architectures for organic FETs,FP7,04 July 2010,04 August 2008,162985.98 HETERO2D,University of Manchester,information and communications technology,"We propose a new paradigm in materials science – heterostructures based on two-dimensional atomic crystals (and their hybrids with metallic and semiconducting quantum dots and nanostructures), and develop several devices which are based on such concept. Two-dimensional (2D) atomic crystals (such as graphene, monolayers of boron nitride, molybdenum disulphide, etc) possess a number of exciting properties, which are often unique and very different from those of their tree-dimensional counterparts. However, it is the combinations of such 2D crystals in 3D stacks that offer truly unlimited opportunities in designing the functionalities of such heterostructures. One can combine conductive, insulating, probably superconducting and magnetic 2D materials in one stack with atomic precision, fine-tuning the performance of the resulting material. Furthermore, the functionality of such stacks is “embedded” in the design of such heterostructure. We will create several types of devices based on such heterostructures, including tunnelling transistors, charge and spin drag, photodetectors, solarcells, lasers and other optical and electronic components. As the range of available 2D materials broadens, so the possible functionality of the 2D-based heterostructures will cover larger and larger area. We will concentrate on creating and understanding of the prototypes of such hetersotructures and apply efforts in developing methods for their mass-production suitable for various applications. The development of such novel paradigm in material science will only by possible by bringing together a Synergy group of researchers with complementary skills, knowledge and resources.",Novel materials architecture based on atomically thin crystals,FP7,10 July 2021,11 January 2013,1.3352308E7 HETEROMOLMAT,Institut Català d'Investigació Química (ICIQ) * Institute of Chemical Research of Catalonia,photonics,"Europe has world leading expertise in the fields of both supermolecular photochemistry and optoelectronic applications of nanocrystalline metal oxide films. This programme brings together expertise from both of these fields to adress the development of innovative heterosupermolecular devices which combine the specificity and unique functionality of supermolecular chemistry with the nanometer scale strcutural control and ease of integration into electronic devices of nanocrystalline metal oxide electrodes. The project will be science focused, with specific technological objectives. Key scientific elements of the project will be the synthesis of supermolecular structures designed both to achieve the desired functionality and including binding groups for ligation to metal oxide surfaces, the self-assembly of these structures on the surface of mesoporous, nanocrystalline films, the electrochemical and photochemical evaluation of the resulting heterosupermolecular systems, and the functional evaluation of these systems for technological applications. The project will target the demonstration of four innovative heterosupermolecular devices: ligth emitting diodes, optical data storage devices, magneto-optical data storage devices and electro-optical sensing and switches. The proposal will be at the meeting point between supermolecular chemistry, nanostructured inorganic materials science and optoelectronic device physics. It is therefore highly multidisciplinary and involves leading European groups working in organic, inorganic, biology, physical and materials science. This project will develop a critical mass of expertise targeting this innovative approach to optoelectronic devices, allowing Europe to establish a scientific world lead which will form a secure basis for technological exploitation.",Nanocrystalline Heterosupermolecular Materials for Optoelectronic Applications,FP6,31 October 2008,01 November 2005,1850000.0 HETMAT,University of Nova Gorica * Univerza v Novi Gorici,energy,"The aim of this project is to synthesize and assemble novel nanomaterials for the purpose of water splitting through a rational design process. To achieve efficient water splitting we want to mimic photosynthesis in green plants by using the so-called Z-scheme. Briefly, the Z-scheme consists of two photosystems abbreviated as PSI and PSII. When the photosystems are illuminated with light, electrons both in PSI and PSII are excited to a higher level. Due to the specific band offset in these photosystems the photogenerated electrons in PS II are transferred to the highest occupied molecular level of PS I. These electrons then recombine with holes photogenerated at PS I. While the photogenerated electrons in PS I participate in reduction of protons to produce hydrogen, the holes in PSII oxidizes water molecules, producing oxygen. By mimicking such a Z-scheme, we expect the probabilities of charge recombination to decrease significantly, resulting in more efficient hydrogen generation. We want to design novel nanomaterials by modifying a Z-scheme type system with the following changes: 1) to engineer an interface between two different nanomaterials or to link them using a solid state electron mediator, 2) to synthesize a single heterostructure material that meets the band offset requirements, and 3) to selectively deposit metal nanoparticles only on the semiconductor phases designated as PSI. Introducing modifications into a Z-type-scheme will offer the capability of using semiconductors with band gaps less than thermo-dynamical limit (1.23 eV/pH=0) for water splitting and improve photostabilities of many catalysts. The project will primarily aim at boosting the photocatalytic activities of nanomaterials for overall water splitting i.e. attaining a quantum yield above 6.3 % at 420 nm. From the perspective of commercialization, templating systems combined with wet-chemistry synthetic routes will be developed for the preparation of the nanomaterials.",Heterostructure Nanomaterials for Water Splitting,FP7,31 October 2016,01 November 2012,100000.0 HI-ONE,Universiteit Twente * Twente University,health,"This project aims at combining inorganic and organic materials in hybrid nanoelectronic structures for addressing a set of key problems in solid-state physics: (1) the magnetic ordering of 2D spin systems and their interaction with conduction electrons, (2) the coherent transport properties of organic molecules, and (3) reliable electronic characterization of single nanostructures. For all objectives we will integrate top-down and bottom-up (self-assembly) techniques, benefitting from strong collaborations with leading chemistry groups. For Objective 1, we will apply self-assembled monolayers of organic paramagnetic molecules on various substrates. This geometry offers great tunability for the nature, density and ordering of spins, and for their interaction with underlying electrons. We will study (many-body) phenomena that lie at the very heart of solid-state physics: the Kondo effect, RKKY interaction, spin glasses and the 2D Ising/Heisenberg model, addressing open questions concerning the extension of the Kondo cloud, RKKY-Kondo competition, and the relevance for high-Tc superconductivity. For Objective 2, molecular monolayers are inserted in an electron interferometer, allowing a systematic study of molecular charge coherence. We will study how coherence depends on the molecule s characteristics, such as length and chemical composition. For Objective 3 we will attach single nanostructures (quantum dots) by an innovative self-assembly method to highly-conductive, selectively metallized DNA molecules, bridging the gap between nano and micro. A crucial advantage compared to conventional (top-down) nanocontacting schemes is the high control and reproducibility afforded by sequence-specificity of DNA hybridization, enabling a wide range of fascinating experiments.",Hybrid Inorganic-Organic NanoElectronics,FP7,30 November 2014,01 December 2009,1750000.0 HICAT,Evonik Industries AG,environment,"Hierarchically organised metal organic catalysts shall be developed which can be easily recycled in multi-batch processes or which can be used in continuous processes without loosing the original advantages of the corresponding homogeneous soluble metal organic catalysts - high selectivity, activity and stability. The catalysts will be constructed using components at the nano-scale in a bottom-up approach. Hereby, catalytically active metal complexes will be linked with nanoparticles such as polymeric microgels, hyperbranched polymers or hybrid systems consisting of silsesquioxanes attached to hyperbranched polymers. Further hierarchical organisation of HiCat catalysts will be accomplished by interconnected networks formed from the assemblies of catalytic nanoparticles using end-functional T-responsive polymers that can interact with functionalities on the surface of the nanoparticles as binding agents. Recycling of the catalyst-nanoparticle entities in multi-batch operation will be studied utilizing the change of solubility of the polymer supported catalysts by external stimuli. Based on polymer-nanoparticles linked by T-responsive polymers, new types of films and membranes with graded porosity can be prepared by varying the size of the nanoparticles and the length of T-sensitive polymers. This opens new opportunities for integration of catalytic steps and separation within the hierarchically structured system and, hence for continuous reactor operation. The proposal combines the superiority of homogeneous metal-organic catalysts often possessing nearly 100 % selectivity with the advantage of efficient separation by grabbing a new concept for building up hierarchically organised catalytic systems. Structural principles of tailor-made ligands will be transferred into tailor-made functional surfaces of nanoparticles. For proof of principle of the concept, three types of reactions will be studied: olefin metathesis, CX coupling and enantioselective hydrogenation.",Hierarchically Organized Metal Organic Catalysts for Continuous and Multi-batch Processes,FP7,08 July 2013,09 January 2008,2647217.0 HIDDENTIMENMR,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"NMR spectroscopy detects in a unique way with atomic resolution biomolecular dynamics in the previously hidden time range between approximately 5 nano- to 50 microseconds (ns-ms time range). The detection of this motion happens in equilibrium under physiological conditions without the need for a triggering reaction. On the example of ubiquitin, this dynamics was found by us to be important for molecular recognition between proteins implying conformational selection rather than induced fit. Only free solution ensembles including this dynamics accessed the full conformational heterogeneity of structures in recognition complexes. Molecular dynamics analysis suggests high correlation of these ns-ms dynamical modes. Here, we propose to establish with NMR experimentally the correlated nature of the ns-ms dynamics, to describe ensembles reflecting ns-ms and sub-ns dynamics by separating the time scales. In this context, using temperature jump-infra-red spectroscopy and solid state NMR we want to determine the time scale of the ns to ms motion more precisely. Since the ns-ms time scale is slower than diffusion, dynamics on this time scale could be a mechanism of regulating or limiting the kinetics of molecular association and recognition. Therefore, we want to determine on-rates by NMR spectroscopy and want to explore whether mutants that do not affect the binding interface but will affect the dynamics modulate the on-rates. This would allow the control of binding kinetics and explore the influence of ns-¼s dynamics on protein-protein recognition on the long run also for membrane proteins. In addition specificity for drug interactions could be increased addressing extremal conformations present in the ns-¼s ensembles for homologous proteins with otherwise very similar average structures at interaction interfaces. If the proposal is successful this would open up new opportunities for drug design and design of protein-protein interactions.",NMR detected nanosecond to microsecond dynamics for biomolecular recognition dynamics,FP7,30 June 2014,01 July 2009,2212000.0 HIDING DIES,Technical University of Berlin * Technische Universität Berlin,information and communications technology,"The HIDING DIES project aims to develop a highly innovative technology for embedding active chips into high-densityprinted circuit boards. This 3-dimensional integration will enable a high degree of miniaturization, improved electrical andthermal performance for mobile and communication products.The technological steps are bonding of thin chips (50 µm) on multilayer substrates, embedding of the chips by vacuumlamination of a dielectric layer (RCC), followed by laser drilling of via holes to the chip contacts and to the substrate andfinally metallization of vias and conductor lines. For a further increase of functional density integrated passive components can be combined with the chip embedding. The resulting sub-systems with integrated components additionally allow assembly of surface mount devices on the bottom and top surface.All required process steps will be based on existing technologies, however their combination to a cost-effective high-yielding technology require significant scientific and technological research. Besides the process development, a detailedunderstanding of thermo-mechanical, thermal and electrical performance of such integrated systems has to be achieved.Furthermore development effort has to be made to explore technological limits by handling and bonding very large and very thin chips ( 50 µm) and by stacking multiple layers with integrated components.The achievement of the development goals will be assessed using two demonstrators, specified by end users. A sensordevice combines a surface mounted MEMS chip with embedded control circuits, resulting in an extremely small footprint.The other demonstrator is a power RF application. Target is to create a miniaturized module with excellent electrical andheat conducting properties. With the IC's embedded in the substrate, short connections to filter structures and assembled discrete SMD's at the surface, a compact miniature module can be created.",High Density Integration of Dies into Electronics Substrates,FP6,30 June 2007,30 December 2003,1870154.37 HIENA,University of Cambridge,energy,"Over the past years, carbon nanomaterial such as graphene and carbon nanotubes (CNTs) have attracted the interest of scientists, because some of their properties are unlike any other engineering material. Individual graphene sheets and CNTs have shown a Youngs Modulus of 1 TPa and a tensile strength of 100 GPa, hereby exceeding steel at only a fraction of its weight. Further, they offer high currents carrying capacities of 10^9 A/cm², and thermal conductivities up to 3500 W/mK, exceeding diamond. Importantly, these off-the-chart properties are only valid for high quality individualized nanotubes or sheets. However, most engineering applications require the assembly of tens to millions of these nanoparticles into one device. Unfortunately, the mechanical and electronic figures of merit of such assembled materials typically drop by at least an order of magnitude in comparison to the constituent nanoparticles. In this ERC project, we aim at the development of new techniques to create structured assemblies of carbon nanoparticles. Herein we emphasize the importance of controlling hierarchical arrangement at different length scales in order to engineer the properties of the final device. The project will follow a methodical approach, bringing together different fields of expertise ranging from macro- and microscale manufacturing, to nanoscale material synthesis and mesoscale chemical surface modification. For instance, we will pursue combined top-down microfabrication and bottom-up self-assembly, accompanied with surface modification through hydrothermal processing. This research will impact scientific understanding of how nanotubes and nanosheets interact, and will create new hierarchical assembly techniques for nanomaterials. Further, this ERC project pursues applications with high societal impact, including energy storage and water filtration. Finally, HIENA will tie relations with EU's rich CNT industry to disseminate its technologic achievements.",Hierarchical Carbon Nanomaterials,FP7,31 December 2018,01 January 2014,1496379.0 HIERARCHY,Stichting Katholieke Universiteit * Catholic University Foundation,manufacturing,"The mission of HIERARCHY is to train and educate young scientist in the rapidly developing field of nanosciences, in particular hierarchical self-assembly. The training programme educates early stage and experienced researches in many aspects of this highly interdisciplinary field, such as theory, materials chemistry and biochemistry, advanced characterisation techniques, physics and commercial device development. In addition, the training programme will address non-scientific issues, important for the career development of young scientists, e.g. communication and presentation skills, IPR and entrepreneurial skills, ethical issues, language enhancement and cultural awareness. The training takes place on a Network level and also locally at the host institutions. HIERARCHY’s training programme will deliver versatile individuals with a broad scientific knowledge, ready to pursue a successful career in the European industry or academia. The interdisciplinary research training is centralised around the novel concept of hierarchical assembly in controllable matrices. This concept exploits liquid crystalline media as controllable matrices for programmed self-organisation, which goes far beyond the possibilities of currently employed techniques. A liquid crystal matrix in combination with a variety of simultaneously or sequentially applied external stimuli will yield a unique toolbox to build functional macroscopic structures with nanometer control. Leading European laboratories in soft condensed matter and solid state matter will work towards new paradigms in nanosciences. HIERARCHY’s intention towards application of the designed structures, illustrated by the presence of three industrial partners in the consortium, is an important step towards commercialisation of nanosciences in Europe. With Europe’s desire to become the major player in the area of nanosciences, valorisation of developed technology is a key lesson for Europe’s new generation of nanoscientists.",Hierarchical Assembly in Controllable Matrices,FP7,10 July 2014,11 January 2008,4648957.0 HIERARSACOL,Universiteit Utrecht * Utrecht University,photonics,"Goal: to significantly extend our ability to manipulate the Self Assembly (SA) of colloidal nanoparticles (NPs) into complex 1D/2D/3D architectures (regular clusters, (composite)strings/rods, sheets, submicron colloidal crystals/liquid crystal phases of the NPs) over multiple length scales going from nano to that of granular matter. In the nano-regime quantum size effects cause materials properties to become strongly size dependent and thus highly tunable. Moreover, the synthesis of many NPs (metals, semiconductors, magnetic materials) is advanced enough that they can be made to crystallize into regular 3D lattices with new exciting functionality caused by collective effects. By performing SA in several independent stages, materials properties can be further tailored in new ways because of both access to different length scales and different NP combinations. In order to make systematic progress we will determine inter-NP potentials using 3D imaging. Both using subdiffractive confocal microscopy and cryogenic tomographic transmission electron microscopy. We will also use external fields (optical tweezers, electric/magnetic fields, shear) both to realize the complex architectures, but also to change particle properties dynamically. E.g., in monodisperse droplets of nematic phases of luminescent rodlike NPs an electric field can dramatically affect the scattering and emission of individual droplets. The droplets can subsequently be ordered in strings, sheets or crystals. Repeating the SA again delivers supra structures on the granular scale to tune e.g. heat or reagent flows. These projects combined will not only deliver new fundamental knowledge on SA, but the results are also expected to be directly useful for realizing applications based on the new meta-materials realized such as in displays, lighting, (optical) storage, (bio)sensing, catalysis, spintronics, photonic crystals, and the opto-electronics field in general.",Hierarchical Self Assembly of Colloids: Control and Manipulation from Nano-Granular,FP7,31 May 2017,01 June 2012,2494334.0 HIFIVENT,Fundación Tecnalia Research & Innovation,construction,"Buildings are called upon to be integrated in the urban spaces, which needs aesthetic requirements of the external envelop. Moreover, the façades of buildings must be long-lasting and ensure well-being inside the building (thermal isolation, walls breathing). Nowadays major activity in the construction sector in Europe is retrofitting, representing the 42% of existing buildings and making up about 75% of the building stock in 2050. Most of these activities are linked to ageing of the façades and solving of insulation problems, where the Ventilated façades are considered as one of the most efficient systems. Current systems present disadvantages related to corrosion, environmental impact (aluminium), recyclability, size and weight (ceramic, stone…). An environmental-friendly solution, overcoming all the mentioned drawbacks and with natural aesthetic appeal is wood, but the material lacks the necessary durability for outdoor exposition. This drawback can be addressed by new technological materials which incorporate wood in a high per cent, combining it with polymers (Wood Polymer Composites/WPCs). WPCs offer better thermal and acoustic isolation than aluminium, and better durability than wood. However it can be stated that although durability is highly increased, it continues being the main problem. When using WPCs as building components another problem arising is their poor fire performance. HIFIVENT aims the development of a WPC based ventilated façade addressing the following issues:",High durability and fire performance WPC for ventilated façades,FP7,03 July 2018,10 January 2013,0.0 HIGH-VOLTAGE PV,Bar-Ilan University,energy,"Global warming caused by the combustion of fossil energy carriers is the biggest ‎environmental threat for the 21st century, which has boosted the demand for ‎‎'clean energy'. Scientific breakthroughs are needed in the photovoltaic (PV) sector to reduce ‎the price of PV-generated electricity and thus to become compatible with ‎conventional power plants. This can only be achieved with new type of solar ‎cells comprising of novel materials which are cheaper than current silicon ‎technology and which allow large scale production at low cost. Nano-‎structured solar cells such as the dye-sensitized (DSSC), quantum dot ‎sensitized or polymer based solar cells are promising candidates. Until now ‎improvement of such cells aims mostly towards the modification of one ‎component within existing cell architectures (for example the investigation of ‎several dyes in DSSCs, while the electron and hole conducting media remain ‎unchanged). It is the intention of the proposed research to investigate ‎materials which have not been attracted considerable attention for ‎photovoltaic applications as well as materials which are already widely used. In a first step we aim to screen materials for solar ‎cells which are based on a large bandgap window layer and a absorber with a ‎bandgap between 1.4 -2.8 eV. This requires the preparation of a large number of devices and the acquisition ‎and analysis of huge amount of data. We intend to adopt techniques ‎commonly used in pharmacy and biology, where large amounts of samples ‎are screened and analyzed. ‎In the second phase the photovoltage limitations are investigated and the voltage will be maximized. In the final phase interface geometry will be changed to increae the photocurrent.",New materials for high voltage solar cells used as building blocks for third generation photovoltaics,FP7,28 February 2011,01 March 2009,183052.0 HIGHREX,Silex Microsystems AB,health,"Breast cancer is currently the most common cause of death for women below seventy years of age and currently over 100 million European women are screened every year for early detection through mammography.The objective of the proposal is to increase the efficiency in detection and diagnosis of breast cancer and thus to decrease the mortality in breast cancer. To achieve this we will develop a novel imaging method based on recent results in the research fields of nano-technology, x-ray optics, detector technology and integrated electronics. The new modality will be designed by leading European industry and SMEs in these areas and develop the only commercially available European detector platform for digital mammography today into a leading technology platform for tomorrow. The novel method will provide significantly increased contrast and spatial resolution compared to current state-of-the art breast imaging through elimination of noise from electronics as well as from overlapping tissue and by way of utilizing the signal more efficiently through fast single photon counting parallel processing integrated circuits. To make sure that the project target the right issues in breast imaging experienced mammography doctors from several European breast imaging centres are involved in the project and they will also test and evaluate the new imaging system and compare it to current state-of-art mammography as well as ultrasound and MR imaging of the breast. The clinical trials will involve an enriched population of symptomatic women and the potential impact on European screening for and diagnosis of breast cancer will be estimated from the results. In summary the project will have significant impact on European healthcare and make European industry a leader in the area of breast imaging.",High Resolution X-ray Imaging for Improved Detection and Diagnosis of Breast Cancer,FP6,31 August 2010,01 March 2007,3635200.0 HIGHSPIN,University of Cambridge,manufacturing,"The aim of the HIGHSPIN project is to incorporate tunable, highly spin-polarised (THSP) materials into spintronic devices and utilise them in new 2D and 3D nanomagnetic data storage architectures.","Tunable, highly spin-polarised materials for spintronics and non-volatile memories",FP7,08 July 2017,09 January 2012,0.0 HIGRAPHEN,IMEP-LAHC Laboratory,information and communications technology,"This project is based on the application of layer-by-layer (LbL) technology for the development of a versatile and generic procedure for the fabrication of hybrid devices involving graphene and materials of a different nature such as polymeric, organic, and inorganic entities. The project aims to achieve the organization and integration of graphene sheets with heterogeneous components of different sizes and compositions into higher level structures/assemblies and devices. Components include polymer molecules, magnetic nanoparticles, nanorods and quantum dots.",Hierarchical Functionalization of Graphene for Multiple device fabrication,FP7,02 April 2020,03 January 2014,0.0 HIM,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),information and communications technology,"The continuous progress in micro and nano-system technologies has allowed the successful development of many innovative products in process control, environmental monitoring, healthcare, automotive and aerospace as well as information processing systems. In the training course 'Highlights in Microtechnology' (HIM) an overview will be given of modern micromachining applied to the realization of miniaturized systems. The events foresees a common core on the fundamentals of microtechnology, high-resolution microscopy, microsystems, microrobotics, UV-photolithography for microstructuration, micromolding and hot embossing. We then present the general tools for microtechnology and their different hot fields of application as life sciences, satellite communication, MEMS for spatial applications and micro-optics and metrology. The structure of the course foresees 10 intensive days on relevant topics at the heart of microtechnology including lectures and hands-on experiences in clean-rooms and laboratory. The topics of the laboratory sessions are High resolution microscopy: AFM, ESEM, TEM, Image processing, Hands-on optical MEMS, Micro-optical components. Visits to high-tech companies are the agenda. Two keynote speakers will give a lecture during each course. A permanent e-forum will be established. It will be open to all the participants, trainers and committee members in order to generate a durable networking related to scientific and technological questions in microtechnology. We propose a series of four events to be held one a year in the region of Neuchâtel (CH) and Franche-Comté (F) at the heart of microtechnology. We believe that there is an increasing need of education to be satisfed in the field of microtechnology. In particular, young scientists who sees the opportunity to follow the courses could boost their standings in the high tech European job market.",Highlights in Microtechlogy,FP6,31 January 2010,01 February 2006,388324.35 HIMAMIS,Autonomous University of Madrid * Universidad Autónoma de Madrid,energy,"As it is well-known, it is a fact that one of the biggest problems that concern the current world is relative to the high energy consumption. This proposal is relative to the solar cell, in special with the third generation. This new generation of solar cells is created to obtain high efficiency and low cost conversion devices. Therefore, they are a potential component for the future. The proposal presents the know-how for the design, growth and improvement of the multiband solar cell. So far, this kind of solar cells are a specific topic of the Renewable Energies in the European Union Seventh Framework Program (FP7). However, despite a considerable effort of many research groups, there was no evidence of a working multiband photovoltaic device. Recently, the applicant, within a group at the Lawrence Berkeley National Laboratory in the USA, has designed, grown, tested and demonstrated the first multiband device, growing by dilute nitrogen, and being this concept the transfer technology relate to this proposal. Relying on the technological capabilities of the host institution, its deep knowledge on nanotechnology and its recent activities on new efficient solar cells, the new incorporated know-how will boost the activities of host institution to the topmost frontier of knowledge and development within the solar energy field.",Highly mismatched alloys to implement multiband solar cells,FP7,20 March 2015,21 March 2013,230036.0 HINAMOX,Center for Cooperative Research in Biomaterials * Centro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE),health,"Metal oxide and metal NPs are particularly dangerous for two reasons: their special catalytic activity coming from the properties of their nanointerface may interfere with numerous intracellular biochemical processes and the decomposition of NPs and the ion leakage could heavily interfere with the intracellular free metal ion homeostasis, which is essential for cell metabolism. A very specific problem is the difficulty of localizing and quantifying them in cells. Obtaining dose effect relationships is not simple, because of the unknown amount of material present in affected cells. The following main points will be addressed in this proposal:1) Design and synthesis of metal oxide and metal NPs, which can be traced by SPECT, PET, and fluorescence techniques and the appropriate characterization of these NPs.2) Application of label-free techniques, such as IBM and EM to ensure that the radioactive and fluorescent constituents do not modify the cytological and organismic response by themselves.3) Characterization of the uptake, distribution kinetics and NP release at the level of the organism.4) Study of the interaction of NPs with plasma components forming complexes with NPs and the assessment of their possible impact on the uptake compared with that of bare or capped particles.5) Quantification and localization of metallic NPs in immune competent cells is a key task for the establishment of proper dose-response correlations. A technique applicable with living cells as ultimate control will be IBM, capable of detecting single metal NPs in cells at different depths.6) Development of sophisticated cell physiological approaches focusing on the determination of oxidative activity, cytokine production and adaptive processes concerning signalling pathways beyond standard vitality tests. The research project will indicate toxic levels of various NPs and sub-toxic effects will be investigated by analysing the signalling response of immune cells","Health Impact of Engineered Metal and Metal Oxide Nanoparticles: Response, Bioimaging and Distribution at Cellular and Body Level",FP7,30 September 2012,01 October 2009,2297337.0 HIPERBAT,Technische Universiteit Delft * Delft University of Technology,energy,"One of the great challenges of this century is unquestionably energy storage. Storage is essential to make more efficient use of renewable energy sources and to enable electrical mobility. Recent developments have raised both hopes and fundamental challenges in the next generation Li batteries (including Li-ion and Li-air/Li-sulphur). Despite large research efforts, the improvement of battery performance over the last decades has been relatively small because the full potential of the storage materials is not utilized. Most of the attention has been devoted to the development of new electrode materials; however, marginal understanding has been achieved of the functioning of these materials in electrodes. The key problem is that established micro and macroscopic methods are not sensitive to the relevant time and length scales under the required in-situ conditions. Moreover, up to date calculational models do not represent the full complexity of the electrode systems. Using novel experimental and calculational approaches this project aims at fundamental understanding and improvement of Li electrodes. This requires a broad multidisciplinary approach, ranging from nuclear magnetic resonance probing nanoscopic charge transfer to in-situ neutron depth profiling exploring the mesoscopic charge transport. Calculations will combine the complex solid state diffusion in storage materials with the mesoscopic charge transport through the electrodes. By systematic variation of the electrode micro and nanostructure, this will lead to deep fundamental understanding. This project will be the first major systematic study on the fundamentals of complete electrodes. By bringing our current understanding from the level of the storage material towards complete electrodes, it will also pave the way to optimal high performance energy storage in batteries. The impact on society cannot be overstated as energy storage is a key enabler for the use of renewable energy and electrical transport.",Hunting for high performance energy storage in batteries,FP7,31 December 2017,01 January 2013,1497838.0 HIPERDART,MOLECULAR STAMPING SRL,health,"Development of High Performance Diagnostic Array Replication Technology (HiPerDART) As with any new technology, the use of DNA microarrays has presented a number of important obstacles, many of which have limited their ability to move beyond research applications. For example, the data obtained from a traditional microarray experiment can fluctuate dramatically due to small perturbations in assay conditions. This fact, when coupled to the often extensive workflows required to perform an assay, has caused many experts to conclude that microarrays are not well suited to clinical applications. Other factors as limited content flexibility and high production costs contribute to this negative image. It is the aim of the present HiPerDART project to develop a higher standard (clinical) microarray technology platform, by proposing a highly innovative probe printing technology, called Supramolecular NanoStamping (SuNS). Moreover, since at the same time in HiPerDART both assay workflow will be minimized and signal-to-noise ratios will be improved, our technology platform promises to dramatically improve the reliability (reproducibility and costs) of these (medical) tests. Furthermore, in an industry dominated by U.S. players, it is imperative to establish a strong European presence at this early stage in the development of the clinical market. By using a complex disease as colon cancer to prove the strength of the HiPerDART microarray technology platform, already in the limited lifetime of this project a first HiPerDART diagnostic microarray test will be validated.",Development of High Performance Diagnostic Array Replication Technology,FP7,31 December 2012,01 January 2009,2999882.0 HIPERMAG,Universiteit Twente * Twente University,health,"HIPERMAG aims to develop the recently discovered superconducting material MgB2 into a technical superconductor. This new material has the potential to become the conductor of choice in various existing applications, as well as to play a pivotal role in the breakthrough of superconducting technology in the energy domain. A key advantage of MgB2 over low temperature superconductors is its higher operating temperature, reachable with liquid-cryogen free coolers. This lowers cooling cost, simplifies system design and increases safety. Within a decade, MgB2 will replace NbTi in all applications involving medium-range magnetic fields. The most significant of these is medical MRI, a substantial market in which European companies have a dominant position. Maintaining this competitiveness calls for European research to be at the fore of these developments. Compared to high temperature superconductors, MgB2 conductors will be a factor 10 less expensive. Presently, the cost of HTS wires slows down the penetration of superconducting technology in the energy domain, where superconductors offer substantial savings in monetary and ecological terms as well as additional functionality. The availability of a suitable low-cost conductor will greatly accelerate this evolution. However, before it can realise this double potential, the performance of MgB2 has to be enhanced in two respects. Firstly, the maximum magnetic field at which it can operate needs to be increased by modifying the nano-structure of the MgB2 crystallites inside the superconducting filaments. The effectiveness of such nano-composites has been demonstrated on a lab-scale, but now needs to be obtained with scaleable, low-cost processes. Secondly, the maximum current that MgB2 conductors carry is presently limited by thermal instabilities. These can be reduced through careful design of the conductors composite micro-structure. The consortium partners are leading European institutes with a long term commitment to the #",Nano- and micro-scale engineering of higher-performance MgB2 composite superconductors for macro-scale applications,FP6,31 January 2008,01 September 2004,2499996.0 HIPIN,TWI Ltd.,construction,"The concept of High Performance Insulation Based on Nanostructured Encapsulation of Air (HIPIN), described in this proposal, is to develop a sustainable and affordable technology to produce a nanostructured thermal insulating coating to improve thermal efficiency in new and retrofitting buildings. The insulating material will have enhanced performance compared with the state of the art products and will contribute to the protection of the environment through the reduction of greenhouse gases generated in heating and cooling the building.",High Performance Insulation based on Nanostructure encapsulation of air,FP7,03 July 2017,11 January 2011,0.0 HIPPOCAMP,University of Oulu * Oulun Yliopisto,energy,"European industries such as automotive, aerospace and manufacturing have to develop new structural materials and production processes in order to achieve strict emission reduction requirements and improve performance and multifunctionality. However, advanced engineered materials manufactured today with traditional techniques are prohibitively expensive for many applications and generate unwanted by-products and toxic waste. The HIPPOCAMP project focuses on the development of a robust, high-yield, low cost, environmentally friendly manufacturing process to produce nano-composites for products made of engineered metallic material, in particular, structural components for automotive, aerospace, manufacturing and wind turbine applications. One of the most desired functional property of such components is vibration damping, because vibration and chatter in turbine blades, machine-tools and other industrial components have very significant consequences: decreased performance, higher maintenance costs, shorter service life and ultimately, higher costs. The HIPPOCAMP project develops a novel method to generate a unique carbon-based composite with high dynamic stiffness material, whose effect on vibration damping will prolong the service life of components, reduce their weight and significantly improve the performance of industrial machineries. Today, there are no standard structural materials that can simultaneously combine high static stiffness with high damping properties at a broad operating temperature and frequency range. Consequently, there are currently no industrially scalable processes for cost-effectively manufacturing high damping components. The HIPPOCAMP project addresses the development of a scalable industrial process enabling, (i) the synthesis of a new class of nano-composite materials, (ii) the production of these nano-composites on metal or polymer parts, to create industrial components with superior vibration damping property.",High-power Impulse Plasma Process Operations for the Creation of Advanced Metallic Parts,FP7,30 September 2016,01 October 2013,3699999.0 HIQNANOBIO,Imperial College London,health,"Highly sensitive biological detection opens new opportunities for biomolecular sensing. Label-free detection with high-Q microcavities is highly advantageous to perform label-free sensing due to its high sensitivity. We propose to develop a platform for multiplex label-free sensing with microring resonators. Close to the ring, we fabricate nanoscale pores (nanopores) for positioning control. This allows control of biomolecules position by electrophoretic force, without the need of surface immobilisation. Structures are designed to allow for multiplex sensing. The sensitivity is optimised thanks to the microrings properties as well as positioning and properties of the nanopores. Microring resonators are fabricated on a silicon-on-insulator substrate, using standard CMOS processing, allowing for cheap mass fabrication and integration with multiple sensing spots for real-time sensing in a lab on chip format. SOI offers a high refractive index contrast suitable for the fabrication of nanophotonic circuits including micron- and submicron sized optical cavities of very high quality. Solid-state nanopores are fabricated on Si3N4 membranes, using focused ion beam process. We also implement fluidic integration and optical set-up for multiplex measurement of resonant profiles. A tunable light source beam of wavelength l=1.3 micron is coupled in an input waveguide. It is further multiplexed to sense several rings in parallel. Translocation events through the nanopores induce a change of refractive index and therefore of guiding properties which may be measured through resonant response. Our technique allows performing biological sensing without the need of biomolecules immobilisation on a chip substrate. Biological tests are first carried out with DNA ladders for fragment sizing. We will then study potential of our platform for fingerprinting of proteins. It will open new opportunities to diagnosis applications as well as to study analytical measurements in complex systems.",Highly sensitive label-free detection using Nanopore and high-Q microcavities,FP7,31 July 2016,01 August 2014,231283.0 HISMAR,University Newcastle upon Tyne,information and communications technology,"This proposal will develop a multi-purpose inspection and maintenance platform with an advanced navigation system using Hall Effect and optical sensor technology for marine applications. The platform can be launched whenever the vessel is in port or at anchor. The device will be able to complete its tasks partially whilst in one port and be re-launched at successive points to complete the task. The generic platform will offer the option of using targeted plug-in modules to perform specific inspection or maintenance tasks such as structural integrity monitoring of the ships hull or carrying out cleaning and waste recovery operations.This project offers a means to effectively and efficiently undertake hull inspection and maintenance thereby extending the safe working life of the vessel. Cleaning of the hull ensures the vessel maintains the lowest possible resistance which has an extremely large impact on the hydrocarbon fuel consumed. Therefore ensuring a clean and smooth vessel surface reduces vessel emissions and reduces operating costs. The proposed dead reckoning method will use optical CMOS technology, which tracks surface feature changes. Because platform slip and drift can occur, it is necessary to use known hull features to update the current position. With a combination of Hall Effect and CMOS based optical sensors, it is possible to create a map of the structure for the vessel, which can be intelligently learnt, stored and recalled. By saturating the hull by a localised magnetic field, Hall Effect sensors can detect subsurface strengthening struts and other hull structural features, which will be used as unique landmarks. These landmarks will be used to continually and accurately update the dead reckoning sytem so that any drift or platform slip can be corrected. This landmark mapping of the ship's hull can provide 'teach and repeat' capability and be recalled at any time to aid the navigation of the hull.",Hull Identification System for Marine Autonomous Robotics,FP6,30 April 2009,01 November 2005,1200942.0 HISP,Swedish Defence Research Agency * Totalförsvarets Forskningsinstitut (FOI),transport,"The objective of this project is to significantly reduce the time, cost and mass required for spacecrafts to reach their destinations. This is directly linked to their propulsion systems. The only way to significantly improve the performance of a propulsion system is to develop propellants with higher specific impulse.",High Performance Solid Propellants for In-Space Propulsion,FP7,02 April 2016,03 January 2011,0.0 HISTORIC,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,photonics,"HISTORIC proposes to design, develop and test digital photonic integrated circuits containing a relatively large number of active photonic elements combined with passive elements, for use in e.g. all-optical packet switching for both datacom and telecom. The building blocks for the digital photonic circuits are ultra-compact gates based on micro-ring or micro-disk lasers, photonic crystal lasers or metallic nanocavity (or plasmonic) lasers. These lasers are fabricated making use of the heterogeneous integration of InP membranes on top of silicon on insulator passive optical circuits. Different approaches for the ultra compact lasers will be investigated, allowing to make use of the high precision growth and processing techniques available to the InP platform, as well as to take advantage of the extreme accuracy of state-of-the-art CMOS processing. Several all-optical flip-flops and gates will be integrated on a single chip, and will be interconnected by short wire waveguides in the SOI structure. The extremely small dimensions of both the flip-flops, gates and their interconnections will result in a competitive footprint of optical packet switches as compared with electronic switches. The targetted ultra small dimensions of the laser-based all-optical flip-flops are expected to result in record low switching times and switching energies. Together with the low propagation losses in the SOI waveguides, this is expected to result in a competitive speed and power consumption of optical packet switches. The possibility of integrating a large number of photonic digital units together, as well as integrating them with compact passive optical routers such as AWGs, opens new perspectives for the design of integrated optical processors or optical buffers. The project will therefore also focus on designing new architectures for such optical processing or buffer chips. Extensive characterisation and system tests will demonstrate the advantage of the new optical approach.",Heterogeneous InP on Silicon Technology for Optical Routing and LogIC,FP7,30 December 2011,01 July 2008,2300000.0 HIV,Aarhus University * Aarhus Universitet,health,"Conformational changes in bio-molecules are closely linked to their function and thus of major interest for an understanding of many biological processes. For a number of biologically active RNA molecules there are indications from biochemical assays that they are able to regulate their function by switching between different conformations of similar energetic stability. An important example is the RNA genome of the Human Immunodeficiency Virus (HIV), which is responsible for the AIDS disease, one of the most serious pandemics ever caused by a virus. Despite an intensive research effort the ultimate vaccine or drug against this disease has not yet been successfully developed. The difficulty related to this can be explained by the extraordinary high rate of genetic evolution of the RNA genome, which is related to a high mutation rate and a tendency of the RNA molecules to form dimers. The mechanism by which dimerization is initiated and regulated in the viral life cycle is not very well understood but is believed to be mediated by conformational changes in the RNA. The objective of the present project is to address in detail this issue with a new experimental technique, single-molecule fluorescence- resonance-energy-transfer (FRET) microscopy, which promises important new knowledge that cannot be obtained with traditional, ensemble-averaging methods. The activity proposed here is very much in line with the objectives of the Marie Curie Actions, implying the transfer of knowledge and promotion of European scientific excellence, and depending on interdisciplinary collaborations at the national and European levels. Furthermore, it can be classified as nanoscience as well as life science and biotechnology, all of which are declared priority levels of the European Commission.",Single-Molecule Analysis of RNA Conformational Dynamics in Human Immunodeficiency Virus 1(HIV-1),FP6,31 December 2004,01 January 2004,40000.0 HIVINNOV,Laboratoire BIODIM,health,"Highly active antiretroviral therapy is effective at controlling HIV-1 replication, however emergence and transmission of drug-resistant viruses is increasing, including viruses resistant to the newly developped integrase catalytic inhibitors. It is essential that new antiretrovirals (ARVs) become available. Most ARVs in development belong to the classes of viral enzyme inhibitors. Since HIV requires cellular cofactors for its replication cycle, we aim to develop novel classes of ARVs inhibiting specific virus-host interactions. Because host cell factors mutate rarely, this new class of ARVs should be less vulnerable to resistance. We selected two cellular targets, LEDGF/p75 and Transportin-SR2 (Trn-SR2), cofactors of Integrase (IN) and Capsid (CA) respectively, important for viral integration and nuclear transport. Partners of this consortium, R. Benarous, P. Cherepanov, A. Fassati and S. Emiliani, discovered, with others, these targets and elucidated their structure and function. Partner 1 SME BIODIM (FR), consortium leader, has developped small compound inhibitors of IN-LEDGF interaction. BIODIM compounds have a clear structure activity relationship, nanomolar ARV activity and are based on a new, structurally defined pharmacophore. The objectives of this project are to 1) Advance BIODIM IN-LEDGF inhibitors up to the proof of concept (POC) in man in a phase I/IIa clinical trial with partner 6 J. Gatell (SP) 2) Discover small compounds targeting the Trn-SR2 pathway in HIV-1 infection using a high throughput screening assay validated by partner 2 A. Fassati (UK), determine the pharmacophore by solving the 3D structure of Trn-SR2 with partner 3 P. Cherepanov (UK) and optimize the compounds up to the POC in a humanized mouse model of HIV infection with partner 5, B. Berkhout (NL) 3) Elucidate with partner 4 Emiliani/Saïb (FR) the network of interactions in which Trn-SR2 is involved with CA from uncoating to the pre-integration complex to provide new ARV drug targets.",Generation of a new class of antiretrovirals targeting HIV-cellular cofactors interactions,FP7,30 September 2015,01 October 2012,6000000.0 HJSC,Tel Aviv University,energy,"Light harvesting and the conversion of solar energy into other usable forms of energy is currently one of the most challenging topics on the field of renewable energy. Different possible scenarios exist to achieve this goal, some are based on solar thermal power and others on a variety of pathways for artificial photosynthesis. Perhaps the most promising approach is based on direct conversion of solar energy into electric current using photovoltaic cells. Needless to say, any significant advancement in cheap, accessible, photovoltaic technology will have a tremendous impact on the world energy economy. The overall goal of this proposal is to develop enabling technology needed to realize breakthrough photo-conversion efficiencies for nanostructured thin film photovoltaic systems. We will meet this goal through fundamental physical understanding of the kinetic and photo-physical processes involved in the conversion of solar radiation into useful electrical current for these systems. Building on this understanding will enable the development of new nanoscale materials, device structures, and interconnection schemes that will transcend the limitations of current devices providing for efficiencies to support new classes of all-inorganic solar cell devices. At the heart of the present program is the collaborative experimental (Berkeley host) - theoretical (PI) scientific effort. We believe that the field of renewable energy calls for such a close, fruitful, and fertilizing program. It will generate new ideas, thoughts, and directions required for a major paradigm shift in these systems. Furthermore, it will open novel directions for fundamental and applicable research for years to come.",Hierarchical Junction Solar Cells: Theory guides Experiements,FP7,31 July 2013,01 August 2010,337093.0 HK97 MATURATION,Aix-Marseille Université * Aix-Marseille University,health,"Virus maturation is virtually universal and allows the transition from an initially assembled non-infectious and fragile particle to a robust infectious virion. Siphophage HK97 is an accessible model system, to study assembly and maturation, for which intermediates can be isolated and myriad structural, biophysical and biochemical data are available. The capsid protein fold similarity between HK97, all other dsDNA bacteriophages and some animal viruses suggests that they share common maturation principles. The proposed project seeks to unravel the mechano-chemical reorganization program underlying the structural transitions observed during HK97 procapsid maturation using hybrid methods. It relies on a multi-disciplinary approach involving X-ray crystallography, electron microscopy and tomography to obtain multi-scale data ranging from atom to whole-cell. We aim to obtain structures of three different HK97 procapsid maturation intermediates to shed light on mechanisms involved in initial assembly of an energy-loaded particle as well as on forces driving forward maturation. We will also use electron tomography to study in vivo aspects of HK97 assembly and maturation in Escherichia coli infected cells. The outcome will allow apprehending mechanisms, dynamics and energetics of viral maturation as well as provide a basis for the use of HK97 as a delivery system for nano-medical applications.",Structural studies of HK97 bacteriophage assembly and maturation,FP7,31 August 2014,01 September 2011,232676.0 HOLIWOOD,Profactor GmbH,construction,"The goal of HOLIWOOD is the development and holistic industrial implementation of thermal treated hard wood.Two product lines are followed: -pre assembled load bearing walls for the construction of eco²building (incl. flooring) -noise protection barrier system With these products the technical and economic breakthrough will be targeted for thermally treated wood exhibiting superior properties in terms of durability and sustainability. By this way, energy and resource consuming materials such as concrete, aluminum and plastics will be replaced. The research and development activities focus on gathering basic know-how concerning the wood properties, paying special attention to statics, acoustics and manufacturing. The usage of Thermowood for load bearing construction parts is a technological innovation leading to a broad range of application in the house construction area. The integration into the construction of ecobuildings is a very promising approach for which the need has been expressed by leading architects. Beside the excellent properties, the market claims additional functionalities. The interdisciplinary approach of HOLIWOOD therefore additionally aims at the development of functional coatings. These nanocoatings shall base on modular design, offer ecological coloration and inhibition of the wood graying for more than 20 years. For indoor use the focus is on additional functionalities. The strong participation of SMEs demonstrates the importance of the investigated field of research in this traditional industrial sector. The consortium has been established based on an ongoing international project. Additional partners have been included to cover all necessary fields of R&D. Training and demonstration will prepare future costumers for the new products in due time. Exploitation strategies and demonstration activities complete the holistic approach in HOLIWOOD.For this purpose an eco²building and 1km noise protection barrier made of Thermowood","Holistic Implementation of European thermal treated hard wood in the sector of construction industry and noise protection by sustainable, knowledge-based and value added products.",FP6,30 June 2009,01 July 2005,5926722.05 HOLOVIEW,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The end of 'happy scaling' in the semiconductor industry has lead to innovation being a key parameter in nanoelectronics. Doped nanowires of all types of sizes, shapes and composition are now used as components to build nano-electronic devices, light sources, detectors and for photovoltaic applications. As these devices are reduced in size, the location of individual dopant atoms becomes more important and the behavior of only one or two atoms can dominate their properties. More recently, research into devices that contain a single dopant atom has begun to gain momentum. At this time there is no method that can routinely measure the presence of the single dopant atoms that are inside these devices and our experience in the nanotechnology age has taught us that we cannot make what we cannot see. In 2011, several review papers in high-impact journals have highlighted the need for a technique that can see these atoms. Their detection is now within reach, using a technique known as off-axis electron holography.",Single active dopant detection in semiconductor nanowires using electron holography.,FP7,30 November 2017,01 December 2012,1500000.0 HOT,University College Cork,photonics,"Tremendous developments in photonic crystals have recently taken place with very exciting possibilities for optics associated with metallic nanostructures. Our objective is to develop expertise in the physics and technology of metallic nanostructures at Tyndall through the transfer of knowledge from other experts in the field and to embed that knowledge in the existing research teams. By being trained in the theoretical methods and the technology for realising these structures, Tyndall researchers will be in a position to propose and realise the next generation of photonic materials and devices.",High performance optical and thermal properties of metallic nanostructures,FP6,28 February 2010,01 March 2006,801903.94 HOT SHOT,Imperial College London,health,"Almost 2 million people in Europe are diagnosed with cancer each year, over half of whom die within 5 years as a consequence. Cancer has been designed by the ESF as one of the priority targets for the development of new technologies. The side effects and poor efficacy of today's treatments mean there is a pressing need for new innovative multifunctional drug carriers able to specifically target tumours and decrease patient morbidity. HOT SHOT is a multidisciplinary project which proposes such a novel drug delivery approach based on highly engineered nano-materials. The drug carriers will consist of composite hydrogels made of protein-resistant polymer molecules cross linked together by rationally designed self-assembled peptide strands which can disassemble in response to stimuli such as defined temperature and pH transitions. Gold nanorods or nanoshells will be covalently bound to the termini of the peptide strands and embedded within the hydrogels. Thanks to the innovative design and attractive chemical and physical properties of the components, the drug carriers will possess notable properties: a) drug delivery specifically to tumours by means of enhanced permeability of tumoral vascular system to nano-sized hydrogel beads; b) drug release on demand or in response to exact local conditions (i.e. lower pH of the tumoral tissue with respect to blood); c) gold nanoshells and nanorods acting as contrast agents in tumour tomography imaging and d) as heat sources for tumour thermal ablation therapy when irradiated with near-infrared light. HOT SHOT will contribute to the creation of a multidisciplinary network of research groups within Europe in which the fellow will be embedded and experience excellent collaborations. It will provide the fellow with intense multidisciplinary scientific training and significant results in medical and engineering research and thereby an exceptional opportunity to attain professional maturity.",Rationally Designed Supramolecular Bio-inorganic Hydrogels for Tumour Therapy,FP7,14 February 2010,15 February 2008,169390.0 HOWTOCONTROLGRAPHENE,Universiteit Leiden * Leiden University,information and communications technology,"Conduction electrons in the carbon monolayer known as graphene have zero effective mass. This property offers unique opportunities for fast electronics, if we can somehow learn to control the dynamics of particles which have a charge but no mass. Fresh ideas are needed for this purpose, since an electric field is incapable of stopping a massless electron (its velocity being energy independent).",Search for mechanisms to control massless electrons in graphene,FP7,10 July 2015,06 January 2009,0.0 HPCNTW,University of Cambridge,information and communications technology,"Due to their unique molecular structure carbon nanotubes can offer high electrical conductivity and superior current density. Both of these properties are sought after, especially for overhead power transmission lines where the extremely high axial strength of nanotubes would also be a bonus. In this research proposal single wall carbon nanotubes (nanometer size tubes made of rolled up graphene sheets) with desirable dimensions and controlled way of the graphene sheet rolled up into a tube (referred to as chirality), will be synthesized and spun into fibres using two unique methods, which were developed in Cambridge. These high performance carbon nanotube fibres will be explored as flexible, lightweight, highly efficient materials for use as wires for a variety of power transmission applications.",High performance and ultralight carbon nanotube wires for power transmission,FP7,07 July 2017,08 January 2010,0.0 HQ-NOM,IMEP-LAHC Laboratory,information and communications technology,"The chief endeavor of the project is to develop, investigate and exploit systems associating nanoscale mechanical resonators with single quantum objects. Such combinations belong in the category of so-called “hybrid nanomechanical systems” which constitutes a rapidly expanding field in modern quantum- and nanophysics.",Hybrid Quantum Nano-Optomechanics,FP7,10 July 2019,11 January 2012,0.0 HSPILL-CEMA,University of Crete * Panepistimio Kritis,energy,"The objective of the proposed work is to synthesize catalyzed nanoporous materials that have superior hydrogen uptake between 300K and 400K and moderate pressures (20-100 bar) via the hydrogen spillover mechanism. Hydrogen spillover involves addition of a catalyst to a high-surface area microporous support, such that the catalyst acts as a source for atomic hydrogen, the atomic hydrogen diffuses from the catalyst to the support, and ideally, the support provides a high number of tailored surface binding sites to maximize the number of atomic hydrogens interacting with the surface. The proposed work will provide a means to explore an extended collaboration to combine in situ spectroscopic techniques and theoretical multi-scale modeling calculations. Carbon-based and microporous metal-organic framework (MMOF) materials will be drawn from past and on-going projects, so that the project will focus on identifying specific binding sites for atomic hydrogen and resolving the hydrogen spillover mechanism. Materials will be selected to explore the effect of catalyst size, material composition and structure, interface, and the potential role of co-catalysts on optimizing uptake via the hydrogen spillover mechanism. Materials will be characterized with in situ spectroscopy, and multi-scale modeling will be used to identify hydrogenation sites. Validated theory will be used to direct future material development. Identification of the key sites responsible for high uptake in select materials is expected to lead significant increase in capacity and reproducibility in hydrogen spillover materials that are optimized for near-ambient temperature adsorption.",Optimization of Hydrogen Storage via Spillover through a Combined Experimental and Modeling Approach,FP7,10 June 2013,11 June 2012,111241.0 HUMPHREY,University of Geneva * Université de Genève,energy,"In the last two years, nanostructures such as quantum dot superlattices have been experimentally demonstrated to have enormous promise as high efficiency thermoelectric materials, however why such high efficiencies can be obtained with these materials is not yet clearly understood. The applicant has previously demonstrated that nanostructured thermionic electron heat engines can operate with Carnot efficiency when the energy range of electrons transmitted through the device is infinitesimally narrow. In this project we will seek to demonstrate that a similar mechanism underlies the high efficiencies recently observed in nanostructured thermoelectric devices. Our approach will be to study a tractable model of a quantum dot superlattice thermoelectric device consisting of an array of one-dimensional quantum mechanical rings (the simplest possible quantum dots) in which inelastic scattering occurs by electron interaction with electronic reservoirs, following a technique developed by Buttiker. By identifying the underlying physical mechanisms for the high efficiency observed in nanostructured thermoelectric devices, we will answer questions which are of fundamental interest in theoretical condensed matter physics and thermodynamics, as well providing a 'road-map' for future experimental work in low-dimensional thermoelectrics.This project is extremely well aligned with the objectives of the IIF. The applicant is a 'top-quality' post-doctoral researcher working in condensed matter theory, who has so far been based in experimental groups. To continue to work at a high level in theory, the applicant would benefit substantially from a period of training with Buttiker, a internationally renowned theorist specialising in electronic transport in nanostructures. The applicant has 'hands-on' experience in both nanofabrication and theory, and is thus in an excellent position to facilitate future international collaborative projects between theorists and experimentalists.",Nanostructured Electron Heat Engines,FP6,31 August 2005,01 September 2005,179485.52 HWCVD,Universiteit Utrecht * Utrecht University,energy,"This conference deals with a new and exciting method to deposit silicon and carbon based materials, Catalytic Chemical Vapour Deposition, or Hot Wire CVD. It is an inherently cheap, and an amazingly fast and gentle method for the deposition of amorphous and microcrystalline silicon, diamond like carbon, and carbon nanotubes. The interest in this method is currently exploding worldwide. Bringing together in Europe experienced and young scientists from all over the world to interact in this exciting area will be beneficial to the thin film scientific community as a whole. Europe has the largest number of research groups that are active in this field, but advanced expertise is available overseas, in the USA and Japan. This conference will therefore be very effective, by bringing in overseas experts as well as many young researchers from Europe, including the Associated States. The conference will address the chemical deposition chemistry (including catalytic filament issues) and chemical and electronic passivation techniques, the thin films that can be obtained consisting of silicon possessing various nanostructures, epitaxial films, insulating films, and carbon-related films. In addition it will deal with the industrial implementation that is currently under study also in Europe, by demonstrating large area and economically interesting capabilities of the technique. The high deposition rate is of interest to the solar cell industry and the display industry. Also carbon nanotubes can be produced at high rate and conformai coverage by thin polymer layers, e.g. on biomédical applications, has been achieved. The lack of ion bombardment translates into superior surface passivation and significant noise reduction in electronic devices. The properties of many advanced materials are based on functional layers. It is the goal of this conference to understand why Cat-CVD can deposit high quality films at comparatively high rates, for #",Hot-Wire Chemical Vapor Deposition - Education of skills and cross fertilization,FP6,28 February 2005,01 March 2004,49450.0 HY-REM,University of Brighton,environment,Innovative approaches based on alloying of metals to remove mercury from drinking water will be developed. Gold and silver nanoparticles immobilized on the surface of silsesqioxane-hydride films deposited on silica-gel surfaces will be used as a novel adsorbent for trace mercury removal. Use of silsesquioxane-hydride as an additive for producing cryogels allows for creation of novel clean up devices for trace mercury removal from various environmental media. Incorporation of iron oxide nanoparticles in pores of silica-gel increase the specificity of the sorbent to arsenic removal.,Metal-containing hybrid materials for water remediation from trace heavy metals,FP7,09 June 2014,10 January 2010,171240.8 HY-SUNLIGHT,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Hopes for a new generation of photovoltaic technology (PV) which may overcome the limitations of the present semiconductor-based technology are based on organic materials, due to their light weight and broad absorption spectrum. In this respect, a special role is played by hybrid organic/inorganic nano-particles. Typical hybrid PV (HPVs) are composite films of semiconductor nano-particles (quantum dots) coupled to organic cromophores active in the visible range. Despite the strong efforts to improve efficiency and stability of HPVs to outperform standard inorganic cells, at present no theoretical/computational approach, going beyond heuristic models, is available to reliably describe the optical excitation of HPVs. These complex systems are untractable by present computational tools due to the very different nature of light-matter interactions in the different segments, leading the respective optical excitations to cover very different length scales. This situation is particularly unsatisfactory as the optical properties of hybrid organic/inorganic nano-particles may find ground-breaking applications in other applied field, notably nano-medicine and biology. The goal of the present proposal is to build the theoretical/computational background for a quantitative modeling of the light response of HPV. The specific objectives are i) a methodological advancement in HPV description, namely, the development of a genuine multi-scale computational method, based on a 'hybrid' Configuration Interaction approach, suited to deal with nano-hybrid systems; the new method should be able to describe excitations unique to, and delocalized over, the hybrid system in a nearly parameter-free approach, comparable to standard quantum-chemistry approaches which would not be applicable in this case; ii) the application of the new scheme to selected proto-typical systems of interest for HPV, and the conceptualization of the microscopic mechanisms of their optical properties.",Optical properties of hybrid organic/inorganic nano-particles for photovoltaic applications: toward a predictive computational approach,FP7,12 September 2012,13 September 2010,222272.0 HYANJI SCAFFOLD,Keele University,health,"This is an exchange-based programme to enable developing new tissue engineering scaffolds based. It aims at technology transfer of advanced methods from for the biosynthesis of polyalkaonates and for targeted drug delivery. The exchange programme comprises 2 EU partners (Keele and Pisa) and 2 Chinese partners (Tsinghua and Sichuan) who are centres of excellence. The exchange comprises 208 person-months over 4 years to achieve scientific and strategic development of foundation for long-lasting scientific collaboration between EU and China. Scientific novelty lies in the use of biosyntehsised multifunctional nano-process matrices. They will be cultured under dynamic conditions in bioreactor with online monitoring of O2, CO2, and pH. Building these regeneration constructs needs the combination of expertise which is by no means available on one ingle centre. The work is organised into definite but complimentary 4 work-packages (WPs) that are executed by the combined effort of the 4 partners. Each WP has 52 person months. After this project, each partner will have adapted new knowledge, skills and expertise resulting in new innovations in treatment of bone and cartilage defects to transfer to industry for and strengthened EU-Chinese collaboration to catch with existing gap with US and Japan.",Hyaluronan-based injectable material for tissue engineering (HYANJI SCAFFOLD),FP7,31 August 2013,01 September 2009,374400.0 HYBRIA,"Composites Research, Development and Application Centre * Fundación para la Investigación, Desarrollo y Aplicación de los Materiales Compuestos",transport,The use of composites materials for aircraft design allows integrating other different,Hybrid laminates. Industrialization for aircraft nose fuselage.,FP7,03 February 2015,03 March 2013,0.0 HYBRIDNANO,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,,Engineering electronic quantum coherence,FP7,12 July 2018,01 January 2012,0.0 HYBRIDSOLAR,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),energy,"Polymer-nanocrystal hybrid solar cells offer promise as a low-cost alternative to traditional solar cells due to their potential to combine the advantages of organic and inorganic materials to produce lightweight, flexible, and high-performance solar cells using low-cost solution processing. This project, which includes the first detailed synchrotron study of polymer-nanocrystal hybrid solar cells, will advance the understanding and performance of hybrid solar cells by demonstrating control of molecular packing and morphology in hybrid solar cells, correlating molecular packing and morphology with solar-cell properties and performance, and using the obtained knowledge to fabricate high-efficiency solar cells. The results will be of interest to researchers in a variety of fields and will be published in a series of high-impact journal articles and presented at materials science and chemistry conferences. The researcher will join the Solution-Processed Nanophotonic Devices (SPNP) group led by Professor Gerasimos Konstantatos at the Institute of Photonic Sciences (ICFO) in Castelldefels, Spain to complete this project. The SPNP group, an interdisciplinary team of physicists, chemists, and engineers, will share its knowledge of the design, synthesis, and modification of nanocrystals with the researcher. The researcher has extensive experience with organic solar cells and synchrotron characterization due to her research at the Stanford Synchrotron Radiation Lightsource (SSRL) as a PhD candidate at Stanford University and a postdoctoral researcher at Robert Bosch, LLC. The researcher will use her experience to perform the host group's first synchrotron experiments and form lasting collaborations with SSRL and ALBA, a third generation synchrotron source less than 40 km from ICFO.",Morphology and Molecular Packing in Polymer-Nanocrystal Hybrid Solar Cells Revealed with Synchrotron X-ray Characterization and Other Techniques,FP7,29 February 2016,01 March 2014,173370.0 HYBRIDSOLAR2010,University of Szeged * Szegedi Tudományegyetem,energy,"Heterojunction hybrid solar cells, consisting of an organic electron donor and an inorganic oxide semiconductor electron acceptor, have attracted much attention in the past decade. In this type of solar cell, photons are absorbed in the p-type semiconductor polymeric layer, and the generated excitons (holes and electrons) are separately transported within different nanophases, resulting in considerably large charge carrier lifetimes. An effective approach to building the heterojunction is to infiltrate the organic polymer into an oxide nanotube array (NTA) framework, which has several key advantages: (a) vertically aligned NTA affords pathway for vectorial electron transfer; (b) light propagation can be optimized by controlling the pore diameter, wall thickness, and nanotube length; (c) the NTA offers high surface area while maintaining structural order; (d) carrier collection is optimized by the proximity of exciton diffusion distances (5-15 nm) to the oxide nanotube diameter. Efficient infiltration from solution of a high molecular weight polymer into the NTA host can be challenging. In situ approaches are more attractive, either chemical or UV polymerization has been deployed to synthesize polythiophene derivatives in the oxide host. Intrinsic electroactivity of a monomer precursor molecule can also be exploited to electrochemically infiltrate the polymer in situ into the NTA. We presented the feasibility of this approach by using poly(3,4-ethylenedioxythiophene) and TiO2 NTA recently. The aim of this work is that by combining our knowledge on inorganic NTAs and conducting polymers, we can exploit the advantages of electrochemistry in order to achieve the fine tuning of the composition and morphology of the composites. By optimizing all key processes (light absorption, exciton generation, charge transport) we will prepare hybrids possessing improved photo-electrochemical properties. The best performing materials will be utilized to fabricate solar cell devices.",Development of inorganic / organic hybrid heterojunction solar cells,FP7,30 June 2014,01 July 2011,218744.0 HYBROQUBITS,University of Manchester,information and communications technology,"The proposed project is based on recent results reported (Nature 2009, 458, 314; J. Am. Chem. Soc., 2010, 132, 15435) by the Winpenny group where they showed that heterometallic rings could be grown around organic threads, producing a new form of rotaxanes with both inorganic and organic components. [3]rotaxanes could be made as prototypes for two qubit gates for quantum computers.",developing hybrid organic-inorganic rotaxanes for quantum information processing,FP7,04 June 2016,05 January 2012,0.0 HYCELT,Aston University,health,"This project, entitled 'Hybrid polymer-peptide hydrogels for Cell Therapy' (HYCELT) will produce cost-effective neuronal stem cell (NSC) scaffolds for central nervous system regeneration using a fibrous gel that has all the necessary requisites for fast clinical translation: cell-instructive, biocompatible, injectable and biodegradable. Finding a perfect methodology to heal spinal cord damage is a challenge of current times. Peptides are used for this purpose because they are biocompatible, biodegradable and will produce suitable gelatinous environments for cell growth at extremely low concentrations. The target of HYCELT is to demonstrate this technology in vitro, with follow-on work focussed on in vivo studies in appropriate animal models and in collaboration with clinical scientists to produce a global therapy that will change the lives of thousands of people suffering from irreparable spinal cord injury. HYCELT brings together a talented young fellow with a background in polymer hydrogels with an internationally blossoming group in polymer nanotechnology and well-established UK groups in peptide/materials science and biomaterials. HYCELTs multidisciplinary solution will exploit polymer-peptide hydrogel system also be applied in the vast field of drug delivery. Moreover as it will be developed in concert with Merck Serono (Italy), the biotechnology world-leaders in the field of therapeutics, it will be immediately applicable to living system. The supervisory team has been selected from experts at Aston, Sheffield and Merck (Rome) to provide a multidisciplinary training programme for the fellow and to ensure success of the ambitious research targets of HYCELT.",Hybrid polymer-peptide hydrogels for Cell Therapy,FP7,30 June 2016,01 July 2014,231283.0 HYCONES,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),energy,"HYCONES proposes the use of a radically new, leading-edge material, namely carbon cones (CCs), as a practical, inexpensive, lightweight, high capacity H2 storage medium, capable of storing/releasing above 6 wt.% H2 in a temperature window well suited for mobile applications. Carbon cones comprise a new form of carbon, fundamentally different from all the so far known carbon structures, which is produced in industrial quantities during the so-called Kværner Carbon Black H2 Process and is composed of carbon microstructures, which are flat discs and cones (appr. 20%). The CCs consist of curved graphite sheets, while five different cone angles have been observed, in accordance with the incurrence of one to five pentagons at the cone tips. Patented experiments clearly demonstrate unprecedented uptake-release of H2 unlike those for any other carbon material, as well as a new form of interaction between carbon and H2 (in contrast to conventional physi- and chemi- sorption), capable of releasing H2 at room temperature. This unique behaviour was explained after ad-hoc computational calculations, which indicate that due to the special topology of CCs, the system is characterized by unique electronic properties distinctively different from any other form of activated or nanostructured carbon, notably the fullerene family (including bucky-balls, single- and multi-wall nanotubes). Taking also into consideration the fact that the raw material can be produced economically in industrial quantities, HYCONES main target is to bring together a critical mass of instrumentation and know how resources and to focus its leading edge research potential in the development, characterization and modelling of this new ?unexplored? carbon form in order to develop a radically new H2 storage material with the potential to meet vehicle on-board storage requirements.",Hydrogen storage in carbon cones,FP6,31 October 2009,01 November 2006,1550000.0 HYDRA,University College Dublin,health,"The plan proposed for the two-year Marie-Curie fellowship aims at providing the applicant with the hands on experience and theoretical knowledge required to undertake an independent simulation activity in soft condensed matter physics. This is intended to complement the experimental activity on the same subject already carried out by the applicant Dr. Antonio Benedetto. Experimental and computational work will continue in parallel after the completion of the fellowship, providing a privileged basis for acquiring a leadership role in bio-physics soft-matter research. Training in computational methods will take place at Queen's University of Belfast, supervised by Prof. Pietro Ballone. The acquisition of modelling and simulation experience will be driven by the development of three different but related sub-projects, concerning: (i) the role of water in the equilibrium polymerisation of actin and tubulin; (ii) the interaction of room-temperature ionic liquids with lipid bilayers; (iii) the role of hydrogen bonding and hydrophobicity in the stabilisation of amyloid fibrils, with insulin as a prototype system. In all these problems, hydrogen bonding, hydrophobicity/hidrophilicity, and the dynamics of water molecules play the central role. Neutron scattering and simulation both represent powerful tools to investigate these properties, and their combination will provide a direct and microscopic view of the systems under investigation. Besides providing a comprehensive training in atomistic simulation to Dr. A. Benedetto, the three subprojects are expected to provide a wealth of important new results, with important implications for pharmacology, toxicology, environmental sciences, nanotechnology and medicine. The training and scientific work will be complemented by a series of outreach activities that are discussed in the application.",The role of hydrogen bonding and water dynamics in the self-assembly of proteins and lipids: a comprehensive experimental and computational investigation,FP7,31 August 2014,01 September 2012,191938.0 HYDROBOND,University of Barcelona * Universitat de Barcelona,energy,"The main objective of HYDROBOND is the development of a highly innovative process for application of superhydrophobic coatings onto large off-shore turbine blades, that will contribute to minimize the power losses and mechanical failures. Novel thermal spray technologies will be the way to achieve the nanostructured coatings with tailored anti-icing properties and enhanced bond strengh, in a cost effective manner for very large, composite material surface. The pursued scientific-technological objectives and impacts derived from HYDROBOND project are - Based on the properties of the new coatings, that will act as a passive anti-icing method, allow the design and construction of lighter larger wind turbines, avoiding the needs of heavier active anti-icing methods. - Due to the anti-icing properties, new coatings will allow the minimization of the ice accretion and will increase the reliability and operational life of components by reducing the mechanical failures. As already stated in this proposal, ice accretion will increase the load on the blades and on the tower structure, causing high amplitude vibrations and/or resonance as well as mass imbalance between blades, affecting specially the gearboxes whose lifetime is considerably reduced. - New anti-icing coatings will improve the cost/efficiency ratio of the blades, because ice accretion changes the shape and roughness of the blade airfoil significantly reducing aerodynamic properties of the blade resulting in power losses. - Due to the enhanced bond strengh and the ability to keep the anti-icing properties even when wear phenomena happens, will contribute on reducing the maintenance needs. The new developed process, being a portable one, will also contribute to reduce the maintenance cost of off-shore wind turbines allowing in situ repair.",New cost/effective superHYDROphobic coatings with enhanced BOND strengh and wear resistance for application in large wind turbine blades.,FP7,31 December 2016,01 January 2013,2929476.0 HYDROCAT,Queen Mary University of London,energy,"The goal of this proposal is the conversion of lignocellulosic biomass into both nanostructured materials as well as valuable chemical platforms for biofuels production. This will be accomplished in one single hydrothermal treatment step. The resulting nanostructured carbons will be used as heterogenous catalysts for the conversion of the bio-derived chemicals from the liquid phase into biofuels. We will particularly focus on the conversion of biomass-generated levulinic acid into levulinate esters, gama-valerolactone and valerate esters using low cost biomass-derived carbon catalysts. This will offer a closed cycle on biomass upgrade where both solid carbonaceous materials as well as liquid chemicals can be easily produced and further exploited for renewable energy purposes with zero emissions.",Hydrothermal Biomass Upgrade into Carbon Materials and Levulinic Acid for Sustainable Catalysis,FP7,28 February 2018,01 March 2014,100000.0 HYDROGEN,Universiteit Leiden * Leiden University,energy,"The introduction of the hydrogen economy requires breakthrough solutions for the production of hydrogen, and for on-board storage of hydrogen in cars. The network's aims are to achieve such breakthroughs through research, and to train a new generation of researchers in the skills needed for solving the problems associated with the introduction of the hydrogen economy. In performing the proposed research and through specific training actions, the network will train both early stage researchers (360 person months) and experenced researchers (138 person months). The first research goal of the network is to devise a tandem cell that can convert solar energy to chemical energy with an efficiency of 10%. To achieve this goal, a nano-structured electrode (consisting of iron-oxide, or another oxide), will be developed for use in a photo-electrochemical cell. The development will be based on an atomic scale understanding of the mechanism of photo-oxidation of water on metal-oxide surfaces, to be achieved through experimental and computational research. The second research goal is to find the best possible reversible hydrogen storage material, with a capacity of greater than 5 wt%. To achieve this goal, experimental and computational research will be performed on complex metal hydrides (alanates and boro-hydrides), and metal ammines. We aim at determining the atomic scale mechanisms that underlie catalysed hydrogen release and uptake, and reversibility. The network's researchers work in applied and fundamental physics and chemistry, and eight partners come from academia and two from industry. The interdisciplinary character of the network ensures the presence of the wide range of expertise needed to achieve breakthrough solutions and provide training on a European scope. The intersectorial character ensures that promising methods for production and storgae developed by the academic partners can be further developed and scaled up by th eindustrial partners.",Production and storage of hydrogen,FP6,28 February 2011,01 September 2006,3536726.0 HYGENMEMS,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,health,"The primary objective of the proposal is the development of a chip integrated hydrogen generator based on polymer electrolyte membrane water electrolysis with on-board hydrogen storage and an option for a bi-functional operation (as a unitized regenerative microfuel cell). The output of the generated hydrogen should be high enough to feed up to 50 mW.cm-2 microfuel cell at continuous operation, while enabling hydrogen storage capable to compete the conventional secondary batteries. The goal will be achieved by application of novel cost efficient nanostructured materials with enhanced catalytic activity and long durability, innovative technology for membrane electrode assembling based on microsystem processes, and precisely controlled reactant supply. The possibility for reverse operation of the system (as microfuel cell) will be addressed through deposition of composite bifunctional catalytic films and corresponding design modifications, including incorporation of hydrogen storage in the developed MEMS. The long term goal is the realisation of an integrated hydrogen generation–storage–power micro system for autonomous energy supply of wireless electronic devices. The host organisation (HO) has a high competence and internationally recognised achievements in the field of microsystem technology, proven by development and fabrication of variety of sensors, microfluidic, and medical devices. The researcher (R) is an experienced scientist with expertise in electrochemical material testing, electro catalysis, and hydrogen energy conversion. The competence of HO and R complement one another in an ideal way, building a strong basis for successful realisation of the project goals. The researcher will have excellent opportunity to acquire new theoretical knowledge and practical skills in the field of microsystem technology. These will promote the Researcher's future career and help her to establish a Microelectroichemistry Laboratory in Bulgaria.",Chip Integrated Hydrogen Generation-Storage-Power Micro System,FP7,16 December 2011,17 December 2009,231422.0 HYMEC,Humboldt University of Berlin * Humboldt-Universität zu Berlin,photonics,"The objectives of the project 'Hybrid organic/inorganic memory elements for integration of electronic and photonic circuitry' (HYMEC) are to resolve fundamental issues of materials science and to realize new hybrid inorganic/organic devices with functionality far beyond current state-of-the-art. This is of direct relevance to the objectives of the FP7-NMP Work Programme, as it calls for 'design novel knowledge-based smart materials with tailored properties, releasing their potential for enhanced and innovative applications'. Specifically, we will perform research towards understanding and controlling all relevant properties of systems comprising inorganic metal nanoparticles embedded in matrices of conjugated organic materials (organic semiconductors), and we will demonstrate the function of such material hybrids as non-volatile memory elements that can be addressed electrically and optically, which thus represent potential interconnects of future hybrid electronic and photonic circuitry. Moreover, we target implementing cost-efficient production routes, such as printing, as well as exploring the ultimate miniaturization of such memory elements by novel sublimation- and imprinting-based nanostructuring processes. Electronic, optical, dielectric, structural, and morphological properties of our systems will be determined using state-of-the-art experimental techniques and modelling to establish a reliable specific knowledge base, which we will exploit for device fabrication and integration. Through our cooperative efforts, we expect to make use of new knowledge for the realization of reliable non-volatile memory elements (NV-ME) employing resistance switching, with a substantial extension of existing NV-ME functionality, i.e., optical addressing of devices in addition to purely electric.",Hybrid organic/inorganic memory elements for integration of electronic and photonic circuitry,FP7,30 September 2014,01 October 2011,3132475.0 HYMEM,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,health,"The cell membrane is the biological platform for many vital processes such as photosynthesis, cell-cell contact, biomolecular recognition, endocytosis and ion transport. Artificial phospholipid membranes play an important role in unravelling the physical and chemical characteristics of membranes and their microscopic role in membrane function. On the other hand a manifold of novel hybrid nanosystems consisting of different nano-objects and exhibiting specific physical and chemical functions have been developed. This proposal aims at incorporating hybrid nanoparticle systems with specific optical functions into artificial and cell membranes in order to build up a nanophotonic toolbox for nanoscopic optical manipulators, local spectroscopic studies and the combination of both. This nanophotonic toolbox for membranes will open up novel strategies for the optical control of membrane function, the controlled optothermal release and lateral guiding as well as the local spectroscopy and analysis of biomolecules. The planned toolbox also contains new optical concepts for transfection and drug delivery.",Hybrid Nanosystems in phospholipid membranes,FP7,29 February 2016,01 March 2011,2368320.0 HYMM,Ce.S.I. Centro Studi Industriali Srl,information and communications technology,"The ever growing competition on the international markets pushes manufacturers towards shorter design cycles and decreasing manufacturing times and costs for their products. This trend generates a demand for smart, flexible and faster machining systems, easy to set up and configure, which are able to drastically reduce machining time, while improving the final accuracy. Machine axis acceleration of speed 3-5 times higher than conventional ones together with machining accuracy in the range of 0.5-1 µm will be the most probable targets of the new generation of machining systems inside manufacturing shops. Inertial forces, dynamic vibration and stability problems arising from such an accelerations will be so big that, if no suitable solutions are provided, the precision and machining quality will be definitely endangered. Strong mass reduction of mobile machine parts together with the increasing of their stiffness and damping to get excellent static, dynamic and thermal stability of the structures is becoming a 'must', to ensure a technological and cost-effective achievement of such an ambitious goals. Conventional materials for building machine tools are commonly cast iron, welded steel and in some case aluminium-alloy. Recently, especially in some running EU projects studies have been carried out to introduce polymeric matrix composites (PMC-fibers reinforced) materials, aluminium Honeycomb and glued structures. Even if good results in term of mass reduction and damping increasing seem to be achieved within such a projects, this will be absolutely not enough to get the declared excellent technological machine performances. The research will be focused on new materials for macroscale applications to reach a full and deep integration between structural and mechatronic parts of the machines in order to get an 'unicum' solution able to perform itself all the required functions.Therefore the primary goals is to achieve cost-effective'",Advanced Hybrid Mechatronic Materials for ultra precise and high performance machining systems design,FP6,30 June 2007,01 January 2004,1998600.0 HYNANO,King's College London,photonics,"Coupling of quantum emitters, and the exploitation of multi-photon quantum interference, is the next challenge for generation optical information technology and quantum computation. The aim of this proposal is to achieve long-range coupling of two or more quantum emitters, understanding the fundamental mechanisms of light transport, nano-optical emission control and resulting collective phenomena, such as super-radiance and lasing. A model system will be realised where the light originated from one quantum emitter is transported to the next one by a combination of photonic crystal waveguide and optical nano-antennas which together act as a bridge for light transport from the micrometer to nanometer scale.",Hybrid Nanophotonics for Enhanced Light Control,FP7,31 July 2016,01 August 2012,100000.0 HYPER,London School of Economics and Political Science,energy,"Photovoltaic (PV) solar cells promise to be a major contributor to our future energy supply, and the current silicon and thin film photovoltaic industry is growing at a fast rate (25 to 80% pa). Despite this however, only 10 to 20 GW of the total 15TW global energy demand is met by PV generated power. The ramping up in production and affordable global uptake of solar energy requires a significant reduction in materials and manufacture costs and furthermore, a solar industry on the TW scale must be based on abundant and preferably non-toxic materials. The challenge facing the photovoltaic industry is cost effectiveness through much lower embodied energy. Plastic electronics and solution-processable inorganic semiconductors can revolutionise this industry due to their ease of processing (low embodied energy), but a significant increase in performance is required. To enable this jump in performance in a timely manner, incremental improvements and optimisations (evolutionary approaches) are unlikely to provide sufficiently rapid advances and a paradigm shift, such as that described in this project, is thus required. HYPER is lead by Henry Snaith, a prominent young scientist developing hybrid and organic based solar cells. The project will create a new series of hybrid solar cells, based on photoactive semiconductor nanocrystals and light absorbing polymer semiconductors. At the core of the research is the synthesis of new semiconductor and metallic nanostructures, combined with device development and advanced spectroscopic characterisation. The central operational principle to be developed is long range energy transfer of photoexcitons from the bulk of the semiconductors to the charge generating material interfaces, maximising charge generation in these thin film composites Combined with this, advanced photonic structuring of the photoactive layers, and the introduction of nano-plasmonic light harvesting components will represent a new paradigm for hybrid solar cells.",Hybrid Photovoltaic Energy Relays,FP7,31 October 2016,01 November 2011,1870337.0 HYPER,Orion Innovations (UK) Ltd.,energy,"The proposed HYPER System is a scaleable and flexible portable power platform technology representing significant advances in terms of fuel cell development, hydrogen storage and associated supply. R&D will generate both new scientific knowledge and new technologies for exploitation. Specifically the project will: • Focus on developing a system based on application specific operational and performance targets, informed by early and ongoing end user intelligence; • Embed cost improvement and design for manufacture within the development pathway to optimise material and assembly costs and meet key cost targets; • Demonstrate complete application specific prototypes in the field with end users; • Deliver a market ready system that is flexible in design, and cost effective, for rapid roll out across multiple applications. The HYPER System can be readily customised to meet a range of application specific requirements including: power output, energy (or runtime), fuelling options, and cost (capex and opex). The system is based on a modular LT PEM fuel cell system with a common interface to use with alternative hydrogen supply modules. Two generic types of (interchangeable) hydrogen storage module will be developed: a bespoke gaseous hydrogen storage module; and a solid-state hydrogen storage module based on nanostructured hydrogen storage materials. Two proof of concept HYPER Systems will be developed and demonstrated; 100 We portable power pack/field battery charger, and a 500 We (continuous) range extender for a UAV. This will validate the scalability and robustness of the system whilst addressing early market opportunities that are aligned with the direct commercial interests of the Consortium Partners. The Consortium will provide a European supply chain, and early routes to market, for the subsequent commercial exploitation of the HYPER System.",Integrated hydrogen power packs for portable and other autonomous applications,FP7,02 September 2015,03 September 2012,2221798.0 HYPERCONNECT,IBM Research GmbH,information and communications technology,"Tomorrows micro-electronic devices will have to show more functionality and performance at smaller form factor, lower cost and lower energy consumption in order to be competitive on this multi-billion dollar market. Advanced system integration is thus inevitable, a trend bound to joining dissimilar materials with new packaging technologies. These processes must enable lower thermal resistances and higher interconnect density and device reliability under thermomechanical loading.",Functional joining of dissimilar materials using directed self-assembly of nanoparticles by capillary-bridging,FP7,12 July 2017,01 January 2013,0.0 HYPHONE,Technical University of Denmark * Danmarks Tekniske Universitet,photonics,"In recent modern optics, two rapidly developing branches can be identified: (i) photonics, which studies materials structured on a mesoscopic (micrometer or wavelength) scale, and (ii) optics of metamaterials, which are structured on a nanometer (deeply subwavelength) scales. In both these branches, revolutionary degree of control over light propagation and light-matter interaction has been achieved. However, they still remain relatively isolated fields of study. This project is aimed at developing a unified theoretical paradigm of hybrid multiscale photonics by combining the knowledge of photonics, plasmonics, and optics of metamaterials. It is expected that synergies between photonic band gap phenomena and exotic plasmonic excitations present in metamaterials will significantly enhance the possibilities for controlling the flow of light and tailoring light-matter interaction at the nanoscale. Central to the project are hybrid photonic/metamaterial systems where the elements (e.g., layers) are arranged in a periodic or aperiodic 'superstructure' and themselves contain metamaterials 'substructured' on a deeply subwavelength scale. The studies will start with simple geometries such as metal-dielectric multilayers with micrometer-scale superstructure and nanometer-scale substructures, moving on to more complicated 2D/3D systems based on nanowires and nanoparticle clusters. The resulting theoretical concept, applied to hybrid photonic/plasmonic/active systems (such as metal nanoparticle arrays embedded in polymer matrices doped with dye molecules), will be used to design novel plasmonic materials with low loss and/or optical gain. It will also lead to novel physical concepts such as random spasers or deterministically aperiodic photonic/plasmonic nanolasers, with applications in efficient on-chip frequency/polarization filtering, on-chip label-free sensing, and on-chip device-enhanced light-matter interactions.",Hybrid Photonic Metamaterials at the Multiscale,FP7,04 December 2014,01 October 2012,228082.0 HYPOMAP,Jacobs University Bremen gGmbH,energy,"Emission-free energy generation in mobile applications is one of the major challenges to science to reduce global warming. A particularly promising approach is the electrochemical oxidation of hydrogen in fuel cells. Two challenging questions have to be solved to achieve this goal: Hydrogen has to be stored at reasonable volumetric and gravimetric storage capacities in materials which allow efficient, energy-neutral loading and unloading. The released hydrogen must be oxidized electrochemically to produce electric power and water, the only by-product of this process. We will investigate various strategies to store hydrogen in nanoporous materials and by chemisorption in various hydrides. Special emphasis is given to the mechanism of adsorption, the thermodynamics of the ad- and desorption process, tuning of the materials etc. For studies on chemisorption, materials shall be searched with a suitable energy balance between hydride and dehydrogenated species. The reaction mechanisms will be studied in detail and tuning of reaction barriers by advanced catalysts shall be investigated. The studies include various known and advanced materials such as carbon nanostructures, metal organic framework materials (MOFs), covalent organic framework materials (COFs), boron nitrides, clathrate hydrates and metal clusters. While present fuel cell technologies are more advanced than hydrogen storage devices, there is still room for significant improvements. We will investigate new proton conducting materials for high- and low-temperature fuel cells, based on perovskites and new inorganic nanomaterials like imogolite derivatives (HT) and organic substances (LT). Investigations will include a wide range of theoretical approaches, including ab initio quantum chemistry, density-functional theory, quantum-liquid density functional theory for hydrogen, molecular dynamics and Grand-Canonical Monte-Carlo simulations",New materials for hydrogen powered mobile applications,FP7,31 May 2012,01 June 2009,899958.0 HYPONICK,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,manufacturing,"It is the aim of the project to enforce the technological position of European jewellery manufacturing industry and thereby improve competitiveness by developing innovative, low cost nickel-free undercoats for hypoallergenic gold plated jewellery by electroplating of nanostructured materials.The need to eliminate nickel emission from metal parts that are in prolonged contact with human skin for reasons of allergy is challenging the jewellery, eyeglasses, fashion accessories and watchmaking industry. To protect customers, the European Union has set out European Directive 76/769/EEC-12th Amendment (94/27/EC), effective from January 2000, which requires minimal nickel release from finished products over prolonged time periods. This has far-reaching consequences since nickel is traditionally used extensively both as an undercoat for gold plated articles and as an alloying element in casted gold. For the latter case, the nickel emission problem is solved by selecting alloys free of nickel. However, the nickel release problem has not been solved for gold plated articles. Jewellery manufacturers cannot fulfil customer demands by using technological alternatives offered present-day, since these have their distinct economic and/or technical drawbacks. Development of a real technological solution requires research work that jewellery manufacturing SMEs cannot afford due to size, lack of skill and high costs. The proposed technical solution to nickel replacement is created by combination of advancements in nanostructuring of electroplated films and jewellery electroplating technology. The innovative work focuses on two routes: synthesis of nanostructured base coatings that eliminate the need for additional barrier coatings; synthesis of nickel-free barrier coatings that can be applied on conventional base materials. Nanoparticle codeposition, pulse (reverse) technology and electrodeposition of alloying elements will be used to induce nanostructured under.",Hypoallergenic nickel-free (imitation) jewellery by employing nano-structured galvanic coatings,FP6,30 November 2007,01 September 2005,329720.0 HYSENS,University College Cork,photonics,"Functional organic molecules and metal and semiconductor nanocrystals represent attractive building blocks due to their composition-, size- and structure-dependent electronic properties, and the ability to design and manipulate these properties via low-cost and established chemical synthesis. Building from the pressing need of the European market to develop novel, scalable and cheaper technologies for sensing applications, the main objective of the HYSENS project is to exploit inexpensive organic functional molecules and inorganic nanocrystals as building blocks to synthesize novel high-knowledge materials for the development of sensors for Group I, II transition metal cations and anions (Cl-, NO3-). The hybrid material intelligence resulting from the engineered combination of individual units will allow the execution of logic functions able to reduce false sensing outputs towards the development of sensors with enhanced selectivity and sensitivity. Our goal is to elucidate the mechanisms governing the optical and electrical response of such engineered hybrid materials arising from the interaction between the organic functional molecule component and the inorganic nanocrystal core component. Establishment of component-function relationships will lead to disruptive new knowledge that will impact on optical and electrical sensors technologies.",Hybrid Molecule-Nanocrystal Assemblies for Photonic and Electronic Sensing Applications,FP7,31 March 2014,01 April 2011,3000000.0 HYSOL,Allnex Belgium SA,energy,"There have been major advances in the efficiency and efficacy of flexible electronic devices such as Organic Photovoltaics (OPV's) and Organic Light Emitting Diodes (OLEDS). Premature failure of the devices will occur through ingress of moisture and oxygen. Today there is however no simple, low cost process to create a 'barrier' to such ingress and extend device lifetimes. This project will investigate the structure–barrier property relationships in inorganic-organic hybrid coatings. The structures will be formed through the controlled self-assembly of nano-scale inorganic building-blocks synthesized through adaption of sol-gel chemistry. A variety of characterization methodologies including NMR, GPC, LC-MASS, DSC (Differential Scanning Calorimetry), WAXD (wide-angle X-ray diffraction), SAXS (small-angle X-ray scattering) will be used to assess the structures formed. Focus will be directed toward regimes of hybrid composition where the inorganic self-assembles as lamellae. Such structures offer the prospects of coatings which give both the high 'barrier' and the high optical transparency required in targeted applications. Cytec Surface Specialties, a chemical company, is the world leader in the supply of radiation curing resins for coatings and has the capabilities to formulate, apply, cure and test these hybrid coatings. The prospective fellow, Dr D Kogelnig, will have ample potential to expand his chemical skills from his previous work on the P/O/C based inorganic chemistry of ionic liquids to Si/O/C based chemistry required here and broaden his technical competences in polymer chemistry. His geographic transfer (Austria to Belgium) and from academia to industry is an example of genuine mobility. The training available would help him establish a career in Industry, but should he return to academia his experience will make his potential contribution from an academic environment all the more valued by industrial partners.",Inorganic-Organic Hybrid Materials through Controlled Self-Assembly of Nano-Building Blocks,FP7,31 December 2011,01 April 2011,163800.0 HYSPOD,Rijksuniversiteit Groningen * University of Groningen,energy,"This proposal aims at developing, studying the physical properties, and fabricating solar cell devices based on novel hybrid semiconductors. These new hybrids will combine the electronic properties of colloidal semiconducting nanocrystrals (nanorods) with those of semiconducting organic molecules. Semiconducting nanocrystals are confined systems and therefore are usually not good building blocks for electrical devices. The solution proposed by this ERC project to turn them into efficient components for optoelectronics devices is to build a functional interface between nanocrystals using organic molecules. This will allow extracting charge carriers from these confined systems by means of different physical phenomena including multiple exciton generation. The proposal thus aims to carry out fundamental research as an important step towards making solar cells an economically viable alternative source of energy. The execution of this highly challenging investigation will be based on multidisciplinary expertise in physics, device physics, and physical chemistry and delivered through three well defined, interconnected and targeted key objectives. i) The creation of a fully functional interface for semiconducting nanorods for the extraction of charge carriers; ii) the first fundamental investigation of multiple exciton generation with direct electrical measurement of the photo-excited carriers in these new hybrids based on nanorods; iii) the use of the new hybrid materials for the fabrication of highly efficient low cost solar cells. The applicant is well-established in this field, and has already achieved major breakthroughs in the design, study and fabrication of organic-inorganic hybrids. With the strong support of the Host Institution, she is in a perfect position to deliver on the ambitious goals of this proposal.",Hybrid Solution Processable Materials for Opto-Electronic Devices,FP7,31 December 2017,01 January 2013,1500000.0 HYSWITCH,Foundation for Research & Technology Hellas (FORTH),information and communications technology,"We will realize and model nanoscale Josephson field effect devices that will operate as single-electron hybrid superconducting nanoswitches. We will create three-terminal S-QD-S devices, ?Josephson quantum dots? (JDOTs), where the superconducting (S)source and drain contacts are connected by a quantum dot (QD) operating in the desirable but unexplored quantum confined (molecular) regime. Nanogates will enable very sensitive supercurrent tuning by controlling the QD charge state with single electron accuracy. By learning how to switch Josephson currents on/off simply by adding/removing a single electron, we will create a very sensitive coherent switching device. Compared to the state of the art, our JDOTs should allow for larger currents, higher switching sensitivity, lower power consumption, and scalability from 100 nm down to 1 nm. They could thus constitute elementary building block for non-dissipative nanoelectronics. To ensure success, we will explore and compare both carbon nanotube and semiconductor nanostructures. We will focus on the Coulomb-blockade and Kondo regimes and study on/off switching behavior, interplay between charge, spin, and superconducting correlations, and non-equilibrium effects. Our objectives are: 1) provide a proof-of-concept under ideal operating conditions 2) decide on which of the developed nanostructures offers the best potential for future applications. HYSWITCH brings together some of the leading experimental and theoretical groups in this field. It is built on a well-recognized platform of innovative achievements by the partners, which warrants the immediate undertaking of this high risk/high gain project. The new functions that may be achieved with the proposed devices can hardly be imagined within the existing paradigm of semiconductor epitaxy. This window of opportunity must be pursued vigorously if similar US-based efforts are not to leave the EU behind.",TUNABLE JOSPEPHSON DOTS,FP6,30 June 2009,30 December 2005,1750000.0 HYWIRE,University of Copenhagen * Københavns Universitet,manufacturing,"Semiconducting nanowires are a promising materials system for quantum information processing applications. Presently, there is much interest in using nanowires to support both spin qubits and, when contacted by a superconductor, Majorana fermions. The overall aim of the proposed research will be to develop the next generation of hybrid superconductor semiconductor nanowire quantum devices using ultra-clean InSb nanowires grown by molecular beam epitaxy. We will develop new device assembly techniques and sensitive charge detection schemes to explore and control single spin quantum coherence. Nanowire devices will be coupled to superconducting microwave resonators in order to demonstrate coherent spin-photon coupling and probe Majorana bound states.",Hybrid Nanowire Devices for Quantum Information Processing,FP7,02 May 2018,03 January 2014,221154.6 I-FLEXIS,University of Bologna * Alma Mater Studiorum Università di Bologna,photonics,"The target of i-FLEXIS is the development of an innovative, reliable and low-cost integrated X-ray sensor system based on heterogeneous inorganic, organic and hybrid components. It offers real time, direct X-ray detection, room temperature operation and a 'designed for industrial production' approach, delivering operationally robust and environmentally friendly devices surpassing current state-of-the-art sensors thanks to brand new and highly needed new functionalities like conformability, flexibility, large active area coupled to low weight, low power consumption, portability, optical transparency, recyclability and/or sustainable disposability (zero waste, according to REACH directives). i-FLEXIS integrates three major novel concepts, recently demonstrated as a proof-of-principle operation at laboratory scale, allowing for totally new sensing systems: organic single crystals as the active, X-ray direct sensing material, high mobility thin film transistors based on nm-thin films of novel high mobility oxide materials operating at ultra-low voltages and flexible transparent electronics, all integrated onto low cost plastic substrates. These new concepts, will be developed and implemented using micro/nanotechnology and will be integrated into the final well beyond-the-state-of-the-art sensor system that will consist of multiple sensing units integrated as a 2D matrix and will be scaled up to 10cm x10cm with printing techniques compatible with industrial production. The readout electronics for the whole system will be implemented by a CMOS platform based on printed organic and oxide TFTs. To validate the project outcome, the key-enabling technology of the i-FLEXIS system will be applied to two demonstrative contexts (test vehicles), to highlight its wide application potential:1) health diagnostic radiation sensor for bone density analyses and to determine the dose on the exposed area; 2) Identification tags to monitor the airport X-ray screening history of luggage",Integrated flexible photonic sensor system for a large spectrum of applications: from health to security i-FLEXIS,FP7,30 September 2016,01 October 2013,3863999.0 I-IMAS,University College London,information and communications technology,"The major abjective of the proposal is to develop a new generation of sensors that will create a break-through in the diagnostic quality of X-ray images in health, industry and security. The new sensors will incorporate technology that will enable adaptive imaging. Thes will lead to optimisation of the recorded information at the same time as minimising the radiation dose or duration of examination; in practice the ideal imaging system. These objectives closely match those stated in the Call FP62002-NMP-1 'to provide a new generation of sensors and systems for health, safety and security of people and the environment'. To develop this new I-ImaS technology the project is dicided into three phases. Firstly an analysis of the important cues to diagnostic information in an image and how these might be monitored by an inteligent sensor. Secondly, a phase where a new generation of CMOS sensors, the I-ImaS sensors, are designed and manufactures that incorporate the appropriate level of intelligence. Finally a quantitative evaluation of the success of I-ImaS technology when incorporated into an adaptive imaging system. The project will concentrate on two diverse and challenging medical imaging areas as a proof of principle. The consortium consists of an impressive team of scientists, end users and industrialists. Nine groups from five member states provide the critical mass and the necessary degree of complementarity in the key areas of sensors technology and applications. Each participant plays a vital role in bringing unique skills to the project. The strategic impact of the I-ImaS intelligent imaging approach is planned to be: * improved patient management and lower radiation burden for the population, and for the future * higher quality control in manufacturing industry with invreased throughput leading to less component failures and greater customer satifaction, and * total threat detection in security scanning with improved throught leading to a safer #","Intelligent Imaging Sensors for Industry, Health and Security - I-ImaS",FP6,31 May 2007,01 March 2004,2520020.0 I-PROTECT,PIB - Central Institute for Labour Protection * Centralny Instytut Ochrony Pracy,health,"The main objective of the 4-year project is to develop intelligent personal protective equipment (PPE) system that will ensure active protection and information support for personnel in high risk and complex environments, in particular chemical rescue teams, firefighters and mine rescuers, who are exposed to fire, explosions, high temperature, dangerous substances, limited visibility, high humidity and limitation of breathable air. These high-level risks are reflected in a significant number of injuries and fatalities reported in the target sectors. The S&T objectives of the project are: - to integrate, within the new PPE system, state-of-the-art materials, active textiles, optical fibre sensors, gas and temperature detectors, ICT - to develop new materials (based on nanotechnology) and integrate them into PPE elements in order to enhance multi-functionality and adaptability; - to assure ergonomic design of new PPE and validate its functionality, safety, comfort and performance level by usability tests in real working conditions. The project is divided into 4 phases: 1) Conceptualization; 2) Technical development and integration, 3) Verification and validation; and 4) Dissemination and exploitation. The consortium consists of 16 partners from 6 countries: 5 RTDs, 8 SMEs, 2 industrial companies and 1 non-profit organisation. Three partners representing target groups participate in the whole project to guarantee full adaptation of the PPE system to users' needs. The project will have an impact on: the reduction of occupational injuries and disease in the EU (the population of end-users estimated at 3-5 mln.); European regulations (PPE Directive) and harmonised EN standards; European leadership in PPE-related research and innovation; the growth of European PPE market and the development of ERA in the area of industrial safety.",Intelligent PPE system for personnel in high risk and complex environments,FP7,30 September 2013,01 October 2009,2726399.0 I-RISC,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"The ongoing miniaturization of data processing and storage devices and the imperative of low-energy consumption can only be sustained through low-powered components. Lower supply voltages and variations in technological process of emerging nanoelectronic devices make them inherently unreliable. As a consequence, the nanoscale integration of chips built out of unreliable components has emerged as one of the most critical challenges for the next-generation electronic circuit design. To make such nanoscale integration economically viable, new solutions for efficient and fault-tolerant data processing and storage must now be invented. The i-RISC project aims at achieving these goals, by providing innovative fault-tolerant solutions at both device- and system-level that are fundamentally rooted in mathematical models, algorithms, and techniques of information theory. Proposed solutions will build on error correcting codes and encoder/decoder architectures able to provide reliable error protection even if they themselves operate on unreliable hardware. The project will develop the scientific foundation and provide a first proof-of-concept by validating the proposed solutions on accurate error models and energy measurement tools developed within the project. In the forthcoming challenge of nanoscale technologies, the i-RISC project is an essential prerequisite for preparing the European industry for this paradigm shift.",Innovative Reliable Chip Designs from Low-Powered Unreliable Components,FP7,01 July 2018,02 January 2013,1613284.0 I-STONE,Pedrini SpA,energy,"The need for an IP (I-STONE) to address the current problems and the future requirements of the European Stone Sector originates from the ever increasing need of the EU Construction industry for more and higher quality stone products and the fact that despite its economic importance, the Stone Sector has not made any significant technological progress the last decades. The primary aim of I-STONE is the re-engineering of the stone production chain, in order to considerably increase its efficiency and productivity, minimise the amount of stone wastes disposed in the environment, produce a new generation of multifunctional products based on stone wastes and safeguard the quality in stone application and use. The ultimate target of the project is to transform the rather traditional Stone Sector into a modern, competitive and knowledge-based industry and ensure a lasting technological superiority of EU over its competitors. These objectives will be achieved with the incorporation of nanotechnology and intelligent manufacturing in stone processing and through the creation of new applicable knowledge and radical innovations in advanced materials and multifunctional products. The main radically new knowledge to be developed includes: the development of a new generation of consolidating agents with chemical characteristics similar to that of the stone, which will efficiently consolidate the stone products and prevent them from breaking during their processing; innovative extra thin cutting disks, a new generation of Ultra Fine Dispersed Diamonds and new heavy metal free metal-diamond bonds resistant to high temperatures and mechanical stresses that will lead to the development of innovative high-speed drilling and cutting tools to maximise productivity and new multifunctional products from stone wastes for construction applications with energy storage and self-cleaning properties.","Re-engineering of natural stone production chain through knowledge based processes, eco-innovation and new organisational paradigms",FP6,30 November 2008,01 March 2005,6759934.05 I-SWARM,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),health,"In classical micro robotics, highly integrated and specialised robots have been developed in the past years which are able to perform micro manipulations controlled by a central high-level control system. On the other hand, technology is still far away from the first 'artificial ant' which would integrate all capabilities of these simple, yet highly efficient swarm building insects.This has been the motivation of other research fields focusing on studying such swarm behaviour and transferring it to simulation or physical robot agents. Realisations of small robot groups of 10 to 20 robots are capable to mimic some aspects of such social insects, however, the employed robots are usually huge compared to their natural counterparts, and very limited in terms of perception, manipulation and co-operation capabilities.The proposed project aims to take a leap forward in robotics research by combining experts in both fields, micro robotics and distributed multi agent systems. The project aims at technological advances to facilitate the mass-production of micro robots which can then be employed as a 'real' swarm consisting of up to 1,000 robot clients. These clients will all be equipped with limited, pre-rational on-board intelligence. The swarm will consist of a huge number of heterogeneous robots, differing in the type of sensors, manipulators and computational power. Such a robot swarm is expected to perform a variety of applications,including micro assembly, biological, medical or cleaning tasks. Building on a large expertise in micro robot technologies, the project addresses topics like polymer actuators, collective perception, using (instead of fighting) micro scaling effects, artificial and collective intelligence. All the competencies required are available within the consortium. The project results will enable humans to further understand the micro world, bridge the gap between micro and nano technologies and be the stepping stone to a 'real artificial ant'.",Intelligent Small World Autonomous Robots for Micro-Manipulation,FP6,30 June 2008,30 December 2003,4397000.0 IAPETUS,Fundación Tecnalia Research & Innovation,transport,"Bonded composite patches are ideal for aircraft structural repair as they offer enhanced specific properties, case-tailored performance and excellent corrosion resistance. Bonding further eliminates stress concentrations induced from mechanical fastening of metal sheets, seals the interface, and reduces the risk of fretting fatigue between the patch and the component. IAPETUS focuses on the use of improved composite repair systems offering (i) the introduction of new on-aircraft simplified curing technologies, (ii) enhanced fatigue and damage tolerance properties and (iii) integrated damage sensing. This will be performed via the incorporation of carbon nanotubes (CNTs) both in the composite matrix of the repair patch as well as in the adhesive. The use CNT modified repair concept will lead to improved performance in the blunting of stress concentrations in the parent surface and the inhibition of crack propagation, leading to enhanced fatigue resistance at the locus of the repair as well as for the patch itself. At the same time, the patch repair acquires additional functionalities. The CNT doped Carbon Composites can be tailored to reduce the galvanic corrosion in repaired Aluminium structures. As the patch becomes electrically and thermally conductive thermal energy can be infused in the patch either by direct resistance heating (using the patch itself as heating element via the application of electrical voltage) or by induction heating, to instigate a uniform matrix polymerization since the patch system appears improved thermal conductivity too. The electrically conductive percolated network can be employed to assess the damage within the patch and its interface with the repaired structure, as conductivity changes mirror the damage in the doubler/substrate system by tracing micro damage through breaches in the CNT network; thus, the structural efficiency monitoring at any stage in the service life of the aerostructure can be assessed non-destructively.",INNOVATIVE REPAIR OF AEROSPACE STRUCTURES WITH CURING OPTIMIZATION AND LIFE CYCLE MONITORING ABILITIES,FP7,12 July 2014,06 January 2009,2339595.0 IASS,University of Salerno * Università degli Studi di Salerno,transport,"Inspection and Maintenance are important aspects when considering the availability of aircraft for revenue flights. Modern airframe design is exploiting new exciting developments in materials and structures to construct ever more efficient air vehicle able to enable ‘smart’ maintenance including self-repair capabilities. The improvement in the aircraft safety by self-healing structures and protecting nanofillers is a revolutionary approach that should lead to the creation of novel generation of multifunctional aircraft materials with strongly desired properties and design flexibilities. In recent years, the development of new nanostructured materials has enabled an evolving shift from single purpose materials to multifunctional systems that can provide greater value than the base materials alone; these materials possess attributes beyond the basic strength and stiffness that typically drive the science and engineering of the material for structural systems. Structural materials can be designed to have integrated electrical, electromagnetic, flame resistance, regenerative ability and possibly other functionalities that work in synergy to provide advantages that reach beyond that of the sum of the individual capabilities. Materials of this kind have tremendous potential to impact future structural performance by reducing size, weight, cost, power consumption and complexity while improving efficiency, safety and versatility. Actually, also a very advanced design of an aircraft has to take required inspection intervals into account. An aircraft with inherent protective and smart abilities could help to significantly extend the inspection intervals, thereby increasing aircraft availability. The main objective of this EASN endorsed proposal is to develop and apply a multifunctional autonomically healing composite for aeronautic applications. The multifunctional composite systems will be developed with the aim of overcoming serious drawbacks of the composite materials.",IMPROVING THE AIRCRAFT SAFETY BY SELF HEALING STRUCTURE AND PROTECTING NANOFILLERS,FP7,08 July 2017,09 January 2012,2397266.0 IBAHMA,University of Exeter,health,"Nowadays, safe archival data storage has become an urgent issue. The IBAHMA project concerns a new approach to providing ultra-stable (>50 years), ultra-high density (>1Tbit/sq.in.) data storage for archival applications, using ion-implantation to write nanoscale data into hydrogenated amorphous silicon carbide (a-SiC:H) films. Wide bandgap optical materials, such as a-SiC:H, when exposed to moderate ion doses develop useful optical contrast between regions of different irradiation levels. Absorption coefficient change of 1-2 orders of magnitude can be achieved by ion bombardment with chemically active species, like Ga+. The optical contrast formation mechanism is based on the ion beam induced structural and chemical modification of the implanted material, leading to considerable optical band-gap decrease and hence optical absorption increase. Furthermore, high-resolution digital (or analog) features of about 10 nm minimum size can be generated using focused ion beams (FIB), leading potentially to ultra-high storage densities. The use of Ga+ as an implanted species is of particular interest due to its widespread use in FIB systems and its relatively low melting point, which favours Ga incorporation as dispersed clusters or small nanoparticles in the host material. In this project, the precise nature of Ga incorporation into a-SiC:H films will be investigated, and the role of implantation conditions and post-implantation treatments on the achievable data density, readout contrast and data longevity will be investigated, and optimised conditions determined. In particular the precise role of temperature, both of the SiC 'target' during implantation and of post-implantation annealing treatments in determining the data storage characteristics (density, contrast, longevity) will be determined. The likely limitations for the practical application of this potentially very important new approach to data storage will also be assessed.",Ion Beam Applications to High-density Memory Archives,FP7,04 January 2012,05 January 2011,117213.0 ICARUS,University of Sheffield,photonics,"The proposed ITN will support close collaboration between 8 highly experienced and complementary European teams, who in all cases are working at the forefront of semiconductor science, photonics and materials technology. The real value that is offered by our collaboration will be realized by the generation of new, genuinely disruptive hybrid-semiconductor optoelectronic technologies. It will also train the next generation of scientists at the highest level, producing a skilled cadre of researchers who will contribute the Europe's competitiveness in emerging optoelectronic technologies. Our network has world-leading experience in the field of structure fabrication and material synthesis (both organic and inorganic), together with a strong focus in ultra-fast spectroscopy, nano-optics, photonics, non-linear optics and device engineering. We also have a significant experience in high-level theoretical analysis of the optical properties of organic and inorganic semiconductors, as well as experience in industrial research. The establishment of ICARUS will thus realize the creation of new hybrid systems, their characterization and their implementation in photonic and optoelectronic devices.",Hybrid organic-inorganic nanostructures for photonics and optoelectronics.,FP7,30 November 2013,01 December 2009,2803715.0 ICECLAY,"Active Aerogels, Unipessoal Lda.",construction,"40% of energy consumption and 36% CO2 emissions in Europe are directly related to the buildings due mainly to inefficient insulation materials and systems. Currently required insulation performance may only be achieved either by installing extremely thick ordinary insulation materials and sacrificing living spaces or by using unaffordable the state-of-the-art insulation materials (e.g. silica aerogel). Of European building sector, more than 99% are SME and buildings construction market reached over 1 trillion equivalent to about 9% of European GDP, representing a total workforce of 25 million jobs.",Highly efficient production of ultra-lightweight clay-aerogel materials and their integrated composites for building insulation,FP7,12 July 2016,10 January 2012,0.0 ICECOAT,University of Nottingham,transport,"Objective of ICECOAT project is to minimise the run-back icing over the natural laminar flow (NLF) wing surface by optimising the anti-icing coatings and electro-thermal de-icing system. This will help implement the laminar flow control technology currently investigated by Clean Sky Joint Undertaking. This objective will be tackled by a combination of four technical work packages, including Wettability and ice adhesion study (WP1), Development of smart anti-icing coatings (WP2), De-icing by electro-thermal system (WP3) and Validation of mixed strategies (WP4), together with Administrative work (WP0) and Dissemination/exploitation (WP5). The proposed work will be carried out by advancing our understanding of the heat transfer processes that determine runback icing accretion by fully considering the influence of both trapped air pockets and water within the developing ice matrix. We will also select and/or develop new types of coating matrices, new nanoparticles for nanocomposites, and new method for coating surface modification to produce anti-icing coating with higher hardness and erosion resistance. These new anti-icing coatings are tested in conjunction with an electro-thermal de-icing system, which will be optimised for its location over the wing. Pulsing operation of deicing system will also be tested to minimise the occurrence of run-back icing. Finally, the effect of laminar-to-turbulent transition of the boundary layer over the wing surface on the behaviour of run-back icing will be investigated in an icing wind tunnel.",Novel aircraft de-icing concept based on smart coatings with electro-thermal system,FP7,10 July 2017,05 January 2013,200000.0 ICFONEST,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"The ICFONest Post-doctoral program aims to provide high-level training and support for 14 outstanding international researchers in the early stages of their careers, working in the field of Photonics. ICFO will provide cutting edge facilities as well as a stimulating, international and interdisciplinary environment to help Fellows become successful independent researchers. ICFO currently hosts 20 research groups working in 50 different laboratories. Available to them are a nanofabrication cleanroom and a range of other support facilities. All research groups and facilities are located in a dedicated 10.000 m2 -building situated in the Mediterranean Technology Park in the metropolitan area of Barcelona. Currently, ICFO counts about 200 researchers, a number that is continuously growing. By 2014, when ICFO completes its ongoing expansion phase, the Institute will count more than 300 researchers working in 25 different research groups. Research at ICFO encompasses four broad thematic areas: nonlinear photonics, quantum photonics, nanophotonics, and biophotonics. Researchers work in a great variety of fields, including quantum information technologies, nanophotonic devices, remote sensors, optoelectronics, integrated optics, ultrafast optics, biophotonics, and biomedical optics. Projects are run as part of both medium- and long-term programs. The ICFONest COFUND program will run for four years and during this time it will support rising top-class researchers with excellent facilities, competitive salaries, research expenses and support from Group Leaders. During the period, the program will award 14 outstanding post-doctorate researchers with INCOMING Fellowships. ICFO will also offer specialised business courses and complementary training programs as well as a wide range of events, seminars and colloquia involving world-renowned scientists.",ICFONest International Postdoctoral Program,FP7,30 June 2015,01 January 2011,842900.0 ICONTROL,University Faculties of Notre-Dame * Facultés Universitaires Notre-Dame de la Paix (FUNDP),information and communications technology,"The ICONTROL project relates to the field of organic (opto-) electronic devices. We address the key components that determine device functionality and efficiency, i.e., the inherently existing interfaces between dissimilar materials in devices. The objectives of the project are: - Development of universal modification schemes for interfaces involving conjugated organic materials to achieve an unprecedented level of interface control. - Demonstration of applicability of these schemes in devices. - Transfer of these schemes to industrially relevant processing. - Generation of new insight into interfaces comprising organic materials, to provide a solid foundation for the future development of molecular electronics. Specifically, our schemes will allow for systematic and continuous adjustment of energy levels at virtually all interfaces, in order to provide: - optimized charge injection/extraction barriers at organic/electrode interfaces. - optimized energy level offsets at organic/organic interfaces. The common principle of our interface modification scheme is the introduction of oriented dipoles resulting from charge transfer reactions between specifically designed organic molecules and electrode materials, or between covalently linked donor/acceptor systems. The applicability of the new molecular materials that will be developed within ICONTROL is not limited to one specific interface-type. On the contrary, one new molecule will be useful to control the energetics at a wide variety of interfaces, making them true multifunctional materials. ICONTROL brings together 5 leading experts from 4 European countries, in order to combine the full expertise and line of actions needed to achieve the objectives of this multidisciplinary research effort: organic synthesis, electronic and structural interface characterization, theoretical modeling, device application, and transfer to industrial processes.",Interface-Control for Organic Devices,FP6,31 August 2009,01 September 2006,1649500.0 ICROS,University of Bristol,health,"The quest for an effective cancer vaccine was initiated over 100 years ago from the moment vaccines against infectious diseases were successfully applied, and despite the many advances to date, the search for therapeutic vaccines derived from carbohydrate antigens is still an ongoing challenge. Carbohydrate antigens of tumour cells are uniquely effective targets for antibody-mediated active and passive cancer immunotherapy and have also proven to be effective targets for immune recognition and attack. The gastrointestinal tract posses a protective epithelial barrier as part of the basic innate protective system, which produces a secreted mucus layer that contains hundreds of different mucin type O-linked oligosaccharides known to be connected with diseases such as breast and colon cancers. However, little is known about the specific role of this family of oligosaccharides in disease due to the lack of tools for study. Access to structurally defined complex carbohydrates is still a very laborious process and combinatorial approaches to prepare diverse libraries of oligosaccharides remain limited. A general automated method for oligosaccharide assembly will allow rapid preparation of structures of interest. This programme's long term aim is to develop carbohydrate-based cancer vaccines that elicit both a strong humoral- and cellular immune response against colon and breast cancers. To achieve our objectives, we plan to apply a novel and improved methodology (ICROS) to the synthesis of mucin type carbohydrate fragments, which are otherwise not available, ready to be immobilized onto nanocarrier systems for initial biological (antibody screening) and immunogenic assays. The understanding of these glycosylation patterns at both molecular and functional level will help us identify mucin oligosaccharide based antigens that will pave the way to the development of target specific anti cancer vaccines.",Cancer associated glycan epitopes via Ionic Catch and Release Oligosaccharide Synthesis (ICROS),FP7,29 February 2012,01 March 2010,172740.0 IDEA,TOPASS GmbH,health,"Regenerative medicine focuses on repairing or replacing tissue or organ function lost due to damage or congenital defects using appropriate cells for therapy that have healing capacities like stem cells or progenitor cells. Although regenerative medicine has the potential for more effective therapeutic interventions major improvement in three areas are still needed for a wider establishment of such new concepts in clinical practise: identification of the appropriate cells with healing capacity for the use in therapy, homing of these cells to the damaged tissue, and monitoring of the therapeutic intervention and effect. Thus, a multidisciplinary consortium has set up IDEA, a 60 month collaborative project to develop and establish: • Photonic methods that allow a contact and marker-free identification and selection of cells with healing capacity for vascular, musculoskeletal and neuronal tissue defects; • Magnetic cell select devices that capture and transport cells with healing potential through the circulatory system to damaged tissue and organs improving homing; • Tracer and imaging technologies to monitor the therapeutic effects of interventional regenerative medicine by showing anatomic structure AND demonstrating cellular function using magnetic resonance imaging (MRI) and a new imaging technology known as magnetic particle imaging (MPI). The IDEA project is intended to provide collaboration between scientists and clinicians from Karolinska Institute (Stockholm, Sweden), Kings College (London, UK), Paracelsus Medical University (Salzburg, Austria) and Julius-Maximilians-University (Würzburg, Germany) together with experts from SMEs specialized in photonic technologies for tissue engineering, medical device manufacturing with extensive experience in regulatory approval, the design, synthesis and up-scaling of nanoparticles for molecular imaging, and regulatory affairs. This multidisciplinary consortium will address scale-up, regulatory work and exploratory clinical investigations using the developed tools, technologies and devices in the time frame of the project.","Identification, homing and monitoring of therapeutic cells for regenerative medicine -Identify, Enrich, Accelerate",FP7,28 February 2017,01 March 2012,5897395.0 IDEA,University of Genoa * Università Degli Studi Di Genova,information and communications technology,"Extra-cellular recordings from excitable cell cultures using microelectrode arrays (MEAs) are now a well-accepted technique in both fundamental neuroscience research and applied electrophysiology. Nevertheless the current technological limitations restrict the mapping of spatio-temporal patterns capabilities of MEAs. In order to gain access to more detailed information on distributed processing, synaptic plasticity and spatially propagating activity patterns, the capabilities of recording the electrophysiological activity of increasingly complex electrogenic cell networks (i.e the MEAs mapping features) have to be upgraded. This requires the development of new high-resolution experimental tools. The aim of this project is to develop an enabling technology platform, based on an Active Pixel Sensor (APS) concept and signal and data processing algorithms for high spatial and temporal resolution recording and analysis of the electrophysiological activity of neuronal networks. The APS technology is used in CMOS cameras for example for fluorescence measurements. Our approach is based on changing the light-sensitivity pixel functionality to create a high-density array of metallic microelectrodes on a large active surface area. The APS-MEAs technology allows the integration of in-pixel and on-chip electronic circuits for signal amplification and high-speed addressing. The proposed technological platform together with the appropriate development of advanced signal and data processing algorithms will provide the scientific community a new validated experimental tool allowing to correlate local and intrinsic features at single cell and small neuronal network levels with global dynamic features of large assemblies of neurons.",Imaging device for electrophysiological activity monitoring of neuronal cell cultures,FP6,31 December 2008,01 July 2005,1399720.0 IDEE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"'Modern electronic devices play an increasing role in everyday life and have continuously increasing application domains. Electrostatic Discharges (ESD) and Electro-Magnetic Interferences (EMI) are increasing reliability concerns for electronic applications using advanced micro and nano-technologies. ESD failures are caused by the discharge of electrostatic charges present either on an external body, like humans or machines, or on the device itself. To cope with this problem, ESD protection circuits have to be provided at all pins of a device, to ensure that the discharge currents are safely conducted towards the ground. On the one hand, device susceptibility to EMI is measured by the maximum level of noise it can sustain up to operation failure or malfunction. On the other hand, a device can emit parasitic signal. Both noise emission and susceptibility of devices have to be minimized to obtain reliable applications. With the ever continuing scaling of technologies, the problem of ESD and EMI becomes more and more difficult to cope with since these technologies are more vulnerable to ESD and EMI with each new technology generation. New and original ESD/EMI protection techniques will be investigated in this project. A technology to build protection chips dedicated for ESD and EMI protection will be studied. It will take advantage of System in Package assembly techniques for the connection to the circuit to be protected. Moreover, new material having varistance properties and integrated in the final process phase (above IC) will open a new promising solution to overcome the limitation of current protection approaches in emerging technologies. The project will assist the applicant in professionally re-integrating his country of origin. The applicant will continue his career by joining the only academic research lab in France, involved in his research field, which has the full technology and characterization facilities to carry out this type of research.'",Integrated Dedicated Electrostatic discharge and Electro-magnetic interference protections for emerging-technologies applications,FP6,31 March 2008,01 April 2007,40000.0 IFOX,Stichting Katholieke Universiteit * Catholic University Foundation,manufacturing,"The goal of IFOX is to explore, create and control novel electronic and magnetic functionalities, with focus on interfaces, in complex transition metal oxide heterostructures to develop the material platform for novel ‘More than Moore’ (MtM) and ‘beyond CMOS’ electronics, VLSI integratable with performance and functionality far beyond the state-of-the-art. To this end it will:",Interfacing Oxides,FP7,05 July 2017,12 January 2010,0.0 III-V NWS ON SI,Technical University of Munich * Technische Universität München,photonics,"Apart from the never–ending miniaturization of higher–performance semiconductor devices, two major routes will be required to significantly push the Si semiconductor technology of today beyond its limits: the integration of low–cost Si technology with other high–performance materials and the use of new nanoscale device structures, where photonic and electronic units can exploit new functionalities via quantum physical effects. This project will merge these two important routes, aiming at the integration of III–V compound semiconductor nanostructures on Si for next–generation device applications. We will employ the gallium–arsenide (GaAs) compounds as highly efficient III–V materials due to their ultra–high carrier mobilities, superior optoelectronic properties and band gap engineering potentials. For nanoscale model systems we will incorporate these materials in the form of one–dimensional nanowires (NWs), which benefit from dimensions smaller than the emission wavelength, but also from their nearly defect–free singlecrystalline quality achieved via self–assembled growth. We will employ sophisticated molecular beam epitaxy (MBE) growth techniques to synthesize high–quality arsenide–based NWs on Si (111) via catalyst–free nucleation. The growth kinetics effects and selective area epitaxy will be directly correlated with extended materials characterization for optimization of structural, optical and electronic performance. Basic NW structures will then be extended toward advanced core–shell NW heterostructures for two complementary topics, (i) near–IR nanophotonic emitters with tunable–bandgap emission, and (ii) ultra–high electron mobility NW device structures, in particular field effect transistors (FETs). With detailed physical investigations and proof–of–principle demonstrations of such state–of–the–art device structures, we will provide significant insights toward the integration of nanoscale III–V heterostructures with Si.",Self-assembled growth of III–V Semiconductor Nanowires on Si for Future Photonic and High Electron Mobility Applications,FP7,30 September 2013,01 October 2009,100000.0 III-V-MOS,Consorzio Nazionale Interuniversitario per la Nanoelettronica (IU.NET),information and communications technology,"According to ITRS, III-V compound semiconductor n-type MOSFETs will reach production in 2018 as part of a new scaling scenario for high performance at very low voltage. The present lack of dependable TCAD models for the early stages of industrial development is a hindrance to benefit from the cost saves and time to market reduction that TCAD is recognized to deliver. To bridge this gap, III-V-MOS aims to provide to the European Semiconductor Industry accurate device simulation models and methods, integrated into TCAD tools, for successful introduction in CMOS technology of optimized device designs based on III-V MOSFETs at and beyond the 14nm node. III-V-MOS will develop, validate and transfer to industry a new device simulation methodology enabling the use of accurate quantum drift-diffusion and Monte Carlo TCAD tools. The models, calibrated by comparison with measurements on complete devices and ad-hoc test structures, will provide comprehensive descriptions of Ultra Thin Body Semiconductor on Insulator FETs, FinFETs and nanowire FETs at and beyond the 14nm node including device parasitics. A hierarchical approach will be used, starting from atomistic band structure calculations all the way down to customized TCAD simulation setups ready for direct use in an industrial environment.Systematic application of the new methodology under industrial guidance will provide new insight in nanoscale III-V semiconductor device physics and identify the potential of the technology boosters, thus substantially reducing the options to be explored for the device design and the corresponding costs. Future exploitation and high impact of the project results are guaranteed by the TCAD market leader (Synopsys); by a SME specialized in the growing business of atomistic simulations for technology development (QuantumWise); by a research center (IMEC) and an industry lab (IBM) engaged in CMOS fabrication technology development and by the European foundry GLOBALFOUNDRIES Dresden.",Technology CAD for III-V Semiconductor-based MOSFETs,FP7,10 July 2018,11 January 2013,2900000.0 ILNACO,Solvionic SA,health,"This proposal is targeted at the development of new functional Ionic Liquids, ILs, and polymeric ILs, which have special physical properties which make them very interesting, not only to chemists, but to industry as well. These new functional materials will be employed for the stabilization of nano-objects such as carbon nanotubes or metallic nanoparticles and its applications in the preparation of nanocomposites based on the last ones as well as the development of functional colloids for applications in catalysts. Thus, the proposed research will give an answer to the development of applications from technological/industrial point of view since both nanocomposites and fuctional colloids fields are major areas of research of ongoing interest. Achievement of the objectives will possibilize the development of new technological applications but also novel functional materials for high performance areas such as aerospatial, biomedical, nanotechnology and electronics. This fellowship will bring together a strong portfolio of skills from Dr. Maider Larrañaga, with excellent training opportunities, strong management, outstanding research outputs and high technology industrial research skills in complementary fields at the company SOLVIONIC. This will create a unique combination of expertises that will be beneficial to both parties, and that has not been proposed before. Research experience of Maider Larrañaga is mainly focused on nanocomposite area through the development of nanocomposites based on thermosetting systems and block copolymers/carbon nanotubes or inorganic fillers and block copolymers. SOLVIONIC is an expertise company in the production of novel multifunctional ILs, considered like green chemistry, centred in the development of two areas: catalytic processes for pharmaceutical industry and electro-chemistry industry. Together, this team will possess key skills and insight to deliver significant breakthroughs in the development of high performance materials.",Ionic Liquids on the Stabilization of Nano-Objects: Applications in Nanocomposites and Functional Colloids,FP6,17 October 2006,18 October 2006,157652.0 ILSES,University of Tartu * Tartu Ülikool,health,"This project aims strengthening interdisciplinary and technological collaboration between the scientists working in the topical areas of nanooptics and nanoplasmonics. These subjects investigate unique optical properties of nanoparticles and nanostructured surfaces, which are amazingly useful for improving optical materials, sensing bioorganic molecules, progress in solving of biophysical and biochemical tasks. Exchange by knowledge in such subject matter as giant Raman scattering (SERS), Surface Enhanced Infrared Absorption (SEIRA), metal enhanced fluorescence et al. is planned to organize in form of International Laboratory of Surface Enhanced Spectroscopy(ILSES). It is proposed to organize such laboratory by means of collective access to existing scientific equipment and technological achievements of partners using a system of mutual scientific journeys, meetings and workshops. From the viewpoint of applied science, the proposed partnership contributes to the extremely important and innovatively attractive field: the development of the new complex nanoparticle/bioorganical molecules and development of cheap and effective SEIRA and SERS nanostructured substrates. Since each partner brings its unique and specific expertise to reach the project objectives, the proposed partnership is very important, both for the area of collaboration and for the ERA as a whole. The main expertise of the participating teams cover different areas of present-day physics, biology and chemistry. Thus, the consortium joins scientists from several scientific communities under the common roof of the interdisciplinary research on metal nanoparticle interactions with bioorganic molecules. In addition to the interdisciplinarity of the teams, young scientists are to be widely involved which will allow a sustainable dissemination of knowledge. Thus, besides the scientific results, the project is expected to bring new research experience for young participants unavailable at home institutions.",Metal nanoparticle interactions with bioorganic molecules and their applications in biosensing,FP7,31 July 2017,01 August 2013,196100.0 IMAGINDNA,IMDEA Nanoscience Institute * IMDEA Nanociencia,health,"Fluorescence microscopy is one of the most convenient and widespread tools used in the life sciences. An important challenge, however, is to improve its spatial resolution, which is limited to about 200 nm. Recent 'super-resolution' techniques such as photoactivation-localization microscopy (PALM) can provide images with a spatial resolution of tens of nm. Most studies performed with these techniques have imaged the nanoscale distribution of proteins. However, little progress has been seen on DNA super-resolution imaging due to challenges in labelling. My main research is aimed at exploring new ways to label DNA in high density with photoswitchable fluorophores and improving spatial resolution in fluorescence microscopy. This will allow opening up new opportunities to study a broad range of problems in Biology and Nanoscience. My recent work has shown that PALM-like imaging of DNA can achieve a spatial resolution below 40 nm by using intercalating cyanine dyes in combination with a buffer that promotes photoblinking. This proposal aims at optimizing this approach, and at finding new alternatives for DNA super-resolution imaging. I propose two research lines: 1) Use correlative atomic force microscopy and PALM-like imaging to optimize the above methodology. As first targets, DNA origami will be used. Correlative microscopy will then be applied to study chromosome structure; 2) Study the photophysical properties at the ensemble and single-molecule level of a new material, CyDNA (DNA highly substituted with cyanine dyes in a controllable way). Bringing together Cy3 and Cy5 dyes in the same CyDNA with high density results in a photoswitch with new properties. CyDNA photoswitching will be used for super-resolution imaging in combination with fluorescence in situ hybridization, and also to improve image contrast with optical lock-in detection imaging. Further opportunities to apply the developed methodology will also be identified throughout the fellowship",Advanced DNA imaging: improving spatial resolution and contrast through photoswitching,FP7,31 January 2017,01 February 2013,100000.0 IMAGINE,The University of Edinburgh,information and communications technology,"Future developments in the control, functionalization and manipulation of magnetic nanoparticles and nanoscale magnetic devices require an understanding of collinear and non-collinear spin configurations and correlated changes of electronic structure on the sub-nanometer scale.",Imaging Magnetism in Nanostructures using Electron Holography,FP7,03 July 2020,04 January 2013,0.0 IMANILBCAT,Tel Aviv University,health,"The current research proposes new optical spectroscopic and interferometric microscopy and nanoscopy techniques for accurate measurements and visualization of biological cell structure, organization, stiffness and dynamics by recording the cell spatial, temporal, and refractive-index structure on sub-wavelength and sub-Hertz scales. The following objectives are proposed: (a) Novel optical-mechanical signatures of cancer cells measured by wide-field digital interferometry: I propose to establish multi-disciplinary cancer biomarker using the stiffness signatures of cancer cells measured in a noncontact, quantitative and label-free manner by wide-field digital interferometry (WFDI). (b) Interferometric and spectroscopic diagnosis of red blood cell diseases: I propose to measure mechanical and morphological properties of live red blood cells (RBCs) with extremely high sensitivity in a non-destructive, noncontact and label-free manner, as a mean to learn about the biomechanical properties of the RBC membrane and as a novel diagnosis tool for diseases that change morphology and mechanical properties of RBCs. (c) Developing plasmonic-nanoparticle-based interferometric methods for Alzheimer's disease research: I propose to develop new nano-sensing and imaging modalities as a means to monitor degradation of neuronal function due to Alzheimer's disease. I will use photothermal optical coherence tomography with nanoparticles bound to amyloid beta to detect the degeneration in neuronal activity. This system will be combined with a low-coherence WFDI system for quantitative phase imaging of rapid dynamic neuronal phenomena. The proposed objectives are highly interdisciplinary, involving optical engineering, sensing in biological systems, biophysics, nanoscience, neurobiology, and disease research, and have a great potential of providing new means for diagnosis and monitoring of diseases in the sub-cellular level, as well as aiding in identifying new avenues for therapy.",Interferometric Microscopy and Nanoscopy in Live Biological Cells and Tissues,FP7,31 March 2016,01 April 2012,100000.0 IMAT,University of Florence * Università degli Studi di Firenze,health,"The IMAT project aims to integrate the cutting edge research in nanotechnology with that of cultural heritage conservation for the development of new advanced conservation techniques and materials. A consortium of researchers representing expertise in the areas of art conservation, nanotechnology, and thermo-electrical engineering, has been assembled with the purpose of inventing an advanced precision heating technology and designing a series of portable, highly accurate flexible mild heating devices specifically for broad application in the field of art conservation, employing, but not limited to the new technology of carbon nanotubes (CNT). The new technology and product acknowledges and responds to a glaring omission in fundamental conservation instrumentation. The control over the application of heat often constitutes the core of success in structural treatment of diverse cultural heritage objects, yet sources currently available to conservators are unable to guarantee accuracy, control or uniformity, and therefore may compromise the favourable outcome of treatment. The lack of mobile high precision and accessible instrumentation impacts conservation treatment capacities and the long-term preservation of irreplaceable cultural heritage in the most direct way, since objects may be and are exposed to risk because of inadequate or unavailable instrumentation. This is particularly relevant to treatments that take place in the field, including emergency responses, that often must rely on inadequate tools. The heating table, long considered a basic piece of laboratory equipment for previous methodologies, is now out of sync with the current direction of conservation that favours minimally invasive treatments with respect to those of the past and requires enhanced mobility and versatility. The IMAT goals therefore will hit the core of this problem in many ways and the results will have a lasting impact on conservation methodology and beyond. The unique properties of carbon nanotube (CNT) materials will allow for the design of thin, lightweight, even transparent, stretchable and woven mild heaters with low power needs as an ultra-portable, versatile and efficient alternative for diverse thermal treatments. The development of the IMAT device and methodology will represent a unique opportunity to impact the field of conservation of heritage products in a significant manner, and the full extent of the potential for application will become evident only during the execution of the three-year project. Further application of the technology to fields outside of art conservation, such as art transportation, medical field, aeronautics, car industry, apparel industry and more will be investigated. The project was conceived with a research-based objective, focusing on the creation of the IMAT device in order to improve the quality, accessibility and cost effectiveness of a fundamental tool for art conservators in Europe and globally.",INTELLIGENT MOBILE MULTIPURPOSE ACCURATE THERMOELECTRICAL (IMAT) DEVICE FOR ART CONSERVATION,FP7,31 October 2014,01 November 2011,1807545.0 IMAX,Universiteit Twente * Twente University,information and communications technology,"Local modifications of materials with X-ray beams have recently been shown feasible by the researcher of this application in exemplary high-Tc superconducting copper oxide materials. These modifications are not based on materials degradation by the creation of structural damage, but rely on ordering of defects such as oxygen vacancies and interstititals, which can even lead to materials improvements, in this case Tc enhancements. These modifications can be realized locally by micro X-ray beams and therefore shapes can be drawn at will in two dimensions when the X-ray beam is used like a pen. The structures could also be erased again by applying heat treatments. Here we propose with the Intra-European Marie Curie Fellowship to join this expertise of the researcher with the various advanced thin film materials science and nanotechnology techniques available at the University of Twente to further explore the potentialities of this X-ray manipulation for relevant nano-materials. Concomitantly, it will provide the researcher with very valuable training in such areas as materials fabrication, advanced microscopy and nanolithography. Selected thin film complex oxides and their heterostructures, e.g.. SrTiO3-LaAlO3 stacks, graphene and chemical derivatives of graphene will be used for the manipulation through the use of X-rays at synchrotron radiation facilities and in laboratory sources. As a special type of structure, we will look at fractal patterns, which were discovered earlier by the researcher to be a route towards a Tc enhancement in the cuprates, and for which also for the electronic transport properties in non-superconducting materials interesting theoretical predictions have been made.",Improvement of MAterials with X-rays,FP7,10 July 2017,11 January 2013,175974.6 IMBEING,Gdansk University of Technology * Politechnika Gdańska,information and communications technology,"This proposal intends to deliver a basement for networking, staff exchanging and joint seminars and workshop between partners, who all deal with the problem of tribology aspects of micro-bearings including friction and lubrication of micro-pairs and friction of micro-joints in conical, spherical, cylindrical, parabolic and hyperbolical micro-bearings. The aim is shaping a focus group for further cooperation and joint scientific researches in the mentioned field.",Towards Intelligent Micro-Bearings – Tribological Aspects (IMBeing),FP7,01 January 2017,01 February 2014,0.0 IMCOSS,Ceramisys Ltd.,health,"The repair and regeneration of bone tissue remains a significant clinical challenge in many clinical fields including orthopaedics, dentistry, and maxillofacial surgery. The problem is increasing in the face of complicating factors such as the ageing population. The aim of this project is to undertake a basic scientific study of new nanostructured biomaterials that will underpin the development of new nanostructured, injectable bone graft substitutes. This scientific and technological research will be integrated with the development of a dedicated advanced delivery system that will provide the surgeon with a high degree of control during clinical use. The basic scientific research will be directed at understanding structure-property relationships related to nanoparticle size and morphology, composition, and functional behaviour including rheology, biocompatibility, and bone tissue regeneration. While the project is ambitious, the likelihood of success is greatly increased by the formation of a consortium that includes different elements of the supply chain in combination with the scientific competencies necessary to execute the work programme. The scientific and technological aspects of the project will be further enhanced by the participation of a clinical panel composed of surgeons from the two RTD partner organisations. This combination of business, scientific and clinical expertise will together facilitate the translation of basic science through applied research and on to development of a new medical device.",Injectable Medical Ceramics for Bone Repair and Augmentation,FP7,30 November 2014,01 December 2012,1443000.0 IMECHIGHK,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"In the semiconductor industry, the scaling of MOSFETS ensures the continued reduction in cost and increase in speed. The gate dielectric plays a critical role in this scaling, and extensive research has been carried out on the subject of how to increase the lifetime and integrity of these layers as they become thinner and are subjected to ever increasing current densities and electric fields. The need for a `high-k layer which can be fabricated thicker (while giving equal performance) to replace SiO2 as the dielectric layer in scaled MOSFET devices to stem the leakage current problem is evident. In this project, we intend to refine test methodologies developed by IMEC on relatively well understood high-k candidates like HfO2 and apply these methodologies to more novel materials eg La2O3. The test methodology will focus on controlling the flatband and threshold voltages, Vt shifts, channel mobility, bias temperature instability, charge formation, trapping and amp; de-trapping, and interfacial kinetics for HfO2 films. Electrical measurements will be made on both large and small area capacitors, and on MOSFETs, and special attention will be paid to understanding the different properties of large and small area devices. Subsequently the study will be extended to new materials and these properties will be evaluated in newer high-k candidates, in an attempt to understand the physical mechanisms at work. Another aspect of the project will be the correlation of the electrical data to physical analysis. This will be achieved by the use of materials analysis techniques (SIMS, XPS etc.) to determine chemical environments, and the linking of this data to electrical performance. The goal of the project is to develop a methodology for evaluating the suitability of high-k materials for incorporation into CMOS, and ultimately to identify such a material.",An Advanced Electrical Characterisation study of Alternative Gate Dielectrics: The Effect of Charges and Defects on Material Properties,FP6,29 October 2008,30 October 2006,144021.0 IMMUNANOMAP,Stichting Katholieke Universiteit * Catholic University Foundation,health,"The major objective of IMMUNANOMAP is to rain the next generation of multidisciplinary researchers to operate at the intersections of nano-technology, nano-chemistry, molecular cell biology and immunology. Interdisciplinary researchers are needed to develop tools and insights into our molecular understanding of the cell as a central entity of all living organisms and unravel the mechanisms underlying the defence against pathogens. Novel microscopic techniques now provide the tools to cell biologists and immunologists to study cellular processes at the nanometer and single molecule scale. Particularly in the immune system, which defends our body against pathogens, the recognition and elimination of nanometer-sized pathogens is regulated through complex cell signalling to ensure a swift and effective protective response. How these cell surface processes are orchestrated is poorly understood. For the first time, the technology is within reach to unravel the nanolandscape of surface receptors of cells of the immune system and get dynamic information of their organization and subsequent signalling pathways at the nanometer level. We hope to reach out goal by: 1) thorough multidisciplinary training both at the theoretical and practical level to a truly interdisciplinary field of young and experienced researchers consisting of physicists, surface chemists, cell biologists and immunologists, and 2) exploiting state-of-the-art imaging techniques to understand the molecular organization of cell surface and signalling processes pertinent to the functioning of the immune system. Thus we anticipate eliminating a major limitation in multidisciplinary work that restricts scientific and economic progress due to fundamental differences in the background of scientists in these diverse disciplines. To achieve this, 7 renowned research institutes and 1 SME, each specialized in different aspects of bio-nanotechnology, join forces in this European research and training collaboration.",Unraveling the nanolandscape of receptors controlling molecular processes of the immune system,FP6,28 February 2011,01 March 2007,2960000.0 IMPLANT,University of Bristol,health,"This interdisciplinary proposal will investigate whether the activity of a unique family of membrane transport proteins can be harnessed to develop novel strategies for the bioinspired fabrication of nanoscale materials and provide new directions in synthetic biology. Silicon transporters (SITs) are integral membrane proteins that were first identified in the diatoms, single–celled eukaryotic algae that surround themselves with a cell wall of hydrated silica. The biosynthesis of this 'glass house' depends upon the uptake of silicic acid, the soluble form of silica, from the environment. The SITs bind silicic acid with high affinity and transport it across the cytoplasmic membrane into the cell. Under this proposal the SITs will be recombinantly expressed and purified before being reconstituted into synthetic liposomes. The resulting proteoliposomes will be energized to drive SIT-dependent transport of silicic acid into the interior lumen. Since the lumen has dimensions on the nanometer length scale and attolitre volume, the proteoliposomes will act as discrete nanoreactors for the synthesis of silica nanoparticles. Using SIT proteins to deliver silicic acid to the growing nanoparticle offers an unprecedented degree of tunable kinetic control over the synthetic conditions that, together with the lumen microenvironment, may induce novel particle morphologies or properties. This principle will be extended in two further directions. First, encapsulating preformed inorganic nanoparticles in the liposome lumen will lead to the formation of core-shell nanoparticles with a functional core and passive silica shell. Using SITs to control the supply of the synthetic precursor will provide unparalleled tight control over the thickness of the silica shell. A second element will create a diatom protocell by incorporating silica-condensing peptides into the lumen in order to generate silica nanostructures. This will establish a unique new methodology for nanoscale synthesis.",Silicon transport proteins in biological nanoscience and synthetic biology,FP7,30 September 2016,01 October 2011,1487476.0 IMPRESS,Cardiff University,health,"IMPRESS targets the development of a technological injection moulding platform for serial production of plastic components incorporating micro or nano scale functional features. The platform will be based on the gathering of up to date and most advanced facilities based on three main modules, each of them being a tool box including several building blocks: - a tool manufacturing module involving different technologies of micro- nano direct manufacturing, from top-down to bottom-up such as self-assembling, - an injection moulding module including equipments fitted with up to date hardware to improve replication quality and capability, - an intelligence module dedicated to advanced process control and online metrology integration. Beside this large panel of facilities, three case studies have been selected (biology, health and energy), each of them requiring a specific and well defined surface micro-nano texturation. These case studies cover a very large range of nano-feature (from 100nm up to 1 µm) and component size (from 1 cm2 up to 1000 cm2). They will serve to qualify the capabilities of the different building blocks and will allow (i) to select the most suitable building blocks as of application requirements (ii) to learn about the platform working and (iii) to anticipate the technological future of the platform. Finally, a technico-economic tool for decision making will be developed based on the IMPRESS case studies and thus to allow end-users to select the most appropriate configuration regarding the end product manufacturing requirements. Further to the IMPRESS case studies, the performances of the platform will be validated through a satellite group. IMPRESS technological platform will accelerate the production and the time to market of micro nano-scale functional feature on multi-component devices in order to obtain an important reduction of needed supply chain space, technological risk and manufacturing costs of next generation plastic part products.",Flexible Compression Injection Moulding Platform for Multi-Scale Surface Structures,FP7,30 April 2013,01 May 2010,4616297.0 IMPRESS,Stichting Dienst Landbouwkundig Onderzoek * Foundation for Agricultural Research,photonics,"The objective of the IMPRESS project is to develop an affordable, portable, multiplexing and flexible Surface Plasmon Resonance (SPR) biosensor device (the IMPRESSOR), based on Plasmore's nanotechnology expertise, to obtain a fast impression of the quality and safety of food. Affordable: the system will be affordable for any small or medium enterprise or even private user, which is producing or distributing or consuming food in any country or region of the world. Portable: the system will be easy-to-use in any environment and must work outside any specialized laboratory. Multiplexed: the system will be able to measure the concentration of many contaminants in a single sample of food and within a single measurement. Flexible: the system is designed to develop assays according to the wishes of the future users (customized). Fast: measurements are done in minutes and the sample-to-result time will be around 30 minutes. This will allow the real time monitoring of the quality of food. This system will be constituted by two fundamental elements: 1) A disposable biochip customized for the detection of a set of parameters of the quality of the food (e.g. the detection of a set of allergens, toxins or antibiotics) and 2) an electronic reading system enabling the dispensing and the analytical screening of the food sample and the electronic evaluation, storage and communication of the results. Such a system will have a huge impact in the food monitoring protocols and will significantly contribute to the spreading of alternative, fast and reliable analytical methods for food safety control. This will help: - industries and distributors to provide safer and healthier food products, - public regulatory bodies to improve the quality of the food control tests while reducing the assay costs, - end-users and small distributors to verify the quality of their everyday food products",IMPRoved food safety monitoring through Enhanced imaging nanoplaSmonicS,FP7,30 September 2015,01 October 2011,589911.0 IMPROVED PRECISION,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,health,"The epithelial sodium channel (ENaC) is assumed to play a major role in the pathogenesis of chronic lung disease in cystic fibrosis patients. Its natural regulation by the cystic fibrosis transmembrane conductance regulator (CFTR) appears to be compromised based on the impaired function of CFTR. The missing downregulation of the channel results in increased absorbtion of sodium ions and fluid across airway epithelia leading to the depletion of the perciliary liquid layer and to the depression of mucus clearance.Several observations suggest that a downregulation of ENaC restores the perciliary liquid layer, thereby rehydrating the mucus and improving ciliary clearance in the lung. Therefore we propose to specifically downregulate ENaC expression by RNA interference. For this purpose we develop and apply new means of nucleic acid precision targeting both on the molecular and macroscopic level. The first level of precision is introduced by the use of ENaC-specific siRNA, a technology known for its high downregulating specificity. The second level of precision is brought about by uPA-receptor binding and nuclear localization peptide modules of novel nonviral molecular constructs for nucleic acid delivery. Protein transduction domain peptides will be used for the delivery of synthetic siRNA. A level of loco-regional precision is contributed by the administration of such constructs via the airways upon aerosolization. Yet another and novel level of precision and targeting is introduced by the association of viral and nonviral constructs for siRNA delivery and/or expression with magnetic nanoparticles, such that lung-specific accumulation and retention can be mediated by external magnetic fields. For this purpose novel magnetic vector formulations as well as magnetic field generating equipment are developed. These novel constructs and technologies will be evaluated in fetal and postnatal animal models in order to demonstrate their efficacy.",Improved precision of nucleic acid based therapy of cystic fibrosis,FP6,30 June 2008,01 January 2005,3504000.0 IMS,LABOR Srl,energy,"Aim of the IMS project is to develop an innovative technology and the industrial production process for a completely Building Integrated ThermoPhotovoltaic and Thermoelectric-climate conditionning solution. The system called Integrated Modular System (IMS) is conceived as a completely building integrated and self standing energy system; IMS works as bioclimatic regulator, realising a trivalent effect (Thermal-Photovoltaic-HVAC) in the same element, exploiting solar radiation as its primary energy source and making the building completely independent from the energetic point of view.The product is designed to be produced with relatively low cost and on flexible support, in order to be easily mounted with yard techniques and completely integrated in building during construction and restoration phrase. The aim of the project is to apply the most innovative and advanced nano-films production solutions achieved in Thermoelectrical and Photovoltaic field to obtain unique performances for the proposed system.On the external part of the building the PV effect is realised through deposition of low cost amorphous silicon to be integrated on the flexible polymeric pipes working as thermal captive elements. The TE subsystem is fed directly through DC current produced by the PV subsystem, and produces heat or cold by acting on the current polarity, such way allowing self standing and solid state air conditioning. The TE effect is realised bu exchange with a liquid vector, and than recovered for domestic hot water needs or dissipated. The element is integrated into the building structure (e.g. ceiling) to act the climate conditioning of the building, both heat and cold. The expected results are 1) the definition and design of the IMS product 2) The definition of the process for production of the IMS.",Integrated Modular System for energy self-sufficient buildings based on thin film Photovoltaic and Thermoelectric devices,FP6,31 December 2006,01 October 2004,1054951.1 INANOMOF,ICN2 - Institut Català de Nanociència i Nanotecnologia,health,"In InanoMOF, we aim to develop frontier Supramolecular and Nanochemistry methodologies for the synthesis of a novel class of structures via controlled assembly of nanoscale metal-organic frameworks (nanoMOFs) and inorganic nanoparticles (INPs). These methods will embody the premise that 'controlled object-by-object nano-assembly is a ground-breaking approach to explore for producing systems of higher complexity with advanced functions'. The resulting hybrid nanoMOF@INPs will marry the unique properties of INPs (magnetism of iron oxide NPs and optics of Au NPs) to the functional porosity of MOFs. The first part of InanoMOF encompasses the design, synthesis-assembly and characterisation of nanoMOF@INPs - advanced MOF-based sorbents that incorporate the functionality of the INPs used: magnetically controlled movement, in vivo detectability, enhanced biocompatibility and porosity, pollutant removal, or controlled sorption/delivery. The second part of InanoMOF entails studying the physicochemical properties of the synthesised nanoMOF@INPs and ascertaining their utility as drug-delivery/theranostic systems and as magnetic sorbents for pollutant removal. Specifically, we will study their stability in working media and determine their capacities for drug or pollutant sorption/delivery capacities. As proof-of-concept, we will study their toxicity in vitro and in vivo; enhancement of their in vitro therapeutic efficacy; and their capacity to remove pollutants (in real water and gasoline/diesel fuel samples) via magnetic assistance. In InanoMOF we will endeavour to establish the synthetic bases for controlling the spatial ordering of nanoMOF crystals, whether alone or combined with other nanomaterials (e.g. INPs, graphene, etc.). We are confident that our work will ultimately enable researchers to create MOF-based composites having cooperative and synergistic properties and functions for myriad applications (e.g. heterogeneous catalysis, sensing and separation).",Multifunctional micro- and nanostructures assembled from nanoscale metal-organic frameworks and inorganic nanoparticles,FP7,31 March 2019,01 April 2014,1942664.0 INCA-NANEP,University of Antwerp * Universiteit Antwerpen,health,"Neuroengineering is a growing area of Neurosciences, aimed at repairing, replacing and enhancing the function of damaged neuronal tissue. However, devices designed to interface the Central Nervous System (CNS) faces substantial clinical challenges, resulting from the CNS unique anatomy and physiology. Today, exciting perspectives are represented by reconstructive/repairing strategies, providing a functional bridge through the damaged tissue and restoring functions via implantable assisting devices. Lately, C-based nanomaterials, such as Carbon Nanotubes (CNTs) and Nanocrystalline Diamond (NCD) thin-films raised a lot of interest as the most promising materials in the building of nanoelectrodes and substrates for cell growth. Among their well-known properties (thermal, chemical, electrical), their in vivo stability and biocompatibility were explored and demonstrated. This project aims at studying the interactions occurring between these C-based nanomaterials and neurons, focusing on a significant step forward in the domain of neuroprosthetic materials, ultimately relevant to cognitive and regeneration/repair applications. The study of biological, electrophysiological and biophysical processes occurring at the interface between nanomaterials and neuronal systems is in fact intended to provide a solid foundation for generating novel biochips and cellular-level neuroprosthetic devices, ultimately designed to help repair damaged CNS tissues, and to build novel brain-machine interfaces. Such a research domain of Neurosciences, at the overlap between nanotechnology, physics and neurobiology, is not only offering today new exciting opportunities for better healthcare and nano-biotechnological applications, but it is also aimed to advance our basic understanding of the (dys)functional brains, through the use of C-based nanomaterials as novel tools for fundamental research, and ultimately leading to a new generation of nanomedicine and prosthetic applications in neurology.",INterfacing CArbon-based NAnomaterials to neurons: toward new horizons in cellular NEuroProsthetics,FP7,31 October 2015,01 November 2013,169800.0 INCEL,Ben-Gurion University of the Negev,health,"Cell adhesions play an important role in the organization, growth, maturation, and function of living cells. Interaction of cells with the extracellular matrix (ECM) plays an essential role in a variety of disease states , inflammation, and repair of damaged tissues. At the cellular level, many of the biological responses to external stimuli originate at adhesion loci, such as focal adhesions (FA), which link cells to the ECM . Cell adhesion is mediated by receptor proteins such as cadherins and integrins. The precise molecular composition, dynamics and signalling activity of these adhesion assemblies determine the specificity of adhesion-induced signals and their effects on the cell. However, characterization of the molecular architecture of FAs is highly challenging, and it thus remains unclear how these molecules function together, how they are recruited to the adhesion site, how they are turned over, and how they function in vivo. In this project, I aim to conduct an interdisciplinary study that will provide a quantum step forward in the understanding of the functional organization of FAs. We will analyze, for the first time, the three-dimensional structure of FAs in wild-type cells and in cells deficient in the specific proteins involved in the cell-adhesion machinery. We will study the effect of specific geometries on the functional architecture of focal adhesions in 3D. A combination of state-of-the-art technologies, such cryo-electron tomography of intact cells, gold cluster chemistry for in situ labeling, and modulation of the underlying matrix using micro- and nano-patterned adhesive surfaces, together with correlative light, atomic force and electron microscopy, will provide a hybrid approach for dissecting out the complex process of cell adhesion.In summary, this project addresses the properties of FAs across a wide range of complexities and dimensions, from macroscopic cellular phenomena to the physical nature of these molecular assemblies",Revealing the molecular architecture of integrin mediated cell adhesion,FP7,31 October 2015,01 November 2009,1294000.0 INDIGO,e2v Semiconductors SAS,information and communications technology,"Biochip technology allows to assess the expression of thousands of genes in parallel, opening the way to individualised healthcare. The INDIGO project will replace the current bulky and expensive technology used to hybridise and read fluorescent biochips by a lab-on-chip approach, with integrated signal processing and networking capacities. The project reconsiders the complete biochip user chain, and optimises each component in relation to others. At the core of INDIGO is an innovative, miniature and highly sensitive, yet disposable fluorescence-based biosensor. It replaces the usual glass slide supporting the biological reaction by a sandwich of chemical and optical layers monolithically grafted on a CMOS or CCD image sensor. Intermediate layers play an essential optical role for guiding and filtering light. The upper side of the sensor is devoted to biology, the lower side to imaging by direct, efficient light collection by the pixels. Improving signal level will enhance the sensitivity and robustness of the biological measurements. Such a lensless imaging device produces images with new characteristics and needs development of new data processing software. The image produced by the sensor will be read in a laptop-connected readout head, and then filtered, segmented and measured; the results will be normalised, written in a standard format, ready to be recorded into a database or transmitted through networks. With its user-friendly interface, the system will undergo clinical validation in biology labs, on samples from patients with different cancers and cardiovascular diseases. The INDIGO project is well suited to the joint IST and NMP call on bio-sensors for Diagnosis and Healthcare. On the NMP side, smart and hybrid materials like sol-gels with extreme characteristics, able to be industrially coated as thin layers will be developed. On the IST side, new data treatment chain will give standardised biological data usable by the medical community at large.",Integrated highly sensitive fluorescence-based biosensor for diagnosis applications,FP6,27 January 2009,27 July 2005,1600000.0 INDISPUTABLE KEY,Sveriges Provnings- och Forskningsinstitut AB,environment,"In several industrial processes a misuse of resources prevails that drastically could be reduced introducing smart ICT-tools allowing real-time traceability solutions. One rather spectacular application concerns the forestry-wood production chain where proper raw material for specific final products is an unsolved problem due to the complexity of biological raw-material in industrial processes. The magnitude of the problem, based on estimation of the total production of sawn wood in Europe 2002, is 25 million m3 equivalents to 5 billion euro. The Indisputable Key aims at developing methodology, technology, and knowledge to enable a significant increase in the utilisation of production resources in the forestry-wood production chain and to decrease the environmental impact. The developed systems will be based on the Individual Associated Data (IAD) concept, which facilitates automatic tracking of data along the forest-wood chain. Parameters involved, e.g. breast height diameter class, log number in the stem and cutting date strongly influences final wood product quality. Making information available at different stages along the forestry-wood chain requires automatic traceability systems, starting with logs in the forest. Communication between systems requires advanced information technology involving RFID-transponders and cellular phones adapted to industrial use by increased functionality. Frontline mechatronics, software, nano mechanics and electronics RandD partners will develop these systems. Verifying the function and environmental effects of the Indisputable Key systems will be implemented in different nodes of the forest-wood production chain by high-tech developers and evaluated by world-leading industry groups and fore-runner SMEs at hardwood and softwood forest industries in France, Norway, Finland and Sweden.",Intelligent distributed process utilisation and blazing environmental key,FP6,31 March 2010,30 September 2006,7717000.0 INDOT,Aixtron SE,energy,"The main objective of this project is to develop an MOCVD technology (Equipment, Precursors, Gas purification and Growth processes) for the industrial production of Indium Nitride (InN) quantum dot based devices. The know-how produced will also be applicable to the production of InN and In-rich InGaN alloy based devices. On a purely scientific basis, this project will address the epitaxy of a new, challenging and extremely promising semiconductor material, InN, and its nanostructures. This material has a huge potential for applications in infrared emission and detection, for telecommunication applications, high efficiency solar cells and electro-optic modulators. Another aspect of the proposed project is linked to environmental issues. Nitride semiconductor growth is a much more environmental friendly technology compared to the state of the art since it involves non-toxic precursors. The consortium consists of three industrial partners (AIXTRON, EPICHEM, SAES Getters) and one international level academic laboratory (GES). They will join their complementary expertise to develop the advanced MOCVD technology for InN based nanophotonic devices. The workplan has 9 technological and scientific workpackages and 1 related to management issues. The work will be realized through a strong interaction between all partners. GES will qualify the new precursors, MOCVD and purifier technology and will use those for the process design. Based on the process results the equipment and precursors will continuously be optimized. At the end of the project, an InN nanostructure based LED will be realized as demonstrator, to qualify the whole production technology developed in the frame of the project. The project addresses the key activity NMP-2004-IST-NMP-3 of the second joint IST NMP call FP6-2004-IST-NMP-2.",MOCVD technology for production of indium nitride based nanophotonic devices,FP6,31 October 2008,01 November 2005,1079915.0 INERA,BAS - Institute of Solid State Physics (ISSP),environment,"The Institute of Solid State Physics, part of the Bulgarian Academy of Sciences is the leading Bulgarian Research Institute in the field of solid matter research and its applications into multifunctional nanostructures.The INERA is an important mean for ISSP to rapidly increase its human and technological capacities, to reinforce its local networks and to deepen its partnerships on a European scale. It will mainly consist in an upgrade of equipment, scientific mobility trainings in leаding EU research centres, life-long trainings, partnership deepening and dissemination activities. INERA aims at preparing ISSP to become a national reference and reliable player on multifunctional planar nanostructures innovation niche employing available research capabilities and seeking EU soundness and visibility. The main expected project outcome for ISSP is to provide a new interdisciplinary view, to establish new links for common research and to encourage future synergies on national and international levels. The project will strengthen the capacity of business exploitation of research results and cooperation with industry and will build a long-term collaboration with research organizations and enterprises from EU. The project will have an important innovation impact as core research activities at ISSP are streamlined towards development of a Tunable Tool NanoMembrane: durable, high permeability, high thermal budget, tunable, scalable and Mass Production Capable Nanomembrane. This is expected to bring a new step in membrane technology development, triggering an avalanche of new products and processes in a wide range of applications including all known membrane industry aspects (separation by organic solvents, global water challenge like wastewater / desalination, fuel cells applications, and the life-health industries) with significant improvement of their energy effectiveness and environment ”shadow print”. INERA is supported by 8 leading EU research and 4 industry partners.",Research and Innovation Capacity Strengthening of ISSP-BAS in Multifunctional Nanostructures,FP7,03 July 2019,10 January 2013,4053611.0 INFEMEC,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),health,"Viruses and bacteria utilize proteins to attach and infect cells and tissues. Viruses have envoloped proteins that especifically recongnize receptors in the surface of the target cells. HIV-1 recognices receptor CD4 in the surface of T cell throghout its envolope glycoprotein gp120. In the case of bacteria, they attach to tissues using long filament called pilus. Bacterial pilus type 1 is composed of several protein subunit arranged in chain, FimA-FimG-FimG-FimH. The more external domain, FimH, is the adhesin binding domain that establishes the mechanical anchoring to tissues. Both, bacterial and viral proteins withstand mechanical forces than can go from few piconewtons to hundreds. However, very little is known about how force modify the structure and features of these proteins and ultimately how its affects infection. In this project we aim to investigate the effect of mechanical forces in the anchoring proteins and its role during attachment. We will concentrate in viral receptors CD4 and bacterial fimbriae proteins (Fim). We will use a novel atomic force spectometer that allows us to apply calibrated forces to a single protein molecule. This technique allows also monitoring chemical reaction under force such as the reduction of disulfide bonds or the binding of peptides and antibodies. These processes are known to be implicated in the infection of viruses and bacteria and they may have a mechanical origin. We will use bioinformatics and high-throughout screening techniques to identify molecules that alter the nanomecanichs of these anchoring proteins and that can potentially be used to prevent infections.",Nanomechanics of proteins involved in viral and bacterial infections,FP7,,,100000.0 INFERNOS,Aalto University * Aalto-yliopisto,information and communications technology,"Strong statistical fluctuations in meso- and nano-scale structures make their thermodynamic properties extremely dependent on the information available about them. The most basic process illustrating the importance of information to statistical systems is the information-to-energy conversion in the famous Maxwell’s Demon (MD). Our primary goal is to study both experimentally and theoretically the statistics of fluctuations and the role of information in thermodynamics of the nano-scale systems. The first milestone will be the experimental realization of the nanoscale MD. We will create an experimental set-up and develop the corresponding theory of the monitored statistical evolution with feedback that optimizes the information-to-energy conversion. Our vision is to develop the nanoelectronic and bio-molecular devices that will allow us to systematically explore the limits of information-powered systems, in particular to test the Szilárd’s limit relating one bit of information to extracted energy. We will also study statistics of energy fluctuations as revealed via equilibrium and non-equilibrium fluctuations of temperature. Part of these fluctuations has a quantum mechanical origin, but identification of this contribution in practice poses a challenging problem. Another novel extension of the MD work will be the study of thermodynamic constraints on quantum detectors. The principal novelty of our project is that it brings a rigorous experimental component to the field presently dominated by theory. Though the concept of a MD is tremendously important for development of modern statistical mechanics, MD-type experiments are still at their infancy. Our experimental study of MD will naturally lead to further progress in the relevant theoretical concepts.","Information, Fluctuations, and Energy Control in Small Systems",FP7,12 July 2017,01 January 2013,2294426.0 INFIBRENANOSTRUCTURE,Bilkent University * Bilkent Üniversitesi,energy,"The objective of this project is the realization of a radically new nanowire fabrication technique, and exploration of its potential for nanowire based science and technology. The proposed method involves fabrication of unusually long, ordered nanowire and nanotube arrays in macroscopic fibres by means of an iterative thermal co-drawing process. Starting with a macroscopic rod with an annular hole tightly fitted with another rod of another compatible material, by successive thermal drawing we obtain arrays of nanowires embedded in fibres. With the method, wide range of materials, e.g. semiconductors, polymers, metals, can be turned into ordered nanorods, nanowires, nanotubes in various cross-sectional geometries. Main challenges are the thermal drawing steps that require critical matching of the viscoelastic properties of the protective cover with the encapsulated materials, and the liquid instability problems and phase intermixing with higher temperatures and smaller feature sizes that require high thermal and mechanical precision. Initially, fabrication by drawing will begin with soft amorphous semiconductors, phase change materials, polymers of interest in high temperature polymers, followed by a wider range of materials, low melting temperature metals, metals and common semiconductors (Si, Ge) in silica glass matrices. In this way nanowires that are ordered, easily accessible and hermetically sealed in a dielectric encapsulation will be obtained in high volumes. Potentially, these nanowires are advantages over on-chip nanowires in building flexible out of plane geometries, light weight, wearable and disposable devices. Ultimately, attaining ordered arrays of 1-D nanostructures in an extended flexible fibre with high yields will facilitate sought-after but up-to-now difficult applications such as the large area nanowire electronics and photonics, nanowire based scalable phase-change memory, nanowire photovoltaics, and emerging cell-nanowire interfacing.",Fabrication and characterization of dielectric encapsulated millions of ordered kilometer-long nanostructures and their applications,FP7,30 September 2017,01 October 2012,1495400.0 INGENIOUS,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,health,"Polycyclic Aromatic Hydrocarbons (PAH's) and VOCs like benzene, toluene and xylenes (BTX) are compounds of great social and environmental significance, are widely used in industry, in many different applications. However, they and can present serious medical, environmental, and explosion dangers. Because they are toxic even at parts per- billion concentrations, it is essential to know their concentration in the air, especially in industrial and populated areas. Measurement of these toxic compounds at trace levels in multi analyte mixtures is still a challenging task however, and involves the use of expensive laboratory bound equipment. This severely limits risk analysis and timely initiation of preventive measures in a working environment. The main objective of the INGENIOUS project is the development, evaluation and validation of novel ultra-sensitive and selective nanostructured optochemical sensors for the detection of PAHs (polycyclic aromatic hydrocarbons) and BTX (benzene, toluene, xylene) from complex mixtures. Within the sensor concept, nanoparticle-based materials with high selectivity and sensitivity will be created by combining principles of molecular imprinting and plasmonic enhancement of molecular fluorescence. Silica and polymer core-shell nanoparticles with molecularly imprinted shells will be used as building blocks of self-assembling colloidal aggregates acting as chemosensing elements. The sensing elements and microarrays of sensing elements will be obtained using modern printing technologies such as ink-jet and microcontact printing. The combined sensor elements will be implemented on a polymer foil format and validated as sensor transducers. The technology will be incorporated into an in-plane optical read-out platform and demonstrated for specific end user applications. The suggested approach will be used to create sensor devices capable of detecting relevant analytes in industrial processes, occupational health and plants safety like PAH",Innovative Nanostructured Optochemical Sensors,FP7,30 September 2012,01 October 2009,1539000.0 INLIVETOX,Centre Suisse d'Electronique et de Microtechnique (CSEM) - Recherche et Developpement,health,"The InLiveTox project will form an interdisciplinary consortium at the European level, together with a key American research group to develop an improved in vitro model for the study of nanoparticle (NP) uptake, transport and cellular interaction, thus advancing our understanding of NP toxicity. Rather than repeat what has, or is being done in the field of aerosol NP and lung toxicology, InLiveTox will focus on the impact of NP exposure via ingestion, in the healthy and diseased gastrointestinal (GI) tract, vascular endothelium and liver. The key questions in this study are: (i) How do these tissues individually respond to NPs? (ii) How do the interactions between the different tissues modulate their responses? (iii) How does inflammation affect the toxicity of NPs and their ability cross the intestinal barrier? (iv) Which physico-chemical characteristics of NPs influence their uptake by intestinal epithelial cells and their subsequent interactions with endothelial and liver cells? The objective of InLiveTox will be to develop a novel modular microfluidics-based in vitro test system modelling the response of cells and tissues to the ingestion of NPs. Cell culture modules of target tissues such as the GI tract, the liver and the endothelium will be connected via a microfluidics system so that knock-on and cross talk effects between organs and tissues can be monitored. A major innovative aspect of the InLiveTox project pertains to the implementation of biological tissue models in a microfabricated compartmental cell culture system that allows multiple cell types to be addressed and investigated in combination. This system will be much easier, more convenient and ethically less questionable than animal testing, as well as more relevant than the in vitro single cell /co-culture models currently used. For this study, applications of the model will focus on NP toxicology, but the system could also be widely used in various applications of toxicology and pharmacology.","Intestinal, Liver and Endothelial Nanoparticle Toxicity Development and evaluation of a novel tool for high-throughput data generation.",FP7,31 July 2012,01 May 2009,2399989.0 INNATE,University of Bern * Universität Bern,information and communications technology,"The INNATE project focuses on noble metal nanocrystals in the quantum confinement size range as active elements in molecular electronic circuits. Supported by a successful proof-of-concept experiment, multistate switch and transistor function for these systems will be demonstrated, unparalleled in conventional electronics. This novel electronic function will be integrated with that of tailored redox molecules both in a vertical Scanning Probe Microscopy configuration and in a nanogap electrode set-up to form nanoelectronic circuits, thus bridging top-down and bottom-up approaches. Our strategy focuses on electrolyte gating at electrified solid/liquid interfaces, which can address physical gates down to 1 nm by achieving strong electronic coupling, and allows the target “device” to function under ambient conditions. In addition to its ambitious technical goals, the INNATE project will substantially contribute to prospects of professional maturity and independence of the applicant by adding crucial scientific competencies in the highly interdisciplinary area of nanoscale electrochemistry and molecular electronics, thus developing his research niche of organic–inorganic hybrid nanostructures towards a high-level molecular understanding of structure–functionality–reactivity relations. Research training objectives focus on advanced scanning probe and nanogap electrode techniques, together with complementary training in research management, high-level dissemination and networking activities, including links to industry. Fully integrated in the European Research Area, the project will significantly enhance visibility and attractiveness of European science and technology.",Integrated Nanocrystal Tunnelling for Molecular Electronics,FP7,03 July 2012,04 January 2008,246177.73 INNOBITE,Fundación Tecnalia Research & Innovation,construction,"INNOBITE project will transform urban and agricultural residues into high performing resource efficient products for the construction sector. The project finds support in two innovative ideas: (1) adding value to the inorganic fraction of wheat straw and (2) obtaining cellulose nanofibres out of highly recycled paper. Once isolated via environmentally friendly processes, these two renewable compounds will be used as high-performance additives for the development of a new series of bio-composites The incorporation of those natural components will improve current solutions in two construction applications: panels for indoor structures (interior walls, ceiling, flooring…) and profiles (decking, fencing…) by, respectively, increasing the resistance-to-weight ratio and improving the surface hardness and water absorbency. Other commercial bio-plastics as well as the two major fractions of what straw, cellulose and lignin, will be also incorporated into such materials (cellulose after chemical modification and lignin after being polymerised into both thermosetting and thermoplastic resins), and the resulting products will be finally tested for biodegradability. In the same way as wood, which is at the same time biodegradable and exceptional building material, the use of plant-derived products will increase the biodegradability of the biomaterials without compromising their structural quality. The project will destine more than 10% of the total budget to maximize the effectiveness of the exploitation activities, which will include thorough analysis of the cost effectiveness and environmental credentials of the products/processes developed and of new possible business lines and new business models. Also, the validation of developed technologies under the Environmental Technology Verification programme is expected to have a big impact on the exploitation.",Transforming urban and agricultural residues into high performance biomaterials for green construction,FP7,08 July 2017,09 January 2012,3199730.12 INNOSHADE,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,transport,"INNOSHADE is concerned with an innovative, nanocomposite-based switchable light transmittance technology developed previously for small sized objects (eyewear). It constitutes a breakthrough in smart shading technology by overcoming common limitations of state-of-the-art electrochromic devices. INNOSHADE enables the low cost production of electrochromic shading appliances with lower energy consumption and faster response. The overall objective of the proposed project is to scale up and study the underlying nanotechnology-based processes from laboratory to pilot line production, with the major goal to explore and extend the application potential by creating interest in several prospective user groups across sectors. In three interrelated sub-projects dedicated to I. Ophthalmic lenses, II. Domestic appliances, and III. Aircraft and vehicle applications, procedures shall be implemented to establish pilot production lines for the individual device components as well as for their assembly to run-capable devices up to a size of 45 x 80 cm2 (automotive sunroof dimensions). Cost reduction will be accomplished via high through-put manufacturing methods such as continuous roll-to-roll processing to achieve",Innovative Switchable Shading Appliances based on Nanomaterials and Hybrid Electrochromic Device Configurations,FP7,08 July 2014,09 January 2008,0.0 INNOVABONE,University of Vienna * Universität Wien,health,"The importance of developing novel approaches for bone repair is underscored by the heavy burden on health care costs and patient suffering caused by traumatic, osteoporotic and osteolytic metastatic bone lesions. To address these health challenges, we will develop optimally performing bioinspired biomaterials mimicking the natural physiological processes underlying bone repair. Our overall approach is to produce smart bioactive 3D scaffolds to fit within bone lesions, which we will then inject with functional, genetically-engineered self-solidifying elastin-like polymers with absolute-controlled molecular architecture and sequences containing specific domains for cell attachment, growth factors and calcium phosphate nanoparticles. The resulting bioactive, biodegradable scaffolds, biogels and regenerated bone will be analysed for biomaterial effects on bone growth, healing, foreign body reactions using cutting-edge in vitro assays, BioMEMS technology, in vivo animal models, non-invasive imaging and gene expression profiling for discovery of biomarkers associated with bone repair. Biomaterials will also be tested with biodynamic assays to assess strength, durability, toxicology, sterilisation reaction, eco-toxicology and risk assessment. Our multidisciplinary consortium with its extensive, state-of-the-art expertise consisting of private and public partners, cellular and molecular biologists, immunologists, physicists, bioengineers, and orthopaedic surgeons will tackle serious bone lesions with a comprehensive work plan to develop a prototype, evaluate it in vivo and in vitro, upscale its production and prepare the final material for clinical phase trials and commercialisation of the dual component product. Our ultimate aims are to ensure strong, healthy bone regeneration, reduce pain and suffering and to become a competitor in the biomaterials market of Europe.",Novel biomimetic strategy for bone regeneration,FP7,31 October 2015,01 November 2011,6199649.0 INNOVASOL,University of Eastern Piedmont * Università degli Studi del Piemonte Orientale,energy,"INNOVASOL aims to develop radically new nanostructured materials for photovoltaic (PV) excitonic solar cells (XSCs) really competitive with traditional energy sources. The main objective is to leapfrog current limitations of third-generation PV devices through a drastic improvement of the materials used for assembling XSCs. The first step is the substitution of the liquid electrolytes, currently used in dye-sensitised solar cells, with solid-state hole conductors. In parallel, semiconductor quantum dots (QDs) with tuned band gap, designed to enhance the photon capture efficiency, will replace the organic dyes as light absorbers. A striking improvement is expected from multi exciton generation (MEG) effects, overcoming the Shockley-Queisser efficiency limit of 31% for the PV conversion. In a second step, highly innovative QDs will be designed and synthesized: the QDs will be covered by self-assembled monolayers of amphiphilic dye molecules, mimicking the photosynthetic antenna system. The dye molecules will act as molecular relays (MRs), which connect the QDs to the transparent conductive oxide (TCO). Novel TCO architectures will be developed for efficient interface energy transfer and electron diffusion. Six academic institutions guarantee an interdisciplinary research, based on top level theoretical and experimental approaches. The high degree of knowledge of solid-state physics and chemistry, nanoscience and nanotechnology of the researchers assures that the new concepts and the objectives proposed will be successfully developed/pursued. Fiat research center and Solaronix, a SME leader in the XSCs production, will provide proof-of-concept prototypes to validate the innovative materials developed by the academic partners. Materials and technological solutions of INNOVASOL are original and will pave the way for future generation XSCs alternative to devices so far developed both inside and outside Europe.",Innovative Materials for Future Generation Excitonic Solar Cells,FP7,31 March 2012,01 April 2009,2899510.0 INNOVATIAL,German Aerospace Center * Deutsches Zentrum für Luft-und Raumfahrt,transport,"Due to its specific stiffness and strength, as compared to its low weight, Gamma-TiAl alloy is a promising material for automotive, energy and aerospace applications. However, its wider use is limited by its low sustainability to severe environmental attack in oxidising, sulphidising, hot corrosion as well as insufficient wear and erosion resistance at elevated temperature. Based on similar requirements in the machining industry, the INNOVATIAL consortium is tackling the demand for innovative coatings that can withstand attack up to 1000 C by complex environments, providing long term immunity against damage due to wear and erosion. This IP has the ambition to synthesise ultra-performance nanoscale-structured PVD coatings, which can provide environmental protection of Gamma-TiAl in order to boost the application of Gamma-TiAl to high service temperatures and long dwell times, and investigate application on hard metals thanks to: - Scientific understanding of thin films for Ti-Al materials. - Development of new coatings: interface engineering, nanocomposites, superlattice coatings, intermetallic coatings, top coats (Me-oxy-nitride glazes, thermal barrier coatings) - Upgrade High Power Impulse Magnetron Sputtering for thin film production - Use of new characterisation techniques for a complete microstructural characterisation at the sub-nanometre scale. Through horizontal and vertical integration, covering fundamental research, to demonstration and validation, the multidisciplinary consortium is integrating 10 renowned research centres, academics, 15 representative industrials (producers of Gamma-TiAl alloys, technology providers and end-users) among which 6 high-tech SMEs. Strong impacts are expected, both economic (European leadership of job-coating industry , of Gamma-TiAl components, sustain machining industry) and societal (lower fuel consumption and CO2 emissions in vehicles, improve lifetime of components, withdraw cooling fluids in industry.",Innovative processes and materials to synthesise knowledge-based ultra-performance nanostructured PVD thin films on gamma titanium aluminides,FP6,31 October 2009,01 May 2005,8589774.0 INNOVTEG,European Thermodynamics Limited,energy,"The aim of the INNOVTEG project is to create nano-structured thermo-electric materials based on (low cost and abundant) sulphur with carefully controlled structure and properties. By doing this our consortium will create a step-change in the application of thermo-electric technologies for large-scale solar renewable applications in the EU by developing thermo-electric at massively reduced cost (€5.20/kg). The technologies developed will be particularly suited to building integrated renewable systems. This will enable us to create a very low-cost thermo-electric system suitable for building integration that can achieve an output of ~30Wp/sq.m and a power generation cost of €533/kWp (significantly less than the corresponding cost of ~€3,000/kWp for PV systems) across a range of European climatic conditions. In so doing, the InnovTEG technology will offer greatly improved environmental performance due to improved reduced dependence on fossil fuels, reduced emissions (CO2, nitrogen oxides, hydrocarbons, carbon monoxide and particulates) at a cost that is affordable to the end-user. It is expected that the InnovTEG project will generate ~€200m million business growth for its SMEs within a 5 year period creating more than 171 jobs. The project results are expected to benefit other SMEs in the renewable energy, materials processing and electronics industry sectors. In addition, the technology has the capability to reduce CO2 emissions by 208,000 tonnes of CO2 per year 5-years post-project.",An innovative very low-cost thermo-electric technology for large-scale renewable solar energy applications.,FP7,31 August 2014,01 September 2012,1290979.0 INPHAS,Research Association Berlin * Forschungsverbund Berlin eV,photonics,"Fluctuation-induced interactions are typically forces arising from classical and quantum fluctuations. Paradigmatic examples are the Casimir effect and the van der Waals force. They are connected with a panoply of phenomena of great importance in different areas of physics. The exact knowledge of these interactions is rapidly becoming very important not only for fundamental purposes but also for the opportunities and challenges that they offer to nanotechnology and their impact on future devices. Recent theoretical and experimental investigations have shown that such interactions are tunable in strength and sign, opening new perspectives to investigate aspects of quantum field theory, atomic and condensed-matter physics, and leading to promising and amazing nanoscopic devices. This research targets an intensive theoretical and computational study of equilibrium and non-equilibrium fluctuation- induced interactions. It aims to acquire and enhance the competences in order to affront topics and problematics that are at the root of the future scientific development in all disciplines that deal with nanotechnologies. The methodology adopted will allow to put into evidence special and otherwise hidden features. The increased understanding will also facilitate the genesis of new ideas and the transportability of the results to other frameworks. This project is based on a multidisciplinary approach, combining concepts from different fields of physics, such as equilibrium and non-equilibrium physics, plasmonics, near field radiative heat transfer, diffusive electrodynamics, atomic physics and engineered materials. All these topics are intimately related within the framework of fluctuation-induced interactions, allowing for a complete perspective and physical understanding of these phenomena.","Fluctuation-Induced Interactions at the Interface between Photons, Atoms and Solids",FP7,28 February 2017,01 March 2014,75000.0 INPHOFLEX,Consejo Superior De Investigaciones Científicas (CSIC),energy,"It is the main goal of this project to bring to the host institution and the European Research Area the knowledge and technology to prepare current record flexible dye sensitized photovoltaic devices, previously developed by the candidate in South Korea and then the USA, in order to be able to further improve them, while endowing them with semi-transparency, using stretchable and bendable optical materials. The candidate has demonstrated that several key materials and processes provide better performance of bendable dye solar cells, i.e., enhanced efficiency and flexibility, by allowing the preparation of electrodes in which the electron diffusion length is longer and charge collection efficiency is consequently enhanced. However, highly efficient dye solar cells are opaque as a consequence of the particular diffuse scattering design employed to improve light absorption, which limits their application in building or automotive integrated photovoltaics. This proposal seeks to solve such drawback by introducing photonic nanostructures in different configurations, yielding both light harvesting enhancement and preserving transparency, hence placing Europe at the forefront of research in this specific area within the field of renewable energy. This final goal will be attempted through different approaches, each one challenging from the materials science perspective. Preparation of such highly efficient and transparent devices will combine the flexible solar cell processing tools previously developed by the candidate with the versatile optical material preparation techniques pioneered by the host institution. More specifically, integration of novel porous flexible photonic structures into the light harvesting layer, use of flexible mirrors attached to the back of the counter-electrode, and designed distribution of scatterers will be employed to reach the target.",INTEGRATION OF PHOTONIC NANOSTRUCTURES IN FLEXIBLE DYE SOLAR CELLS,FP7,31 August 2016,01 September 2014,173370.0 INPRO,NCC Construction Sweden AB,construction,"The InPro project will completely transform the Early Design phase of a building (new or renovation) project. At this influential phase, which represents only a fraction of the lifecycle of a building, decisions are made that determine over 70% of the total lifecycle costs. The transformation will be achieved through radical Early Design processes, supported by breakthrough innovations in business concepts and ICT solutions, that integrate four crucial aspects of Early Design: - Open and flexible collaboration between all stakeholders of the building value chain - Design from a lifecycle perspective - Decision support to make 'informed choices' based on knowledge of each decision's consequences on the building lifecycle - Early planning of build and operation processes based on computer enabled simulations of smart digital prototypes The consortium covers the whole construction value chain and is lead by five large and innovation-driven companies of the sector. InPro also includes a number of renowned European research organisations in construction, industrial processes and ICT, plus leading software companies and standardisation experts. It is also supported by the InPro Research Cluster with already 30 active members. With an estimated budget of 17 million euro over four years, InPro gathers a strong combined mass of industrial leadership and scientific excellence. InPro will have a significant impact on lifecycle costs, sustainability, inclusion of construction workers and low-tech SMEs in the Information Society, take-up of multifunctional and nano materials, and much more. The research work is accompanied by roadmaps and strategies for a widespread take-up of innovation. InPro will be a first powerful step in a paradigm shift in the European construction sector to using knowledge-based processes and open collaboration for an efficient, effective and sustainable built environment.",Open INformation environment for knowledge-based collaborative PROcesses throughout the lifecycle of a building,FP6,31 August 2010,01 September 2006,7499985.0 INSANE,Georgia Institute of Technology,information and communications technology,"Specially designed functional molecules are the next logical step in the ongoing miniaturization of mechanical, electronic, and opto-electronic devices. The present proposal responds to the necessity of systematic theoretical investigations of interfacial properties of electrode/molecule junctions. Attempting to bridge the ever widening gap between the highly specialized theoretical and experimental communities, it aims at the practical implementation of insights gained by theoretical, quantum-mechanical modeling by incorporating the real-world situation into the simulations and via intensive dialogue and close collaboration with experimental scientists.The main scientific objective of the proposed project is to outline a novel approach toward molecular electronic devices. Our intention is to induce strong electronic coupling of charge-transfer character between noble-metal contacts and covalently attached (self-assembled) molecules, thus integrating molecules and equally nanoscopic metal contacts into one functional unit. This goal is to be achieved by tuning both the molecules and the type, size, and dimensionality of the metal contacts in order to line up the metal Fermi energy with the frontier molecular orbitals and induce quantum-mechanical resonance between the two electronic subsystems. The proposed project links the research fields of theoretical and experimental surface science, nanotechnology, cluster physics, quantum-chemistry, theoretical solid-state physics, and the rich chemistry of functional p-conjugated molecules. The core part of this multidisciplinary, joint theoretical and experimental proposal will be the applicant’s computational work. He is to propose suitable systems, to establish a consistent framework of first-principles methods that allows to predict all relevant properties of these systems, and to reliably link theoretical considerations to experiments. Complimentary scientific training will consist of participating in these experiment",Investigation of Novel Self-Assembled Nano-Electronics - Towards Tunable Quantum-Mechanical Resonance,FP6,28 February 2009,01 March 2006,257381.86 INSIDE_PORES,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),energy,"Nanoporous materials play an important role in chemical industry. They are abundantly used as catalysts, catalyst supports and membranes and form the basis of new technologies, involving energy storage, novel reactions etc, mainly due to their unique structural or surface properties, which can be properly tailored to meet the process needs. The complete characterization of nanoporous materials still remains a difficult and controversial problem, mainly due to the difficulty in representing accurately the complex morphology of the pore matrix. To this end, the application of combined techniques aided by advanced model analysis is of major importance as it is the most powerful tool currently available. On the other hand, no matter how thorough and complete the characterization, it is pointless if not related to the process under consideration, since a very important parameter in any application is the materials' ability to retain their properties over a certain time period. The 'changes' induced on materials during their utilisation in specific applications, although often underestimated, are highly relevant and moreover crucial for the economic viability of the process. In this context, INSIDE_POReS NoE aims at the congregation of diverse expertise in the nanoporous materials field in order to develop methodologies for the 'in situ' application of both static and dynamic techniques and their combinations as a tool to probe the evolution of properties, which are relevant to specific processes that involve nanoporous solids. These processes span from materials synthesis (where particle size control, crystallization kinetics etc. play a significant role in the product) to their final application (where the evolution of phenomena occurring within the porous structure is critical). This is the starting point for the development of novel 'smart' alternative industrial processes that can take into account the evolution of properties of the nanoporous materials.'",IN Sltu study and DEvelopment of processes involving nanoPORous Solids,FP6,31 March 2009,01 October 2004,6800000.0 INSITUNANO,University of Cambridge,information and communications technology,"This proposal will use novel in-situ metrology to probe the atomic level mechanisms that govern the growth and device behaviour of nanomaterials in realistic process environments. We focus on the catalytic chemical vapour deposition of carbon nanotubes, graphene, Si/Ge nanowires and related heterostructures. The application potential for these nanostructures is large, but currently limited by insufficient control of growth. We propose to use a range of complementary in-situ probes, including environmental transmission electron microscopy, high-pressure X-ray photoelectron spectroscopy (XPS), in-situ X-ray diffraction (XRD) and in-situ Raman spectroscopy, to significantly advance the understanding of their growth mechanisms. We see these nanomaterials as model systems to advance the fundamental understanding of phase behaviour, nucleation and interface dynamics in nanoscale systems, which is the key to future materials design. Deeper insights into these phenomena are also crucial to understand the behaviour of nanomaterials under device operation conditions. We propose to address critical performance parameters of nano-structured Si-based anodes for Li ion batteries by in-situ nuclear magnetic resonance (NMR) spectroscopy and in-situ XRD methods under repeated Li cycling in an operational battery. We further propose to study the morphological origins of the collective adhesive and mechanical properties of carbon nanotube forests by in-situ scanning electron microscopy as basis for the design of biomimetic, functional dry adhesives and compliant interconnect structures.",In-situ metrology for the controlled growth and interfacing of nanomaterials,FP7,11 June 2018,12 January 2011,1367834.0 INSPECTRA,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,health,"The Principal Investigator and his team will open up new horizons in the field of laser spectroscopy through basic research on silicon-photonics-based Spectroscopic Systems-On-Chip (SpecSOC's). The key question being addressed is: how can the powerful concepts of high-index-contrast nanophotonics be combined with the extreme accuracy of silicon technology and with the performance of hybrid silicon/III-V integration in order to create system-on-chip functionalities for advanced (bio-)spectroscopy. We will first focus research on integrated lasers or Laser Systems-on-Chip (LaSOC's) capable of providing very wide wavelength tuning in the infrared, mid-infrared or visible. These lasers will have an unprecedented combination of properties. They will differ from existing semiconductor lasers in the sense that they combine the best of III-V semiconductor technology and silicon technology in unique cavity structures exploiting high index contrast in three dimensions. In the second phase of the project we will shift the focus from laser-oriented novelty to spectroscopy-oriented novelty and investigate SpecSOC's with an unprecedented system performance that matches the requirements of mainstream real-life spectroscopy. We will explore coherent optical detection techniques for sensitivity enhancement, microporous coatings for on-chip gas sensing and implant-oriented tissue spectroscopy. Our research will lead to a paradigm shift in laser spectroscopy, in the sense that it will turn an advanced spectroscopy system into a small form-factor commodity system. This will have an enormous impact on applications such as point-of-care medical diagnosis and medical implants, monitoring of air, water and food quality. Furthermore the on-chip spectroscopy systems will be highly valuable for fundamental research.",Silicon-photonics-based laser spectroscopy platform: towards a paradigm shift in environmental monitoring and health care,FP7,31 March 2016,01 April 2011,2183000.0 INSPIN,Norwegian University of Science and Technology * Norges Teknisk-Naturvitenskapelige Universitet (NTNU),information and communications technology,"InSpin will develop revolutionary nano-scale insulator spintronics that can replace or be integrated with conventional electronics and function at ambient temperatures. The innovation lies in the use of spin currents that in magnetic insulators are decoupled from charge currents and propagate with extremely low power dissipation. InSpin’s objectives are to provide a disruptive technology that is spin-based, low-power and ultra-low-noise, leading to superior oscillators, logics, and random access memory compared to those based on charge-based electronics. Ultimately, electrical current-driven magnon Bose-Einstein condensation and the associated super spin-currents enable dissipationless spintronics at room temperature. The strong reduction or even the complete absence of power dissipation in (super) insulator spintronics implies loss-less transfer of spin signals that circumvents the energy dissipation problem, which threatens to end Moore’s Law in information and communication technology. InSpin’s final deliverable is to fabricate the first functional spin wave bus with signal input and detection and to use this bus to realize a logic majority gate as the key component for future insulator spintronics.",Insulator Spintronics,FP7,02 April 2019,03 January 2014,2009301.0 INSTANT,Eberhard Karls University of Tübingen * Eberhard Karls Universität Tübingen,environment,"INSTANT will face the challenge of the detection, identification and quantification of engineered nanoparticles (ENPs) in complex matrices such as cosmetic products and engineered food and drinks. Therefore, new detection methods and technologies are mandatory. This is completely in line with the Call FP7-NMP.2011.1.3-1 which deals especially with innovative, practically implementable and cost effective measurement approaches for ENPs in complex matrices. Recently emerging ENPs include Ag, SiO2, TiO2, ZnO, and organic NPs. The “Opinion of the Scientific Committee on the Potential Risks Arising from Nanoscience and Nanotechnologies on Food and Feed Safety” released by the European Food Safety Authority (EFSA) (2009) also highlights the urgent need for such a tool. Accordingly, the interdisciplinary project INSTANT will develop an innovative and integrated technology for monitoring the exposure of consumers to ENPs using a label free opto-electrochemical sensor array in combination with novel recognition elements.",Innovative Sensor for the fast Analysis of Nanoparticles in Selected Target Products,FP7,08 July 2017,03 January 2012,0.0 INTASENSE,C-Tech Innovation Ltd.,energy,"Space heating accounts for more than 50% of the energy consumption of public & residential buildings, and reduction of this energy demand is a key strategy in the move to low energy/low carbon buildings. The careful management of air flow within a building forms part of this strategy through the control of inlet fresh air and exhaust air, maximising air re-circulation, and minimising the amount of fresh air which is often drawn in through a heat exchanger. However, there is a high risk that the air quality is reduced. Continued exposure to environments with poor air quality is a major public health concern in developed and developing countries. It is estimated that the pollutants responsible for poor air quality cause nearly 2.5 million premature deaths per year world-wide. Significantly, around 1.5 million of these deaths are due to polluted indoor air, and it is suggested that poor indoor air quality may pose a significant health risk to more than half of the world's population. Perhaps surprisingly, remedial action to improve air quality is often easy to implement. Relatively simple measures such as increased air flow through ventilation systems, or a greater proportion of fresh air to re-circulating air are sufficient to improve air quality. Low-energy air purification and detoxification technologies are available which will reduce the concentration of specific pollutants. Similarly, filtration systems (e.g. electrostatic filters) can be switched in to reduce the level of the particulate matter in the air (the principle pollutant responsible for poor health). The INTASENSE concept is to integrate a number of micro- and nano-sensing technologies onto a common detection platform with shared air-handling and pre-conditioning infrastructure to produce a low-cost miniaturised system that can comprehensively measure air quality, and identify the nature and form of pollutants. INTASENSE is a 3-year project which brings together 8 organisations from 5 countries.",Integrated air quality sensor for energy efficient environment control,FP7,30 September 2014,01 October 2011,2465354.0 INTEGRAMPLUS,QinetiQ Ltd.,information and communications technology,"The overall aim of this Service Action Integrated Project is to provide access services and prototyping platforms with a route to manufacture for highly integrated microsystems, combining smart silicon functionality with polymer in a multi-domain environment. This will be achieved by extending the Europractice manufacturing Cluster INTEGRAM, which focused on Silicon sensors and electronics, to multi-technologies (Silicon, polymers) and multi-domains (fluidic, optical, mechanical, electrical, biological). The consortium will also pull through and exploit for customers Design for Manufacturing principles being developed in the FP6 Network of Excellence PATENT-DfMM. This new multi-polar centre, INTEGRAMplus, will be a unique combination of competences across Europe linked with a network of supply chain partners and aims to provide European industry with a world-leading facility to stimulate take-up and accelerate time-to-market of smart mixed-technology components and solutions. The goal is to achieve a high degree of flexibility to address the need for increased complexity in microsystems without sacrificing the requirement for stable manufacturable processes. This will be achieved by focusing on standard processes and interfaces with design rules but offering additional functionality through incorporation of non-standard materials and linking multiple technologies. The focus will be on integrating Silicon-based MEMS components, which provide smart functionality, with polymer backplanes and platforms which provide additional functions, packaging and interfacing to the macro-world. The combination of the complementary capabilities of the partners and the ability to design, prototype and manufacture via a distributed network will demonstrate a new flexible manufacturing methodology for mixed-technology systems. INTEGRAMplus will aim to overcome these barriers and stimulate take-up of smart microsystems by SMEs in emerging markets for the information/ageing society.",Integrated MNT Platforms and Services - Service Action,FP6,31 December 2008,31 December 2005,3799459.0 INTELLIDRUG,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"IntelliDrug is aimed at developing an intelligent micro- and nano- system to provide an alternative approach for the treatment of addiction and chronic diseases. Chronic diseases and Drug addiction are among the most severe human problems, the latter being a major motive of crime and social instability. The continuous and endless efforts required from treating personnel and the afflicted persons further compromise the quality of life and give rise to severe compliance problems with therapy. In addition, limited effectiveness and adverse side effects are the result of the currently used medication administration methods. The proposed project IntelliDrug is aimed at obviating these problems. The proposed innovation will be reached by developing an intraoral micro-system, which contains a medication replacement reservoir and releases the medication in a controlled, intelligent manner according to the patient needs, in periods lasting days, weeks or months. The device will be reloaded in a simple non-invasive way. The micro-system comprises a medication release mechanism, a built-in intelligence, micro-sensors and micro-actuators, and a remote control. This project explores the application potential of micro-nano technology and investigates the integration technologies required to establish the nano to macro interface and to have 'nano' interact with the ambient. IntelliDrug deals with research and development of key technologies, such as biosensors and secure communication, low volume controlled drug handling, and the component integration into wearable systems, to manage health status. The resulting micro-system will help afflicted persons to put an end to their personal misery, to run a life as close as possible to normal and even to turn into a productive member of our society. It also will contribute to strengthen European research, cooperation and industry.",Intelligent intraoral medicine delivery micro-system to treat addiction and chronic diseases,FP6,31 December 2007,31 December 2003,2000000.0 INTELTEX,Nanocyl SA,health,"The overall objective of the INTELTEX project is to develop a radically new approach to obtain intelligent textile combining three innovative functions: measurement in a continuous way of mechanical stresses applied to the textile structure, thermal self regulated textile surfaces, and detection of toxic volatile solvents. This multi-sensitivity will be ensured by the integration of Conductive Polymer Composite (CPC) in textiles fibres. CPC, that is obtained by dispersion of conductive particles in a non conductive polymeric matrix, is a material whose electrical conductivity changes depending on external stresses such as temperature, strain and vapour atmosphere. By processing textiles structures integrating CPC-based fibers, it will be p possible to get multi-reactive textiles where the complete textile act as sensor. This new multifunctional textile will be used for many important applications with customised properties tailored to the following applications: Building application: wall fabric to detect cracks and temperature changes; industrial floors for leakage control and volatile solvent detection / Medical application: medical wear for monitoring body temperature / Protective clothing: combination of the three functionalities in fire-man clothing : monitoring near skin temperature, exterior temperature, mechanical stress (detection of an impact) and toxic volatile solvents such as carbon monoxide in fire.INTELTEX offer radical innovations in 2 areas: 1)Textiles area: development of a CPC-based technical functional textile combining 3 innovative functions mentionned above. 2) Materials and nanotechnology area: development of stable carbon nanotube based multiphase CPC by controlling at nanoscale level the dispersion of carbon nanotubes. The inter-particle gap is indeed a key-factor to get spinable CPC with the desired electrical properties.",Intelligent multi-reactive textiles integrating nano-filler based CPC-fibers,FP6,31 August 2010,01 September 2006,4699728.0 INTENSO,Jacobs University Bremen gGmbH,health,"The European Life science and chemical industries increasingly depend on effi-cient, sustainable, and cost-effective bioprocessing platforms to remain competi-tive. A critical assessment of current bottlenecks during (bio) manufacturing clearly indicates that the recovery and purification of biologicals in large scale in responsible for many inefficiencies. INTENSO proposes an evaluation of the current situation of the downstream processing scenario with the aim of identifying inefficiencies and concomitantly introduce a debottlenecking overarching strategy. The later will be build up on the basis of a multidisciplinary approach, which considers opportunities to im-prove the process technology and underlying chemistry / biology and materials science at the same time. INTENSO will work alongside 4 technological axes, targeting promising and up-coming technologies and tailoring such technologies to the manufacturing of various classes of (bio) products. Intensification of individual unit operations and global process integration, as well as, dovetailing with fermentation / cell cultivation will be employed to the mentioned end. INTENSO will target new classes of (bio) products like Monoclonal Antibodies (Mabs), pDNA (e.g. for genetic vaccination), Virus Like Particles (VLP) or nano-plexes. All the mentioned new products are part of most industrial R&D pipelines and offer an excellent opportunity to introduce innovative bioprocessing. The results of the project are expected to contribute to the understanding of current industrial downstream processing practice, to the definition and alleviation of current inefficiencies, to the development and / or implementation of novel technologies, and to more efficient / sustainable and cost effective (bio) manufacturing. Various technologies will be studied utilizing a nano-to-process strategy so as to introduce integration / intensification during bioprocessing.","Gaining Productivity, Cost Efficiency and Sustainability in the Downstreaming Processing of Bio Products by novel Integration and Intensification strategies",FP7,31 January 2017,01 August 2012,5260960.0 INTERACT,Technical University of Dortmund * Technischen Universität Dortmund,environment,"A major task addressed in the Strategic Energy Technology Plan of the EU is the sustainable power generation from fossil fuels. A crucial step here is the separation of CO2 from flue gas. INTERACT investigates the scientific and technological basis of radically innovative materials and processes. Strong improvement of the energy penalty of the capture process below 5 % points and reduction of the CO2 capture costs significantly below 50% by simultaneously substantially decreasing the footprint of power plants and thus the environmental impact. INTERACT follows the idea of the concurrent engineering in which new materials for CO2 capture i.e. membranes, highly efficient nanomaterials and biological absorbents are combined with innovative technologies resulting in real breakthroughs according to criteria given in Topic ENERGY 2013.5.1.2.",INnovaTive Enzymes and polyionic-liquids based membRAnes as CO2 Capture Technology,FP7,02 April 2019,09 January 2013,0.0 INTERACT-MEMNP,"University of Natural Resources and Life Sciences, Vienna * Universität für Bodenkultur Wien",health,"Cell membranes contain a large part of the delicate machinery of life and comprise the barriers controlling access to and from the interior of the cell. With the increasing use of nanoparticles (NPs) in medical imaging, drug delivery, cosmetics and materials the need is great and increasing to understand how NPs physically interact with cell membranes. On the one hand it is important to understand mechanisms to control risks of novel nanomaterials and to design therapeutic agents which can enter cells specifically and non-destructively. On the other hand, the structure and function of biological membranes inspire development of biomimetic smart materials for biotechnological applications which exploit or are modeled on biological membranes, but given enhanced functionality and external control of properties through incorporation of functional NPs. The aim of the proposed work is to develop understanding of the biophysical interaction of functional NPs with lipid membranes, in particular NP incorporation into and penetration through lipid membranes. Further, the aim is, based on that knowledge, to understand and control the self-assembly of superparamagnetic NPs into synthetic and cell lipid membranes to actuate them and control their physical properties in pursuit of novel biomimetic smart materials and cell analytical methods. The required level of control for this research has until recently been beyond the reach of existing NP systems (lack of synthetic control, stability and characterization) and methodology (lipid membrane models and high resolution techniques for their investigation). However, it can now be achieved using the Fe3O4 NP platform and surface-based and vesicular membrane model systems of tuned composition that I have developed. Using the same platform, breakthrough magneto-responsive biomimetic smart materials with application in drug delivery and cell manipulation with novel mechanisms of actuation will be self-assembled and investigated.",Interaction and actuation of lipid membranes with magnetic nanoparticles,FP7,31 December 2017,01 January 2013,1483486.0 INTERCER2,University of Trento * Università degli Studi di Trento,health,"Ceramic industry is broadly developed in Europe and the current investment is estimated at € 26 billion. With its € 9, 2 billion segment, Italy is a leader country in the production of traditional ceramics, while France, UK and Germany are driving countries for advanced ceramics, growing at 21% per year. Advanced ceramics are crucial for new technologies and nano-tech applications addressed to thermo-mechanical and bio-medical applications, while traditional ceramics have a worldwide market and have been suggested as materials minimizing the impact on the environment (when compared to other finishing materials). It may seem surprising that the strong industrial production of ceramic components is still based on empirically engineered processes, often poorly understood and difficult to control (Ewsuk, 1997). Consequently, there is a relatively large production of rejects and still broad margins for further process optimization. To this purpose, in-depth scientific understanding of the production processing is required, in order to reduce costs of ceramic component design and manufacturing and to produce ceramic components more reproducibly with improved performance and reliability. In particular, forming by powder compaction, binder burnout and sintering are the most sensible processes (Reed, 1995; Rahaman, 2006). The main aim of the research project is to develop novel advanced ceramic products in close collaboration between academic and industrial partners which will be directly oriented to industrial and social needs. The goal will be achieved by (i) improvement of the powder compaction and ceramic production process; (ii) development of novel advanced ceramic multifunctional materials and structures.",Modelling and optimal design of ceramic structures with defects and imperfect interfaces,FP7,30 September 2015,01 October 2011,2398292.0 INTERCOM,Universiteit Utrecht * Utrecht University,health,"Communication between immune cells is crucial for regulating the magnitude and quality of immune responses. A newly uncovered means of intercellular communication involves transfer of small cell-derived vesicles. I recently discovered that vesicles released by immune cells are enriched for small noncoding RNAs, which may act as regulatory RNAs that can influence gene expression in vesicle-targeted cells. Furthermore, remarkable parallels emerged between RNAs abundantly present in cell-derived vesicles and a group of host RNAs specifically incorporated into retroviruses. These shared RNAs may underlie the formation or function of both cell-derived vesicles and retroviruses. Until now, mechanisms behind selective incorporation of small RNAs into cell-derived vesicles and their function in vesicle-targeted cells are poorly understood. Aim of INTERCOM: To resolve how the exchange of small RNAs via cell-derived vesicles contributes to intercellular communication between immune cells. Key objectives: 1. To determine the diversity and plasticity of the RNA content of vesicle subpopulations released by immune cells. 2. To explain functional differences between immune cell vesicle populations based on their RNA contents. 3. To determine the function of structural RNAs shared by immune cell-derived vesicles and retroviruses. Tools in virology research will be used in combination with several high-end technologies, which were uniquely adapted in my lab for vesicle-related research. These include a high-resolution flow cytometric method suited to analyze individual nano-sized vesicles, RNA deep sequencing with previously developed data analysis methods, and super-resolution microscopic imaging. The proposed work advances our understanding of communication processes in the immune system. This knowledge can be applied in defining vesicle RNA-based biomarkers for immune-related diseases and in designing genetically engineered cell-derived vesicles for therapeutic application.",Communication between immune cells via release of RNA-carrying vesicles: Lessons from viruses,FP7,31 October 2018,01 November 2013,1499806.0 INTERCONY,Friedrich Schiller University of Jena * Friedrich-Schiller-Universität Jena,photonics,"Interface Controlled Nucleation and Crystallisation for Nanoparticle Synthesis (INTERCONY) is a materials science proposal bringing together theoretical studies, computer simulations and experimental studies on the formation of interfaces during nucleation and crystal growth in liquids. The consortium is a strongly interdisciplinary team consisting of groups, involved in materials science research (glass), physics (computer simulation, transmission electron microscopy), physical chemistry (theory of nucleation and crystallisation) as well as Europe´s leading supplier of special glasses, engaged in glass research, development and production. If a crystal is formed in a multicomponent liquid, it does not possess the same chemical composition as the liquid. Hence, in highly viscous liquids, the composition of the liquid will change near the emerging crystals. Such interface can form a diffusional barrier which leads to a decay in crystal growth velocity. Since in the latter case crystal growth is notably hampered, the formation of a high volume concentration of nano crystals with narrow size distribution is facilitated.INTERCONY will go beyond a purely thermodynamic and kinetic theory for nucleation and crystal growth by including a completely new approach taking into account the structure of the liquid. This is done by combining percolation theory with the theories of nucleation and crystal growth. Derived from fundamental studies, INTERCONY will furthermore provide technical guidelines for the preparation of nano glass-ceramics with emphasis on multifunctional materials especially for novel photonic applications. Results obtained within the proposed work program will drastically extent the knowledge on interfaces in multifunctional materials. This is of special importance for photonic materials, which are considered to be a critical driver for information technology.",Interface Controlled Nucleation and Crystallisation,FP6,30 November 2009,01 December 2006,1399978.0 INTERFACE,University of Copenhagen * Københavns Universitet,information and communications technology,"Quantum interfaces capable of transferring quantum states and generating entanglement between fields and matter are set to play a growing role in the development of science and technology. Development of such interfaces has been a crucial component in quantum information processing and communication. In the past decade quantum interfaces between atoms and optical photons have been extensively explored by a number of leading groups. Quantum state transfer between light and atoms, such as quantum memory and quantum teleportation, entanglement of massive objects, as well as measurements and sensing beyond standard quantum limits have been demonstrated by the group of the PI.",Quantum Optical Interfaces for Atoms and Nano-electro-mechanical Systems,FP7,06 June 2019,07 January 2012,0.0 INTERLINK,GEIE ERCIM,information and communications technology,"The goal of InterLink is to support coordination actions that will enable the European research community to interact with research communities outside Europe in a series of strategic, basic research areas, related to Information Society Technologies (IST). Thematic areas have been carefully selected based on the need to address the evolution of the Information Society in the next 10-15 years and include (1) software intensive systems and new computing paradigms, (2) ambient computing and communication environments and (3) intelligent and cognitive systems. These areas are closely related to a number of strategic research areas as well as to a number of ongoing proactive initiatives funded by FET in FP6. The main aims of InterLink are: 1. To identify and address world-scale, basic research problems where significant added value is expected to be gained from world-wide cooperation. 2. To establish communication and cooperation mechanisms within and beyond Europe in order to support the formation and functioning of related scientific communities. 3. To identify complementarities in the selected areas among EU countries and other involved countries that can give rise to knowledge and technology exchange. 4. To define joint research agendas, in terms of research priorities, road-mapping activities and joint RTD initiatives. The project is based on three Working Groups that will consist of international teams of researchers with proven expertise in their fields. Advanced communication tools will be provided aiming at a global networking of research communities. Several workshops will be organized to foster the RTD dialogue, promote the interactions within each Thematic Area and build technology roadmaps at an international scale. The ambitious goals of InterLink will be promoted through a number of selected channels and targeted dissemination and promotion activities.",International Cooperation Activities in Future and Emerging ICTs,FP6,31 May 2009,30 September 2006,900000.0 INTERNEW,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"In this project we propose the development and investigation of a new class of composite nanomaterials for specific energy-related applications. In fact, in most cutting edge applications related to energy harnessing, harvesting and storage, nanomaterials are playing mayor role in enhancing and optimizing device performances, while maintaining affordable production costs for their effective exploitation. Production of nanomaterials by design allows possibility of fine tuning the morphological and structural properties of complex structures, which result in new and/or modified functionalities at the nanoscale and at the macro scale, as a consequence. Critical role in determining such new properties is played by the interfaces among different nanomaterials, which regulate most of the physical and chemical characteristics of the new materials, like electronic band structure, optical properties, electron transport properties, etc. As a few examples, Lithium ion intercalation in Li-ion batteries, electron transport in excitonic solar cells, and charge injection phenomena in photoelectrochemical systems are mostly regulated by the status of the interface at the nanoscale of suitably prepared nanomaterials addressing specific tasks like, for instance, regulating physical and/or chemical sorption, intercalation, and electrochemical reactions, inhibiting charge recombination through charge screening during electron transport, fastening exciton dissociation and charge injection from visible light absorbers (being either organic dyes and metal-organic dyes or inorganic quantum dots). For this reason accurate and complete characterization of hetero-interfaces is a major issue for the development of advanced materials for energy applications. The Consortium is composed of highly qualified Research and Academic centers involved in the development and characterization of advanced nanomaterials.",Innovative interfaces for energy-related applications,FP7,31 December 2017,01 January 2014,474600.0 INTERNOM,Stichting Katholieke Universiteit * Catholic University Foundation,photonics,"Recent progress in electronics has largely been associated with controlled fabrication of low-dimensional nanostructures, so there is much interest in the transport, materials, photonic and plasmonic properties of small electronic nanodevices. Further technological breakthrough is expected by implementing novel materials such as magnetic semiconductors, carbon-based nanostructures and materials with strong spin-orbit coupling. Among a number of potential candidates for basic elements of future nanotechnology, graphene and topological insulators occupy a worthy place. Several established researchers with complementary experience unite in the project to tackle the key challenges in understanding intriguing interaction phenomena in new materials. Within this project we focus on transport and magnetortansport properties of graphene, graphene plasma-wave THz electronics, and interaction- and disorder-induced effects in topological insulators. We will uncover new physics originating in the inter-band transitions in these materials and demonstrate how to take advantage of new physical phenomena in making electronic and optical devices.",Interaction phenomena in novel materials,FP7,30 September 2017,01 October 2013,114000.0 INTERSOLAR,Imperial College London,energy,"There is rapidly growing interest in the science required to enable the conversion of solar energy into molecular fuels, motivated both by the need to develop a renewable, globally scalable transportation fuel strategy and the need to address the intermittency limitations of solar electrical power generation. Rapid progress is being made in the fabrication of inorganic, low cost, nanostructured photoelectrodes which utilise visible irradiation for such fuel syntheses, including water photolysis and CO2 photoreduction. However the efficiency of low cost photoelectrodes remains modest, due significantly to electron / hole recombination in the photoelectrode competing effectively with interfacial photochemistry. I propose to address this limitation by the use of multilayer interfaces designed to achieve enhanced uni-directional (i.e.: rectifying) charge separation, building directly from the extensive lessons I have learnt from my studies addressing an analogous challenge in dye sensitized solar cells. A key focus will be on the functionalisation of photoelectrodes with molecular and/or inorganic multi-electron catalysts to enhance the specificity and efficiency of the photoelectrode for fuel synthesis, exploiting recent, rapid advances in the syntheses of such catalysts. The use of rectifying interfaces is essential for the encorporation of such catalysts onto photoelectrodes, enabling the accumulation of multiple oxidations on the catalyst without this accumulation resulting in enhanced recombination losses. The proposal will undertake the assembly of such multilayer photoelectrodes, utlilising state of the art photoelectrode and catalyst materials, and the functional characterisation of these photoelectrodes, including measurement of interfacial electron transfer dynamics, with the aim of developing materials design rules which will enable systematic optimisation of photoelectrode function for efficient solar driven fuel synthesis.",Rectifying interfaces for solar driven fuel synthesis,FP7,31 March 2017,01 April 2012,1800000.0 INTERSTRUCFRICNANO,Bilkent University * Bilkent Üniversitesi,information and communications technology,"The physical phenomenon of friction is the main source of energy “loss” in a number of technical applications and industrial processes. Despite this fact, which holds significant economic importance, a complete understanding of fundamental physical principles governing frictional processes is still lacking. Considering that an ability to predict and control macroscopic friction depends on accurate investigations of friction at the nanometer scale, the research area of nanotribology –the science of friction, lubrication and wear at the nanoscale– has been established about 25 years ago. The main scientific tool that spearheaded developments in this field, the friction force microscope (FFM), provided researchers with a great deal of insight regarding frictional properties of nanoscale “single-asperity contacts” on different substrates as a function of various experimental parameters. Despite this success, many open questions remain regarding friction at the nanoscale, due to inherent limitations of the single-asperity FFM technique in terms of contact area, choice of materials, and poorly-characterized interface structures. Being motivated by recent developments in the field, we propose in this grant application to investigate the frictional properties of structurally well-defined, crystalline gold “nanoislands” on a number of substrates such as graphite and graphene using commercially available atomic force microscopes, as a function of island size, shape and crystallographic direction of motion. Additionally, we propose to use nanoislands made from bulk metallic glass (BMG) in amorphous and crystalline form, to test the influence of interface crystallinity on friction at the nanoscale. It is expected that the 4-year research plan described in this proposal will contribute significantly to the understanding of structure-friction relationships at the nanoscale, bringing the scientific community closer to a complete physical picture of the fundamentals of friction.",Investigating the Effect of Interface Structure on Friction at the Nanoscale,FP7,02 April 2019,03 January 2013,100000.0 INTIF,Weizmann Institute of Science,manufacturing,"Inorganic nanotubes (INT) and particularly inorganic fullerene-like materials (IF) from 2-D layered compounds, which were discovered in the PI laboratory 16 years ago, are now in commercial use as solid lubricants (www.apnano.com) with prospects for numerous applications, also as part of nanocomposites, optical coatings, etc. The present research proposal capitalizes on the leadership role of the PI and recent developments in his laboratory, much of them not yet published. New synthetic approaches will be developed, in particular using the WS2 nanotubes as a template for the growth of new nanotubes. This include, for example PbI2@WS2 or WS2@NbSe2 core-shell nanotubes, which could not be hitherto synthesized. Other physical synthetic approaches like ablation with solar-light, or pulsed laser ablation will be used as well. Nanooctahedra of MoS2 (NbS2), which are probably the smallest IF (hollow cage) structures, will be synthesized, isolated and studied. Extensive ab-initio calculations will be used to predict the structure and properties of the new INT and IF nanoparticles. Cs-corrected transmission electron microscopy will be used to characterize the nanoparticles. In particular, atomic resolution bright field electron tomography will be developed during this study and applied to the characterization of the INT and IF nanoparticles. The optical, electrical and mechanical properties of the newly sythesized INT and IF materials will be investigated in great detail. Devices based on individual nanotubes will be (nano)fabricated and studied for variety of applications, including mechanical and gas sensors, radiation detectors, etc. Low temperature measurements of the transport properties of individual INT and IF will be performed.",Inorganic nanotubes and fullerene-like materials: new synthetic strategies lead to new materials,FP7,02 April 2016,12 January 2008,1618238.0 INVENTS,University of Minho * Universidade do Minho,health,"The aim of InVents is to provide the advanced training of participants on the most recent achievements and future trends in the research domains dealing with biomaterials, regenerative medicine and drug delivery, contributing to form multidisciplinary 'hybrid' researchers prepared to face the future scientific and technological challenges. These domains are of crucial economical, health and social importance to Europe. Therefore, to conduct Europe towards a leading position in these areas that have been mostly dominated by USA and Japan, can only be accomplished by means of guiding research, creating new industrial spin-offs and transferring know-how to an all new generation of highly educated 'hybrid' researchers. In this context, the InVents will promote high quality science in a coherent series of 9 events, namely 2 conferences in the fields of nanoselfassembly materials for biomedical applications and biocompatibility and another 4 conferences focussing the fields of biomimetics, drug delivery, tissue engineering and stem cells; and 3 practical courses focussed on tissue engineering, biocompatibility, and drug delivery. The combination of complementary topics of each event will form a coherent multidisciplinary formation path aimed at improving the attendees' knowledge and skills required for conducting successful multidisciplinary research in disciplines such as tissue engineering or drug delivery. The InVents will provide a comprehensive training to an all range of scientists, at different levels of formation. There is presently no way of obtaining such high level quality and updated training in EU, even by means of trying to combine courses offered by different Institutions and/or different conferences and scientific training courses. The scientific contents of the proposed series of events was designed to be the best possible within the different fields. Moreover it comprises a strong level of integration and a very experienced and ambitious coordination.","An Integrated Series of Events for High-level Training on Biomaterials, Tissue Engineering, Controlled Drug Delivery and Related Emerging Fields",FP6,31 December 2009,01 January 2006,470417.0 INVISIBLE,Faculty of Sciences and Technology of the New University of Lisbon * Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa,health,"Imagine having a fully transparent and flexible, foldable, low cost, displays or at the glass window of your home/office, a transparent electronic circuit, do you believe on that? Maybe you are asking me if I am writing science fiction. No I am not. In fact this is a very ambitious objective but is tangible in the framework of this project due to the already acquired experience in the development of transparent thin film transistors using novel multifunctional and multicomponent oxides that can behave as active or passive semiconductor materials. This is an interdisciplinary research project aiming to develop a new class of transparent electronic components, based on multicomponent passive and active oxide semiconductors (n and p-types), to fabricate the novel generation of full transparent electronic devices and circuits, either using rigid or flexible substrates. The emphasis will be put on developing thin film transistors (n and p-TFTs) and integrated circuits for a broad range of applications (from inverters, C-MOS like devices, ring oscillators, CCDs backplanes for active matrices, biossensor arrays for DNA/RNA/proteins detection), boosting to its maximum their electronic performances for next generation of invisible circuits. By doing so, we are contributing for generating a free real state electronics that is able to add new electronic functionalities onto surfaces, which currently are not used in this manner and that silicon cannot contribute. The multicomponent metal oxide materials to be developed will exhibit (mainly) an amorphous or a nanocomposite structure and will be processed by PVD techniques like rf magnetron sputtering at room temperature, compatible with the use of low cost and flexible substrates (polymers, cellulose paper, among others). These will facilitate a migration away from tradition silicon like fab based batch processing to large area, roll to roll manufacturing technology which will offer significant advantages",Advanced Amorphous Multicomponent Oxides for Transparent Electronics,FP7,31 December 2014,01 January 2009,2250000.0 IOLICAP,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"The current requirements of the Post Combustion CO2 Capture (PCC) technology are: a) Reducing the parasitic energy load, b) Effectively addressing corrosion, c) Faster absorption/stripping rates, d) Less viscosity and less use of water, e) Confronting the problem of solvent degradation and volatility. These problems pose stimulating challenges for the synthesis of new solvents, aided by detailed molecular modeling of sorbate/sorbent interactions, and for new integrative module designs that enable their effective implementation in a process environment. In this context the IOLICAP proposal gathers expertise and skills form the domains of chemical synthesis of Ionic Liquids (ILs), molecular simulation/mechanical statistics, phase equilibrium, electrochemistry/corrosion, physicochemical/thermophysical characterisation, nanoporous materials & membrane technology and process engineering, aiming at the development and evaluation of novel Task Specific Ionic Liquid (TSILs) solvents that (a) short-term could replace the alkanolamines in currently existing PCC installations and (b) long-term would lead to the establishment of a novel CO2 capture process, based on hybrid absorption bed/membrane technology that will incorporate TSIL modified porous materials and membranes. Task Specific Ionic Liquids exhibit enhanced CO2 capture capacity, which is above the 0.5 mol/mol limit of the currently applied amine solvents. Due to the high number of possible IL structures that will be synthesised during the project and the easy tuneability of their chemical and physical properties it is expected that loading capacities above the threshold of 1 mol/mol will be achieved. In addition, ILs are less corrosive than amines and are dissociated so there is no need for using large quantities of water. ILs are also less volatile and less sensitive to flue gas impurities a fact that ensures less need for timely injection of fresh solvent. The aforementioned properties which will be studied and verified during the project, will have a high impact on the energy intensity of the capture process since they can lead to a significant reduction of the Scrubber/Stripper units size and consequently of the parasitic energy load. Ionic Liquid membranes are lately examined as candidates for CO2/N2 separation exhibiting performances that are above the boundary limit of a Roberson plot for this separation. IOLICAP project targets at the optimisation of the stability, selectivity (200), flux properties (1000-2000 Barrers) and production cost of Task Specific Ionic Liquid membranes and at the further enhancement of the process efficiency, through a combination of membrane technology with bed adsorption. Membrane technology is the less energy intensive candidate for CO2/N2 separation since there is no need for regeneration and constitutes a much more versatile and economically feasible technology especially for applications in energy intensive industry like the cement, steel and refineries.",Novel IΟnic LΙquid and supported ionic liquid solvents for reversible CAPture of CO2,FP7,30 November 2014,01 December 2011,3978128.0 IONACES,University Toulouse III Paul Sabatier * Université Toulouse III Paul Sabatier,energy,"Electrochemical Double-Layer Capacitors Electrochemical Capacitors (EDLC) are promising devices for clean energy storage applications. In EDLCs, the charges are stored electrostatically at the electrolyte / electrode interface, which confers them high power and cycling capabilities. Until recently, it was believed that charge storage in porous carbon EDLC electrodes could be achieved only if the pore size of the carbon was larger than the electrolyte ions with their solvation shells. Using Carbides Derived Carbons (CDCs) which have controlled pore sizes between 0.6 nm and 1.1 nm, we recently demonstrated that high capacitive performances could be obtained when the pore size is smaller than the solvated ion size. The origin of this capacitance increase is still unclear despite important modelling efforts achieved by many research groups. Using our fine-tuned, controlled pore size CDCs carbons with narrow pore size distribution, we propose here an integrated approach combining the use of experimental electrochemical methods (EQCM, EIS, CV…) and in-situ analytical techniques (NMR, XRD), to computational modelling (Molecular Dynamics, Monte Carlo and Reverse Monte Carlo methods) to elucidate the ion transport and adsorption mechanisms inside nanopores. A direct application of this fundamental approach concerns the energy storage with supercapacitors. Thanks to the unique features offered by the CDCs, we propose to develop the next generation of high-energy density micro-supercapacitors from bulk CDC films. The evidence of the increase of the capacitive ion adsorption associated with ion partial desolvation in micropores is also of great interest in different areas such as water desalination. CDCs, which have demonstrated volumetric capacitance improvement of 100% compared to activated carbon for supercapacitor application, are appealing materials for water desalination applications, which will be the last part of the project.",Understanding ion transport in nanoporous carbons; application to energy storage and sustainable development,FP7,31 March 2017,01 April 2012,1494050.0 IONBEATHETEROMAT,Imperial College London,energy,"The improvement, discovery or implementation of alternative energy sources represents one of the most dynamic and challenging trends in today´s research with connections to Materials Science, Applied Physics and Engineering, among others. In this context, current developments in high-efficiency energy conversion systems are based in the modification at the atomic level of heterostructured materials to improve the performance of devices such as solid oxide fuel (SOFC) and triple-junction solar cells (TJC). These two highly-engineered technologies demand specific analytical techniques with high spatial resolution to perform a chemical characterization capable of relating their structure and their functionality, particularly at the interfaces. In this project we will apply a novel instrumental configuration that combines surface science and surface analysis to probe materials surfaces and interfaces with unparalleled precision so that we will be able to better understand and optimise the materials we are developing. Two techniques, low energy ion scattering (LEIS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) are the best candidates to face such challenge due to their excellent surface sensitivity and depth resolution. The combined use of these ion beam techniques will provide an understanding of the surface and near surface processes in the latest generations of advanced materials. For this purpose, a deep understanding of the ion-solid interaction fundamentals is required in order to optimise the depth resolution and sensitivity of ToF-SIMS-LEIS to perform the most accurate and reliable analysis of the interfaces and nanometric domains in such heterostructured materials.",Ion beam techniques for the sub-nanometric characterisation of advanced energy conversion heterostructured materials,FP7,31 July 2013,01 August 2011,201049.0 IONE-FP7,University of Modena and Reggio Emilia * Università degli Studi di Modena e Reggio Emilia,health,"The vision of iONE-FP7 is to exploit for the first time flexible organic electronics for the development and testing of Active Multifunctional Implantable Devices (AMIDs) to treat Spinal Cord Injury (SCI). The devices will (a) have long-term stability associated to high biocompatibility and safety, (b) have reduced risk of a host versus graft immune response, (c) mimic the local microenvironment for stem/precursor cell recruitment and differentiation, (d) monitor locally the functionality of the regenerated nerve cells to intervene with loco-regional therapies (e) perform local stimulation with tunable electric fields, (f) deliver locally growth factors, neurotransmitters, and drugs. The use of flexible organic electronics devices (ultra-thin film organic field effect transistor (FET), organic electro-chemical transistor, nanoparticle organic memory FET) will advance the state-of-the-art of implantable devices for SCI from passive to active layouts that will promote nerve regeneration by a combination of local stimuli delivered on demand, will sense inflammation, and will control the immune-inflammatory response. The biomedical impact of the project will be demonstrated in vitro and in vivo. In vitro, the neural therapeutic plasticity induced by the iONE-FP7 device will be evaluated on stem cells, which will be differentiated to neural progenitor cells, and then to neural cells. In vivo, the study of neural plasticity will be transferred to endogeneous stem cells by implanting the iONE-FP7 device into a contusion SCI animal model. iONE-FP7 will acquire the knowledge and the technology required to regenerate the nerve in the niche of the injury.",Implantable Organic Nano-Electronics,FP7,28 February 2015,01 March 2012,3834336.0 IP4PLASMA,Spinverse Oy,health,"The IP4Plasma project aims to bridge the gap between IPR protected laboratory-scale innovations in the field of atmospheric pressure plasma assisted chemical vapour deposition (AP-PA-CVD) technology and its industrial implementation for advanced surface treatment and nano-scale coating of materials. This will be done by demonstrating the suitability of the technology for existing and new industrial applications in the medical products and diagnostics sector. A mobile pilot scale plasma treatment system will be designed and built for this purpose based on existing experience and IPR protected know-how, and subsequently validated in end user production facilities. In the project, the manufacturers of atmospheric pressure plasma equipment and the end users of the technology will work together with research organisations and experts in technology innovation to overcome the barriers to commercial application of a unique IPR portfolio.This will create new business opportunities with large market potential for the industrial partners involved (mainly SMEs), and thus strengthen their global competitiveness.",Industrial innovations based on EU intellectual property assets in the field of atmospheric plasma technology,FP7,31 December 2016,01 January 2014,3486875.0 IPACT,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"The aim of the iPaCT project is to address the unmet clinical need for an improved therapy of pancreatic cancer by developing a new integrated technology platform for image-guided thermal therapy. Yearly, 280000 new cases of pancreatic cancer are diagnosed worldwide. Being usually diagnosed late stage and without any efficient therapy available, basically all patients die with an average life expectancy of only a few months after diagnosis, leading to an overall low prevalence in society. Therefore, pancreatic cancer is a rare disease with an urgent clinical need for a new and improved therapeutic option. A potential breakthrough solution for the treatment of pancreatic cancer can be found in thermal therapies using high intensity focused ultrasound (HIFU) combined with local, temperature-triggered drug delivery. We propose a novel US-MR-HIFU system that integrates HIFU with two imaging modalities, i.e. Magnetic Resonance Imaging (MRI) and diagnostic Ultrasound (US) for image guidance of thermal ablation (T = 60â°C) and/or hyperthermia (T = 42-43â°C) of pancreatic tumours. For image-guided drug delivery, new temperature-sensitive nanocarriers will be developed that provide a high local dose of chemotherapeutic drug. Multimodal (molecular) imaging information, simultaneously acquired using the US-MR-HIFU platform, provides motion compensated temperature feedback as well as visualization of perfusion and drug uptake in the target tissue allowing personalized therapy. The consortium, including two innovative SMEs (Imasonic, Neagen), two hospitals (Klinikum der Universität München and University Medical Center Utrecht), Eindhoven University of Technology and Philips (a medical device company), represents the total chain from technology development, preclinical testing to clinical translation guaranteeing a clear route for later clinical use and a route to market for the SMEs partners, leveraging the competencies and strengths of a leading global healthcare company.",Image-guided pancreatic cancer therapy,FP7,31 December 2017,01 January 2014,5991070.0 IPHASEFLOW,German Aerospace Center * Deutsches Zentrum für Luft-und Raumfahrt,transport,"Aluminum-silicon base alloys are widely used in castings (foundry industry) due to their excellent castability and high strength-to-weight ratio. In the Al-Si alloys, the presence of small amounts of Fe and Mn brings about a complicated microstructure due to the formation of a rich variety of intermetallic phases (IMPs) during solidification, which generally have a negative effect on the mechanical and physical properties of a as cast part. The main goal of the project “iPhaseFlow” is to prepare new technology of intermetallic phases treatment by fluid flow in Al-Si casting alloys. The project investigates problems of artificial fluid flow influence on the growth, morphology and spatial arrangement of intermetallic phases in as-cast AlSi-base alloys containing especially Fe and Mn as alloying elements. The “iPhaseFlow” studies concerns detailed tasks: directional solidification of casting specimens in Artemis aerogel furnace by the presence of fluid flow and without it (in different solidification conditions), detailed analysis of the microstructure of the Al-Si alloys (dendritic pattern geometry, length and thickness of the IMPs, localization of the IMPs, their density and shape distribution), numerical modeling for physical understanding of the mechanisms leading to the anticipated changes in microstructure by the presence of IMPs and fluid flows. Project involves trainings in using advanced world wide unique facilities and modern scientific methods: directional solidification within Artemis, microstructure investigation by methods SEM/EBSD/EDX, x-Ray nano-tomography, x-Ray diffractrometry, metallography, quantitative image analysis (AnalySIS, Origin, IDL) and thermal analysis DTA, DSC. “iPhaseFlow” will be conducted in Institute of Materials Physics in Space MP of the German Aerospace Center DLR in Cologne.",The new technology of intermetallic phases treatment by fluid flow in Al-Si casting alloys.,FP7,09 February 2012,09 March 2010,230288.97 IPHOTO-BIO,University of Valencia * Universitat de València,photonics,"The proposed 'iPhoto-Bio' is an international research staff exchange programme - 'International collaboration on integrated photonics technologies for advanced bioapplications'. It aims to create a worldwide networking and knowledge transfer between six world-leading universities/institutes from five different countries: the United Kingdom, Spain, Brazil, China and the United States. The objective of the proposed programme is to establish long-term stable research cooperation between the partners with complimentary expertise and knowledge. The project objectives and challenges present a balanced mix between industrial application focused knowledge transfer and development and more far-looking studies for potentially ground-breaking applications by exploiting new emerging opportunities with integration of photonic components, micro-nano-bio systems, functional techniques, and innovative materials for advanced biosensing and biomedical applications.",International Collaboration on Integrated Photonics Technologies for Advanced Bioapplications,FP7,14 March 2018,15 March 2014,252000.0 IPLASMM,King's College London,photonics,"Photonic methamaterials have unique optical properties not available in natural materials. The key question is how to integrate metamaterials within nanophotonics circuitry to harness all the advantages they offer in controlling light on the nanoscale. iPLANET will develop a plasmonic nanorod metamaterial platform for applications covering the entire spectral range from mid-IR through telecom to visible and UV, be CMOS compatible and monolithically integratable in photonic circuitry. Using the unique optical properties of nanorod-based metamaterials, a very high density of photonic states can be achieved, essential for controlling light emission, scattering and nonlinearity in the nanophotonic environment. The project will challenge the frontiers of nanophotonics through the use of these specific to metamaterial properties to achieve integrated nonlinear photonic components with reduced size and energy consumption and integrated bio- and chemical sensors with increased sensitivity, multi-parameter sensing in a broad spectral range, all on the same metamaterial platform. This will be a transformative development for the applications of nanophotonics in optical information processing in integrated photonic circuits and for the realization of integrated sensors for point-of-care devices, security and environmental monitoring. The success of the project will unlock the potential of metamaterials for the improvement of the real-world photonic devices and provide insight into physical phenomena which are vital for various areas of optical physics and sensing. This will probably be the first demonstration of commercially-viable application of metamaterials. It will transform the areas of both nanophotonics and metamaterials and consolidate and enhance the European leadership in this field.",Frontiers in nanophotonics: integrated plasmonic metamaterials devices,FP7,31 March 2018,01 April 2013,2257458.0 IPMAGNA,Consejo Superior De Investigaciones Científicas (CSIC),manufacturing,"The proposed project concerns the study of magnetoplasmonic systems, that is nanostructures exhibiting both magneto-optic (MO) properties and surface plasmon resonances (SPRs). Particularly, localized SPRs appearing in magnetic nanostructures will be studied using local probe microscopy techniques. The typical magnetoplasmonic nanostructure is a Noble-Metal/Ferromagnetic-Metal/Noble-Metal trilayer. They can be fabricated either as continuous thin films that are subsequently patterned using lithography and etching, or by lithography, evaporation and lift-off. Nanostructure arrays will be fabricated in various compositions, shapes, separations and symmetries (in particular, colloidal lithography will be used to obtain disordered arrays, whereas e-beam lithography will be used to prepare ordered ones). First, their collective optical and MO behavior will be characterized using far-field measurements. Afterwards, the local electromagnetic near-field distribution at single objects will be imaged using Scanning Near-field Optical Microscopy (SNOM). The local measurements will be correlated to the optical and MO collective measurements. Both optical-fiber SNOM and apertureles SNOM (aSNOM) measurements will be performed. Metal-coated Atomic Force Microscopy (AFM) tips will be used for aSNOM. The interest is in performing aSNOM using ferromagnetic-metal-coated AFM tips, thus allowing for Magnetic Force Microscopy (MFM) measurements to be performed simultaneously with SNOM. The illuminated light will excite surface plasmons, and the magnetic component of their electromagnetic field distribution will be imaged using MFM. Magnetoplasmonics research has been pioneered at the host group, and the proposed project is a natural continuation of the so far host activity. Magnetoplasmonics allow for the development of active plasmonic devices (their properties can be tuned with a magnetic field), with applications in photonic nanocircuits and advanced biosensors.",Imaging the Plasmonic Activity of Magnetic Nanostructures,FP7,30 April 2013,01 May 2011,167065.0 IPSY,FEV Motorentechnik GmbH,transport,"Advanced Diesel combustion processes for passenger car Diesel engines such as Homogeneous Charge Compression Ignition (HCCI), or partial homogeneous combustion are developed for their potential to achieve near zero particulate and NOx emissions. One of the drawbacks of this technology is the difficult combustion control at medium and high load and consequently a limited operating range where NOx and particulate emissions are at a very low level. Therefore, future Diesel engines will combine HCCI at low load with partial homogeneity at part load and conventional Diesel combustion at high and full load. To cover these different loading areas a specific Diesel particle filter is necessary to reach PM and NOx emissions below the Euro V emission standards with a combination of regeneration strategies at low NO2 levels and low exhaust gas temperature due to efficient combustion processes. To achieve NOx engine out emissions below the Euro V level the engine has to be calibrated for low NOx emissions with the disadvantage of increasing soot at part and full load. Therefore the engines need traps. The accumulated soot in the trap can not reduced by continuous regeneration out of the missing NO2 in the exhaust leading to a higher active regeneration frequency at high trap temperature. To reduce high temperature soot oxidation trap material and catalytic coatings are necessary which allow trap regeneration below 650°C in an acceptable time. These targets will be achieved by a novel design of porous media and novel catalytic nanostructured materials in a compact unit, with tunable soot particle collection that will accommodate multifunctional catalytic coatings. With this content IPSY improves the environmentally behaviour and the market chances of future Diesel combustion processes. It meets the ideas of the general objective to strength the European Research Area of the priority 'Objective 1: New technologies and concepts for all surface transport modes'.",Innovative particle trap system for future diesel engines,FP6,31 December 2009,01 January 2007,988257.0 IQDOTPV,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),energy,"Great progress has been achieved over the last 20 years in the colloidal synthesis of semiconductor, metallic, and magnetic nanocrystals (NCs). The state-of-the-art synthetic approaches allow obtaining inorganic nanostructures with high degree of crystallinity and precisely engineered compositions, sizes, and morphologies, while solubility in nonpolar solvents provides remarkable processability of colloidal nanomaterials. In the present time, research efforts are largely focused on the implementation of colloidal nanocrystals in a broad spectrum of electronic and optoelectronic devices. Highly promising is the use of colloidal semiconductor nanocrystals (also known as colloidal quantum dots, QDs) in solar cells with the theoretical potential to overcome the Shockley–Queisser limit of 31-41% power efficiency for single bandgap solar cells. Recently, Sargent et.al. have shown that electronic properties of colloidal NC films currently limit performance of nanocrystal-based solar cells. Efficiency of the carriers' transport through NCs in the NC solid strongly depends on NC environment. However, NCs prepared by traditional colloidal techniques are capped with long-chain hydrocarbon ligands ('organic capping') introducing insulating layers around each NC. Significantly improved charge transport has been achieved by using shorter organic linking molecules or by partial removal of ligands by hydrazine treatment. Yet small and volatile organic molecules cause instabilities in solid state devices. Recently, an important breakthrough has been made through the use of small and chemically simple inorganic ligands such as discovery of metal-chalcogenide complexes and metal-free inorganic ligands. The goal of this project is to design inorganic surrounding for colloidal nanocrystals that will lead to semiconductor NC solids with predictable optoelectronic characteristics and eventually to novel absorber layers for all-inorganic, stable and efficient solar cells.",All-Inorganic Quantum Dot Films for Photovoltaic Applications,FP7,31 August 2015,01 September 2013,192622.0 IQUOEMS,University of Camerino * Università degli Studi di Camerino,photonics,"This project aims at the efficient realization of quantum interfaces for high-fidelity conversion and coherent manipulation of quantum states of phonons and of photons at vastly distinct wavelengths. We will consider different experimental platforms, e.g. photonic crystal cavities, nonlinear crystalline resonators, graphene-based nanoelectromechanical systems, and nanomembranes, with the aim of implementing interfaces that are able to interact simultaneously in a tunable way with optical and microwave fields. State transfer and controlled dynamics between radiation modes at completely different frequencies and between photons and phonons will be accomplished using diverse strategies, e.g. by tailoring the coupling of the interface with the fields, by exploiting electromagnetically-induced transparency, or the nonlinearities achievable in the strong coupling regime. The project results will enable new regimes for radio- and microwave electro-magnetic field detection, allowing quantum-limited amplification and readout of microwave and radio-frequency radiation. At the same time solid-state quantum devices which are now mainly manipulated by radiofrequencies and/or microwaves will become efficiently coupled to and controlled by optical fields.","Interfacing Quantum Optical, Electrical, and Mechanical Systems",FP7,30 September 2016,01 October 2013,2269320.0 IRENA,Aalto University * Aalto-yliopisto,information and communications technology,"This project aims to develop high performance materials, i.e. both metallic and semiconducting single-walled carbon nanotube (SWCNT) thin films to completely eliminate the use of the critical metals in electron devices: i) Indium in transparent conducting films (TCF, indium oxide doped by tin, ITO) and ii) Indium and Gallium as semiconductor In–Ga–Zn–O (a-IGZO) in thin film field effect transistors (TFTs). The target values for fully flexible transparent electrodes based on SWCNT thin films are 10 ohms/sq at 90% transparency, i.e. comparable to ITO-on-glass, with the midterm milestone of 40 ohms/sq at 90% transparency. The applicability of the developed SWCNT films will be further demonstrated in the high-performance TFTs on flexible and transparent polymer (Ion >1mA/mm, Ion/Ioff >10^5) and in 48 zone capacitive SWCNT touch sensor. Because of the rich resource of carbon element, recycling is not needed and the film material supports the friendly environment approach. During the growth of SWCNTs common transition metal nanoparticles will be used as catalyst. Based on the fundamental understandings, the performance and reliability of SWCNT transparent conductors and TFTs will be improved in this project, so that they can be used in highly performing products in the long term, such as AMOLEDs and future flexible electron devices with very large commercial potential in future consumer electronics. The project contributes to reduce the European and Japanese electronics industry dependence on the indium resources as well as the cost of manufacturing. Industrial partners from both Japan and EU will be invited to join the dissemination meetings to learn about the project results. Thus the project contributes to increase the competitiveness of the industry, especially to the SME's developing novel flexible electronics products. Project involves 3 world class teams from both Europe and Japan, having complementary expertise in nanotube synthesis, thin film manufacturing and flexible device manufacturing, in addition to detailed modeling of nanotube growth and thin film charge transport processes. Active exchange of researchers (minimum of 12 person months from EU to Japan and vice versa) will deepen the EU-Japan collaboration.",Indium replacement by single-walled carbon nanotube thin films,FP7,02 April 2019,09 January 2013,1799648.0 ISIS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"The project aims at investigating the injection mechanisms of spin-polarized electrons into silicon. The final goal is to demonstrate new capabilities of silicon as a spintronic material. Indeed, this will lead to new silicon-based devices with functionalities such as magnetic random access memories (MRAM), re-programmable logic devices, etc. In this study, a new hybrid structure will be used as a test device a spin injector as well as a spin detector. These are two electrodes each of them is constituted of a metallic ferromagnet as a spin source, a silicon substrate and a dielectric tunnel barrier in between. Unlike most works done on this subject, we propose to use silicon as the semiconductor channel, instead of compound semiconductors (e.g. gallium arsenide). The main advantage of silicon is its high spin diffusion length at room temperature which is in the order of a few microns. This allows studies with micron-sized devices that can be readily fabricated using the standard silicon technology.The project involves the microfabrication of test devices, their electrical characterizations, magneto-transport measurements and spin transport modelling. The project takes place in the framework of a more ambitious research program supported by a French national fund and involving three academic research institutes as well as two companies, one of them is a major semiconductor manufacturer. The aim of this program is to provide a silicon-based pre-industrial MRAM prototype. The work proposed in this project will contribute in providing the scientific basis to this wider research program. The combination of the excellent qualifications of the candidate in the field of magnetic materials, fabrication technology and magneto-transport mechanisms, with the widely-acknowledged experience of the host institute in spintronics, provide a unique potential to the success of such an ambitious project.",Injecting Spins Into Silicon,FP6,31 January 2008,01 February 2006,162754.0 ISLA,Gooch & Housego (Torquay) Ltd.,health,"2-micron fibre laser technology has the potential to open a whole new area of ICT & industrial applications. The well-known power scaling advantages, from increased core size & higher non-linear thresholds, offer a tenfold increase in 'raw power' compared with current 1-micron technology. Simultaneously, a host of applications specific to this almost unexplored region of the eye-safe spectrum become possible, including: industrial processing, free-space communications & medical procedures. Undoubtedly more will arise as currently exotic wavelengths become readily available. To date, the lack of suitable components has blocked R&D in this field. However, several recent disruptive component developments have changed the landscape: 1) Ho-doped silica fibre technology has advanced, providing a solid base for development; 2) All-fibre component technology offers integrated functionality; 3) Better isolator materials and new designs offer realistic potential for effective 2-micron devices; 4) New modulator materials & designs allow Q-switches, filters & switches; 5) Carbon nanotube composites offer effective sub-ps modelockers; 6) 790nm diode technology is ripe for development, for optimum direct pumping of Tm. ISLA will seize this opportunity to develop a set of 'building blocks' to define an integrated modular common platform for 2-micron Ho-doped fibre lasers consisting of compatible and self-consistent fibre, components and laser diodes. Not only will advances beyond the state-of-the-art in each of these component areas be achieved, but this will be attained through a coordinated program to deliver a genuinely integrated technology platform. Continuous wave, pulsed and short pulse lasers will be demonstrated through industrial applications (transparent plastic cutting and PV cell scribing). An industrial user group will identify new applications and aid exploitation routes, and the project results will be promoted within recognised standards bodies to benefit the whole of EU industry",Integrated disruptive componentS for 2um fibre LAsers,FP7,30 June 2015,01 October 2011,2839995.0 ISOGIRE,University of Bordeaux * Université de Bordeaux,environment,"The use of heavy stable isotopes for tracing the source of Metallic Trace Elements (MTE) in the environment has been well established during the last decade but focused mostly on simple cases (local point source pollutions), while Ag has remained unexploited in this respect. The ISOGIRE project aims at investigating heavy stable Cu, Zn and Ag isotope fractionation in the large scale (80000 km²) and well constrained Gironde continuum (as a model case system). The objective is to use MTE isotopes to identify and discriminate different (diffuse and point) source of pollutions and their evolution in time, accounting for biogeochemical processes (non-conservative behaviour by reactive estuarine mixing and biological uptake by oysters) that may modify their isotopic signatures. The ISOGIRE project relies on a multidisciplinary approach linking metallic trace elements isotope geochemistry, biology/ecotoxicology and mineralogical in situ analysis. The ISOGIRE project will address the recent issue of emerging Ag contamination observed in the Gironde estuary and surface waters worldwide, presumably due to the rise of Ag (and Ag nanoparticles (NP)) in consummer’s goods. A versatile analytical methodology for Ag isotopes measurements by MC-ICP-MS will be developed for various environmental matrices in order to evaluate the possibility of identifying and discriminating Ag and Ag-NP sources and follow their environmental route using their isotopic compositions. In addition of being complementary to the “nanosafetycluster” group, promoting studies on the environmental impact of NP at the European level, the ISOGIRE project is consistent with the priority objectives related to Environment from the work programme with respect to the multidisciplinary approach and development of new monitoring methodologies.","Insights from heavy stable isotopes to the study of Ag (and Ag-nanoparticles), Cu and Zn contaminations and biogeochemical processes in the Gironde Watershed and Estuary",FP7,02 April 2016,03 January 2012,201932.4 ISTRESS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"Intrinsic (or residual) stresses, resulting from manufacturing or processing steps, mostly define the performance and limit the lifetime of nanostructured materials, thin films, coatings and MEMS devices.",Pre-standardisation of incremental FIB micro-milling for intrinsic stress evaluation at the sub-micron scale,FP7,12 July 2018,01 January 2014,0.0 ITEM,University of Warsaw * Uniwersytet Warszawski,photonics,"The proposal combines efforts, which aim at the increase of scientific expertise and high-level of research within the field of semiconductor physics and technology for the next generation of quantum devices. More precisely the information processing will need in the future, semiconductor nanostructures based on new concepts such as quantum optics and spintronics which involve combination of new materials, optical properties and magnetic behaviour. This will require a combined expertise in the different fields of material science, epitaxial growth, structural characterizations, optical spectroscopy, and magnetic measurements. The host institution is a well-recognized university-based institution, with a well-documented skills in semiconductor physics. The expertise of scientists at the host covers such topics as: nanostructures, spintronics, magnetic semiconductors and blue optoelectronics. The knowledge is disseminated through existing curricula of graduate and post-graduate studies at the Warsaw University. Despite the existing experience in the area, a new momentum is necessary to maintain a high-level of research at the host institution and to face a strong international competition. This can be done by an extension of the host expertise towards new fields of the semiconductor physics and by combination of the existing competence with the new knowledge, which can be acquired during the lifetime of the project.",Semiconductor Materials for Information Technology,FP6,31 May 2010,01 June 2006,583595.23 ITQC,University of Cambridge,information and communications technology,"It is difficult to build quantum computers because it is hard to isolate and to control quantum objects with sufficient precision. I study new ways of quantum control which can be more robust and can implement elementary steps in quantum computers with greater precision. The techniques I use are based on topological phenomena. Topology is an area of mathematics that studies properties of objects that remain invariant under smooth deformations. In my case I study properties of quantum objects that remain invariant under small perturbation. This means, for example, that even if the shape, intensity or frequency of laser pulses, which control the evolution of trapped atoms, fluctuate we can still induce a desired modification of atomic states. Moreover, this can be done in complex systems involving many atoms. In particular I plan to investigate how topological quantum phenomena can be implemented in optical lattices.",Implementations of topological quantum computation,FP6,31 August 2007,01 September 2005,0.0 ITS LEIF,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"The Integrated Infrastructure Initiative ITS LEIF offers a platform for interdisciplinary research with high-quality low-energy ion beams. It is initiated by the Infrastructure Co-operation Network LEIF funded within FP5. ITS LEIF will combine the effort of 5 research infrastructures in 5 EU countries. 17 contractors and 14 user groups from 18 EU member states and associated countries will participate. It fosters mutual exchange of personnel and instrumentation to counteract fragmentation in this important multidisciplinary field. Research within ITS LEIF will mainly proceed at 5 infrastructures within a Transnational Access Activity, forming a Distributed European Facility. 4 Joint Research Activities (JRA1 - JRA4), which will improve and extend infrastructure performances by keeping their instrumentation at the cutting edge, will concentrate on the (i) development of sources and beams for complex ions, (ii) generation of low-energy, highly spatially and temporally resolved atomic ion beams, (iii) construction of electrostatic storage rings and traps, and (iv) production and characterisation of biomolecular targets. Such developed methods and instruments shall be jointly demonstrated in specific research fields (JRA5 and JRA6) where significant developments are expected: (i) low-energy ion induced radiation damage in biomolecular systems, (ii) antimicrobial ion coating of medical devices and ion-impact enhanced chemical reactivity, and (iii) low-energy ion induced nanostructuring of insulator surfaces and thin films. Cooperation will be strengthened by four network activities which interrelate the different projects, guarantee efficient internal and external communication, develop fruitful collaborations, disseminate the obtained knowledge, and develop joint strategies for further progress and applications. Of particular importance in ITS LEIF will be the support , the integration and training of young scientists.",Ion Technology and Spectroscopy at Low Energy Ion Beam Facilities,FP6,30 June 2010,01 January 2006,4794420.0 JBGIM,University of Bristol,manufacturing,"Coordination polymers are infinite arrays of bridging ligands bound to two or more transition metal ions. The potential application of coordination polymers in the areas of materials and nanoscience is significant as their properties can be tuned through variation of the transition metal ions and bridging ligands. To date, research in the area of functional nanoscale coordination polymers has been limited to amorphous (spherical) and crystalline (non-spherical) examples and the controlled growth of coordination polymers has not been realized. We propose the use of metal-containing diblock copolymer templates, which self-assemble in a number of different morphologies depending on the volume fraction of the blocks, to influence the structure of coordination polymers on the nanoscale, and for the first time demonstrate control over their size and shape. Our approaches will afford multifunctional materials with highly tunable properties, and the incorporation of diblock copolymers will allow for the rational design and controlled growth of nanoscale coordination polymers. This highly interdisciplinary and multidisciplinary research proposal requires a wide range of skills and this is exactly the mix possessed by the applicant (ligand design, coordination chemistry, stable-radical chemistry, electrochemistry, and molecule-based magnetism) and the host laboratory (polymer chemistry, materials chemistry, and nanoscience). The proposed research will bring a promising young researcher to Europe, and will lead to a new area of functional polymer and materials research where a range of potential applications are envisioned.",Functional Nanoscale Coordination Polymers: Controlled Growth by Metal-Containing Block Copolymer Templated Self-Assembly,FP7,07 November 2012,07 December 2010,173240.8 JELLY,Center for Cooperative Research in Biomaterials * Centro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE),health,"Certain proteins and glycans self-organize in vivo into soft and strongly hydrated, dynamic and gel-like supramolecular assemblies. Among such biomolecular hydrogels are the jelly-like matrix that is formed around the egg during ovulation, mucosal membranes, slimy coats produced by bacteria in biofilms, and the nuclear pore permeability barrier. Even though biomolecular hydrogels play crucial roles in many fundamental biological processes, there is still a very limited understanding about how they function. Our goal is to assess and to understand the relation between the organizational and dynamic features of such supramolecular assemblies, their physicochemical properties, and the resulting biological functions. We will investigate these relationships directly on the supramolecular level, a level that - for this type of assemblies - is hardly accessible with conventional approaches. To this end, we use purpose-designed in vitro model systems that are well-defined in the sense that their composition and supramolecular structure can be controlled and interrogated. These tailor-made models, together with a toolbox of surface-sensitive in situ analysis techniques, permit tightly controlled and quantitative experiments. Combined with polymer physics theory, the experimental data allow us to directly test existing hypotheses and to formulate new hypotheses that can be further tested in complementary molecular and cell-based assays. This project focuses on two types of biomolecular hydrogels: (i) the nuclear pore permeability barrier, a nanoscopic protein meshwork that regulates all macromolecular transport into and out of the nucleus of eukaryotic cells, and (ii) extracellular hydrogel-like matrices that are scaffolded by the polysaccharide hyaluronan and that are of prime importance in a wide range of physiological and pathological processes including inflammation, fertilization and osteoarthritis.",Biomolecular Hydrogels -from Supramolecular Organization and Dynamics to Biological Function,FP7,30 November 2017,01 December 2012,1497166.0 JOIN(ED)T,Universiteit Twente * Twente University,health,"Joint deficiencies and diseases are a common cause for disability, often with extreme pain, reduction of joint mobility and loss of function, affecting many EU citizens and resulting in tremendous costs. Very few existing surgically based protocols to treat osteochondral defects have yielded satisfactory clinical and functional results. JOIN(ed)T is composed of a consortium of 9 leading European institutes all with complementary expertise and resources on Tissue Engineering and Total Joint Repair. 3 interdisciplinary/-related research areas are defined: scaffold surface and architecture; biology and biotechnology of stem and progenitor cells; tissue development. The training project has a multidisciplinary approach, aiming to develop new knowledge on joint repair strategies and to contribute to the development of a treatment for degenerative bone and cartilage diseases, like osteo-arthritis. 9 early stage research fellows will be recruited and will be trained in the mentioned research areas thereby contributing to the development of a new generation of multidisciplinary researchers, fully able to work within the field of TE and prepared with necessary and state-of-the-art tools to become leaders in the field of regenerative medicine for joint repair. The proposed training includes: various joint activities mandatory for all fellows (e.g. introduction courses, master classes, TATE workshop, ESB conference); individual training modules; complementary training (e.g. Quality, Bioethics, Scientific English communication); visits to industrial network partners. All fellows are expected to obtain their PhD degrees after completion of the project. Innovative aspects of this project include the use of bioreactors to optimize cell culturing; the use and application of nano and microscale tools, to produce scaffolds, co-culturing systems, proteomics and genomics applied to adult stem cells to understand their differentiation mechanisms.",Joined Education for Tissue Engineering: a multidisciplinary approach to regenerate joints,FP6,31 January 2010,01 February 2006,1604988.13 KLING-CED,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The generation and characterization of attosecond laser pulses has been significantly advanced in recent years and two major tools are now at hand that can be used to explore ultrafast physics. The first is the ability to control electronic motion via waveform controlled laser fields. The second is the availability of single attosecond pulses that can be used to probe electronic motion in real-time. We want to use these tools to study collective electronic dynamics, which are of particular importance for the optical response of nanoparticles. These materials are of huge fundamental interest and have wide applications ranging from markers in medicine and biology over catalysts in chemistry to quantum computers. The motivation for studies on nanoparticles is related to the possibility of tailoring their dynamical behavior on the basis of size and shape. For the first time, we will explore electron dynamics in nanoparticles with sub-femtosecond time resolution. This way, we can gain information on the collective electronic properties of these materials on the timescale on which they occur in nature. Our work can have a huge impact on the development of nanoplasmonic devices. The proposed project will help the applicant to successfully reintegrate into academics and form the basis for his career as an independent scientist and group leader in attosecond science. The proposal will also contribute to keeping European research at the forefront in this quickly evolving scientific field.",Attosecond observation and control of collective electron dynamics in nanoparticles,FP6,31 December 2007,01 January 2007,40000.0 KNOWLEDGE NBIC,Zeppelin University * Zeppelin Universität,health,"The KNOWLEDGE NBIC project is a study into the knowledge and anticipated social consequences emerging from the NBIC fields, using a social scientific perspective. We propose to look into the patterns of NBIC knowledge production as well as the actual and potential use of and social resistance to such knowledge. In terms of knowledge production, our attention will focus on charting the institutional settings in which the NBIC fields are pursued and promoted. Relevant questions include: Who are the key actors involved? How do they figure in the overall ecology of both academic knowledge and socially relevant technologies? What funding mechanisms are used to promote convergence or synergy among different technological fields? Given the different origins of these fields, when and why did they start to 'converge' and to what extent? With respect to the use of and resistance to this knowledge, we will be concerned in particular with the growing moral, political and economic pressure to regulate, to police or even forbid novel knowledge as well as technical devices emerging from NBIC technologies. Such pressures have already become apparent in Europe and elsewhere with regard to biotechnology as well as stem-cell research and similar concerns are beginning to be voiced with reference to nanotechnology. The new convergence technologies can be expected to raise similar if not more accentuated concerns in that they promise an integration of biological reproductive processes, mental mechanisms of learning and information management at the nanoscale. Our proposed activities are exploratory at this stage as very little is as of yet known about the 'converging' component of 'converging technologies', especially from the social scientific perspective. For this reason, our project will combine exploratory studies with networking activities in order to build up a community interested in this emerging S&T field of study.",Knowledge Politics and New Converging Technologies; A Social Science Perspective.,FP6,31 March 2009,01 April 2006,800000.0 KRISTAL,TRW Automotive España SL,environment,"In addition to their traditional roles as seals and diaphragms, components made of rubber-like materials are increasingly replacing traditional metallic components (cams,slides) due to their ease of manufacture, lightness and cost. However, industrial stakeholders suffer from a lack of understanding of the time-dependent tribological behaviour of rubber-like materials (lubrication, wear & friction mechanisms). Moreover, surface modifications to improve tribological properties of rubber-like materials are rather unexplored, and the few existing coatings (graphite layers, PE layers or water based lacquers) suffer from a low wear resistance and bad adhesion. Therefore, understanding&modelling tribological behaviour of rubber-like materials is a mandatory step towards a knowledge-based engineering of their surfaces. Indeed, a radical innovation in the tribological behaviour of these materials can only be achieved through an integrated R&D approach for the development of advanced thin films. Hence, the overall objective of KRISTAL is to deliver innovative coating&surfacing techniques and associated modelling tools, to industrial partners for them to integrate tribology as a main design criteria of sealing&sliding systems using rubber-like materials. Because understanding tribological behaviour at nanoscale is a mandatory step to control tribological functions at macroscale, research will be carried out on three levels; going from nanoscale, then microscale to macro scale. This innovative approach will enable KRISTAL industrial consortium to: - develop quick and cost-effective design methods of sliding /sealing systems by considering tribological aspects - control friction during the life of the component by tailored surface engineering - minimize the environmental impact (noise, vibration, leakage, lubricant) of sliding /sealing systems by considering tribological aspects - obtain self-lubricating and long-life (maintennance free) sliding systems.",Knowledge - based Radical Innovation Surfacing for Tribology and Advanced Lubrication,FP6,30 September 2009,01 October 2005,8999956.0 L-SURF,Hagerbach Test Gallery Ltd.,environment,"Research on safety and security in enclosed underground spaces is of outstanding importance as current incidents (tunnel fires, terror attacks in metros etc) have shown. However currently the EU competence related to safety and security is largely unstructured, fragmented and mostly national oriented. Especially missing is a large scale research facility. The necessity for a European wide initiative in these respects also was identified and clearly expressed during the 1. International Symposium on safe and reliable tunnels, held in Prague in February 2004. Within the Design Study for L-SURF all relevant aspects for such a facility will be elaborated to a level that the facility could be established at least as a legal entity with the necessary structures and activities and that preliminary concepts and plans for the physical construction are laid out. The Study: describes the constructional lay-out of the facility, based - if applicable - on an entirely new concept for easily creating any contours, shapes and sizes of enclosed spaces needed, but also all other aspects like installations, environmental impacts etc. The concept will allow novel approaches to R&D work describes innovative measuring sensors, based on the latest technologies (e.g. nanotechnology) available evaluates the research needs and outlines the R&D - activities develops an integration process for the existing and projected national facilities with their competences and researchers, thus restructuring and improving the relevant EU competence while simultaneously showing ways for using R&D funds more economically shows ways and means to raise the necessary funds for the different stages in the setting up of the facility includes a business plan for a new legal entity dedicated to the establishing of L-SURF",Design Study for a Large Scale Underground Research Facility on Safety and Security,FP6,30 June 2008,01 March 2005,1678039.8 L-µPPT,JMP Ingenieros SL,information and communications technology,"The rapid emergence of new application domains and mission types has had a large impact on the evolution of spacecraft design. The current interest for micro-spacecrafts essentially proceeds from the wider availability of enabling technologies (micro/nano-fabrication), and from the desire to reduce development and launcher costs. Nanosatellites are also potentially useful as a mean to increase a mission's reliability by distributing a large payload over a fleet of small spacecrafts. However, the application range of micro-spacecraft is currently restricted by the lack of sufficiently compact, lightweight, high specific impulse micro-propulsion systems.",Innovative Liquid Micro Pulsed Plasma Thruster system for nanosatellites,FP7,10 July 2016,11 January 2011,0.0 LAB4MEMS,STMicroelectronics Srl,information and communications technology,General Goals,LAB FAB for smart sensors and actuators MEMS,FP7,06 January 2015,01 January 2013,0.0 LABCHIP-MULTIPLEXDNA,Autonomous University of Barcelona * Universitat Autònoma de Barcelona,health,"The detection of DNA hybridization is very important for the diagnosis and treatment of genetic diseases, for the detection of infectious agents and for reliable forensic analysis. Recent activity has focused on the development of hybridization assays that permit simultaneous determination of multiple DNA targets , using optical or electrochemical coding technology, based on unique encoding properties of semiconductor crystal nanoparticle tags (quantum dots). Described multi-target DNA assays were performed in batch mode, involving significant amount of steps, connected with the possibility of human error, time and reagents consuming. 'Lab-on-a-chip' technology offers tremendous potential for obtaining desired analytical information in a simpler, faster and cheaper way compared to traditional batch/laboratory-based technology. Particularly attractive for multiple DNA recognition applications (i.e. point-of-care) is the high-throughput, automation, versatility, portability, reagent/sample economy and high-performance of such micromachined devices.Overall objective of the proposed research is to create and characterize a portable microanalyzer, based on a novel advanced 'Lab-on-a-Chip' technology with magnetic separation and end-column quantum dots tracers voltammetric detection of multiple DNA targets for 'point-of-care' , automated, high-throughput, sensitive, selective and simultaneous assays. The new micro-total analytical system will rely on coupling of microfluidic transport of samples, effective flow-through magnetic separation complementary/non-complementary DNA targets and a novel chip-based voltammetric stripping detection of quantum dot tags. To successfully complete such advanced micro-total analytical system, several fundamental and practical issues will be addressed.",Simultaneous Detection of Multiple DNA Targets on Paramagnetic Beads Packed in Microfluidic Channels using Quantum Dots as Electrical Tracers,FP6,31 August 2006,01 March 2005,110058.0 LABOHR,University of Münster * Westfälische Wilhelms-Universität Münster,transport,"LABOHR aims to develop Ultra High-Energy battery systems for automotive applications making use of lithium or novel alloy anodes, innovative O2 cathode operating in the liquid phase and a novel system for harvesting O2 from air, which can be regenerated during their operative life without need of disassembling. LABOHR has 5 key objectives: (i) development of a green and safe electrolyte chemistry based on non-volatile, non-flammable ionic liquids (ILs); (ii) use of novel nanostructured high capacity anodes in combination with ionic liquid-based electrolytes; (iii) use of novel 3-D nanostructured O2 cathodes making use of IL-based O2 carriers/electrolytes with the goal to understand and improve the electrode and electrolyte properties and thus their interactions; (iv) development of an innovative device capable of harvesting dry O2 from air; and (v) construction of fully integrated rechargeable lithium-Air cells with optimized electrodes, electrolytes, O2-harvesting system and other ancillaries. Accordingly, LABOHR aims to overcome the energy limitation for the application of the present Li-ion technology in electric vehicles with the goal to: 1- perform frontier research and breakthrough work to position Europe as a leader in the developing field of high energy, environmentally benign and safe batteries and to maintain the leadership in the field of ILs; 2- develop appropriate electrolytes and nanostructured electrodes which combination allows to realize ultra-high energy batteries; 3- develop a battery system concept as well as prototypes of the key components (cell and O2-harvesting device) to verify the feasibility of automotive systems with: A) specific energy and power higher than 500 Wh/kg and 200 W/kg; B) coulombic efficiency higher than 99% during cycling; C) cycle life of 1,000 cycles with 40% maximum loss of capacity, cycling between 90% and 10% SOC; and D) evaluate their integration in electric cars and renewable energy systems.",Lithium-Air Batteries with split Oxygen Harvesting and Redox processes,FP7,03 July 2016,04 January 2011,2930728.0 LABSYNC,University of Leuven * Katholieke Universiteit Leuven,health,"The need for advanced light sources is well documented by the creation of new facilities such as SOLEIL, DIAMOND, MAX IV and the upgrades of older facilities. The applications of light sources encompass all aspects of sciences spanning the fields of physics, chemistry, biology, material science, electronics and medicine. An option to provide 'more light' to this community is to develop small laboratory sources beyond the standard and rotating anodes. Recently, several 'small scale synchrotron' sources were proposed, whereby the most advanced system is the Mirrorcle© developed by Prof. Yamada (Japan) with three functioning systems. In this project, we will design a complete small facility around the Mirrorcle© source. The Mirrorcle© is based on two RF klystron driven microtrons to accelerate the electrons first and second to obtain a electron storage ring with constant energy (6 MeV or 20 MeV) and high current (3A). The relativistic electrons produce intense far infrared radiation (FIR) and when targets are inserted in the electron path intense soft and hard X-rays can be produced from 90 eV up to the electron energy. The first goal of this project is to complete the characterization of the full radiation spectrum generated by the Mirrorcle© . This includes parameters such as the brilliance, the beam divergence, polarization and monochromacity. The second goal is to design a specific Mirrorcle© ring with four output ports, namely a FIR port, a soft X-rays port, a hard X-rays port and one port where the full spectrum is available. This includes designing the required targets as well as internal mirrors configurations. The third goal is to design specific beam-lines for these four ports that take into account the source. Finally, two specific user stations will be designed that make use of the unique abilities offered by such a small scale source, namely a multi-diagnostic in-situ, real-time nano-material synthesis system and a medical imaging and therapy station. In the first two years if the project the focus was indeed on using the Mirrorcle as the source for photons. In the third year of the project that has changes and the activities related to the Mirrorcle have stopped. They have been replaced by activities with liquid metal jet sources (for hard x-rays) and with laser plasma sources (for soft x-rays). However the general design goals have remained the same throughout the project.",Laboratory compact light sources,FP7,31 December 2011,01 January 2008,1599457.0 LAMAND,University College Cork,information and communications technology,"Scaling has driven the microelectronics industry for over 40 years and revolutionised information and communication technologies, health care, education, engineering, etc. Maintaining progress has becomes more challenging and costs of fabrication facilities are rising exponentially. Possible technical/cost solutions centre on development of ‘bottom-up’ techniques to (nano)pattern (the patterns yield device elements) surfaces rather than ‘top-down’ photolithographic (PL) methods that are the major cost of manufacturing circuitry (a single PL system is ~€65 million for next generation devices). Self-assembly is one route to nanopatterns but regularity/alignment over large areas is not consistent with circuit manufacture. Recent work on the self-assembly of block-copolymer (BCP) systems suggests that realisation of patterns of small feature size (~10 nm), at high density (i.e. spaced at ~10 nm), in precisely defined positions (to an accuracy of < 10 nm) on a large area substrate (12â€) is possible. This proposal will develop BCP methodology into a set of process techniques for subsequent industrial pre-development. The methodology centres around a combination of bottom-up and top-down techniques to provide the fidelity required to make the methods reproducible and reliable. This proposal would have significant value:- - Enable continued development of devices towards their ultimate performance. - Allow development of advanced circuitry at lower costs. - Prevent monopolisation of the semiconductor industry by 1 or 2 companies that can afford capital costs by opening the market to new competition. - Afford the EU with opportunities to develop profitable companies in materials, process equipment and emerging device technologies. Without a suitable EU-level engagement in this area, competition in the US and Asia will gain a significant technological lead that will minimise the EU’s potential to deliver new and advanced nano-electronic devices.",Large Area Molecularly Assembled Nanopatterns for Devices,FP7,06 June 2015,07 January 2010,3463000.0 LAMP,"National Agency for New Technologies, Energy and Sustainable Economic Development * Agenzia Nazionale per le Nuove tecnologie, l'Energia e lo Sviluppo economico sostenibile (ENEA)",information and communications technology,The project described in this proposal aims at developing a new methodology to obtain semiconductor quantum dots (QDs) regioselectively in a polymeric matrix by means of a heating probe (laser). This new method is designed to produce light emitting devices (LED/T) based on semiconductor/polymer nanocomposite emission without using lithographic processes.,LASER INDUCED SYNTHESIS OF POLYMERIC NANOCOMPOSITE MATERIALS AND DEVELOPMENT OF MICRO-PATTERNED HYBRID LIGHT EMITTING DIODES (LED) AND TRANSISTORS (LET),FP7,05 July 2015,06 January 2010,0.0 LANCER,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"The proposed project will realise compact, high-performance, CMOS-compatible and cost-effective planar optical amplifiers and lasers for next generation optical networks. The drive to combine the functionality of silicon electronics with optical data transmission to yield silicon opto-electronic integrated circuits operating at 1.5 ¿m is currently a technological priority of both the communication and the microelectronics communities. The present proposal intends to exploit the quantum properties of Si nanoclusters (Si-ncs) to efficiently excite erbium ions, which are the optically active species responsible for light amplification. In this way, the project will overcome the principal problems that have precluded the development of such amplifiers to date: poor emission efficiencies of erbium in silicon, small excitation cross-sections for erbium in silica, the requirement for expensive pump sources. The project will exploit two approaches: hybrid and monolithic integration. The hybrid approach will involve, for example, flip-chip bonding of an ion-exchanged glass waveguide with a planar Er/Si-nc codoped layer. Monolithic silicon amplifiers will be fabricated by co-doping silicon waveguides with Si-ncs and erbium ions. The devices will be electrically and/or optically pumped, the latter using a low-cost LED. Planar packaged devices with gains of 10dB less than 5cm in length are envisaged, allowing the deployment of inexpensive photonic components for metropolitan networks and fibre-to-the-home. The consortium includes universities, research centres active in electronics, signal processing and advanced optics, and a well-established SME in the field of optical subsystems.",Light Amplifiers with NanoClusters and ERbium,FP6,31 August 2009,31 August 2006,2199942.0 LANDAUER,University of Perugia * Università degli Studi di Perugia,information and communications technology,"The scientific objective of this project is to test the fundamental limits in energy dissipation during the operation of physical switches representing the basic elements of logic gates. We address the physical limits arising from a generic switch mechanism that is common to any digital device, with specific reference to the fundamental limit arising from the decrease of information in the computation procedure, also known as Landauer limit.",Operating ICT basic switches below the Landauer limit,FP7,08 July 2017,09 January 2012,0.0 LANIR,University of Limerick,health,"Every year, Alzheimer's disease (AD) affects about 800, 000 new patients in Europe and directly causes 50% of dependency of aged persons. Currently there is no test to diagnose this disease. There is a great need to improve outcomes for patients with lung cancer which causes between 15-28% of all cancer deaths in Europe. Chemical and structural imaging with nanoresolution under ambient conditions can significantly advance our understanding of biological processes at the sub-cellular level and provide understanding of early stage AD and lung cancer, improve the efficacy of therapeutic drugs and evaluate the real impact of nanomaterials to health and safety. In production processes the ability to image defects with nanometre resolution is critical for robust quality control of 'industrially important' products e.g. organic photovoltaic devices, antimicrobial textiles and functional coatings on biomedical implants. Nanoscale imaging available today does not permit in situ sub-cellular analysis and integrated metrology. This restricts our ability to optimise nanomaterials processes. Vibrational spectroscopy based imaging tools such as Infra-Red microscopy can provide a solution. Lateral resolutions of such techniques are currently limited to the micrometre range due to diffraction-limits. This project proposes a novel imaging tool Infra Red Nanoscope (IRN) that will break away from this diffraction limit. IRN will significantly improve the lateral resolution of IR microscopy on a table-top set up from the current state-of-the-art of 100 micron to 70 nm. It will also perform 3D imaging at a resolution of 500 nm, which is currently not possible in IR microscopy. A detailed methodology and instrumentation plan exists to implement a ready to commercialise table-top, nanoresolution, IRN. The instrument offers easy operation, flexibility and label free imaging of structure and chemistry that will stimulate new research in cancer treatments and early stage diagnostics of AD.",Label Free Nanoscopy Using Infra Red,FP7,30 September 2015,01 April 2012,4150000.0 LAPASO,Lund University * Lunds Universitet,health,"LAPASO will provide a unique training opportunity for 15 fellows in a highly interdisciplinary and intersectorial environment with the overarching scientific objective of advancing diagnostics in a wide range of critical medical conditions using advanced microfluidics and nanobiotechnology integration. Microfluidic particle fractionation based on the inherent properties of e.g. cells, microorganisms, organelles offers significant improvements over conventional techniques in terms of ease of handling and usage, speed and reductions in cost. We will consolidate the field at the European level and create a unique comprehensive training program that rests on solid experimental and theoretical foundations. Three leading experimental groups will provide the technological development of microfluidic label-free sorting based on dielectrophoresis, deterministic lateral displacement and acoustophoresis with strong support from leading theorists. The technology will be used to address key medical questions defined by our biomedical collaborators and partners in parasitology, bacteriology and oncology. Three companies are engaged to provide an industrial perspective on our work, specifically from a technological point of view with respect to treatment of infectious disease, advanced fluidics handling and DNA analysis and mass production of devices. To ensure an efficient transfer of knowledge across disciplines and across sectors the work will take place in close collaboration through frequent ESR/ER exchange between the partners. The training of a next generation of researchers will ensure the implementation and dissemination of these powerful novel key techniques to industry and end-users. Through the strong interdisciplinary and intersectorial character of the network, the ESR and ER will receive a uniquely comprehensive training above what a traditional postgraduate training would offer that in turn gives them a strong competitive advantage in both academia and industry.",Label Free Particle Sorting,FP7,30 September 2017,01 October 2013,4228418.0 LARGECELLS,University of Bayreuth * Universität Bayreuth,energy,"The task of developing large-area, thin film solar cells based on polymers as well as solid-state organic-inorganic (hybrid) systems will be undertaken. The required novel materials (charge transport polymers, semiconductor surfactants/compatibilizers and inorganic nanoparticles) will be synthesized and the compounds with the most potential will be scaled-up for the purpose of modern fabrication methods such as roll-to roll (R2R) processing. Additionally, the efficient devices will be tested and analyzed in out-door conditions in India and under accelerated ageing conditions in Israel to understand the degradation mechanism. Finally the basic information from stability studies will be used to design novel materials suitable for highly efficient devices of long-term stability. The programme is intensively intertwined with an Indian consortium, especially in the fields of novel materials, out-door testing, transfer and exchange of knowledge and methods.",Large-area Organic and Hybrid Solar Cells,FP7,31 August 2014,01 September 2010,1646528.0 LASER SPINNING GLASS,Rutgers University,health,"'A novel technique called laser spinning will be employed to synthesize glass ceramic fibres with several compositions and structures, showing diameters in the range from nanometres up to micrometers. This novel technique presents different advantages such as the simplicity of the experimental system which is carried out in ambient conditions and a high production rate, and also several potential possibilities such as the ability to produce fibres with different compositions and morphologies. All together set this novel technique in a promising position to be applied to synthesize bioactive ceramic fibres with tailored properties in the nanometre and millimetre ranges.The general objectives of the project are: to study the laser spinning process and the growth mechanism of the fibres, and to achieve the control of the composition and morphology of the fibres produced.'",Production of bioactive glass ceramics by laser spinning of nano- and micro-fibres,FP6,30 June 2007,01 January 2006,72775.68 LASER-CELL,AFC Energy PLC,health,"The alkaline fuel cell (AFC) is one of the most efficient devices for converting hydrogen into electricity. Project LASER CELL will develop a novel, mass producible AFC and stack design for stationary, industrial applications utilising the latest laser processing technology. This economically viable, sophisticated technology will enable design options, not previously possible, that will revolutionise the functionality and commercial viability of the AFC. Key parameters that will dictate fuel cell and stack design are; safety, reduced part count, easy of assembly, durability, optimised performance, recyclability and increased volumetric power density in a way which delivers a cost of under €1,000 per kW. To realise this vision, proprietary cell and stack features that have never before been incorporated into an AFC system will be employed and deliver a flawlessly functioning stack. In order to achieve these ambitious objectives, the consortium comprises world leading specialists in the fields of alkaline, polymer electrolyte and solid oxide fuel cells, advanced laser processing technologies, conductive nano composites, polymer production and large scale, stationary power plants. A cell design tool, based on physical and cost models, will be produced. This disseminated tool will provide design rational for material selection and geometric design and will be applicable for all low temperature fuel cells. Commercially viable porosity forming processes developed in this project will enable organisations working with other fuel cell types to re-evaluate the fabrication and design of their core technologies. Furthermore, other sectors that will benefit are; solar cell, aviation, medical and automotive. Having the ability to convert 'waste' hydrogen into electricity and being the 'pull through' technology for carbon capture and storage (CCS), AFCs could play a crucial role in helping the EU meet its reduced CO2 emission targets and improve its energy security.",INNOVATIVE CELL AND STACK DESIGN FOR STATIONARY INDUSTRIAL APPLICATIONS USING NOVEL LASER PROCESSING TECHNIQUES,FP7,30 November 2014,01 December 2011,1421757.0 LASER-PLASMON,Nottingham Trent University,health,"The ability of metal nanostructures to manipulate light at the nanoscale has resulted in an emerging research area called plasmonics. Plasmonics has developed into a rapidly maturing and broad research field, and it is progressively becoming an enabling technology for a number of forefront research areas like photovoltaics, chemical and biological sensing, medical therapy, information technology etc. However the fabrication of plasmonic devices is technically challenged because: there has not been developed yet a technique for precise control over the plasmon features, there is an engineering difficulty of delivering sharp nano-sized interfaces between metal and dielectrics, there is up to now no compatibility with large scale plasmonic applications and finally an experimental systematic study misses currently from the literature, which in turn provides a lack of feedback to technology for successful plasmonic large-scale applications. This proposal aims to address the hurdles mentioned above, through a wise implementation of a process technique that can be easily adopted by industry. This technique is Laser Annealing (LA), which can be a promising innovation in the field of plasmonics. The objectives of the present proposal are: 1. To develop and optimize seed materials for plasmonic nanostructures, 2. To identify the most appropriate LA system design and LA processing parameters, 3. To investigate the underlying mechanisms that govern the alteration of the NPs and their surrounding environment's structure and opto-electronic properties, 4. To deliver the currently missing link between materials, deposition techniques and LA process parameters, by means of an experimental library that would facilitate the future development of plasmonic applications.",LASER manipulation of PLASMONic nanostructures,FP7,30 April 2015,01 May 2013,221606.0 LASERMICROFAB,National Technical University of Athens,energy,"LaserMicroFab proposes a joint research programme exploiting on the knowledge and expertise of two academic partners (National Technical University of Athens (NTUA) and CNRS-LP3) and one SME, Oxford Lasers (OL) through inter-sectorial exchange of knowledge, networking activities and training in the areas of advanced laser processing for organic electronic devices and biosensors. The goal for this project is to develop Laser digital micro-fabrication processes such as selective laser micro and nano-patterning, laser micro-curing and laser micro-printing for precision patterning of complex materials, such as metallic nanoparticle (NP) inks and organic materials. The developed laser processes will be employed for the micro-curing of metallic nanoparticle (NP) interconnects to achieve submicron spatial resolution, for the nanostructuring of ultrathin (<50 nm) layers and for the printing of organic semiconductors for electronics and/or photovoltaics applications. Moreover, patterns of biomolecules will be printed using the laser micro-printing process with high spatial resolution (<10 μm) without compromising the viability of these delicate structures. The integration of laser micro-fabrication processes and the design of a laser platform based on the Oxford Lasers equipment (DPSS pulsed lasers ranging from nanosecond (ns) to femtosecond (fs) duration pulses) will be achieved, in collaboration with the research groups from NTUA and the CNRS-LP3. The success of this project will have a great impact on the market potential of Oxford Lasers' products and the research excellence of NTUA and CNRS-LP3 in the fields of materials engineering, biotechnology and chemical engineering, ensuring its multidisciplinary character. At the end of this project, a full set of parameters will be established and optimised as an innovative tool for material processing and will be further exploited for new applications and market areas.",Laser Digital Micro-Nano fabrication for Organic Electronics and Sensor applications,FP7,28 February 2017,01 March 2013,1125353.0 LASERPLASMA,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),manufacturing,"Laser Ablation-ICP-MS has become the most important and successful technique for direct elemental analysis in solids, including: silicate samples, nano tubes, glass, metals, archaeological samples, etc. Despite this, recent studies in LA-ICP-MS show that all three individual processes during sampling and detection (ablation, aerosol transport and vaporization, atomisation and ionisation) are distinct sources of elemental fractionation and can lead to inaccurate quantification. Therefore, any reduction in elemental fractionation will significantly improve the future applications of this technique.Research shall be carried out to describe the composition of the aerosol after ablation, during transport and within the ICP-MS. The main goal is to understand the various processes involved in LA-ICP-MS to achieve representative sampling, transport and excitation of laser-induced aerosols for quantitative analysis using non-matrix matched calibration standards. At present, a transport efficiency of 10 % of the laser-generated aerosol and the vaporization and ionisation efficiency of 2-3 % of the total introduced mass into the ICP represent a severe loss of valuable analytical information and leads to problems in quantification. Therefore, the aerosol formation and transport processes need modifications, which will be studied by direct gas phase reactions of theablated material using different gas combinations to enhance sample transport.Our research will also focus on fundamentals of 266 nm femtosecond laser ablation. Such a system will be established and used for aerosol production studying the capabilities of non-thermal ablation processes. The fs-laser ablation process leads to less thermal treatment of the ablated material, which is expected to create a more representative aerosol and a smaller average particle size distribution that is more efficiently vaporized and ionized within the ICP-MS.",Analytical applications of femtosecond laser ablation,FP6,31 December 2006,01 January 2006,174398.0 LASERPOM,"Ateknea Solutions Catalonia, SA",health,"Over the years, lasers have become common tools for various fields of industry and medicine, as well as forbasic and applied research. For many applications, it is necessary to precisely determine the output power of thelaser in order to achieve optimum results. However, no commercial powermeter exists, which allows laser powerto be monitored 'on-line' without the need for additional diffractive optical systems, designed for suchapplications. Moreover, traditional powermeters make use of thermoelectric or pyroelectric sensors, which areexpensive (especially when used to measure high power lasers), and suffer from long response times. Theproposed powermeter prototype is based on the scattering of light by nanoparticles, either deposited, orembedded, in a transparent substrate. Most of the incident laser light is transmitted by the nanoparticle-containing substrate, but a small fraction of the laser light is scattered by the nanoparticles. The intensity of thescattered light and its angle-dependent distribution can be measured to determine the power of the transmittedlaser radiation.The development of a low-cost system, which may be integrated in laser systems, will allow for a better controlof processes, resulting in improvements in process quality and safety. An initial technical feasibility check of theproposed technology has been carried out by the University of Barcelona, with such promising results that allpartners have envisaged a huge exploitation potential.",LOW-COST LASER POWERMETER WITH ULTRA-FAST RESPONSE FOR CONTINUOUS BEAM MONITORING,FP6,31 October 2006,01 November 2004,821858.0 LAYERENG-HYBMAT,Aalto University * Aalto-yliopisto,energy,"On-demand-designed and precision-synthesized multicomponent or hybrid materials with unorthodox combinations of properties are potential keys to fascinating next-generation devices. At the same time there is a strong scientific desire to create a comprehensive repertory of basic understanding, design strategies and experimental tools to construct such outstanding smart materials from different building blocks and to shape them into sophisticated hierarchical architectures. In LAYERENG-HYBMAT I propose a fundamentally new category of nanocomposite materials, that is, layer-by-layer grown coherent inorganic-organic hybrid materials where the cohesion between the layers is based on covalent bonding. Such materials are -once carefully designed and fabricated -able to display in a single material a tailored combination of properties of conventional inorganics and organics, and even beyond. The core hypothesis is that such intimately fused outstanding hybrids are materialized in a simple but extremely elegant manner by mimicking the state-of-the-art thin-film technology, i.e. ALD (atomic layer deposition), originally developed for purely inorganic thin films. The proposed method combines ALD and MLD (molecular layer deposition) cycles and enables the layer-by-layer deposition of coherent inorganic-organic thin films and coatings through sequential self-limiting gas-surface reactions with high precision for the composition and polymer-chain dispersity. With additional nanostructuring capacity these materials have the potential to open up new horizons in electronics, photonics, thermoelectrics, diagnostics, packaging, etc. The project builds on my long experience in frontier new-material research on other types of multilayered materials and successful proof-of-the-concept ALD/MLD experiments, and addresses all the fundamental aspects of new-material design, modelling, precision synthesis, property tailoring and function characterization.",Molecular-Layer-Engineered Inorganic-Organic Hybrid Materials,FP7,31 January 2019,01 February 2014,2358102.0 LAYSA,Fundación Tecnalia Research & Innovation,transport,"The use of composite materials in aeronautics industry has increased constantly over the last 35 years, due mainly to their high specific strength and stiffness combined with the possibility of designing complex geometry components that are more aerodynamically efficient than metals. But due to organic nature of polymeric matrix component, composite materials are electrically and thermally bad conductors and they tend to burn easily, emitting toxic gases and smoke. For that, they require affordable, effective and certifiable protection systems against atmospheric hazards such as icing, as well as fire and burning in case of accidents. Moreover, improved in field inspection techniques are required with the increased use of composite materials. Current technologies address those issues separately; ice protection is usually performed by mean of a metal mesh or foil incorporated into the outer ply of fabric on the skin of the structure, fire protection is performed with thermal barrier coatings on the structures and life monitoring is performed with embedded sensors. All of them add high weight penalty and complexity during the component manufacturing and posterior maintenance, even may go against the structural integrity of the component in some cases. LAYSA project aims for a new multifunctional layer to be integrated into composite structures, with ice and fire protection capacity. This can be achieved by integrating nanomaterials (NMs) such as Carbon Nanotubes (CNTs) or Carbon Nanofibres (CNFs) within a polymeric matrix, so that the whole nanocompoiste can be integrated in the composite structure like a layer. The direct benefits of the proposed application include: a) Improve aircraft safety and security, b) Structural weight reduction and simplification of manufacturing processes and maintenance operations due to elimination of current metals mesh or foils, by replacement with multifunctional layer integrated in composite structure.",MULTIFUNCTIONAL LAYERS FOR SAFER AIRCRAFT COMPOSITES STRUCTURES,FP7,12 July 2013,09 January 2008,3007603.0 LBL OF CNTS FOR SCS,Scientific and Technological Research Council of Turkey * Türkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK),energy,"The objective of this work is to prepare ITO free transparent conductive electrodes on glass and polyethylene terephthalate (PET) substrate via layer-by-layer deposition (LBL) of carbon nanotubes (CNTs) and to utilize the prepared electrode for solar cell devices. First, CNTs will be chemically functionalized with carboxylic acid and amine groups. Next, the substrates will be subjected to oxygen plasma etching to introduce hydroxyl groups, followed by immersing in gamma-APS (3-aminopropyltriethoxysilane) solution. Then, CNT multilayer will be formed on the gamma-APS modified substrate via LBL deposition of carboxylic acid and amine functionalized CNTs alternatively. The deposition conditions will be optimized by measuring the sheet resistance and optical transmission and it will be compared with standart ITO values. In addition, film thickness and morphology will be investigated with ellipsometry and AFM, respectively. Moreover, the CNT multilayer film on the substrate (glass and PET) will be subjected to adhesion and chemical resistance test, and to mechanical bending tests for PET substrate. Finally, solar cell device will be fabricated on the CNT multilayer electrode by using commercial photoactive polymers. The electrical properties and device efficiency values will be investigated and compered with the one with ITO coated substrate. Here, I believe that this proposal is very relevant to the work programme since it includes material science, nanoscience, and optoelectronic and energy device application, which are known to be among the core topics of FP7 programme. Also, the CIG programme is very relevant to myself since i started my career in Turkey (associate country of FP7 programme) as a fresh PhD holder after i came back from South Korea, where i resided and completed PhD work.",Preparation of ITO free transparent conductive electrode via layer-by-layer deposition of carbon nanotubes and its application for solar cells,FP7,31 March 2015,01 April 2012,75000.0 LC-ENERGY,Stichting Katholieke Universiteit * Catholic University Foundation,energy,"This proposal aims to improve the current generation of organic photovoltaic materials by controlling the molecular morphology, a key parameter in the development of organic solar cells. Self-organisation is activated by a newly discovered nanophase segregation process between rod- and disc-shaped molecules. Moreover, the overall liquid crystalline properties of the system allow macroscopic alignment, giving rise to an optimised geometry at all length scales. The proposed project covers the entire chain of knowledge: the design and preparation of the nanophase segregating materials, a detailed investigation of the electro-optical properties, and the analysis of the photovoltaic behaviour. This approach is an attractive method for studying functional materials and allows a direct link from fundamental research to technology-based industries. Apart from developing new concepts in light harvesting and sustainable energies, the proposal envisages advances in the field of nanosciences, particularly in the control of self-organisation and nanostructure formation. Basic understanding of the parameters for self-organisation will be generated, which contributes to the process of conceptualisation, required to support future technological breakthroughs in the field of nanosciences. In the proposal, a close collaboration between the scientist from top-level institutes like MIT, Boston and the University of Nijmegen is realised. The institutes provide a state-of-the-art training opportunity for the applicant. Knowledge and experience built-up during the project can easily disseminate into national and European projects concerning photovoltaic technologies.",Photovoltaic Materials from Novel Self-Assembling Nanostructured Liquid Crystals,FP6,,,272502.0 LCAOS,Technion Israel Institute of Technology,health,"The LCAOS project will develop and test a new diagnostic tool, able to detect: (i) the presence of lung cancer (LC), and (ii) an increased risk of a patient developing LC in the future. Diagnostic tests currently available are unsuitable for widespread screening because they are costly, occasionally miss tumours, are not time-efficient, nor free of complications. LCAOS will overcome these problems by using an approach based on volatile biomarkers emitted from cell membranes. A multidisciplinary effort, incorporating nanotechnology, biomedical engineering, medical oncology, and computation strategies, will develop a highly-sensitive, inexpensive, and fast-response, non-invasive, artificial nose (known as, NaNose), building on the coordinator's earlier success in this area. The NaNose will be able to detect pre-neoplastic volatile biomarkers that indicate an increased genetic risk of LC, and the presence of LC. It has already been established that these biomarkers can be detected either directly from the headspace of the cancer cells or via exhaled breath. LCAOS will: (i) develop arrays of chemically-sensitive field effect transistors (FETs) of non-oxidized, molecule-terminated silicon nanowires (Si NWs); (ii) test the ability of these devices to sense volatile LC biomarkers from in-vitro tissue, and exhaled human breath; (iii) study the signal transduction mechanism of the volatile biomarkers, using pattern recognition; (iv) improve systems to enable the NaNose to distinguish the targeted biomarkers from environmental clutter, using methylation, expression profiling, and genome-wide sequencing; and (v) perform clinical-related studies to assess LC conditions in actual patients & tissues, and in the presence of real-world confounding signals. Validation will be carried out by clinician partners and professional mathematicians and computer scientists. Resources will also be allocated to ensure the commercial potential of the sensor device layout.",A Nanoscale Artificial Nose to easily detect Volatile Biomarkers at Early stages of Lung Cancer and Related Genetic Mutations,FP7,31 March 2015,01 April 2011,4140174.0 LEAP TOMOGRAPHY,Technion Israel Institute of Technology,transport,"The research proposed is part of an extensive work aimed at investigating the formation of defects during the solidification of Nickel-based superalloys, where the goal is establishing criteria that enable avoiding their formation. We intend to employ the latest version of the Atom-Probe Tomograph, namely the Local-Electrode Atom-Probe (LEAP), which is the best analytical experimental tool available today for characterizing the chemistry of solid materials in the sub-nanometric scale. The results obtained by LEAP will be used as input data for ab-initio Molecular Dynamics (AIMD) simulations and compared with nano-mechanical testings. The approach of combining both LEAP tomography results with mechanical behavior in the nano-scale, as well as implementing AIMD, may serve as a very powerful tool in the understanding of materials science fundamentals, e.g. the correlation between mechanical properties, composition, and morphology. Specialization in the most powerful atomistic-tomography tool known today, the LEAP, is essential for preserving the high level of scientific research in Israel, thus encouraging further scientific collaboration between Israel and other EU countries as well as the USA. We intend to perform the LEAP characterization work as well as the analytical modeling at the Northwestern University Center for Atom-probe Tomography (NUCAPT) leaded by Prof. David Seidman. The rest of the research work including Transmission Electron Microscopy (TEM) as well as computer-aided simulations will be performed in the return stage at the Technion, Faculty of Materials Engineering, and leaded by Prof. Wayne Kaplan.",Exploring the three-dimensional nanoscale space around defects in Ni-based superalloys for aircraft applications employing atom-probe tomography,FP7,07 January 2011,03 January 2008,242235.88 LEC&LIP2INVADE,Albert Ludwigs University of Freiburg * Albert-Ludwigs-Universität Freiburg,health,"Pseudomonas aeruginosa has emerged as a major opportunistic pathogen during the past century. The invasion of host cells plays a fundamental role in the pathogenesis of this bacterium. As clinically important antibiotic resistance of P. aeruginosa continues to increase, the identification of host as well as microbial factors essential for P. aeruginosa uptake may lead to new drug targets. Our highly ambitious and interdisciplinary research project at the interface of biology, chemistry and physics aims at describing the molecular mechanism of the internalization of P. aeruginosa in non-phagocytic cells. Based on novel concepts that we have established for some bacterial toxins and animal viruses, we hypothesize that specific interactions of the P. aeruginosa lectins LecA and LecB with distinct glycosphingolipids exposed at the host cell surface lead to formation of plasma membrane invaginations, activation and recruitment of signaling molecules, cytoskeleton remodeling and cellular uptake of the bacterium. In order to acquire highly complementary results and to ensure the maximal outcome, we will perform our studies on diverse animal cells and various membrane model systems in combination with super resolution imaging techniques, biochemical and screening approaches. For the in vitro reconstitution of bacterial invasion, we will develop a unique platform for membrane nanoscopy based on planar pore-suspending membrane systems of different complexity (e.g. pore-suspending plasma membrane sheets and synthetic lipid bilayers). We expect to be able to identify key factors of bacterial uptake and small molecule inhibitors towards them in order to develop new therapies against the pathogenesis of P. aeruginosa infections.","The interactions of the Pseudomonas aeruginosa lectins LecA and LecB with glycosphingolipids result in membrane invagination, signaling and cellular uptake of the bacterium",FP7,30 November 2016,01 December 2011,1436400.0 LEEP-NANO-ASTRO-RAD,The Open University,health,"In the past decade, it has become increasingly recognized that low-energy electrons (LEE) play a key role in a large number of fundamental and applied fields. Electrons with energies in the range 0-30 eV can induce, at interfaces and surfaces, specific reactions which are relevant to nanolithography, dielectric aging, radiation waste management, radiation processing, astrochemistry, planetary and atmospheric chemistry, surface photochemistry, radiobiology, and radiotherapy. For more than 30 years, the action of LEE at the surface of molecular and biomolecular solids has been investigated in the laboratory of the applicant with model systems consisting of pure or doped thin molecular films. The purpose of the present application is to develop a research program within the European Union (EU) to investigate systems of relevance to three important applications of LEE processing, namely nanolithography, astrochemsitry and radiotherapy. In particular we plan (1) To investigate LEE-induced reactions of selected molecules on metallic surfaces so as to assess their potential for STM beam lithography. (2) To study the possibility of inducing specific chemical reactions with the photoelectrons. (3)To investigate LEE-induced reactions in ice mantles that simulate both planetary and ISM conditions. (4)To investigate LEE-induced damage to DNA incorporating the radiosensitizers Carboplatin and Gemcitabine with and without added water. (5)To obtain cross sections for DNA damage with and without the presence of these radiosensitizers by analysing the dose to yields relationship during LEE bombardment of DNA. Since the IIF is one of world's leading researchers in such LEE processes it is also intended to exploit his fellowship to provide valuable training and leadership amongst the younger members of the EU LEE community at a time when a new generation of researchers is emerging in the field.","Investigation of condensed-phase low-energy (0-30 eV) electron induced processes for application to nanolithography, astrochemistry and radiotherapy.",FP7,03 November 2010,04 November 2008,243268.0 LENS,Micron Semiconductor Italia Srl,manufacturing,"Water immersion lithography has been widely accepted as patterning technology for the 45nm technology node, but solutions for the patterning of 32nm and 22nm technology nodes are not clear yet.",Lithography Enhancement towards Nano Scale,FP7,12 January 2011,01 January 2009,0.0 LICARA,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,environment,"Nanomaterials have a great market potential for SMEs due to the high added values and the reduced batch sizes compared to their corresponding conventional bulk materials. Unless the benefits the introduction of nanomaterials is hampered due to the unknown human and ecological risks. It may take many years to fill all knowledge gaps. However, the SMEs have to address the various different aspects and perceptions of risks, in communication with the various stakeholders. For this reason, SMEs need guidance to assess the risks and the benefits of their nanoproducts in comparison with the conventional (non-nano) products.","Life cycle approach and human risk impact assessment, product stewardship and stakeholder risk/benefit communication of nanomaterials",FP7,09 June 2016,10 January 2012,0.0 LICRYSTG,Heidelberg University * Ruprecht-Karls-Universität Heidelberg,energy,"Li-based olivine phosphates exhibit an enormous potential for applications such as next-generation cathode materials for Lithium-ion batteries and for faster and more reliable data storage devices. A fundamental understanding of this extremely promising class of materials however demands single-crystals which allow to study intrinsic material properties and the interactions between intrinsic electronic and structural properties on the one hand and kinetics, domain effects and electrochemical performance on the other hand. The aim of the proposal is hence to synthesize and to investigate high quality single crystals of these materials for studying (1) anisotropic parameters relevant for applications in Lithium-ion batteries for different crystal directions, and (2) the ferrotoroidicity of the grown crystals for potential applications in data storage. In order to achieve this aim, a unique high-pressure traveling-solvent floating zone furnace will be applied which allows single crystal growth of Li-based systems under external pressure of 150 bar. The outcome will be the growth of hitherto and with conventional methods not accessible high-quality single crystals with large sizes, quantitative information about relevant intrinsic materials parameters such as anisotropic electronic conductivity and Li diffusion, and proper understanding of the ferrotoroidal properties in Li-based olivine phosphates. The main experimental work will be performed at U Heidelberg and ETH Zürich. The project results will yield valuable information for optimizing and tailoring nano- and microstructured Li-ion battery materials as well as on the potential of ferrotoroidicity for data storage, thereby providing an opportunity to European industry in cutting-edge technologies.",Single-crystalline Lithium-based model systems of future materials for electrochemical energy storage and data storage,FP7,30 September 2015,01 April 2013,223778.0 LIDWINE,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,health,"The project focuses on the development of multifunctional medical textiles to prevent wounds (such as Decubitus) on one hand and stimulate wound healing on the other hand. Three different approaches will be followed: 1. blood circulation stimulation: a textile-based massage cuff will be realized in which electric field sensitive contractive polymers are integrated. Alternatively electro-pulsed muscle stimulation will be realized by a textile integrated electrodes-circuits. 2. reduction of skin-textile friction: nano-coatings will be developed with this property based on brush-nanocoatings. 3. development of anti-bacterial textiles with controlled moisture management. Basic anti-bacterial properties will be realized by application of specific biopolymers and functionalized nanoparticles produced and applied by ultrasound. Additionally controlled (both initiation and rate of release) drug release will be developed in which the release will be controlled by an enzymatic switch. In this approach integration of the different systems developed will be an important issue for optimal performance. All products from the 3 approaches will be technically validated and evaluated in practise (hospitals). This project will contribute now, and in the future where people become older, to a substantial reduction in the medical cost by reduction of recovery days and by prevention (beyond 40 billion Euro/annum in Europe).",Multifunctionalized Medical Textiles for wound (e.g. Decubitus) prevention and improved wound healing,FP6,31 August 2010,01 September 2006,6000000.0 LIFELOOP,Imego AB,health,"In a rebreather system exhaled breathing gas is collected in a counterlung and can be inhaled again after a recycling process, where CO2 is removed and metabolised O2 is replaced. Rebreathers are used by rescue services (fire fighters, smoke divers, miners), in medicine (anaesthesiology, O2 rebreathers for emergency treatments) and in diving. The ability of a closed circuit rebreather to provide a life sustaining gas depends on the correct function of each component. The main bottlenecks in present rebreather units are O2 sensing (electrochemical sensors) and the chemical CO2 removal. The scientific objectives of this proposal address on the one hand the research and prototyping of a novel paramagnetic microfabricated silicon O2 sensor. On the other hand an innovative and reusable nano technology based CO2 filter (nano porous fibres, polymer nanofibres) will be developed. Based on these components a prototype of a rebreather unit will be designed and characterized. The proposed work will be carried out at Imego, Sweden. Arne Sieber will receive intensive training in the fields of: - silicon micofabrication, MEMS design, fabrication and characterization - nanotechnologies, especially application and treatment of nano propos hollow fibres/polymer nanofibres Furthermore it is envisaged that he will be able to enhance his management, leadership, teaching and presentation skills.",Microfabricated Silicon Oxygen Sensor and Reusable Nano Technology Based Carbon Dioxide Filter for Life Supporting Closed Loop Respiratory Equipment,FP7,24 March 2012,01 May 2009,171466.0 LIGHT,University of Leuven * Katholieke Universiteit Leuven,environment,"Optimization of catalytic materials and hence of chemical processes heavily relies on gaining detailed insight into the complex dynamics underlying the outcome of a catalytic process and using this information in the rational design of improved catalysts. So far, spectroscopic approaches have already contributed importantly; however a strong need for new and improved in situ spectroscopic methods with micro- and nanometer resolution still remains. This project aims to develop advanced light microscopy tools that will significantly contribute to this goal.",advanced Light mIcroscopy for Green cHemisTry,FP7,09 June 2019,10 January 2012,1999485.0 LIGHT INDUCED SWITCH,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Molecular framework materials recently have been shown to possess immensely rich host-guest chemistry; their porous lattices are capable of highly selective host-guest properties that include reversible guest and ion exchange, heterogeneous catalysis, and gas storage and separation. It was realized that by further exploitation of the porous nature of metal-organic frameworks in combination with spin crossover centres, molecular sensing materials can be generated, whereby the spin crossover sites can be switched 'on', 'off' or altered by the presence, absence or exchange of solvent guest molecules. The challenge in this exciting new area is to generate such materials with a focus on real and timely application. Light is one of the most promising ways to reversibly direct and control the physical properties of organic and inorganic materials. Spin crossover materials are a convenient class of compounds to make this possible as they are known to exhibit a light induced transition from a low spin to metastable high spin state, and indeed can show infinite lifetimes of the high spin state under certain conditions. The overall object of this proposal is to develop inorganic nanoporous materials and supramolecular clusters which have inbuilt light initiated switches, in the form of iron(II) spin crossover centers, for use as optical switches and storage devices, molecular sensors, chemical detectors, drug delivery, data storage, displays and other electron devices. The project makes use of the complementary skills and expertise of the research groups in Bordeaux, Melbourne and Sydney to achieve the first detailed investigations of this novel co-existence of spin crossover and nanoporous materials towards 'nano-scale' light initiated switching applications. The impact of even a small advance in such materials could translate into a major impact on the environment, economy, public health and national security.",Nanoporous Materials and Supramolecular Clusters for Light Induced Electronic Switches,FP7,31 October 2009,01 November 2008,82388.0 LIGHT-ROLLS,Fundacion PRODINTEC,energy,"Light-Rolls focus on research and development of modular based production units for the seamless, high throughput manufacture of micro-structured, polymer based components and Microsystems. The scientific objective aims to realize structures in the micron range and integrate also Dies, smaller then 0,5mmx0,5mm and thickness down to 50 um to be assembled in high-speed. Nanopar-ticulate dispersions used in fast conductive track printing technologies will allow the parallel gen-eration of conductive lines down to 30µm track width. Light-Rolls is based on highly innovative manufacturing and assembly technologies: 1. RMPD®-rotation, a patented process technology, which uses a UV curable liquid to generate polymer structures (generative manufacturing approach). 2. New chip assembly methods, originating from self assembly methods 3. High resolution -high speed conductive track and interconnection generation by ink-jet printing methodologies. These processes comprise the founding elements of the Light-Rolls technology platform with a roll-to-roll philosophy. The manufacturing modules will be integrable, exchangeable, with mechanical, fluidic and IT interfaces, to make it easy and cost efficient to adjust the sequence of process steps to the product to be produced. Besides the translation of processes for high-throughput manufacturing, high yield will be achieved by the application of advanced process control and production IT meth-ods. Lines run without dangerous chemicals and use integrated recycling. For future products a Light-Rolls knowledge base for design for manufacturing will be elaborated. A pilot line will be set-up, tested for fabrication of flexible LED-display systems. Manufacture of other components like Lab-on-Chip or integration of new micro-energy storage components is possible in future to address needs of European industry. Products have potential of 100 Mio Euro worth revenue for 1 partner alone for a 5 year period beyond project end.",High-throughput production platform for the manufacture of light emitting components,FP7,31 December 2012,01 July 2009,3748323.0 LIGHT2NANOGENE,University of St Andrews,health,"The use of nanoscience technologies to either perform therapy or diagnosis at the cellular level is expected to revolutionize 21st Century medicine by opening new approaches to cure various illnesses. However, cellular bioengineering is technologically challenging and becomes feasible only when different scientific disciplines are combined together to provide advanced cellular level surgery tools. To this aim, nanosurgery (i.e., surgery on the nanoscale) employs ultrafast laser technology and/or nanoscience emerging technologies (nanophotonics, nano-engineering, plasmonics etc.) to perform cell or even nucleus surgery. The major advantage of the nanosurgery approach is the prospect to disrupt submicrometer-sized organelles within living cells or tissue without affecting the surrounding material or compromising viability of the cell or organism. In this context, we intend to apply and optimize a novel femtosecond laser technique for nanosurgery of cancer cells. The technique, named plasmonic enhanced laser nanosurgery, combines the advantages of two rapidly expanding research and technological fields, namely plasmonics and ultrafast lasers, to build a versatile tool capable of performing high throughput cell nanosurgery. The main innovative goal of the proposal involves optical fiber integration of the plasmonic nanosurgery tool towards in-vivo (i.e. living subject) applications. In-vitro cell transfection (i.e., introduction of siRNA through the membrane of breast cancer stem cells (CSCs)) is the specific nanosurgery application of the Light2NanoGene project. The latter, is driven by the remarkable ability of these undifferentiated cells within a tumor to self-renew and promote metastases. The successful transfection of the CSCs with siRNA will silence the expression of key genes involved in their aggressive behavior. We expect proof-of-concept elimination of their capacity for self-regeneration and induction of metastases.",Cellular bioengineering by plasmonic enhanced laser nanosurgery,FP7,31 March 2017,01 April 2014,283489.0 LILAC,University of Bristol,health,"The overall purpose of this research project is to develop and apply a novel laser-initiated liquid-assisted colloidal lithography (LILAC) method for controllable nanostructuring a wide range of surfaces. The method combines, for the first time, ultra-short laser pulses, medium-tuned optical near-field effects and colloidal lithography to achieve surface structuring of materials like Si, III-V semiconductor, biomedically relevant metals and polymer surfaces. The detailed mechanisms underpinning the pattern formation depend on the many experimental process variables: laser wavelength and intensity/fluence; choice of liquid; size, shape, nature and packing of colloid particles; choice of solid surface, etc. Accordingly, the 2-year project proposed here has three interconnected aims: 1. To investigate the mechanisms of the pattern formation by systematic variation of relevant experimental parameters. To this end, we will vary: the nature of the liquid used to produce radical species at the liquid-substrate interface, laser pulse duration and wavelengths, the colloidal lithographic masking strategy, substrate surface chemistry, etc.; 2. To exploit the LILAC method to generate surface patterns with unprecedented physical and chemical sophistication and complexity; 3. To undertake preliminary investigations of the utility of specific surface micro-structures for tissue engineering and sensor applications. This project will help Dr. Magdalena Ulmeanu to embark upon an independent research career and to acquire new practical and theoretical skills necessary for her career development in ultra-short laser processing of surfaces.",Laser-Initiated Liquid-Assisted Colloidal Lithography,FP7,29 February 2016,01 March 2014,299558.0 LIMA,Polytechnic University of Valencia * Universitat Politècnica de València,energy,"The LIMA project exploits cutting edge photonic technologies to enhance silicon solar cell efficiencies with new concepts in nanostructured materials. It proposes nano-structured surface layers designed to increase light absorption in the solar cell while decreasing surface and interface recombination loss. Integration in a back contact design further reduces these interface losses and avoids shading. The project improves light-matter interaction by the use a surface plasmonic nanoparticle layer. This reduces reflection and efficiently couples incident radiation into the solar cell where it is trapped by internal reflection. Surface and interface recombination are minimised by using silicon quantum dot superlattices in a passivating matrix. The distance between quantum dots ensures wave-function overlap and good conductivity. An effective field at the superlattice - crystalline silicon interface ensures that the cell is insensitive to the recombination velocity at this heterojunction, and further increases the collection probability in the quantum dot layer. The dots allow a fundamental efficiency enhancement due to experimentally confirmed multiple exciton generation. This mechanism increases photocurrent and can in theory raise the theoretical single junction efficiency limit from 33% to 44%. These surface plasmonic and quantum dot layers are integrated in a high efficiency crystalline silicon back contact cell. This is designed such that the space charge region is separated from the superlattice -crystalline silicon heterojunction minimising non radiative space-charge recombination. The back contacts and dielectric electrical insulator are designed to maximise back surface reflection and enhance the light trapping of incident radiation without shading losses. The project combines expertise between academic and industrial partners. The goal is a high efficiency cell using novel concepts to enhance proven cell designs.",Improve Photovoltaic efficiency by applying novel effects at the limits of light to matter interaction,FP7,31 December 2012,01 January 2010,2375000.0 LIMACONA,University of Bath,photonics,"The academic exchange aims to establish and support multi-lateral transfer of knowledge among several European research teams and teams from Russia, Ukraine and Armenia, striving to advance the research on Physics of Light-Matter Coupling in Nanostructures. This programme will combine unique expertise of partners in Nonlinear Physics and Optics, Materials Science, Nanoscience and Nanotechnology, Computer Science, to perform theoretical and experimental research on formation, manipulation and collective dynamics of coupled matter-field states -exciton-polaritons -in photonic crystals, atomic and semiconductor bandgap structures. New methods to produce composite materials and low-dimensional structures integrated with semiconductors will be developed, including nano-structuring of semiconductor films and granular metal films on the surface of semiconductor hetero-structures, synthesis of semiconductor materials in nano-porous dielectric matrices. Specific features of polaritonic spectra and dynamics in these structures will be studied, and the local enhancement of light-matter coupling due to nano-structures will be analyzed. New methods of manipulation of coupled matter-field states at polariton level for quantum and classical optical information processing and storage will be developed. During this project, several local research links already established between participating organisations will be brought together on the whole new level to form the functional research network. The complementary expertise of all the parties in this network will be crucial to tackle the cross-disciplinary scientific problems associated with studies of light-matter coupling in nano-structures. Formation of this network represents an enormous added value for the research within the individual groups and at the European level.",Light-Matter Coupling in composite Nano-Structures,FP7,30 September 2016,01 October 2013,248900.0 LIMPID,National Research Council * Consiglio Nazionale delle Ricerche (CNR),environment,"Limpid aims at generating new knowledge on photocatalytic materials and processes in order to develop novel depollution treatments with enhanced efficiency and applicability. The main goal of LIMPID is to develop materials and technologies based on the synergic combination of different types of nanoparticles (NPs) into a polymer host to generate innovative nanocomposites which can be actively applied to the catalytic degradation of pollutants and bacteria, both in air or in aqueous solution. Single component nanocomposites including TiO2 NPs are already known for their photocatalytic activities. LIMPID will aim at going one big step further and include, into one nanocomposite material, oxide NPs and metal NPs in order to increase the photocatalytic efficiency and allow the use of solar energy to activate the process. One of the main challenge of LIMPID is to design host polymers, such as hybrid organic inorganic and fluorinated polymers, since photocatalysts can destroy the organic materials. The incorporation of NPs in polymers will allow to make available the peculiar nano-object properties and to merge the distinct components into a new original class of catalysts. At the same time nanocomposite formulation will also prevent NPs to leach into water and air phase, thus strongly limiting the potential threat associated to dispersion of NPs into the environment. Therefore nanocomposites developed in LIMPID will be used as coating materials and products for the catalytic degradation of pollutants and bacteria in water and air, i.e. deposited onto re-usable micro-particles, or in pollutant degradation reactors, and even onto large surfaces, as a coating or paint. In addition such new class of nanocomposites will be also exploited for the fabrication of porous membranes for water treatment. In order to fulfill its objectives, the LIMPID consortium has been designed to combine leading industrial partners with research groups from Europe, ASEAN Countries and Canada.",Nanocomposite materials for photocatalytic degradation of pollutants,FP7,11 June 2017,12 January 2012,3299469.0 LINASS,University of Cambridge,energy,"NanoMaterials have huge promise in a wide range of applications of societal importance. Intricate combinations of metals, semiconductors, dielectrics, and molecular components in three-dimensional configurations, have new and unusual properties. Such advanced functions are at the heart of photovoltaics, magnetic and quantum information technologies, photosynthesis, water splitting, electronics, batteries, fuel cells, catalysis and many more crucial areas. Despite much research, we simply cannot yet make such nanomaterials at will. This problem is thus a major challenge for the future decades that we need to solve. The proposal here uses bottom-up assembly of nano-components combined with the application of controlling beams of light, as a new approach to sub-nm precision capable of scale-up. The exact arrangement of nano-sized components can drastically change the optical response of a nanostructure. We directly exploit this optical sensitivity to structure. Irradiation by specific wavelengths of laser light builds up strong optical fields only in parts of the structure which transiently have the right configuration. These regions of high field can be spatially localised to 1nm, far smaller than the wavelength of light. If this induces enhanced binding then optical selection preferentially selects specific morphologies. The principal goal of this proposal is to demonstrate the new strategies for reliable nano-constructs at the 1nm scale, which can be produced in large numbers with essentially identical architecture. Several approaches will be explored in parallel, using the light to either glue together nano building blocks, or to deposit the energy needed to grow nanostructures directly. In addition developing ways for light to flex structures can result in significant changes to the optical spectra, thus providing exquisitely-sensitive feedback on the nanoscale. Light is a crucial observational tool, requiring development of real-time sub-ms spectroscopies.",Light-induced NanoAssembly,FP7,31 March 2018,01 April 2013,2049999.0 LIPSYD,University Medicine of the Johannes Gutenberg-University Mainz * Universitätsmedizin der Johannes Gutenberg-Universität Mainz,health,"We have recently reported on a novel mode of modulation of neuronal transmission at the glutamatergic junction. This signaling pathway involves lysophosphatidic acid (LPA) acting via presynaptic LPA2 receptors. This is in turn controlled by a molecule which we named plasticity related gene-1 (PRG-1, Bräuer et al., Nat Neurosci 2003) from the postsynaptic side (Trimbuch et al., Cell 2009). PRG-1 is a brain-specific membrane protein related to lipid phosphate phosphatases (LPPs) with a selective expression in neurons (Geist et al., CMLS 2011). We detected an important role of LPA-synthesizing pathways in bioactive signaling at the synapse acting via ATX and etablished nano-particles as LPA-biosensor using the characteristic spectral shift allowing detection in 2-photon imaging. We provide insights into the oligomeric assembly of PRG-1 in the membrane and assessed LPA-binding, uptake and intracellular interaction partners of the molecule. Animals lacking one PRG-1 allele exhibit a broad spectrum of behavioral pathology indicative of altered brain network function and psychiatric disorders. These changes are already present in animals lacking only 50% of PRG-1. A point mutation at R345T which appears to result in loss-of-function when re-expressed in the mouse was found in 5925 healthy individuals with a heterozygous frequency of approximately 0.86% (about 4.500.000 European citizens). Individuals carrying this loss-of-function mutation revealed functional alterations of sensory gating involved in psychiatric disorders. We plan to continue our studies on (1) synthesis and action of LPA, (2) molecular function of PRG-1 in bioactive lipid signaling, and (3) the role of PRG-1 signaling in brain network function and psychiatric disorders. Characterization of the molecular basis of this novel modulatory signaling pathway and its role in brain network function will be important for our understanding of its role in health and disease.",Lipid Signaling at the Glutamatergic Synapse: Involvement in Brain Network Function and Psychiatric Disorders,FP7,31 March 2018,01 April 2013,2499390.0 LIQUIMEM,University of Rostock * Universität Rostock,environment,"Downstream processing is still one of the major challenges not only for chemical and biotechnological production processes, but also for wastewater treatment. Very often the treatment of aqueous process streams, which typically are obtained from biotransformations or from wastewater treatment, is necessary for the removal of either hydrophobic or hydrophilic compounds, which may be present at various concentration levels. The present proposal aims to combine recent developments in the field of membrane technology such as nanofiltration, liquid membranes or pervaporation with the use of ionic liquids for providing novel solutions for downstream processing or process intensification.The major objective of the project is to investigate the development and application of supported liquid membranes on the base of ionic liquids. When using liquid membranes the selectivity of the separation is not based on the solid support of a given membrane, but on the properties of the liquid. Liquid membranes offer a range of possible advantages, such as better control of the selectivity. The compounds to be separated may be products of biotransformations and fermentation processes or renewable materials. Compounds of interest are carbohydrates, chiral alcohols and amines and more complex metabolites, such as antibiotics. The potential of these new types of liquid membranes will also be tested for e.g. extraction of heavy metals from aqueous streams (wastewater).The potential of ionic liquids in combination with pervaporation shall be explored. First results indicate that volatile compounds can be removed from ionic liquids by pervaporation. Due to their negligible vapour pressure and relatively high viscosity ionic liquids may be used as pervaporation membranes. Together with the tunability of their solvation properties this will allow to improve the selectivity of this new type of pervaporation membrane.",Liquid Membranes and Ionic Liquids for Selective Downstream Processing,FP6,31 January 2007,01 February 2005,158198.0 LISF,Technische Universiteit Eindhoven * Eindhoven University of Technology,energy,"One of the greatest challenges facing the electric power industry is how to deliver the energy in a useable form as a higher-value product, especially in the area of renewable energy. By storing the power produced from immense renewable sources off-peak (e.g., daytime for solar energy) and releasing it during on-peak periods, energy storage can transform low-value, unscheduled power into high-value 'green' products. The development of high-energy and high-power storage devices has been one of the research areas of top-most importance in recent years. Lithium batteries currently have the highest energy storage density of any rechargeable battery technology. Their behavior is based on the classical intercalation reaction during which lithium is inserted into or extracted from both cathode and anode. Huge volume changes are associated with this process, often resulting in disintegration of the material. Exploration of nanostructure is one of the encouraging research directions in order to avoid materials failure. Experiments suggest that size reduction is an effective strategy in creating fracture resistant electrodes. Using a combination of diffusion kinetics available in the literature and fracture mechanics, the first part of project aims at giving insights on the critical size for flaw tolerant nano-structured battery electrodes. Approximated analysis of crack coalescence and debonding at the interface between active particles and porous electrodes will be achieved by means of new ad-hoc multi-physics cohesive interfaces. Since effects at different scales are involved during charge/discharge cycles, the simulation of the mechanical response of Li-Battery systems requires a multi-scale approach. The second part of the project aims at enriching current computational homogenization techniques - originally developed in the framework of elasticity for heterogeneous materials - as a tool to model the electrochemical-mechanical interactions in lithium batteries.",Mechanics of Energy Storage Materials: Swelling and Fracturing in Lithium ion Batteries electrodes during Charging/Discharging Cycles.,FP7,28 August 2014,29 April 2013,170046.0 LISSEN,Consorzio Sapienza Innovazione,environment,"This project is aimed to the identification and development of nanostructured electrode and electrolyte materials to promote the practical implementation of the very high energy lithium-sulfur battery. In particular, the project will be directed to the definition and test of a new, lithium metal-free battery configuration based on the use of lithiated silicon as the anode and a nanostructured sulfur-carbon composite as the cathode. It is expected that this battery will offer an energy density at least three times higher than that available from the present lithium battery technology, a comparatively long cycle life, a much lower cost (replacement of cobalt-based with a sulfur-based cathode) and a high safety degree (no use of lithium metal). All the necessary steps for reaching this goal are considered, starting from material synthesis and characterization, exploiting nanotechnology for improving rate capability and fast charging, the fabrication and test of large scale prototypes and to the completion of the cycle by setting the conditions for the recycling process. A team of experts have been selected as partners of the project, including a number of academic laboratories, all with worldwide recognized experience in the lithium battery field, whose task will be that of defining the most appropriate electrode and electrolyte nanostructures. The project will benefit by the support of a laboratory expert in battery modeling to provide the theoretical guidelines for materials’ optimization. Large research laboratories, having advanced and modern battery producing machineries will be involved in the preparation and test of middle size battery prototypes. Finally, chemical and battery manufacturing industries will assure the necessary materials scaling-up and the fabrication and test of large batteries and particular attention will be devoted to the control of the safety and to definition and practical demonstration of its most appropriate recycling process.",Lithium Sulfur Superbattery Exploitating Nanotechnology,FP7,08 July 2017,09 January 2012,2579940.0 LIVEBIOMAT,Leipzig University * Universität Leipzig,health,"The development of new polymeric biomaterials designed to stimulate specific cellular responses at the molecular level such as activation of signalling pathways that control gene activity involved in maintenance, growth, and functional regeneration of liver tissue in vitro could be an important step in tissue engineering. The project is aimed to the development of polymeric synthetic and biodegradable biomaterials to control liver cell responses in vitro and in vivo systems. Isolated hepatocytes are able to continue the full range of known in vivo liver specific functions for only a short time. The in vitro maintenance of competent hepatocytes is decidable so that the liver functions can be studied in a controlled environment. Engineered liver tissue constructs may provide an inexpensive and reliable in vitro physiological model with great control of variables for studying disease, drug, infection and molecular therapeutics. New modified polyetheretherketone PEEK-WC membranes will be prepared in hollow fiber configurations. Membranes will be prepared by phase inversion technique, which permits to obtain membranes with various structural properties by means of kinetic and thermodynamic parameter control. In addition, the development of synthetic polymeric materials consisting of nanofiber network scaffolds represents an entirely new approach to tissue engineering that has relied in the past on materials that where either of unknown composition (i.e. Matrigel) or not possible to design (i.e. Collagens). Thus, the design and preparation of synthetic three-dimensional nanofiber network scaffolds that highly mimic the extracellular matrix will be a valuable tool in the field. The surface of membranes/scaffolds to be utilized in the project will be modified by non equilibrium plasma-chemical processes such as Plasma Deposition of thin films (PE-CVD) and Plasma Treatments to adapt their properties to the best compatibility with cells.",Development of new polymeric biomaterials for in vitro and in vivo liver reconstruction,FP6,30 September 2008,01 April 2005,2299906.0 LIVENUCESC,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"Owing to their unique ability to self-renew indefinitely, as well as their capacity to differentiate into multiple cell types of all three germ layers, embryonic stem (ES) cells hold great promise both as therapeutic agents in the clinic and as research tools in the lab. One of the main challenges in the field is understanding how stem cells achieve their remarkable potential. Recent efforts by us and others have shown that chromatin itself serves as a major contributor to ES cell identity and plasticity. While most of the supporting data emerges from biochemical and molecular studies, I propose here to use live cell imaging techniques and advanced microscopy to probe the transcriptional machinery and chromatin dynamics in living differentiating ES cells. I aim to elucidate the dynamic changes that occur in chromatin structure and function during early ES cell differentiation events. Using photobleaching methods (i.e. FRAP) complemented by biochemical approaches, I will study the dynamic interplay of both transcriptional activators (e.g. Oct-4, Nanog) and transcriptional repressors (e.g. Polycomb Group proteins) with chromatin. Also, using the spinning disk confocal technology I will monitor in real time, changes in chromatin structure, as well as the dynamics of chromatin-protein interactions in living cells. Finally, using ES cell lines carrying a labeled genomic locus at random sites I will be able to directly visualize chromatin motion in living cells. These experiments will provide new insights into the mechanisms that govern chromatin-regulated differentiation events and chromatin dynamics in living cells as well as stem cell identity and pluripotency.",Live imaging of nuclear dynamics in embryonic stem cell differentiation,FP7,30 November 2011,01 December 2007,100000.0 LOCCANDIA,Atos Spain SA,health,"The human plasma proteome holds the promise of a revolution in disease diagnosis and therapy. One major breakthrough should come from the detection of multiprotein disease markers including isoforms. We propose to integrate a full proteomics analysis chain, from blood sample to the diagnosis information, combining bio-, nano, and information-related technologies. It includes an innovative patented lab-on-chip developed at CEA. The clinical application is early pancreatic cancer diagnosis. The project is based on a panel of 3 identified proteins, a protein isolation protocol, an optimised chromatographic-electrospray lab-on-chip, an Integrated Clinico-Proteomics Environment including a Proteomic Information Management System, a Clinical Information System, and modules for preprocessing, reconstruction, visualisation, protein identification, data mining and knowledge discovery. The clinical validation is applied to a cohort of 92 patients. Our targeted performance is to get at least the sensitivity of an orthogonal ELISA approach, to operate the analysis chain in less than 12 hours, and to demonstrate the interest of multiprotein marker. The main research outcomes will be an optimised chromatographic-electrospray lab-on-chip, a software environment supporting the integrated device, a proof-of-concept of their application to protein profiling for cancer diagnosis and an exploitation plan. The roadmap of this 36 months project is defined according to three main milestones: 1) at month 12, a first protein profile using a first version of the lab-on-chip on artificial samples is available, 2) at month 24, all the final versions of the sub-systems are ready for integration and validation, 3) at month 33, the validation on clinical samples is completed. The consortium partnership involves partners over 5 countries, combining basic and applied research (CEA, FORTH, SIB, WWU), 1 large company (ATOS) and 2 SMEs (BVN, GB), including clinicians and end-users (WWU, BVN).",Lab-On-Chip based protein profiling for CANcer DIAgnosis,FP6,30 November 2009,30 May 2006,2651776.9 LOCNANOMOT,University of Alcalá * Universidad de Alcalá,health,"The IOF project LOCNANOMOT aims to design new miniaturized Lab-on-a-Chip systems for multiplexed detections using functionalized artificial micro/nanomotors modified with different receptors. To achieve this goal, a primary challenge of the outgoing phase (University of California, San Diego, USA) is the development of new receptor-functionalized catalytic micro/nanomotors capable of performing multiple nanoscale operation. The second goal will be focus on the integration of the newly developed micro/nanomotors into LOC devices. These evaluations not only contribute to the development of new LOC formats with a wide range of medical and analytical applications, but will also train the Fellow in novel and powerful research techniques. Therefore, this fellowship will provide the applicant with high level skills, which will be transferred to the return phase (University of Alcalá, Spain) in the third year, fulfilling the objectives of the 'Outgoing International Fellowship'. In this context, the primary goal of the return phase will focus on the applicability of these new devices for the isolation and detection of contaminants in foodstuffs. This project addresses one of the main thematic areas of the European Research Area of the FP7 (Nanoscience, Nanotechnology, materials and new production technologies) and is highly related to others (health and food, agriculture and biotechnology). The innovative character of this proposal lie in the integration of the active transport properties of nanomachines in LOC systems. This novel systems will lead to future new biomedical, analytical and technological applications in pathogen detection, clinical diagnosis, forensic science, DNA analysis, food safety, etc. On overall, the project will advance the development of new LOC devices, well beyond the state of the art, and will contribute to increasing European Research Area excellence and competitiveness.",New lab-on-a-chip microsystems based on active transport by synthetic micro/nanomotors,FP7,31 July 2016,01 August 2013,254925.0 LODIHYBRIDS,Joseph Fourier University * Université Joseph Fourier,information and communications technology,"Technological progress has lead to a huge growth in the field of mesoscopic physics over the past decade, and buzzwords like spintronics or quantum computing have created much excitement. At the origin of this development is the ongoing miniaturization and the ever increasing control over systems at the nanoscale. Central elements in understanding mesoscopic systems are the reduced dimensionality as well as the interplay of interactions and disorder. Luttinger liquid theory has been very successful in describing the low-energy properties of clean onedimensional systems. With the advent of more and more precise measurements, the question as to the limitations of Luttinger liquid physics has arisen only fairly recently. The proposed research explores (quasi-)onedimensional physics beyond the Luttinger liquid description, focusing on deviations from onedimensionality in interacting quantum wires and the interplay of interactions and disorder. Hybrid systems offer new ways of designing system functionality by combining materials with different, even antagonistic properties. A prime example are superconductor-ferromagnet systems where the incompatibility of the spin properties leads to a number of unusual phenomena. The proposed research explores correlations and dynamic (spin) effects in hybrid systems. Finally, ultracold atomic systems have opened a new window on interacting quantum systems. Since the first realization of Bose-Einstein condensation of a gas of bosonic atoms, ultracold atom physics has rapidly evolved. Pairing of fermions has been observed with the analogue of two spin states realized using two different hyperfine states. One of the most exciting features of these recently discovered atomic paired-fermion superfluids is the tunability of the interactions via a magnetic field-induced Feshbach resonance. The proposal considers ultracold gases in an inhomogeneous magnetic field to explore aspects of (quasi-)onedimensional and hybrid systems.",Correlations and Proximity Effect in Low-Dimensional and Hybrid Structures,FP7,02 April 2017,03 January 2011,100000.0 LORENTZ WORKSHOPS I,Universiteit Leiden * Leiden University,information and communications technology,"This project embodies four workshops on topics in which Europe has a strong interest and provide advanced training in modern topics in mathematic and computer science. The workshops in this series of events cover collective dynamics and new computational developments: Workshops 1 and 4 deal with topics in the development of information technologies, network stability and quantum computing, while workshop 2 addresses the theme of mathematical proofs of algorithms used widely in computer algebra. Workshop 3 is dedicated to the mathematical description of complex biological and biochemical systems from cells to the spread of diseases. The approach is creative and combines input from otherwise separated research areas. Thus coming together at the Lorentz Center is essential to the development of the field, the advancement of the research and the possibility for young researchers to gain insight and contacts beyond their own speciality. Young eligible researchers will receive the opportunity to discuss and collaborate with leading senior colleagues: All workshops involve a mix of junior and senior participants with the participation of junior researchers normally between 30 and 50%. Co-organisation of the workshops by young researchers is promoted. The workshops are run and hosted by the Lorentz Center at Leiden University in the Netherlands, in the open and stimulating spirit for which the Center has earned its reputation.",European science workshops at the Lorentz Center. Computer science and Mathematics,FP6,30 September 2007,01 October 2006,85149.76 LORRY,Goodyear SA,transport,"The aim of the LORRY project is to reduce trucks carbon footprint by developing an innovative low rolling resistance tyre concept combined with a comprehensive tool box for fleet fuel saving management. This proposed concept will go beyond current state of art and stakeholder or market expectations regarding tyre rolling resistance, mileage, driving safety, driving performance and material and manufacturing sustainability. Steer and trailer tyres developed in the framework of the project will demonstrate a minimum 20% gain in truck tyre rolling resistance. Truck tyre wear and wet safety performance levels will be improved additionally. To reach this objective, a multidisciplinary consortium (7 public / 4 private partners) has been created covering the fields of tyre technology, rubber and filler technology, nanotechnologies, composite physics, sensory, transport and road infrastructure. A complete set of complementary scientific evaluation methods will enable the understanding of interactions between new tread pattern design and new material composites as well as the tyre performance dependency on tyre-vehicle operation and road conditions. LORRY consists in a holistic approach for an intelligent surface transport system. New tyre and truck fleet operating concepts resulting from the programmed will go beyond European Green Car Initiative roadmap expectations for 2015 and smoothly bridge and feed next coming tailored trucks and sustainable trucks initiatives, forecasted respectively for 2020 and 2025.",Development of an innovative low rolling resistance truck tyre concept in combination with a full scale simulation tool box for tyre performance in function of material and road parameters,FP7,10 July 2017,11 January 2012,2392547.0 LOTOCON,Istituto Italiano di Tecnologia (IIT),energy,"The objective of the present project is a development of approaches for facile colloidal synthesis of Cu-containing semiconductor nanocrystals, characterized by low production cost, high stability, high photoluminescence efficiency and low toxicity. The materials that will be synthesized will undergo comprehensive physico-chemical characterization including a deep assessment of their toxicity and will be evaluated as light absorbing components for fabrication of excitonic solar cells. Copper chalcogenides represented by binary, ternary and quaternary compounds, like CuS(Se,Te), CuIn(Ga)S(Se,Te), CuZnSnS(Se,Te) are one of the most attractive series of low-toxic semiconductor materials, which are truly alternative to the widely studied cadmium, mercury and lead chalcogenides. This new generation of semiconductor nanocrystals is now being in the focus of a great scientific interest. These nanocrystals are characterized by tunable visible and near infrared emission and absorption properties and high extinction coefficients and therefore hold great promise in bio applications, in light emitting diodes fabrication, photovoltaics and optoelectronics. This project will provide new knowledge into the mechanisms governing the reactions involving the various precursors during the stages of nanoparticle nucleation. This new knowledge will then allow for a proper control of nanoparticles crystal structure, composition, size, shape, and consequently of their optoelectronic and photovoltaic properties. The synthesized and fully characterized copper chalcogenide nanoparticles will be used for fabrication of solar cells. Combination and adaptation of state-of-the-art approaches as well as creation of novel synthetic methods will result in innovative investigation covering wide range of tasks from the synthesis of novel materials through their comprehensive characterization and ending with their application in photovoltaics.",Low-toxicity copper chalcogenide semiconductor nanocrystals,FP7,21 July 2014,22 July 2012,185763.0 LSV-SIE,Bar-Ilan University,health,"The field of spintronics is receiving continuous and growing attention, due to the expected increase in functions of lateral spintronics devices to include promising elements such as nonvolatile spin field effect transistors, ultra-fast memories and spin-based quantum computers. But, in order to utilize such lateral applications in industrial settings, a critical improvement in their performance is necessary, for which much basic research is still required. An important issue, which is relevant to the nano-scale lateral devices and has not received much attention, is surface effects. Here, spin scattering from the surface can lead to loss of all spin signals. The study and understanding of spin scattering, due to surface effects is one of the major goals of the proposed research. The study of lateral spintronics devices has led to discovery of many new phenomena; include spin transfer torque; crossed Andreev reflections and the spin Hall Effect. In the latter, anisotropic spin dependent scattering in non-magnetic materials induce a transverse spin current. This enables the generation of spin polarized currents in non-magnetic material without the need of injection from a ferromagnet. But, a larger magnitude of the effect is vital if one considers this a realistic source of spin-polarized current for application. We aim at increasing the spin Hall effect in metallic spintronics devices by resolving quantitatively the geometrical and material related contributions of the effect. Study of these spin transport phenomena via local probe measurements is a very powerful approach, as has been demonstrated for semiconductors using optical methods. We intend to develop and measure the local spin accumulation by an MFM-based measurement with an anticipated ~10 nm spatial resolution. This is x100 better than previous measurements, and will enable us to spatially resolve the local spin accumulation in metallic devices.",The role of surface scattering and impurities in metallic lateral Spin-valve Devices,FP7,31 August 2014,01 September 2010,100000.0 LT-NRBS,Leibniz Institute for Solid State and Materials Research Dresden * Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden eV,health,"The goal of this project is to develop new types of biosensors based on two different approaches: (i) a new bioanalytic microsystem platform for cell growth, manipulation and analysis using on-chip integrated microtubes and (ii) the use of synthetic self-propelled nanomotors for bioanalytical and biosensing applications. Based on the novel 'Lab-in-a-tube' concept, we will design a multifunctional device for the capturing, growth and sensing of single cell behaviours inside 'glass' microtubes to be employed for diverse biological applications. We will decorate the walls of the microtubes with proteins from the extracellular matrix enabling the long-term study of cellular changes such as mitosis time, spindle reorientation, DNA damage and cellular differentiation. These microtubes are fabricated by the well-established rolled-up nanotechnology developed in the host institution. Moreover, the multifunctionality of the 'Lab-in-a-tube' platform will be extended by integrating different modules into a single microtubular unit, bringing up several applications such as optofluidics(bio)sensors, electrodes for electrochemical control and sensing, and magnetic biodetection. At the IIN institute in IFW Dresden, we are pioneers on the fabrication of catalytic microjet engines (microbots) and their use for transporting different kinds of objects in vitro into a fluid. The remote controlled motion of these autonomous microbots and the transport of microobjects and cells to specific targets within lab-on-a-chip systems is possible. Their walls can be biofunctionalized with enzymes, antibodies or DNA, the catalytic microbots representing a novel and unique tool for biosensing, environmental and biomedical applications. Our next step is to use biocompatible fuels to propel these microbots with the final aim of transporting and delivering drugs in vivo.The separation of cancer cells, bacteria and other biomaterials to build up new tissues or to replace disease cells are also aimed.",Lab-in-a-tube and Nanorobotic biosensors,FP7,31 December 2017,01 January 2013,1499880.0 LUBRIJOINT,Technion Israel Institute of Technology,health,"This application is concerned with the study of the molecular basis of skeletal joint lubrication in order to improve the design of artificial joint prostheses. These joints eventually fail mainly because of problems associated with inadequate lubrication and revision surgery is an increasingly expensive burden as the population ages. A better understating of such processes should lead to better strategies for minimizing lubrication breakdown in natural joints, as well as to strategies for improving lubrication and wear of prosthetic joint implants and other biological surfaces where prevention of adhesion is required. This proposal seeks to investigate the molecular basis of the remarkably efficient lubrication in mammalian synovial joints, by constructing surfaces partly analogous in structure to that of articular cartilage and measuring forces between them under strictly controlled conditions. Using a surface force balance apparatus, we intend to measure the normal and friction forces between layers of (i) negatively charged hyaluronic acid (HA)-aggrecan (ii) lubricin and HA-aggrecan and (iii) HA-aggrecan and phosphatidylcholine-based phospholipids (PL). Firstly, a pre-biotynilated HA will be attached to mica surface via streptavidin. Aggrecan, extracted from mammalian cartilage, will be added to the HA-coated mica to form supramolecular aggregates similar to those at the cartilage/synovium interface. Secondly, a well-characterized lubricin layers and in a later stage fluorescent or radio-labeled PL will be adsorbed onto the HA-aggrecan mica surface and the interactions studied. Our ultimate goal is to address the interactions between lubricin, PL and HA -the main players in synovial lubrication. At each stage of the project, mica-attached layers will be characterized using AFM, X-ray photoelectron spectroscopy and SFB, and their tribological properties will be examined, on a nanometer scale, in a wide range relevant to physiological conditions.",Molecular Mechanism of Synovial Joint Lubrication,FP7,14 January 2014,01 June 2009,45000.0 LUNAMED,Autonomous University of Madrid * Universidad Autónoma de Madrid,health,"This proposal describes novel up converting nanoparticles that promise minimal perturbation of living systems. The work is at the leading edge of science in cell targeting, imaging and diagnostic medicine. The outgoing part will be carried out in the laboratory of Professor John A. Capobianco an internationally recognized scientist. His laboratory offers a unique, multidisciplinary environment for developing and applying novel nanoparticles in biomedicine. It includes also gain state-of-the-art expertise in nanotechnology and access to a diverse learning environment encompassing, spectroscopy, inorganic chemistry, synthesis and characterization of nanoparticles and will have access to world-class infrastructure. The incoming part of the proposal will be carried out in Prof. Daniel Jaque group, which have a great experience in optical spectroscopy as demonstrates their prolific scientific achievements.",NOVEL LUMINESCENT UPCONVERSION NANOPARTICLES FOR DIAGNOSTIC AND THERAPEUTIC NANOMEDICINE,FP7,31 July 2014,01 August 2011,210359.0 LUNGCARD,STAB VIDA - Investigação e Serviços em Ciências Biológicas Lda.,health,"Chemotherapy is the standard care for the treatment of non-small cell lung carcinoma (NSCLC) patients, however most of non-small cell lung cancer tumours are not sensitive to this treatment. As an alternative to chemoterapy, target therapy with gefitinib (epidermal growth factor receptor-tyrosine kinase inhibitor) has been used in clinical practice in patients with tumours harbouring mutations in EGFR gene, improving their treatment effectiveness. For that reason EGFR mutations analysis should be perform to support the treatment decision for a patient with NSCLC. Despite all the foreseen benefits of EGFR genotyping, the current PCR-based methods used have been shown some associated bottlenecks: i) use of complex samples (tumour biopsy embedded in Formalin Fixed Paraffin, FFPE), ii) require a better understanding from the clinical geneticist to accurately interpret the information provided and to setup the best line of therapy and treatment and iii) the assays are quite expensive and time-consuming. New age diagnostic tools, such as microfluidic platforms and nanodiagnostics are emerging technologies for DNA analysis requiring lower sample volumes and providing comparable sensitivity and specificity at lower costs. Nonetheless, sample preparation and detection of the result of a chemical analysis on-chip are still weak points in many lab-on-a-chip devices. The current proposal, aiming the integration of 'all laboratory-based process steps' in one single step, is both challenging and feasible: development of a microfluidic chip that combines blood sample processing (DNA extraction/purification, multiplex amplification) and detection of EGFR mutations in tumour DNA by means of gold and silver-nanoparticles (Ag and Au-nanoprobes). Furthermore a microfluidic chip analyser with an integrated user-friendly software to report genotyping results will be developed.",Point-of-care blood device for fast and reliable prediction of drug response in non- small-cell lung carcinoma patients from blood samples,FP7,06 February 2015,07 February 2013,1056000.0 LUPAS,Linköping University * Linköpings Universitet,health,"In this project we seek to develop new smart imaging molecular tools for combating neurodegenerative diseases such as Alzheimer's disease and prion diseases. Emphasis is put on translational applied research for the development and validation of novel properly functionalized luminescent conjugated polymers (LCP) that via modern imaging technology can give rise to entirely new and innovative methodology for studying neurodegenerative diseases. The objectives include the development of novel imaging agents that can be utilized for biomedical research, diagnosis, monitoring and prognosis, and for support and guidance of therapeutic interventions for Alzheimer's disease and prion diseases. The consortium is composed of expert groups in experimental optics, polymer synthesis, magnetic resonance imaging (MRI), synthesis of functionalized magnetic nanoparticles, amyloid structure, AD mouse models, clinical AD, and prion diseases. At the same time this project establishes strategic links between mainly SME based Industries, expert researchers at universities and principal users in terms of hospitals. The project consortium will develop and share an efficient plan for dissemination and exploitation of the project results.",Luminescent polymers for in vivo imaging of amyloid signatures,FP7,31 December 2012,01 November 2009,4978094.0 LYMPHIMMUNE,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"Tumors often engage the lymphatic system to invade and metastasize. The tumor-draining lymph node (dLN) may be an immune privileged site that protects the tumor from host immunity, and lymph flow draining tumors is often increased, enhancing communication between the tumor and the sentinel node. In addition to increasing transport of tumor antigens and regulatory cytokines to the lymph node, increased lymph flow in the tumor margin causes mechanical stress-induced changes in stromal cells that stiffen the matrix and alter the immune microenvironment of the tumor. In this proposed project, we will investigate the interplay between lymphatic drainage and flow-induced mechanotransduction in the tumor stroma that may synergize to promote tumor immune escape by appropriating lymphatic mechanisms of peripheral tolerance. We will address the hypothesis that lymphatic drainage and flow-induced mechanotransduction in the tumor stroma synergistically promote tumor immune escape by altering the immune microenvironment, and that targeting lymphatic drainage from the tumor may represent a new avenue for tumor immunotherapy. For the latter, we will develop strategies to limit or block lymphatic flow in the tumor microenvironment and characterize their ability to improve the efficacy of tumor immunotherapy by dampening local immunosuppression in the tumor stroma and tumor-draining lymph node (dLN). We will combine in vivo mouse models and intravital imaging with engineered in vitro microenvironments and nanoparticle-based targeting strategies in three broad aims designed to constitute several PhD and postdoctoral projects.",Flow in the tumor microenvironment: Linking mechanobiology with immunology,FP7,30 April 2018,01 May 2013,2499636.0 M&M'S+,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"Additive manufacturing technologies such as 3D printing of polymers and metals have a large impact in many sectors. In this project we propose to explore ways to develop and commercially exploit a new type of 3D printing tool for manufacturing of silicon nanostructures. These 3D printers will make it possible to design and implement silicon micro- and nano-electromechanical system (MEMS&NEMS) sensors and photonic components in low volumes at affordable costs. As a result, resource-intensive semiconductor clean-room infrastructure will no longer be required to design and implement MEMS, NEMS and photonics components. A 3D printer for silicon nanostructures is made possible by employing a novel additive layer-by-layer manufacturing process that has been developed within the ERC Starting Grant project M&M´s (No.277879) lead by the PI. This process is based on alternating steps of chemical vapour deposition (CVD) of silicon and local implantation of gallium ions by focused ion beam (FIB) writing. In a final step, the defined 3D structures are formed by etching the silicon in potassium hydroxide (KOH), where the ion implantation provides the etching selectivity. The feasibility of the technology has been demonstrated within the ERC-M&M´s project by forming 3D silicon structures with layer thicknesses of 40 nm and lateral dimensions as small as 30 nm. To implement a 3D printer that can manufacture 3D silicon nanostructures from computer-generated 3D graphics, the steps of focused ion beam (FIB) writing and silicon deposition have to be combined as a fully automated switched process in a single tool.",3D Printer for Silicon MEMS & NEMS,FP7,31 March 2014,01 April 2013,149947.0 M&M´S,Royal Institute of Technology * Kungliga Tekniska Högskolan,information and communications technology,"Micro- and nanoelectromechanical system (MEMS and NEMS) components are vital for many industrial and consumer products such as airbag systems in cars and motion controls in mobile phones, and many of these MEMS and NEMS enabled applications have a large impact on European industry and society. However, the potential of MEMS and NEMS is being critically hampered by their dependence on integrated circuit (IC) manufacturing technologies. Most micro- and nano-manufacturing methods have been developed by the IC industry and are characterized by highly standardized manufacturing processes that are adapted for extremely large production volumes of more than 10.000 wafers per month. In contrast, the vast majority of MEMS and NEMS applications only demands production volumes of less than 100 wafers per month in combination with different non-standardized manufacturing and integration processes for each product. If a much wider variety of diverse and even low-volume MEMS and NEMS products shall be exploited, the semiconductor manufacturing paradigm has to be broken. In this project, we therefore will focus on frontier research on new paradigms for flexible and cost-efficient manufacturing and integration of MEMS and NEMS within three related research areas:",New Paradigms for MEMS & NEMS Integration,FP7,10 July 2018,11 January 2011,0.0 M-RECT,Victrex plc,construction,"The M-RECT project aims to create multiscale-reinforced semi-crystalline thermoplastics (PEEK and PPS), which will outperform all reinforced polymers in terms of strength, stiffness, creep and mainly damping by upscaling and further developing state of the art production methods, within cost-efficient manufacturing routes. The envisaged multiscale reinforcement will comprise of dispersed straightened and aligned to polymer molecules multi-walled carbon nanotubes (CNTs) and also fully impregnated, long carbon fibres (CF). In order to achieve this objective a number of novel technological achievements including CNT functionalization techniques, fluid-assisted CNT alignment, microwave and induction heating of composites, out of autoclave manufacturing including bagging techniques, DIRIS sandwich panel production, fluoropolymer radiation-absorbing coatings and polymer optical fibre technology will be further developed and used. The CNT or multi-scale reinforced PEEK or PPS sheets and the resulting sandwich panels will be used as raw material for manufacturing laminated complex prototypes covering a wide range of industrial applications such as automotive, railroad, aeronautical, space, civil engineering and biomedical. Optimized design of these structures will be based on suitably developed numerical modelling and optimization tools within the proposed project and which will be validated through extensive testing at nano, meso and macro-scale. The anticipated impacts of the development of the envisaged top-performance lightweight thermoplastic composites and their manufacturing routes will extend to an international level by decreasing energy and fuel consumption, decreasing waste production and improving recyclability, creating profitable spin-off activities, promoting safety and improving the urban environment.",Multiscale reinforcement of semi-crystalline thermoplastic sheets and honeycombs,FP7,04 February 2015,04 March 2011,4734829.0 M6,University of Applied Sciences Kaiserslautern * Fachhochschule Kaiserslautern,health,"For some decades the world has been able to see the ultimate impact of device miniaturisation which has led to dramatic growth in national and global revenues alongside the huge benefits that have been brought to human activities, in the healthcare/medical, energy, space, transport, communication and defence sectors. Evolving initially from silicon based manufacturing technologies thanks to the huge investment and established infrastructure, current state-of-the-art play in moving further according to the 'More than Moore' has substantially extended the global capacity in achieving complex microsystem integration using hybrid processes, multi-materials that are significantly confined in an ever small space or dimensions. The challenges in the endeavour of continuous miniaturisation therefore exist in the fundamental understanding of the phonemes behind all the play, in order to underpin a paradigm of future generation miniaturised device. With significant developments for some decades the various capabilities and expertise bridging the EU and Asia are now available to readily forge a tangible strong consortium targeting such an important field. Given its inter-disciplinary nature, the project will cover a wide breadth of research topics as demanded through collaborations and researchers' mobility provided by International Research Staff Exchange Scheme as one of the Marie Curie Actions to draw the strength from the representative institutions in Germany, Japan, China and UK. The project will focus on the potential challenges and potential issues encountered in the integration of miniaturised devices in terms of novel materials and processes, characterisation and testing, demonstrating the manufacturability and reliability. Both experimental and computational approaches will be applied to elaborate the fundamental aspects of multi-material behaviour at micro- and nano-scales.",Micro- Multi-Material Manufacture to Enable Multifunctional Miniaturised Devices,FP7,30 June 2015,01 July 2011,529200.0 MACALO,Norwegian University of Science and Technology * Norges Teknisk-Naturvitenskapelige Universitet (NTNU),information and communications technology,"MACALO has two main deliverables, one in software and one in hardware which form the core business of the two European high-tech companies in the consortium. The MACALO consortium consists of pioneers of MAgnetoCALOritronics who cover the complete chain from SME start-up company innovation in hardware and software, device simulation and fabrication, benchmark measurements, computational materials science, and basic science, who are committed to employ their expertise to realize the main objectives. The primary goals of MACALO are",Magneto Caloritronics,FP7,08 July 2015,09 January 2010,0.0 MACHERENA,Mecanizados Escribano SL,transport,"The main objective of the project is the improvement of tools for the machining of heat resistant aeronautic materials. This improvement will translate into larger tool life, better finishing quality of the part or process speed up. This will involve a significant reduction of the machining costs of these materials, and thus the manufacturing costs of the aeronautical parts. The following processes will be evaluated: drilling, milling and turning. The materials that will be tested are: Ni- Fe alloys, Ni alloys and TiAl intermetallic. The project aims at improving the tools by means of: -redesign of the tools -development and applications of superhard and high toughness nanocomposite coatings -development of advanced machining processes (high pressure cooling machining) The nanocomposite coatings will be optimized at laboratory level on samples with the assistance of its characterization (hardness, friction, wear, adhesion, etc) and surface analysis. The optimised treatments will be applied on the selected tools. The tools performance will be tested both at laboratory level and in industrial conditions: life, failure mode or cooling required will be some parameters that will be tested. Additionally, the failure mechanism of the tested tools will be evaluated, so the optimisation of the tools can be properly oriented. Finally, the tools will be used in the manufacturing of demonstrators, so the developed processes are validated in real working conditions. The results of this project will lead to a decrease in the manufacturing cost of difficult to machine materials, which will increase competitiveness of aeronautical industry. Furthermore, in the case of Ni alloys or TiAl intermetallic a reduction of these costs will allow the inclusion of a higher number of parts manufactured with these materials in aero engines. In the long term this will result in the production of smaller engines, with improved fuel efficiency, reduced #",New tools and processes for improving machining of heat resistant alloys used in aerospace applications (MACHERENA),FP6,30 June 2007,01 January 2004,2310392.0 MACNEMS,ICN2 - Institut Català de Nanociència i Nanotecnologia,information and communications technology,"Nanoelectromechanical systems (NEMS) are very promising for sensing purposes, information technology, or exploration of quantum mechanics in extended bodies. A decisive parameter for any oscillator is the quality factor, Q, determining how much energy the system dissipates during one oscillation period. A high Q signifies large oscillator amplitudes and a sharp resonance. Although NEMS resonators display quality factors up to 10^6, their amplitudes are typically in the pm range or below, which makes the conversion into a readable electrical signal extremely challenging.",Mechanical Amplification in Carbon-based NanoElectroMechanical Systems,FP7,02 April 2015,03 January 2011,0.0 MACOMUFI,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"R&D and investment in electronics overwhelmingly focus on multifunctionality, which should meet the market demands for radically new components that are more compact, cheaper, and consume less power. Particular attention is being devoted to MagnetoElectric (ME) multiferroics exhibiting simultaneous FerroMagnetic and FerroElectric properties, both being coupled. Such materials allow reversing the magnetization by an electric field and vice-versa. ME materials can thusly provide optimum solutions to many device-design problems, with a high potential impact on important segments of the electronics market: high-density electric-field controlled MRAM, HF wireless telecoms, spintronics? However the physics of ME coupling is far from being understood. This limits knowledge-based research for materials with optimised properties, and ultimately prohibits industrial use of ME thin films. The objective of the present STREP proposal MaCoMuFi is to ?MAnipulate the COupling in MUltiferroic thin FIlms (made of single phase, multilayers and nanocomposite materials) to ultimately accelerate the development of novel devices for the European Industry. It will set up the first systematic knowledge-based approach in the domain, involving the tight collaboration between oxide synthesis, complex oxides modelling and device design experts. The main expected outputs of the project are (i) novel oxide thin films (5nm thick) with significant ME coupling (higher than 1V/cm.Oe) at room temperature, (ii) performance validation in new electronic devices (spin filter, magnetic memory, agile filter?), (iii) understanding the relationship between process, structure and composition of the multiferroic oxide thin films, (iv) optimised production processes and tailoring methods, (v) new techniques for ME coupling measurement and nanostructural characterisation and (vi) a software tool for the design of ceramic thin films with optimum ME properties.",Manipulating the Coupling in Multiferroic thin Films,FP6,31 December 2009,01 September 2006,2400000.0 MACONS,University of Cambridge,photonics,"The commercial market for electronic and optoelectronic devices based on nitride semiconductors is growing extremely fast, but the fundamental science underlying these devices is lagging behind. This proposal aims to explore the vital link between structure and properties in nitride materials, in order to reveal the limitations of current devices and to pave the way for new, improved technology. The key strategy of the proposal is to combine multiple microscopy techniques to develop a comprehensive understanding of nanostructures and defects in the nitrides, and to link these discoveries to nanoscale measurements of the optical and electrical properties. This will require a synergy of different techniques, from techniques commonly used on metals (such as atom-probe tomography) to techniques which focus exclusively on semiconductors (such as scanning capacitance microscopy). It will also require the development of new approaches to the application of these techniques, to allow the same nanoscale regions of material to be assessed in multiple microscopes, so that the structure and composition of a specific nanostructure may be linked directly and unambiguously to its electrical and optical properties. Overall, the aim is to provide a much more complete picture of nitride materials science than has ever previously been achieved, and to apply this new understanding to engineering improved materials for nitride optoelectronic devices.",A multi-microscopy approach to the characterisation of Nitride semiconductors (MACONS),FP7,30 November 2016,01 December 2011,1371893.0 MACRO-CLEAN,University of Brighton,environment,"The management of contaminated groundwater, surface waters and drinking water is a major issue both in the EU and globally, where recent (and historical) industrial, urban and commercial activities have led to the presence of elevated concentrations of a wide range of contaminants in surface- and ground-waters, adversely affecting the health of millions of people. This has been recognised in a number of recent directives (e.g. the Water Framework Directive, the Groundwater Directive) aimed at protecting ground and surface water resources within the EU. However, despite much progress, groundwater and surface water quality is still highly variable across Europe, and there is an urgent need to develop and fully implement forward-looking technologies to clean-up water and keep it free from pollution. In this project we intend to combine innovative biomaterial / gel technologies with nanotechnologies to develop and commercialize innovative products for the remediation or clean-up of contaminated ground and surface waters. A range of permeable composite gels in which nanoparticles will be embedded will be produced and tested for application as water clean-up devices. Achieving the objectives of the project will benefit to all European citizens, economy, agriculture and industry and will place Europe in a leading position in the area of polymer-based remediation devices and technologies. This is an inter- and multidisciplinary proposal, which will offer a top class young researcher great opportunities to develop her existing skills, acquire new skills in the area of materials, environmental science and nanotechnology and, more specifically, in the area of technologies for remediation and clean-up devices, generate new knowledge and obtain training in transferable skills and thus develop a successful career as an independent researcher in the field of environmental science and materials for remediation.",Macroclean - developing novel gel-based technologies for water clean-up,FP7,04 May 2012,04 June 2010,171091.96 MACRO-MSAA,University of Cambridge,health,"Project Summary and Research Objectives: Dictyostatin is a potent inhibitor of cell proliferation at the nanomolar level, causing cell cycle arrest at the G2/M phase and inducing apoptosis. By sharing the same microtubule-stabilising mechanism as the anticancer drug Taxol, and retaining activity against Taxol-resistant cancer cells, the marine macrolide dictyostatin is a potential new chemotherapeutic agent for the treatment of solid tumours. Due to the extremely low isolation yield from the natural sponge source, total synthesis is essential for generating useful quantities of dictyostatin and determining the full structure. The main objective is to develop a flexible and modular synthesis of the 22-membered macrolide dictyostatin, using methodology developed in the host group, enabling the determination of the configuration at the 11 stereogenic centres and providing material for further biological evaluation. A secondary objective is the synthesis of novel macrolide analogues and hybrid structures, which would be tested for tubulin bundling and cytotoxicity. Expected Benefits: The researcher will benefit by improving her research training and by expanding her knowledge and experience in the synthesis of biologically active molecules that may have therapeutic potential, a field that she wishes to pursue after postdoctoral work. Not only will there be opportunities to learn and develop new synthetic methodologies, but also to participate in multidisciplinary research at the interface of chemistry, biology and medicine. The Chemistry Department of Cambridge University is a world renowned institution and the scientist in charge has exceptional experience in the total synthesis of biologically important compounds, particularly anticancer agents, and the development of new synthetic methods, and has extensive international collaborations.",Synthesis of Marine Macrolides and Hybrid Structures as Novel Microtubule Stabilising Anticancer Agents,FP6,30 November 2005,01 December 2003,162448.0 MACROMOLECULESATWORK,University of Barcelona * Universitat de Barcelona,health,"The objective of this proposal is to combine different computational methods to study the physics of specific cellular components and processes which involve biological macromolecules. We will especially concentrate on the study of polyelectrolye DNA chains and analogous biopolymers and will investigate on their interaction with cellular structures and on the mechanisms of modifications of their physical properties. The understanding gained will allow us to explore different cellular processes related to gene delivery such as self-assembly of cationic lipid-DNA complexes and membrane fusion, relevant because of their fundamental properties as well as their applications in the biomedical sector. To achieve this goal, it is necessary to reach time and length scales in which macromolecules evolve, a regime that is out of reach of standard modelling approaches. To this end, we intend to adopt and refine a new chemically-aware coarse grained scheme and use complementary state of the art modelling techniques such as atomistic molecular dynamics and unspecific coarse graining. In addition, supercomputing techniques and resources will be exploited to provide unique scientific insights. The proposal will benefit from the expertise in biomolecular studies of scientists at the Barcelona Biomedical Park (PRBB), which will guarantee feedback and a cross-field perspective to the management of the project and to the production and interpretation of scientific results. This project is very relevant to the goals of the IEF activity of the people work programme because of its ingrained multidisciplinary character and because it directly targets key research areas indicated by the EU such as biotechnology and nanotechnology. The different training and research activities planned would increase and diversify the scientific competences of the fellow, leading him to a more independent and mature professional status on which to build his future career.",Unveiling the physics of cellular processes: new approaches to study macromolecules at work,FP7,30 September 2010,01 October 2008,150802.0 MAFIN,University of Konstanz * Universität Konstanz,manufacturing,"Mass data storage on magnetic hard drives in portable products is a new and fast growing market with an estimated turnover of several billion EUR per year. However, continued growth of storage density is limited as a result of the thermal instability of recorded data. To overcome this so called 'superparamagnetic effect', the use of discrete media, in which information is stored in single nanostructures, will become mandatory. However, the relevant roadmaps indicate that the required lithography tools will not be able to provide the needed feature size, performance and cost efficiency in time. Therefore it is likely that magnetic recording media will be the first technology which requires the introduction of nanostructuring by self-assembly processes. MAFIN aims at developing a new magnetic recording media at prove-of-concept level for ultrahigh density magnetic storage applications, by using low-cost, environmentally friendly processes and both advanced and new nanotechnologies. MAFIN will provide the required breakthroughs for an innovative concept of magnetic media: based upon assisted self-assembly to produce a periodic array of nanoparticles expandable to wafer size scale, and further, the controlled sputter-deposition of magnetic films with high magnetic anisotropy deposited onto the nanospheres. Furthermore, by tilting the deposition direction with respect to the substrate normal 'tilted media' can be realized, a novel concept providing the writability of the recording media. All progress in these innovative concepts will be constantly monitored by various techniques, and will be underpinned by micromagnetic modelling. In addition, the recording performance will be investigated and screened by state-of-the art write/read testing and probe recording. The new knowledge gained will be protected by appropriate IPR and will strengthen the European position in many competitive and strategic fields, in particular, in data storage.",Magnetic Films on Nanospheres: Innovative Concept for Storage Media,FP6,31 May 2009,31 May 2006,1295000.0 MAG(NET)ICFUN,University of Regensburg * Universität Regensburg,health,"Functionalized magnetic nanoparticles are proposed as smart platforms for applications in chemistry - emphasizing catalysis -, environmental chemistry - emphasizing catalytic detoxification, or biomedicine - emphasizing delivery of biomolecules and drugs. The magnetic properties of the entities offer an additional dimension for their manipulation by external magnetic fields, e.g. for flow reactors, for recovery from the environment, for imaging (MRI) or for directed targeting of tumors in living beings. The consortium spans the synthesis of coated (graphene, silica, polymers) magnetic nanoparticles with metal and metal oxides cores, covalent and non-covalent functionalization with chemical and biomedical agents, applications in homogeneous and heterogeneous catalysis for fine chemical production or detoxification of the environment, or biomedical applications such as tumor recognition, drug delivery or gene transfection. Disciplines involved are Chemistry, Biochemistry and Bioanalytical Chemistry, Chemical Engineering and Material Science, Physics, and Medicine.",Functionalized Magnetic Nanoparticles and their Application in Chemistry and Biomedicine,FP7,30 September 2016,01 October 2012,4425987.0 MAGBIOMAT,Paris Diderot University * Université Paris Diderot - Paris 7,health,"The aim of the proposed project is to synthesize and characterize new nanostructured magneto-responsive biopolymer-based materials by the introduction of functionalized magnetic nanoparticles in biogel and foam to gain a deeper understanding of two fundamental aspects: - The understanding of the formation mechanisms of such structures: magneto-responsive networks. - The correlation between the behaviour of the nanostructured composite biopolymer-based materials under the change of external conditions, such as magnetic field, shear, ionic strength, pH and composition of polymer and magnetic nanoparticles or the chemical structure of the constituents. The research project will involve different aspects. On one hand, it will include the elaboration of new magnetic-responsive biopolymer-based materials. On the other hand, the project will try to develop specific dedicated apparatus, allowing the measurements of mechanical properties under magnetic field to determine structure and dynamical properties at different external conditions as well as kinetics of structure transformation of such systems controlled by magnetic field. The combination of synthesis, characterization and theory will allow a synergy for the elaboration and optimization of novel magnetic-responsive biopolymer based materials with fine tuned properties and for their future application in industry (vehicle for drug delivery, intelligent materials for medical and structural applications).",Study of magnetic responsive biopolymer based materials,FP7,30 September 2011,01 October 2009,165444.0 MAGBIOVIN,Vinca Nuclear Institute * Institut za Nuklearne Nauke Vinča,health,"Through the realization of MagBioVin project, the Institute of Nuclear Sciences 'Vinca', University of Belgrade (Serbia) receives important community support to upgrade its capacities related to the highly specialized research on activated magnetic nanoparticles (MNP) and radionuclide labeled magnetic nanoparticles for application in biosciences, pharmacy and medicine. This is planned to be realized by a set of comprehensive actions, such as engagement of eminent expert in the field (ERA Chair holder), bringing experimental facilities up to the most advanced EU-competitive level, cutting-edge trainings in reputable EU research institutions and intensive dissemination towards ERA, Universities and stakeholders. The Project foresees the key role of ERA Chair holder in improvement of organizational structure, research excellence and especially in communication with stakeholders. Organization of seven dedicated international workshops led by EU experts in the field, six extensive training programs for MagBioVin team members and the accent on intensified international collaboration, are few of the activities anticipated through Project implementation. These are designed to set solid foundations for a final goal: to rise both human and experimental capacities of the 'Vinca' Institute to the level that ensures considerable scientific and technological impact within ERA and its ability to compete with leading EU research institutions on an equal basis.",Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials,FP7,11 May 2019,12 May 2014,2243828.0 MAGDOT,Technical University Dresden * Technische Universität Dresden,manufacturing,"Spontaneous formation of nanostructures through kinetic and thermodynamic morphological instabilities at solid surfaces is increasingly recongnized as an attractive, low-cost alternative to top-down schemes for nanopatterning. We propose an integrated approach to examine the self-assembly of magnetic nano dots by spanning the atomistic to the continuum scales. The work will involve ab initio calculations, as well as statictical mechanics, mesoscopic and continuum calculations of the evolution of nanostructural morphology, composition , and self-assembly during deposition and annealing. By parameter passing, each effort will feed into the other, as the information at the smaller scales will be employed at the larger scales scale caculations, enabling us to bridge a wide range of length and time scales. The ultimate goal of the project is to develop an understanding of the important materials issue governing nanoscale self-assmbly, and to develop models that enable the first-principle design of novel super-high density magnetic storage materials. The understanding of the fundamental phenomena accompanying dot formation gained through computational approaches and experimental validation will facilitate the development of processing methods that yield regular arrays of magnetic nano dots for the next generation of magnetic storage materials.",Bridging Atomistic to Continuum - Multiscale Investigation of Self-Assembling Magnetic Dots during Epitaxil Growth,FP6,31 December 2009,01 January 2006,800000.0 MAGFORCE4AXONGROWTH,University College Dublin,health,"The lack of axon regeneration following spinal cord injury (SCI) diminishes patients' quality of life and poses a significant economic burden on the society. This project aims to investigate the complex axon guidance mechanism following a SCI scenario by applying mechanical tension on the growth cones (GCs) of central nervous system (CNS) axons via novel magnetic nanoparticles that are functionalized with neuronal cell adhesion molecule. It is hypothesized that the complex interaction of chemical and physical guidance cues at the cytoskeletal (CSK) level can be modulated by mechanically activating specific signalling pathways, e.g., RhoGTPases. To test this hypothesis, mechanical tension will be applied to multiple GCs simultaneously, using a magnetic tweezers system integrated with a microfluidic culture device, which grants exclusive access to axonal areas. The effect of tension on axon outgrowth will be characterized as a function of chemical and mechanical environment, while examining the roles of Rho GTPase signalling and CSK structure in this mechanotransduction process. In essence, this project poses a biological hypothesis that can only be tested using a combination of sophisticated engineering methods. The results of this multidisciplinary project will provide a better understanding of axon elongation mechanisms and potentially become a promising therapeutic approach for SCI. The fellow is a mechanical / biomedical engineer with experience in microfluidic neuron culture and live cell microscopy; whereas the host is a world leader in single molecule biophysics. This project will not only contribute to the scientific competency of Europe by tackling a very relevant medical problem, but also provide the fellow an excellent opportunity to gain high quality scientific training and complementary skills, necessary to obtain an independent researcher position in the European Research Area.",Application of Mechanical Forces on Axon Growth Cones via Magnetic Nanoparticles to Enhance Axon Regeneration in Central Nervous System,FP7,04 September 2013,05 September 2011,194810.0 MAGIC,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),manufacturing,"In the CMOS manufacturing environment, the mask-based optical lithography technique is up to now the driving solution to deal with all industry concerns. Nevertheless, this solution becomes less effective for each new technology node. Effectively, it requires more and more complex and expensive masks due to the introduction of optical proximity correction and phase shift techniques. The blow up of the tool price plays also an important role in the overall cost of ownership of this technique. This trend opens opportunities for the Mask-Less Lithography (ML2) technology, based on multi-beam principles and developed by the two European companies MAPPER and IMS Nanofabrication AG. The cost effective model of the ML2 option in association with the high resolution capability of the electron lithography and a reasonable throughput target represents an attractive alternative for lithography and is supported by some key CMOS manufacturers around the world, like TSMC, STMicroelectronics, QIMONDA, TOSHIBA, and Texas Instruments…_x000d_",MAsk less lithoGraphy for IC manufacturing (MAGIC),FP7,12 July 2012,01 January 2008,0.0 MAGISTER,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. . . Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but nowadays there is no way to grant that tissue regeneration take place in the pathological site. The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests [Ref. Nanomedicine roadmap]. The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds -magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. The magnetic moment of the scaffolds enables them with a fascinating possibility of being continuously controlled and reloaded from external supervising center with all needed scaffold materials and various active factors (AF). Such a magnetic scaffold can be imagined as a fixed 'station' that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the patient.",Magnetic Scaffolds for in vivo Tissue Engineering,FP7,30 November 2012,01 December 2008,8278091.0 MAGLOG,Bielefeld University * Universität Bielefeld,information and communications technology,"The integration of computers into every day life requires smaller, more powerful but less power consuming processing units. According to the ITRS roadmap, devices based on Si-only technology will face serious obstacles hindering downscaling and power reduction within a few years. Parallel data processing, faster interactions between logic functions and memories, and reconfigurable logic functions are needed in particular for applications that require image processing. In magnetic logic the direction of the magnetisation in sub-micron patterned ferromagnets is identified with Boolean logic 1 or 0. The input changes the magnetisation of one structure and the output - i.e. the logic function - is then defined by the layout and the magnetisation states of the subsequent structures. As first demonstrated by the partners UDUR and UOB, Magnetic Logic promises low power non-volatile computing, 'on the fly' re-programmability, massively parallel character and ultrafast operation and thus has the potential to become a key technology for logic circuits. Magnetic Logic could also bring together real time reconfiguration and universal memory - key success factors compared to other semiconductor techniques for reconfigurable logic. This FET-OPEN STREPS project will integrate key European research groups hi the field hitherto unrelated to each other. Three approaches to Magnetic Logic will be compared to establish the proof of concept of this new technology, keeping Europe at the forefront of magnetic logic. The consortium comprises the two leading European laboratories UOB and UDUR, reinforced by groups bringing alternative approaches (CEA - Hall effect), experimental and theoretical techniques (TUKL and UPS) and an industrial partner (ST) with the capacity for developing the required architecture and advanced CMOS technology. The largest of the four work packages jointly explores and drives forward the frontiers of magnetic logic by establishing full Boolean families and interco",Exploring the Frontiers of Magnetic Logic,FP6,29 February 2008,29 August 2004,1904653.0 MAGLOMAT,University of Duisburg-Essen * Universität Duisburg-Essen,information and communications technology,"The performance of today's microelectronics is increased by continuous miniaturization, however, the fundamental limits will soon be reached. An alternative approach to increase the computational power is to take advantage not only of the charge of the electron but of the spin as well. This field is nowadays known as 'Spintronics'. Recently it was demonstrated that the non-volatile magnetic random access memory (MRAM) can in principle serve as reconfigurable magnetologic gate. To employ these MRAM elements for logic operations, materials-related challenges remain to be solved. The goal of this project is to synthesize new heterogeneous materials by functional doping of oxide semiconductors to engineer ferromagnetic electrodes and tunnel barriers from only one type of material. Further, monodisperse ferromagnetic nanoparticles shall be incorporated in oxide semiconductors as well forming a magnetically doped oxide-semiconductor where the size and distribution of the magnetic particles is more controllable compared to clustering in highly doped semiconductors. Such granular magnetic semiconductors (GMS) will enable to study the magnetic interaction of magnetic impurities through the semiconductor host under well-defined conditions. These two types of nano-engineered materials shall be integrated into all-oxide spin-valve structures as a building block for novel reconfigurable magnetologic devices with nanoscale dimensions. Prototypes of such devices, which are expected to offer dramatically increased functionality compared to transistor logic, shall be fabricated and tested.",Nano-engineered magnetic materials for spintronics and magnetologic applications,FP6,31 May 2009,01 June 2005,1336843.0 MAGMANET,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),information and communications technology,"MAGMANet is an interdisciplinary NE that focuses on the magnetic properties of molecular based systems. This emerging research field requires Europe to integrate the necessary critical mass of resources and facilities to retain its world leadership. MAGMANet is committed to attain this goal by addressing the following main objectives: 1. Tackle the fragmentation of European research in molecular magnetism and increase its cost effectiveness 2. Provide lasting integration of research and technological developments in this field by the creation of the European Institute of Molecular Magnetism (EIMM) 3. Deliver world class resources through developing a Virtual Laboratory of excellence and selected Technological Platforms 4. Strengthen the leading role of European research in the field by expanding interdisciplinary cooperation 5. Promote education, public citizen awareness and knowledge dissemination in this emerging research field 6. Stimulate industrial innovation and technology transfer The consortium comprises 15 leading European players in the field from 8 EU states plus Romania and Switzerland. The entire range of expertise necessary for carrying out research in molecular magnetism is involved from theoretical and solid state physics to synthetic organic and inorganic chemistry. Lasting integration and long term existence of the EIMM depends on the quality of the integration and of the research work carried out, and on durable funding. MAGMANet will develop a financing scheme that will rely on considerable industrial involvement (from multinationals to SMEs) by creating an Industrial Support Group. The NE will provide the impetus to move from collaboration to actual integration leading to the creation of the EIMM. The NE will generate the knowledge and technology of tomorrow in: information science (nanoscale data storage, quantum computing), healthcare/biomedicine (magneto-optical switches, biocompatible magnets), safety and security devices.",Molecular Approach to Nanomagnets and Multifunctional Materials,FP6,31 October 2009,01 May 2005,1.047E7 MAGNANOVES,University of Manchester,health,"This project will develop a new 'smart' self-assembled biomaterial containing supramolecular magnetic nanoparticle-vesicle assemblies (MNPVs) as the active elements, which are able to convert non-invasive magnetic signals into biochemical responses in cells. This new biomaterial will have enhanced biocompatibility and allow spatiotemporal control over the release of bioactive compounds from MNPVs in the hydrogel. To achieve temporal control, a dual-release mechanism will be built into the biomaterial so that a short duration magnetic pulse will release a bioactive compound and elicit a cellular response, followed by a longer duration 'self-destruct' magnetic pulse that will release enzyme/reagents able to dissociate the MNPVs and the surrounding hydrogel. Both non-covalent and enzymatically cleavable linkages between magnetic nanoparticles and vesicles and in the hydrogel matrices will be assayed. This second 'self-destruct' signal will facilitate non-invasive clearance of the synthetic hydrogel either in vivo or in vitro without mechanical damage to the cells. To achieve spatial control, the hydrogel will be magnetically patterned at the macro and micro scale during the preparation of the vesicle gels. Furthermore, to increase the hospitability of the prepared biomaterials across cell types and target the MNPVs to certain cell lines, glycolipids and lipopeptides will be synthesized chemically/chemoenzymatically and doped into MNPVs. Throughout the project, each magnetically responsive biomaterial will be tested as a cell culture platform, with the effect of the released compounds on the cells assessed using standard assays, like cell counting, MTT for metabolic activity, DNA assays for cell proliferation, flow cytometry and real time PCR. Obtaining spatiotemporal control over cells cultured in these 'smart' self-assembled biomaterials will open a path towards exciting potential applications in tissue engineering and regenerative medicine.",Magnetically responsive nanoparticle-vesicle hydrogels as 'smart' biomaterials for the spatiotemporal control of cellular responses,FP7,30 April 2015,01 May 2013,221606.0 MAGNETIC_PCR,Progress and Health Foundation * Fundación Pública Andaluza Progreso y Salud,health,"The Magnetic-PCR project propose a brand-new and ultrasensitive methodology for detection and classification of breast cancer subtypes based on detection of specific genes expression. For this, the project develops a new 'magnetic relaxation switch' (MRSw) biosensor based on superparamagnetic nanoparticles to improve the sensitivity of the Polymerase Chain Reaction (PCR) for detecting nucleic acids. Relaxometry and Magnetic Resonance Imaging (MRI) will be used to sensing DNA or RNA biomolecules. The ultimate goal is to achive direct application of a MRSw sensor for detection and classification of breast cancer malignancy by magnetic resonance (MR).",Magnetic-PCR: An ultrasensitive methodology for Breast cancer detection and characterization.,FP7,28 February 2015,01 March 2013,230036.0 MAGNETOP,Free University of Berlin * Freie Universität Berlin,information and communications technology,"Electronic states that could propagate long distances without power dissipation and with spin coherence (i.e. without losing information about their spin state) would be desirable for the design of energy efficient electronic devices and to make reality theoretical proposals of quantum computation devices. Topological insulators are recently discovered materials that may potentially offer these foreseeable properties. These materials are insulating in bulk, but present metallic edge states that are naturally preserved from backscattering by time reversal symmetry. In other words, the propagation direction and the spin state are correlated in these systems, so in order to be scattered, electrons must flip their spin (break time reversal symmetry). Experimental results already indicate the existence of such states but still a huge experimental effort is necessary to reach the necessary understanding and the technical skills to take advantage of the predicted surprising properties of these materials. Specially promising are the expected consequences of the application of a local magnetic field to these topologically protected states. Between other consequences, this would allow the confinement and manipulation of these states and would be therefore a first step towards the fabrication of theoretically proposed devices based in the special properties of these materials. We propose here a comprehensive study of the effect of magnetic field in different topological systems (HgTe quantum wells and the so called 3D topological insulators) by means of state of the art nanofabrication and characterization techniques, including an innovative combination of scanning probe microscopies and electronic transport measurements. Our aim is to provide a complete (local and non-local) picture of the electronic transport and electronic structure characteristics of these materials as well as to provide means to manipulate and confine their exotic topological states.",Probing the effect of Time Reversal Symmetry breaking by the application of a local magnetic field in topological insulators.,FP7,08 July 2017,05 January 2012,222920.0 MAGNETOTUBE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Magnetite nanotubes are interesting for numerous applications including MRI, Biological and molecular separation, arsenic removal and catalysis of ammonia synthesis. The goal of this project is thus to create magnetic peptidic nanotubes using a bottom-up approach. A self-assembled peptidic nanotube template will be used to nucleate or attach magnetite nanoparticles on its inner and / or outer surface. The peptides will be selected for their ability to self-assemble in water and potential to mineralize magnetite or silica on their surface. The magnetite nanoparticles (Fe3O4) will be formed by oxydation of Fe(II) precursors onto the peptide surface or extracted from magnetotactic bacteria and bound onto the tube surface. We will also mineralize an additional silica layer in order to create triple-layered nanotubes (magnetite-peptide-silica or peptide-magnetite-silica) to improve the resilience and biocompatibility of these nanotubes. If necessary, the peptidic part will be removed through heating at high temperature (600°C). The resulting objects will be studied using SAXS, TEM, optical microscopy, Mössbauer spectroscopy.This study will help to gain insight on the biomineralization mechanisms used by magnetotactic bacteria to control the precipitation of magnetite chains in their cytoplasm.",1D magnetic nanostructures using mineralizing peptides,FP7,29 February 2016,01 March 2014,168794.0 MAGNIFYCO,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The 'magnetic nanocontainers' we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment stimuli, the release of drug with high selectivity for ovarian carcinoma. These multifunctional tasks are made possible due to the inclusion of three main components: a) the magnetic nanoparticles, allowing detection by MRI, cancer treatment by hyperthermia and providing stimuli for drug release; b) the nanocontainers, which allow for drug encapsulation and protection from degradation, facilitate the release of the drug upon application of an external stimulus, such as heat, or an internal one, such as the acidic pH of the tumour cells; c) the antibody fragments attached to the surface of the magnetic nanocontainers to deliver them selectively to the ovarian cancer cells. The individual building blocks and their assemblies will be characterized with respect to physical, chemical, and biological features, followed by dissemination of the newly acquired knowledge. Cell culture experiments will allow to understand the performance of such nano-tools in vitro. Directed towards application in patients, in vivo animal studies will be carried out on the most successful magnetic nanocontainers. The objectives of this proposal cover a wide range of scientific fields, hence a truly interdisciplinary collaboration between chemists, physicists, and biologists is required. To this end, we propose a european network collaboration between academic partners, who will take care of the development of new solutions for nanofabrication, and industrial partners implied in the field of the proposed application who will evaluate/develop the materials and act as advisors for risks arising during the project.",MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE,FP7,28 February 2013,01 September 2009,3435956.0 MAGNONICS,University of Exeter,photonics,"The opportunity to modify spectrum of excitations in materials with periodically modulated properties has stimulated striving research activity in the area of artificial periodic structures with aim to design novel materials with new revolutionary functionalities - so called meta-materials. Photonic, plasmonic, and phononic crystals and semiconductor superlattices are typical examples of exploitation of this concept for controlling light, acoustic wave and electron propagation and scattering in electronic and opto-electronic devices. Magnetic materials with periodically modulated properties are also known to possess properties that cannot be reduced to those of constituent layers. The best example here is the phenomenon of giant magnetoresistance (GMR), discovery of which was marked by the Nobel Prize Award last year. Importantly, the spectrum of magnons in periodic magnetic materials has band structure. By analogy to other band-gap materials, periodic magnetic structures used as a medium for controlled propagation of magnons are called magnonic crystals, while the corresponding field of research is called magnonics. The objective of the proposed project is to bring together several European research teams with a broad of fabrication and characterization expertise in order to realize practically this new class of meta-materials -magnonic crystals. We will create 1D, 2D, and 3D magnonic crystals with dynamical magnetic properties tailored at the nano-scale. The created magnonic crystals will be then used to replace continuous magnetic materials within various devices ranging from electro-motors and actuators to nano-scale magnonic logic elements, in which magnons will be used as signal carriers. The experimental data obtained in the course of the project will be used to test existing and to create new theories of high-frequency magneto-dynamics in magnetic nano-structures.",Magnonics: Mastering Magnons in Magnetic Meta-Materials,FP7,14 September 2012,15 September 2009,3499820.0 MAGNONMAG,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),information and communications technology,"Our aim is to establish long lasting collaboration in the frames of a research program the goal of which is to develop novel methods of control and manipulation of the magnetic degree of freedom in nominally nonmagnetic materials, in view of their potential for nanotechnology and nanoscience. The principal objective of the MagNonMag project is to bring together leading research groups in the field of nanomagnetism and establish an interdisciplinary training ground for both early stage researchers and experienced researches, enhancing the information partnership between theoretical and experimental research groups working in physics, chemistry, material science, and nanotechnology. The project is focused on nanomagnetism – magnetism shown by some materials on a nanoscale even if magnetically inert in the bulk – a novel physical effect with a potential for the emerging spintronics technology. The MagNonMag project will study the possibility to control magnetism by various means such as introducing sp impurities and defects in nonmagnetic materials through ion bombardment, fluorination, and transmutation doping. The objects under investigation are IV group elements with the emphasis on graphite/graphene systems. Induced magnetism phenomena studied in this project have a potential to provide new effects and functionalities which are highly desirable and of great technological and economic relevance. The synergy of the scientific strength of the Russian Academy Institutes with the technological and analytical potential in the research groups in EU (Sweden, Spain, Italy) and Australia provides a valuable opportunity to study and understand novel phenomenon of induced nanomagnetism which is promising for nanotechnology applications.",Magnetic order induced in nonmagnetic solids,FP7,03 July 2018,04 January 2012,524700.0 MAGNOSTICS,Surflay Nanotec GmbH,health,"The project at hand aims at the development of new improved magnetic nano particles for diagnostics. These magnetic nano particles will then be incorporated in layer-by-layer capsules, which allow for a better detection of tiny amounts of analyte material in blood, urine and other body fluids. This innovative technology will significantly improve the reliability of the analysis of small amounts of bioorganic material and thereby facilitate medical diagnosis. If nowadays samples have to be sent to diagnostic laboratories for analysis, with the new technology every practitioner will be able to conduct diagnostic tests himself. Surflay, the Berlin-based host company for this project, is specialised in layer-by-layer technology and its application in diagnostics. However the necessary knowledge about the preparation of magnetic nanoparticles is missing. Therefore, Surflay plans to host Dr. Huang from Sichuan University, China for two years. Dr. Huang has achieved unique results on the preparation of magnetic nanoparticles. This project is meant to be the foundation of a long-term cooperation between Sichuan University and Surflay as well as other European network partner of Surflay.",Development of Magnetic LbL Particles for Diagnostics,FP7,16 October 2010,17 August 2009,170418.0 MAGNUS,Queen's University Belfast,energy,"The aim of this research is to create multifunctional lightweight composite aerostructures utilising the unique properties of recently-developed carbon nanotube webs (CNTWs), produced from directly spinnable CNT forests (highly aligned CNTs grown on a silicon substrate). These webs will be strategically introduced into laminated carbon-fibre material to mitigate the current limitations primarily associated with poor impact damage resistance and poor electrical conductivity for lightning strike protection. The piezoresistive properties of CNTWs will also be exploited for structural health monitoring of bonded joints and their thermal conductivity investigated for potential anti-icing applications. Remarkably the inclusion of CNTWs would add negligible weight to the overall composite structure but a number of challenges will need to be overcome for their effective utilisation. This research proposal details a body of work which will address these challenges. A successful outcome will deliver a disruptive technology in the design and construction of the next generation of composite aerostructures. It will yield a significant weight reduction in future airframes and potentially lower maintenance costs, which will contribute to the overall aims of the European Union to reduce the environmental impact of aviation. Some of the additional functionalities, arising from the use of CNTWs, will also be of interest to other transport sectors and the wind energy industry.",MULTIFUNCTIONAL COMPOSITE AEROSTRUCTURES UTILISING CARBON NANOTUBE WEBS,FP7,28 February 2018,01 March 2014,100000.0 MAGPRO²LIFE,Solae Denmark A/S,health,"Biotechnologically derived substances for large scale feed, food and pharma applications represent one of the most important sources of new products due to their precisely controlled structural and functional properties, potential for economic and responsible production and overall broad benefits to society through biocompatibility and sustainability. The costs of producing biomaterials are in many cases dominated by separation processes, which can constitute 80% of the total cost of production. Using smart magnetic adsorbent particles to selectively separate the target product out of a complex product mixture like the fermentation broth or bio-feed stock can drastically reduce costs. By using magnetic separation and extraction technologies to separate the magnetic carrier particles, novel processing ways emerge. The main objective of the MagPro²Life project is to scale-up innovative nanotechnology based processes defined in the previous NanoBioMag Project, funded by the EU under the FP6 programme (NMP3-CT-2005-013469), to pilot-line-scale and demonstrate those for bio, food and pharma applications. Link to market needs is represented by a preliminary product selection of natural soy based nutraceuticals or pharmaceuticals like Bowman-Birk Inhibitor (BBI), a proteases inhibitor for MS-treatment, and Lunasin which is in discussion to have anti-carcinogenic properties as well as recombinant proteins and nucleic acids (Fragment-Antibody-Binding and Phytase). The Consortium is driven by the potential the magnetic separation technology has for improving the value-chain in industrial production for emerging biotech, food and pharma markets.",Advanced Magnetic nanoparticles deliver smart Processes and Products for Life,FP7,30 June 2013,01 July 2009,7399827.0 MAGRSA,University of Geneva * Université de Genève,health,"Methicillin-resistant Staphylococcus aureus (MRSA), a virulent organism resistant to many drugs, is responsible for most nosocomial and community-acquired infections. It can cause life-threatening disease, and treatment options are limited. Effective and rapid diagnostics is a strategic key element in the campaign against the spread of MRSA, allowing infection surveillance and control measures as well as more efficient patient treatment, and overall decreased health cost. The MagRSA project aims at the development of a new diagnostics platform that will provide a fast, simple and accurate identification of MRSA from clinical samples. The diagnostic protocol relies on a new and clinically validated procedure that consists in a direct one-step enrichment of MRSA present in either nasal, inguinal or wound swabs, followed by DNA extraction of immunocaptured bacteria and their identification by multiplex sequences amplification using quantitative PCR. This protocol will be implemented with a simple 'hand-off¿ system based on: (1) advanced microfluidic magnetic nanoparticles manipulation technology allowing efficient capture and extraction of target bacteria and nucleic acids, and (2) novel strategies for the integration of full operations required for the entire nucleic acid analysis chain in a microfluidic platform. Steps as sample preparation signal amplification by multiplex PCR and detection of multiple genes simultaneously will be integrated and automated in single fluidic chip. MagRSA project will bring together high-tech SMEs and advanced hospital/academic laboratories that are mutually independent leaders in their fields with complementary competencies. The ultimate objective is to reach a pre-clinical validation of the proposed diagnostic tool that not only addresses the unmet need in MRSA diagnostics but also opens new potential for a broad range of applications in the emerging molecular diagnostics market.",Fully Automated and Integrated Microfluidic Platform for Real-time Molecular Diagnosis of Methicillin-Resistant Staphylococcus Aureus (MRSA).,FP6,31 March 2010,01 October 2006,2095800.0 MAGWIRE,University of South Paris * Université Paris-Sud,information and communications technology,"Fast, high capacity, low form factor and low power non-volatile memories are a crucial enabler of today’s ICT. They are already an important part of all electronic systems, representing a growing market segment, and should increase their importance in the future en route towards the “Storage everywhere†society. The market today is divided between Flash NAND and hard disk, which both face severe limitations for the mid term future (2012-2014). The recent discovery that domain walls (DWs) can be moved under a small current without any magnetic field opens a perspective for a paradigm shift in mass storage design. This project aims at demonstrating the disruptive concept of the "storage track memory", which proposes to store information in DW sequences moving synchronously under current in patterned magnetic tracks. It reproduces the successful data sector memory organization of a hard disk in a solid state device with no mechanically moving parts. Our project aims at investigating the potential of a race track storage device beyond the 32nm technology node by proposing innovative solutions in the fields of materials, DW spin structure engineering, fabrication processes, architecture and CMOS integration. Our ultimate goal is to implement the integrated race track memory device in the standard CMOS 45nm technology node to fully benefit from the cost/scalability economics reflected by Moore’s law.",Magnetic Nanowires for High Density Non Volatile Memories,FP7,09 June 2015,10 January 2010,0.0 MAHEATT,University of Oslo * Universitetet i Oslo,transport,A.1.2. Project summary,Materials for high energy accumulators in traction and tools,FP7,03 July 2014,04 January 2009,0.0 MAIN,Fondazione Centro San Raffaele del Monte Tabor,information and communications technology,"Chronic inflammation is a systemic disorder resulting from the dysregulation of multiple, mechanistically unrelated higher order biological processes. This Consortium will promote the integration of multi-disciplinary research groups to achieve a thorough understanding of directed inflammatory cell migration towards and across injured tissues. To achieve its goals, the MAIN Consortium will be based on four developmental Research Programs (Tool Development Program, Target Identification Program, Target Validation Program and Drug Development Program), three Support Facilities (Imaging, Proteomics and Microarrays) and one Core Facility (Bioinformatics). The Research Programs are tightly interconnected in a logical sequence of highly integrated activities. The Tool Development Program (TDI) will develop technological tools that are instrumental to make advancements in the field of cell migration. The Target Identification Program (TIP) will identify signaling pathways and/or molecular networks involved in defined aspects of inflammatory cell migration. The Target Validation Program (TVP) will validate targets emerging from the TIP by testing them across in vitro and in vivo models, different inducing stimuli and manipulating conditions. The TVP combines the products of the TOP and the TIP to provide a unified explanation on how multiple 'inputs' received by inflammatory cells result in spatially and temporally coordinated 'outputs', affecting the migratory behavior of such cells. The Drug Development Program (DDP) will transfer selected targets into a pipeline of drug development, through the SMEs of the Consortium. The Support Facilities (Imaging, Microarrays and Proteomics) and the Bioinformatics Core will provide technological and biocomputational support to the programs. To spread excellence through education and training, MAIN will implement a Training and Education Program (TEP), with practical courses and workshops for gradua#",TARGETING CELL MIGRATION IN CHRONMIC INFLAMMATION,FP6,31 December 2008,01 January 2004,1.0E7 MAJIC-SPIN,Imperial College London,information and communications technology,"Semiconductor materials form the basis of modern electronics, communication, data storage and computing technologies. One of today’s major challenges for the development of future technologies is the realization of devices that control not only the electron charge, as in present electronics, but also its spin, setting the basis for future spintronics. Spintronics represents the concept of the synergetic and multifunctional use of charge and spin dynamics of electrons, aiming to go beyond the traditional dichotomy of semiconductor electronics and magnetic storage technology. The most direct method to induce spin-polarized electrons into a semiconductor is by introducing appropriate transition metal dopants producing a dilute magnetic semiconductor (DMS). The seamless integration of future spintronic architectures into nanodevices would require the fabrication 1-D DMS nanostructures in well defined architectures. In this project we propose to use a simple low-cost, low-temperature electrodeposition process to not only synthesise and characterise ZnO based bipolar DMS nanowire heterostructures but, even more importantly, fabricate an array of p-n and n-p-n junctions which could lead to novel nano-spintronic devices within ordered pre-defined nano-architectures. We will study the structural and functional properties of these heterostructures, which could have applications such as spin polarised LED and spin polarised bipolar junction transistor. By fully exploring the parameters controlling the growth and functionality of these materials we will try to gain a holistic understanding of the processing/structure/property relationships for this system. The ultimate goal of this project is to be able to design and fabricate specific nanowire heterostructures with tuneable magnetic and electrical properties which could lead to practical spintronic applications. Moreover this approach is inherently clean and scalable and easily integrated within current industrial practice.",Doped Magnetic ZnO p-n Junction Heterostructures for Nano-Spintronic Devices,FP7,06 June 2012,07 January 2008,168823.92 MAMBO,University of Sheffield,health,"Multiscale modelling of the human body is becoming an essential approach in large part of biomedical engineering research, as well as in the development of technologies for clinical applications, such as the Virtual Physiological Human. Bone is a hierarchical material and plays a fundamental role in the framework of the musculoskeletal system. In the last years the bone models at the tissue level (10-10000 microns) have been considered the weakest link in the multiscale modelling chain due the complexities of defining reliable experiments to validate them (i.e. to verify their accuracy in predicting the reality). The goal of the proposed study is to generate a set of accurate experiments for the validation of numerical models for cortical bone by using state of the art experimental techniques (micro-CT, nano-indentation), image processing (Digital Image Correlation) and engineering numerical methods (Finite Element (FE) models). To do so, a custom made jig will be designed to be able to perform stepwise loading on cortical bone samples inside a micro-CT. The sample's mechanical properties and the strain field will be computed between each loading level and compared to the outputs of the FE models generated from the acquired 3D images. The output of this project would be relevant for a variety of clinical and basic research applications: osteoporosis, osteoarthritis, regenerative skeletal medicine, fractures associate to bone tumours, better understanding of association between form and function in the skeleton, etc. Moreover, the bone research community would benefit from the sharing in Public Domain of reliable experimental results that could be used by other researchers as a benchmark for their modelling methods. The expertise of the researcher (Enrico Dall'Ara), the scientist in charge (Marco Viceconti) and the host organization (University of Sheffield) will provide the perfect environment to accomplish the goals of the project in the planned 24 months.",Methodologically Accurate Modelling of BOne: new experimental methods for the validation of cortical bone tissue computer models,FP7,30 April 2015,01 May 2013,221606.0 MAMINA,Braunschweig University of Technology * Technische Universität Braunschweig,transport,"The use of titanium, nickel-base, and cobalt-base alloys is necessary for the production of turbine parts and other components in the aerospace and the power generation industry due to their high strength even at elevated temperatures. On the other hand, these materials are known as the most difficult-to-machine metallic materials and so far, only small progress has been made to improve their machinability. During the production of turbine components up to 50% of the manufacturing costs can be related to machining. The reduction of the production costs by the optimization of the cutting process is mandatory for European manufacturers to remain internationally competitive. The MAMINA project will combine the work of 19 European universities, research institutions and industrial companies to analyse and improve the machinability of three selected alloys that are widely used in industry, namely Ti15V3Cr3Al3Sn, a titanium alloy, Inconel IN706, a nickel-base superalloy, and X40, a cobalt-base alloy. As the chip formation is one of the key factors influencing the machinability of these materials, this process will be studied in detail in a multidisciplinary approach. 24 ESR from the fields of theoretical physics, material science and mechanical engineering will be trained and work under the supervision of experienced scientists on cutting experiments, material analyses and simulations at the macro, micro- and nano-scale. Three different approaches will be made to improve the cutting process of the investigated alloys: 1. the introduction of enhanced manufacturing techniques, 2. the production of progressive tools with extended endurance, and 3. the development of free-machining alloys by the use of permanent and temporary alloying elements. The results will be transferred to applications by the industrial partners of the consortium. It is expected that the production costs during machining will be reduced up to 20%.","Macro, Micro and Nano Aspects of Machining",FP7,08 July 2014,09 January 2008,3684044.74 MAN,Stichting Materials Innovation Institute (M2I) * Materials Innovation Institute (M2I) Foundation,manufacturing,"Nanocomposite structures show enhanced mechanical properties (hardness and toughness) which are very interesting for protective purpose. The mechanical behavior of those materials is still not clear, and many different explanations (often contradictory) are present in the literature, which makes difficult the practical application of Nanocomposites. This project proposes to study the deformation mechanisms of these structures by a combined experimental and theoretical (computational) approach. This original approach will allow understanding phenomena which were still unapproachable until a few years ago and to clarify at once, the particular behavior of Nanocomposite structures. From the experimental side, a set of thin films with the abovementioned structures will be prepared by magnetron sputtering and characterized by several techniques, such as XRD, TEM, EELS, SEM, XPS, etc. Mechanical properties will be measured by nanoindentation. Further specific measurements will also be done for some selected samples, in order to evaluate “in situ†the deformation of these materials under stress by SEM, TEM/ED and XRD from a synchrotron source. From the theoretical side, molecular dynamics (MD) simulations will be done to evaluate the role of the crystal size, phase composition and presence of impurities in nanocomposite structures (and polycrystalline ones for comparison). The new knowledge, know-how and tools developed during this project will contribute to bring EU on the forefront of nanocomposite structures and their applications. Together with a training aiming at expending both technical skills (e.g in the field of nanoindentation, diffraction, TEM) and soft-skills (e.g. science management), this project will allow placing the candidate on his path for becoming a leading expert in the field of nanocomposites. In conclusion, this project will have a great impact not only on the researcher, but also on the participating institutions, and in Europe by extension.",Mechanical Analysis of Nanocomposites: an experimental and computational study of the mechanical behavior of polycrystalline and tough nanocomposite structures.,FP7,01 February 2014,01 March 2012,162248.8 MANANO,London South Bank University,energy,"Nanotechnologies and nanostructured materials is expected to be the most promising area of technological development and among the most likely to deliver substantial economic and societal benefits to the EU in the 21st century. It is a time of rapid advance in the development of these technologies, which can organize materials at the nanoscale and tailor their properties. This offers exciting possibilities in virtually all sectors of EU activity and could create entirely new industries. However, the exploitation of nanomaterials by European industry has been disappointing and one of the critical reasons for this is a general shortage of scientists/engineers with the knowledge to undertake relevant research and transfer the research findings into industrial production. The aim of the proposal is to encourage the very best researchers to get jobs in EU industry, where they can create these breakthrough opportunities. This will be achieved by giving them intellectually stimulating and industrially relevant research projects that will be undertaken in collaboration with universities and industry, and include industrial secondments together with comprehensive technical and complementary skills training. A network of 5 universities and research institutes, and 10 companies from 8 EU countries will be set up to carry out the integrated research and training programme. The research will include new nanomaterials for organic electronics, lithium ion batteries, solar cells on roof tiles and on flexible polymers, ultra-light aerogels for transportation and an innovative technique for 3D characterization at the nanoscale. The network will train a new generation of ESRs in the disciplines needed to understand nanotechnology and the complementary skills to enhance their career progression. All recruits employed in the programme will be ESRs and the partners will provide experienced researchers from their own staff without charge to the European Commission",MANUFACTURING AND APPLICATIONS OF NANOSTRUCTURED MATERIALS,FP7,31 March 2015,01 April 2011,2313945.0 MANET,University of York,information and communications technology,"The aim of my project is to calculate the electronic, structural, and dynamical transport properties of nanoscale devices, focusing on nanowires and systems used in molecular electronics. These systems will build the next generation of integrated circuitry in computers, and already find applications in light-emitting diodes and nano-scale sensors and actuators. The electronic structure of nanojunctions determines their physical, chemical, and transport properties. I will employ the GW approximation to calculate accurately the electronic structure of these systems. This is implemented very efficiently in the space-time approach developed by the group of Professor Godby, which will be used in this project. This approach is part of a large-scale collaboration, with groups throughout Europe, on electronic excitations and theoretical spectroscopy. The program also calculates total energies, which I will use to determine ground-state properties. The structure of polymers and many other systems involve weak forces which are beyond the reach of standard density-functional calculations. Finally, a linear-response approach has been implemented by Peter Bokes (STU. Bratislava) to calculate transport properties ab initio. I will expand this implementation, integrating the GW electronic structure, and applying it to determine the conductance of nanoscale devices. Integrated in an extensive network of researchers, my project will further the state-of-the-art in transport theory, and broaden the perspective of applications to nanoscale systems of technological interest. Both of these avenues are essential to research in the domain, and to the mastering of new molecular technologies. The high-quality training received in the host group and the opportunities for research and developing future themes will be an essential step in my scientific career.",MAny-body calculations of Nanoscale Electronic structure and Transport,FP6,31 October 2007,01 November 2005,161428.0 MANON,STMicroelectronics Srl,energy,"Cost control, production efficiency, cycle time and yield are critical quality benchmark for nanoelectronics productions. An increasingly important downside of nano-CMOS technology scaling is the fact that the scaling of feature sizes cannot be accompanied by a suitable scaling of geometric tolerances. In addition, when getting into deep miniaturized dimensions, phenomena like edges or surfaces roughness, or the fluctuation of the number of doping atoms within the channels are becoming increasingly significant. As a result, the figures of merit of a circuit, such as performance and power, have become extremely sensitive to uncontrollable statistical process variations (PV). To ensure stable manufacturability and secure high manufacturing yield, it is mandatory to manage complete design flows and to link traditional methods for design with Technology CAD models. In this context, multi-objective optimization algorithms and statistical analysis are essential on device and behavioral levels to secure high yielding by modeling the impact of inevitable process variations and doping fluctuations on IC performance. Statistical circuit modeling is a viable solution to nano-electronics production quality, on which the European Union is already investing. The project intends to create a partnership between academies, industry and SME so to create a Transfer of Knowledge between the organizations in order to pass the mathematical know how on multi-objective optimization, symbolic techniques and numerical statistical simulation on one side, the industrial design experience, real test cases availability and Electronic Design Automation (EDA) software modeling skills on the other. The scope of the research activity will be to create PV-aware and PV-robust circuit design techniques, tools and models in the frame of the analogue and mixed-signal circuit industrial design.",Methods for Advanced Multi-Objective Optimization for eDFY of complex Nano-scale Circuits,FP7,30 September 2014,01 October 2010,752481.0 MAP2,Kuratorium OFFIS eV,information and communications technology,"The MAP2 project will enable innovative extensions to existing products of BullDAST s.r.l., Italy, and ChipVision Design Systems AG, Germany. Both SMEs are technology leaders of Electronic Design Automation (EDA) tools for the design of power efficient systems. CMOS technologies below 90nm will enable adding value to many products and services, e.g., in mobile communication and transportation. However, the use of these technologies is severely limited by the increase in design cost and power consumption. This is a challenge, but also a large opportunity for EDA vendors. The current products of BullDAST and ChipVision are complementary working at different, but adjacent phases of the design chain. The ORINOCO tool by ChipVision allows power analysis and optimization at the pre-implementation phase, when the micro-architecture of a subsystem is designed from C or SystemC specifications. The PowerChecker tool by BullDAST performs architectural power estimation and optimization before RTL synthesis. The new prototype products of MAP2 will allow a seamless design flow between both tools and an automatic insertion of power management structures. This will be done at the earliest possible phases of design development, thus ensuring the highest efficiency. Such solutions will secure both SME EDA vendors a privileged position in their market. The new tools will also put the user of such tools in a favorable situation, because they will be able to design low power devices in the shortest possible time. The third SME partner will be such a user: CSEM, Switzerland, a world leading circuits and systems design house with a well established business in the domain of full-custom and semi-custom design services. The envisioned tool solution will not be possible without the contribution of two research performers, i.e., Politecnico di Torino, Italy and OFFIS, Germany, whose expertise and competence in the specific domain of low-power electronic design is recognized world-wide.","Micro-Architectural Power management:Methods, Algorithms and Prototype tools",FP6,30 April 2008,01 November 2006,740000.0 MAPNE,University College Dublin,health,"Memory loss is a central symptom in different diseases such as Alzheimer's disease, and represents a significant social and economic burden for a large percentage of European citizens. Neuronal cell adhesion molecules belonging to the immunoglobulin superfamily (IgCAMs) are known to be involved in brain development processes, and also contribute to the synaptic alterations connected with memory formation in adults. The goal of this project is to elucidate the molecular, biophysical and cellular mechanisms of directed movements of neuronal growth cones, and in particular how, upon binding to the extracellular matrix or to other cells, IgCAMs control cytoskeletal dynamics and therefore synaptic plasticity. The central hypothesis of this proposal is that adhesion-mediated growth cone guidance involves a force transduced by the cytoskeleton upon IgCAM adhesion, and that this mechanical signal further stimulates Src protein tyrosine kinase activation. In order to test this hypothesis, state-of-the-art techniques will be combined in a highly interdisciplinary manner. This project lies at the interface between mechanics, cell biology, biophysics and surface physics. The proposer will use a well-established cellular model system for growth cone studies (Aplysia), state-of-the-art molecular tools (recombinant IgCAM and Src biosensor) and a high-resolution force measurement system (Atomic Force Microscopy, AFM) coupled with FRET imaging. By applying the first molecule-specific AFM measurements to live neuronal growth cones, the proposer will measure the forces transduced by IgCAMs to the growth cone cytoskeleton and at correlating them with Src activity in real time, thereby proving the force-dependence of neuronal connectivity. This proposal is related to many of the FP7 research objectives, such as 'Nanosciences, Nanotechnologies, Materials and New Production Technologies" and "Health', specifically 'Research on the Brain and Related Diseases, Human Development and Ageing'",Mechanobiology of Aplysia neurons,FP7,06 March 2013,07 March 2011,178374.0 MAPS,Faserinstitut Bremen eV,transport,"The aim of this work is the complete characterisation of innovative prepreg systems based on carbon fibres and nanoparticle modified resins. After the test specimen production well known and long time approved mechanical test methods related the aircraft industry, as well as thermo-mechanical and chemical analyses will be used for the characterisation. Regarding the fibre-matrix adhesion a novel test method will be developed which is based on a tensile test for single fibres. Considering the long time experience in harmonising test methods for fibres and the experience of testing single natural, synthetic and high performance fibres a pull out test with a so called Dia-Stron equipment will be feasible resulting in a very simple and standarised test method to determine the fibre matrix adhesion.",Mechanical Testing and Analysis of innovative Prepreg Systems,FP7,08 July 2012,11 January 2009,33425.0 MARAGNANO,University of Southampton,environment,"The overall aim of this project is to establish the behaviour, fate and ecotoxicological effects of silver nanoparticles (AgNPs) in estuarine and coastal waters. Silver is a toxic element and increasingly used in NPs added to consumer products. This is resulting in AgNP release to marine waters. There is a lack of knowledge on AgNPs in marine systems, hampering development of legislation. The project has the following specific objectives:","The behaviour, fate and ecotoxicological effects of silver nanoparticles in estuarine and coastal waters",FP7,04 June 2017,05 January 2013,0.0 MARBIOTEC*EU-CN*,University Medicine of the Johannes Gutenberg-University Mainz * Universitätsmedizin der Johannes Gutenberg-Universität Mainz,health,"Marine biotechnology is one of the most exciting emerging fields of technology. It becomes more and more important in many areas of application such as the production of new drugs, food ingredients, agrochemicals, and cosmetics. More recently, it was found that some products of marine organisms are also of extreme importance in the rapidly growing field of nano(bio)technology, another technology of the future. These developments have been recognized by the European Commission as well as by national funding organizations in Europe and in China, which included marine biotechnology and nano(bio)technology in their priority research programmes. Both the European Research Area (ERA) and China as one of the main players in the Asian-Pacific Research Area (APRA) are in the worldwide lead in marine biotechnology and nano(bio)technology regarding to the number of publications and patent applications. However, different sectors of these technologies are differently developed in Europe and China, suggesting that a combination of the complementary expertise in these sectors will be of benefit to both partners. The proposed international staff exchange programme is based on three institutions in Europe and four institutions in China (universities and research organizations including marine stations) with a number of top-ranked research groups in the field of marine biotechnology, drug discovery/natural products chemistry, biomineralization and material sciences / nanotechnology. The objective of the project is to create an efficient and successful programme for the transfer of knowledge between the partners by the exchange and training of staff (both early-stage researchers and experienced researchers) of the participating institutions. The goal is a lasting integration of the research capacities in the European Union and China in the multidisciplinary field of marine biotechnology/nano(bio)technology.",European-Chinese Research Staff Exchange Cluster on Marine Biotechnology,FP7,31 July 2015,01 August 2010,680400.0 MARCONI,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"This project will study the control of electromagnetic (EM) waves using exceptional materials, and the application of such to the design of novel adaptive guiding and radiating structures. Two classes of unusual ‘materials’ with similarities in terms of modelling method and potentials applications are concerned here, constituting two inter-related research lines (i) the nano-scale graphene material and (ii) artificial materials based on periodic structures.",Nano-scale and Artificial Materials for Adaptive Electromagnetic Wave Control,FP7,03 July 2016,04 January 2012,0.0 MARS-EV,Fundacion Cidetec,energy,"MARS-EV aims to overcome the ageing phenomenon in Li-ion cells by focusing on the development of high-energy electrode materials (250 Wh/kg at cell level) via sustainable scaled-up synthesis and safe electrolyte systems with improved cycle life (> 3000 cycles at 100%DOD). Through industrial prototype cell assembly and testing coupled with modelling MARS-EV will improve the understanding of the ageing behaviour at the electrode and system levels. Finally, it will address a full life cycle assessment of the developed technology. MARS-EV proposal has six objectives: (i) synthesis of novel nano-structured, high voltage cathodes (Mn, Co and Ni phosphates and low-cobalt, Li-rich NMC) and high capacity anodes (Silicon alloys and interconversion oxides); (ii) development of green and safe, electrolyte chemistries, including ionic liquids, with high performance even at ambient and sub-ambient temperature, as well as electrolyte additives for safe high voltage cathode operation; (iii) investigation of the peculiar electrolyte properties and their interactions with anode and cathode materials; (iv) understanding the ageing and degradation processes with the support of modelling, in order to improve the electrode and electrolyte properties and, thus, their reciprocal interactions and their effects on battery lifetime; (v) realization of up to B5 format pre-industrial pouch cells with optimized electrode and electrolyte components and eco-designed durable packaging; and (vi) boost EU cell and battery manufacturers via the development of economic viable and technologically feasible advanced materials and processes, realization of high-energy, ageing-resistant, easily recyclable cells. MARS-EV brings together partners with complementary skills and expertise, including industry covering the complete chain from active materials suppliers to cell and battery manufacturers, thus ensuring that developments in MARS-EV will directly improve European battery production capacities.",Materials for Ageing Resistant Li-ion High Energy Storage for the Electric Vehicle,FP7,30 September 2017,01 October 2013,6575034.0 MAS,Infineon Technologies AG,information and communications technology,"The ENIAC JU project MAS is developing nanoelectronics components for applications in the field of health and wellness, and to create a development platform for the design of complete flexible, robust and safe mobile ambient-assisted-living systems. The project covers remote patient supervision using multi- parameter biosensors and telecommunications networks to improve the quality of the clinical environment as well as to encourage therapy at home. Implementation will require novel nanoelectronics technologies, interfaces, component designs and architectures for a common architectural approach.",Nanoelectronics for Mobile AAL Systems,FP7,03 January 2013,04 January 2010,4573493.0 MASC,University of Nottingham,health,"This proposal aims to harness breakthroughs in polymer science, nanotechnology and materials processing to create new classes of materials that mimic the architecture of the human body. The materials will be exploited to tackle grand challenges in stem cell science and in the development of new biomaterials that promote regeneration. The human body uses materials to impose architecture on populations of cells within developing or regenerating tissues. Architectural components of these tissues include three-dimensional spatial and temporal patterns of growth factors, spatial arrangements of multiple cell types and modulation of local elasticity. Orchestration of these architectural features is essential in the precise control of stem cell differentiation and tissue morphogenesis in vivo. This ERC Grant will create new classes of biomaterials that bridge the gap between the exquisite control of architecture in the developing human body and the crude structure imposed on cell populations in vitro during cell culture and biomaterials-assisted tissue repair. The research programme is organised into 2 major strands: TOOLS and DEMONSTRATORS. Within TOOLS, new materials and techniques will be invented that represent a step-change in our ability to impose architecture on stem cell populations in vitro. Within DEMONSTRATORS, 3 grand challenges in healthcare and stem cell science will be addressed through demonstrations that synthetic materials can be designed to match the architecture of our developing bodies. This interdisciplinary project will be undertaken by a team of interdisciplinary scientists within the Wolfson Centre for Stem Cells Tissue Engineering and Modelling (STEM). To undertake this research project help from collaborators across Europe is required. Existing and new collaborations will ensure that the most advanced materials science and stem cell biology is exploited to create world leading tools that radically change regenerative medicine.",MASC: Materials that Impose Architecture within Stem Cell Populations,FP7,31 December 2014,01 January 2010,2290856.0 MASCOT,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,health,"The overall objective of MASCOT is to exploit breakthroughs at the confluences of micro-, nano- and bio-technologies to create a low-cost minimally-invasive intelligent diagnosis system using a nanotechnology-based device for the isolation, enrichment and detection of rare cells from complex mixtures and using an array of nano-biosensors, integrated with micro-scale amplification, for the consecutive RNA/DNA analysis of the isolated rare cells. Advances in molecular biology and biosensor technology and the integration of nanostructured functional components in macro- and microsystems will facilitate the isolation of rare cells on the basis of novel markers, cell size, tailored surface chemistry and labeling with magnetic particles. The advantages of the exploited biosensors for RNA/DNA analysis are their sensitivity, their inherent selectivity, their versatility and their cost effectiveness. Addressing the health care requirement of the future of an individualised theranostic approach, the specific applications that will be demonstrated in MASCOT will be the isolation and RNA/DNA characterisation of both lung and breast cancer cells (more specifically, circulating tumour cells or CTC¿s), from respectively sputum and peripheral blood or bone marrow. The radical innovation proposed in MASCOT will result in a concrete prime deliverable of a technology platform of wide application and unquestionable socio-economic benefit, increasing European competitiveness whilst contributing considerably to the quality of life of the population and control of health care cost.",Integrated Microsystem for the Magnetic Isolation and Analysis of Single Circulating Tumour Cells for Oncology Diagnostics and Therapy Follow-up,FP6,31 March 2009,31 December 2005,2500000.0 MASPIC,University of Konstanz * Universität Konstanz,information and communications technology,"MaSpic will create an autonomous team at the University of Konstanz to investigate the interaction between magnetization, spin - polarized and pure diffusive spin currents using novel instrumentation and innovative theoretical approaches. A thorough understanding of the fundamental charge and spin transport interaction mechanisms, key to use of the spin degree of freedom for Spintronics, will be developed. To understand the interplay between spin-polarized charge currents and magnetization configurations (adiabatic vs. non-adiabatic electron transport), the reciprocal effects of magnetization on the current (magnetoresistance) and of the current on magnetization (spin transfer torque) will be correlated for the same spin structures. Non-intrusive high resolution imaging at variable temperature will be used to probe the non-adiabaticity and help understand the hotly debated influence of thermal excitations on transport. Pure diffusive spin currents will be efficiently generated and used to manipulate magnetization with ultra-low power dissipation. The poorly understood spin current generation by the Spin Hall Effect and spin current propagation will be probed by direct imaging and the sign of the spin accumulation and influence of scattering determined to separate intrinsic and extrinsic effects. For the measurements a unique variable temperature high resolution SEMPA imaging system will be acquired and further developed including ultra-fast electrical contacts. Theoretical modelling using an atomistic Heisenberg approach will go beyond the conventional micromagnetic calculations that are limited to 0K. To understand thermal transport effects, temperature dependent simulations with adiabatic and non-adiabatic spin torque terms will accompany experiments. Realistic lattice structures and heterostructures will be modelled to simulate the influence of the pure spin currents on the magnetization using spatially varying interface torque terms, not previously possible.",Spin currents in magnetic nanostructures,FP7,04 June 2016,08 January 2008,1610786.0 MASTER,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"The intended aim of this project is to explore the application potential of novel Spin-Transfer Oscillators (STO) as tunable and ultra-narrow band microwave radiation sources for mobile and wireless telecommunication technology. The main technological interest of STO devices, which correspond to nano-structured magnetic multilayer pumped by a spin-polarized electrical current and emitting microwave radiation, is their compatibility with monolithic integration. Our proposal specifically addresses the bottleneck issue of power conversion efficiency between dc current pumping and microwave emission of radiation. We propose to take advantage of the phase-locking mechanisms between coupled oscillators to increase significantly the device performance. Our primary objective is to engineer large arrays of coherently coupled oscillators. To achieve this goal, we shall investigate in detail 4 different types of coupling mechanism between neighboring oscillators which may induce phase-locking of the ensemble: 1) coupling through the self-generated microwave current, 2) coupling through the dipolar magnetic field, 3) coupling through the spin-diffusion of the conduction electrons, 4) coupling mediated by spin-waves. Achieving phase-locking between neighboring oscillators also requires substantial progress in our understanding of the fundamental mechanisms that are involved during momentum-transfer from spin-polarized current to the magnetic moments. Our secondary objective is to address both experimentally and theoretically 3 knowledge gaps: identifying (spatio-temporal profile and relaxation times) the fundamental spin-wave eigen-modes excited by a dc current in nano-structured magnetic heterojunctions; understanding the fundamental mechanism underlying non-local effects associated with the diffusion of spin-polarized electrons and its action on the dynamics of the whole system; investigating the magnetization dynamics of a nano-structure in the non-linear regime.",Microwave Amplification by Spin Transfer Emission Radiation,FP7,02 May 2014,09 January 2008,2044210.0 MATCHIT,University of Southern Denmark * Syddansk Universitet,health,"MATCHIT (MATrix for CHemical IT) will develop programmable information chemistry by introducing an addressable chemical container (chemtainer) production system and interfacing it with electronic computers via MEMS technology with regulatory feedback loops. As in the biological subcellular matrix, the chemical containers at the micro- and nanoscales will be self-assembling, replicable and self-repairing. At the nanoscale, DNA containers will provide a programmable and replicable chemistry in which positional information can be harnessed for a range of nanoscale utilities. At the microscale, containers based on DNA-labeled heterophase droplets and vesicles, will form microscopic labeled reaction vessels that can themselves determine their next processing steps. Their DNA-based addresses will be computable, enabling parallel chemical programming in a new multilevel architecture through autonomous address modification and resolution at the container-container, container-surface, and container-molecule levels, providing a concrete embedded application for DNA computing. This generic programmable information chemistry will not only be an enabling technology for 'immersed systems' IT applications in the life sciences, chemistry, and nanotechnology, but also promote a deeper understanding of the computational power of coupled production and information processes, as in biology, and provide a platform for building the more organic computers of the future. MATCHIT will investigate the general use of self-assembling chemtainers for information-intensive Chem-IT. The project will develop and apply multiscale physical simulation tools and novel embedded IT architectures to process and integrate modular chemical and digital information. It will integrate and disseminate multidisciplinary European activities in Chem-IT, supported by the European Center for Living Technology and provide an assessment of the likely long-term socio-technical impact of this powerful technology.",Matrix for Chemical IT,FP7,31 January 2013,01 February 2010,2770000.0 MATERIALS NANOMECH,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,information and communications technology,"The central aim of the proposed project is to develop a general nanomechanics of defects framework for the understanding and prediction of structure-properties relationships of nanoscale materials, components, and devices. This framework will be suitable for metal nanoparticles and nanorods, nanolayered films and core/shell nanowires, ultrafine grained bulk nanostructures, as well as carbon nanotubes and protein membrane nanotubes. While standard continuum mechanics and dislocation theory have been useful tools for addressing scientific and technological problems at macro and meso scales, their direct use is not suitable for nanoscale problems. Molecular dynamics simulations and their variants is a commonly used approach but also prohibitively expensive for realistic applications due to current computational limitations. The proposed project serves as a compromising alternative by developing a new methodology for understanding the evolution and stability of structural defects at nanosized volumes and advancing new continuum nanoelasticity and nanoplasticity models for capturing the deformation and fracture behavior of nanosized objects, devices and components. The results will be applicable to a variety of nanoscience and nanotechnology areas, including micro/nano opto-electronics, micro/nano electromechanical systems, bulk nanostructured metal processing and forming, as well as the structural stability of proteins in nanomembrane and nanotubular configurations. These results will be part of a book already in progress, and they will also be compiled as Lecture Notes in an existing Nanosciences and Nanotechnologies Curriculum in the host institution. The various workpackages of the project will also be among the topics of two planned international conferences-summer schools.","Nanomechanics of defects in solids: applications to nanolayers, nanoparticles, nanocrystals and biomaterials",FP7,11 June 2013,07 January 2009,203052.29 MATERIALS NANOMECH,RAS - Ioffe Physical-Technical Institute,information and communications technology,"The aim of the proposed project is to continue the research on a general nanomechanics of defects framework for the understanding and prediction of structure-properties relationships of nanoscale materials. This framework has to be suitable for metal nanoparticles and nanorods, nanolayered films and core/shell nanowires, ultrafine grained bulk nanostructures, as well as carbon nanotubes and protein membrane nanotubes. While standard continuum mechanics and dislocation theory have been useful tools for addressing scientific and technological problems at macro and meso scales, their direct use is not suitable for nanoscale problems. Molecular dynamics simulations and their variants is a commonly used approach but also prohibitively expensive for realistic applications due to current computational limitations. The proposed project serves as a compromising alternative by developing a new methodology for understanding the evolution and stability of structural defects at nanosized volumes and advancing new continuum nanoelasticity and nanoplasticity models for capturing the deformation and fracture behavior of nanosized objects, devices and components. The results will be applicable to a variety of nanoscience and nanotechnology areas, including micro/nano opto-electronics, micro/nano electromechanical systems, bulk nanostructured metal processing and forming. For the last objects, i.e. bulk nanostructured materials, experimental studies of their fracture and plastic behavior will be conducted to support the developed theory.","Nanomechanics of defects in solids: applications to nanolayers, nanoparticles, nanocrystals and biomaterials",FP7,09 April 2013,12 May 2012,11250.0 MATFLEXEND,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"MATFLEXEND investigates new materials which enable capacitive-mechanical energy harvesters with significantly improved power density and efficiency. Such materials will be durable, solution-processible, flexible, and therefore enable mass-production techniques including printing. The 'REWOD' principle (Reverse-Electrowetting-On-Dielectric) will be developed for small-scale energy scavenging, and a completely new variant of variable capacitor electrodes based on electrically conducting elastomers will be investigated which will lead to lightweight, low-maintenance, low cost electrical generators. High-k nano-doped polymer dielectrics will be developed with high breakdown voltage and low leakage. A new secondary battery architecture will be used, involving a novel polyHIPE / electrolyte element including RTILs, and novel nano-fibre composite electrodes, resulting in reconfigurable secondary lithium ion battery storage elements with higher temperature stability. High surface area 3D electrodes will be developed by EPD (electrophoretical deposition) to achieve the rate capability required in sensor nodes. Synergistically battery and harvester can use the same substrate, current collectors and hermetic encapsulation technology. At the same time these harvester/storage arrays can be structured into parallel and serial networks, to meet a variety of power and storage needs. Low cost harvesters are the key to consumer applications such as wearable electronics and smartcards as well as wireless sensors in a variety of application areas like medical/healthcare, sports and automotive. Demonstrations developed in the project include wearable applications and chip cards.",MATerials for FLEXible ENergy harvesting Devices,FP7,30 September 2016,01 October 2013,3849050.0 MATINA,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,manufacturing,"The aim of this project is the substantial improvement of cutting tools for the machining of nickel and titanium alloys. These alloys present several problems during machining operations, and as a result today there are important restrictions regarding tool performance that limit the economy and quality of the final parts. The most important fact is the trend to work harden, due to the localized overheating, and stick or adhere to the cutting tool surface. Therefore, tools with sharp edges, with a very good surface finish and low chemical affinity are required. The application of selected PVD nano-structured coatings with a thickness of less than 1 micron can improve the cutting tools without worsening at all the sharpness, making it possible that the Ni & Ti machining benefit from a technology that has already been successfully applied to machining other materials, i.e. steel alloys, but has showed little if any improvement in Ni & Ti. A PVD nano-structured coatings can decrease friction (lower overheating risk) allowing higher machining speeds or even avoiding the use of lubricant. Furthermore, a hard nano-structured coating with a nano-thickness can be applied to the tool maintaining its surface finishing and sharpness, thus delaying the presence of local wear defects; this will reduce material sticking and increase tool life. The objectives of the project will thus focus on i)longer cutting tool life ii)faster machining and iii)a reduction/elimination in the use of lubricants and coolants. This will translate into more economic Ni & Ti made parts, which are directly related to social targets widely assumed as not only important but mandatory by the European society: A)Sustainable development: more efficient use of energy resources as efficiency in power generation involves processes at higher temperatures, B)Environmentally friendly and affordable transport, C)Quality of life: dependable and affordable biomedical devices.",INNOVATIVE PVD NANO-COATINGS ON TOOLS FOR MACHINING TITANIUM AND NICKEL ALLOYS,FP6,24 July 2007,25 July 2005,536120.0 MATRANS,European Virtual Institute on Knowledge-based Multifunctional Materials AISBL,transport,"MATRANS aims at development of novel metal-ceramic functionally graded materials (FGMs) for aerospace and automotive applications in: (i) exhaust and propulsion systems, (ii) power transmission systems, and (iii) braking systems, with the main objective to enhance the mechanical properties of these materials through spatial variations of material composition and microstructure. Specifically, MATRANS deals with two groups of bulk FGMs: (i) ceramics-copper/copper alloys, (ii) ceramics-intermetallics. These FGM systems have not yet been used in the transport sectors targeted. The MATRANS methodology is problem oriented and comprehensive combining interrelated activities of material processing (core activity of the project), characterisation, modelling and demonstration. The processing will encompass starting materials (e.g. nanopowders) and the resulting FGMs. Characterisation of the FGMs will include detailed description of microstructure, measurements of physical and mechanical properties and residual stresses. The modelling will be carried out at a design phase and for the material response to combined thermomechanical loading and extreme service conditions. Extensive use of multiscale approaches and numerical methods will be made. The project addresses the joint design of the FGM and the structural component it is intended for. Economical and ecological aspects of processing are included. Risks aspects of material non-performance will be tackled, too. MATRANS has mobilized a critical mass of interdisciplinary expertise and highly specialized equipment. The consortium includes leading groups from materials science, physics, chemistry, mechanical engineering and computer science. The industry and SME involvement in the project is substantial. As the exploitation measures, the industrial partners will define business plans and start pilot cases during the project, followed by upscaling activities after the project end.",Micro and Nanocrystalline Functionally Graded Materials for Transport Applications,FP7,01 July 2015,02 January 2010,3600000.0 MBCTHERANOSTICSPION,Progress and Health Foundation * Fundación Pública Andaluza Progreso y Salud,health,"This project aims to develop a Theranostic Nanosystem allowing selective co-delivery of therapeutic agents with distinct physical chemical properties to target diseased cells in vivo. Besides good on-shelf and in vivo stability and low toxicity, the system must enable ratiometric control of cargo loading, avoid premature release of transported agents, allow controlled drug release at targeted locations, and its real-time, non-invasive, monitorization in vivo. Although adaptable to other applications, the system here will transport two chemotherapeutic drugs (Doxorubicin and Cisplatin), one RNA (antagomir-10b) and one peptide (H5WYG), coated with PEG-folate conjugate to confer both stealthness and cell specific tropism to the whole. The nanosystem will be fabricated, characterized in vitro and optimized, and the function of each component will be examined in cultured murine Metastatic Breast Cancer 4T1 cells. The latter forms highly aggressive metastatic tumors in immune competent BALB/c mice that recapitulate the human disease. 4T1 overexpresses folate receptor, which will interact with the system and induce its internalization through the endosomal pathway. These cells are sensitive to doxorubicin and cisplatin, and their metastatic character is inhibited by antagomir-10b. Whilst chemotherapeutic drugs escape the endosome by simple diffusion, escape of antagomir-10b from will be facilitated by an endosomolytic peptide co-transported by the system. Acidification of the endosome will trigger drug release and endosomo-lysis. The correct functioning of the system should inhibit metastatic spreading of 4T1 cells in mice and kill primary and secondary tumors, offering an ideal model to optimize performance. A Superparamagnetic Iron Oxide core will allow in vivo monitorization of distribution and therapeutic response using Magnetic Resonance Imaging. This methodology will pave the way for additional strategies that could be applied to other cancer types.",Development and in vivo validation of a SPION based Theranostic nanosystem for the treatment of Metastatic Breast Cancer.,FP7,24 October 2016,25 October 2014,173370.0 MC2ACCESS,Chalmers University of Technology * Chalmers Tekniska Högskola,manufacturing,"Access is offered to advanced micro- and nanotechnology device processing environments for microwave and photonic devices and for nanotechnology at the Department of Microtechnology and Nanoscience (MC2) at Chalmers University of Technology in Göteborg, Sweden. The laboratory provides means to develop process steps, process sequences, and components in small/medium quantities. In 1240 m2 clean-room area more than 150 tools are available, including two e-beam lithography systems (one of which is a JBX 9300FS from JEOL with a spot diameter of 4 nm and a minimum feature size of below 10 nm), silicon processing on up to 150 mm wafers, III-V and wide bandgap processing, molecular beam epitaxy, CVD and dry etching systems.","Access to research environments and advanced processing facilities in microwave electronics, photonics and nanotechnology at the MC2 facility",FP6,31 March 2010,01 January 2006,1593600.0 MCIBC,University of Leeds,health,"β -2 microglobulin (β-2-m) is a 99 residue protein with an immunoglobulin fold. β-2-m is usually found as a part of the major histocompatibility 1 complex. This protein aggregates to form amyloid fibrils in osteoarticular tissues, leading to pathological bone destruction and the condition known as dialysis-related amyloidosis (DRA). The accumulation of β-2-m deposits has been shown to cause arthralgias, destructive osteoarthropaties and carpal tunnel syndrome. The host laboratory has characterized β-2-m amyloid assembly and developed a molecular description of the folding and aggregation mechanisms of β-2-m under relevant conditions, but the factor or factors responsible of the initiation of the aggregation process are still unknown. β-2-m amyloid accumulates in connective tissue, causing the pathological consequences of the disease. Collagen is one of the main components of this tissue and has been proposed to be a possible contributing factor in the initiation of aggregation. Consistent with this, studies with ex vivo amyloid material show that there is a strict association between β-2-m and collagen within joints, while biochemical experiments have revealed tight binding between β-2-m and collagen. This project will focus on the study of the interactions between collagen and β-2-m and its consequences for the formation of amyloid fibrils from a molecular viewpoint. We will study the specificity of interaction of β-2-m with different collagen sequence patterns and the influence of collagen on β-2-m stability, dynamics, and aggregation rate. For this project a complementary set of biophysical techniques, including mass spectroscometry, NMR, fluorescence, infrared spectroscopy and electron microscopy, will be used. The results will facilitate the design of small molecules or nanoparticles (copolimer, dendirmers) directed to interfere with the interaction of β-2-m with collegen as a route toward prevention of β-2-m fibrillization.",Molecular characterization of the interaction of β -2 microglobulin with collagen,FP7,31 January 2015,01 February 2013,200371.0 MCMACM,Lublin University of Technology * Politechnika Lubelska,transport,"The project aims for establishing new areas of competence at Lublin University of Technology (LUT) comprising modelling of composite materials and their applications to civil, mechanical and aircraft engineering. The major goal and novelty of the project is to link together nano-, micro-, meso- and macro-scales to get perfect description of the composite behaviour under different loadings, temperature and environmental conditions. The project implementation will result in creating a leading research and education centre in the Middle-East part of Europe in modern composite materials and their applications to construction elements. With regard to research, it is envisaged to develop modern approaches to engineering structures made of composite and smart materials using non-linear theory for static and dynamic loading, new concepts of control, optimisation of the structure and methods of experimental investigations and identification of models. With regard to education, it is planned to provide teaching at the European level, consistent with EC priorities – by introducing new courses to existing Ph.D. studies programme, arranging advanced courses for the LUT staff and training LUT staff at partner institutions. It is envisaged to strengthen co-operation with the local industry: Polish Aviation Work Swidnik S.A. , Wiz-Art Ltd – local SME and new company “AERONET- Aeronautic Valley”, promote new technologies of composites and structural elements production and foster innovation to the local enterprises. In terms of socio-economical aspects, ToK project will help Lublin area (where LUT is situated)- as less favoured region - to compensate disproportion.The proposed project will increase international competitiveness of LUT in the field of composite materials and their applications to engineering structures. Involvement of LUT in joint European research projects will be enhanced by increase of long term research and collaborative capacity of LUT with EU institut","Modern Composite Materials Applied in Aerospace, Civil and Mechanical Engineering: Theoretical Modelling and Experimental Verification",FP6,31 March 2009,01 April 2005,1060403.0 MEAD-ET,University of Auvergne Clermont-Ferrand 1 * Université d'Auvergne Clermont-Ferrand 1,health,"Recently a program of development of super active carbonic adsorbents for the deep purification of whole blood and blood plasma was realised in the series of joint projects between The EU partners and Ukraine. As a result, nanostructured activated carbons with mass-fractal internal structure and unique capacity towards tightly protein-bound toxins, uncoated or coated with albumin conformers have been synthesized. These materials have been tested and approved for clinical use in Ukraine and Uzbekistan expressly for the treatment of severe hepatic insufficiency, renal insufficiency and multi-organ failure. The goal of this project is the transfer of these findings to a new version of nanostructured carbon, synthesized on the base of phenol-formaldehyde resin modified and coated with haemocompatible dextrans and its sulfated derivates in the Department of Physico-Chemical Mechanisms of Adsorptive Detoxification in the Institute of Experimental Pathology, Oncology and Radiobiology Nat. Acad. of Sci of Ukraine and studied in the School of Pharmacy and Biomolecular Sciences at the University of Brighton (biocompatibility, inflammatory mediator adsorption) and the Laboratory of Immunology, School of Medicine and Pharmacy, University of Clermont-Ferrand (investigation of immunoadsorptive properties of nanostructured carbonic adsorbents coated with sulfated polysaccharides). This program gives the opportunity to cultivate a high scientific quality consortium consisting of 2 European and 1 third country academic institute, with the aim to sustain and create new collaborative partnerships between EU partners and Ukraine, and transfer knowledge and technologies in one of the most exciting fields of modern biomaterial science. Focusing on the development of extracorporeal methods for toxin removal, for the treatment of many life threatening conditions and chronic conditions, that result in a low quality of patient life.",Novel medical adsorbents for extracorporeal treatment of life threatening conditions.,FP7,30 November 2014,01 December 2010,113400.0 MECARTUBES,London School of Economics and Political Science,health,"Metal-filled carbon nanotubes (CNTs) have attracted intense attention in recent years especially with view to applications in biomedicine such as drug delivery systems. This project concerns the development of in-situ filling CNTs with metals. Different magnetic metals such as Fe, Co, Ni and their alloys will be encapsulated in the inner cavity of the CNTs during growth. In order to achieve this objective, novel carbon vapor deposition experiments for the continuous process of filling CNTs will be explored. The methods proposed have the advantage that the growth and filling of the nanotubes take place simultaneously. The transition from lab to a large scale production will be explored. They will be based on the pyrolysis of metal-organic compounds and catalytic pyrolysis varying catalyst concentration in conjuction with filling facilitating compounds. The influence of the processing parameters (i.e deposition time, reaction temperature or influence of the catalyst particles) on the structure and magnetic properties will be studied in order to elucidate important parameters for the controlled mechanism formation and encapsulation of metallic particles. Structural and chemical analysis of metal-filled CNTs will be carried out by means of scanning and transmision electron microscopy, electron energy-loss spectroscopy or raman spectroscopy. Magnetic properties will be also evaluated. Functionalization of CNTs is the precondition for their application in medicine. In this project, functionalization of the surface of filled-CNTs will be explored mainly by covalent functionalizations through oxidation with strong acids and employing the 1, 3 dipolar-cycloaddition mechanism. As part of the last activity of the research, the project will overcome preliminary tests about the binding of therapeutic molecules with some kind of pharmacological activity for the treatment of complex diseases where activity is required at specific sites in the human body.",IN-SITU FILLING OF CARBON NANOTUBES WITH METALS,FP7,30 September 2013,01 October 2011,200049.0 MECHCOMM,Karolinska Institute * Karolinska Institutet,health,"Cell-to-cell communication pathways coordinate cellular functions in multicellular organisms. Cells that are nearest neighbours can communicate through specific interactions between ligand and receptor proteins present in their respective cell membranes. The objective of this research program is to address the hypothesis that the physical context of the ligand/receptor interaction contributes to defining the fundamental mechanisms of action of cell-to-cell communication pathways and their cellular outcomes. The research program relies on the development of tools that provide well-defined physical inputs to cells, not confounded by simultaneous changes in chemical inputs. Therefore, beyond state-of-the-art developments in nanotechnology are here integrated with cell biology. In particular, DNA origami technology is applied to the development of ligand nanoclusters with customized spatial organization and mechanical properties. These ligand nanoclusters are used to probe the roles of physical properties of the ligand presentation on the activation of intracellular signalling pathways. We will focus on the ephrin/Eph cell-to-cell communication pathway, which regulates embryonic development and the homeostasis of adult organs. ephrin/Eph signalling is commonly disrupted in cancer, showing tumour suppressing or tumour promoting character. The mechanisms that generate the diversity of outcomes of the ephrin/Eph pathway are largely unknown. We will use DNA origami/ephrin ligand nanoclusters to investigate whether the spatial organization and mechanical properties of ephrin ligand assemblies impact Eph receptor function and contribute to generating diversity in the pathway. Our novel approach is readily transferrable to the study of other signalling pathways. We aim to generate a knowledge foundation for the roles of mechanotransduction, the conversion of physical to biochemical signals, in cell-to-cell communication mediated by membrane-bound ligands and receptors.",Mechanotransduction in Cell-to-Cell Communication,FP7,31 May 2019,01 June 2014,2292100.0 MEDDELCOAT,University of Leuven * Katholieke Universiteit Leuven,health,"Most common reasons for revision surgery of implants are loosening (65%), dislocation (9%) and infection (7%). The revision rate of hip replacement surgery is between 10-20%. Rates of implant loss for dental implants is 15% over a 5-year period. Biofilm formation is the major pathogenic factor. The project, driven by 7 dedicated complementary Hi-Tech SMEs, aims at gaining the scientific and processing knowledge to assist the SMEs in the development of the next generation multi-functional coatings for orthopaedic and dental implants and fixation devices for adequate implant fixation, bioresorbability, bioactivity, biocompatibility as well as biofilm formation inhibiting functionality, that should drastically reduce the currently experienced need for implant revisions due to loosening and infections. The envisaged radical innovations and major breakthroughs are: (a) development of new substrates and coatings with enhanced biocompatibility, (b) development of radically new or improvement of existing coating techniques for processing bioresorbable and biocompatible coatings with a graded interface and tailored porosity (c), in-depth understanding of implant substrate/coating/bone interfacial structure, design and engineering of optimal implant fixation, (d) knowledge on biofilm formation and inhibition (e) formulation and evaluation of biofilm inhibitors incorporated into the coating. The project addresses the integration of nanotechnologies, materials science and advanced technologies to improve health and quality of life of European citizens and creating wealth through novel knowledge-based and sustainable products (biomaterials) and processes (coatings), by means of fostering breakthrough applications through the integration of multi-disciplinary research developments. The project will contribute to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of an SME-intensive sector.",Multifunctional bioresorbable biocompatible coatings with biofilm inhibition and optimal implant fixation,FP6,31 March 2011,01 October 2006,3299280.0 MEDIF-2,Weizmann Institute of Science,health,"Back in 1992 we have found that nanoparticles of inorganic compounds with layered (2D) structure, including MoS2, NiBr2, Cs2O and many others, form hollow closed nanostructures- i.e. fullerene-like nanoparticles (IF) and nanotubes (INT). These nanoparticles serve as very good solid lubricants and are now exploited commercially. Using the leverage of the ERC project we have recently made major progress with the synthesis of new IF and INT, including SnS2 nanotubes and MoS2 nanooctahedra. We also found that Re doping of the these nanoparticles leads to remarkable changes in their physio-chemical behavior, including making them superlubricants (friction coefficient approaching 0.01). Based on these advancements, in both the materials synthesis and bio-medical studies, we propose to develop a number of new medical technologies which will be licensed to a start-up company at the end of this project. In order to achieve this goal we will employ a multifaceted technological approach. 1. Develop new self-lubricating coatings based the IF nanoparticles; 2. Explore a number of promising new medical applications which are associated with the low friction and surface energy of the IF NP, and 3. Embark on extensive bio-toxicity-bio-compatebility studies.",Medical Applications of IF nanoparticles,FP7,28 February 2014,01 March 2013,150000.0 MEDITRANS,Universiteit Utrecht * Utrecht University,health,"MEDITRANS will develop systems for targeted delivery of nanomedicines, which will be broadly applicable to disease. The focus is on chronic inflammatory disorders and cancer. Such industrially developed targeted products will improve therapy and in vivo visualisation of drug delivery/release processes. Nanocarriers (nanoparticles, nanotubes, fullerenes), endowed with high targeting capabilities, will be designed in parallel with MRI probes that report on localisation of the targeted nanoparticulates, specific bio-markers, and the drug release process (MRI-guided drug delivery). For reproducible behaviour in vivo, these nanomedicines containing drug payloads (e.g. pDNA, siRNA, small molecular weight agents) will have their physicochemical/stability properties characterised. 'Smart' delivery systems, tested in vitro, able to recognise the target, and to cross-relevant biological barriers, will be investigated for their responsiveness to the microenvironment of the target site (e.g. local pH). Control of drug release, triggered by external physical means (e.g. temperature, light, magnetism, ultrasound) or by local stimuli within the pathological site (e.g. pH, enzymatic activity) will be investigated in vitro. Ways to direct the intracellular trafficking of nanocarriers, to achieve improved interaction with the intracellular target location, will be investigated. In vivo applicability will be evaluated in clinically relevant models of disease. Toxicology aspects, industrial scale-up feasibility, long term stability, and feasibility to prepare clinical grade material will be covered. Dissemination, training and exploitation will be done. MEDITRANS, duration 4 years, is a timely, interdisciplinary IP at the forefront of targeted nanomedicine, with a budget of 16.1M Euro, a grant of 11M Euro (68%), and 1581.75 person-months effort. The 30 partners (12 European countries) are from industry (8), SMEs (5), universities (11), and research institutes (6).",TARGETED DELIVERY OF NANOMEDICINE,FP6,31 March 2011,01 January 2007,1.072870174E7 MEGA-XUV,University of Neuchatel * Université de Neuchâtel,manufacturing,"Coherent extreme ultraviolet (XUV) light sources open up new opportunities for science and technology. Promising examples are attosecond metrology, spectroscopic and structural analysis of matter on a nanometer scale, high resolution XUV-microscopy and lithography. The most promising technique for table-top sources is femtosecond laser-driven high-harmonic generation (HHG) in gases. Unfortunately, their XUV photon flux is not sufficient for most applications. This is caused by the low average power of the kHz repetition rate driving lasers (<10 W) and the poor conversion efficiency (<10-6). Following the traditional path of increasing the power, numerous research teams are engineering larger and more complex femtosecond high-power amplifier systems, which are supposed to provide several kilowatts of average power in the next decade. However, it is questionable if such systems can easily serve as tool for further scientific studies with XUV light.",Efficient megahertz coherent XUV light source,FP7,02 April 2019,03 January 2012,0.0 MEGAFRAME,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"Imaging of ultra-fast, time-correlated, molecular processes in physics and the life-sciences is placing increased demands on camera technology. A new detection paradigm is necessary whereby a solid-state sensor array of pixels sensitive to a single photon is assembled. Pixels composed of detectors called Single Photon Avalanche Diodes (SPADs) will be integrated for the first time in an advanced, deep-submicron CMOS process. Large arrays of SPADs interfacing to networks of parallel digital processing units on the same chip will provide record levels of timing accuracy, sensitivity and speed. The MEGAFRAME 128x128 pixel prototype will be capable of a sustained 1,000,000 frames per second with 50 picosec time uncertainty. This will re-establish European excellence in the field of ultra-high speed video capture. To access and process the extremely high data rates generated by the pixel array, novel system architectures must be developed. Another essential advance is a highly reproducible optical concentrator array to reclaim the fill-factor lost to pixel-level infrastructure. The new imaging system will be evaluated using emerging time-correlated methods such as Fluorescence Lifetime Imaging Microscopy and Correlation Spectroscopy, Förster Resonance Energy Transfer, and Voltage-Sensitive Dye imaging. Resolutions and frame rates at least ten times higher than today's solutions will be achieved. Mechanisms such as calcium signalling will be monitored on single cells at 1microsec steps for the first time. Future advances in proteomics, systems biology and drug discovery are dependent on such improved understanding of intra-cellular processes. Major contributions to multi-processing architecture, flow-control engineering and fast phenomena observation are also expected. The consortium is a unique combination of imaging technology innovators, a leading European semiconductor manufacturer and a diverse end-user community from the life-sciences, physics and chemistry.","Million Frame Per Second, Time-Correlated Single Photon Camera",FP6,30 April 2010,30 May 2006,1850000.0 MEKIMI,University College London,information and communications technology,"Molecular Electronics (ME) is predicted to match in the beyond CMOS scenario the relevance of Microelectronics. Expectations are remarkable, especially if Molecular Quantum Dot Cellular Automata (MQCA) is the technology of",Molecular Electronics aKIn MIcroelectronics,FP7,09 June 2018,10 January 2014,0.0 MEM-S,University Medicine of the Johannes Gutenberg-University Mainz * Universitätsmedizin der Johannes Gutenberg-Universität Mainz,health,"There is strong interest in the development of novel functionalized membranes which can be used as microsieves, as a component of integrated analytical systems, in food processing, drug discovery and diagnostic applications. This project is based on a combination of three break-through technologies, developed by the applicants in the past, with high impact for nano(bio)technological application: (i) the S-layer technology allowing the construction of nanoporous protein lattices, (ii) the biocatalytic formation of inorganic materials by silicatein, a group of unique enzymes capable to catalyze the formation of porous silica from soluble precursors, and (iii) the sol-gel technique for encapsulation (immobilization) of biomolecules serving as biocatalyst or as a component of sensors. The goal of this project is to design and fabricate - based on molecular biology inspired approaches - nano-porous bio-inorganic membranes with novel functionalities for industrial application. These membranes will be formed by S-layer proteins, which are able to assemble to highly ordered structures of defined pore-size, and recombinant silicateins or silicatein fusion proteins. The hydrated silica glass layer formed by silicatein will be used to encase biocatalysts (enzymes) or antibodies against small molecules as sample prep- or sensor components of integrated systems. The innovative type of the functionalized membranes developed in this project thus exploits two principles: (i) protein self-assembly and - and this has not been done before - (ii) enzymatic (silicatein-mediated) deposition of inorganic material used for reinforcement of the membranes as well as for encasing biomolecules, providing the membranes with new functionalities. The new technique will be exploited by three research-based SMEs and the enduser involved in the project, in microfluidics based sample processing and micro-array development, in industrial nanosieves, as well as in sensors in drinking water systems.",Bottom-up design and fabrication of industrial bio-inorganic nano-porous membranes with novel functionalities based on principles of protein self-assembly and biomineralization,FP7,31 December 2012,01 January 2010,2816819.0 MEMBAQ,DHI - Institut For Vand Og Miljø,environment,"In all living cells, channels transporting water - aquaporins - exist. They are proteins, which only transport pure H2O molecules. They have a unique selectivity and are extremely efficient being nature's own membrane systems. The purpose is to investigate whether these unique features can be industrially exploited: Recombinant aquaporin molecules will be embedded into water filtration membranes. Nano-biotechnological research of water transport in various organisms show that aquaporins have 100% selectivity: Only water molecules pass. They also maintain high water permeation rates. Membrane technology is another rapidly developing technology within filtration and separation. Substantial research is done to enhance efficiency of membranes. The MEMBAQ project combines these two research spearheads. This combination has never been done before. A new filtration membrane with aquaporins is in theory up to 50 times more efficient (energy input reduction). It is truly radical innovation of the water industries, for instance for water purification (billions of EUR is spent every year), salinity gradient energy production (exploitable potential is 2000 TWh annually), waste water reclamation (water re-use). The MEMBAQ project will 1) produce recombinant aquaporin, 2) design nanotechnological membrane by means of computer simulation, 3) incorporate aquaporins into stable membranes, 4) engineer membranes based on characterising towards pressure, ph etc., 5) and finally test such membranes in three applications: Water purification, osmotic energy, and waste water reclamation for re-use. US and Japan invest significantly more per capita than EU in nanotechnology. This gap is expected to widen in the next few years. In MEMBAQ, we use real market needs in the water sector as a driver for accelerated research and innovation in nanotechnology. Enormous potentials in filtering other fluids and gasses with natural proteins embedded in membranes exist.",Incorporation of Aquaporins in Membranes for Industrial Applications,FP6,31 March 2010,01 October 2006,2100000.0 MEMBRANE NANOTUBES,Imperial College London,health,"Recently, membrane nanotubes have been found to connect many types of cells, including cells of the immune system. These nanotubes contain actin filaments, are not attached to substrate, and are distinct from other cell tethers such as filopodia and membrane bridges. Potentially, specific coupling of cells over long distances can have great significance, and evidence is mounting to suggest that membrane nanotubes may have a role, e.g., in specific cell-to-cell signalling and trafficking of pathogens between cells. However, the molecular basis for the nanotubes formation is almost completely unknown. This is an urgent goal for research in this area since functional tests for the importance of membrane nanotubes are currently hampered by a lack of knowledge regarding specific ways to inhibit or augment nanotube formation. Thus, I aim to address this issue by answering three specific questions: 1) Does the formation of membrane nanotubes and filopodia require the same proteins? This will be assessed by knocking-down the production of proteins involved in filopodia formation, and observing the frequency of nanotube formation, their length, and their stability. In parallel I will test for the presence of these proteins in membrane nanotubes using mAb and/or fluorescent protein-tagged proteins as available. 2) Next I will test whether proteins known to be involved in the morphological changes the underlie immune cell spreading and contraction are required for the formation of the nanotubes. The effects of these proteins will be tested by knocking-down proteins and additionally, changes in cytoskeletal and membrane tension that are coupled to changes in cytoskeleton reorganization will be evaluated using optical tweezers. 3) Finally, I will test if the membrane protein and lipid composition in nanotubes is different from that in the rest of the cell surface membrane. If a specific composition is revealed, this may imply specific functions for the nanotube membrane.",Determining the molecular basis for the formation of membrane nanotubes between immune cells,FP7,31 August 2010,01 September 2009,91809.0 MEMBRANE PROTEINS,University of Copenhagen * Københavns Universitet,health,"Knowledge of the structure of proteins can provide an in-depth understanding of biology and lead to critical insights into the origins of human disease. Numerous proteins important in biology and disease are, however, not amenable to structural analysis by traditional methods. A family of proteins that are notoriously difficult to study are membrane proteins. Membrane proteins are extremely important to study as they play pivotal roles in most biochemical processes of the cell, account for up to 25 percent of all proteins in humans, and represent nearly two-thirds of the proteins that can be targeted by drugs. These proteins are, however, difficult to access experimentally due to their hydrophobic nature and because they need to be associated with lipids from the cell membrane. Most techniques are not readily compatible with the combination of lipids and proteins, especially those that are used to reveal the three-dimensional structure of proteins (i.e. NMR spectroscopy or x-ray crystallography). Alternative techniques are needed to gain insight into the structure of membrane-bound proteins. We propose to meet this challenge by employing an alternative technology that use mass spectrometry to measure the hydrogen/deuterium exchange (HX) of proteins in solution. The objective of this project proposal is to apply HX-MS technology to study two 'difficult' membrane proteins of key biological function: (1) the T-cell receptor (TCR) and (2) the Epidermal Growth Factor Receptor (EGFR). By inserting these receptors into nanoscale lipid bilayer discs and measuring the HX of the proteins, we will extract detailed information about their higher-order structure and molecular interactions using only small amounts of material at dilute biological conditions. The proposed project is innovative as we combine nanotechnology with alternative analytical methodology to supply critical and currently missing structural details about two important cell-surface receptor proteins.",Visualizing the structure and function of elusive membrane receptor proteins of the human cell,FP7,31 July 2015,01 August 2011,100000.0 MEMBRANENANOPART,University College Dublin,environment,"The central goal of our proposal is to develop physically justified models and computational tools to quantitatively describe and understand the molecular mechanisms of nanoparticle-cell membrane interactions, which we consider to be a crucial point in any predictive model of nanoparticle toxicity. We consider mechanisms of nanoparticle protein corona formation, the protective function of the membrane, nanoparticle uptake into the cell, and the effect of nanoparticles on the cell membrane. We plan to develop a consistent multiscale simulation scheme starting from nanoparticle-biomolecule interaction at the atomistic scale using molecular dynamics simulation, and then systematically constructing coarse-grained mesoscale models for simulating the structure and dynamics of the cell membrane perturbed by nanoparticles at the physiologically relevant time and length scales. We will develop and test a universal method for evaluating the rates of nanoparticle translocation through membranes and evaluate associated specific toxicity effects. Based on the information acquired from the simulations and analyzed together with available experimental data, the toxicological impact will be deduced. We will apply our approach to a range of common engineered nanoparticles, relating their physicochemical properties such as size and shape, surface charge, hydrophobicity (logP), and plasma protein binding affinity to the toxicological effects and develop a test suite allowing to make toxicity prediction on the basis of purely computational or limited in vitro screening tests.",Modelling the mechanisms of nanoparticle-lipid interactions and nanoparticle effects on cell membrane structure and function,FP7,12 July 2017,01 January 2013,999810.0 MEMBRIDGE,European Membrane House,environment,"Membranes are nano-/micro-porous multifunctional materials the main property of which is permselectivity regarding to different ionic and molecular species. This property results in a great number of applications in processes of aqueous and gaseous mixture separation. The small material and energy consumption and high eco-efficiency of separation by membranes determine strategic role of membrane processes as technologies making a bridge between industry and environment. The main objective of the proposal is to make a step towards reaching an effective integration of research activities, training, equipment sharing, and thus answer the needs for a coordinated membrane science and technology R&D in Europe and Russia oriented primarily at development of eco-efficient methods in industry. This objective replies to one of most important priorities of FP7: Elaboration of concepts aimed at sustainable development, and societal innovation. This objective will be attained by rapprochement of two membrane networks: Network of Excellence NanoMemPro in Europe and Russian Membrane Network being in the way of formation. The project foresees the organisation of two meetings of 25 representatives of European institutions belonging to NanoMemPro and of the equivalent number of Russian and NIS scientists. The basis for a European-Russian Membrane Science and Innovation Technology Platform will be founded as well. As a result of the project, a well structured programme/concept of scientific collaboration and diverse actions (in the field of researches, training, equipment sharing, person mobility, technological innovation) for the next several years will be elaborated. The proposed project should prepare grounds for further larger and amplified actions between European and Russian membrane networks following the axe of environmental protection, in the framework of FP7 and other international and regional programmes.",Bridge between environment and industry designed by membrane technology,FP7,04 June 2013,05 January 2009,268000.0 MEMOTUMCELLMACH,IMDEA Nanoscience Institute * IMDEA Nanociencia,health,"The past decade has seen substantial advances in our understanding of cancer molecular biology and the technologies available to study it, emphasising the importance of the molecular mechanisms of carcinogenesis in cancer research. We now face having to therapeutically aim for many less common targets rather than a few all-cancer present targets. Effective single molecular targets therapies are generally not sufficient to elicit durable clinical responses and the development of drug resistance is an increasing problem. Consideration of only a single drug–target interaction in vivo has proven to be overly simplistic. The ultimate goal of this proposal is to generate metallodrugs whose mechanism of action is understood and whose targets are identified. These multitargeting drugs would be a more realistic option by leading rational co-extinction strategies for specific cancers. Current cross-discipline trainings make possible the alliance of inorganic chemistry with cell and molecular biology. The unprecedented potential for design of metallodrugs has not been overseen and medicinal bioinorganic chemistry is rapidly expanding. This interdisciplinary proposal involves chemistry, biology and physics, with potential not only for the discovery of novel medicines for cancer treatment, but also for the development of new methodologies to modulate and deconvolute the technology behind the tumour cell machinery. By uncovering the operating principles and mechanisms of action of our metallodrugs at the nanoscale (i.e. subcellular level) we aim to inform on what biological context its destruction would lead to cell death and also to tumour regression. These metallo-medicines will exploit the extraordinary features of transition metal complexes, in particular the capability for in tumour activation, and the possibility of being loaded into nanocarriers, conferring control on the drug reactivity, and thus minimising undesired side effects, often responsible for drug failure.",Metallodrugs to Modulate Tumour Cell Machinery,FP7,,,100000.0 MEMSFORLIFE,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"This proposal situated at the interfaces of the microengineering, biological and medical fields aims to develop microfluidic chips for studying living roundworms (Caenorhabditis elegans), living cultured liver tissue slices obtained from mice, and formaldehyde/paraffin-fixed human breast cancer tissue slices and tumors. Each type of microfluidic chip will be the central component of a computer-controlled platform having syringe pumps for accurate dosing of reagents and allowing microscopic observation or other types of detection. From an application point-of-view the work is focused on five objectives: (i) Development of high-throughput worm chips. Our goal is to build worm tools that enable high-throughput lifespan and behavioral measurements at single-animal resolution with statistical relevance. (ii) Linking on-chip microparticles (beads) to the C. elegans cuticle. We will use beads with electrostatic surface charges and beads that have a magnetic core for quantification of locomotion and forces developed by the worms. Moreover high-refractive index microspheres will be used as in situ microlenses for optical nanoscopic worm imaging. (iii) Realization of a nanocalorimetric chip-based setup to determine the minute amount of heat produced by worms and comparison of the metabolic activity of wild-type worms and mutants. (iv) Study of precision-cut ex vivo liver tissue slices from mice, in particular to evaluate glucose synthesis. The slices will be perifused with nutrients and oxygen in a continuous way and glucose detection will be based on the electrochemical principle using microfabricated electrodes. (v) On-chip immunohistochemical processing and fluorescent imaging of fixed clinical tissue slices and tumorectomy samples. These systems aim the multiplexed detection of biomarkers on cancerous tissues for fast and accurate clinical diagnosis.",Microfluidic systems for the study of living roundworms (Caenorhabditis elegans) and tissues,FP7,30 April 2018,01 May 2013,2492400.0 MEMTIDE,Imperial College London,health,"The MemTide Initial Training Network will create a new generation of synthesis technologies for peptide and oligonucleotide ('tide') manufacture, with focus on the use of emerging membrane technology to effect critical separations. New nanofiltration membranes with improved chemical stability, and closely controlled molecular discrimination properties, will be developed. Novel synthesis strategies for tides, which utilise membranes for key separations will be created. MemTide will consider both step change improvements to solid phase tide synthesis, and the realisation of a completely new concept of tide synthesis based on solution phase synthesis coupled to membrane purification. The applications of these technologies will be through the industrial partners. The project is multidisciplinary, involving chemists, materials scientists and chemical engineers. The consortium is intersectorial, comprising 3 universities/research institutes, a technology SME, a fine chemicals company and a large pharmaceutical manufacturer, and will have a strong emphasis on knowledge creation, technology commercialisation, and entrepreneurship. The training programme involves Early Stage Researchers (ESR), at both university and industrial partners, each of whom will complete a PhD thesis through a combination of local and network wide research experience. Experienced Researchers (ER) will complete their training through development of entrepreneurship and project management skills. ESR and ER will complete complementary training through a series of Personal Skills Modules, and a course on Technology Commercialisation and Entrepreurship. MemTide seeks to contribute to improving the European knowledge supply chain through this industry-academia programme aimed at developing engineers and scientists who are academically excellent and achieve PhD degrees, but who thrive at the interface between fundamental research and industrial application.",Membrane Enhanced Tide Synthesis - A New Paradigm Peptide / Oligonucleotide Synthesis Technology,FP7,30 November 2013,01 December 2009,2329000.0 MENCOFINAS,University of York,health,"Magnetic energy conversion using nanoparticles is fundamental to many rapidly developing areas such as environment-friendly nanotechnologies or in biomedicine. Examples include the use of magnetic nanoparticles (MPs) in devices for magnetocaloric refrigeration or for heating in the hyperthermia treatment of cancer. Investing in these areas is imperative if the European Research Area and the European nanotechnologies industry it to gain a worldwide leadership. Essential are scientific developments and also professional training of researchers to provide them with skills in fundamental physics and applied technology aspects. The present proposal's aim in this direction is the career development of Dr. Hovorka combined with the enhancement of his scientific expertise in the field of MP systems. Despite their importance for applications, superparamagnetic and ferromagnetic MP mixtures have been poorly studied and, as a result, the effects of interactions and hysteresis on energy losses and heat generation can presently be analyzed only on the empirical level. The aim here is to develop a solid theoretical understanding of these issues by employing the state-of-the-art multi-scale and atomistic modeling approaches as well as large scale Monte-Carlo methods. The research will be carried out at the host University of York (UK) and benefit from the top-class computational research facilities and the long standing scientific and industrial experience of Prof. Chantrell, who is the world leading scientific contributor in the field. The inter-disciplinary expertise gained during the program as well as new perspectives gathered through the transnational mobility, will put Dr. Hovorka into an excellent position to build an entirely new research portfolio and to effectively interface with leading industry researchers and developers in the future. This will strengthen the European excellence and competitiveness in the research field of applied and fundamental nano-magnetism.",Magnetic Energy Conversion in Fine Nanoparticle Systems,FP7,31 July 2013,01 August 2011,209592.0 MENUG,Foundation for Research & Technology Hellas (FORTH),health,"Genetic diseases can only be truly cured via restoration of defective gene function. Homologous recombination is the ultimate tool for gene replacement, but is limited by low efficiency and reproducibility. DNA double-strand breaks enhance the efficiency of homologous recombination in vitro dramatically, however for in vivo applications absolute site-specificity is crucial. Engineered, highly specific DNA endonucleases (???meganucleases???) with programmable specificity are the key to a wider use of homologous recombination in gene replacement. MenuG seeks to develop meganucleases that cleave only at positions of interest in a genomic context with the aim to solve - based on homologous recombination - the main problem in gene therapy: to replace genes efficiently, selectively and reproducibly. Three types of meganucleases will be engineered: (i) programmed restriction enzymes, (ii) novel or redesigned homing endonucleases, (iii) redesigned Type IIS restriction enzymes. These will be tested for in vitro cleavage specificity, delivery into the nuclei, in vivo cleavage specificity and induction of double-strand break repair by homologous recombination. Promising meganucleases will be tested for gene replacement in Pompe metabolic disease. Concepts for commercial applications will be developed. MenuG is a high risk project, starting from the engineering of programmable meganucleases to efficient cell delivery and specific action on a defined genetic locus. It has a high impact profile with potentially enormous benefits primarily in the treatment of inherited monogenetic diseases, but in principle also of multigenic disorders, including cancer. Its innovative and visionary concepts are in the spirit of ADVENTURE. MenuG is multidisciplinary (comprising biochemistry, molecular, structural and cell biology, medicine, biotechnology, nanotechnology); its truly ambitious goals can only be achieved at a European level by pooling expertise from academic and industrial units.",Meganucleases for Gene Replacement,FP6,14 November 2009,15 May 2006,1715163.0 MEPHISTO,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,information and communications technology,"The overall aim of MEPHISTO is to develop a silicon-on-insulator (SOI) based hybrid integration platform ('optical motherboard', OMB) for implementing optical subsystems encompassing optical, optoelectronic and electronic functions. Such a comprehensive hybridised integration will be a key technology to meet the demands of increasing compactness and complexity, mass production, cost reduction, and reliability of future optical components to be used in photonic networks, but also for other emerging areas like sensor and microsystems technologies, and in particular optical interconnects in high-speed VLSI electronics. It is unlikely that in the foreseeable future such complex integrated subsystems will rely on a fully monolithic integration approach due to inherent drawbacks with respect to overall performance and yield. SOI material will be employed as integration platform because it offers a number of distinct advantages over competing materials (silica-on-silicon, polymers or silicon-oxynitride), both technically and economically. Compared to previous developments in this field the target of the MEPHISTO project takes the concepts of optical motherboards much further, involving the hybridisation of the active III-V components with sophisticated silicon optical circuits which will comprise arrayed waveguide gratings (AWG) and variable optical attenuators (VOA), and the integration of Si VLSI electronics. More specifically, the goals of MEPHISTO are to study and develop crucial, innovative enabling technologies and building blocks for realizing advanced SOI based OMB subsystems. These will be used in particular to implement 'proof-of-concept' integrated dense wavelength division multiplexing (DWDM) transmitter components for C-band wavelength (1535-1565 nm) operation incorporating complex optical, optoelectronic, and electronic functions. The practicability, the issues and challenges involved in the SOI based optical motherboard technology will be assessed.",Merger of Electronics and Photonics Using Silicon Based Technologies,FP6,31 December 2008,31 July 2004,2099966.0 MEQUANO,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"We propose innovative approaches to electronic quantum noise going from very fundamental topics addressing the quantum statistics of few electrons transferred through conductors to direct applications with the realization of new types of versatile broadband photon detectors based on photon-assisted shot noise. We will develop electron counting tools which will not only allow to full characterization of electron statistics but also open the way to new quantum interference experiments involving few electrons or fractional charge carriers and will question our understanding of quantum statistics. Generation of few electron bunches will be obtained by the yet never done technique of short voltage pulses whose duration is limited to few action quanta, one quantum for one electron. Detection of electron bunches will be done by an unprecedented technique of cut and probe where carriers are suddenly isolated in the circuit for further sensitive charge detection. Using highly ballistic electron nanostructures such as Graphene, III-V semiconductors with light carriers, Carbone Nanotubes or simply tunnel barriers, we will bring mesoscopic quantum noise effects to higher temperature, energy and frequency range, and thus closer to applications. Inspired by late R. Landauer s saying: the noise IS the signal we will develop totally new detectors based on the universal effect of photon-assisted electron shot noise. These versatile broadband detectors will be used either for on-chip noise detection or for photon radiation detection, possibly including imaging. They will operate above liquid Helium temperature and at THz frequencies although projected operation includes room temperature and far-infrared range as no fundamental limitation is expected. The complete program, balanced between very fundamental quantum issues and applications of quantum effects, will open routes for new quantum investigations and offer to a broad community new applications of mesoscopic effects.",Mesoscopic Quantum Noise: from few electron statistics to shot noise based photon detection,FP7,01 July 2017,02 January 2009,1999843.44 MERCURE,Thales SA,information and communications technology,"The ENIAC JU project MERCURE is developing advanced semiconductor materials to provide functionality not available before with silicon-based micro- or nanoelectronics. It will enable future ambient intelligence systems to achieve autonomous and self-reconfigurable operations with real-time and efficient self-optimisation of performance. Key applications will include the future wireless communications market which will expand to higher frequencies as new applications and frequency bands are allocated. This will require an always-connected, multi-standard, multi-service communications environment.",Micro and Nano Technologies Based on Wide Band Gap Materials for Future Transmitting Receiving and Sensing Systems,FP7,01 January 2013,02 January 2010,550714.0 MERGING,ICN2 - Institut Català de Nanociència i Nanotecnologia,energy,"The aim of this proposal is to realise a compact thermoelectric module to harvest the energy of devices to be used in applications requiring heterogeneous integration packaging techniques leading to small size, integrability and high thermoelectric efficiency. Our concept, which goes up to a test device, is based on deep understanding of the behaviour of phonons, their control leading to the control of thermal transport. It is based on minimizing the thermal conductance and or thermal conductivity by phonon engineering. A ZT=2.5 is targeted together with module compactness and integration potential. The module will be based on technologies combining Si microelectronics, thin film thermoelectric material and novel concepts to understand heat transport in 2-dimensional (2D) nanostructured materials such as Si-based ultrathin membranes, GeMn and strontium titanate. The device will carry enough current but insignificant or little heat. Theoretical and experimental investigations of heat transport will be carried out. The methods and technologies developed will enable nm-scale control of energy generation and heat flow. This will impact on on-chip and in-package energy management that is of crucial importance for future technologies. Especially, our targets contribute to (a) on-chip harvesting of thermoelectricity and (b) management of heat flow in the applications of heterogeneous integration and nanoelectronics.",Membrane-based phononic engineering for energy harvesting,FP7,31 December 2015,01 January 2013,2849654.0 MERIDIAN,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,health,"The main goal of this proposal is to bring novel technology of biocompatible, low bio-fouling, high electrochemical performance carbon nanomaterials to in-vivo preclinical applications and at the same time to use this materials to develop a highly advanced concept of intimate intracellular contact, based on bottom - up technology of, engulfing the micro-electrode by neural cells. Such bionic interfaces resemble true intrinsic physiological properties of neural somas and form a tight, extremely low-invasive bidirectional coupling for both motor and sensory functions. Advantage of our approach is unperfected fidelity of signals and resolution of single neuron fibers to be coupled to one protruding electrode. The research targets are devices ranging from cuff or lead electrodes to novel bidirectional interfaces for both sensory and motor functions for cybernetic mind-controlled prosthetics. Instead of re-targeting to an entire muscle, our research comes thus with a technique how to couple neurons by an intracellular way to form a single microelectrode-axon stimulating device and at the same time to provide sensory input, being on the front edge of research on bionic interfaces for novel neuroprosthetics. The proposed technology takes advantage of unique properties of well established nanodiamond thin films, with their unique and the simple carbon chemistry allowing integration with antibactericidal and anti-inflammatory surfaces. MERIDIAN will demonstrate devices in in-vivo studies and in preclinical tests on humans and benchmark fabricated devices with the current state of the art bionic system on the market.",Micro and Nano Engineered Bi-Directional Carbon Interfaces for Advanced Peripheral Nervous System Prosthetics and Hybrid Bionics,FP7,28 February 2015,01 March 2012,3780000.0 MERMIG,Polytechnic University of Valencia * Universitat Politècnica de València,manufacturing,"Space system vendors seek for solutions to deliver small size and cost-effective sensor systems to 'de-congest' satellite payloads, drastically reduce the equipment cost and open the possibility for new generation of micro-payload systems. MERMIG aims to provide this technology replacing current expensive, bulky, heavy and power-consuming fiber optic gyroscopes (FOGs). To address these key challenges, MERMIG invests in the right mix of silicon photonic CMOS-compatible component fabrication and nano-imprint lithography laser fabrication. Both technologies are being adopted by the terrestrial telecom market and MERMIG will develop them for bringing their unique advantages into space sensor systems. MERMIG will squeeze the bulky FOG into a couple of cm2, integrating a racetrack cavity, pin junctions and a phase decoder into compact sub-micron waveguides. The MERMIG 'smart' packaging technique will allow power-efficient optical pumping and hermetic packaging of the gyro-photonic chip. MERMIG will develop the first 1550nm high-power laser with a fiber-coupled power of 150mW using an integrated laser MOPA, fabricated with advanced nano-imprint lithography (NIL). The 150mW delivered will enable a modular architecture, with pump sharing among 3 integrated silicon lasing cavities, for 3-axis sensing. The single-step NIL process enables fast wafer scale patterning and ensures low-cost and high-volume laser production. Finally, MERMIG will bring together photonics and electronics on a fully-functional opto-electronic gyroscope system prototype characterized according to ASTRIUM testplan procedures. MERMIG will deliver to ASTRIUM a new generation gyroscope that will weigh <1kg, consume <5W electrical power in a few cm3 footprint. The angle random walk range that will be feasible within MERMIG is 0.1 -0.01 deg/sqrt(hr) suitable for telecommunications and scientific satellites. The technology full potential can allow for future opto-electronic integration of photonic 'gyroscopes-on-a-chip'.",Modular CMOS Photonic Integrated Micro-Gyroscope,FP7,31 October 2015,01 November 2012,1495364.0 MESCD,University of Antwerp * Universiteit Antwerpen,information and communications technology,"The mechanical properties of graphene, the thinnest material in the world, will be investigated theoretically. This project will focus on the basic and advanced mechanical properties that are potentially useful for controlling: i) the strain distribution, ii) the band gap, and iii) the observation and visualization of electronic polarization in single/multilayer graphene. The theoretical","Tuning of the mechanical and electronic properties of graphene by strain, chemical doping and defects",FP7,07 May 2016,07 June 2014,0.0 MESO-IMPLANT,Imperial College London,health,"The MESO-IMPLANT project was inspired by the most recent achievements in nanotechnology and regenerative medicine and has two major objectives. The first one is based on the original idea of using the thin films of ordered mesoporous materials as coatings for bone implants. Such coatings have extremely high specific surface areas and pore volumes and are aimed to significantly improve the speed of bone formation on their surface. This would allow to lower the implant fixation time and to lower the probability of implant failure. The applicant will synthesize ordered mesoporous thin films of various metal oxides (eg. titania, alumina) and test how they can improve bone formation. The latter will be performed by direct contact of such layers with bone forming cells (osteoblasts) and observation of their bone forming activity (eg. under optical microscope). Additionally, the mesopore system will be functionalized with bioactive molecules which can mediate osteoblast adhesion process as well as to control the differentiation of the adult stem cells. Successful results of this project may open new research areas both in academia and in industry. The second aim of this project is to give the high-end interdisciplinary training-through-research in nanobiotechnology and nanomedice to the applicant. His background is chemistry and nanomaterials and through this project he will have an unrivalled opportunity to develop his skills in bionanotechnology with help of the leading scientists in the filed. Moreover, he will have a chance to work in the highly multidisciplinary environment at one of the top universities in the world.",Nanostructured Mesoporous Coatings of Implant Materials for Improved Bone Formation,FP7,30 November 2010,01 December 2008,168823.0 MESOCAT,University of Central Lancashire (UCLAN),environment,"This proposal is for an IIF award to enable a researcher from India to visit a laboratory in the UK and develop: (i) new scientific skills; (ii) a lasting collaboration within the UK; and (iii) potential to increase the research capacity of his home research environment.The science of the proposal aims at understanding chemical mechanisms and catalyst design factors that influence degradation of selected pesticides by particle photocatalysts in aqueous solution. This understanding will be used to design & synthesise more efficient TiO2 photocatalysts for the destruction of priority organic pollutants.The latter will be achieved using nanoparticle production technologies to synthesize surface & composition modified catalysts. For modification of composition, we propose to produce innovative P25 analogues - in particular, to control the rutile crystallite size, anatase porocity and anatase/rutile ratio and to optimize the reactivity of the catalyst with respect to those parameters. For modification of the surface, we propose to conduct a novel study of the efficiencies of photodegradation of hydro-phobic/philic pesticides on samples of TiO2 that have been pretreated to render their surfaces highly hydrophilic & highly hydrophobic, so allowing assessment of the respective efficiencies of dynamic & static photodegradation mechanisms for each class of pollutant. We also propose to use the Quartz Crystal Microbalance to measure substrate adsorption at the catalyst surface in real time and most especially during a photodegradation experiment.The intermediates & mechanism through which the pesticides of interests are destroyed by these modified photocatalysts will also be investigated. Experiments will be conducted to map the A->B->C etc degradation route of each pollutant and to study how competition effects influence this process. To prevent adverse environmental impact, toxicity of photodegradation intermediates will be assessed and compared with the parent molecule.",Mesoporous Photocatalysts for the Degradation of Persistent Organic Pollutants,FP6,17 July 2009,18 July 2006,229327.32 MESOLIGHT,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"Research will focus on the generation of electric power by mesoscopic solar cells, a domain where the PI has an outstanding track record and leadership on the global scale. The target is to increase the photovoltaic conversion efficiency from currently 11 to over 15 percent rendering these new solar cells very attractive for applications in large areas of photovoltaic electricity production. The approach to reach this challenging target is highly creative and has a strongly interdisciplinary character. Successful implementation of the project goals is assured by the vast experience and know how of the PI and his team in the key areas of the project. The project is divided in four work packages. The first three introduce creative new concepts to enhance substantially the performance of single-junction dye sensitized nanocrystalline devices, while the fourth addresses multi-junction cells and photon up-conversion systems. The tasks to be accomplished comprise 1) The theoretically assisted conception and synthesis of new molecular sensitizers to extend the spectral response of dye sensitized photovoltaic cells into the near IR up to 900 nm, increasing substantially the short circuit photocurrent of the solar cell. 2) The implementation of highly innovative mesoscopic oxides structures to support the molecular dye or quantum dot and collect the photo-generated charge carriers. 3) The introduction of smart amphiphilic molecular insulators and ultra-thin ceramic barriers at the mesoscopic junction in order to retard the interfacial electron-hole recombination and 4) The exploration of radically new cell embodiments based on multi-junction tandem cells and photon up-conversion schemes, whose solar to electric power conversion efficiency can be raised beyond the Shockley-Queiser limit of 32 percent.",Mesoscopic Junctions for Light Energy Harvesting and Conversion,FP7,28 February 2015,01 March 2010,2046000.0 MESOMAGSTRUCT,University of Cambridge,information and communications technology,"The research and development of Magnetic Random Access Memory (MRAM) and magnetic logic devices is of keen interest to the computer industry. The development of computers with high density, fast access times, non-volatility and low power consumption will undoubtedly affect many different sectors of society including business and media, aeronautics and space technology, security and the defense industry. Computers have become an integral part of our everyday lives and we are becoming increasingly reliant on them to storeimportant information. Recent advances in materials processing technology and nanotechnology have opened up new lines of research involving spin electronics. This project proposes the investigation of novel ferromagnetic nanopatterned ring structures, which display a fascinating range of magnetisation states and can be probed using magnetoresistance. These mesoscopic structures can be engineered to display different stable magnetised states depending on their shape, dimensions, and composition. An understanding of the stability of different states, and the ability to control the switching field, enables nanomagnets to find application in patterned media, in whicheach uniaxial element stores one bit of data, high-density magnetic random access memory (MRAMs), magnetic logic and other magnetoelectronic devices, such as spin-filters and spin-transistors. The successful development of this design will have a significant impact on the European computer and electronics industries, as well as advancing our current understanding of magnetic and electrical materials on the micron and nanoscale. This project contributes to several European priority areas including: information society technologies, nanotechnology, nanoelectronics, new production processes and devices.European laboratories have an outstanding strength in basic science and technology. Europe is in a good position to take the current research in magnetic and electrical materials and develop#",NOVEL FERROMAGNETIC RING STRUCTURES FOR DEVICE APPLICATIONS,FP6,30 April 2007,01 May 2004,254389.0 MESOPLAS,Autonomous University of Madrid * Universidad Autónoma de Madrid,photonics,"The boost experienced by nanophotonics research during the past decade has been driven by the ability of surface plasmons to collect and concentrate light into deeply sub-wavelength volumes. The hybrid nature of surface plasmons (which emerge from the coupling of photons to the collective oscillations of conduction electrons in metals) has allowed an unprecedented control of light at the nanoscale, a regime inaccessible to standard photonic technology. This scientific success has been possible due to two factors: the high precision of modern nanofabrication and characterization techniques, and the extraordinary predictive value of classical electrodynamics. However, the miniaturization trend in experimental nano-optics is currently approaching dimensions comparable to the typical Coulomb screening length in noble metals (of the order of a few angstroms). A theoretical challenge arises in this spatial range for two reasons. On the one hand, at this sub-nanometre regime, macroscopic electromagnetism breaks down due to the emergence of quantum effects such as spatial non-locality. On the other hand, the enormous complexity of the full quantum numerical schemes available to describe the electron-ion dynamics in metals restricts their applicability to systems involving only a few hundreds of electrons. The objective of this proposal is to fill the gap between Maxwell's equations and first principle condensed matter theory methods. It aims to devise a mesoscopic platform able to treat accurately and efficiently the interaction between light and matter in nanodevices which, presenting angstrom-sized geometric features, contain millions of electrons. This is a prominent fundamental problem with significant technological implications. The further development of nanophotonic technology requires a complete and unified picture of the physical mechanisms behind its performance. The ultimate goal of this proposal is providing the theoretical framework for this purpose.",Mesoscopic Plasmonics: Bridging Classical and Quantum Nano-Optics,FP7,,,100000.0 MESOPOMS,University of Crete * Panepistimio Kritis,photonics,"The synthesis of nanostructured mesoporous polyoxometalates with high internal surface area and ordered or/and hierarchical pore structure remains an open challenge. This proposal aims to the development of such nanostructures. On one hand mesoporous materials with well-defined pore structure and high internal surface area are of great scientific and technological interest because of the possibility of tailoring their pore structure and framework composition. On the other hand metal-oxygen cluster anions of the early transition metals, commonly referred to as polyoxometalates and transition metal-substituted polyoxometalates, are important supramolecular inorganic nanoclusters with wide range of chemical structures and physicochemical properties and, thus attractive for applications such as photocatalysts, redox catalysts, electrochemical sensors and magnetic and optoelectronic devices. It would be very interesting to combine the shape selectivity of a mesoporous solid with the catalytic, optoelectronic and magnetic properties of a polyoxometalate cluster. Polyoxometalate clusters can provide novel building blocks, when they became nanostructured, promising new type of multifunctional nanomaterials We intend to establish new synthetic strategies toward nanostructured polyoxometalate-based mesoporous materials with well-defined pore structure and high internal surface area. For example purely inorganic and organic-supported nanostructured POM-based materials such as SiO2-, TiO2-, Al2O3-, SnO2-POM and {Q}-POM (where (POM= [(Mn,Ni)Mo9O32]6-, [(Co,Zn)PW11O39]5-, [(Eu)W10O36]9- and Q= 4,4-bipyridine, [Ag2(CH3CN)4]2+, (R'O)3SiRSi(OR')3) will be explored. Integration of these POM nanostructures in thin film morphology will also be attempted. The resulted mesoporous polyoxometalates are expected of considerable performance in catalytic applications in reduction-oxidation of pollutant NOx and SOx gases and in epoxidation/oxidation of alkanes and alkenes.",Nanostructured Mesoporous Polyoxometalate and Transition Metal-substituted Polyoxometalate Materials: Applications in Heterogeneous Catalysis,FP7,31 August 2012,01 September 2008,100000.0 MESOQMC,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"Understanding electronic correlations remains one of the biggest challenges of theoretical condensed matter physics. Mesoscopic systems, where electronic confinement can be externally controlled, are natural test beds for understanding the effects of correlations, and the lack of proper techniques to take them into account is acute. This project aims at developing new tools for simulating correlated quantum mesoscopic devices. We will combine standard approaches for transport in mesoscopic quantum systems with new quantum Monte-Carlo algorithms designed to capture correlations in those devices. We will use modern programming paradigms to develop a versatile numerical platform designed to be easily used by other research groups. These numerical tools will be closely related to existing analytical approaches so that we shall be able to make contact with standard many-body theory while go beyond the limitations of the analytical approaches. We will apply this new set of techniques to several problems that have been puzzling the community for some time including quantum transport in low-density two-dimensional gases for both bulk disordered systems (“Two dimensional metal-insulator transition”) and quantum point contacts (“0.7 anomaly”). We will also apply our techniques to several new problems of increasing importance: at finite-frequency, electron-electron interactions play a central role and must be taken into account properly. We will discuss high frequency measurements such as quantum capacitances, ac conductance or photo-assisted transport in a variety of materials (twodimensional gases of electrons or holes, graphene, semi-conductor nanowires…) and leverage on our new numerical tools to go beyond the standard mean field description.",Quantum Monte-Carlo in mesoscopic devices,FP7,12 July 2017,01 January 2011,1222176.0 MESOTAS,Universiteit Twente * Twente University,health,"Laboratory-on-a-Chip technology was introduced in this field. To avoid the complexity of an animal model and to reduce the number of animals for pre-clinical research cell culture models are important. Here, the combination of microfluidics, tissue engineering and neuroelectrophysiology on MEA-chips is suggested. Because neuronal tissue on chip may act differently from the neurons in their natural environment, the first objective is to follow a systems engineering approach to realize a platform technology, which allows us to reliably co-culture cells in a 3D interconnected configuration, providing an artificially vascularized system on a MEA. For on-line monitoring of the culturing conditions, we will implement micro-total analysis systems (TAS) technology proposing microchip capillary electrophoresis, potentially coupled to mass spectrometry, to correlate electrophysiology with neurochemistry. Previously, it has been demonstrated that physical and chemical micro- and nanostructures influence cell guidance, viability and cell differentiation, so far, unfortunately without a unifying theory to explain the involved mechanisms. Therefore, our second objective is to further our understanding with respect to the influence of nanocues, implementing microfluidic programming to activate porous nanostructures on MEA and investigate cellular signaling and pathway reactions related to the cell's adhesion mechanism. Combining the first and the second objective will allow us to work towards clinical questions of neurodynamic diseases as epilepsy, characterized by intermittent abnormal synchronization of different neuronal populations. We hypothesize that for these disorders, 3D cell co-culture models will resemble the natural neural networks more closely than 2D, which may subsequently serve as a model to study novel therapeutic procedures, for instance selective neurostimulation. Thus, we propose, as our third objective, nanostimulation of neuronal subsystem.","Chatting with Neurons: A novel approach to the study of neurophysiologic responses of neuronal tissue in vitro, combining nanotechnology, tissue engineering, microfluidics and neuroelectrophysiology",FP7,30 September 2016,01 October 2011,1260000.0 META,University of Comenius in Bratislava * Univerzita Komenského v Bratislave,health,"META (Materials Enhancement for Tecnological Applications) aims to address the fundamental new challenges related to the development of new functionally structured materials and to gain a deep understanding of the structure and dynamics of nanostructured matter on multiple length and time scales. Basic science investigation will be driven by the accomplishment of technology development for nanodevices through experimental and theoretical interdisciplinary studies, aimed at endowing materials with specific local properties. Two types of devices will be investigated: DNA planar architectures exploitable as 'mother boards' for self-assemblage of functional components to build functional nanodevices at negligible production cost and devices based on interface-enhanced charge conductivity where the understanding of the interplay on a nanometric scale between ionic conductivity and local physico-chemical properties will be exploited for the development of micro Solid Oxide Fuel Cells (μSOFCs). META goal is to establish a strong collaborative network between research centres in the EU (Italy, Slovakia) and in the USA. Such collaboration is addressed to tackle the variety of scientific and technological issues raised by enhancement and engineering of materials functional properties both at the nano and meso scale. Several bilateral visits, training workshops and meetings are planned with the framework of the project. Education will also be an important issue in this project, since exchange of graduate students and the opportunity of creating a joint PhD initiative is programmed. META will thus amplify the collaborative links between the EU and the USA giving European Scientists the opportunity of achieving rapid access to world top laboratories. The project meetings and conferences will attract scientists from other universities and industrial companies which would be highly beneficial for the present partner institutions and ERA in whole.",Materials Enhancement for Technological Applications,FP7,31 May 2015,01 June 2011,403200.0 METACHEM,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"The objective of the METACHEM collaborative project is to use the extreme versatility of nano-chemistry to design and manufacture bulk meta-materials exhibiting non-conventional electromagnetic properties in the range of visible light. This spectral domain requires nano-scale patterns, typically around 50 nm in size or less. Our strategy consists in designing and synthesizing ad-hoc nano particles as optical plasmonic nano-resonators and organising them through self-assembly methods in 2 or 3 dimensional networks in order to produce dense highly ordered structures at a nano-scale level. Several subprojects corresponding to different routes are proposed, all of them based on existing state-of-the-art chemical and self assembly methods. In addition, the important issue of losses inherent to the plasmonic response of the nano-objects is addressed in an original way by the adjunction of loss-compensating active gain media. A special effort is made on the difficult measurement of the non conventional meta-properties as they constitute the first demonstration of the validity of the concept. A technological and an industrial point are added towards the search of efficient, cost-effective and industrially feasible metamaterials. The key point of the METACHEM project joining 9 partners from 7 European states is that it brings together for the first time European experts of three complementary fields namely nanochemistry, self-assembly methods and metamaterials science. The majority of the partners are members of FP7 virtual institutes related to these fields i.e. respectively EMMI, SOFTCOMP and METAMORPHOSE II. Main goals: Design and synthesize optically isotropic meta-materials with exotic and extreme properties realized by simple and cheap chemical methods. Target properties: artificial optical magnetic and dielectric properties, optical left-handed materials, near-zero permittivity/permeability; negative index materials, low-loss plasmonic structures.",Nanochemistry and self-assembly routes to metamaterials for visible light,FP7,14 September 2013,15 September 2009,3699990.0 METAMORPHOSE,Aalto University * Aalto-yliopisto,photonics,"The main scientific objective of this Network is to develop new types of artificial materials, called metamaterials, with electromagnetic properties that cannot be found among natural materials. The results of this development should lead to a conceptually new range of radio, microwave, and optical technologies, based on revolutionary new materials made by large-scale assembly of some basic elements (microscopic and nanoscopic) in unprecedented combinations. These artificial electromagnetic functional materials are engineered to satisfy the prescribed requirements. Joint research activities of this Network will include composite materials with extreme electromagnetic properties (such as 'left-handed' media and materials with null-valued effective parameters), electrically controllable materials, stop band materials, metageometries like fractals and quasi-periodical structures, artificial surfaces and sheets. The strategic objective to develop new metamaterials means opening a new branch of research in the multidisciplinary field of material physics, electromagnetics, optics, radio engineering, and electronics. The Network activities should result in: Common European research platform and mature scientific community; Integrated Projects in strategically targeted areas; A new international PhD program; Web-based learning tools and an information platform; Established mechanism for common use of research facilities; Established regular scientific conferences and workshops. The Metamorphose initiative integrates 13 different countries around Europe from North (FIN, S) to South (E, I, GR, TR) and from East (PL, RUS) to West (UK, B) passing through its centre (F, D, CH). In all these countries, very advanced technological facilities have been developed (computing centres, nano-electronic facilities, high frequency characterization of materials), all of them being of prime importance in the lasting integration of the Metamorphose #","MetaMaterials ORganized for radio, millimeter wave, and PHOtonic Superlattice Engineering",FP6,31 May 2008,01 June 2004,4400000.0 METAMOS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"Among the main difficulties to overcome toward the 10 nm gate length MOSFET, many challenges are associated to the source/drain (S/D) regions. The tight constraints of dopant activation to achieve very highly doped junctions, extremely steep lateral profiling, low contact specific resistance have motivated a renewed interest in MOSFETs architectures that integrate metallic Schottky S/D. Based on that background, the METAMOS project proposes the design, optimisation, fabrication and characterization of metallic Schottky-Barrier-like MOSFETs to solve critical problems associated to the source/drain architecture and more specifically due to the specific contact resistance at the metal (or silicide) to silicon interface. The first major objective is to develop and fully characterize advanced very low Schottky barriers (<0.1 eV) primiraly based on (but not limited to) silicides of platinum and iridium for p-type contacts and rare earth silicides (erbium, ytterbium) for n-type contacts. The second objective is to demonstrate the complete integration of metallic source/drain (S/D) in a complementary MOS technology at academic level as a test bed to operate the appropriate selection of contact materials and process flow for industrial exploitation. The third objective concentrates on the implementation of metallic S/D into bulk and SOI CMOS process cores to demonstrate the transfer from a laboratory concept to an industrially viable solution. Finally, the fourth general objective is to get a definitive answer on the ability of metallic S/D MOSFETs and of non-overlap architectures to outmatch the conventional one, based on device demonstration, wideband measurements, physical modelling and comparison with CMOS state-of-the-art and ITRS requirements. To reach this goal, the project is organized in 4 technical workpackages covering i) material engineering, ii) process integration, iii) device simulation and modeling and iv) material and device characterization.",Metallic source and drain for advanced MOS technology,FP6,31 December 2008,31 August 2005,2259691.0 METATUNE,Imperial College London,photonics,"A metamaterial is a material which gains its properties from its structure rather than directly from its materials composition. Within the context of photonics, such compounds are engineered composites that exhibit superior, designed properties that are not found in nature and not observed in the constituent materials. They have demonstrated many intriguing properties and applications for control over electromagnetic waves such as negative refraction, superlensing, and cloaking devices. Metamaterials have the potential to develop into a highly disruptive technology over the whole electromagnetic spectrum, ranging from more efficient radiofrequency antennas to the marriage of nanoscience and photonics for a whole new generation of optoelectronic devices. Since the first studies on negative-index metamaterials, the attention of most researchers has been focused on the passive control and linear properties of these composite structures, where the effective parameters of the structure do not depend on the intensity of the applied field or propagating electromagnetic waves. However, to achieve the full potential of the unique properties of the metamaterials requires the ability to dynamically control the material's properties in real time through either direct external tuning or nonlinear responses.",TUNABLE NONLINEAR METAMATERIALS,FP7,31 March 2012,01 April 2010,180603.0 METROCOMB,M Squared Lasers Ltd.,health,"The research necessary to extend the application areas of femtosecond frequency combs through the development of compact, robust, low-cost, commercially-exploitable sources is now possible; taking advantage of the fact that ultrafast laser pulses of femtosecond widths, separated by nanoseconds, manifest themselves as a phase-coherent comb of frequencies spread over a wide spectral band. Furthermore, the development of femtosecond frequency combs in the infrared region of the electromagnetic spectrum and beyond offers enormous opportunities for exploitation in broad spectrum detection and metrology. Robust industrial laser sources such as those produced by the SME supply chain grouping brought together in this proposal can be used by the leading research groups in this consortium to develop frequency comb based spectroscopy systems offering unprecedented detection sensitivity and measurement accuracy. Moreover, if the wavelength range of the comb sources can be extended to cover the mid-IR region then such a source would be ideal for coherent Fourier-transform spectroscopy in the absorption-rich mid-IR 'molecular fingerprint' region delivering real-time acquisition of molecular spectra and real-time imaging with chemical identification for applications in large fast-growing global markets including environmental monitoring, real-time analysis of chemical /bio threats and explosives, trace molecular detection, and medical breath analysis. The project will be led by the SME group coordinated by M-Squared Lasers and produce IP which can be exploited across the supply chain covering optics, crystals, lasers and OPOs.",Femtosecond comb optical parametric oscillators for high-resolution spectroscopy in the mid-infrared,FP7,31 July 2015,01 August 2013,1499000.0 METROSURF,NPL Management Ltd.,information and communications technology,"The project investigates the development of original methods and algorithms for the dimensional and geometric verification of products and/or surface features defined at micro and nanometric scales. The idea is to overcome the current limitations of SEM imaging (only qualitative information) and micro/nano CMMs (slow, difficult to use) through an unconventional use of measurement data produced by advanced 3D profilometers and microscopes, which are being currently adopted in surface metrology for areal surface texture assessment.",Dimensional micro and nanometrology using areal topography data produced by 3D surface metrology instruments,FP7,,,0.0 MF-RETROFIT,National Technical University of Athens,health,"The project aims to deal with the numerous requirements of facade panel retrofitting by developing a light-weight, durable, cost effective and high performance panel. Its layered structure allows for separate but also synergistic function regarding high thermal and acoustic insulation, excellent mechanical properties, up to standards flame retardancy and photocatalytic activity. Employing nanofillers such as CNTs, TiO2 and perlite nanoparticles and cellular nanofibers, will lead to reduction of facade panel weight and thickness by at least 40%. Furthermore, individual components have a definite environmental orientation, taking advantage of recycled materials and biomass foams, low energy and low toxicity processes. Finally, project viability and sustainability will be ensured by performing a Life Cycle Analysis in order to optimize individual processes. Hygrothermal behaviour and thermodynamics will also be simulated and modelled to ensure the high performance of the panel. The project's advancements will be 1. Customization possibilities: Apart from panel thickness which can be easily tuned, integrated encapsulated nano-PCMs will be tailored along the customer needs regarding temperature of phase change. 2. Easy and fast to install: It is calculated that 10m2 can be installed in less than 3 hours by 2 workers 3. High acoustic and thermal insulation: The three internal layers offer varying degrees of insulation, with an ultra-light aerogel middle layer boasting thermal coefficients lower than 0.012 W/mK, thus allowing insulating layers 3 to 4 times thinner than conventional ones. 4. Photocatalytic activity offering self cleaning and antimicrobial behaviour, virtue of the surface coating. In addition, the surface coating will also contribute to flame retardancy due to nanofillers. 5. Reduction in weight and volume by 40%, as a result of applying polymeric and light-weight materials reinforced by nanofillers, therefore improving the panel mechanical properties",Multifunctional facades of reduced thickness for fast and cost-effective retrofitting,FP7,28 February 2017,01 September 2013,3599998.0 MI-LAB-ON-CHIP,University of Liège * Université de Liège,health,"A new breed of PET-imaging radiopharmaceuticals originating from the proteomic research is about to emerge, addressing major health concerns such as cancer treatment follow-up. Radiopharmaceuticals involve nano-molar quantities of active ingredients, which make the current radio-synthetic methods and device mostly inadequate to produce them. The availability of instruments scaled down to dimensions matching these quantities will be a major breakthrough. The objective of this proposal is to develop the knowledge and technology required for the design of a radically new range of miniaturized instruments in order to implement multiple step radio-chemistry processes at the micro molar scale. The new platform will include a smart, single use lab-on-chip component, that integrates and combines micro-fluidic functions and specific chemical functions, in which the processes are carried out. Depending on the compound to be produced, the appropriate chip will be inserted into the instrument. This will provide considerable benefits in terms of compounds quality, exposure of the operators, operation costs, reduction of waste, securing Europe's endangered leadership in this field. This project integrates and translates knowledge and expertise in a number of fields such as biotechnology, pharmacy, synthetic chemistry, radiochemistry, micro-fluidics and micro-fabrication, electronic and electromechanical miniaturisation. The needed leading edge skills will be properly ensured by Trasis who is experienced in such translational developments and in the production of such systems. The complementarities of the partners, their skills and the multidisciplinary approach ensure high chances of success:3 SMEs and 3 research centers, 4 countries, specialized in design and manufacturing of tracer production instruments, PET radiochemistry, micro-fluidics design and fast micro-prototyping, micro-tech. simulation, micro-parts mass production and gluco-protein chemistry",Lab-on-a-chip implementation of production processes for new Molecular lmaging Agents,FP6,30 September 2008,01 October 2005,2100000.0 MIA-CP,The University of Edinburgh,health,"This proposal details the preparation of novel electromechanical polymers based on mechanically interlocked molecules. These synthetic muscle-like fibres would function via entirely new mechanisms of actuation and have potential applications in the medical, engineering and nanotechnology sectors. In general terms the overall project aim is to couple the latest catalytic mechanical bond-forming methodologies with recent advances in conjugated polymer synthesis to formulate a new generation high performance electromechanical materials. This multidisciplinary research programme integrates aspects of organic, supramolecular and physical chemistry together with materials science. The project objectives will be achieved via a three phase research programme that combines realistic project milestones with focused training activities in materials processing and analysis. The research would be carried out by a promising European scientist at MIT, USA under the supervision of Prof. Swager and at the University of Edinburgh, UK in the group of Prof. Leigh. The researcher's previous experience in organic/supramolecular chemistry and successful academic track record would be exploited during the initial phase of the project and then complemented by intensive training in polymer preparation, processing, analysis and electromechanical device testing. The advanced training provided by the outgoing host would then be applied during the reintegration period through mentoring and collaborative activities. Overall this research programme would facilitate scientific advances at the interface between molecular devices and materials science, foster collaboration between world leading groups in the US and Europe and would effectively bridge the gap between the researchers current position as a skilled research scientist and a position of complete academic independence and professional maturity.",Mechanically Interlocked Actuating Conjugated Polymers,FP7,31 July 2012,01 August 2009,237595.0 MICREAGENTS,Ruhr University Bochum * Ruhr-Universität Bochum,health,"The goal of the project is to give electronics and chemistry an equal autonomous say in programming complex chemical constructions, processes and analyses at the nano and microscales: the same scale where information processing in living systems occurs -where 'to construct is to compute'. To do this MICREAgents (MIcroscopic Chemically Reactive Electronic Agents) will develop novel electronically active microreactor components, called lablets, that self-assemble at a scale less than 100 µm, approaching that of living cells. The project will integrate the necessary components to ensure autonomous action of millions of these 'very smart chemicals', including electronic logic, supercapacitors for power, pairwise coupling for communication, programmable chemical sensors and electronic actuation of chemical processing. Key examples of MICREAgent actuation are to reversibly switch their association, load or dose chemicals, modify surfaces, initiate reactions and control locomotion in complex chemical environments. MICREAgents lablets can join forces to communicate both chemicals and electronic information in order to solve complex tasks, acting as smart collective agents of chemical change. Like cells, they will be essentially genetically encoded, but with chemical and electronic memories, translating electronic signals into constructive chemical processing and recording the results of this processing. They will also reversibly employ DNA molecules as chemical information, for example to control surface-surface binding of lablets, or to program chemical sensors, not to synthesize proteins as in cells. The project builds on pioneering FET-funded work towards electronic chemical cells, taking a giant stride to cell-like microscopic autonomous chemical electronics with self-assembling electronic membranes controlling the entry and exit of chemicals. These autonomous mobile smart reactors will provide a novel form of computation that microscopically links reaction processing and chemical construction with computation, providing a radical integration of autonomous chemical experimentation. The self-assembling smart micro reactors can be programmed for molecular amplification and other chemical processing pathways, that start from complex mixtures, concentrate and purify chemicals, perform reactions in programmed cascades, sense completion, and transport and release products to defined locations. The project defines a continuous achievable path towards this ambitious goal, making use of a novel pairwise local communication strategy to overcome the limitations of current smart dust and autonomous sensor network communication. It will provide a technical platform spawning research in new computing paradigms that integrate multilevel construction with electronic ICT. The 10 groups, from 8 countries including Israel and New Zealand, are all pioneers in the multidisciplinary areas required to achieve the project goals, with a common grounding in IT.",Microscale Chemically Reactive Electronic Agents,FP7,31 August 2015,01 September 2012,3400000.0 MICRO AND NANO-NMR,Universiteit Twente * Twente University,health,"This proposal entails a post-doctoral project regarding the development and application of Micro- and Nanotechnology in Nuclear Magnetic Resonance (NMR) The focus is on high-resolution small-volume NMR spectroscopy and development of new scientific tools like miniaturized NMR, including the development of new techniques like small-volune hyphenated techniques as NMR-MS. The project comprises four main tasks, following the objectives: (i) Optimization and manufacturing of current NMR-on-a-Chip models, optimization of the NMR-chip, in particular regarding the materials to be used, the NMR coil design, the micro/nanofluidic systems and the optimal volume/signal-to-noise ratio. (ii) Design,optimization and manufacturing of advanced NMR-on-a-Chip: the design and development of NMR chips for multinuclear experiments with multiple coils, either parallel or in series, the integration of a variable temperature system. (iii) Testing of NMR chips with real reactions: testing of different reactions, screening of libraries of compounds in parallel microfluidic channels. (iv) Design and development of Micro and Nano NMR-MS hyphenated techniques. The Micro and Nano NMR project fits very well within the scope of differente strategic objectives of the 6th Framework European Programme (FP6). The development of new small-volume NMR techniques is a typical example of nanotechnology that can be applied to different fields, including life sciences. Indeed this project will obviously benefit any company in need of mass-limited samples. For example pharmaceutical companies looking for fast and cheap fabrication of screening of new medicinal compounds. Micro- and nanotechnology are currently among the most rapidly growing fields of research. The Supramolecular Chemistry and Technology group of prof. dr. David Reinhoudt and the MESA+ Research Institute for Nanotechnology of the University of Twente are among the leading groups world-wide and offer the perfect place for training in t",Micro- and Nanotechnology in Nuclear Magnetic Resonance,FP6,31 October 2008,01 November 2006,158326.0 MICRO FACETTE EYES,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,manufacturing,"Today we live in a world completely dominated by vision with a strong tendency to a constant increase of visual information. However, miniaturization of elements is done by applying similar optical principles known to the designers for many decades. Novel fabrication technologies are permanently developed and applied, but there is no consequent search for new vision principles to fully exploit the newly gained technological capabilities that allow completely new and unexpected fields of application. Main research projects at the Fraunhofer-Institute are related to these topics. Based on a strong experience in optics engineering and a well established facility of optical fabrication technology from macro- to nanoscale novel optical systems are developed. Recently demonstrated bio-inspired vision systems such as planar artificial compound eyes for ultra-compact image acquisition are just a first step in this direction. Within the proposed project, novel vision systems will be designed and manufactured applying electron-beam- and photo-lithography. The main focus of research is related to artificial receptor arrays on a curved basis. This is a highly demanding and at the same time promising topic not only for artificial compound eyes but also for the simplification of classical imaging systems. The major difference of natural and artificial image acquisition systems at this stage is the planar arrangement of the artificial receptor arrays compared to the curved geometry of the natural ones. This is the consequence of todays limitation to planar lithographic patterning technologies. The advantages of a curved basis compared to a planar one are obvious: There are the immanence of a large field of view, the avoiding of off-axis aberrations and declining illumination with increasing field angle. Different technologies are to be applied and evaluated such as laser-lithography on curved surfaces and polymer (flexible) artificial receptor arrays.","Design of adaptive artificial facette eyes, micro-optical fabrication using lithography, characterisation and application",FP6,31 December 2008,01 January 2007,149155.0 MICRO-FAST,MBN Nanomaterialia SpA,environment,"The aim of the project is to develop a completely new manufacturing system for the volume production of miniaturised components by overcoming the challenges on the manufacturing with a wide range of materials (metallic alloys, composites, ceramics and polymers), through: (i) developing a high-throughput, flexible and cost-efficient process by simultaneous electrical-forming and electric-fast-sintering (Micro-FAST); (ii) scaling up the process to an industrial scale; (iii) further developing it towards an industrial production system for micro-/nano-manufacturing. These will be enabled/supported by developing: (i) a new machine concept: Micro-FAST CNC Machine; (ii) an innovative inline monitoring and quality inspection system; (iii) innovative multiscale modelling techniques for the analysis of the micro-structural behaviours of materials and its interactions with the production processes; (iv) new tooling techniques for high-performance tools, and (v) high-performance nano-material systems. The whole development will take into account energy savings, cost and waste reduction, and recycling issues which will be studied thoroughly through an expertise Life-Cycle Assessment.","A FAST process and production system for high-throughput, highly flexible and cost-efficient volume production of miniaturised components made of a wide range of materials",FP7,02 April 2019,09 January 2013,0.0 MICROBONE,Vienna University of Technology * Technische Universität Wien,health,"Modern computational engineering science allows for reliable design of the most breathtaking high-rise buildings, but it has hardly entered the fracture risk assessment of biological structures like bones. Is it only an engineering scientist's dream to decipher mathematically the origins and the evolution of the astonishingly varying mechanical properties of hierarchical biological materials? Not quite: By means of micromechanical theories, we could recently show in a quantitative fashion how 'universal' elementary building blocks (being independent of tissue type, species, age, or anatomical location) govern the elastic properties of bone materials across the entire vertebrate kingdom, from the super-molecular to the centimetre scale. Now is the time to drive forward these developments beyond elasticity, striving for scientific breakthroughs in multiscale bone strength. Through novel, experimentally validated micromechanical theories, we will aim at predicting tissue-specific inelastic properties of bone materials, from the 'universal' mechanical properties of the nanoscaled elementary components (hydroxyapatite, collagen, water), their tissue-specific dosages, and the 'universal' organizational patterns they build up. Moreover, we will extend cell population models of contemporary systems biology, towards biomineralization kinetics,in order to quantify evolutions of bone mass and composition in living organisms. When using these evolutions as input for the aforementioned micromechanics models, the latter will predict the mechanical implications of biological processes. This will open unprecedented avenues in bone disease therapies, including patient-specific bone fracture risk assessment relying on micromechanics-based Finite Element analyses.","Multiscale poro-micromechanics of bone materials, with links to biology and medicine",FP7,31 October 2015,01 November 2010,1493399.0 MICROCARE,Science and Technology Facilities Council,information and communications technology,"Microsystems and Bioanalysis Platforms for Health Care - MICROCARE Miniaturisation of analytical systems is generally considered to be the strategy that will overcome the requirements of process speed for performing efficient evaluation studies. By utilising the versatility of silicon micromachining to fabricate efficient minute volume microstructures, it is possible to make analysis systems that are extremely small. The benefits of miniaturisation stem from the increased reaction kinetics in low volumes and the possibility to perform sample-handling procedures at a high speeds. Our research proposal is focussed on the implementation of micro/nano fabrication technologies for functionalised systems and sensors for bio-chemical analysis and micro delivery based on microtransducer array and micromachined modules. We propose to develop microfluidic devices, surface structuring and chemical organization methods to study both synthetic and systems biology. Additionally MEMS based devices will be developed for applications in life science research. The purpose is to form a network with the following aims: 1) to exploit synergies and complementarities (expertise and facilities) within the multidisciplinary partnership, through researcher mobilization, to conduct a focused research in life science 2) to address some of the theoretical and technological challenges, e.g. static and kinetic analyses with single molecular and cellular resolution and high throughput capabilities, 3) to use micro and nano techniques to develop appropriate systems and platforms to facilitate the defined research 4) develop a set of MEMs based devices for biomedical applications and 5) create a research climate within the partnership for long term collaboration between EU and China in this particular field. Investigations will be conducted through a collaborative process facilitated by a balanced exchange of researchers within the consortium.",Microsystems and Bioanalysis Platforms for Health Care MICROCARE,FP7,06 June 2016,07 January 2010,669600.0 MICRODROPCAT,Universiteit van Amsterdam * University of Amsterdam,health,"In this project we propose to develop new methodologies to prepare and screen large libraries of homogeneous catalysts based on supramolecular (self-assembled) ligands using droplet-based microfluidics. Presently, the discovery and design of efficient homogeneous catalysts still relies on time intensive trial-and-error methodology. To overcome these limitations, a new paradigm shift for the discovery of effective ligands relies on the supramolecular self-assembly of libraries of ligand through reversible non-covalent interactions. This significantly increases the potential chemical space within which an optimal ligand set can be found. The full potential of this methodology is impeded by current synthesis and screening techniques which rely on macroscale (mL) trial for all the ligands sets and reaction conditions. One effective strategy to increase the rate at which reactions can be performed at is through extensive miniaturization of the reaction vessel. Recent advances in droplet-based microfluidics have enabled the effective screening of reaction conditions on a nano- to pico- liter scale. We thus propose to develop, in collaboration with a lab-on-a-chip research group, a modular droplet-based microfluidic device which will enable the generation, within a nanoliter droplet, of supramolecular catalyst made up of self-assembled ligands around a transition metal. These catalytic droplets will then be merged with a stream of reactants to form a nanoliter-size reaction size vessel which will enable the catalytic activity of the self-assembled catalyst to be evaluated. The intended outcome of this project is to greatly accelerate the speed at which an active catalyst can be identified at. This will have a broad impact on the chemical community for which screening methodologies have become an integral part of the discovery process (e.g. drug discovery).",Application of Droplet-Based Microfluidics for the Screening of Supramolecular Catalysts,FP7,31 December 2009,01 July 2008,157733.0 MICROFLEX,University of Southampton,information and communications technology,"This proposal concerns flexible materials in the form of high added value smart fabrics/textiles which are able to sense stimuli and react or adapt to them in a predetermined way. The challenge for the European textile industries is to add advanced functions to textiles and the recent progress of new technologies such as electronic inks provide an opportunity for a breakthrough by incorporating MEMS on flexible textiles/fabrics. The project will exploit microfabrication to produce, using custom printing processes, active functions cost efficiently. We propose to develop fundamental micro fabrication production technologies for MEMS on fabrics/textiles using flagship demonstrator applications. This will result in a cheap, easy to design, flexible, rapid, way to manufacture multifunction smart textiles/garments for a large set of multi-sectorial applications. The processes will be based on thick film printing and sacrificial etching for the MEMS structures. Subsequent inkjet printing will be used to deposit thinner structures on the thick film printed layers incorporating for example active nanoparticles to add further functionality. These printing processes have many benefits including low-cost, repeatability, flexibility, suitability for high throughput production, relatively inexpensive equipment, short development time and the capability of depositing a wide range of materials. All the novel printed inks will be electrically activated sensors and actuators and we will use standard electronic devices for power supply/storage, signal processing and communications offering low price and mass production. The project will undertake a number of initial demonstrators of the underlying basic technology. These will be based on: light emission, cooling/heating, anti-static effect, energy harvesting, micro-encapsulation and actuation. MICROFLEX is a perfect example of the transformation of a resource-intensive to a knowledge-intensive industry.",Micro fabrication production technology for MEMS on new emerging smart textiles/flexibles,FP7,10 July 2014,11 January 2008,5429450.0 MICROFLUID,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Lab-on-chips (LOCs) are microsystems capable of manipulating small (micro to nanoliters) amounts of fluids in microfluidic channels with dimensions of tens to hundreds of micrometers: they have a huge application potential in many diverse fields, ranging from basic science (genomics and proteomics), to chemical synthesis and drug development, point-of-care medical analysis and environmental monitoring. Polymers are rapidly emerging as the material of choice for LOC production, due to the low substrate cost and ease of processing. Notwithstanding their potential, LOC commercial exploitation has been slow so far. Two breakthroughs that could promote LOC diffusion are: (i) a microfabrication technology with low-cost rapid prototyping capabilities; (ii) an integrated on-chip optical detection system. In this project we propose the use of femtosecond lasers as a novel highly flexible microfabrication platform for polymeric LOCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. Femtosecond laser processing is a direct, maskless fabrication technique enabling spatially selective three-dimensional material modification. It will be employed in different steps of the LOC production cycle: (i) rapid prototyping of the microfluidic chip using laser ablation or two-photon polymerization; (ii) direct fabrication of optical waveguides and integrated photonic components on the LOC for in situ optical sensing; (iii) master tool fabrication for mass production by replication techniques. The laser fabrication technology will enable to implement a variety of microfluidic LOCs with integrated photonic functionalities. In this project we concentrate on two prototypical applications in the fields of food quality and environmental sensing: LOCs for detection of mycotoxins in animal feeds and LOCs for water screening to detect bacteria and heavy ions contamination.",micro-Fabrication of polymeric Lab-on-a-chip by Ultrafast lasers with Integrated optical Detection,FP7,31 October 2011,01 June 2008,3200000.0 MICROMEGAS,Claude Bernard University Lyon 1 * Université Claude Bernard Lyon 1,health,"Nanofluidics is an emerging field aiming at the exploration of fluid transport at the smallest scales. Taking benefit of the specific properties of fluids in nanoconfinement should allow to challenge the limits of macroscopic continuum frameworks, with the ultimate aim of reaching the efficiency of biological fluidic systems, such as aquaporins. Carbon nanotubes have a decisive role to play in this quest, as suggested by the anomalously large permeabilities of macroscopic carbon nanotube membranes recently measured. This behavior is still not understood, but may be the signature of a 'superlubricating' behavior of water in these nanostructures, associated with a vanishing friction below a critical diameter, a result put forward by our preliminary theoretical results. To hallmark this grounbreaking behavior, it is crucial to go one step beyond and investigate experimentally the fluidic properties inside a single carbon nanotube: this is the aim of this proposal. To this end, the project will tackle two experimental challenges: the integration of a single nanotube in a larger nanofluidic plateform; and the characterization of its fluidic properties. To achieve these tasks, we propose a fully original route to integrate the nanotube in a hierarchical nano to macro fluidic device, as well as state-of-the-art methods to characterize fluid transport at the 'zepto-litter' scale, based on single molecule fluorescence techniques and 'patch-clamp' characterization. In parallel, experimental results will be rationalized using modelization and molecular dynamics. This project will not only provide a thorough fundamental understanding of the properties of carbon nanotubes as fluidic transporter, but also provide an exceptional nanofluidic plateform, allowing to explore the limits of classical (continuum) frameworks. It will also allow to envisage future potential applications, eg for desalination, separation, energy converter, jet printing, ...",Nanofluidics inside a single carbon nanotube,FP7,31 December 2016,01 January 2011,2418000.0 MICRONANOTOX,Natural Environment Research Council,environment,"Nanotechnology is already used in a huge variety of applications with a resulting potential environmental exposure. However, we are still lacking sound scientific knowledge on the ecological consequences for natural environmental systems of exposure to man-made nanoparticles (NPs). While standard ecotoxicity tests can be modified for hazard assessment of such NPs, the tests and therefore the conclusions address the wrong endpoints such as high-dose effects on survival and reproduction. This may have little relevance to possible effects on structure and function of natural ecosystems predicted to be exposed to low doses. Therefore the overall aim of this project is to link modern molecular biology and nano-ecotoxicology to address the interplay between effects of engineered NPs on microbial community structure and function and the consequent effects on their ecosystem function roles and rescilience.",Microbial community nano-ecotoxicology: interplay between effects on structure and the consequent effects on function.,FP7,04 June 2016,05 January 2012,0.0 MICROSURFTAS,University of Limerick,information and communications technology,"With the advent of Micro-Electro-Mechanical Systems (MEMS), there is considerable potential for so-calledbio-MEMS devices - microsystems for the automated analysis and continuous processing of biological samples.Bio-chips, Lab-on-a-chip, m-Total Analysis Systems and Bio-sensors are some of the terms used todescribe bio-MEMS devices, and m-TAS is the term which is used throughout this proposal. The applications of m-TAS cover a broad range: point-of-care diagnostics, pharmacogenomics, high-throughput drug discovery,forensics, food-safety, plant genomics, agriculture and military applications. m-TAS offer two key advantagesover existing macro-scale technologies: scale - large sample volumes of biofluids are not required; and speed - very high throughput can be achieved, with continuously-flowing, massively-parallel device. The StokesResearch Institute (SRI) located at the University of Limerick (UL), Ireland is currently active in micro TotalAnalysis System (m-TAS) research. A barrier to the present m-TAS research stream is a lack of knowledge regarding the compatibility of bio-fluidicsamples with micro-device materials. Such specialist knowledge is vital in terms of the propagation of thevarious reactions which must take place in a m-TAS device, impacting on efficiency, and on contamination,impacting on usability and dependability.MicroSurfTAS, a Marie Curie Host Fellowship for the Transfer of Knowledge is therefore proposed to impartknowledge centred on bio-fluid and surface interaction. The Fellowship will fund one more experiencedresearcher to advance surface fluid compatibility knowledge, and two experienced researchers to address samplecontamination issues.The outcome of the Host Fellowship will be the acquisition by the SRI of materials biocompatibility andcontamination expertise related to micro-systems for the processing of DNA.",Micro Surface Science of Materials for Micro Total Analysis Systems,FP6,30 April 2006,01 May 2004,371733.0 MICROTHRUST,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"Our MicroThrust proposal addresses the FP7 target for advanced in-space propulsion technologies for solar system exploration. This research provides a key component in facilitating exploration missions: a technology that can substantially reduce the cost of undertaking particular types of robotic exploration. Building on the framework of a successful ESA study, our team of leading academics, research institutions and space companies has developed a conceptual design of a very small, yet highly performant electrical propulsion system. The conceptual design is based upon experimental data already obtained by team members. As a result we are confident that this system can provide the transportation element for taking nano/micro satellites to any location in the Earth-Moon system and will even allow missions to nearby planets and asteroids. The propulsion system will thus permit new exploration mission concepts. These missions due to their size will be developed within a fraction of the time for conventional missions. Their simplicity, perhaps even single instrument spacecraft, will reduce risk for carrying out the mission. Overall this will dramatically reduce cost of individual missions, thus providing more flight opportunities for planetary scientists and planetary exploration.",MEMS-Based Electric Micropropulsion for Small Spacecraft to Enable Robotic Space Exploration and Space Science,FP7,11 June 2015,12 January 2010,0.0 MICROVIB,University of Franche-Comte * Université de Franche-Comté,information and communications technology,"Microsensor and microactuator technologies are of strategic importance for the EU. In particular, the association of silicon micromachining with integrated optics (IO) have the advantage of small scale, easy integration and appropriate size to control or manipulate optical radiations. It can result in the production of miniaturised, low cost and smart optical microsensors with moving parts. This technology is therefore suitable to fabricate precision-defined optical components and offers a relative easy alignment procedures of optical with mechanical parts. With the support of GROWTH programme (proposal "OCMMM", G1RD-ct-2000-00261, Jan. 2001) we proposed the development of an innovative on-chip testing technology for in situ metrology of MicroElectroMechanical Systems (MEMS). This is based on in-situ optical interrogation of mechanical parameters by incorporating a sensing arm of an integrated Mach-Zehnder interferometer into actuated MEMS structures. In this case the microinterferometer cannot be reused for other systems. The alternative is the combination of previously developed opto-mechanical technology with fiber-optic and microactuator technology. Optical microsensors, based on phase-modulated detection, can provide high resolution measuring. Thus, the present proposal is an accompanying measure for OCMMM proposal aiming the realisation of a low-cost ex-situ optical vibrometer, based on an integrated Michelson interferometer with two reference arms and one sensing arm. each of them connected to an optical fiber. Electrostatically driven mirror creates a phase modulation between both the reference arms of the interferometer. The research project couples the distributed potential of both Applicant and Host Organisations. Applicant task will be the design, realisation and testing of proposed electrostatically heterodyned optical vibrometer. By strong contacts with SMEs, the project offers the opportunity to make research in the context of industry requi",Implementing and calibration of integrated optical strategy for ex situ vibrometry of Micro-Electro-Mechanical Systems,FP6,28 February 2006,01 March 2004,102982.0 MIEDFAM,Vienna University of Technology * Technische Universität Wien,information and communications technology,"During the last few years, atom chips have been successfully developed for experimental studies on mesoscopic ensembles of ultracold atoms. They consist in surface-mounted microstructures (among several µm to 100 nm), which allow the generation of the fields, required for confining and cooling of neutral atoms. Bose Einstein condensation of alkalis, like Rb87, is optimally achieved with such chips. The theme of this project is the development and construction of the next generation atom chip. Recent experiments on an atom chip have demonstrated a a phase preserving matter wave interferometer based upon radiofrequency-induced (several hundred kHz) adiabatic potentials. However, in order to control and manipulate the hyperfine degrees of freedom (F = 1, 2) of the Rb87 ground state, electromagnetic fields with frequencies of several GHz are necessary. The first part of this project will be the design of new generation atom chips containing microwave circuits, which will enable the interaction of the atoms with the near microwave fields. The adiabatic RF induced potentials will render new trapping geometries possible. The same technique will be extended to the Microwave regime, enabling the production of state-dependent potentials, which is essential for possible implementation of quantum computation in atom chips. Within the project, complex atom chips will be developed and fabricated. They will be mounted in an existing set-up for housing atom chips at the Host institution and experiments on the manipulation of all degrees of freedom of Rubidium will be performed with the mentioned techniques. By means of interferometry experiments, the coherence of mesoscopic ensembles of atoms close to the chip surface will be investigated. Moreover, the coupling of the atoms to a microwave resonator on the chip will be experimentally investigated. This might lead to a new not optical detection scheme of the atoms.",Micromanipulation of intern-extern degrees of freedom of mesoscopic atomic ensembles.,FP6,31 December 2008,01 January 2007,149962.0 MIFS4BIOMED,Linköping University * Linköpings Universitet,health,"Molecular imprinted polymers and electrospun nanofibres are both hot topics individually in the biomedical sciences, with applications including tissue engineering, regenerative medicine, drug release, affinity chromatography and biosensors. This proposal combines these two leading-edge approaches to generate entirely novel materials with broad utility in biomedical engineering. Molecular imprinting is a form of template assisted synthesis that facilitates the creation of artificial receptors that can have affinity constants as high as their natural counterparts. Electrospinning (ES) is one of the most broadly used techniques for fabrication of nanostructured materials. ES uses electrical forces to produce continuous fibres having diameters in range of few nanometers to several micrometers. ES offers several technical advantages such as extremely high surface area per unit volume, tunable porosity, flexibility for adapting it to different shapes and sizes, and possibilities for controlling nanofibre composition. In this proposal, we have focused on next generation molecular imprinting using reactive electrospinning to obtain directly imprinted nanofibres. We will demonstrate the utility of this new nanofabrication technology in three key areas: active agent carriers in regenerative medicine, affinity depleting membranes in blood-related proteomics, and biorecognition elements for biosensors. The multidisciplinary nature of the project will make important contributions to the development and validation of new therapies, sustainable and efficient healthcare systems, and strengthening the competitiveness and innovative capacity of European health-related industries. We will be working at the frontiers of two leading research areas having the potential to attract the attention of the researcher community not only in Europe, but also world wide, and to make significant contribution to EU's research priorities, sustainable development and scientific competencies.","Molecularly Imprinted Nanofibres for Tissue Engineering, Affinity Depletion and Biosensor Applications",FP7,31 August 2016,01 September 2014,275138.0 MIME,University of Copenhagen * Københavns Universitet,environment,"The behavior of metals, many of which are toxic even in trace quantities, is an important topic as population growth puts pressure on the world’s drinking water resources. Relatively little is yet known about the interdependencies between the biotic and abiotic aspects of metal sorption. The overall aim of my project is to define the processes by which microbial metabolites mediate Pb sorption on calcite. I will use a combination of surface sensitive techniques, including X-ray Photoelectron Spectroscopy (XPS), Atomic Force Microscopy (AFM), and Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D) to extend current understanding of the biogeochemical controls on Pb behavior to the molecular scale. My study lies at the intersection of geoscience, surface physics and biointerface science and uses an interdisciplinary approach to answer questions at the crossover of environmental bio- and geochemistry, that are critical for society. The results will provide insights for the water industry, so treatment can be improved by providing criteria for selecting bacteria that can synthesize particular metabolites to immobilize specific toxic metals. Internal corrosion of Pb pipes in water distribution systems is currently an immediate, world-wide public health concern. A recent study estimated that 25% of houses in the EU have at least one Pb pipe, putting 120 million Europeans at risk. My background in drinking water treatment, the new expertise I will gain and the results from the MiMe project will address this concern. I bring my experience and motivation to the members of the Nano-Science Center, to exchange for the opportunity to learn new skills on a set of unique instruments that can “see” at the molecular-level. This new knowledge will form the base for my future research. Indeed, my host, Prof. Stipp’s expertise in the nano-scale processes on mineral surfaces is at the top of the field; I will benefit tremendously from my time at the University of Copenhagen",The Role of Microbial Metabolites in Pb-Calcite Surface Interactions,FP7,08 July 2015,09 January 2011,230627.2 MIMEFUN,Aalto University * Aalto-yliopisto,manufacturing,"Energy efficiency and sustainability encourage to develop lightweight materials with excellent mechanical properties, combining also additional functionalities and responses. Therein nature allows inspiration, as e.g. pearl of nacre and silk show extraordinary mechanical properties due to their aligned self-assemblies. However, biological complexity poses great challenges and in biomimetics selected features are mimicked using simpler concepts. Previously artificial nacre has been mimicked by multilayer and sequential techniques and ice-templating. However, concepts for aligned spontaneous self-assemblies are called for scalability. We will develop toughened nacre-inspired materials by templating functionalized polymers on colloidal sheets in suspension, followed by self-assembly by solvent removal. Similarly, we will develop silk-mimetic materials using aligned organic fibrous reinforcements in soft dissipative matrix. Nanofibrillated cellulose will be wet-spun using extrusion into coagulant bath, followed by post drawing, drying and functionalization to allow silk-like fibers with high mechanical properties. In another route, cellulose rod-like whiskers will be decorated with soft functional polymers allowing energy dissipation, followed by alignment and interlinking to mimick silk-assemblies. The colloidal routes allow also new functionalities by using functional polymers, e.g. electroactive and conjugated polymers and nanoparticles. Importantly, redox-active polymers are bound on the colloidal sheets. Incorporating in a planar electrochemical cell with flexible electrodes, electrochemical switching of stiffness is obtained using a small voltage, as the intercolloidal interaction is controlled by the charge state of the redox-active layers. This would allow a new class of material, eg. to interface users and devices. In summary, we present a colloidal self-assembly platform for biomimetic materials with exciting mechanical, functional, and switching properties.",Biomimetics for Functions and Responses,FP7,03 July 2019,04 January 2012,2296320.0 MIMIC,Imperial College London,health,"Although cancer is a merciless disease, many cancers can be cured if detected in an early stage. This piece of evidence has pushed the scientific community hard to develop new diagnostic tools for the early detection of cancer. MIMIC aims to be a breakthrough in cancer diagnostics by combining extreme sensitivity with design flexibility in a detection platform that can be easily mass-fabricated, therefore granting the easy commercialization of the device for its use in healthcare. In this approach, a microchip that contains multiple electrodes is fabricated with standard procedures in the microelectronics industry. Each electrode is selectively modified with capture probes for different cancer biomarkers by trapping antibodies in a collagen matrix that is generated in situ on each sensor. This biomimetic gelation process, triggered by the application of an electric field with an atomic force microscope, allows one to obtain a complex device starting from a disposable, mass-produced chip. After recognition of the biomarkers with secondary antibodies labeled with alkaline phosphatase, the enzyme generates calcium phosphate crystals as observed in biomineralization processes. Subsequently, the presence of the crystals on the electrodes is detected as the signal of the bioassay by measuring the capacitance of the solution between the electrodes on the chip and the tip of an atomic force microscope as the counter electrode. By using the crystals fabricated by the enzyme as seeds to promote biomimetic crystal growth, multiple biomarkers could be detected at the single-molecule level. The project seeks several scientific milestones, such as the fabrication of the first marketable device that can detect several proteins at the single-molecule level and the integration of atomic force microscopy for protein concentration and reading the chip, which will surely boost the competitiveness of the European Union in the economically relevant fields of healthcare and nanotechnology",Minerals Integrated into Multiple Identifications of Cancer (MIMIC): a multidisciplinary approach for the ultra-sensitive detection of cancer biomarkers,FP7,28 February 2013,01 March 2011,212092.0 MIMOMEMS,National Institute for Research and Development in Microtechnologies * Institutul National de Cercetare-Dezvoltare pentru Microtehnologie,photonics,"The aim of the MIMOMEMS project is to bring the research activity in RF and Optical-MEMS at IMT-Bucharest to the highest European level and create a European Centre of Excellence in Microwave, Millimetre Wave and Optical Devices, based on Micro-Electro-Mechanical Systems (MEMS) for Advanced Communication Systems and Sensors The main objectives of the project support high level research activities in RF and Optical MEMS, through the following objectives: i. Know-How and Experience Exchange: Twinning actions with two research centres: a) LAAS-CNRS Toulouse with a strong expertise in silicon based millimetre wave microsystems and photonic devices, and b) FORTH-IESL-MRG Heraklion with excellent knowledge of IIIV's ii. Recruitment by IMT:. Post-Docs. with expertise in nanophotonics and microwaves, will be hired for increasing IMT s human potential iii. Development and Upgrade of Research Equipment: About 50% of project founds will be used for the upgrading and purchasing new equipments (on wafer characterization up to 110GHz, new nano-characterization equipment –SNOM, etc) iv. Workshop, Conference Organisation and Policy Development. Organize of scientific events, thematic sessions and seminars supporting knowledge transfer and research policy development v. Dissemination and Promotional Activities: Promotion of activities and results through a project website; publication in reviewed journals and conferences; organization of workshops, FP7 proposals. The MIMOMEMS project will directly address research objectives from FP7 Work Programmes: 1.Capacities - Part 4 - Research Potential. Activity: 4.1.Unlocking and developing the research potential in the EU´s convergence regions and outermost regions 2.Cooperation -Theme 3 - ICT. Challenge 3: Components, systems, engineering:3.1; 3.5; 3.6 Objective.3.1: Next-Generation Nanoelectronics Components and Electronics Integration Objective.3.5: Photonic components and subsystems Objective 3.6: Micro/nanosystem","European Centre of Excellence in Microwave, Millimetre Wave and Optical Devices, based on Micro-Electro-Mechanical Systems for Advanced Communication Systems and Sensors",FP7,30 April 2011,01 May 2008,1100000.0 MIMOSA,STMicroelectronics SA,information and communications technology,"The Microsystems platform for MObile Services and Applications (MiMOSA) is an integrated project done by a strong and synergetic consortium. MiMOSA creates a new open system platform for context-aware mobile services and applications. The approach is mobile phone based, providing the users with a smooth transition from current mobile services to ambient intelligence services. In the area of short-range connectivity, MiMOSA positions itself to low-cost, low-bit rate territory that can be set up with relatively modest investments in the infrastructure. The main focus of MiMOSA is the development of novel low-power microsystems, in particular wireless sensors exploiting the RFID technology, highly integrated readers/writers for RFID tags and sensors, low-power MEMS-based RF components and modules, low-power short-range radios, advanced integration technology, and novel MEMS sensors for context sensitivity and intuitive, user-friendly interfaces. MiMOSA extends the area of telecommunication business to ambient intelligence. The MiMOSA project is organized in 6 work packages including management. Its design approach is strongly human-centred. End users and application developers participate in designing and evaluating how ambient intelligence and short-range communication with environment could be best utilised in the everyday life. User feedback guides the design of the core components of ambient intelligence. To demonstrate the generic characteristics of the platform, MIMOSA develops specific applications with particular emphasis on physical browsing, health monitoring, intelligent housing, fitness/sports, context awareness for ambient intelligence and intuitive user interfaces. The defined approach and results will be disseminated and will lead to innovation in other application domains.Tomorrow's ambient intelligence will be enabled by generic technologies such as proposed by the MiMOSA vision in which cultural, ethical and/or gender issues are directly addressed.",MIcrosystems platform for MObile Services and Applications,FP6,30 September 2006,30 December 2003,9995497.0 MINAM 2.0,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),health,"MINAM 2.0 will contribute to enabling a new dimension of quality with respect to the cooperation of the single groups in the micro- and nanotechnology (MN) manufacturing. MINAM aims at bringing together existing and well established (local) Micro Nano related organizations: the microclusters in the European regions, networks of Excellence, Associations, Research infrastructures, European projects and decision makers in the MN community. Through regional clusters with their strong industrial backbone MINAM 2.0 considerably contributes to the participation of the industry in European decision processes in this thematic area. The cooperation between MINAM and European application and technology platforms promoted at European level will improve the exchange between application requirements and technical capabilities, aiming at the identification of common objectives and requirements. MINAM will provide a significant contribution to identification of Cross sectional Joint Research agenda (together with other ETP´s) and allows for a derivation of concerted partial roadmaps for the different thematic areas in MNT (Assembly, Micro/Nanotechnologies, System integration). To obtain sustainability MINAM 2.0 will be established as a 'one stop shop' hub for exchanging information, adding value to all players in this area of interest. The hub will also push the improvement of cooperation between the regional key players in the European regions. A close connection to Manufuture, Nanofutures and other ETPs in the NMP area will ensure that double activities are cut down to a minimum and strenghten the production technology as a whole through its specific view on aspect of highly micro relevance, such as precission assembly, characterization, micro sensorics, etc. For the intended target application areas (EUROP, Nanomedicine, Food ...) all this will lead to an improved information flow about new developments in Nano-Microsystems as one of the key enablers for new products","Paving the ground for the second generation of a highly effective, application oriented MicroNano Manufacturing community in Europe",FP7,30 November 2012,01 December 2010,615200.0 MINAMI,STMicroelectronics SA,information and communications technology,"MINAmI addresses AmI applications where personal mobile devices act as a gateway to AmI. MINAmI vision makes the user progressively be in control of his AmI environment, then interact with everyday objects to monitor and control environmental or health parameters. MINAmI develops tools, methodologies and an open platform and implement these technologies into real devices/systems in demonstrators. Ethics and privacy issues linked to AmI will be strongly assessed as well as user acceptance of the solutions. MINAmI multidisciplinary and participatory design approach will reduce the time to adopt AmI disruptive concept, facilitating a constant dialogue between technology and application developers, end users and application field experts. The open platform previously developed in MIMOSA will be enriched in MINAmI as new technologies offer more functionalities for wider applications. Micro-Nano smart devices with enhanced short range connectivity will be developed and validated through field trials in wide and transverse applications, from consumer to niche markets. The main technical focus in MINAmI is in the development of: -mass storage RF tags based on low power innovative technologies -active event sensitive tag technology including new low-cost time reference -low-cost/low-power sensors and actuators including nanosensors, 9D integrated Inertial Measurement Unit and 3D distributed vision systems In MINAmI, a global platform taking into account the constraints of integration, industrialisation and compatibility with advanced CMOS platforms will integrate these technologies. MINAmI links demonstration, validation and exploitation. Service providers and companies will develop and support the applications in pre-competitive products that include: -drugs monitoring and conditioning -health monitoring and homecare -assistive listening device -data downloading from passive tags -ambient sensors for friendly home applications -virtual optical user interface",Micro-Nano Integrated Platform for Transverse Ambient Intelligence Applications,FP6,30 September 2009,30 September 2006,1.01996788E7 MINANO,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,health,"Successful adaptation of nanotechnology in the end-products requires an access to the nanofiller technology and to the raw materials. The MINANO-project brings together partners representing end-user's product know-how, formulation and processing technology and most importantly secure and reliable source of nano raw materials. Although there has been tremendous development in the area of nanocompounds with improved functionality, there exists a need to develop an efficient, continuous method of large-scale, low-cost synthesis of such materials. To answer to this need the following steps are suggested: 1) Integrate the functionalization of the high-quality nanoparticles directly on the continuous mass-production process already in the mining industry, 2) ensure controlled dispersion to the matrix material in large scale by cooperation between nanoparticle producer and end-product manufacturer, 3) assure sustainable and safe production and use by state-of-the-art life-cycle analysis. Based on the mass production process and cooperative value chain we concentrate on three major functionalities: Flame retardancy, UV resistance and antimicrobial properties. These properties are achieved by functionalized Mg(OH)2, ZnO and Ag nanoparticles. Societal and industrial impacts of these properties are extensive and there is a strong request of these functionalities for both plastic and wood-plastic based matrix materials. The use of nano-sized functional filler materials enables to use smaller amount of additives thus giving better recyclability, lower weight, higher mechanical strength and potential multifunctional features to the end-product. The combination of new nanofunctionalities gives far reaching possibilities for new types of functional plastics, and completely new possibilities to wood-plastic composites as well. This moves both mining industry and end-product companies towards high-tech on the long run.",New high-quality mined nanomaterials mass produced for plastic and wood-plastic nanocomposites,FP7,31 December 2013,01 October 2010,1494447.0 MINASYS-COE,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),information and communications technology,"The purpose of the present proposal is to extend and improve the existing facilities and know-how at the Institute of Microelectronics (IMEL) of the National Center for Scientific Research (NCSR) “Demokritos”, recognized as Center of Excellence in Nanoelectronics and MEMS in Greece, and organize and coordinate the access to the infrastructure at regional, national and EU levels. Dissemination and networking activities will be also organized, targeting mainly, but not exclusively, collaborations with the countries in Southeastern Europe in the field of nanofabrication, nanodevices and sensors/MEMS/NEMS. With the existing expertise, know-how and state-of-the-art infrastructure and facilities, complemented by important new equipment that will be purchased within the present proposal, MiNaSys Center of Excellence (MiNaSys-CoE) aims at becoming unique in the Southeastern Europe region. The instruments for the implementation of MiNaSys-CoE will be the following: • Extending and upgrading the existing infrastructure • Recruitment of experienced scientists and engineers • Development of the access to the existing facilities and know-how • Development of networking activities and strategic partnership with other leading research groups in Europe. • Organization of scientific events, thematic sessions and seminars supporting knowledge transfer and research policy development. • Dissemination of results and activities",Micro and Nano Systems Center of Excellence - IMEL/NCSR DEMOKRITOS,FP7,07 July 2015,12 January 2009,2003085.45 MINATRAN,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,information and communications technology,"The objective is to develop a robust multifunctional framework/probe for capturing the evolution of deformation and failure in a variety of processes at the micro-nano transition regime. An interdisciplinary approach will be pursued based on fundamental theory and experiment, in conjunction with multiscale simulations for micro/nanotechnology applications. The approach is unconventional as it ventures to extend continuum mechanics down to the micro/nano regime and verify this through nanoindentation and atomic force microscopy techniques. It is also unique as the new phenomenology introduced for establishing this extension (higher order gradients accounting for microscopic processes and interfacial energy terms accounting for nanoscopic phenomena) will be substantiated through hybrid (ab initio-atomistic-defect-finite element) simulations. The framework will be employed to consider fracture and size effects in a number of micro-nano scale transition configurations ranging from nanograined aggregates and nanolayered structures to nanotubes and micropillars, and from Li-ion battery electrodes to bioactive interfaces. Other micro/nano objects such as quantum dots, nanowires and NEMS/MEMS devices, as well as biomolecular microcrystalline membranes leading to living cell division will be considered. In a sense this “scale” transition theory is reminiscent in scope to Landau’s “phase” transition theory where a variety of different physical phenomena can be treated within a common framework. This optimism stems from the PI’s previous success with this approach, as well as Smalley’s remark that the “laws of continuum mechanics are amazingly robust for treating even intrinsically discrete objects only a few atoms in diameter”. A good mix of young researchers and mature scholars will be employed, thus connecting people and ideas through joint publications and scholarly activities in a critical area of fundamental and applied research.","Probing the Micro-Nano Transition: Theoretical and Experimental Foundations, Simulations and Applications",FP7,09 June 2015,10 January 2008,1128400.0 MIND,Meggitt A/S,health,"The objectives of the NoE MIND are to increase the level of understanding of all phenomena in piezoelectric materials and structures, and to apply this knowledge to the design of new and improved devices such as sensors, transducers, actuators and motors for applications ranging from medical diagnostics and therapy to industrial measurements, as well as transportation and products for the citizens. This NoE proposal aims at the creation of a European Institute on piezoelectric materials, structures and devices; through durable integration of research teams covering expertise ranging from material synthesis to integrated device development. The scientific objectives will concentrate on miniaturisation and integration of piezoelectric structures (mainly on silicon), and multifunctional devices such as multiple sensors or intelligent structures, in which the piezoelectric properties are combined with other properties to obtain new or improved devices. This will be made possible through the association of a wide range of scientific competencies (chemistry and process engineering, solid state physics, material characterisation and measurement science, micro-/nano- technology and MEMS, numerical modelling, device design, manufacture and test) all working towards common objectives: investigation of phenomena in piezoelectric/ferroelectric materials, optimisation of properties for different applications, and integration of piezoelectric structures in devices. Such expertise is currently disseminated in many groups throughout Europe, without common management structures. MIND network will therefore integrate human resources and equipment both scientifically (exchange of personnel, methods, processes) and structurally (information flow, interactive internet resources and forums, meetings, common scientific strategy and organisation, common training degrees). A durable administrative structure is expected to be set up before the end of Year 3 of MIND.",Integrated Piezoelectric Devices,FP6,28 February 2010,01 March 2005,7392000.0 MINE,ICN2 - Institut Català de Nanociència i Nanotecnologia,environment,"The main objective of the 3 years research activity herein described is the design and development of protocols for the colloidal synthesis of a new generation of multi-component hybrid nanocrystals (HNCs) with precisely tunable properties and applicability in energy conversion, (photo)catalysis and environmental remediation. In this context, MINE aboard the most problematic points related to the growth of multi-component materials, in particular the conditions by which it is possible to tune both, the materials that compose the structure and the morphology of the final structure (core-shell or oligomer-like configurations), by integrating the synthesis, the structural characterization and the study of NC properties. Among all the systems we will focus on the design and development of synthetic strategies for the production of metal-semiconductor, metal-semiconductor oxide and metal-metal oxide. The research activity has been divided in four different parts: i) the development of synthetic strategies for the production of multicomponent hybrid NCs, ii) the characterization and study of their physico-chemical properties, reactivity and structure-activity relationships iii) the study of their applicability and iv) the determination of their long-term use in terms of safety, sustainability and feasibility, a necessary step before promoting the \"real\" applications of these novel exciting nanostructures.We expect that results arising from MINE, will allow not only preparing new and long sought materials, but also re-designing many of the existing materials and recipes, and therefore moving the state of the art to the next step, which can be seen as the fifth-generation of NCs by design",Developing New Strategies for the Production of Viable Hybrid Nanocrystals with Applicability in Energy Conversion and (Photo)catalysis.,FP7,11 June 2018,12 January 2012,75000.0 MINERVA,Koç University * Koç Üniversitesi,health,"'There's Plenty of Room at the Bottom', stated by Nobel laureate Richard Feynman, describes the possibility of manipulating individual atoms and molecules to realise nanomachines. Emerging nanoscale applications mandate enabling nanomachines to communicate and form nanonetworks to overcome the limitations of a single one. Thus, our aim is to find the answer to the profound question, i.e., 'is the room down there sufficient for a communication network?' Thanks to natural evolution, the affirmative answer is right inside us. Human body is a large- scale communication network of molecular nanonetworks composed of billions of nanomachines, i.e., cells, which use molecules to encode, transmit and receive information. Any communication failure that is beyond the recovery capabilities of this network leads to diseases. In this project, first, (1) we will investigate the communication theoretical foundations of nanoscale neuro-spike communication channels between neurons. Second, (2) we will study multi-terminal, i.e., multiple-access, relay, broadcast, neuro-spike channels and nervous nanonetwork in terms of communication theoretical metrics. Third, (3) we will validate our channel and nanonetwork models with physiological data, and develop a nervous nanonetwork simulator (N4Sim). Finally, (4) we will develop the first nanoscale bio-inspired communication system for ICT-inspired neuro-treatment for spinal cord injury, i.e., nanoscale artificial synapse, which will mimic neuron behaviour by realising both electrical and nanoscale molecular communications.The MINERVA project will pave the way for the realisation of emerging nanonetwork applications with significant societal impact, e.g., intra-body networks for health monitoring, drug delivery, chemical and biological attack prevention systems. The project will help develop the future ICT-inspired treatment techniques for communication related neural disorders.",Communication Theoretical Foundations of Nervous System Towards BIO-inspired Nanonetworks and ICT-inspired Neuro-treatment,FP7,28 February 2019,01 March 2014,1757039.0 MINOS,University of Vienna * Universität Wien,photonics,"Micro- and Nanomechanical systems have the potential to revolutionize Information Science Technologies (IST) by bringing back mechanics as an essential component to information processing with completely new versatility. Already now, these systems are about to provide a broad range of novel applications with impact in a variety of fields such as life sciences, optical sciences, materials science and, eventually, quantum information science. European research has to play a central role in this exciting development. This STREP will provide future key technologies to achieve this goal. Downsizing mechanics to micro- and nanomechanical systems allows entering a novel regime in which the mechanical properties can directly be manipulated by light and vice versa. These optomechanical effects open up a completely new field of controllable light-matter interaction on the micro- and nanoscale. At present, Europe is among the key players in this young and emerging field of micro- and nano-optomechanical systems (MOMS/NOMS). The proposed STREP collects Europe's leading scientists in the field to foster European competitiveness and to constitute clear lead competences. One main objective of the research initiative will be the development of new knowledge, methods and applications that can establish MOMS/NOMS as a future key technology for nanoscience. The prospects are clear: since both photonics and nanoscience will certainly play a vital role in future ICT, a combination of these technologies has the potential to create synergies of unpredictable impact.",Micro- and Nano-Optomechanical Systems for ICT and QIPC,FP7,30 December 2011,01 October 2008,2267412.0 MINT,Technion Israel Institute of Technology,health,"The application of nanotechnology for addressing key problems in clinical diagnosis and therapy holds great promise in medicine and in cancer in particular. Recent works have shown significant progress in nanoparticle-mediated drug delivery and therapy. In these applications, however, the small dimensions of the nanoparticles have been used primarily for efficient delivery and specificity, while the effects mediated by the nanoparticles occur away from the particle itself, affecting the entire cell umour volume. We propose to study and develop, for the first time, a novel scheme for cancer therapy that treats cancer cells at nanoscale resolutions. Briefly, when noble-metal nanoparticles are illuminated with femtosecond laser pulses tuned to their plasmonic resonance, order-of-magnitude enhancements of the optical fields several nanometres away from their surfaces lead to local damage only to nearby molecules or cellular organelles. This process, which practically involves no toxic agents, is at the basis for this proposal; we will utilize techniques for targeting nanoparticles to cells, initiate and control cancer cell destruction using nanoparticles and femtosecond laser pulses, and develop technology for conducting image-guided minimally invasive cancer therapy in remote locations of the body. Preliminary results supporting the proposed scheme include nonlinear optical imaging and ablation of living cells, in vivo endoscopic imaging of cancerous tumour nodules, and computer simulations of light-nanoparticle interactions. Using state-of-the-art concepts in nanotechnology, biology, chemistry, and medicine, the proposed novel multidisciplinary research will attempt at offering a feasible and safe addition to existing forms of cancer therapy.",Multiphoton Ionization Nano-Therapy,FP7,30 November 2014,01 December 2009,1782600.0 MINT,IMDEA Nanoscience Institute * IMDEA Nanociencia,energy,"We present a plan to design, synthesize and exploit the properties of mechanically interlocked carbon nanotubes (MINTs). The scientific aim of the project is to introduce the mechanical bond as a new tool for the derivatization of carbon nanotubes. The mechanical link combines the advantages of covalent and supramolecular modifications, namely: kinetic stability (covalent) and conserved chemical structure (supramolecular). Besides this, its dynamic nature opens up unique opportunities for both fundamental studies and applications. From a technological point of view, MINTs should have a practical impact in the fields of molecular electronics and molecular machinery. A general modular approach to MINT-based materials for photovoltaic devices and electrochemical sensors is presented. We also expect to exploit the rigidity and low dimensionality of SWNTs to construct molecular machines that utilize them as tracks to move across long distances, which is not possible in small-molecule molecular machines. To achieve these goals we will exploit the PI's expertise in the chemical modification of carbon nanostructures, in the self-assembly of electroactive materials and in the synthesis and characterization of mechanically interlocked molecules.",Mechanically Interlocked Carbon Nanotubes,FP7,30 September 2017,01 October 2012,1444999.0 MINUET,Meggitt A/S,health,"MINUET's objective is to develop improved multifunctional, knowledge-based materials, new production processes and technologies for complex miniaturised functional structures and devices, based on electroceramics. WP1 Materials and WP2 Integrated Multimaterials Structures work closely together in WP1 on modelling of material properties as a function of compositions. In WP2, PZT, lead-free and the new modelled compositions will be used to adapt frontier technologies, as LTCC structures, opening an opportunity for complex miniaturised devices. Presently, LTCC includes only passive components due to high reactivity of piezoelectric thick films with substrates. Modelling results will be verified at laboratory scale through preparation of powders and components and testing their properties. Best compositions will be scaled up and samples delivered to the end users in traditional form and in thick-film structures. The best ones will be modified further to comply with LTCC. LTCC structures can replace bulk components leading to enhanced performance with more degrees of functionality in robotics and integrated sensors (WP5 Devices for Robotics). WP3 Devices for Fluidics and Optics covers work on nano-engineered structure for adaptive 'photonic crystals', tunable filters and printheads with discrete assemblies replaced by integrated structures. WP4 Devices for Acoustics covers medical, NDT and process control applications. Models are used to calculate material specifications for WP1 and WP2 and design prototype devices to verify the models and test performance. MINUET has a vertical structure from material modelling to small-scale testing of compositions and technology, scaling up and testing devices. The output is the verified model and technology of new materials, their integration into LTCC, devices based upon these and nano-engineered structures. High socio-economic potential results from reduced environmental impact by using less hazardous chemicals.","Miniaturised Ultrasonic, Engineered-Structure and LTCC-Based Devices for Acoustics, Fluidies, Optics and Robotics",FP6,31 October 2007,01 May 2004,2281175.0 MIR-OPTOFECTARRAY,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"Considerable focus has been placed on the influence of endogenous and exogenous interfering RNA on stem cell differentiation and behavior and substantial effort to elucidate the potential of reprogramming stem cells to guide of them towards a cardiomyogenic phenotype as a therapeutic option for heart disease. The majority of studies employ gain- or loss- of function experimental models or perform global microArrays to determine microRNAs that exhibit candidacy as governing dictators of differentiation. Delivery of these potentially therapeutic biomolecules can be achieved through viral vectors; which raises concerns of mutagenesis and immunogenicity, or their less efficient counterparts -non-viral vectors. The fellow presents here, the use of femtosecond laser Optotransfection to create transient nanopores in the cell membrane to allow entry of exogenous microRNAs efficiently into the cell with minimal effect on cellular viability. The fellow aims to apply this system in an automated process, combining robotics, software engineering and management of data in a multi-disciplinary project toward which he will add his expert knowledge in microRNA delivery in vitro, cardiac related microRNAs, in vitro cell culture and biomedical engineering. This project places the fellow in a unique position to apply biomedical research technology to an automated process to yield high-throughput standardized experiments which could yield potent formulations of microRNAs to reprogram stem cells towards a cardiac progenitor cell lineage. Herein, this project proposal describes the multidisciplinary nature of this project, the execution and management of this project by the fellow and the multiple collaborators that will each equip the fellow with cutting-edge research skills. The goals of the fellow's project will place specific focus to ensure that the training of the fellow brings him to a level of competitive scientific excellence both in Europe and Internationally.",Delivering non-viral silencing RNA (microRNA) using automated femtosecond lasers into stem cells for cardiac reprogramming and characterization using non-destructive optical techniques,FP7,31 July 2015,01 August 2013,168794.0 MIRANDELA,STMicroelectronics SA,information and communications technology,"The ENIAC JU project MIRANDELA is building a complete digital, mixed-signal, analogue, radio frequency (RF) and millimetre-wave (MMW) platform for the design and production of chips for future wireless communications to address the challenge of transferring anything, from/to anybody, anywhere, at any time and through any path. Components in core CMOS technology and other processes will be characterised, optimised and modelled in the RF and MMW range as well as for analogue operation targeting very low power design of RF blocks and functions. Solutions will be developed to cut costs and time to market.",Millimeter-wave and Radio-frequency integration in Nanoelectronics for Modern Wireless 5 A Communications,FP7,04 January 2013,05 January 2010,8212855.0 MIRNANO,Universiteit Maastricht * Maastricht University,health,"Engineered nanomaterials (ENM) are becoming an issue of great concern regarding their health effects. Different types of ENM are being used today in everyday consumer products as well as professional equipment such as medical devices. Several ENM, even those used in products that are already on the market, have been shown to be cytotoxic, genotoxic and immunotoxic in experimental settings, but knowledge is still too scarce and inconsistent for efficient and accurate risk assessment on ENM exposure and the materials are still classified according to the toxicity of their respective bulk material. Carbon nanotubes (CNTs) are among the most utilized ENM and studies have indicated that certain types may have similar health effects as the well-known human carcinogen, asbestos. The toxic effects of CNTs have been investigated at several levels, but the genetic mechanisms behind these effects are still largely unknown. Toxicogenomics investigates the multifaceted genomic responses to xenobiotic substances in biological systems on a genome-wide level. Thus, toxicogenomic studies may reveal the genomic changes related to CNT exposure and may give insight into the mechanisms behind their hazardous effects. In this study genetic features such as mRNA and microRNA expression changes as well as histone modification patterns will be profiled on a genome-wide level in a bronchial epithelial cell line following exposure to various carbon nanomaterials, including CNTs. Asbestos will be used as a positive control. This will enable the identification of early genomic changes which may elucidate the mechanism of action behind the cellular responses to these ENM and possibly reveal eventual toxic outcomes following exposure. Furthermore, the results are anticipated to lay a foundation for accurate risk assessment of CNTs.",Toxicogenomic studies on engineered carbon nanomaterials,FP7,31 August 2014,01 September 2012,191675.0 MIRNATHERAPYNBL,Vall d'Hebron Research Institute * Vall d'Hebron Institut de Recerca,health,"Neuroblastoma (NBL) is the most common solid tumor of infancy. Nearly 45% of all children with NBL are designated as high-risk patients and 60% of them die. Therefore, there is an urgent need to identify and target the molecular programs that are responsible for NBL aggressiveness, especially those that contribute to metastasis and resistance to chemotherapy. Recently, it has become evident that microRNAs (miRNAs) are deregulated in numerous diseases including cancer. Particularly in NBL, there is a global reduction of miRNA levels, especially in high-risk patients, and the expression of miRNA processing machinery components (i.e. Drosha, Dicer) impact on patient outcome. MiRNA restoration can be the basis for novel forms of therapy, by limiting the metastatic potential of NBL tumor cells and/or enhancing their sensitivity to current forms of treatment. The overall goal of my research will be to restore the levels of miRNA using a full miRNA library (ï¾1200 miRNAs) in highly chemoresistant NBL cells, and monitor the response with the miRNA alone or in combination with currently used chemotherapy drugs. The effect of the miRNA(s) will be validated in a expanded panel of NBL cell lines. Furthermore, we plan to develop a therapeutic tool based on nanoparticles, to target NBL cells in vivo and overexpress the target miRNA. Finally, the levels of those miRNA are going to be evaluated retrospectively in FFPE archived samples, in order to determine if the expression of a particular miRNA (or a signature) can be a biomarker of disease, indicator of minimal-residual disease or response to therapy and, correlation with overall or post-recurrence survival.",New epigenetic therapy for high-risk neuroblastoma,FP7,30 September 2017,01 October 2013,100000.0 ML²,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"Microfluidics and lab-on-chip is an enabling technology with great growth potential. The life science industry has come to realise the trends and potential of miniaturisation which already have effected the information and communication industry in the last decades. Combinations of microfluidics, microelectronics and microoptics provide striking opportunities for advancing biomedical research and creating new markets for the medical sciences industry. In terms of economical and ecologically worthwhile processes, complex Micro-Nano Bio Systems (MNBS) have greatest potential to enhance processes for cell-based assays, chemical analytics and medical diagnostics. However, there are three main challenges for such (MNBS) market to overcome which hamper growth of the market: First, a lack of economical micro-fabrication methods hamper the implementation of lab-on-chip solutions in an industrial scale. Second, inefficient interfaces between laboratory equipment and mircofluidic devices cause a lack of interoperability. Third, there is no integrated manufacturing platform which provides flexible and cheap design and re-design opportunities. ML² will overcome these three main challenges by developing a cost efficient production system for new generation MNBS, combining microfluidics, optics and microelectronics. The devices will base on a multi layer concept. The overall function of the smart device will be split in several subfunctions, which can be of fluidic, optical or electronic nature. Multiple foils will transfer the functionality into technical solutions. Economic roll-to-roll processes will be developed for the production of micro fluidic and optic functional layers. ML² will provide a design and manufacturing platform for the production of sophisticated devices which combine microfluidics, optics and microelectronics. ML² devices will compact devices with increased performance at lower prices compared to existing MNBS.",Design platform for economic production of multilayer Micro-Nano Bio Systems,FP7,31 August 2016,01 September 2012,7690995.0 MMFCS,Lund University * Lunds Universitet,energy,"In proton exchange membrane fuel cells (PEMFCs) and solid oxide fuel cells (SOFCs) there are various transport processes strongly affected by catalytic chemical/electrochemical reactions in nano- or/and micro-structured and multi-functional porous electrodes. Due to the complexity of fuel cells, fundamental understanding of physical phenomena continues to be required for the coupled chemical and transport processes with two-phase flow/water management in PEMFCs, and internal reforming reactions/thermal management in SOFCs. The project deals with the coupling of micro scale reactions (such as the electrochemical reactions and catalytic reactions) with various transport phenomena to provide a comprehensive understanding of fuel cell dynamics. The methodology for the project is a combination of model development and integration, simulation/analysis and validation. For microscopically complex porous layers and active sites, submodels will be developed by considering the detailed elementary kinetic rates based on the intermediate chemical species and their reactions occurring on the surface of the involved materials. As the inputs, the obtained data from the microscopic submodels will be implemented by the macroscopic CFD codes, previously developed for various applications, to examine local parameters in the porous electrodes and components. Both macro- and microscopic models will be validated by the experimental and/or literature data during the course of the project. The project will make progress beyond the state-of-the-art in modelling and analysis of advanced fuel cells, such as ultra low Pt loading (<0.1mgPt/cm2) and high temperature (120-200oC) PEMFCs, and intermediate temperature (600-800oC) planar SOFCs.",Multiscale Models for Catalytic-Reaction-Coupled Transport Phenomena in Fuel Cells,FP7,31 May 2014,01 June 2009,1320000.0 MMP,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,energy,"The high-tech industry strives to increase overall functionality and quality of products by the application of nano-enabled materials and devices. The development of such products would significantly benefit from a thorough understanding of multiscale phenomena and adequate numerical tools to guide nano-enabled design. The scientific challenge lies in defining proper scale transition relations to transfer data between the relevant scales and to properly address the mutually dependence of the multi-physics. Nano-engineering is intrinsically strongly multidisciplinary, thereby posing the technical challenge to assemble the, in generally, distributed expertise and simulation resources. MMP (Multiscale Modelling Platform) develops an integrating modelling platform, especially equipped to target multi-scale and multiphysics engineering problems. The innovation of MMP lies in its generic and modular character, supported by data standardization and proper definition of application interfaces. This allows for the integration of existing modelling software's and data repositories as plug-in components. MMP will be distributed as open source software supported by online documentation. This enables future users, e.g. SMEs, to join, contribute and benefit from MMP. The versatility and power of the platform is demonstrated by assessing two case studies on nano-enabled products with a high sustainability impact. The performance of phosphor light conversion in LEDs and the efficiency of CIGS thin film processing for photo-voltaics devices will be increased. MMP provides the European industry with a competitive advantage by allowing for an integrated process, material and product design. Multiscale modelling and therewith multiscale design will considerably reduce development costs, decrease time to market and improve process yield and device functionality. Moreover, the cloud computing strategy enables the optimal utilization of simulation facilities and facilitates collaboration.",Multiscale Modelling Platform: Smart design of nano-enabled products in green technologies,FP7,31 December 2016,01 January 2014,3339235.0 MN-LN SMMS,University of Cyprus,information and communications technology,"Nanoscopic magnetic materials are of increasing interest because of their potential use for ultrahigh – density information storage, quantum computing, sensing and biomedical applications. Among the various types of nanoscopic magnetic materials, single molecule magnets (SMMs) represent a family of promising, for use in the above mentioned technological applications, molecule – based magnetic materials. SMMs are molecular transition-metal clusters that retain their magnetization below a blocking temperature (TB or Tcritical) in the absence of an applied field. In order to employ molecule-based materials in technological applications it is important to prepare SMMs with larger thermodynamic barriers (U) and effective (kinetic) barriers (Ueff) to magnetization reversal and the synthesis of polynuclear heterometallic Mn/lanthanide (Ln) species seems an attractive approach for achieving this. The main idea behind this approach is to combine Mnn+ and Ln3+ ion’s significant spin and/or their large anisotropy to generate Mn/4f SMMs distinctly different from, and superior to, the homometallic ones. The specific scientific and technological objectives of this project include: 1) the preparation of new Mn-Ln-L (L = diol-type ligands) clusters and SMMs, 2) the development of new synthetic procedures to polynuclear Mn-Ln clusters and SMMs, and 3) the complete structural and magnetic characterization of the compounds. The complete magnetic and structural characterization of the compounds is essential in order to rationalize their magnetic properties on the basis of their structural characteristics and finally to achieve optimization of their SMM properties by performing controlled structural modifications.",Synthesis and characterization of Mn-Ln polynuclear complexes with interesting magnetic properties by the use of diol type ligands,FP7,12 July 2017,01 January 2012,100000.0 MNIBS,Technical University of Madrid * Universidad Politécnica de Madrid,health,"A multi-scale modeling study is proposed to develop a fundamental understanding of the segregation and self assembly of phospholipids and polypeptide amphiphiles at interfaces, and their interaction with liquid crystalline phases. The current study is motivated by recent experiments that indicate that liquid crystalline phases are capable of interrogating the structure of phospholipidic interfaces at the scale of nanometers, thereby providing a powerful tool for probing nanoscale structure, and providing the basis for development of sensors for biological molecules. This study is also motivated by experiments from the Stupp group that indicate that peptide amphiphile molecules self-assemble into highly organized structures whose interfaces provide an ideal substrate for cell growth.",Multiscale Modeling of Nanostructured Interfaces for Biological Sensors,FP6,31 August 2009,01 December 2005,780113.0 MNIQS,IMEP-LAHC Laboratory,information and communications technology,The purpose of the project is to study linear and nonlinear models arising in quantum mechanics and which are used to describe,Mathematics and Numerics of Infinite Quantum Systems,FP7,09 June 2017,10 January 2010,0.0 MOBILIS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"Digital Radio transmission for applications such as short distance radio links is coming closer to reality. A significant effort is however still needed to port Digital Radio to Cellular. The major bottleneck towards the 'software radio' is the high-frequency part of the radio transceiver. Analog-to-digital or digital-to-analog conversion right at the antenna is far beyond what state of the art technology is able to deliver. An alternative solution to bring the digital-to-analog interface closer to the antenna in the transmitter is using bandpass delta-sigma modulation. The reconfigurability of such a transmitter for multi-mode communication systems depends on the availability of appropriate high-power RF filters and on the reconfigurability of the power amplifier to address different bandwidths and power requirements. The objective of MOBILIS is two-fold: develop a robust and cost-effective integrated high-power RF filtering technology and demonstrate, based on that technology, the feasibility of a mixed SoC (nanometric CMOS/system integration) and SiP (BiCMOS/power-BAW) RF power transmitter. The targeted transmitter is based on a Digital Radio transmitter architecture and addresses both the WCDMA and DCS standards. To reach this objective, a series of intermediate technological objectives will be achieved: - Investigation of above IC integration of new materials on 200 mm wafers, - Investigation of the power handling capabilities of the BAW technology, - Development of a new non-linear SMR-type BAW model, - Implementation of the new model in a CAD software for power-BAW filter design, - Integration of two band filters on the same wafer, - Development of a reconfigurable power amplifier, - Development of integrated test-benches at the circuit and system levels. The MOBILIS project addresses one strong element of the IST call which is Nanoelectronics.",Mixed SiP and SoC Integration of Power BAW Filters for Digital Wireless Transmissions,FP6,30 June 2009,30 December 2005,2956623.0 MOCAPAF,University of Helsinki * Helsingin Yliopisto,environment,"Climate change is currently one of the central scientific issues in the world, and the ability to reliably forecast climate is crucial for making political decisions that affect the lives of billions of people. Aerosols remain the dominant uncertainty in predicting radiative forcing and future climate change, and also have adverse effects on human health and visibility. One of the least-well understood aerosol-related processes is nucleation: the formation of new particles from condensable vapours. While nucleation is related primarily to neutral clusters, state-of-the-art experimental methods measure only charged clusters.",Role of Molecular Clusters in Atmospheric Particle Formation,FP7,01 July 2018,02 January 2011,0.0 MOCNA,IMEP-LAHC Laboratory,photonics,"The project aims at magneto-optical spectroscopy studies of carbon nano-allotropes: graphene, individual nano-tubes and graphene nano-ribbons. The main objective of the project is to explore the new fundamental phenomena by studying the structures which are among the most promising ones for development of future nano-technologies. Understanding the properties of these systems will certainly have the impact on the effectiveness of their applications. The project consists of three specific parts. The first one focuses on investigations of electron-phonon interaction and collective modes of electronic inter Landau level excitations in graphene flakes, using the methods of magneto-Raman scattering. These interactions are one of the central points of graphene, seen as unconventional two-dimensional electronic system. The second part aims at deeper understanding of the exciton structure and its excited states in single wall carbon nanotubes. Ensembles of nanotubes and furthermore individual objects will be studied using various magneto-spectroscopy techniques. To this end, the measurements of single photon-correlation are planned in order to identify correlations between different excited states characteristic of the carbon nanotube. The third part of the project, of exploratory character, is focused on searching for the evidence of the reduced dimensionality in the spectroscopy of artificially obtained graphene nanoribbons. The new structures will be first characterized using the micro-Raman spectroscopy (basic phonon mode of graphene is expected to be modified by the reduced size of the stripe), and eventually studied using other magneto-spectroscopy methods. These experiments may be used to verify the theoretical predictions concerning the properties of these, very much demanded systems.",Magneto-optics of carbon nano-allotropes,FP7,31 January 2011,01 February 2009,233164.0 MOD-ENP-TOX,University of Leuven * Katholieke Universiteit Leuven,environment,"MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modeling Package (CMP) based on structural, mechanistic, as well as kinetic modeling tools and (2) an innovative high content screening (HCS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.","Modeling Assays Platform \"MAP\" for hazard ranking of engineered nanoparticles (ENPs)",FP7,12 July 2017,01 January 2013,0.0 MODENA,Norwegian University of Science and Technology * Norges Teknisk-Naturvitenskapelige Universitet (NTNU),transport,"MoDeNa aims at developing, demonstrating and assessing an easy-to-use multi-scale software-modelling framework application under an open-source licensing scheme that delivers models with feasible computational loads for process and product design of complex materials. The use of the software will lead to novel research and development avenues that fundamentally improve the properties of these nanomaterials.",Modelling of morphology Development of micro- and Nano Structures,FP7,12 July 2018,01 January 2014,0.0 MODERN,STMicroelectronics SA,information and communications technology,"The influence of process variations is becoming extremely critical for nanoCMOS technology nodes, due to geometric tolerances and manufacturing non-idealities (such as edge or surface roughness, or the fluctuation of the number of doping atoms). As a result, production yields and figures of merit of a circuit such as performance, power, and reliability have become extremely sensitive to uncontrollable statistical process variations. Although some kind of variability has always existed and been taken into account for designing integrated circuits, the largest impact of variability and the greater influence of random or spatial aspects are setting up a completely new challenge. On top of those difficulties, the deficiency of design techniques and EDA methodologies for tackling PVs makes that challenge even more critical.","MOdeling and DEsign of Reliable, process variation-aware Nanoelectronic devices, circuits and systems",FP7,02 January 2012,03 January 2009,0.0 MODERN,Rovira i Virgili University * Universitat Rovira i Virgili,environment,"Nano-sized materials are a common element in many industrial processes mainly due to their unique properties that lead to the production of high technology products. The widespread use of nanotechnology requires the consideration of the environmental and human health risks that may result from the introduction of engineered nanoparticles (eNPs) into the environment. Although toxic effects for certain types of eNP have been recently reported, there is still a lack of knowledge about their possible long-term effects in biological systems.",MODeling the EnviRonmental and human health effects of Nanomaterials (MODERN),FP7,12 July 2017,01 January 2013,0.0 MODNANOTOX,University of Birmingham,environment,"ModNanoTox will develop a number of well-documented and technically advanced models describing the behaviour of engineered nanoparticles in organisms and the environment. Background to these models will be a thoroughly documented database, constructed based on: (1) an advanced evaluation of physicochemical properties of nanoparticles and in silico modelling of their reactivity; and (2) assessment of the characterisation methodologies as well as toxicity protocols used to develop biological responses in toxicological studies. At the next level whole datasets will be evaluated for internal consistency and then compared with other relevant sets. The evaluation stage will be followed by development of toxicity models based at the individual organism level, using statistical and mechanistic models, in parallel with models predicting environmental fate. The toxicity and fate models will be integrated in mechanistic models to predict the long term risks of engineered nanoparticles for populations under realistic environmental conditions. The risk assessment models will be developed in close collaboration with appropriate stakeholders and end users to ensure their suitability for practical use in relevant legislative contexts.","Modelling nanoparticle toxicity: principles, methods, novel approaches",FP7,10 July 2015,11 January 2011,999899.0 MOEBIUS,TUT Foundation - Tampere University of Technology * TTY-Säätiö - Tampereen Teknillinen Yliopisto,environment,"The main objective of the project is to bring together recent advances in semiconductor nanostructures, organic molecule self-assembling and bio-interfacing to develop a new generation of biosensors for in situ environmental monitoring and life science applications. Tunable electronic material with pores on semiconductors produced by swift heavy ion-track-based patterning forms an attractive foundation for interfacing conventional electronics with bio-active sensor compounds. Nano-sized channels of ion-track based structures modified by metal oxides in combination with a self-assembled layer of organic or bio-organic sensor layer can multiply the response of the device by many orders of magnitude as compared to conventional sensor architecture. Thus the fundamental goals of the project are nanofabrication of such state-of-the-art structures and exploring of the interactions between bio-molecules and novel nanomaterial.",Multifunctional Organic-inorganic Elements with Biosensing re-Usability,FP7,01 August 2013,01 September 2012,0.0 MOEBIUS,South Ukrainian K. D. Ushynsky National Pedagogical University,environment,"The main objective of the project is to bring together recent advances in semiconductor nanostructures, organic molecule self-assembling and bio-interfacing to develop a new generation of biosensors for in situ environmental monitoring and life science applications. Tunable electronic material with pores on semiconductors produced by",Multifunctional Organic-inorganic Elements with Biosensing re-Usability,FP7,01 February 2015,01 March 2014,0.0 MOLD-ERA,ASM - Ghitu Institute of Electronic Engineering and Nanotechnology * Bine aţi venit la Institutul de Inginerie Electronica şi Nanotehnologii,health,"The objective of MOLD-ERA is to assist the Institute of Electronic Engineering and Nanotechnologies (IEEN) to develop and implement a research strategy that will expand its activities and increase its level of excellence, so that it can compete and collaborate with leading research institutions in Europe. MOLD-ERA training activities will be opened up and integrate with activities in other relevant research institutions in Moldova to increase the project impact and thereby increase the generation of wealth in the region. Focus is on a new research and training program for young researchers that will result in creation of a leading European infrastructure at IEEN in nanotechnology and nanobiology. This will be implemented through: - Combining existing facilities at IEEN in the field of Nanotechnology with new equipment to be purchased to extend this research area to Nanobiology with a focus on the properties and structure of complex assemblies of biomolecules, such as biochips, molecular motors and membrane assemblies in conjunction with the distinctive surfaces, rods, dots and materials of nanoscience. - Establishment of a nanobiology training program to integrate the principles of nanoscale science and biology in research and coursework for the development of a new generation of nanobiologists. This will include (i) theoretical courses for PhD and Master students in the fields of biocompatibility of electronic and photonic materials, transformation of bio-signals in electric signals and vice-versa, extra and intracellular bioelectric signaling, biotoxicity and related disciplines; (ii) practical training of young researchers from the IEEN at leading European research centres in the areas of nano-bio, nano-medicine etc. - Training modules will be provided to assist researchers and staff from across Moldova to attain a more efficient and practical understanding of FP7 rules and regulations and receive training to increase success in submitting FP7 proposals.",Preparation for Moldova's integration into the European Research Area and into the Community R&D Framework Programs on the basis of scientific excellence,FP7,30 April 2013,01 November 2010,498888.0 MOLD-NANONET,Institutul de Cercetări Stiinţifice ELIRI SA,energy,"The objective of MOLD-NANONET is to assist the ELIRI Research Institute to develop and implement a research strategy that will expand its activities and increase its level of excellence in micro-nano-electronics related to the development of intelligent systems, so that it can compete and collaborate with leading research institutions in Europe. MOLD-NANONET will create a unified infrastructure in Moldova by integrating the R&D capabilities of the city of BELTI with those of the capital city (Chisinau). Training activities will be opened up and integrate with activities in other relevant research institutions in Moldova and with the new Technological Park affiliated to ELIRI. MOLD-NANONET will stimulate the creation of a bridge between applied research and innovative business. Focus is on a new research and training program for young researchers at ELIRI and BELTI in integrated nanostructure networks for implementation in intelligent systems. This will be realized through: - Combining existing facilities at ELIRI in the field of micro-nano-technology with new equipment to extend the expertise to integrated networks of nanostructures based on magnetic, thermoelectric and shape memory metals for applications in intelligent systems based on synergetic integration of nanoelectronics, fine mechanics, product design and soft development. - Establishment of a training program to integrate the principles of nanoscale science in research and coursework for the development of a new generation of experts at the intersection of nanoelectronics, fine mechanics, product design and soft development. - Training modules to teach Master and PhD students how to promote a new technology, novel material or device to the market via technology transfer based on innovation. - Training modules will assist researchers and staff from across Moldova to attain a practical understanding of FP rules and regulations and receive training to increase success in FP proposals.",Enhancing the capacities of the ELIRI Research Institute in applied research to enable the integration of Moldova in the European Research Area on the basis of scientific excellence,FP7,31 May 2014,01 December 2011,474999.0 MOLDY,Trinity College Dublin,health,"Trinity College Dublin has world class research scientists working the in fields of experimental and theoretical nano-sciences (nano-phyiscs) and experimental life sciences (including bio molecular modelling, protein folding, compound screening and drug discovery/delivery systems). The University is recognised for its strong research capabilities in the areas of high performance computing and algorithm design in the physical and biological sciences. Terascale computating with storage facilities, and immersive visualisation facilities will be an integral part of the consolidation of the computational scientists in the new Information Technology and Advanced Computing programme in Trinity.Trinity has identified a gap in the multidisciplinary competencies of the University between these two exciting areas of research. The objective of this proposal is to strengthen the bridge between these two competencies and to provide new validated molecular dynamics simulation tools to enhance the research capabilities of the bioscience and nanoscience groups. This objective will be achieved by transferring the experience of experts to assist in identifying the needs of these scientists and working with local researchers to customise existing molecular dynamics packages to meet their requirements. The work will lead to faster, more efficient MD calculations in the Nano/Life sciences. The close interaction in Trinity between the bio/nanoscientist and computational science groups is somewhat unique in Europe. This programme will offer the external researchers access to real data in order to validate software tools. Visiting researchers will be invited to participate in the post graduate teaching programme and to get involved in the variety of outreach activities organised by the University on a yearly basis.",Molecular Dynamics Simulation Tools,FP6,31 July 2009,01 August 2006,455092.0 MOLECSYNCON,Rijksuniversiteit Groningen * University of Groningen,information and communications technology,"This project pushes Molecular Electronics (ME) beyond simple distant-dependence studies towards controlling tunneling charge transport with organic synthesis by manipulating the intrinsic properties of organic molecules to shape the tunneling barrier. The measurements will be done with two tools that I have developed; Eutectic Ga-In (EGaIn), which is increasingly being used by the ME community as a robust method for measuring charge-transport through self-assembled monolayers (SAMs) and SAM-templated nanogap (STAN) electrodes, which is a newer tool that allows the facile coupling of light and electric fields into SAM-based tunneling junctions. These tools are critical for performing physical-organic studies in practical tunneling junctions in which the molecules themselves define the smallest dimension of the junction; spectroscopic tools that rely on AFM or STM define the junction with a piezo and are not directly applicable to practical devices, which is the underlying motivation for all research in ME.",Controlling Tunneling Charge Transport with Organic Synthesis,FP7,07 July 2020,08 January 2013,0.0 MOLESCO,Durham University,information and communications technology,"The MOLESCO network will create a unique training and research environment to develop a pool of young researchers capable of achieving breakthroughs aimed at realising the immense potential of molecular electronics. In part this will involve the major challenges of design and fabrication of molecular-scale devices. To deliver this step-change in capability, MOLESCO will coordinate the activities of internationally-leading scientists from six different countries. MOLESCO has secured the participation of nine private sector partners, including one of Europe’s leading industrial electronics-research laboratories (IBM Research–Zurich) as a full partner. A highly-integrated approach to the experimental and theoretical aspects of molecular-scale electronics will deliver the fundamental knowledge and new fabrication strategies needed to underpin future nanotechnologies targeted for electronics applications. MOLESCO represents a highly interdisciplinary and intersectoral collaboration between teams with an extensive portfolio of skills, including molecular synthesis, fabrication of molecular junctions, imaging of molecular junctions with atomic resolution, measurements of charge transport, and electronic structure and transport calculations. Training will be delivered in a series of high-priority actions primarily aimed at providing the researchers with an outstanding career development platform. The network has a strong focus on interdisciplinary training; it is built on several well-established and fruitful collaborations between the partners and seeks to bridge an existing educational gap in the European Research Arena. The development of complementary skills (presentation, management, technology transfer, IP protection, outreach and intersectoral training) will be implemented throughout the lifetime of the project. Specialist professional training in dissemination and outreach will be delivered by our Associate Partner BLP, a professional media production company.","MOLECULAR-SCALE ELECTRONICS: Concepts, Contacts and Stability 'MOLESCO'",FP7,12 July 2019,01 January 2014,3985376.0 MOLMAG,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),information and communications technology,"In the era of nanotechnology molecular magnetism is experiencing a large and increasing interest since the observation that molecules can behave like magnets, thus representing the ultimate step in the process of miniaturization of magnetic memories. Moreover magnetism is relevant to such diverse field as solid state physics and biology and recently the impact of chemistry has dramatically increased with the development of molecular magnetism. To provide training in this field means learning techniques, such as magnetometry and EPR, which can be used in the different scientific areas beyond the field of nanosciences. The research training will allow the fellows to use state-of-the-art apparatus for magnetic measurements and EPR spectroscopy. In particular they will use a continuously up-dated High Field High Frequency EPR spectrometer (12 T up to 1 THz) one of the few existing in the world, together with 95 GHz W-band, X-band and Q-band spectrometers. HF-EPR spectroscopy is rapidly developing and is promising to allow to record spectra of systems which so far have been EPR-silent. These techniques will be applied to molecular magnets and metalloproteins. The fellows will learn how to analyze and rationalize the experimental results using several different theoretical tools, ranging from spin Hamiltonian to DFT approaches. At the end of the training the fellows should be able to correlate the magnetic properties of the systems of their interest with their structures. The Florence laboratory is a world leader in molecular magnetism, especially in the use of magnetic resonance and magnetic measurements for investigating single molecule magnets, molecular based materials and metalloproteins. The applicants should preferably have a background in physical, inorganic, bioinorganic or organic chemistry, or in physics and attitude to experimental work strongly backed to theory. Applications from women and people from less favoured regions are strongly encouraged.",Magnetism and Magnetic Resonance of Molecules,FP6,31 August 2008,01 September 2004,266490.0 MOLMESON,University of Regensburg * Universität Regensburg,health,"This project explors the boundary between the individual molecule and the bulk solid in the context of polymeric organic semiconductors by constructing and studying molecular aggregates from the single molecule level upwards. Using time-resolved and steady-state spectroscopies at elevated and at cryogenic temperatures, the interaction of individual molecular units will be revealed. For example, the question arises as to how large a molecular aggregate can become to still behave as an individual quantum-mechanical entity, emitting just one photon at a time. How far can photoexcitations migrate in self-organized mesoscopic aggregates, and what is the interaction length with quenching species such as charges? Under which conditions does the coupling between molecular units weaken to become incoherent and irreversible? The work program combines routes to controlling self-assembly in-situ and monitoring conformational dynamics of the polymer chain as well as aggregation effects in real-time. Superresolution microscopic techniques will be applied to spatially localize excitations on a polymer chain and watch their migration. Single-molecule fluorescence will be combined with spin-resonance techniques to study charge formation und unravel radical-based material breakdown processes. Besides this bottom-up control of spectroscopic features, a top-down approach to device engineering will be explored with the goal of identifying the smallest-possible device features below which the effects of discreteness dominate leading to single-electron and single-photon devices. Breakthroughs with implications beyond organic electronics are anticipated, since the materials provide models for polymer physics, quantum optics and solid-state mesoscopics. Sensory functions are expected to derive from the control and understanding of light-matter interactions on super-molecular sub-ensemble length scales.",Molecular Mesoscopics for Organic Nano-Optoelectronics,FP7,30 November 2017,01 December 2012,1480555.0 MOLNANOSPIN,IMEP-LAHC Laboratory,information and communications technology,"A revolution in electronics is in view, with the contemporary evolution of two novel disciplines, spintronics and molecular electronics. A fundamental link between these two fields can be established using molecular magnetic materials and, in particular, single-molecule magnets, which combine the classic macroscale properties of a magnet with the quantum properties of a nanoscale entity. The resulting field, molecular spintronics aims at manipulating spins and charges in electronic devices containing one or more molecules. The main advantage is that the weak spin-orbit and hyperfine interactions in organic molecules suggest that spin-coherence may be preserved over time and distance much longer than in conventional metals or semiconductors. In addition, specific functions (e.g. switchability with light, electric field etc.) could be directly integrated into the molecule. In this context, the project proposes to fabricate, characterize and study molecular devices (molecular spin-transistor, molecular spin-valve and spin filter, molecular double-dot devices, carbon nanotube nano-SQUIDs, etc.) in order to read and manipulate the spin states of the molecule and to perform basic quantum operations. MolNanoSpin is designed to play a role of pathfinder in this still largely unexplored - field. The main target for the coming 5 years concerns fundamental science, but applications in quantum electronics are expected in the long run. The visionary concept of MolNanoSpin is underpinned by worldwide research on molecular magnetism and supramolecular chemistry, the 10-year long experience in molecular magnetism of the PI, his membership in FP6 MAGMANet NoE, and collaboration with outstanding scientists in the close environment of the team. During the last year, the recently founded team of the PI has already demonstrated the first important results in this new research area.",Molecular spintronics using single-molecule magnets,FP7,10 July 2015,11 January 2008,2096703.0 MOLOC,University of Liège * Université de Liège,information and communications technology,"MOLOC – Molecular Logic Circuits seeks to design and provide demonstration of principle, feasibility and significant advantages of logic circuits where the basic element is a single molecule (or assemblies of atoms or molecules) acting in itself as a logic circuit. The functionalities provided by this new post-Boolean approach differ in essential ways from using a molecule as a switch. The approach depends on molecules (or nanostructures, etc) having internal degrees of freedom and multiple (quasi)stationary states by virtue of their confined size. We therefore make an advantage of the nanosize which is imposed by the cardinal technological need to reduce the size of the circuit in order to implement complex logic functions at the hardware level and thereby add new functionalities. Exploratory work has shown that it is possible to address the states of a single molecule either electrically (or electrochemically) or optically and also that it is possible to concatenate the logic operation of two molecules. The partners to MOLOC are cognizant that to go beyond the projected limits of CMOS technology will likely be most productive if it be a surface based approach. All the same, foundational work in the gas or liquid phase is also discussed._x000d_",Molecular Logic Circuits,FP7,01 July 2013,02 January 2008,0.0 MOLS@MOLS,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"Because of their internal structure, molecules provide novel functionality not realizable in conventional semiconductor-based electronics. One exciting new possibility is that of spintronics: electronic devices using the electron spin to carry and manipulate information. So far, spintronics has been explored in metals and semiconductors. Magnetic molecules in principle enable radically new approaches in using the spin degree of freedom, but their incorporation in solid-state devices is a daunting task. In particular, the main challenge is to control their spin for storing and reading information. We propose to use electric fields and light for this purpose.",Controlling Molecular Spin at the Molecular Scale,FP7,03 July 2020,04 January 2013,0.0 MOLSPINTRON,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,information and communications technology,"Molecular spintronics is emerging as a rapidly growing field at the interface of inorganic molecular chemistry, surface sciences, and condensed matter physics fueled by both the fundamental interest in the underlying charge and spin transport mechanisms, and the prospects of the combined exploitation of molecular charge and spin states in a revolutionary new class of molecular-based ultra-low power devices translating their spin/charge response characteristics into novel, non-trivial functionalities. The research project proposes a range of innovative synthetic functionalization strategies of magnetic molecules that allow for targeted multi-terminal contacting of individual molecules in an approach representing a paradigm shift from existing top-down contact techniques in molecular spintronics. The project aims to reverse this existing approach and focuses on multi-step growth, controllable at the molecular level, of metallic electrode structures directly originating at a molecular magnet, as well as on controlled anchoring of the magnetic molecules to metal oxide surfaces of gate electrodes. Central to the proposal are magnetically functionalized polyoxometalates which provide a range of advantages relevant to molecular spintronics such as high stability, redox activity, structural versatility, tuneability of their molecular magnetic structures, as well growth strategies of metallic nanostructures such as quantum size-effect-controlled growth of metallic island structures. The synthetic expansion of molecule-attached metal nanocluster precursor structures into functional multi-terminal contacts addressable by multi-tip STM setups will lead to a breakthrough in reproducible charge transport measurements of single magnetic molecules and access to their fascinating Kondo physics, while the targeted technological breakthrough targets a chemically controlled integration of single magnetic molecules into nanostructured environments of spintronic devices.",Synthetic Expansion of Magnetic Molecules Into Spintronic Devices,FP7,10 July 2019,11 January 2012,1467200.0 MOLYCELL,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"Organic solar cells promise a strong cost reduction of photovoltaics (PV) if fast improvements of the power efficiency and the lifetime can be achieved. There are still some crucial obstacles to overcome before a large-scale production of plastic solar cells can be considered. The latter is the clear aim of all industrial partners here involved. The feasibility of this approach will be proven with a new generation of organic PV having better efficiency ( 5% on 1cm2 glass substrate and 4% on 1cm2 flexible substrate), longer lifetime and a production cost far below those of competing technologies based on silicon. To reach this goal, the following questions will be worked out in parallel: 1. Design and synthesis of new materials to overcome the large mismatch between the currently available polymer materials absorption characteristics and the solar emission spectrum and also to improve the mediocre charge transport properties. 2. Development of two device concepts to improve efficiencies: all-organic solar cells and nanocrystal/organic hybrid solar cells : All-organic solar cells will be based on donor-acceptor bulk heterojunction built by blending of two organic materials serving as electron donor (hole semiconductor, low band gap polymers) and electron acceptor under the form of an homogeneous blend and sandwiching the organic matrix between two electrodes. One of these electrodes is transparent and the other is usually an opaque metal electrode. Two concepts will be developed to improve efficiencies: a) an innovative junction concept based on the orientation of polar molecules and b) a multi-junction bulk donor-acceptor heterojunction concept.Nanocrystal/organic hybrid solar cells will be based upon solid-state heterojunctions between nanocrystalline metal oxides and molecular/polymeric hole conductors. Two strategies will be addressed for light absorption: the sensitisation with molecular dyes and the use of absorbing polymeric hole conductors.","Molecular Orientation, Low Band Gap Materials and New Hybrid Device Concepts for the Improvement of Plastic Solar Cells (MOLYCELL)",FP6,30 June 2006,01 January 2004,2499967.0 MOMO,Research Center Plast-optica * Centro Ricerche Plast-optica SpA,transport,"The principal aim of this project is the study and development of tailor made multicomponent polymeric blends coming from post-industrial rejects, suitable to embed nanoparticles. The novel materials will be addressed to multisectoral applications such as lighting, automotive, textile and buildings, using different technologies such as injection moulding, fibre spinning and extrusion. The task will be accomplished through the integration of molecular modelling in rational design process, considering main aspects which characterise the development of novel materials: characteristics expected, components to gain the desired properties, technologies available to process materials. In a context of sustainability, up-grading post industrial rejects goes beyond simple re-use and aim to obtain eco-designed materials from sources that actually represent a production cost and are a waste problem. Through nano particles embedding, polymers matrices reaches high level of competitiveness towards raw materials. Project will investigate aspects regarding micro-nano phase behaviour of matrices themselves, interfaces between nano materials and matrices to obtain thermal resistance and stability, combined with transparent aspect and mechanical resistance, which are basic for the applications named before. Project will explore also how injection moulding, extrusion, and fibre spinning technologies can respond to the need of an economic way to process novel composites. The consortium consists of 10 partners from 3 different EC states, 2 different AC and 1 Mediterranean country). Universities (4), Research institutes (2), and SMEs (4) are represented in the team. In particular the project will considerably contribute to strengthen ERA bringing together researchers from east Europe and Mediterranean country with EC states.",INNOVATIVE MOLECULAR MODELLING APPROACH TO UP-GRADE POLYMERIC MATERIALS FROM POST INDUSTRIAL REJECTS,FP6,31 December 2006,01 January 2004,1250000.0 MONA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),photonics,"Microelectronics and Photonics are two of the most important key enabling technologies for the markets of the 21st century. They influence our entire life and are technological drivers for multi-billion industry sectors such as automotive, telecommunication, life sciences, information technologies, sensing or industrial production by providing key components and applications. The MONA project will contribute to the coordination of photonics research with nanotechnology research. There are three principal objectives: � Create a common site for the exchange of information concerning research, networks of excellence, and integrated projects in photonics and nanotechnologies. � Promote the timely exchange of scientific results, market development, and technology needs through MONA-developed workshops. � Develop a European roadmap for photonics and nanotechnologies. The MONA project will coordinate FP-6 RandD programmes with relevant industries, with regional and national research programmes inside and outside Europe. Both photonics and nanotechnologies are highly multi-disciplinary fields, first from the point of view of applications, but also from the point of view of the enabling manufacturing tools and materials. The development of a viable commercial market will require a co-ordinated growth of science/technology, applications, and fabrication equipment/procedures. The Workpackages address: materials, technologies for manufacture, marketing, two-way relationships and exchanges with other nanotechnology research programmes, and a dissemination programme that emphasizes effective communications both inside and outside FP-6. The consortium consists of RandD laboratories, industry leaders and strategic planning organizations, with a broad complementarity and European coverage. This will ensure the building of a strategic comprehensive approach for the key technologies in order to shape the future of this highly important area for the European Union.",Merging Optics and Nanotechnologies,FP6,30 November 2007,30 May 2005,953988.0 MONACAT,Consejo Superior De Investigaciones Científicas (CSIC),environment,"This project aims at the preparation and testing of catalyst supported on structured reactors (ceramic and metallic honeycomb monoliths, metallic filters, carbon cloth) coated with nanocarbon materials (NCM), namely carbon nanofibers (CNF) and carbon nanotubes (CNT). This structured catalytic reactor will be used for catalytic water purification. Every partner responsible for testing the monoliths will focus on a different pollutant (Nitrates, organic matter…) and catalytic process (hydrogenation, oxidation) depending on the particular expertise of every partner. The properties of monolithic reactor coated with NCM, e.g. thin catalyst layer and mesoporosity, enable the control of the diffusion path and enhance the diffusion of reactant to catalytic sites. The objective is to achieve, via the use of monoliths coated with NCM, an intensification of the catalytic process in terms of improved selectivity, robustness, stability and performance while reducing energy requirements and by-product generation with respect to the catalytic process using conventional reactors, as e.g. trickled bed or slurry",Monolithic reactors structured at the nano and micro levels for catalytic water purification,FP7,04 June 2014,05 January 2009,1950097.0 MONAD,University of Liverpool,health,"The MONAD project will focus on the design, fabrication and implementation of dynamic nanodevices based on the purposeful interaction of nano-structured surfaces and nano-objects with protein linear molecular motors - ubiquitous biological nano-machines responsible for biological functions as diverse as cell movement and division, transport of vesicles and muscle contraction. The project will develop novel hybrid nano-bio-devices which will allow (i) quasi-immediate diagnostics, compared with the present hours-long response time; (ii) entirely new, efficient high throughput drug discovery for critical diseases, e.g., cancer; and (iii) new methodologies to study the information storage and processing processes in individual cells, with wider impact on medicine and health care industry. This high level of inter-disciplinary innovation will lead to further future new industrial applications, such as immediate, personalised diagnostics. The research consortium will undertake the whole innovation path on molecular-motors based devices, starting from fundamental science to the implementation of the research in demonstration devices for health care and industry. We can pursue this comprehensive science, technology and engineering knowledge transfer because of the existing synergism within the consortium between academia, research institutes and industry. In the context of NMP-2008-1.1-1 the MONAD project will advance the development of protein molecular motors-based devices, well beyond the state of the art, leveraging on, consolidating, and making sustainable the already commanding position of European research in this very specific, paradigmatic-shift emerging area. On a more general level, MONAD will advance and consolidate the high added value of European biomedical industry in the global world market, as well as providing a new high-added value economic rationale to the excellent European semiconductor device knowledge and capability.",Molecular Motors-based Nanodevices,FP7,30 September 2012,01 October 2009,2646773.0 MONARCH,Vivid Components Ltd.,manufacturing,"The technological objective of MONARCH is to produce the world????'s first scanning electron microscope (SEM) on-a-chip. Such an instrument would represent a step-change in electron beam (e-beam) technology comparable with the introduction of the silicon chip to electronics. This device will be orders of magnitude smaller than existing technology, would operate at lower voltages and have an order of magnitude higher resolution for a fraction of the cost of a current state-of-the-art SEM. It would provide the first instrument capable of rapidly scanning a surface layer and producing an image with elemental identification at atomic resolution. This disruptive technology has dramatic implications for many sectors other than electron microscopy, including e-beam lithography, genetic sequencing, ultra-high density data storage and focussed ion beam milling. In particular it is expected to be a key enabling tool for the booming sectors of nanotechnology and MNEMS (micro-nano-electromechanical systems). Crucially it could also allow lithography on a scale suitable for true nano-electronics.The physics behind the MONARCH project are beautifully simple: by scaling the device dimensions down to the nano-scale, the voltages, beam energies and aberrations are scaled down proportionally. The system becomes diffraction-limited, rather than aberration-limited, and the lenses can be electrostatic rather than magnetic. These principles have been known for decades, but the realisation of such devices has only been made possible through very recent parallel advances in several nano-machining technologies: improved FIB techniques, the evolution of MEMS technology and scanning probe microscopy (e.g. very short focal length electrostatic lenses). In short these techniques have transformed a thought-experiment into a realistic possibility: ultra-low energy, ultra-high power, ultra-pure e-beams.MONARCH will deliver a prototype operational integrated SEM-on-a-chip system.",Ultra-bright nanoscale SEM-on-a-chip,FP6,30 June 2009,01 January 2007,1391898.0 MONCERAT,University of Leuven * Katholieke Universiteit Leuven,transport,"Ceramics have an established market in industrial applications like metal forming, machining and some mechanical components. Most ceramics are prepared by conventional powder metallurgy (PM) and about 60 % of all components need some kind of post sintering machining operation. Electro Discharge Machining (EDM) is a process that could machine these hard materials, providing that the ceramics have a sufficiently high electrical conductivity. The major advantages of EDM are the accurate machining and the ability to produce complex shapes. Although some ceramic materials can be machined by EDM (e.g. TiN, TiC,..), the EDM process and ceramic materials have never been co-developed for each other. The MONCERAT project aims the research in the development of new electro-conductive ceramic materials as well as the development of new EDM generators. An important aim of the MONCERAT project is to gain a basic understanding on the interaction between the ceramic material (e.g. microstructure) and the EDM machining process. Further, the project aims to study how material properties of EDM'd ceramic components can be integrated into the design phase. The production of new ceramic materials will be partially based on the use of high quality nano-powders produced by the SHS process (Self propagating High Temperature Synthesis). The MONCERAT project expects a large potential impact on the use and development of ceramic materials for automotive, aerospace, machine tool, process engineering, health care, biomedicai, wear, micro-mechanics and environmental applications. The consortium consists of 11 partners from 5 European countries. The uniqueness of the MONCERAT project is the strong co-operation between ceramic material producers, EDM machine builders and potential users (all SME's) of ceramic materials in order to extend the fundamental knowledge, needed to developed the ceramic materials of the future that can optimally be shaped by EDM.'","Broadening the application field of ceramic components by joint and interactive research on EDM machining technology, novel ceramic materials based on nano-powders made by SHS and design methodology",FP6,30 June 2007,01 January 2004,2298963.94 MONINTERFLUOPROT,Pavol Jozef Safarik University * Univerzita Pavla Jozefa Šafárika v Košiciach,health,"At present, fundamental questions in biomedical translational research require the use of non invasive nanometer resolution techniques that facilitate the study of cell structure and function in vivo. The proposed project is highly interdisciplinary: it encompasses advanced research techniques in biophysics, cell physiology, and molecular biology. The long term aim of the project is to establish a cutting-edge multidisciplinary program in biomedical and translational research at the Department of Biophysics at the P.J. Å afárik University in KoÅ¡ice, Slovakia. The foundation of this program is laid out within EU structural fund projects CEVA I and II and SEPO I and II. The applicant, Dr. Stroffekova has advanced knowledge of cell physiology and biophysics, and was therefore approached to participate in the design and planning of the infrastructure for above mentioned EU projects, and to carry on her further research at the Department of Biophysics. The specific objectives of the present project are to introduce new research methodologies that will be used within infrastructure and to expand the scientific potential at the Department of Biophysics. Specifically, the project will introduce and establish electrophysiological measurements by whole cell patch clamp, site-directed mutagenesis and creation of fluorescent fusion proteins (FFPs) for application in confocal microscopy and fluorescence resonance energy transfer (FRET) measurements, and immunocytochemistry. All these methodologies will be used in novel approach to quantify the onset and modulation of apoptosis by FFPs, which will expand research capabilities for a molecule targeted photodynamic therapy in malignant cells. The proposed project and its funding will greatly improve applicant's abilities to establish a continuation and transfer of her research from USA to Slovakia, to introduce proposed methodologies in the Department of Biophysics, and to firmly anchor her long term career in Slovakia.",Monitoring of cell signaling pathways via interaction of fluorescently tagged proteins,FP7,31 May 2013,01 June 2010,75000.0 MOON,Bilkent University * Bilkent Üniversitesi,photonics,"Using wide-bandgap III-Nitrides, blue LEDs, blue lasers, and solar-blind detectors have been successfully demonstrated to date. III-N platform is, however, not limited only to these devices; it potentially offers new devices, applications, and commercial interest far beyond the current point. In this project, we propose to demonstrate new III-N optoelectronic devices that embody nano-scale quantum structures and/or incorporate multiple integrated micro-scale components to operate in the optical spectral range from the visible to the UV at Bilkent NanoTRC. One set of new devices includes III-N, high-speed, quantum electroabsorption modulators for fast data coding and ultra-short pulse generation across the UV-visible. These will enable high-speed optical interconnects and clock injection directly into Si CMOS detectors and chips (at >10 Gbps), e.g., in the blue, by eliminating the diffusion tail observed in the IR. They will also be useful for UV communication (space and underwater), time-resolved spectroscopy in biological and chemical agent detection (ozone depletion, security-threatening anthrax and SARS), and high-speed, high-capacity data storage on Blue DVD. Another set of devices includes III-N integrated optoelectronic circuits. For example, a GaN-based receiver may replace the photo-multiplier-tube (PMT) technology by reaching the PMT sensitivity and providing unprecedented speed. Upon returning from the USA to Turkey, this project will facilitate Dr. Demir to transfer the knowledge and experience he has acquired on quantum structures, integrated optoelectronic circuits, ultrafast optoelectronics characterization, microfabrication and process integration during his last 6 years of research work in collaboration with Intel Co. at Stanford University. With its new MOCVD system, NanoTRC provides a complete infrastructure for III-N epitaxial growth and nanofabrication. This project is expected to fertilize Dr. Demir's reintegration to the Center and EU.",Modern Optoelectronics On III-Nitrides,FP6,30 September 2007,01 October 2005,80000.0 MOQUAS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"MoQuaS aims at developing devices and protocols to read out and process quantum information using individual molecular spins embedded in electronic circuits. To this end, prototypical hybrid nano-devices addressing single molecular spins will be designed and reliable methods for their realization will be developed. Core of such nano-architectures are magnetic molecules, specifically functionalized to graft electrodes, and exploited as spin (qu)bits. MoQuaS will design and realize the necessary platform for the read out and the manipulation of the electron and nuclear states of single molecules. Besides electromigrated junctions, contact electrodes based on carbon allotropes, including carbon nanotubes and graphene nano-ribbons will be developed. These will allow for interfacing the specially designed magnetic molecule to the outside world with an unprecedented flexibility, beyond what is possible with metallic electrodes. The resulting hybrid device will function either as molecular spin transistors (three terminal device) or as molecular spin valves by combining carbon based channels with molecular spin filters. The ultimate ambitious goal of MoQuaS is the implementation of quantum gates that will be achieved by using additional strip lines close to our hybrid nano-devices to carry out the spin manipulation. On the way to achieving this goal, a range of challenges will be met by implementing experiments and theoretical descriptions that will ascertain the fundamental mechanisms underlying the functioning of quantum molecular devices. In particular, the key processes of the electron and nuclear spin state preparation, manipulation and read out, spin injection and relaxation will be individually investigated in order to understand the basic mechanisms and then combine the knowledge into prototypes that will set references for a new era in Spintronics in which Quantum information is encoded by Molecular processors.",Molecular Quantum Spintronics,FP7,30 September 2016,01 October 2013,2006000.0 MORDRED,Aalto University * Aalto-yliopisto,information and communications technology,"In this project we will develop multiscale modelling technology supported by comprehensive experimental characterization techniques to study the degradation and reliability of next generation Complimentary-Metal-Oxide-Semiconductor (CMOS) devices. Building upon fundamental analysis of the structure and electronic properties of relevant materials and interfaces at the quantum mechanical level, we will construct mesoscale models to account for defect generation and impact on CMOS transistor and circuit performance and yield. The models will provide detailed understanding of the common reliability issues and degradation routes, and will be verified by cutting edge experimental characterization. Strong links with industry insures that the project will make a step change in the process of next generation device modelling and design. The project will provide technologists, device engineers and designers in the nano CMOS industry with tools, reference databases and examples of how to produce next generation devices that are economical, efficient, and meet performance, reliability and degradation standards.",Modelling of the reliability and degradation of next generation nanoelectronic devices,FP7,03 July 2017,04 January 2011,3624853.0 MOREDITH,Technische Universiteit Delft * Delft University of Technology,health,"A network of research groups at the neighboring Delft University of Technology and the Erasmus University (Rotterdam) offers training for early stage researchers through a project on the development of (i) a group of effective and specific contrast agents for medical diagnostic techniques, including MRI (Magnetic Resonance Imaging), PET (Positron Emitting Tomography) and SPECT (Single Photon Emission Computed Tomography) and (ii) similar compounds that can be used for therapy. The specificity of both classes of compounds will be optimised by utilising molecular recognition for the accumulation of the diagnostic or therapeutic drugs concerned in the region of interest. A modular approach will be used in the design of the compounds. Consequently, an easy exchange of modules will allow optimal exploitation of them. Furthermore, this will stimulate the contacts among workers in the various disciplines and exchange of ideas. The consortium covers the development of targeting diagnostic and therapeutic drugs from the design to the (pre)-clinical stage.Five early stage researchers will be hosted for a period of three years. In addition, the hosting groups will offer the opportunity for more specific training via 6 shorter stays (6 months each). The training programmes will be complemented by a lecture course 'Metals in Medicine' that will be given by specialists of the research groups concerned every second year.This will ensure that the fellows will be trained in a broad range of disciplines (organic synthesis, coordination chemistry, nanoparticles, radiochemistry, nuclear medicine) and that they will meet a variety of techniques. This highly multidisciplinary training programme will deliver scientists with a broad knowledge base. Therefore, these scientists will be well-prepared for a research career in industry and academia.",Molecular Recognition for Diagnosis and Therapy,FP6,31 October 2008,01 November 2004,999534.0 MOSAIC,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"Innovative components and systems based on nano-engineered semiconductor, magnetic or insulating materials will be the driving force for the micro- and nano-electronics industry of the 21st century. For telecommunications systems, but also for data storage and Automation, Control and Security applications, alternative More than MOORE paths to systems are provided by nano-scale microwave spintronics components due to (i) their unique spin polarized transport properties that appear only at nanoscale dimensions (<100nm lateral, and 2-5 nm vertical), (ii) their unique (multifunctional) microwave properties including signal generation, processing and detection and (iii) their compatibility with CMOS technology. Going beyond previous fundamental research on spintronics devices, this project will target technological breakthroughs not only to generate, but also to process (mix, modulate, synchronise) and to detect microwave frequencies. Based on innovative spin transfer devices, four discrete systems will be developed that address bottlenecks of current technologies: A Wireless Telecommunications 1: Ultrawideband frequency synthesis provided by spintronics microwave components with novel circuit design on CMOS for realization of an adapted phase locked loop; B Wireless Telecommunications 2: Ultrafast frequency detection using frequency discriminating level detection; C Data storage: Novel dynamic readout schemes for detecting frequency shifts implemented for realization of high data rate read heads; D Automation control & security : Broad bandwidth, high slew rate proximity sensor based on frequency generation and modulation capabilities.","MicrOwave Spintronics as an AlternatIve Path to Components and Systems for Telecommunications, Storage and Security Applications",FP7,09 June 2018,01 January 2013,0.0 MOSEL,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),photonics,"Vertical cavity surface emitting lasers (VCSELs) have several particular advantages over the edge emitting lasers (EEL) for replacing them in optical communications applications, as the possibility of wafer-level testing during the fabrication process as well as facilitated optical coupling and overall module packaging. Nevertheless, several major improvements should be brought to the existing VCSELs before they become widely used in high speed optical datacom links. Among existing limitations, a limited power delivered by high speed (10 Gbit/s and up) transversely monomode VCSELs. This limitation is a key issue for the introduction of VCSELs in FTTx devices, especially in Passive Optical Networks where the power launched into the fiber must be rather high. Hence, mode size and polarization control are key issues in design of high performance VCSELs. Introducing elements of photonic crystal is an efficient way to increase the mode size while maintaining or even improving operating characteristics. In the present project, we aim to achieve an overall improvement of the VCSELs performances using micro and nanoscale patterning. The novel cavity configurations explored will allow: to increase the size (and thus the power) of the fundamental transverse mode of the VCSEL; to keep the laser transversely monomode at much larger current ranges; through the latter, to improve the modulation speed of the lasers; to control the polarisation of the emitted beam in temperature range and under modulation. Two general geometrical configurations, patterning of the mirrors and patterning of the cavity close to the active layer will be explored.The objective of the project is to demonstrate a configuration of the vertical cavity that would allow a 10-fold improvement in the monomode powers over the conventional VCSEL structures operating at 850, 1310 and 1550 nm. This improvement should be obtained while keeping appreciable modulation speed (10 Gbit/s) and a single polarisation.",Monomode Surface Emitting Lasers,FP6,31 May 2009,31 May 2006,2391345.0 MOST,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"Molecular Electronics and Molecular Magnetism are two rapidly emerging fields of Nanoscience, with a strong potential impact for the realization of new functions and devices helpful for information storage as well as quantum information. This project aims at the merging of the two fields by the realization of molecular junctions that involves magnetic molecules, thus opening the way to molecular spintronic devices. In order to tackle the challenge of controlled connection at the single molecule level, we will design a process of molecular self assembly on nanojunctions obtained in which bottom-up and top-down approaches will be merged. This will involve a direct and close collaboration between chemists and physicists and the creation of strongly multidisciplinary competences. Functionalised molecule having a well-characterized magnetic behaviour will be used, such as molecular magnets based on transition metals or lanthanides. It has been theoretically predicted that the magnetoresistance of a molecular junction based on a molecular magnet could lead to a direct measurement of spin tunnelling at the single spin level. The experimental confirmation of such a prediction would open the way to a control of single spin states and establishes the new field molecular spintronics. Such an achievement would have enormous scientific and technological consequences.",Molecular Spintronics,FP6,30 November 2008,01 December 2006,149103.0 MOTORBRAIN,AIlGreenVehicles,information and communications technology,The overall objective is to develop sustainable drive train topologies including control concepts for inherently safe electric vehicle power-train. The project focuses on significant steps ahead in terms of:,Nanoelectronics for Electric Vehicle Intelligent Failsafe Drive Train,FP7,03 January 2014,04 January 2011,0.0 MOTORS,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),health,"Intracellular transport plays a key role in many cellular processes. Cells rely on a well-regulated, two-way transport system that consists of molecular motors and cytoskeletal filaments for their correct functioning. In nerve cells, breakdown of transport is tightly linked to neurodegenerative diseases. Understanding what goes wrong with intracellular transport during disease requires knowledge of how motors work inside cells to transport cargo. While much effort has been devoted to understanding motor mediated intracellular transport, our knowledge of motor-cargo and motor-microtubule interactions in the cellular environment is still very rudimentary. The small size of motors, the complex architecture of their microtubule tracks, and the inherently dynamic nature of transport have made these interactions virtually inaccessible to observation in living cells until recently. With new advances in fluorescence microscopy, in particular with the development of ground-breaking methods that surpass the diffraction limit, we can finally begin to address this challenging problem. In this ambitious proposal we will study, at an unprecedented level of detail, the nanoscale organization and stoichiometry of motor proteins on their cargo and interactions of motor proteins with microtubules in living cells. We will achieve this goal by using a multidisciplinary approach that combines cutting-edge biophysical tools such as single particle tracking, quantitative single molecule counting and super-resolution nanoscopy with novel genetic manipulation and fluorescence labeling methods. Using these unique set of tools we will unravel the molecular mechanisms that regulate motors to achieve efficient transport. The results obtained in this proposal will provide, for the first time, a detailed picture of how motors function inside living cells, greatly enhancing our knowledge of a fundamental cell biological process and of its implications in disease.","On the move: Motor-cargo and motor-microtubule interactions studied with quantitative, high spatio-temporal resolution microscopy in vivo",FP7,31 August 2018,01 September 2013,1678441.0 MOWSES,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,Semiconductor industry rapidly approaches the performance limits of silicon-based CMOS technology. This proposal aims to pave the way,Nanoelectronics based on two-dimensional dichalcogenides,FP7,02 April 2019,03 January 2013,0.0 MPI-ANGIO,Bilkent University * Bilkent Üniversitesi,health,"Magnetic Particle Imaging (MPI) is a new imaging modality with the ideal image contrast for angiography that uses completely different hardware from X-ray, CT, or MRI. MPI is now at an exciting stage of development similar to where MRI was in the early 1980s. Currently, there are no commercially available MPI scanners. Only a handful of prototype small animal MPI scanners have been constructed worldwide in research environments. Yet, there is already great promise for diagnostic application of MPI for the three top mortality diseases in the world: cardiovascular disease (25% of all deaths), cancer (23%), and stroke (5%). MPI angiography shows great promise as a noninvasive, non-ionizing replacement for the millions of high-risk iodinated contrast studies performed annually. The contrast agent used in MPI, Super-Paramagnetic Iron Oxide (SPIO) nanoparticles, has been found to be extremely safe, even for chronic kidney disease (CKD) patients whose kidneys cannot safely excrete iodine contrast agents of X-ray and CT angiography. Indeed, SPIOs are now EU approved to treat anemia in CKD patients. With this proposal, Dr. Saritas will begin development of Turkey's first MPI laboratory, and transfer her MPI expertise acquired at University of California, Berkeley to the scientific community in Europe. MPI-ANGIO project proposes several innovations in MPI hardware, contrast agent and pulse sequences to improve MPI's spatial and temporal resolutions, now ~2 mm pixels and 7-minute scan time, to a much sharper 300-micron resolution at 2-4 frames/second.",Magnetic Particle Imaging for Safe Angiography,FP7,30 September 2017,01 October 2013,100000.0 MPIS-FET,Aston University,information and communications technology,"This project, entitled ‘Metal-Piezoelectric-Insulator-Semiconductor Field-Effect-Transistor’ (MPIS-FET), will fabricate a metal-piezoelectric-insulator-semiconductor field-effect-transistor device for pressure sensing, in order to perform high-sensitivity strain detection (gauge factor>100) under harsh conditions (high temperature>500oC). High-temperature pressure sensors are of extreme importance for automotive, aerospace, aircraft, power generation industry, and scientific instruments. The current pressure sensors suffer from various drawbacks such as poor thermal stability, low sensitivity, poor chemical inertness, high complexity in readout circuit, and high cost.",Metal-Piezoelectric-Insulator-Semiconductor Field-Effect-Transistor for high temperature pressure sensing applications,FP7,03 October 2016,03 November 2014,0.0 MRECB,Bar-Ilan University,health,"Cells carry out biochemical and physiological functions in the body by intricately controlling the position and activity of matter at the nanoscale. In contrast, our ability to exert equivalent spatiotemporal control over therapeutic molecules is extremely inadequate. That is the reason why although we have very effective therapeutics, their use is often limited by excess toxicity and adverse effects. We have recently described an autonomous, logic-guided DNA origami nanorobot, capable of transporting molecular payloads between selected points of origin and target, and demonstrated its selectivity and efficacy in inducing tumor cell apoptosis. Here, we propose to create nanorobots that can be programmed to exhibit collective behaviours. This will provide unprecedented, nearly absolute spatiotemporal control over many therapeutic molecules simultaneously. Using the molecular equivalents of computer programs, which we describe here, these nanorobots will be able to communicate with each other, coordinate timing of activity, form meta-structures, exhibit quorum-sensing capabilities and emulate logical operations using biological cues as bits. This proposal describes nanorobot design and control, and shows how the nanorobots can be modified to exhibit improved pharmacokinetic performance with negligible immunogenicity and toxicity. This technology could revolutionize therapeutic paradigms and procedures, along with other aspects of current medicine.",Molecular Robots Exhibiting Collective Behaviours,FP7,30 September 2018,01 October 2013,1496063.0 MRFLUIDS,University of Granada * Universidad de Granada,manufacturing,"A class of materials called smart materials is taking more and more importance due to thegrowing capabilities of computer control in our surroundings. These materials are usually compositestructures whose properties can be controlled by an external parameter; it can be temperature for shapememory alloys or electric fields for piezoelectric transducers. In all these cases we are interested incontrolling the properties of a material by some electronic device which senses environmental changesand adapts its response accordingly.Magneto-rheological fluids (MRF's) represent an exciting family of smart materials that possessthe unique ability to undergo rapid (within milliseconds) and nearly completely reversible changes intheir strength (yield stress changes from 0 to lOOkPa) upon application of an external magnetic field.MRF's typically consist of fine particles of a magnetically soft material dispersed in an organicmedium.Although a wide variety of applications of MRF's have been identified (semiactive shockabsorbers, dampers, computer-aided polishing of precision...) they have not yet enjoyed widespreadcommercialization (only two, American, companies produce such composites: Lord-Corporation andFerrofluidics). A major reason for this situation is that many MRF's do not satisfy the diverse andstringent requirements demanded in their applications: Ã.- the stability of the fluids againstsedimentation remains a central problem, and il- their tribo-rheological properperties are not wellunderstood.The main objective of this project is to develop a magneto-tribo-rheometer and characterize newadaptative materials based on field-responsive nanoparticles. We would synthesize magnetically hardhigh-permeability inverse spinel ferrites for MR applications using a modified sol-gel coprecipitationmethod in the presence of a magnetic field. Both magnetic and tribo-rheological properties would bestudied in the presence#'",TRIBO-RHEOLOGY OF NANOSIZED MR-FLUIDS,FP6,30 August 2006,31 August 2005,40000.0 MRHELIMAG,University of Cambridge,information and communications technology,"It is the aim of this research project to carry out systematic studies of spin-dependent transport in heavy rare earth (RE) metals based multilayered nanostructures. These nanoscale heterostructures made of layered rare earth metals would combine in variety of ways species bearing different magnetic character, such as ferromagnetic and antiferromagnetic order, as well as magnetic layers with non magnetic spacers. There exists a substantial gap in the literature regarding magnetoresistance (MR) studies on rare earth nanostructures, which would be of general interest for basic knowledge to fill in. This way, of particular interest will be to perform MR experiments for current perpendicular to plane configuration in vertically nanostructured RE-based systems, where the magnetic RE slabs show helical antiferromagnetic (AFM) order. For these structures, there exist recent investigations that clearly point to the breaking of the chiral symmetry at the interfaces. This chiral asymmetry in helical AFM is likely to lead to much striking effects in the magneto-transport phenomenology of such so far unexplored nanostructures that we now coin as the so-called anisotropic chiral magnetoresistance in analogy to the already proposed electrical magnetochiral anisotropy in chiral conductors. A second topic that will very much focus our attention is the study of magneto transport in multilayered nanostructures of rare earth metals that would combine ferromagnetic, helical AFM and non-magnetic layers. These studies will look to test recent theoretical predictions that forecast a significant enhancement for the overall performance of such nanostructures, which includes nanostructured slabs with helical magnetic order that bear a spin spiral density wave, for current-driven spin-torque transfer effect devices with nanotechnology applications in the field of microwave oscillator systems for high-frequency communication technology.",Spin-Transport in inhomogeneous Ferromagnets,FP7,03 July 2015,04 January 2010,45000.0 MSOT,German Research Center for Environmental Health * Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH,health,"With re-defined challenges in post-genome biology and medicine related to understanding the regulation and function of genes, proteins and multi-factorial disease, the development of accelerated and quantitative in-vivo observation of functional -omics at different system levels becomes a vital target. This proposal offers to develop therefore a next-generation biomedical imaging platform, designed to radically impact biomedical and drug discovery applications. The imaging strategy aims at resolving powerful optical reporters (fluorescent proteins, nanoparticles, optical probes) with 10-100 micron resolution and femptomole sensitivity through several millimeters to centimeters of tissue. This performance brings unprecedented ability to non-invasively visualize biological and molecular processes in-vivo in intact organisms over time. To achieve these goals, the proposal considers first the development of multi-spectral opto-acoustic tomography (MSOT) as a high performance method for revolutionizing biomedical imaging. Then, the proposal offers to develop powerful application areas in visualizing functional –omics, disease growth and drug effectiveness. The advancements offered herein can become a highly preferred biomedical imaging modality while offering ground-breaking imaging performance, safe non-ionizing radiation, an easy to disseminate platform, and unparalleled flexibility in capitalizing on powerful optical contrast using molecular reporters.",Next Generation in-vivo imaging platform for post-genome biology and medicine,FP7,30 June 2014,01 March 2009,1999992.0 MUAPPEN,University of Nottingham,energy,"Energy crisis and environmental pollution have been suggested to be two serious problems to world countries. The efficient energy generation and use of clean energy are the effective pathways for solving these problems. This project promotes a cutting-edge research collaboration on the development of the late-model multi-junction nano-materials for energy applications in relation with solar energy driven production of hydrogen from water and rechargeable battery for renewable energy storage. Using a modified electrochemical atomic layer deposition method, multi-junction materials with large specific surface areas or complex shapes can be produced with a formation mechanism of atom-by-atom growth. Based on this, the narrow-band-gap semiconductors are conformally deposited onto TiO2 nanotube arrays (NTs) to form a coaxial heterogeneous structure with atomic-level control. Such structure can greatly improve the separation efficiency of photo-induced electrons and holes, resulting in a highly active photocurrent generation. On the other hand, both sulphur and carbon atomic layers are deposited alternately on the TiO2 NT walls in the atom-by-atom contact form. The resultant sulphur-carbon/TiO2 NTs multi-junction positive electrodes demonstrate properties useful for resolving these bottleneck problems that exist in the current Li-S battery. Furthermore, the relationships among the optimizing designs (including micro-geometrical structures, compositional control, and atomic-level interface properties), the charge transfer mechanism, and electrochemical performance are studied. On the basis of these results, the high-performance multi-junction photocatalysts and rechargeable Li-S battery are carried out for hydrogen generation and energy storage application. The proposed research will enrich the synthesized methods for multi-junction nano-materials, and be extremely useful to advance the technological quality of existing energy generation and energy storage industries.",Multi-junction nano-materials with coated highly ordered structure and their Application in energy generation and Energy storage,FP7,,,309235.0 MUCOSINT,Gazi University * Gazi Üniversitesi,health,"Multifunctional nanoparticles hold great promise in targeted therapy as well as other biotechnological fields such as biomolecule sensing and cell separation. The potential of these particles to controllably deliver and accumulate therapeutic and diagnostic agents to target sites in the body make them especially useful platforms for the research in various disease types. Ideal particles for these applications should be easy to synthesize, have minimal size variation and hold efficient functionalities. Combining all these properties in the nanoscale level, however, is a formidable challenge. This project proposes a new class of non-spherical nanoparticles called Multifunctional Composite Silica Nanotubes (MuCoSiNT) for targeted therapeutic delivery applications. MuCoSiNTs will be fabricated by a facile synthesis method that allows absolute control over particle dimensions and functionalities. Moreover, they comprise large inner voids that will be filled with a composite gel matrix for the targeted delivery of imaging and therapeutic agents at high payload capacities. The in vitro cytotoxicities and antitumor activities of these particles will be determined by examining their effect on cellular viabilities and growth inhibition profiles. Finally, MuCoSiNT internalization into the cells and consequent morphological changes will be confirmed using microscopic techniques.",Multifunctional Composite Silica Nanotubes for Targeted Delivery,FP7,31 December 2012,01 January 2010,75000.0 MUFLY,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),transport,"Despite the many impressive examples of human inventiveness, our technological solutions often pale in comparison with the elegance, effectiveness, power efficiency and supreme functionality with which nature has solved so many problems. This is particularly true for the flight of birds: No comparable technical solution of a small, autonomously flying vehicle has yet been demonstrated, despite the many potential applications. This project proposes, therefore, the development and implementation of the first fully autonomous micro helicopter comparable in size and weight to a small bird. The key challenges of the project include innovative concepts for power sources, sensors, cameras, navigation and helicopter design and their integration into a very compact system. The envisaged fully autonomous micro-helicopter will weigh less than 30g and measure only 10cm in diameter. The project shall develop and demonstrate innovative approaches and technologies in (1) system level design and optimization of autonomous micro aerial vehicles, (2) multifunctional use of components (integration of camera and distance sensor, batteries doubling as structural elements, or a propeller combined with gyroscopic stabilization), (3) design of ¿smart¿ miniature inertial sensor and omnidirectional vision sensors with polar pixel arrangement, (4) miniaturized fuel-cells, (5) miniaturized piezoelectric actuators with enhanced power to weight ratios, and (6) control and navigation concepts that can cope with limited sensor and processing performance. The resulting micro-helicopter will represent the fist demonstration of a fully autonomous indoor flying robot of its size and its successful realization will be a landmark achievement in integrated micro/nano technology and micro aerial vehicles.",Fully Autonomous Micro Helicopter,FP6,30 September 2009,30 June 2006,2699934.9 MULTI-PGNAS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Transporting, organizing, attaching, guiding, releasing entities of various dimensions over different scales remain central to the development of high throughput biological devices able to conduct millions of tests in a short period of time. The proposed project intends to develop a new generation of substrates for cell manipulation based on photothermal processes. Specifically, it focuses on realizing standard and new functions related to tissue engineering and cell transportation by designing a single type of platform. This project aims to implement photothermal gold nanoparticle arrays (PGNAs) to physically manipulate various types of entities, like living cells. Each gold nanodot will play the role of an adhesive spot exposing the RGD peptide, which are separated by nonadhesive regions functionalized with poly(ethylene glycol) (PEG), so that cell-binding sites will exclusively interface the nanoparticle. By irradiating well-defined areas of the PGNAs with a focused laser beam, the fellow hopes to take advantage of the local heating generated by the nanoparticles to prevent cell attachment in these hot areas. This way, it is possible to study and integrate multiple functions in order to deliver one unique dynamic platform able to precisely control both cell adhesion (releasing, patterning, guiding) and cell transportation (via optofluidics) at the PGNA interface. The 'Multi-PGNAs' project may permit to integrate the same nanotechnology for the development of modern applications, while providing innovative methodologies for designing new experiments in cell biology and nanophysics.",Multifunctional Photothermal Gold Nanoarrays for Cellular Manipulation,FP7,14 July 2010,15 July 2008,162096.0 MULTIBIOPHOT,Humboldt University of Berlin * Humboldt-Universität zu Berlin,health,"Proposal summary Biophotonics is an emerging interdisciplinary field. Modern laser spectroscopic methods in combination with microscopy open up exciting new ways to study biological objects. For biological applications, multi-photon or non-linear spectroscopy can offer several advantages over one-photon excitation. The aim of this project is to explore novel spectroscopic strategies based on multi-photon excitation. In order to overcome lowsignal problems related to multi-photon spectroscopy, we will exploit plasmonics and perform multi-photon spectroscopy in the enhanced local optical fields of gold- and silver nanostructures. I propose a combination of three different plasmonics-enhanced two-photon spectroscopic methods for multimodal two-photon sensing and imaging. This combination can provide information on morphological structures and function of biological systems along with chemical information about molecular composition, structure, and interactions. A key aspect of this new concept will be the implementation of spectroscopically multifunctional nanosensors with plasmonic nanoparticles as basic building blocks. Following multi-photon excitation, these sensors deliver information on their environment inferred from a set of multiple surface-enhanced spectroscopic signatures. The proposed research will generate fundamental knowledge about multi-photon driven processes in enhanced local optical fields and about multi-photon interaction of light and biological matter. This might open up entirely new directions to advance nanobiophotonics. In particular, the outcome of the research will stimulate the new field of two-photon sensing and imaging, which has the capability to advance our understanding of biological systems and processes. The project is expected to have broad impact and contribute to the development of multi-photon optical sensing and multi-photon excited photophysics and photochemistry with applications in physics, chemistry, energy technology, biotechnology and medicine.",Multiphoton processes using plasmonics towards advanced nanobiophotonics,FP7,31 December 2015,01 January 2011,1394679.0 MULTICERAL,University of Aveiro * Universidade de Aveiro,manufacturing,"MULTICERALis a joint effort of eight European research institutions/universities from six countries (UK, Germany, France, Portugal, Slovenia, Lithuania) aimed at the development, detailed characterization, and evaluation of novel multifunctional thin-film materials based on ferroelectrics [Pb(Zr,Ti)O3, BaTiO3, SrBi2Ta2O9], magnetics and shape memory alloys (SMA) (Ni2MnGa, BiFeO3), and relaxors [PbMg1/3Nb2/3O3, Ba(Ti,Zr)O3] assembled in complex geometries. These include planar films and multilayers, hybrid sol-gel composites, and vertically assembled tube and nanowire arrays. We expect that such geometries will greatly enhance the cross-coupling between magnetic, electric, and elastic T-dependent properties and give rise to unrivaled multifunctionalities unavailable so far. For example, the microactuator based on ferromagnetic shape memory alloy/piezoelectric bilayer will respond to electric/magnetic/stress fields while exhibiting two-way shape memory effect. Another example is magnetically tuned capacitor with giant magnetodielectric coupling based on magnetic/piezoelectric multilayers. At least two prototype devices based on the high cross-coupling effects will be fabricated/tested in this project proving the proposed concepts. The variety of the available deposition techniques combined with using advanced characterization tools will ensure that the desired thin film geometries will be assembled with minimum cross-contamination, non-stoichiometry and defect formation. These efforts will be supported by the extensive modeling activities aimed at the elucidation of the nature of magnetoelectroelastic coupling in thin films, calculation of the effect of curved geometries on cross-coupling effects, and influence of disorder and long-range interactions on the properties of multilayers and magnetic/ferroelectric domain patterns. Finite element calculations will be performed once the physical mechanism of the relevant coupling effect is clarified.",Multifunctional ceramic layers with high electromagnetoelastic coupling in complex geometries,FP6,30 April 2010,01 November 2006,1550000.0 MULTICHIP,Universiteit Twente * Twente University,health,"MULTICHIP production of a multiplexed microarrays provides an exciting business opportunity. MULTICHIP offers unique advantages in areas of large societal importance, such as public health, and environmental safety. Multiplexed microarrays, i.e. arrays with a high number of different biomolecules, are attractive for rapid screening such as early detection of cancer and farm animal diseases, and multitoxin screening of ecosystems. Conventional array production methods lack in quality or multiplexing abilities. Moreover, technologies like dip-pen nanolithography require intensive training of personnel, which seriously limits the potential user groups. MULTICHIP enables easy, cheap production of multiplexed arrays by stamping biomolecules. Extensive re-use ( up to 75 times) of stamps is possible and MULTICHIP can be used to stamp a wide range (10 kDa -1 MDa) of biomolecules. MULTICHIP can also stamp on soft surfaces, which is of particular importance for tissue engineering, and reconstructive medicine. These factors greatly enhance application potential. Stamping techniques have been suggested earlier, but as hydrogels are used for storage of biomolecules in the stamp reservoirs, lifetime, re-use capability (maximum 4-5 times), and range of biomolecules (maximum 150 kDa) that can be stamped are extremely limited. Stamping is only feasible on hard surfaces. In MULTICHIP innovative, robust macroporous polymeric networks are used for biomolecules storage, creating a breakthrough in multiplexed microarray production. In this project, a business case will be developed for MULTICHIP, covering different markets, and routes for market introduction. Results of market analysis (market size and segmentation, expected sales and financing needs) will be combined with science-based technology comparison into comprehensive documentation for discussion with potential industry partners. Several industries already have expressed their interest in MULTICHIP.",Explore the potentialities of multi-print chips for diagnostic research,FP7,30 September 2013,01 April 2012,150000.0 MULTIFERRO-SOL-GEL,University of Aveiro * Universidade de Aveiro,manufacturing,"Ferroelectric ferro/ferri-magnetic multiferroic materials are interesting materials not only because they have the properties of their parent materials, but especially because interaction be-tween those polarizations can take place (e.g. magnetoelectric effect). Up to now, those materials are synthesized only by ultra high vacuum (UHV) deposition tech-niques (i.e. pulsed laser deposition PLD) In this work we are going to use non-aqueous sol-gel approaches to synthesize multiferroic materials by following parallel concepts: 1) Synthesis of core-shell particles by the benzyl alcohol route. 2) Synthesis of thin film heterostructures by new atomic layer deposition (ALD) assisted by non-aqueous sol-gel reactions. 3) Combining the benzyl alcohol route (formation of ferrimagnetic particles) and the ALD (coating of the particle with ferro/piezo-electric material) deposition in order to produce multiferroelectric heterostructures. Once synthesized, these materials will be characterized and the ferroelectric, ferromagnetic properties and the magnetoelectric effect intensively studied.",Multiferroic nanostructures: a non-aqueous sol-gel approach.,FP6,30 November 2008,01 December 2006,138247.0 MULTIFLEXIOXIDES,Institute for the Development of New Technologies * Instituto Desenvolvimento De Novas Tecnologias (UNINOVA),transport,"Added value features associated with high performance transparent displays have the potential to catapult the electronics industry into a new era of growth.Features such as transparency and flexability promise the emergence of a plethora of new application spaces in sectors ranging from the automotive to computer based industries,where applications will be based on the discreetness of the devices as much as the electronic functionality. The flexible nature of devices will have impact on both the device application space and also on the manufacturing of flexible electronics.The use of flexible plastic substrates will facilitate a migration away from fab based batch processing to large area,roll to roll manufacturing technology which is perceived as offering a significant advantage in terms of reduced cost with increased throughput due to fewer manufacturing steps and as such will have tremendous industrial impact.There are significant challenges to overcome in order to enable the vision of low cost,environmentally friendly manufacturing and to achieve high performance electronic devices with the required mechanical and optical attributes.The technology barriers to be overcome include: the development of radically new materials which can offer the electronic,mechanical and optical properties required:the development of novel deposition techniques which enable low temperature,large area processing on flexible substrates: the development of non-fab based low temperature patterning techniques on flexible substrates.The MULTIFLEXOXIDES project aims to address these materials and processing challenges so as to retain Europe's status at the forefront of flexible electronics,developing so radically new ceramic thin films,(amorphous or nanostructured) which can be utilised as flexible and transparent conducting, semiconducting and insulating device components.Their inorganic nature should result in environmentally stable and long lifetime devices and systems.",MULTICOMPONENT OXIDES FOR FLEXIBLE AND TRANSPARENT ELECTRONICS,FP6,28 February 2010,01 September 2006,1800000.0 MULTIFLOW,Loughborough University,health,"Understanding and controlling of interfacial phenomena in multiphase fluid dynamics remains one of the main challenges at the crossroad of Mathematics, Physics, Chemistry and Engineering. Examples include film flows, spreading and dewetting of (complex) liquids including suspensions, polymer solutions, liquid crystals, colloids and biofluids. Such systems are central for technological advances in the chemical, pharmaceutical, environmental and food industries and are crucial for the development of Microfluidics and Nanostructuring. The level of detail required by multi-scale flows with interfacial phenomena renders full-scale analyses practically impossible. In fact, such approaches often fail to describe even the results of simple experiments. MULTIFLOW will develop low-dimensional models capable of describing complex interfacial flows coupling different time and length scales. Based on the nature of the dominant mechanism, the scientific program will examine three generic classes: from nano- to macroscale, these are dominated by surface forces, reaction-diffusion, and advection. They are also affected by phase transitions, capillarity, chemical reactions, complex rheology and self-structuring. The strength of the network is its integration of all scientific disciplines, technical skills and expertise necessary to support the multi-scale nature of the envisaged research topics. By fostering the mobility and interdisciplinarity of a strong group of early-stage researchers through a set of well-defined objectives and effective networking between different institutions, disciplines and industries, the ultimate goals of this network are: (i) to create a multi-disciplinary, highly innovative and intersectorial training pool in the field of multi-scale interfacial fluid dynamics; (ii) to generate new tools and techniques for the theoretical-numerical-experimental investigation of such flows, which will be made available to the wider European Community.",MULTI-SCALE COMPLEX FLUID FLOWS and INTERFACIAL PHENOMENA,FP7,31 December 2012,01 January 2009,6205912.0 MULTIFUN,Atos Spain SA,health,"The aim of the MultiFun consortium is to develop and validate a novel and minimally-invasive nanotechnology system to improve cancer diagnosis and treatment. MultiFun nanotechnology is based on multifunctionalised magnetic nanoparticles to selectively target and eliminate breast and pancreatic cancer (stem) cells. The improved magnetic features of the MultiFun magnetic nanoparticles will lead to potential medical applications such as contrast agents and magnetic heating inductors. Moreover, magnetic nanoparticles can be functionalised with ligands to increase their affinity towards cancer cells in order to facilitate diagnosis of tumours by MRI. Targeting peptides and antibodies will be employed, including antibodies against cancer stem cells leading to early cancer detection by MRI means. The same nanoparticles will be used simultaneously as functional nanocarriers and heating inductors in order to provide a combined therapeutic modality. The synergistic effects of drugs, peptides, small RNAs and heat will be evaluated to determine the effectiveness of different therapeutic combinations. Interestingly, the use of ligands will favour the specific application of the therapeutic modalities to cancer (stem) cells, increasing the effectiveness and reducing side effects. Thus, MultiFun multimodal therapeutic approach is designed to efficiently remove cancer cells, including cancer stem cells, from the tumour site. The toxicity of functionalised magnetic nanoparticles will be assessed in vitro and in vivo to warrant a safe use and shed some light on the risks. The distribution and activity evaluation of functionalised nanoparticles will be performed in human breast and pancreatic cancer xenograft models. The use of novel magnetic nanoparticles for biomedical applications provides opportunities for new instrumentation: 1) detection and quantification of magnetic nanoparticles in blood, urine and tissues, and 2) magnetic heating induction for raising cell temperature.",Multifunctional Nanotechnology for selective detection and Treatment of cancer,FP7,12 June 2015,13 June 2011,9799994.0 MULTIFUNCTNANOPOLYM,Consejo Superior De Investigaciones Científicas (CSIC),health,"Nowadays, one of the main scientific challenges is the fabrication of nanostructured materials (polymer nanofibres and nanotubes) in demand for a broad range of applications. Electrospinning has been shown to be an effective method for the production of polymer fibres with diameters in the range from several micrometers down to tens of nanometers. It has been found that the fibre diameter can be controlled within a broad range by proper selection of the processing parameters. For selected applications it is desirable to control not only the fibre diameter, but also the internal morphology. Nanostructured fibres as for example porous fibres are of interest for a broad range of applications in areas such as sensor or filter technologies and the preparation of functional nanotubes by fibre templates. Tubes with such dimensions may be used to store or transport gases or fluids, for fuel cells, near field optics, nano-electronics and combinational chemistry, for applications in the area of catalysis, drug release or even encapsulation. Composite materials trying to mimic the exceptional properties of many biomaterials, and particularly polymer nanocomposites are materials with great scientific and technological challenges related to their promising nanostructure-property correlations. The development of carbon-nanotube-reinforced polymer composites not only offers unique opportunities to improve the physical and mechanical properties of a given matrix but also allows the evaluation of the intrinsic properties of the reinforcing nanoscale phase. The key technical challenges which remain for such carbon-nanotube-reinforced polymers are the achievement of a homogeneous dispersion, good interfacial bonding and a controlled degree of alignment. It is also apparent from these studies that an ability to predict nanocomposite properties for a given filler type and loading fraction remains challenging.",Multifuctional Polymeric Materials though Nanostructuring,FP6,24 February 2006,25 February 2005,40000.0 MULTIGRAPHCHEM,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,information and communications technology,"The aim of MultiGRAPHCHEM is to undertake an extensive scientific program on the synthesis and characterization of a broad range of Multifunctional Graphene Systems. The multifunctionality will arise from the combination of -and the interplay between- the outstanding Graphene properties with those arising from the functionalization, which will be magnetic, optical, electrochemical and/or catalytic.",Multifunctional Graphene by means of a Chemical Approach,FP7,09 February 2017,09 March 2015,0.0 MULTIMATDESIGN,Centre for Materials and Coastal Research * Helmholtz-Zentrum Geesthacht – Zentrum für Material- und Küstenforschung GmbH,health,"Many technical processes involve permeation of molecules of various sizes through nanostructured materials. The characteristics of such permeation phenomena is governed by the structure and dynamics at the nanoscale level of the relevant materials. Typical applications are separation of fluid and gaseous mixtures, packaging and drug release. These materials are multifunctional, because they must combine the required permeability characteristics with suitable other properties such as mechanical stability or biocompatability. The main objective of MULTIMATDESIGN is to make decisive contributions to a breakthrough towards the knowledge-based design of the above materials. This objective will be accomplished by the extensive application of computer aided molecular design (CAMD) tools leading to the acquisition of new knowledge. CAMD is a very attractive approach allowing the detailed investigation of structure and dynamics on the length and time scales most important for the transport processes of interest. The potential for radical long-term innovation in related European industries by extensive use of CAMD will be demonstrated by combining (1) further methodological developments, (2) application of CAMD to find breakthrough solutions of economically important permeability related problems and (3) experimental tests of computer designed materials. This will considerably improve the competitiveness of European industry in this field. Among the participants are leading European groups in the field of development and application of CAMD tools for the design of the needed breakthrough in nano-structured multifunctional materials, as well as excellent groups in the area of experimental characterisation and actual preparation of these materials.",Computer aided molecular design of multifunctional materials with controlled permeability properties,FP6,29 February 2008,01 March 2005,2100000.0 MULTIMATE,Linköping University * Linköpings Universitet,health,"Nanoscale engineering is a fascinating research field spawning extraordinary materials which revolutionize microelectronics, medicine,energy production, etc. Still, there is a need for new materials and synthesis methods to offer unprecedented properties for use in future applications. In this research project, I will conduct fundamental science investigations focused towards the development of novel materials with tailor-made properties, achieved by precise control of the materials structure and compostition. The objectives are to: 1) Perform novel synthesis of graphene. 2) Explore nanoscale engineering of 'graphene-based' materials, based on more than one atomic element. 3) Tailor uniquely combined metallic/ceramic/magnetic materials properties in so called MAX phases. 4) Provide proof of concept for thin film architectures in advanced applications that require specific mechanical, tribological, electronic, and magnetic properties. This initative involves advanced materials design by a new and unique synthesis method based on cathodic arc. Research breakthroughs are envisioned: Functionalized graphene-based and fullerene-like compounds are expected to have a major impact on tribology and electronic applications. The MAX phases are expected to be a new candidate for applications within low friction contacts, electronics, as well as spintronics. In particular, single crystal devices are predicted through tuning of tunnel magnetoresistance (TMR) and anisotropic conductivity (from insulating to n-and p-type). I can lead this innovative and interdisciplinary project, with a unique background combining relevant research areas: arc process development, plasma processing, materials synthesis and engineering, characterization, along with theory and modelling.",A Research Platform Addressing Outstanding Research Challenges for Nanoscale Design and Engineering of Multifunctional Material,FP7,31 August 2015,01 September 2010,1484700.0 MULTIMOF,Technische Universiteit Delft * Delft University of Technology,environment,"The overall aim of this project is to engineer new mono and multifunctional nanostructured solids to be used as catalyst for multi-step, one-pot reactions. The key objectives are: 1. Create stable nano-structured super basic catalysts based on Metal Organic Frameworks (MOFs) by using synthetic and/or post-synthetic approaches. 2. Create nano-structured solids containing covalently bonded sulphonic groups by using synthetic and/or post synthetic methods. 3. Create acid MOFs with metal nanoparticles encapsulated in the MOF cavities (acid-metallic catalyst). 4. Produce acid-base MOFs by using synthetic and/or post synthetic approaches. The main motivations for the exploration and development of efficient catalysts are to conserve energy, to produce fine chemicals and to develop environmentally friendly and safe technologies. Despite major improvements over the past few decades, many existing commercial catalysts are still plagued by low efficiency, high cost, and/or production of large quantities of hazardous wastes. Furthermore, many of them have been designed to catalyze a single reaction in multi-step reactions or to produce multiple products, in contrast to industry’s needs for efficient multi-step, one-pot catalytic processes. The tailoring of multifunctional catalysts is a big challenge for the research community and for the society in general, since proper catalysts may reduce the economical and environmental costs of crucial catalytic process. Multifunctionality in heterogeneous catalysis has been scarcely studied, with respect to multifunctional solids, the heterogeneous catalysis toolbox is still empty. In this sense MOFs are called to play an important role in the near future due to their wide chemical versatility and modifiability. The emphasis and final target of this proposal is to design and to apply MOFs as bi-functional catalysts. The main part of the proposed project, will be carried out at the Delft University of Technology, abbreviated as TU",Preparation of Multi-Functional Metal Organic Frameworks catalysts,FP7,02 May 2014,03 January 2010,161748.8 MULTIMOF,University of Liverpool,health,"The project MultiMOF (Multifunctional Metal-Organic Frameworks) is a natural step beyond the work developed by the applicant during his PhD thesis in Molecular Magnetism. It intends to undertake an extensive scientific program on the design and physical characterization of a broad range of multifunctional Metal-Organic Frameworks (MOFs). Mutifunctionality will arise from the combination of their intrinsic properties such as lightness, porosity, flexibility or biocompatibility with magnetism or chirality and the interplay between them. MOFs can be defined as nanoporous crystalline compounds consisting of metal ions or clusters coordinated to multidentate organic ligands to form one-, two-, or three-dimensional structures. Resulting from the introduction of permanent porosity, these molecule-based materials have attracted important attention in the last decade because of their promising application in gas storage, separation, ion exchange, catalysis or drug delivery. Taking advantage of expertise of the University of Liverpool materials chemistry group in the synthesis and characterization of MOFs, we intend to introduce electronically active transition metal (TM) extended units and optically active organic linkers in these materials in order to combine magnetic or optical properties with those resulting from their open structure. This approach will result in the design of a whole set of magnetic MOFs including additional functionalities, which could be of remarkable importance for the future development of porous low-density magnetic materials, switchable magnets, chiral magnets, magnetic sensors or higher level multifunctional materials. In this way, the researcher will embark on a multidisciplinary work plan, learning new concepts in Coordination Chemistry and Crystal Engineering, essential for the design and isolation of these open frameworks, and Solid-State Physics, employed in the study and tuning of physical properties exhibited by these materials.",Multifunctional Metal-Organic Frameworks,FP7,31 August 2012,01 September 2010,173240.0 MULTIPLAT,Vienna University of Technology * Technische Universität Wien,health,"The goal of the MultiPlat project is to develop biomimetic proton conductive membranes with nanometer thickness (nanomembranes) through convergence of a number of fields. The primary application of this multipurpose nanotechnological platform is the next generation of fuel cells where it will replace the prevailing evolutionary modifications of the state of the art solutions. Secondary applications cover diverse fields, including photonics, sensorics, biointerfaces, medicine and others. The natural proton conductive nanomembranes are the most ubiquitous building element in biology. The core concept of the project is to postulate, introduce and fabricate a novel composite nanomembrane and to functionalize them through the integration of proton conducting nanochannels in a manner analogous to that in biological cells. At the same time the nanomembranes will be strengthened through the introduction of inorganic part. This functionalisation itself is a complex and largely unsolved issue. In this way the nanomembranes will merge artificial and biological properties. We intend to use convergence of diverse fields including physics, chemistry, biomimetics, and nanotechnology. The focus will be primarily on the use of various nanotechnology methods for nanomembrane fabrication, their functionalisation through lamination, surface patterning, inclusion of fillers and structural modification through the engineering of built-in nanochannels. The research should result in functional models and a breadboard model. The industrial partners will ensure the application of the results. The objectives of the project fully satisfy the call NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info, cogni). The expected impacts include breakthroughs in knowledge in the converging fields, important practical applications and industrial innovations, with major significance for clean energy production, environmental protection and welfare improvement.",Biomimetic Ultrathin Structures as a Multipurpose Platform for Nanotechnology-Based Products,FP7,30 November 2012,01 December 2009,2598329.0 MULTIPOC,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"The main objective is the development of highly multiplexed affinity proteomics tools for point of care diagnostics. Enabled by the world's largest resource of antibodies to human protein targets generated within the framework of the Human Protein Atlas program, the aim of this application is to develop new concepts in translational medical research to allow dramatic improvement in performance and accessibility of point of care tests in both high and low resource clinical settings in infectious diseases, autoimmune conditions and several cancers. To achieve the goal, developments will be made in 1) detection principles and sample preparation, 2) rapid and low cost protein microarrays assays and 3) novel amplification strategies. Strategies will be developed to for the first time enable highly multiplexed sandwich detection across the analytical range of the plasma proteome. Four different novel microarray formats amenable for point of care are presented that each will allow dramatically improved multiplexity and high performance. Different types of new multifunctional silica/gold nanoparticles exhibiting combinations of magnetic, fluorescent, electro-active, enzymatic and optical qualities that will allow deterministic actuation and multimodal detection options will be synthesized and applied for exquisite sensitivity and rapid detection. Following the technology development, developed assay systems will be implemented for full plasma proteome analysis and in the three clinical areas: infectious diseases, autoimmune conditions and cancers. Collaborations with clinical researchers in all the relevant fields have already been established. In theses clinical fields, a body of previous research efforts has shown that highly multiplexed plasma analysis may dramatically improve diagnostic accuracy, and it is here that the novel comprehensive point of care systems presented in this proposal may conceivably create the largest impact for patients and health care systems.",Highly Multiplexed Affinity Proteomics for Point of Care Diagnostics,FP7,31 March 2019,01 April 2014,2000000.0 MULTIPOL,University of Applied Sciences Western Switzerland * Haute École Spécialisée de Suisse Occidentale,energy,"The increasing need of organic polymers for electronic applications is becoming critical since this market is growing rapidly and the current materials being limited in terms of multifunctionality, price and properties. The MULTIPOL project will propose the development of radically innovative organic materials, based on the SOLID technology recently discovered by HE ARC. It was shown, that the polymer parylene can be deposited on a liquid substrate in a way that the liquid shapes of the overgrowing solid layer. The resulting configuration is chemically stable and is the base of an huge variety of new micro-nano systems. The partners will concentrate their efforts on electronic applications, such as electronic papers, smart magneto-polymeric sensors and actuators, and solar cells. For this purpose. MULTIPOL project aims at ?contaminating? the growing parylene layer in a controlled manner. Therefore, the objective of the projects will be achieved through the following steps: First of all, modelling and tools will be used to select the most promising liquids that should modify the properties of encapsulating parylene thin film. It is planned to prepare specific polymers, to use nanotubes/magnetic nanoparticles to add functionalities to the materials. Fast screening tests will be carried out. After the selection, the enabling step consists in the understanding of the reactions at the substrate-liquid and liquid-parylene interfaces. This will be achieved through modelling. In parallel, the CVD technology used for parylene deposition will be optimized and adapted to the final products requirements. Scenarios as direct gas phase or plasma enhanced impact on the growing parylene layer should allow to further ?tailor? the properties of the modified parylene layer and / or foster reaction to obtain the modified parylene layers. The last step is dedicated to the assessment of the multifunctionality and the properties for the end-users applications.","Multifunctional polymer materials and systems with tailored mechanical, electrical and optical properties",FP6,31 December 2009,01 January 2007,2199404.0 MULTIPRO,Research Center Plast-optica * Centro Ricerche Plast-optica SpA,transport,"The aim of the project is to develop new multifunctional material for opto-electronic devices based on solid state lighting sources, addressed to several applications and contemporarily, an integrated reactive packaging technology suitable for the material developed and cost effective for the application addressed. The nanostructured composite organic inorganic material developed will consist on a solid matrix (organic acrylate, or sol-gel hybrid organic inorganic) able to embed different kind of nanoparticles (imetal, metal oxide, semiconductor quantum dots) that will confer to the matrix functionalities depending on their own nature and size. In particular, the functionalities required are: high refractive index, wavelength conversion, high transmittance, thermal and electrical conductive, and barrier properties. MULTIPRO respond to the concept of the tailor to made, which means that the functionalities above described respond to specific needs of the application addressed which are: lighting device for automotive general illumination. Molecular modelling will be the enabling technology to tailor the material in terms of components necessary for the properties desired. The modelling will cover all aspects of the approach developed in the project; indeed it will be integrated in the pure components preparation, nanoparticles compatibilisation and reactive deposition process. The approach used in the project represents a breakthrough in multifunctional electronic packaging because foresees a complete integration between material preparation, processing and assembling of the final device. The consortium consist of 9 partners from 3 different EC states and 1 associate state: 4 industrial partners (3 SMEs and 1 industry), 1 industrial research centre, 1 non-profit research institute, and 3 universities. In particular the project will considerably contribute to strengthen ERA bringing together researchers from east Europe and Mediterranean country with EC states.","Design of 'tailor to made' MULTIfunctional organic materials by molecular modelling of structure property relationship, experimentation and PROcessing",FP6,31 October 2009,01 November 2006,1350000.0 MULTIQUANTUM,University of Bern * Universität Bern,health,"Multi-photon intravital microscopy (MP-IVM) is a powerful imaging technique which allows following cellular migration and interactions on a single cell level deep inside solid tissue of alive, anesthetized mice. A prominent example is the recent description of lymphocyte migration inside peripheral lymph nodes (PLN) during immune surveillance and responses to Antigen. Nevertheless, resolution of subcellular structures and molecular complexes is hampered by reduced brightness and rapid photobleaching of commonly used molecular fluorophores. Quantum dots (QD) are small fluorescent nanocrystals with superior optical properties compared to molecular fluorophores, such as resistance to photobleaching, large absorption spectra and narrow emission spectra, which can be controlled by crystal size. QD are intrinsically hydrophobic and need to be coated with specific peptides or other watersoluble substances for bioimaging. Here, we propose to use MP-IVM to observe interstitial migration and cellular interactions of lymphocytes labeled with commercially available QD for detection of surface molecule distribution. We furthermore propose to develop own application-specific QD coated with appropriate surface markers for internalization and labeling of intracellular signaling complexes. We expect this proposal to accomplish two major aims. First, we seek to explore the suitability of QD technology for MP-IVM. Second, we anticipate novel insights in subcellular distribution of specific molecular dynamics during interstitial migration and cellular interactions.",Combining multi-photon microscopy and quantum dot technology to study molecular dynamics on single cells in vivo,FP6,28 February 2010,01 March 2006,1403790.88 MULTISCOPE,Julius Maximilians University of Würzburg * Julius-Maximilians-Universität,health,"We propose to develop and apply novel methods of nonlinear spectroscopy to investigate the significance and consequences of coherent effects for a variety of photophysical and photochemical molecular processes. We will use coherent two-dimensional (2D) spectroscopy as an ideal tool to study electronic coherences. Quantum mechanics as described by the Schrödinger equation is fully coherent: The phase of a wavefunction evolves deterministically in the time-dependent case. However, observations are restricted to reduced 'systems' coupled to an 'environment.' The resulting transition from coherent to incoherent behavior on an ultrafast timescale has many yet unexplored consequences, e.g. for transport in photosynthesis, photovoltaics or other molecular 'nanomaterials.' In contrast to conventional 2D spectroscopy, we will not measure the coherently emitted field within a four-wave mixing process but rather implement a range of incoherent observables (ion mass spectra, fluorescence, and photoelectrons). Yet we can still extract all the desired information using 'phase cycling' with collinear pulse sequences from a femtosecond pulse shaper. This opens up a new range of interdisciplinary experiments and will allow for the first time a direct nonlinear-spectroscopic comparison of molecular systems in all states of matter. Specifically, we will realize 2D spectroscopy in molecular beams, liquids, low-temperature solids, and on surfaces including heterogeneous and nanostructured samples. Tuning the external couplings will help elucidating the role of the environment in electronic (de)coherence phenomena. Furthermore, we will combine 2D spectroscopy with subdiffraction spatial resolution using photoemission electron microscopy (PEEM). This enables us to map transport in molecular aggregates and other heterogeneous nanosystems in time and space on a nanometer length scale. Thus we access the intersection between the domains of electronics and nanophotonics.",Multidimensional Ultrafast Time-Interferometric Spectroscopy of Coherent Phenomena in all Environments,FP7,31 March 2019,01 April 2014,2669124.0 MULTISPLASH,Technion Israel Institute of Technology,photonics,"This project aims to design the first ever prototype of a plasmonic microscope for in vivo bio imaging. The principle behind the prototype consists in deep sub-wavelength focusing and raster scanning of multiple points to achieve imaging. On the one hand, using surface plasmons excitation for microscopy instead of light offers the advantage of ultra short plasmonic wavelengths (down to 100 nm) for visible light frequencies, enabling a plasmonic diffraction limit of 50 nm which sets the resolution of the microscopy. On the other hand, in this ultra short wavelength regime surface plasmons suffer losses, limiting the propagation length of plasmon waves. Losses limit the image size (field of view) to no more than 10 by 10 resolution points, a size which is completely insufficient for biological samples. The main scientific challenge of this proposal is to surpass the plasmonic losses which constitute a limitation for microscopy and most plasmonic applications. While previous attempts were based on reducing the losses (succeeded up by a factor of two), we propose a scheme that is not sensitive to these losses. The scheme consists in a 'network' of periodic plasmonic repeaters that regenerate the lossy signals, similarly to the standard method used for distributing cellular phones and TV/radio signals over long distances. In particular, we will use a Spatial Light Modulator (SLM) to create and scan multiple plasmonic foci in parallel. The image is acquired via raster scanning of all the plasmonic foci in parallel, yielding an image size limited only by the extension of the network, namely the number of pixels in the SLM. Moreover, this scheme also reduces the scanning time by up to two orders of magnitudes, making it suitable for in-vivo measurements. In conclusion, we propose a technological advancement for microscopy based on a novel scheme that can harvest the short plasmonic wavelengths for microscopy without compromising any other relevant parameters.",Multi-focal scanning plasmonic nanoscope for super resolution imaging of living cells,FP7,30 April 2016,01 May 2014,184558.0 MULTITUDES,University of Strasbourg * Universitè de Strasbourg,health,"MULTITUDES is aimed at providing multidisciplinary and multisectorial training and mobility to a very promising researcher in order to further his career development so that he may become an independent and leading scientist either in the university or private sector. The researcher will receive training in an emerging field at the interface between Physics Materials-/Nano-/Supramolecular -Science and Electrical Engineering. The research program in MULTITUDES aims to develop both asymmetrically functionalised electrodes and multifunctional devices for organic electronics. This will be achieved by modifying adjacent metal (nano)electrodes with different self-assembled monolayers (SAMs) through a process of chemisorption and selective electrochemical desorption, and will include in this some SAMs that have properties sensitive to light or that can be switched electrochemically to confer additional functionality to the surface and ultimately to the device. Within this framework, MULTITUDES aims to: - Characterise competitive adsorption processes between SAM molecules, and build a library of competitive adsorption/desorption processes between candidate molecules. - Develop protocols for fabrication of asymmetric planar electrodes by adsorption and selective electrochemical desorption of SAM molecules. - Improve control of charge injection into organic field-effect transistors (OFETs) by incorporation of asymmetric SAM functionalised electrodes. - Map the local electrical characteristics of planar OFET devices incorporating asymmetric electrodes whilst under bias using scanning probe techniques in order to improve understanding of the physico-chemical properties ruling operation with a nanoscale spatial resolution. - Fabricate novel devices for application as sensors or as multifunctional logic gates whose properties can be switched between two states through interaction of an external (non-electrical) stimulus with the SAM functionalised electrode.",MULTIfuncTional organic electronics throUgh nanoscale controlleD bottom-up tailoring of interfacES: an Intra-European Fellowship for career development.,FP7,06 May 2015,07 May 2013,202405.0 MUMID,Linköping University * Linköpings Universitet,health,"Non-invasive imaging techniques allow visualization of the dynamics and biochemical activity of pathological processes in real-time. By having proper molecular tools, a complete picture of pathologic conditions can be acquired at resolutions from the molecular level to the full body scale. Hence, smart multimodal imaging tools can be utilized for a diversity of applications, ranging from fundamental understanding of disease related events to molecular diagnostics of specific diseases. Secondly, molecular scaffolds used for imaging can also be explored as therapeutics for specific diseases, since such scaffolds are directed towards targets involved in the pathological mechanism of the disease. This project aims at developing an alternative concept for molecular imaging, diagnostics and therapy based on the chemical design of luminescent conjugated oligomeric thiophene derivatives (LCOs) which recognize distinct structural motifs instead of specific biomolecules. The LCO can for instance be utilized for specific labelling of protein aggregates, the pathological hallmark of Alzheimer's, Parkinson's and prion diseases, and for differentiation of distinct cell types, such as stem cells or cancer cells. By combining the LCO technique with other technology platforms, multimodal molecular imaging tools that can be used to gain novel insights regarding fundamental disease related biological mechanisms from the nanoscopic to the macroscopic level will be achieved. The LCO molecular scaffolds will also be evaluated as therapeutically active agents towards pathologic molecular process underlying protein aggregation diseases, bacterial infection and cancer. The main objectives of the project are; • To synthesize a diverse library of novel LCOs specific for disease related molecular targets • To develop novel LCO-hybrid materials for multimodal real time in vivo imaging of biological and pathological processes from the nanoscopic (molecular, cellular) to the macroscopic level (body, organ) • To utilize the novel real-time imaging probes for studying the pathological or biological processes associated with certain diseases, including protein aggregation diseases, such as Alzheimer's and Parkinson's diseases, bacterial infection and cancer. • To explore LCO and LCO-based pharmacophores as therapeutics towards pathological molecular process involved in protein aggregation diseases, bacterial infection and cancer. The main focus of the project is to synthesize novel molecular tools but the project has a multidisciplinary research approach and involves research disciplines such as organic chemistry, physics, biochemistry and medicine. The purpose is to provide real-time in vivo imaging agents that can be utilized for studying both the nanoscopic molecular mechanism and the macro-pathology of a diversity of biological events. In addition, the same molecular scaffold will be explored for the development of therapeutic agents. We foresee that the novel multimodal tools will be of relevance to a wide community of researchers and also of great interest to the European health care industry.","Multimodal tools for Molecular Imaging, Diagnostics and Therapeutics",FP7,31 August 2015,01 September 2010,1498800.0 MUNANOVAC,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"The MuNanoVac STREP project will assess a new vaccine strategy to prevent HIV-1 infection based on a primo-vaccination using a biodegradable synthetic colloidal carrier made of poly-lactic acid (PLA) nanoparticles covered with adsorbed antigens. The aim is to demonstrate that PLA nanoparticles are a perfect mucosal vaccine vehicle, immunogenic for both arms of immunity, adaptable to many types of antigens, easy and simple to produce. Such nanoparticle-based vaccine carriers will allow targeting dentritic cells or transporting the vaccine through skin or mucosal epithelial barriers. To amplify the mucosal immune response, the project will investigate the potential use of immuno-modulator molecules associated with different immunization routes and schedules. Six main technical activities will be conducted in the project: 1) Elaborating a standardized formulation process of PLA nanoparticles with selected HIV-1 antigens, gag and trimeric gp140 2) Identifying the best adjuvant among four candidates to potentiate the mucosal immune responses induced by PLA formulations 3) Optimizing the uptake of nanoparticles by mucosa or skin and the orientation of the immune response 4) Defining the best immunization routes and schedules of nanoparticle formulation in presence or absence of immuno-modulators for immune responses 5) Testing safety and mucosal immunity of the two best combinations in rabbits and 6) Evaluating the vaccine strategy efficacy studies with rectal and vaginal challenge routes in non human primates. Additional activities will include dissemination and exploitation of results, IPR and societal issues. The MuNanoVac project will contribute to advancing a promising vaccine approach for HIV, that could prove versatile enough for application to other poverty-related diseases e.g. Tuberculosis. With the proposed vaccine candidate, the project gives Europe a tremendous opportunity to gain leadership in the use of biodegradable nanoparticles for vaccine carriers.",Mucosal Nano Vaccine Candidate for HIV,FP6,30 June 2010,01 January 2007,1505702.0 MUNDIS,University of Zaragoza * Universidad de Zaragoza,transport,"Sensors are essential devices in today's life, for example, current vehicles can contain more than 50-60 sensors and it is foreseen that the market for automotive sensors grow to around $12bn in 2010. Contact-less technologies for sensors show the best performance properties (duration and sensitive) though their price is much higher and their industralization is much difficult because high technology equipments and installations are needed. The latest contact-less technology is based on Ballistic Magnetoresistance (BMR), a recently discovered phenomenon that shows magnetoresistance values of more than 1.000% (100 times higher than any other phenomenon observed so far) at nanocontact levels. MUNDIS project will develop an angular position contact-less sensor, using an innovative approach to BMR based on the development of Multiple Nanocontact Devices (MUNDs), which will improve performance of current contact less sensors with lower price. The sensor developed will be validated in the automotive sector, for a specific application: an accelerator pedal position sensor with these features: Durable (>10.000.000cycles), Sensitive (>800mV/V FS), Cheap (market price < 5 euros), Easy to industrialise. Integration is a key factor in the project at three different levels: .- Systems: Nanoparticles - MUND (Sensitive part of the sensor) - Angular Position Contact less sensor - Accelerator pedal position sensor. .- Technologies: micro-tech, nano-tech, magnetism, chemistry, electronics, engineering. .- Partners: ACP, SME manufacturer, will be the future mass manufacturer of the new sensor. FICOSA, automotive multinational, will integrate and validate the sensor in its accelerator pedal system. INA, university, will be mainly responsible for nanocontacs development. CSIC-LFSP, will be responsible for MUNDs development. AGH, university, will characterise the nanocontacts. IP-PRAGUE, university, will characterise MUNDs at high pressure conditions.",COMPETITIVE CONTACT-LESS POSITION SENSOR BASED ON MAGNETORESISTIVE NANO-CONTACTS,FP6,30 April 2008,30 October 2005,1350000.0 MUST,Airbus Defence and Space GmbH,transport,"The project MUST will provide new technologies based on active multi-level protective systems for future vehicle materials. “Smart” release nanocontainers will be developed and incorporated in commercial paints, lacquers and adhesive systems to prepare new products exhibiting self-healing properties. A multi-level self-healing approach will combine - in a same system - several damage prevention and reparation mechanisms, which will be activated in response to environmental conditions. The main objective of the project will cover design, development, testing and application of coated materials and adhesives used as novel multi-level protection systems for future vehicles. The new active protection systems will be based on different types of “smart” nanocontainers incorporated in polymer matrixes and adapted to the level of protection. These systems will result in a radical improvement of the long-term performance of metallic or polymer substrates. To achieve the objectives, MUST has been configured in four main activities (WP): WP2 is divided in 6 sub-projects (SP) where SP1 is technology-oriented, and concerns the production of nanocontainers.SP2 and SP3 are directed to basic research, and consider fundamental studies on self-healing mechanisms and development of simulation models. SP4, 5 and 6 consider exploitation, costs and upscaling of the most promising systems in automotive, aerospace and maritime sectors, respectively. The demonstration of the technologies will be performed together with continuous risk management in WP3. WP4 also will manage dissemination of the results and training activities and WP1 will consider the whole coordination of the project. MUST will increase considerably the life cycle of materials and therefore boost the competitive strength of the European transport industry. The multi-level protection approach will also open opportunities for the application of new light materials (magnesium and aluminium alloys) in vehicle manufacturing.",MULTI-LEVEL PROTECTION OF MATERIALS FOR VEHICLES BY “SMART” NANOCONTAINERS,FP7,09 June 2014,06 January 2008,7143481.0 MUSTANG,University of Gothenburg * Göteborgs Universitet,photonics,"My overall aim is to develop a Magnonic technology platform where Spintronic, Spin-Caloritronic and Nano-plasmonic devices and structures combine to create ground-breaking functionality from novel interactions between charge, spin, heat and light. With traditional Magnonic studies typically geared towards the low GHz range, and nanoplasmonic phenomena primarily focusing on visible light, my proposed platform will also attempt to bridge the so-called 'THz gap' and create ultra-broadband and rapidly tuneable spin wave (SW) based signal generators, manipulators, detectors, and even spectrometers, in the 10–200 GHz frequency range. I will reach this goal by transferring my documented nano-contact spin torque oscillator (NC-STO) expertise into the magnonics world of both metal and insulator based SW propagation, add recently discovered spin hall (SHE) and inverse spin hall effect (ISHE) SW manipulation/detection, and combine it with my recently acquired know-how in nanoplasmonics. My specific aims are: 1. SW generation and manipulation using metal and YIG based NC-STOs 2. SW-light/heat interaction using nanoplasmonic structures and Spin-Caloritronics 3. ISHE/SHE detection and control of propagating SWs in metals and YIG","Magnonics Using Spin Torque, spin caloritronics, And Nanoplasmonic engineerinG",FP7,31 December 2017,01 January 2013,1500000.0 MUSTWIN,Esaote SpA,information and communications technology,"Objective is to bring a major breackthrough in ultrasound transducers design and manufacturing processes with performances well beyond the standard technology of piezoelectrical transducers. Based on MEMS manufacturing process, these new devices will replace existing arrays and sensors used in Ultrasound Medical Imaging and NOT, offering bandwidth over 100% with reduced losses and lower manufacturing cost. Furthermore sensors and transducers operating above 10 MHz will be achievable in a collective way resulting in a high level of yield and reliability. Benefit for EU will be in Medical diagnosis improvment, manufacturing control with performant miniaturized sensors, and will create employements for transducers manufacturing in EU MEMS foundries instead of actual subcontracting labor in non EU countries. The work plan is using main outputs from tha growth Parmenide and the UMIC Eureka projects",Micromachined Ultrasound transducers for wide range application in Medical imaging and Non Destructive Testing,FP6,31 July 2007,01 March 2004,2245983.0 MYODYN,Curie Institute * Institut Curie,health,"Myosins are fascinating proteins with unique biochemical and physical properties. The multiple roles that they play in the dynamics of intracellular membranes are only beginning to emerge. Recent findings from the research team have highlighted unexpected roles in membrane deformation and in membrane fission played by two myosins (myosin 1b and myosin II) functioning at the interface between the Golgi, TGN (Trans-Golgi Network) and endosomes. Building on these results, we propose to establish a comprehensive model describing how several myosins work in concert with F-actin and with microtubule-based motors for sustaining transport events and membrane dynamics in a region of the cell at the crossroads of complex trafficking pathways. Towards this general objective, our main goals are: Goal 1: to understand the role of myosin 1b in membrane deformation Goal 2: to understand the role of nonmuscle myosin II in membrane fission Goal 3: to characterize the actin structures required for myosin functions Goal 4: to identify and to characterize other myosins functioning at the Golgi/TGN/endosome interface and to investigate their functional coordination Goal 5: to understand how myosins are functionally coordinated with microtubule-based motors. The function of myosins will be studied both at the cellular and physical level using two main original methodological approaches available to the research team: minimal in vitro assays (giant liposomes and membrane nanotubes) and normalized cell systems (micropatterns). This proposal represents a new development in the activity of the research team composed of cell biologists, experimental and theoretical physicists. Success of this proposal will rely on the strong experience of cross-disciplinary approaches that allowed the research team in the past to elucidate several physical mechanisms underlying transport processes and membrane dynamics.",Myosins and the dynamics of intracellular membranes,FP7,31 January 2019,01 February 2014,2500000.0 N-CHITOPACK,Mavi Sud Srl,environment,"The food sector (including beverage industry) accounts for approximately two thirds of global packaging and about 50% of these packages are made of plastics. Plastic food packaging materials currently in use are generally non-biodegradable causing ecological imbalance and aesthetic deterioration of nature. At the same time being a petro-chemical based product, plastics rely on a depleting and increasingly costly natural resource with relatively low LCA performance (high CO2 footprint).","Sustainable technologies for the production of biodegradable materials based on natural chitin-nanofibrils derived by waste of fish industry, to produce food grade packaging",FP7,10 July 2016,11 January 2012,0.0 N2P,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"Outstanding progress has been made in recent years in developing novel structures and applications for direct fabrication of 3D nanosurfaces. However, exploitation is limited by lack of suitable manufacturing technologies. In this project we will develop innovative in-line high throughput technologies based on atmospheric pressure surface and plasma technologies. The two identified approaches to direct 3D nanostructuring are etching for manufacturing of nanostructures tailored for specific applications, and coating. Major impact areas were selected, demonstrating different application fields. Impact Area 1 focuses on structures for solar cell surfaces. Nanostructured surfaces have the potential to improve efficiencies of cells by up to 25% (rel), having dramatic impact on commercial viability. Impact Area 2 focuses on biocidal surface structures. Increasing concerns about infections leading to the conclusion, that only multi-action approaches for control of infection transfer can be effective. We plan to combine such surfaces with 3D nanostructures, which will both immobilise and deactivate pathogenic organisms on surfaces. Impact Area 3 is the direct growth of aligned carbon nanotubes on electrode surfaces. The material is under investigation for use in high load capacitors which are seen as key components for energy storage systems, e.g. for Hybrid Electric Vehicle. Impact Area 4 focuses on tailored interfaces to achieve durable adhesion on polymer surfaces by 3D nanostructuring and coating. Target is to reduce energy consumption by introducing lightweight materials. The N2P partners have been chosen to ensure a strong capability to exploit and disseminate the outcomes. Involved end-user industries represent high market value segments: photovoltaics, aeronautics, automotive, steel. The consortium includes 7 technology leading SMEs and 4 multi-national industries, cooperating with 9 institutes for industrial research and a public body from 8 European countries.",FLEXIBLE PRODUCTION TECHNOLOGIES AND EQUIPMENT BASED ON ATMOSPHERIC PRESSURE PLASMA PROCESSING FOR 3D NANO STRUCTURED SURFACES,FP7,30 November 2012,01 June 2008,7400000.0 N2T2 DEVICES,Aixtron SE,energy,"Nano-templates fabricated from chemically stable, resistant materials provide a flexible basis for a range of fabrication technologies including forming, moulding, imprinting and hot embossing. The purpose of this proposal is to establish large-area novel nano-forming technologies based on patterning porous anodised alumina (Al2O3) and their application to the fabrication of organic solar cell devices, quantum dot based photonic LEDs/Lasers and photonic crystal structure elements. The specific aims are 1. To research and develop technologies compatible with semiconductor microfabrication technologies for nano-patterning using porous anodised alumina or titania thin films, to form arrays of ultra-small structures; 2. To apply porous anodised alumina nano-masking and nano-imprinting to selective area epitaxial growth, to produce GaN quantum dots of unparalleled size uniformity for enhanced light emitting devices and lasers; 3. To apply anodised nano-templates to the fabrication of novel high-aspect ratio photonic devices by nano-imprint lithography; 4. To apply self-ordered porous alumina nano-templates to the mass market fabrication of two-dimensional and three-dimensional photonic crystal structure devices in semiconductors, dielectrics and polymers. Meeting each aim will involve a detailed, multi-disciplinary programme of microfabrication and materials and device characterisation.",NOVEL NANO-TEMPLATE TECHNOLOGY AND ITS APPLICATIONS TO THE FABRICATION OF NOVEL PHOTONIC DEVICES,FP6,31 October 2009,01 August 2006,2543236.0 NABAB,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"Targeting the development of computing solutions complementing logic functions based on CMOS, the main objective of the NABAB project consists of 'demonstrating that it is possible to obtain useful computing functions as the result of a post-fabrication learning/adaptation process taking advantage of the rich functionality provided by interconnected nano devices'._x000d_",NAnocomputing Building blocks with Acquired Behaviour,FP7,12 July 2012,01 January 2008,0.0 NABIS,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"The goal of this research project is to study and develop novel synergistic technologies for the next generation of high performance biochips, for future applications e.g. in accellerated drug discovery, diagnostics and personalized medicine. One of the key technologies relies on a predictable self-organization of fluids, using both static and dynamic formats will be utilized. The formats will be combined to overcome current bottlenecks in the automation of high throughput assays, and will also be used for the development of a new concept for automated chip replication. Other complementary technologies deal with surface-expanded high density bioprobe arrays, including the use of novel polymers. Also, novel magnetic bio nanowires, controlled by an external magnetic field onto a platform of magnetic nanodots, will be explored.It is anticipated that the use of these technologies will provide unique possibilities to increase ligand density, as well as enhanced kinetics, resulting in enhanced sensitivity and faster assay performance. A third technology based on externally applied surface acoustic waves will be incorporated into the platform, yielding extremely efficient agitation of nanodroplets. Finally, a nanoelectrochemical detection system will be developed. The technologies will be combined to yield an optimized nanoarray chip, including the novel fluid agitation and bio-nanowires principles. The optimized structure will be tested using standard bioassays, and the results obtained will be compared with performance data, obtained from similar experiments with state of the art biochips.",NANOBIOTECHNOLOGY WITH SELF-ORGANISING STRUCTURES,FP6,30 June 2007,01 January 2004,2933916.0 NACARDIO,University of Gothenburg * Göteborgs Universitet,health,"Insulin resistance, the key feature of the metabolic syndrome, not only causes type 2 diabetes but also gives rise to its deadliest complications - the cardiovascular disease. A key factor in the development of insulin resistance is the accumulation of triglycerides in liver and muscle, a process that seems to be highly regulated. NACARDIO is a multidisciplinary project aiming to develop and commercialise a nano-biosensor technology, capable of analysing extremely small amounts of protein in small sample volumes. The technology can be used to quantify proteins involved in lipid storage to investigate if any of these proteins are potential biomarkers for the development of insulin resistance and cardiovascular disease. The sensor technology is based on single electron tunnelling (SET), a phenomenon well explored for low temperature applications. State of the art nanofabrication utilising metallic nanoparticles now make this technology platform available for room temperature operation. SET-technology provides unique possibilities for biosensing. Direct electrical detection can be made with sensitivity greater than for any other existing or proposed technique. To achieve the goals of NACARDIO, extensive multidisciplinary work addressing questions at the interface between nanotechnology, physics, electrical engineering, surface chemistry, biotechnology and medical sciences will be performed. Frontline experimental approaches encompassing peptide-stabilised gold nanoparticles, electron-beam lithography, nano-imprint, molecular self-assembly, engineered antibody-fragments, protein expression and fluidic simulations will be employed to fabricate the sensor and ensure biological functionality and usability. The efforts will result in a technology that not only revolutionises cardiovascular research and diagnostics, but also promotes other innovative approaches including analyses of extremely small sample (e.g. single-cell) and real-time monitoring of cell-signalling.",Nanoparticle-based electronic biosensor for diagnostics of cardiovascular disease,FP6,31 December 2009,01 October 2006,2221185.0 NAD,University of Milano * Università di Milano-Bicocca,health,"The search for effective therapies and early detection strategies for Alzheimer's Disease (AD), the major cause of dementia in Europe, is imperative. It is known that β-amyloid (Aβ) peptide plays a central role in neurodegeneration. In AD brain, Aβ is released in a soluble form that progressively becomes insoluble forming aggregates; extracellular plaques mainly composed of Aβ are a hallmark of post-mortem brains. These premises strongly suggest brain Aβ as a possible target for therapy and diagnosis of AD. In addition, it is known that brain and blood Aβ pools are in equilibrium via the blood-brain-barrier (BBB). Accordingly, it has been reported that removal of blood Aβ may withdraw the excess of brain Aβ by a 'sink' effect. Thus, blood Aβ is another potential target. The aim of this project is to utilize nanoparticles (NPs) specifically engineered for targeting brain Aβ, for the combined diagnosis and therapy (theranostics) of AD. NPs (liposomes, solid lipid NPs, polymeric-NPs) will be multiple-functionalized with: i) a large arsenal of molecules (specific lipids, antiamyloidogenic drugs, polyphenols, heteroaromatic compounds, unnatural peptides and peptidomimetics, antibodies) interacting with Aβ in all aggregation forms, ii) PET or MRI contrast agents detecting such interaction, iii) molecules stimulating BBB crossing via the transcytotic route. Several artificial and cellular models will be used to fine-tune such features and to improve NPs biocompatibility, non-immunogenicity, non-toxicity and physical stability. Eventually, absorption, distribution, metabolism and excretion will be studied using animal models of AD. Different routes (i.v., oral, nasal) and protocols (two-step, NPs cocktails, aerosols) of administration will be utilized to boost NPs brain delivery. The prediction is that NPs will detect, disaggregate and remove Aβ brain deposits. In any case, NPs will interact with blood Aβ, withdrawing the excess of brain peptide by a 'sink' effect.",NANOPARTICLES FOR THERAPY AND DIAGNOSIS OF ALZHEIMER DISEASE,FP7,31 August 2013,01 September 2008,1.092135E7 NADETOX,Technische Universiteit Delft * Delft University of Technology,health,"The progress made in improving the development and the production of nanoparticles (NPs) is enormous. Metallic nanoparticles (mNPs) are among the most widely used types of NPs in electronics, foods, containers, pharmaceutical drugs, cosmetics and paints. This trend will lead to an ever-increasing presence of NPs in the environment. This scenario means that humans and the environment will be exposed to more and more nanotechnology-based products whose health risks and environmental impacts of NPs might outweigh their benefits. In order to promote prevention and safety in manufacturing and handling of NPs, NADETOX aims at evaluating the nanodevelopmental toxicity of selected metallic cobalt, silver and gold NPs extensively used in nanomedicine for cancer therapy. This novel and multidisciplinary research project is based on the 3Rs in vitro approach (Reduction, Refinement, Replacement), involving the development of a mechanistically-based alternative method, Frog Embryo Teratogenesis Assay-Xenopus (FETAX), and the combined use of peculiar advanced spectrochemical, radioanalytical, biochemical and molecular biology techniques. These methods offer the opportunity to label NPs, avoiding surface modification, to localise and quantify them in organisms. NADETOX aims at the following goals: (i) characterisation of NPs establishing their size and morphology, (ii) study of stability and of the eventual release of metal ions from radiolabelled NPs in the reconstituted water medium suitable for the culture of Xenopus embryos (FETAX medium), (iii) evaluation of embryolethality and teratogenicity of NPs by FETAX assay, (iv) biokinetics studies to measure uptake, metabolic fate and biopersistence of NPs in Xenopus at embryo and larva stages and structure diagnosis at DNA level, to get information on the genomic stability following formation of DNA-adducts.",NAnomics in vitro DEvelopmental TOXcology,FP7,18 October 2014,19 October 2012,183805.0 NADIA,EnginSoft SpA,transport,"NADIA is co-ordinated by EnginSoft, Hi Tech SME, and addresses multi-level S&T objectives: 1. Engineering & Production: Proof-of-concept light alloy multifunctional components for the transport industry 2. Applied RTD: Multi-scale design & simultaneous engineering tools; Processing solutions; Procedure & standards for components 3. Basic Research: models of nano-scale phenomena in alloys & nano/micro structure effects on properties; Alloying elements effects on components behaviour; Optimised nano-size powders for coatings NADIA is fully integrated: Vertically (over entire value-chain), Horizontally (S&T multi-disciplinary nature), on Activities & Partnership, European, Financial. Materials, processes, new simultaneous engineering tools will lead to production of transport demonstrators. The work-plan has 8 WPs: - WP1 Multi-scale tools for design and processing - WP2 Nano- & micro-scale phenomena - WP3 Nano- & micro-scale properties - WP4 Knowledge-based component demonstrators - WP5 Component behaviour - WP6 Training for Design & Production - WP7 Innovation, Exploitation & Dissemination - WP8 Integration & Management The 12 SMEs are alloy producers (Metalli Capra, MBN), equipment suppliers (LPM), engineering & design companies (Enginsoft, Magma, Foundrysoft, Matfem), foundries (Asmet, Tenhults), coating suppliers (Thermico), components assemblers (Abamotor). RTD centers (Sintef, CRF, IPPT, Tekniker) and Universities (Trondheim, Padova, Helsinki, Joenkoeping) will focus materials, processes & engineering. Large industries are those strictly needed: primary alloys producers (Hydro), car manufacturers (DaimlerChrysler, Ford), special technology foundry for transport components (TeksidAluminum).",New Automotive components Designed for and manufactured by Intelligent processing of light Alloys,FP6,30 April 2010,01 May 2006,7196910.0 NADINE,Technical University of Denmark * Danmarks Tekniske Universitet,health,"Medical diagnosis is currently undergoing a major revolution due to the fast discovery of molecular biomarkers, and the development of multimodal 'metabiomarker' signatures. Progress, however, is hindered by low abundance of many biomarkers of interest in body fluids, in absolute concentration and with regard to other biomolecules. The aim of the present project is to apply these progresses in biotechnology, nanoparticle synthesis, and nano-instrumentation to the development of fully integrated lab-on chip instruments able to perform elaborate multimodal biomarker analysis on a routine basis and at the ultrasensitive level required to allow minimally invasive tests. In particular, we aim at overcoming a major bottleneck on the path to this objective, which was identified in a previous project in the 'HEALTH' priority: no satisfactory solution currently exists to bridge the several orders of magnitude between the nanoscale volumes at which ultrasensitive new generation sensors operate, and the often millilitre volumes of samples in which the molecules of interest must be found. For this, we shall combine innovations in pre-concentration, micro and nanofluidics, self-assembly, micro-nanofabrication, and nanodetection. The project will develop a generic, multipurpose, platform of compatible enabling technologies, and integrate them into devices. In order to maximize impact and societal benefit, the project will be validated on an application of major interest for health, namely the early detection of biomarkers for neurodegenerative diseases (including Alzheimer), with special emphasis on subtyping of these diseases for improved treatment strategies. The consortium includes a multidisciplinary group of technology developers, three leading biomedical groups in clinical neuroscience for definition of specifications and end-user pre-clinical validation, and three research-oriented SMEs in biotechnology, nanosensing and microfluidics.",Nanosystems for the early Diagnosis of Neurodegenerative diseases,FP7,31 August 2015,01 September 2010,9000000.0 NAIMO,Free University of Brussels * Université Libre de Bruxelles,energy,"Short description : NAIMO will develop new multifunctional materials that are processed by solution-based additive manufacturing (e.g. direct printing), under quasi-ambient conditions, so that a set of materials can be added onto a wide range of structural substrates, to form a composite material with designed multifunctionality in an environmentally-friendly way. A key outcome of NAIMO will be the set of materials, process and manufacturing capabilities to transform a plastic film substrate into a multifunctional composite (with designed electronic, optical, sensing and magnetic capabilities) by a series of additive manufacturing steps. This solution-based manufacturing approach will enable control of structure on a nanometre scale. NAIMO will build on the important advances made by the Partners in the use of molecular materials (including conjugated polymers) for low-cost large-area electronic and optical applications. Major impacts : 1) NAIMO will create the scientific and technological foundations and the societal environment needed to create a new industry of thin-film multifunctional materials. 2) The NAIMO research program is anticipated to lead to major fundamental advances in materials design, synthesis, process techniques and manufacturing tools. 3) Besides improving the competitiveness of European industry, NAIMO will also contribute to the development of new products, such as organic electronic integrated circuits and displays, sensors, flexible solar cells, and magnetic structures that will directly benefits to the health, welfare, security and environment of the European citizens.",NAnoscale Integrated processing of self-organizing Multifunctional Organic Materials,FP6,31 March 2008,01 April 2004,1.49E7 NAMASEN,University of Antwerp * Universiteit Antwerpen,health,"We identify Neuroelectronics as a novel mature discipline, at the boundaries between neurobiology, electrophysiology, computational neurosciences, microelectronics, materials sciences, and nanotechnologies. In the proposed Marie-Curie consortium, each of these components, as well as the specific application contexts (i.e. basic research, neuroprosthetics, and pharmaceutical applications), are represented and combined in a concerted effort, towards the training of a new generation of researchers and professionals. We target both technological priorities, such as the development of novel multi-electrode arrays and advanced interfaces that functionally interact with neurons and networks; and scientific priorities, considering and studying neuro-electronic hybrids as devices able to undergo a functional and anatomical reconfiguration, on the basis of the activity-dependent plasticity and rewiring properties of neurons, under some control of the experimenter. Our ultimate aim is to lay the foundation of a virtual institute for the multi-disciplinary study of neuroengineering and network-neurosciences that will train a new generation of scientists and professionals and that will contribute to Europe's leading role in scientific innovation. We strongly believe in the unique training potential of our consortium: neuroelectronics to analyze and synthesize neuronal networks, using artificial devices able to co-operate with neurons, thereby crossing the barriers between artificial devices and neurons. Knocking down the barriers between natural and artificial is, in the words of Edoardo Boncinelli (founding figure in developmental biology and 2005 EMBO Awardee for Communication in the Life Sciences), 'a fantastic crossing between biological evolution and cultural evolution, a shortcut between culture and nature'.",Neuroelectronics and nanotechnology: towards a Multidisciplinary Approach for the Science and Engineering of Neuronal Networks,FP7,30 September 2015,01 October 2011,2906854.0 NAMASOS,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,manufacturing,"This project aims at developing a technology for the production of highly ordered patterns of nanomagnets, based on self-organised processes. The dimensions of the individual magnetic dot structures in the nanometer regime promise ultrahigh densities of single domain magnets usable for magnetic ultra-high density storage. Two promising self-organised fabrication approaches of ordered nanomagnet arrays are developed in this project. The first approach uses a multi-layered structure, consisting of a thin (<5nm) magnetic layer, embedded between two GaSb-semiconductor layers. The top GaSb layer is eroded in a normal incidence ion sputtering process, producing a hexagonally ordered dot pattern. As the ion erosion process proceeds into the metal layer a hexagonal ordered metallic nanopattern emerges with dimensions in the range of 15 to 100 nm. The second approach based on SiGe substrates, which are covered by a checkerboard-like pattern of pyramids, formed during controlled growth of SiGe-alloys. Deposition of magnetic material under normal or grazing incidence results in a formation of a pattern of magnetic islands. The size of the individual pyramidal structures can be varied in the lower nanometer range. In addition to the process know-how for the fabrication of these magnetic nanodots, a large body of nanoanalytic investigation will be performed, concerning magnetic behaviour, structure and composition of the dots, accompanied by the development and tribological characterisation of protective coatings.",Nanomagnets by Self Organisation,FP6,31 December 2006,01 January 2004,1825700.0 NAMASTE,University of Nottingham,information and communications technology,"We are proposing a Collaborative Project, NAMASTE, on nanostructured dilute magnetic semiconductor and metal materials. The key ideas are to control and manipulate the nanoscale properties of magnetic materials by local strain and electric fields making possible new types of magneto-electronic and spintronic devices. This is a co-ordinated programme of theoretical, experimental and technological research by a consortium of European academic and industrial research groups, each of which is internationally leading in the complementary, multidisciplinary research fields essential to the project delivery. The proposal builds on recent advances in the state-of-the-art by the consortium members and is based on the design of materials whose specific nanostructure yields the required tailored properties. NAMASTE should significantly advance the understanding of nanostructured magnetic materials and magnetic phenomena at the nanoscale. The project has a high probability of major medium and long term impact on many aspects of spintronics, magnetic data storage and processing, and magnetic sensors.",Nanostructured Magnetic Materials for Nanospintronics,FP7,08 July 2013,09 January 2008,2299963.0 NAMDIATREAM,Trinity College Dublin,health,"NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highly specific 'lab-on-a-bead', 'lab-on-a-chip' and 'lab-on-a-wire' nano-devices utilizing photoluminescent, plasmonic, magnetic and non-linear optical properties of nanomaterials. This offers groundbreaking advantages over present technologies in terms of stability, sensitivity, time of analysis, probe multiplexing, assay miniaturisation and reproducibility. The ETP in Nanomedicine documents point out that nanotechnology has yet to deliver practical solutions for the patients and clinicians in their struggle against common, socially and economically important diseases such as cancer. Over 3.2M new cases and 1.7M cancer-related deaths are registered in Europe every year, largely because diagnostic methods have an insufficient level of sensitivity, limiting their potential for early disease identification. We will deliver •Photoluminescent nanoparticle-based reagents and diagnostic chips for high throughput early diagnosis of cancer and treatment efficiency assessment •Nanocrystals enabling plasmon-optical and nonlinear optical monitoring of molecular receptors within body fluids or on the surface of cancer cell •Multi-Parameter screening of cancer biomarkers in diagnostic material implementing segmented magnetic nanowires •Validation of nano-tools for early diagnosis and highly improved specificity in cancer research. •OECD-compliant nanomaterials with improved stability, signal strength and biocompatibility Direct lead users of the results will be the diagnostic and medical imaging device companies involved in the consortium, clinical and academic partners",NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING,FP7,30 June 2014,01 July 2010,1.1999205E7 NAME-QUAM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The Project investigates ultracold atom/molecule quantum matter technology for quantum information computational tasks. Our efforts concentrate on atoms/molecules confined in periodic nanostructures, either externally imposed by optical lattices, or self-generated by atomic/molecular interactions. Parallel quantum processing in periodic nanostructures is expected to lead to significant advances in different areas of quantum information. The Project aims at developing novel techniques for quantum engineering and quantum control of ultracold atoms and molecules confined in the periodic nanostructures. An innovative aspect is the development of appropriate tools for achieving quantum control of strongly correlated many body systems at the nanoscale by exploiting moderate- and long-range quantum mechanical interactions. Strongly correlated interacting systems offer a level of computational power that cannot be reached with traditional qubits based on spin, or hyperfine atomic states. Moderate and long, range interactions will be exploited in few body quantum systems in order to produce fast quantum gates using novel robust qubit and/or qudit concepts and using quantum states with topological order, all of them highly relevant for next generation quantum information implementations.",Nanodesigning of Atomic and MolEcular QUAntum Matter,FP7,12 July 2013,01 January 2009,0.0 NAMETECH,Flemish Institute for Technological Research * Vlaamse Instelling voor Technologisch Onderzoek (VITO),environment,"The Nametech project harnesses benefits of nanotechnology to bring about improvements in membrane filtration for advanced water treatment. The general objective is to strengthen the European membrane market by making nanotechnology available to large scale European membrane manufacturers. A unique feature of the project is the knowledge transfer between the experienced membrane manufacturer Norit and the coating expert and new-comer to the membrane field Agfa Gevaert. The S&T focus is on the use of nano-structured materials to alter the physical and chemical properties of polymeric ultrafiltration membranes and thereby improving the filtration performance at macroscale installations. The project aims at adapting commercial nanoparticles such as TiO2 and Ag for the modification of UF membranes to reduce fouling, and thus improve its permeability (i.e. Technology Path 1). In Technology Path 2 and 3, the potential of using active nanoparticles, such as bionano-catalysts, in combination with membranes is examined to remove micropollutants such as chlorinated compounds, nitroaromatic compounds or redox active metals, thus improving the water quality. A specific novelty is the development of an integrated permeate channel concept, whereby the nanoparticles are embedded in 3D textiles, functioning as membrane support and permeate channel. The nanoparticles will be deposited on the membrane surface or embedded in the membrane (mixed matrix). The S&T challenges regarding the modification of the nanoparticles, the deposition of the nanoparticles on membrane surface as well as the production of nano-activated membranes (NAMs) will be addressed in WP 1, 2 and 3. The newly developed NAMs will be tested at laboratory scale (WP 4) before selecting the most promising concept for testing at pilot scale (WP 5). The activities will be complemented by a toxicological study and the application of LCA to assess the environmental impacts (WP 6). The high industrial involvement puts a strong focus on the exploitation strategies and handling IPR issues (WP 7).",Development of intensified water treatment concepts by integrating nano- and membrane technologies,FP7,05 July 2014,06 January 2009,1930800.0 NAMIC,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"Short summary: The ability to measure structures with nanoscale resolution continues to transform physics, materials science and life science alike. Nevertheless, while there are excellent tools to obtain detailed molecular-level static structure (for example in biology), there are very few tools to develop an understanding of how these structures change dynamically as they fulfill their biological function. New biologically-compatible, high-speed nanoscale characterization technologies are required to perform these measurements. In this project, we will develop a nanowire-based, high-speed atomic force microscope (NW-HS-AFM) capable of imaging the dynamics of molecular processes on living cells. We will use this instrument to study the dynamic pore-formation mechanisms of novel peptide antibiotics. This increase in performance over current AFMs will be achieved through the use of electron-beam-deposited nanogranular tunneling resistors on prefabricated nanowire AFM cantilevers. By combining these cantilevers with our state of the art high-speed AFM technology, we expect to obtain nanoscale-resolution images of protein pores on living cells at rates of tens of milliseconds per image. This capability will open a whole new arena for seeing nanoscale life in action.",Nanowire Atomic Force Microscopy for Real Time Imaging of Nanoscale Biological Processes.,FP7,30 November 2017,01 December 2012,1264640.0 NAMICEMC,Istituto Nazionale di Fisica Nucleare (INFN),information and communications technology,"The remarkable properties of high-surface area carbons, compatible in that with carbon nanotubes, provide a tremendous opportunity for fabrication, even at very low filler concentrations, of composites with outstanding electrical and electromagnetic properties. Due to their multifunctional properties, carbon/polymer composites can be widely used as relatively low weight and ultra-thin effective electric and optical components, as well as electromagnetic (EM) shielding and absorbing coatings. At the same time, ultra-lightweight carbon foams, being highly conductive, are expected to have very high EM shielding ability due to their cellular structure. Moreover, carbon foams have extremely low cost, and demonstrate outstanding thermal insulation / fire resistant and good mechanical properties. Along with polymer/carbon composites and highly conducting porous carbon monoliths, one more very attractive object for investigation its electromagnetic properties is ultrathin carbonaceous film - pyrolytic carbon or a few layer graphene. We expect that they could absorb up to 50% of the incident micowave power despite the fact that their thickness is only a small fraction of the skin depth. The idea of the project is to provide comparative study of EM shielding effectiveness of carbon foams, carbon ultra-thin films and epoxy/carbon composites with low filler concentration in microwave frequency range and to support the experimental data with an adequate theoretical model of materials’ electromagnetics. On the basis of our theoretical simulations and experimental database collected within the project implementation, we intent to contribute into solution of one of the most challenging problem in material science: to develop EM coating through design-oriented-approach.",NANO-THIN AND MICRO-SIZED CARBONS: TOWARD ELECTROMAGNETIC COMPATIBILITY APPLICATION,FP7,12 July 2019,01 January 2014,76000.0 NANBIOPTIC,University of Hamburg * Universität Hamburg,photonics,"Emphasis is put worldwide on the investigation of fluorescent semiconductor nanoparticles NPs (quantum dots). Some of the most profusely investigated materials are cadmium selenide CdSe and cadmium sulphide CdS. As a result, a great knowledge on synthesis methods, surface chemistry, crystallinity and high photoluminiscent properties yields are on stage. These materials are best suitable for high fluorescence quantum yields, photostability, and colour control by size quantisation. The research programme of this proposal will concentrate on the synthesis CdSe/CdS core-shell nanoparticles in different configurations and the exploration of the photoluminescence properties in different environments for technological applications. In particular, CdSe/CdS core-shell NPs either in spherical or rod-like shell will be synthesized. The former particles will be studied as fluorescence labels for biomedical applications and the effect of the latter will be explored in a 2D and 3D photonic environment out of microsphere arragements. Further step will involve the use of these CdSe/CdS photonic structures as the active layer in a light emitting diode (LED). The purpose of the proposal is to explore the potential applications of high quality optimized semiconductor NPs from biomedicine to optics. The present project represents a multidisciplinary scheme gathering semiconductor nanoparticles in both biological and photonic environments with very promising applications. The objectives proposed on this project properly fit with the needs of the European Union to carry out world-class research by the availability of skilled researchers and their capacity to produce, transfer and utilize knowledge.",Applications for semiconductor nanoparticles: from biomedicine to optics.,FP6,31 August 2008,01 December 2006,149722.48 NANCORE,LM Wind Power AS,energy,"The project objective is to design a novel and cost-effective microcellular nanocomposite foam, with mechanical properties comparable to or better than Balsa wood and PVC foam, allowing for a substitution of these as core materials for lightweight composite sandwich structures. The material will be applicable for widespread industrial use, e.g. within Wind Power, rail, shipbuilding and automotive industries. The project addresses the call objective of developing polymer nanocomposites exhibiting radically enhanced properties and will involve scientific/technological tasks related to the development of microcellular nanocomposites, the structural scale of sandwich structures as well as the structural and mechanical analysis of the new material. Demonstration activities within the project will aim to validate the potential of the material for industrial use within different industries, with special emphasis on Wind Power through the full-scale static testing of a demonstrator blade.",Microcellular nanocomposite for substitution of Balsa wood and PVC core material,FP7,30 November 2012,01 December 2008,5397297.0 NANDOS,University of Gothenburg * Göteborgs Universitet,photonics,"Self-organisation of nanostructures is an attractive way to fabricate nanodevices. A variety of self organised ZnO nanostructures have been realised recently (nanopillars, nanowires, nanobelts, ..) that could have novel applications in optoelectronics, sensors, transducers etc. ZnO is a wide bandgap semiconductor with a record value of exciton binding energy and extremely large oscillator strength, which make it a good candidate for UV nanophotonics at room temperature. Oxides can also be used for gas sensing applications and the large surface area of nanostructures is one of their attractive aspects in this regard. ZnO based devices will find their application in areas such as communication, security environment or biomedical sciences. ZnO based nanodevices can be fabricated on a variety of substrates, including silicon or flexible polymer, which makes them compatible with existing silicon technology and organic electronics and optoelectronics. The objective of this project is to develop and optimise ZnO nanostructures that will give rise to a variety of nanodevices. Among the many potential applications, we have chosen to demonstrate devices in one specific sector, optoelectronics, with a particular emphasis on lighting technology. For this purpose, we will: (1) Grow self-organised ZnO based nanostructures on various substrates, such as sapphire, silicon, as well as polymer substrates, by different techniques, (2) Optimise the control of self-organisation in terms of position, distribution, orientation, size, shape, electrical conductivity, radiative quantum efficiency, (3) Demonstrate ZnO nanodevices comprising: light emitting devices (nano-LEDs), in the UV as well as for white light emitters, ZnO nanolasers operating at room temperature. (4) Optimise fabrication processes in view of achieving compatibility with existing and emerging industrial production techniques.",Nanophotonic and Nanoelectronic Devices from Oxide Semiconductors,FP6,31 January 2009,31 July 2005,2500000.0 NANEL,University of Aveiro * Universidade de Aveiro,energy,"The NANEL joint exchange project aims to establish long-lasting research cooperation between Portuguese, Bulgarian, Belgian, Belarusian and Russian scientists in the field of electrochemical synthesis of advanced nanostructured materials. The collaborative consortium joins together a critical mass of the expertise available in the involved groups. The partners bring the complementary experiences and experimental facilities which are essential for effective development and testing of the nanomaterials for to be applied in sensors and photovoltaics. Mutually beneficial transfer of knowledge will be implemented through an intensive exchange program between six partner organizations. The main technical objective of the project is development of novel functional nanomaterials for sensors and solar cell applications on the basis of ordered nanoporous anodic oxides. The main scientific novelty of the project is functionalization of the porous anodic oxides, such as alumina or titania based ones, via electrochemical or electrophoretic ways using non-aqueous electrolytes. Ionic liquids and molten salts will be used as prospective candidates for the electrolytes. The electrochemical synthesis of nanomaterials has several important advantages because of relatively low costs and fine control of the process parameters. The suggested approach will confer creation of new ordered functional nanomaterials via electrochemical routes which are not possible in water-based electrolytes. Use of non-aqueous solution confers significant advantages for specific materials which are not stable in presence of water or can not be electrodeposited because of the relatively narrow electrochemical window of water.",Functional ordered NANomaterials via ELectrochemical routes in non-aqueous electrolytes,FP7,31 December 2014,01 January 2012,250800.0 NANEX,Institute of Occupational Medicine,environment,"Nanotechnology is a fast growing industry producing a wide variety of manufactured nanomaterials (MNMs) and numerous potential applications. Consequently, the potential for exposure to humans and the environment is likely to increase. Human exposure to MNMs and environmental release of these materials can occur during all the life cycle stages of these materials. For each stage of the life cycle of an MNM, exposure scenarios will need to be developed that effectively describe how exposure to humans and the environment occur and what measures are required to control the exposure. The aim of the NANEX project is to develop a catalogue of generic and specific (ocupational, consumer and environmental release) exposure scenarios for MNMs taking account of the entire lifecycle of these materials. NANEX will collect and review available exposure information, focussing on three very relevant MNMs: (1) high aspect ratio nanomaterials - HARNs) (e.g. carbon nanotubes); (2) mass-produced nanomaterials (e.g. ZnO, TiO2, carbon black); and (3) specialised nanomaterials that are currently only produced on a small scale (e.g Ag)). The exposure information will include both quantitative (measurement results) and qualitative contextual exposure information (risk management measures). We will also review the applicability of existing models for occupational and consumer exposure assessment and for environmental release from these scenarios. We will carry out a small number of specific case illustrations and carry out a gap analyses of the available knowledge and data. Finally, we project knowledge will be disseminated to relevant stakeholders, taking into account other relevant activities that are taking place in this field.",Development of Exposure Scenarios for Manufactured Nanomaterials,FP7,11 June 2012,12 January 2009,951876.0 NANO RF,Thales SA,information and communications technology,"From the strategic agendas of ENIAC,EPoSS and ITRS it is evident that wirelessapplications are gaining more and more importance that results to new requirements in terms of miniaturization and increased complexity.The limitations of Moore’s Law in term of physics but also in terms of manufacturability, flexibility and multi-functionality has motivated research and development to implement new technologiesand new wireless architectures identified as Beyond CMOS and More than Moore.Carbon nanotubes are featuring very attractive intrinsic multi-physic properties. These properties coupled with CMOS compatibility offer promise for a new generation of smart miniaturised systems for wireless communications.Graphene also exhibits impressive electrical and mechanical properties.CMOS compatible microwave graphene devices, still at their infancy, hold promise for extremely low noise and high speed communications.The coordinator (TRT) is one of the major world players in civilian & professional electronics.TAS is N°1in Europe and N°3 worldwide for civil and military aerospace products. One key area for their products is T/R front-end systems for applications like radars for which long term solutions are continuously sought after.The main concept of NANO-RF is the development of CNT&graphene based advanced component technologies for the implementation of miniaturised electronic systems for 2020 and beyond wirelesscommunications and radars.The major objectives of NANO-RF are the development of: Active components from CNTs&graphene Passive components from CNTs& grapheneCapacitive RF NEMS from CNTsCNTs based vertical interconnectsCNTs & graphene based ICsThe developed components and technologies will be implemented in the following demonstratorsReflect array antennae for wake vortex and weather radars and Graphene receiver moduleThe demonstrators will exhibit the reconfigurability, systemability, integratability and manufacturability of thedevelopedtechnologies and unify advanced",CARBON BASED SMART SYSTEMS FOR WIRELESS APPLICATIONS,FP7,08 July 2017,09 January 2012,4345000.0 NANO ROAD SME,Steinbeis Innovation gGmbH,health,"In the next ten years scientific developments in the field of nanomaterials will influence many different industrial branches e.g. automotive, aeronautics, mechanical engineering, medical systems or health. In these industrial sectors many SMEs are involved as traditional suppliers, start-ups or producers of high tech products. In order to remain competitive on these markets, the companies have to integrate these new results in their commercial vision for future products. The project NANO ROAD SME will develop technology roadmaps in the domain of nanomaterials comprising the latest high level scientific results by using a dynamic and holistic approach. Their functions will be to identify trends in research and development and to associate them to product and application visions. They will outline, which of them are technically and economically promising or possess high potentials for problem-solving and where potential risks and relevant investigation requirements are assumed or social discussion requirement could prevail. In a second step these roadmaps will be adapted to the SME industrial culture in order to facilitate the integration of the European RTD results for nanomaterials in the different industrial branches. The project involves well-known European research organisations and networks, which are leaders in the domain of nanomaterials, European experts in the development of technology roadmaps and organisations specialised in the knowledge transfer to the industry and especially to SMEs. The project has a large European dimension. It involves 12 organisations from 7 European countries including one Candidate country. The project 'Nano Road SME' is a pilot initiative which will develop technology roadmaps and use them to facilitate the transfer and integration of European RTD results from the nanotechnological field (especially nanomaterials) to SMEs.. The main challenge is to encourage a knowledge based approach in #",Development of Advanced Technology Roadmaps in Nanomaterial Sciences and Industrial Adaptation to Small and Medium sized Enterprises,FP6,31 March 2006,01 April 2004,1099741.0 NANO UB-SOURCES,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The key objective of this project is to develop optical broad bandwidth sources using the unique properties of multilayer quantum dots structures and nonlinear photonic crystal fibres for bio-photonics applications. The proposal presents a unique synergy between nanotechnology, information science and technology and life sciences. The source development is targeted at biomedical applications such as: * Optical coherence tomography (OCT): an emerging, non-invasive, imaging technology for diagnosis (age macular degeneration; skin cancer) * Medical instrumentation based on spectroscopy For OCT in particular, the lack of optical bandwidth in available commercial technology is the main bottle-neck in achieving ultra-high resolution imaging systems. Addressing this issue enables successful penetration of this important diagnostic tool into hospital clinics. To overcome this bottle-neck, we propose to develop a breakthrough technology based on innovative concepts. The core technology development in the project is based on the most recent scientific advances in quantum dot materials. The use of these nanoscale strained islands provides the unequalled advantages of access to wavelengths and to broadband gain spectra not reachable by quantum well technology, thus overcoming the limiting bottle-neck of current laser sources. Two pathways will be investigated for achieving large optical bandwidth with sufficient power levels together with high beam quality and low noise: * Quantum dot (QD) superluminescent diodes and wavelength multiplexed QD superluminescent diodes * High peak power, pulsed QDs lasers, based on mode locking, for the pumping of nonlinear photonic crystal fibres to achieve significant spectral broadening The resulting developments from this project will enable unprecedented early diagnosis of diseases that are worldwide leading causes for blindness, cancer diagnosis of neoplastic changes and real time therapy monitoring in dermatology.",Ultrabroad bandwidth light sources based on nano-structuring devices,FP6,31 January 2009,31 August 2005,2199971.0 NANO-ARCH,Istituto Italiano di Tecnologia (IIT),photonics,"Nanoscience promises innovative solutions in a large variety of sectors, ranging from cost-effective optoelectronic devices to energy generation, and to highly performing materials and interfaces. Realizing this promise will rely heavily on a bottom-up approach. This can only succeed if self assembly of advanced nanoscale building blocks will be developed intensively, to enable creation of useful macroscopic architectures. The unconventional assembly of nanocrystals towards functional materials is the area where this proposal aims at providing a key contribution. This will be achieved via ground-breaking advances in the fabrication of shape controlled nanocrystals, via solution approaches, in their organization following radically new concepts and in the study of their assembly related properties. The bottom line here is to tune the assembly process of nanocrystals so as to generate a desired functionality or a combination of functionalities. This would represent a dramatic leap forward from the trial-and-error approach to controlling the various properties that is currently prevalent in many of the communities working in the field of nanocrystals. The primary motivation of this proposal is therefore to correlate strongly the structural properties with the behaviour of nanostructured assemblies. This is clearly a cutting edge research program, at the frontier of chemistry, physics, materials science and engineering, and whose successful outcome will be of tremendous benefit in several fields.",Assembly of Colloidal Nanocrystals into Unconventional Types of Nanocomposite Architectures with Advanced Properties,FP7,31 October 2013,01 November 2009,1299960.0 NANO-CAT,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),transport,"Many efforts have been put on the reduction of the Pt loading but nowadays a threshold seems to be obtained. Because the kinetics of the Hydrogen Oxidation Reaction is very fast on Pt, it is possible to use MEA with a Pt loading as low as 35 µgPt/cm-2 without any effect on the voltage loss when such an anode is used in front of a well working cathode. But, the Oxygen Reduction Reaction kinetics is not so fast which is the limiting step concerning the electrochemical processes in a PEMFC. For that raison, the decrease of the Pt loading is now encountering a plateau.",Development of advanced catalysts for PEMFC automotive applications,FP7,04 June 2018,05 January 2013,0.0 NANO-CHAPP,University College Cork,health,"This fellowship aims to develop the career of the researcher to the point where he is in a very strong position to start his own research group and secure funding to do so. This will be achieved by complementing his existing scientific knowledge to give him a broad and well rounded-expertise on nanopore fabrication, characterisation and applications, giving him training in complementary skills such as proposal writing, teaching and management, allowing him to build collaborations and making him well-known throughout his research field through publications, collaboration and conference attendance. A second aim of the fellowship is to transfer back to the European Union the leading scientific expertise on characterisation, modelling and application of track-etched nanopores only available at the Siwy Research Group at the University of California Irvine, USA, and to build long term collaborative links from this group and institution to the return host, the Photodetection and Imaging Research Group at University College Cork, Ireland. The scientific research and training objectives for this fellowship focus on single nanopores of diameters 2–50 nm, which are currently being explored for a wide range of applications, from single-molecule DNA analysis to biotoxin sensing to creating ionic equivalents of electronic diodes and transistors. The specific objectives are a) to advance existing knowledge on track-etched nanopores by methodically characterising track-etched nanopore properties—essential for the commercial production of these nanopores that will soon be demanded as applications develop to the practical stage, b) to construct the first ever ionic circuits, based on the ionic diodes and transistors in development at the Siwy Research Group, and c) to develop an ionic diode based specific-sequence single molecule DNA sensor capable of detecting single DNA molecules with a specific sequence, at a rate much faster than competing techniques.",Track-etched Single Nanopores: Advanced Characterisation and New Applications,FP7,30 June 2012,01 July 2009,236211.0 NANO-CORR,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"Technological advancements in the nanofabrication of semiconductor quantum devices has made it possible to realize confined few-electron systems, the so-called artificial atoms, within unprecedented correlation regimes. Experimental signatures which seem to be evidence of few-body phenomena induced by electron correlation are accumulating thanks to very recent experiments. Such investigations are strongly triggered by the possibility to use this type of electron-based devices as the basis for future electronic technologies. In particular, quantum dots based devices are at the heart of several proposal for solid-state implementations of quantum gates. In this project few-body phenomena in the highly correlated regimes which are currently being achieved in several classes of semiconductor quantum dots will be addressed. In particular, state-of-the-art, full Configuration Intearaction methods developed in the host institution will be used to simulate both transport and light scattering experiments performed by experimental partners of the host institution. Quantum dot systems which will be simulated will have a counterpart in the experimantal activities present in litarature, or will be chosen as to suit specific issues in the quantum computation context. This activity will put the applicant researcher at the center of a large theoretical-experimental collaboration in one of the most challenging and active field of current research in semiconductor physics, with important implications for future technologies.",Signatures of few-body correlations in semiconductor quantum nanostructures,FP6,31 May 2008,01 June 2006,136942.0 NANO-DESIGN,Aarhus University * Aarhus Universitet,information and communications technology,"The aim of the Nano-DeSign project is to rationally design a new generation of improved nanostructured MoS2 heterogeneous catalysts by means of computational modelling that will lead the way, in close collaboration with experimental and industrial partners, towards the engineering and use of real world desulphurization catalysts. The combustion of S-containing fossil fuels supposes a threat for the environment (acid rain) as well as for human health in largely populated and industrialized areas. Recent advances in computation and in experimental techniques allow to design and study in atomic detail nanostructured catalysts with new exciting properties that may well allow completely removing sulphur from fossil fuels. Combining the applicant’s and the host’s expertise in DFT-based methods, novel realistic models will be developed to correlate the reactivity of experimentally measured activities to the structural and electronic features of these systems. The completion of the proposed goals would significantly contribute to remediating the amount of S emitted to the atmosphere and extending the fundamental knowledge of the chemical and physical properties of S-based materials and chemical processes.",Computation-driven rational design of MoSx-based desulphurization nanocatalysts,FP7,02 May 2018,03 January 2014,221154.6 NANO-DNA,University of Southampton,health,"Solid phase DNA synthesis is certainly one of the most influential developments of the last century. Together with the understanding of DNA structure and function, not only biology and molecular genetics have advanced significantly, but also new emerging fields such as bio-nanotechnology would not have evolved. The term 'DNA architectonics' is probably most descriptive for the current directions the field of DNA synthesis is taking, where DNA becomes more and more a construction material and intelligent glue while not downgrading its importance in the life sciences. The research proposed here will evaluate novel functional DNA nanomaterials and will significantly advance the field by combining DNA nano-technology with chemically modified nucleosides, incorporating designer molecules to add specific programmed function and apply these systems to make ground breaking advances in electronics, photovoltaics and medicine.",Functional DNA nanomaterials,FP7,30 September 2015,01 October 2013,231283.0 NANO-ECOTOXICITY,Natural Environment Research Council,environment,"As a consequence of the increasing production of nanomaterials and subsequent release, there is increasing concern about their possible side effects in the environment. Due to their small size, nanoparticles (NPs) are more reactive than related non-nano materials and thus new biological effects may be expected. Metal NPs are being detected in the environment, and observations on uptake and adverse effects in organisms have already been described in the literature. Little data however, exist on the effects of NPs in soil.",Ecotoxicity of metal nanoparticles in soils,FP7,05 January 2013,05 February 2011,0.0 NANO-FCSC,Aalto University * Aalto-yliopisto,energy,"The overall aim of the Nano-FCSC project is to develop and engineer functional nanocomposite materials for a novel energy conversion technology, which combines the principle of both fuel cell and solar cell, and investigate scientific principles and device mechanisms, including ion and electron transport. Targets of the project are strongly innovative methodologies for the preparation, characterization, testing of advanced nanocomposite materials for joint fuel cell and solar cell device. This project is a multidisciplinary and interdisciplinary research encompassing nanotechnology, materials synthesis, materials characterization, thin film fabrication, device fabrication and performance test (fuel cell and solar cell) and modelling activities. Therefore, the experienced researcher will have exposure to a wide range of experts on nanoscience, fuel cell, solar cell, applied physics and modelling during the whole course of project development. Besides, Nano-FCSC project will generate new fundamental knowledge and foster new prospects and frontiers in the field of fuel cell, solar cell and nanotechnology.",Engineering of Nanocomposites for a New Energy Conversion Device Joining Fuel Cell and Solar Cell,FP7,30 April 2015,01 May 2013,207613.0 NANO-GRAPHENE,University of South Paris * Université Paris-Sud,information and communications technology,"In low-dimensional systems the strength of electronic interactions is enhanced, which can give rise to fascinating phenomena such as charge fractionalization, spin-charge separation and fractional or non-Abelian statistics. Furthermore, the effects of disorder and external factors (such as the substrate, the leads, magnetic fields, or the coupling with a gate or an STM tip), are much stronger in low-dimensional systems than in three-dimensional systems, and can greatly alter their properties. The first goal of this project is to find experimental signatures of the exotic phenomena caused by interactions, both in carbon nanotubes, and in regular and graphene fractional quantum Hall systems. The second goal is to understand how the interplay between disorder, interactions and external factors impacts the physics and the possible technological use of nanotubes and graphene in electronic nanodevices. To achieve these goals I intend to calculate theoretically quantities measurable by electronic transport, such as the conductance and the noise, in particular the noise at high-frequencies, as well as quantities measurable by scanning tunneling microscopy (STM), such as the local density of states (LDOS). Furthermore I intend to analyze and explain the recently developed STM experiments on graphene, and to propose new STM measurements that will elucidate the physics of graphene in the fractional quantum Hall regime. Some of the theoretical techniques that I plan to use are the perturbative non-equilibrium Keldysh formalism, conformal field theory and the Bethe ansatz, the T-matrix approximation, the Born approximation and numerical methods such as ab-initio and recursive Green's functions.",Understanding the Electronic Properties of Carbon Nanotubes and Graphene as Quantum Conductors,FP7,04 June 2018,05 January 2011,1041240.0 NANO-HVAC,Vento NV,health,"The NANO-HVAC project concept aims at developing an innovative approach for ducts insulation while introducing new cleaning and maintenance technologies, all enabled by cost-effective application of nanotechnology. The main concepts are: 1. Safe, high insulating HVAC-ducts enabling minimization of heat/cool losses: cost-effective, safe and extremely thin insulating duct layers that can be applied both to circular ducts (wet-spray solutions) and to square ducts (pre-cast panel). Insulation will be obtained using sprayable aeroclay-based insulating foams that can be automatically applied during manufacturing of ducts, avoiding manual operation needed for conventional materials. Such technologies, coupled with advanced maintenance systems (objective 2) will guarantee a 50% energy saving compared with conventional ducts. 2. Cost-effective pathogen and allergenic removal during operation and maintenance to reduce microbial growth: (a) development of anti-microbial, sprayable and self-adhesive photocatalytic coating, based on titanium oxide nanoparticles, for HVAC filters. (b) Development of an injectable liquid polymer matrix (epoxy resins with polyamine derived crosslinking catalyst) containing antimicrobial nanoparticles (silver oxides) for air ducts in situ maintenance activities. The liquid polymer will polymerize in situ creating a coating of thickness < 20µm which will cover the surface trapping dirt, debris and microorganisms, thus 'regenerating' the duct inner layer. The procedure may be repeated over time without affecting HVAC energy performance. Scientific and technological objectives within NANO-HVAC project can be organised in four areas: (1) high efficient and cost-effective insulation solutions for HVAC ducts (2) inhibition and removal of pathogens and allergenics (3) integration and lab scale characterization, (4) demonstration and validation. The project duration is estimated to be 36 months, with tasks organized in 9 Work Packages.",Novel Nano-enabled Energy Efficient and Safe HVAC ducts and systems contributing to an healthier indoor environment,FP7,31 August 2015,01 September 2012,2850000.0 NANO-ISLANDS,Albert Ludwigs University of Freiburg * Albert-Ludwigs-Universität Freiburg,health,"To detect foreign invaders and to communicate with other cells of the immune system, B lymphocytes carry a multitude of receptor proteins on their surface. In the past, it was thought that most of these receptors are randomly distributed on the cell surface and only become organized upon lymphocyte activation. Recent studies showed, however, that many of these surface proteins are pre-organized in nanoscale protein islands (here called nano-islands) with a size of 50-150 nanometer (nm). We have developed a Fab-proximity ligation assay (Fab-PLA) which allows us to study the organization of membrane proteins at 10-20 nm distances. With this method, we discovered that the B cell antigen receptor (BCR) of the classes IgM and IgD are located in different class-specific nano-islands. Due to the technical limitations of classical biochemistry (detergent lysis), light microscopy (diffraction limit of 250 nm) and electron microscopy (fixation artifacts), the nanoscale organization of membrane proteins is not well studied. With the Fab-PLA method, we can, for the first time, explore this unknown 200-20 nm space and analyze the composition and stability of the different nano-islands on the B cell surface. We also will develop new methods such as proximity biotinylation and proximity proteomics to better study these nanostructures and learn more about their role in B lymphocyte activation and human diseases such as lymphomas and autoimmune diseases. Although more than 50% of all drugs target membrane proteins, the nanoscale organization of these proteins is poorly characterized. To learn more about the nano-islands organization of membrane proteins is thus of utmost importance for a better understanding of the action of these drug treatments and to improve them. Our study may also provide better markers for specific disease stages and could lead to new drugs influencing nanoscale membrane processes.",NANOSCALE ANALYSIS OF PROTEIN ISLANDS ON LYMPHOCYTES,FP7,30 April 2018,01 May 2013,2244000.0 NANO-JETS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),photonics,"This project ultimately targets the application of polymer nanofibers in new, cavity-free lasers. To this aim, it wants to tackle the still unsolved problems of the process of electrospinning in terms of product control by the parameters affecting the dynamics of electrified jets. The electrospinning is based on the uniaxial elongation of polymeric jets with sufficient molecular entanglements, in presence of an intense electric field. It is a unique approach to produce nanofibers with high throughput. However, the process is still largely suboptimal, the most of nanofiber production being still carried out on an empirical basis. Though operationally simple, electrospinning is indeed complex as the behavior of electrified jets depends on many experimental variables making fully predictive approaches still missing. This project aims to elucidating and engineering the still unclear working principles of electrospinning by solutions incorporating active materials, with a tight synergy among modeling, fast-imaging characterization of electrified jets, and process engineering. Once optimized, nanofibers will offer an effective, well-controllable and cheap material for building new, cavity-free random laser systems. These architectures will enable enhanced miniaturization and portability, and enormously reduced realization costs. Electrospun nanofibers will offer a unique combination of optical properties, tuneable topography and light scattering effectiveness, thus being an exceptional bench tool to realize such new low-cost lasers, which is the second project goal. The accomplishment of these ambitious but well-defined objectives will have a groundbreaking, interdisciplinary impact, from materials science to physics of fluid jets in strong elongational conditions, from process to device engineering. The project will set-up a new, internationally-leading laboratory on polymer processing, making a decisive contribution to the establishment of scientific independence.",Next-generation polymer nanofibers: from electrified jets to hybrid optoelectronics,FP7,28 February 2018,01 March 2013,1491823.0 NANO-MAT,Bilkent University * Bilkent Üniversitesi,energy,"Bio-inspired self-assembled nanostructures comprises one of the most exciting developments in the fields of chemistry, physics, biology and materials science. These materials are vastly ordered structures with high-aspect ratio and are used as scaffolds to create chemically functionalized surfaces with control at the atomic level. The chemical properties of the materials are highly tailorable based on the choice of organic struts. These remarkable characteristics and properties have interesting applications such as photovoltaic cells, selective catalysis, adsorption, sensing, and bio-recognition. Herein, it is now proposed to extend the range of properties of self-assembled nanomaterials to encompass presentation of chemically functional groups on novel nanostructures. Our design approach relies upon hydrogen bonding, amphiphilic and metal chelating small molecules programmed to form nanostructures upon need. The work to be performed will encompass design, synthesis and characterization of self-assembled nanoscale materials in variuos architectures. Quantitative experimental studies of metal binding capability and systematic experimental use of the nanostructures will be studied for building devices for practical applications. The proposed interdisciplinary studies will accumulate knowledge that may lead to novel highly selective catalytic ensembles, chemical sensors, chemically smart coatings and alternative renewable energy products.",Self-Assembled Nanostructures for Organic-Inorganic Hybrid Nanomaterials,FP7,31 January 2013,01 February 2009,100000.0 NANO-MESO-SOLAR,University of California,energy,"Recent developments in conducting conjugated organic polymers and semiconductor nanorods (CdSe, CdTe, ZnO, TiO2) have led to the development of hybrid organic/inorganic solar cells. These cells offer the possibility of spin on deposition and low cost fabrication not possible with current silicon based cells. However, the power conversion efficiencies for the hybrid cells are reduced compared to conventional systems. Increased efficiency can only be achieved by controlling the alignment and aspect ratios of the nanorods in the organic polymer matrix. In this project, I propose to use the ordered hexagonal pore structure of mesoporous thin films (honeycomb silica structure with aligned pores 2-10 nm in diameter deposited on a substrate) to template semiconductor nanorod growth. Replacing the silica pore walls with a conductive polymer matrix by selective etch and deposition will leave a hybrid organic inorganic composite with unidirectional aligned nanorods. Additionally, pore engineering of the mesoporous films will allow aspect ration control over the included nanorods. Varying the radius of the rods can introduce a quantum confinement effect to control the band gap allowing maximum adsorption of light if the enegy difference of the band gap can be tuned to important light adsorbing wavelengths. Dimensional control over the nanorods in the matrix will both reduce charge recombination and increase charge mobility leading to significant increases in power conversion efficiency.","Inverse Templation of Semiconductor CdSe, CdTe and ZnO Nanorods using Mesoporous Thin Films: Towards High Power Efficiency Hybrid Organic/Inorganic Solar Cells",FP6,03 July 2006,04 January 2005,131457.94 NANO-MUBIOP,Hospitex Diagnostics Srl,health,"Currently, there is strong interest in the development of new bioassay techniques for gene identification, gene mapping, DNA sequencing and medical diagnostics. There are three main families of methods: Polymerase Chain Reaction, Enzyme-Linked Immunosorbent Assay and nano-particles agglutination techniques. All these methods suffer from several disadvantages as they are time-consuming and expensive, they are not quantitative and exclude multiplexing, i.e. the detection of different genotypes simultaneously. The need of a new multiplexing and quantitative bioassay technique is evident. The aim of this project is to develop a high sensitivity multiplexed platform based on a bio-non bio nanostructure able to enhance diagnostic capabilities by exploiting the dimensional shift from bio-systems to nanometric particles, thus overcoming many of the limitations of the existing methods. This method could be adapted to the detection of many kinds of bio-systems, but the project will focus on Human Papilloma Virus (HPV) responsible for cancer. The project idea is based on the development of nanoparticles functionalised with probes complementary to HPV DNA conservative region and an array of specific bio-probes for the different HPV genotypes deposited on a solid substrate. The nanoparticles will bind to the bio-system and then they will diffuse through the suspension docking to the area of the array where the probe specific for that genotype is coated. An array of nanoparticles will be created and the concentration of each HPV genotype can be quantified by estimating the number of particles bounded to each specific area. Considering the global worldwide market of the immune and genetic tests (20 Billion €) the potential economic impact can be up to 100 M€. Private/public national or local health service providers will get benefits from NANO-MUBIOP, the single test cost being about 4 € for the service provider. Last but not least, the costs will be reduced for the patients.",Enhanced sensitivity Nanotechnology-based Multiplexed Bioassay Platform for diagnostic applications,FP7,31 December 2011,01 October 2008,2512150.0 NANO-PHOTOMED,Erasmus Universitair Medisch Centrum Rotterdam * Erasmus University Medical Center Rotterdam,health,"We propose to develop multifunctional, targeted nano-photomedicines that are capable of bypassing biological barriers to deliver nano-engineered photosensitizer drugs and molecular-imaging agents to tumor tissues and angiogenetic micro-vasculature. Specifically, a unique nanomedicine system for targeted multi-spectral photodynamic therapy is proposed. The system consists of (i) luminescent quantumdot (QD) conjugated with photosensitizer (PS) drugs, which can be sensitized at its maximum efficiency using radiations of deep-tissue penetration (ii) molecular-imaging agents for the early stage detection and in situ treatment-effect analysis (iii) active targeting ligands to specifically target tumor and micro-vasculature. During the incoming phase, QDs of ZnS, Y2O3 and Gd2O3 emitting multi-spectral light under excitation with deep high-tissue penetrating radiations will be conjugated with PS so as to sensitize them at their characteristic absorption using Fluorescent Resonant Energy Transfer (FRET). The QD-PS will be combined with MRI contrast agents using `core/shell' nanotechnology and made water soluble by capping with polyethylene glycol (PEG). Finally, the nanomedicine will be connected with tumor specific ligands such as folic acid, MAbs and peptides. Optimization of nanomedicine will be carried out by studying dark and photo-toxicity in normal and cancer cell-lines in vitro. Photodynamic treatment will be carried out in pre-clinical animal models using multispectral radiations under different photo- and drug-dose conditions, followed by molecular imaging (MRI) based estimation of PDT response-dose inter-relationships. During the return phase, scanning probe imaging based investigations on the mechanism-of-activity of nano-photomedicines at intra-cellular regions leading to cell-death (apoptosis) will be investigated.",Targeted Nano-Photomedicines for Multi-spectral Photodynamic Therapy of Cancer,FP7,31 August 2009,01 September 2008,83848.0 NANO-PHOTOMED,Amrita Vishwa Vidyapeetham University,health,"We propose to develop multifunctional, targeted nano-photomedicines that are capable of bypassing biological barriers to deliver nano-engineered photosensitizer drugs and molecular-imaging agents to tumor tissues and angiogenetic micro-vasculature. Specifically, a unique nanomedicine system for targeted multi-spectral photodynamic therapy is proposed. The system consists of (i) luminescent quantumdot (QD) conjugated with photosensitizer (PS) drugs, which can be sensitized at its maximum efficiency using radiations of deep-tissue penetration (ii) molecular-imaging agents for the early stage detection and in situ treatment-effect analysis (iii) active targeting ligands to specifically target tumor and micro-vasculature. During the incoming phase, QDs of ZnS, Y2O3 and Gd2O3 emitting multi-spectral light under excitation with deep high-tissue penetrating radiations will be conjugated with PS so as to sensitize them at their characteristic absorption using Fluorescent Resonant Energy Transfer (FRET). The QD-PS will be combined with MRI contrast agents using `core/shell' nanotechnology and made water soluble by capping with polyethylene glycol (PEG). Finally, the nanomedicine will be connected with tumor specific ligands such as folic acid, MAbs and peptides. Optimization of nanomedicine will be carried out by studying dark and photo-toxicity in normal and cancer cell-lines in vitro. Photodynamic treatment will be carried out in pre-clinical animal models using multispectral radiations under different photo- and drug-dose conditions, followed by molecular imaging (MRI) based estimation of PDT response-dose inter-relationships. During the return phase, scanning probe imaging based investigations on the mechanism-of-activity of nano-photomedicines at intra-cellular regions leading to cell-death (apoptosis) will be investigated.",Targeted Nano-Photomedicines for Multi-spectral Photodynamic Therapy of Cancer,FP7,30 September 2010,01 October 2009,15000.0 NANO-PROX,Ozyegin University * Özyeğin Üniversitesi,health,"Conventional demands for development in semiconductor industry are changing as the Moore's Law approaching to its limits. Continuous decrease in the size of the transistors is coming close to atomic levels creating a fundamental barrier for further process developments as the semiconductor manufacturing is established today . Growth of thin films and inherent stress development within the film and film/substrate interface are critical for multiple phases of microelectronics manufacturing. Particularly, protective oxides of metal films are foreseen to have wide applications as (i) an interfacial layer to improve the adhesion and/or limit penetration of reactive chemicals of a deposited film (ii) as a subtractive layer to achieve selective material removal and (iii) as a nanofilm with inherent self growth limiting capability that could be used for nanoscale electronics manufacturing. Fundamental understanding of the proposed research is expected to be utilized in many other fields such as in biological systems to improve corrosion on bio-implants and, applications in which the interface and thin film properties affect permeation of reactive chemicals such as fusion reactor design or as ferroelectric capacitors where hydrogen permeation detoriates device functionality. Dr. Basim, the Principal Investigator of this study has been actively involved in semiconductor research and development for more than ten years at major semiconductor companies in US. Her expertise is on integration of newly adapted semiconductor processes, defect reduction during manufacturing and chemical and mechanical interactions on thin films. She will initiate her research at Ozyegin University, Mechanical Engineering Department with the support of the IRG funds if awarded. Dr. Basim's new appointment at Ozyegin University is expected to bring all these expertise and experience to E.U. to promote the ongoing research and development.",Nano-Scale Protective Oxide Films for Semiconductor Applications & Beyond,FP7,31 March 2014,01 April 2010,100000.0 NANO-RC,Consejo Superior De Investigaciones Científicas (CSIC),health,"The remarkable physical properties of carbon nanotubes (CNTs), have led to much interest in the potential for their application in many diverse directions. There are many examples in which the cavity of CNTs has been filled with a variety of compounds, including organic molecules, fullerenes, inorganic salts, water and metals. The aim of this project is to prepare new nanomaterials by filling CNTs and explore their potential applications. The method used to fill steam purified and opened CNT will depend on the characteristics of the material to be encapsulated, being the most commonly used routes the solution filling, melting filling and vapour filling. We propose to optimise the process for the filling of carbon nanotubes and the removal of the external material (from the filling experiment); to prepare and characterize nanoscaled materials which properties can differ significantly from the bulk material, and to fill carbon nanotubes with materials of interest for medical applications.",Preparation of novel materials by filling carbon nanotubes,FP7,31 March 2012,01 April 2009,45000.0 NANO-RF,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"CMOS scaling is the engine of the continuous improvement of digital applications. It has also been demonstrated that CMOS also offers great potential for very high speed or very low power wireless and wireline applications. This potential, together with the high levels of integration that are typical for CMOS technology, and the cost per square mm, allows RF CMOS to compete with SiGe(C) bipolar and BiCMOS and III-V (GaAs, InP) as the technology of choice for new communication demands in volume production. Therefore, it can become a main contributor to the ubiquitous communication society. However, at the same time, limitations start to appear, especially with respect to Vdd scaling, and loss of analog performance with the introduction of new materials. The 45nm node (and beyond) is not well established for digital CMOS, which makes it more difficult to assess the analog/RF performance on the level of basic building blocks. Therefore, the first objective of this project is an early assessment of the potentials of the 45nm Analog/RF CMOS options. This objective is essential for establishing a long-term Analog/RF technology development strategy. The second objective is to develop circuit topologies that cope with the low Vdd operation and possible degradations of analog/RF performance, very high frequencies or ultra low power consumption. The third objective is to deliver compact models for 45nm Analog/RF CMOS. There is a natural flow of information from technology, to models and to circuit design. Therefore, NANO-RF anticipates the need for several optimisation cycles, including the design of two test vehicles within the course of the project. This approach allows for feedback to technology and modelling based on initial circuit results.",Exploration of the potential of 45nm CMOS for Analog/RF applications,FP6,31 March 2009,31 December 2005,3270919.0 NANO-SUPRA,University of Birmingham,photonics,"Molecules are potential building blocks for new optoelectronic devices. Much research is needed in order to understand how molecules with promising properties interact to form a higher order matter, and to be able to incorporate the self-assembled material into devices with interconnections to the macroscopic world. In this framework, we propose to study porphyrin molecules. These molecules, which play an important role in biological processes such as photosynthesis and oxygen transport, are also particularly attractive building blocks for the manufacture of advanced electronic and optical devices due to their good conductivity, their interesting optical properties and their tendency to form ordered structures in the solid state. Our investigation will aim at understanding how they self-organize on various surfaces and how the molecular structure of individual porphyrin molecules and the morphology of the assembly influence the global electrical and optical properties of the structure. These results should provide information on the potentiality of porphyrin assemblies as functional structures for new devices.",Nanoscale supramolecular assemblies: Electrical and Optical Properties of single layer Porphyrin Assemblies,FP6,31 July 2007,01 August 2007,159046.4 NANO-TEC,Consejo Superior De Investigaciones Científicas (CSIC),energy,"Providing a sustainable supply of energy to the world s population will become a major societal problem for the 21st century. Thermoelectric materials, whose combination of thermal, electrical, and semiconducting properties, allows them to convert waste heat into electricity, are expected to play an increasingly important role in meeting the energy challenge of the future. Recent work on the theory of thermoelectric devices has led to the expectation that their performance could be enhanced if the diameter of the wires could be reduced to a point where quantum confinement effects increase charge-carrier mobility (thereby increasing the Seebeck coefficient) and reduce thermal conductivity. The predicted net effect of reducing diameters to the order of tens of nanometres would be to increase its efficiency or ZT index by a factor of 3. The objective of this five year proposal is to investigate and optimise the fabrication parameters influencing ZT in order to achieve a power conversion efficiency of >20%. For that, low dimensional nanowires arrays of state of art n and p-type materials will be prepared by cost-effective mass-production electrochemical methods. In order to obtained devices with a ZT >2 for application in energy scavenging and as cooler/heating devices, three approaches will be followed: a) determination of the best materials for each temperature range (n and p type) optimizing composition, microstructure, shapes (core/shell, nanowire surface texture, heterostructures), interfaces and orientations, b) advanced characterization, device development and modeling will be used iteratively during nanostructures and materials optimization, and c) nano-engineering less conventional thermoelectric like cage compounds by electrodeposition methods. This proposal aims to generate a cutting edge project in the thermoelectric field and, if successful, a more efficient way to harness precious, but nowadays wasted energy.",Nano-engineered high performance Thermoelectric Energy Conversion devices,FP7,28 February 2015,01 March 2010,1228000.0 NANO-TEC,ICN2 - Institut Català de Nanociència i Nanotecnologia,information and communications technology,"NANO-TEC seeks to build a community of academic researchers in nanoelectronics, addressing specifically research in Beyond CMOS from the combined technology and design perspectives. A methodology for continued consultation and analysis of research needs and trends will be developed. The main activity will be a workshop series with invited experts, preceded by a methodology-contents preparation phase and subsequent analysis and documentation, both by the consortium. Apart of determining what is relevant for Beyond CMOS devices and design, benchmarking and a SWT analysis will be performed. An end-of-the-project public dissemination event will present the results of the work of NANO-TEC to stake-holders, including the EC and relevant ETPs.",ECOSYSTEMS TECHNOLOGY and DESIGN for NANOELECTRONICS,FP7,02 April 2015,09 January 2010,0.0 NANO-THERMOELECTRICS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"'This proposal aims at developing new nanostructured materials with tailored thermoelectric properties. Ultimately, this may lead to the development of thermoelectric coolers and power generators of unprecedented efficiency, as well as new materials for heat sinks in microelectronics, or for thermal insulation. To achieve this goal, a multidisciplinary effort is being set forth, linking fundamental theory and experiment, together with nanomaterials’ synthesis and characterization. The present proposal focuses on the theoretical, computational and modeling aspects, and their comparison with experiment, within the larger project. This project is very relevant to the energy problems faced by the world today: thermoelectric power generation is a clean, renewable energy source, and this project may open the way to make this source into an economically viable alternative. This project is at the cutting edge of the thermoelectrics field, and involves several renowned groups worldwide in this discipline. The project coordinates efforts in all necessary aspects, from basic to applied, in order to achieve the final goals.'",Thermal and Thermoelectric Transport in Nanomaterials,FP6,14 February 2009,15 February 2007,80000.0 NANO-VISTA,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),health,"Advances in the fields of molecular and cell biology are strongly coupled to the implementation of photonic tools that allow highly-sensitive measurements in living cells at high molecular concentrations and at the nanometre scale. The goal of NANO-VISTA is to exploit novel concepts of photonic antennas to develop a new generation of bionanophotonic tools for ultrasensitive detection, nanoimaging and nanospectroscopy of biomolecules, both in-vitro and in living cells. By taking advantage of the extraordinary field enhancement, directionality and nanofocusing of photonic antennas, our approach will allow single biomolecule detection in ultra-reduced detection volumes, including living cells. The project focuses on three main objectives: a) to pioneer the development of novel photonic antennas for ultrasensitive detection in fluids and simultaneous spatio-temporal superresolution in living cells; b) to develop high-throughput large-scale nanofabrication of photonic antennas fully compatible with life science applications; c) to demonstrate the functionality of the technology for biosensing and transferability into potential market products, and for nanoimaging and nanospectroscopy on living cells. Thus, NANO-VISTA is fully targeted to the development of disruptive photonic technologies fundamental in strategic applications such as medicine and biology. To maximise the chances of success we have chosen for an interdisciplinary, trans-national and multi-institutional partnership (including a SME and a Medical Centre). True European specialists, with long standing expertise in the fields of nanophotonics, photonic antennas, large-scale nanofabrication approaches and nanoimmunologists are concentrated in this proposal strengthening European research cohesion. In the mid-long term we expect that both, cell biologists as well as industrial sectors (biophotonic, microscopy and biotechnology enterprises) will benefit from this new technology",Advanced photonic antenna tools for biosensing and cellular nanoimaging,FP7,31 October 2016,01 November 2011,3020000.0 NANO2,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),transport,"Ambient pressure oxidation determines the stability, functionality and long term performance of nanomaterials in their working environment. The NanO2 consortium will clarify, how nanomaterials behave and function under environmental oxygen conditions. The influence of the size and shape of nanoparticles on ambient pressure oxidation will systematically investigated in a revolutionary approach: Surface sensitive in-situ techniques for ambient oxygen pressures and high temperatures will be combined with ab-initio thermodynamic calculations. NanO2 brings together the specialists in Europe with unique expertise in oxidation processes as well as novel experimental and theoretical techniques. NanO2 aims to grow nano-sized Pd, Rh, Ru, and Cu particles with defined size and shape on selected oxide substrates, such as AI2O3, MgO, TiO2 and ZnO. Within four workpackages the key barriers to control ambient pressure oxidation of nanomaterials will be attacked: the influence of nano-size and -shape, the formation of sub-surface oxygen, the ab-initio modelling of the oxidation of nanosized materials at high oxygen pressures and high temperatures and nanomaterials-substrate interaction including oxygen spillover effects. The control of oxidation under operational conditions is of utmost importance for the enhanced performance of catalysts involved in applications ranging from fuel cells and chemical production to electronic sensors for automotive and environmental monitoring applications. On a more general scheme, the atomistic knowledge, prediction and control, how nanomaterials behave and eventually deterioriate under environmental conditions, will bring increased security to a European society becoming increasingly more dependent on nanotechnological systems and structures. The acquired knowledge from this European project may lay the basis for further studies expanded to a whole range of nanomaterials and corrosive environments.",Oxidation of Nanomaterials (NanO2),FP6,31 March 2007,01 January 2004,1848986.0 NANO2HYBRIDS,University Faculties of Notre-Dame * Facultés Universitaires Notre-Dame de la Paix (FUNDP),information and communications technology,"Based on a very recent set of exploratory experiments performed within the consortium, this project will take benefit of the numerous plasma discharge operating parameters combined with plasma diagnostic tools, to fine tune and understand the physical properties of the treatment, and CONTROL the INTERFACIAL (chemical and structural) DEFECTS that will rule the deposition and growth of METAL NANOCLUSTERS deposited in the plasma onto CARBON NANOTUBE surfaces. Nanoclusters with selected size, shape and density, will be prepared at different (small -large) scale in RF-cold plasmas, and in atmospheric dielectric barrier discharges from different precursors (organics, colloids and salt solutions) and fully and extensively characterized for their composition and electronic properties. The technology research will be backed up by modelling and theoretical calculations on graphene sheets, on gas-nanotube, metal- nanotube and metal-metal interaction at the nanoscale in order to understand, control, select and fine tune the reactivity (sensitivity, selectivity) of the material, for one type of selected application: chemical gas sensors. One partner will design, optimize and test nano2hybrids sensors for benzene selective monitoring at the ppb level (highly usefull for oil industry) and detecting DMMP molecules (one Sarin gas model). A special effort is devoted to the integration of the tasks and promotion to the citizens, via multimedia tools, of the project in particular, but also of the nanoscience in general.",INTERFACE DESIGN OF METAL NANOCLUSTER-CARBON NANOTUBE HYBRIDS VIA CONTROL OF STRUCTURAL AND CHEMICAL DEFECTS IN A PLASMA DISCHARGE,FP6,31 March 2010,01 October 2006,1549944.0 NANO2LIFE,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"The aim of Nano2Life is to merge existing European expertise and knowledge in the field of nanobiotechnology in order to keep Europe as a competitive partner of the US and Japan and to make it a leader in nanobiotechnology transfer in 4 years time. Nano2Life is tackling fragmentation of European nanobiotech by joining 23 so far unconnected dynamic, highly specialised and competent regions and centres with experience in initiating and running nanobiotech programmes. Nano2Life aims to set the basis of a virtual European Nanobiotech Institute, focused on the understanding of the nanoscale interface between biological and non biological entities, and its possible application in the area of complex and integrated novel sensor technologies, for health care, Pharmaceuticals, environment, defence, food safety, etc. The partners have agreed on a Joint Programme of Activity (JPA) designed: . To develop joint research projects in 4 major technical platforms : functionalisation, handling, detection, integration of devices . To elaborate a joint IPR policy with a special focus on SMEs . To develop novel education and training with special emphasis on the scientific community of the candidate countries . To build a future common RTD platform with shared facilities, knowledge, methods, electronic communications and integrated management. Multi media supported communication and dissemination activities will provide thorough education and awareness of the scientific and industrial community outside of Nano2Life and the general public about the impact of nanobiotech on industry and society. This will ensure development of nanobiotech devices, material and services according to the needs of European industry and in agreement with international social and ethical standards, which will support sustainable development of the European economy in this knowledge intensive area. 175 researchers will be integrated during the 48 months duration #",A network for bringing NANOtechnologies TO LIFE,FP6,30 September 2008,01 February 2004,8800000.0 NANO2MARKET,University of Alicante * Universidad de Alicante,health,"The lack of models for technology transfer at nanotechnology developments is of increasing concern for the sector. This CSA will fulfil this gap providing guidelines for technology transfer and rules for IPR and license agreements in nanotechnology developments. To achieve these objectives, a consortium is formed by: 1) Key European research centres in different areas of nano and converging technologies, 2) Outstanding agencies for IPR advice, 3) Market analyst experts,industry associations and venture capitals, as end clients of IP. Constructing value chains of the transfer of each technology the consortium will analyse specific applications of the different areas of the nanotechnology R&D European strategy: medical applications, information technologies, energy, materials, manufacturing, instrumentation, food, environment and security. Our objective is to classify the technology application areas of nanotechnology into different clusters according to: development costs, market time, complexity of licensing, etc. In parallel, a mapping of the technology and actual and forthcoming market will be analysed according to: competitiveness, geographical area, development potential, risks etc. Specific data mining tools will help to conclude the key worldwide actors of development and commercialisation of the different technologies. Also, actual IPR cultures and technology transfer rules will be listed according to the features of their market and technology. Matching these IPR technology transfer models with the concluded value chains and market and technology mapping, will allow concluding business models and setting efficient rules for technology transfer. All models will be discussed at consortium seminars, where general algorithms are expected to be excerpted. Specific guidelines will be given for research institutions and SMEs for efficient transfer of their prototypes to the market, along with a focus for the valorization of EU FP7 funded research projects",Best Practices for IPR and Technology Transfer in Nanotechnology Developments,FP7,31 August 2010,01 July 2009,689997.0 NANO3BIO,University of Münster * Westfälische Wilhelms-Universität Münster,health,"The Nano3Bio project convenes a consortium of world renowned experts from 8 EU universities, 1 large company, and 14 SME, to develop biotechnological production systems for nanoformulated chitosans. Chitosans, chitin-derived polysaccharides varying in their degree of polymerisation (DP), degree of acetylation (DA), and pattern of acetylation (PA), are among the most versatile and most promising biopolymers, with excellent physico-chemical and material properties, and a wide range of biological functionalities, but their economic potential is far from being exploited due to i) problems with reproducibility of biological activities as today's chitosans are rather poorly defined mixtures, and ii) the threat of allergen contamination from their typical animal origin. The Nano3Bio project will overcome these hurdles to market entry and penetration by producing in vitro and in vivo defined oligo- and polymers with controlled, tailor-made DP, DA, and PA. Genes for chitin synthases, chitin deacetylases, and transglycosylating chitinases/chitosanases will be mined from different (meta)genomic sources and heterologously expressed, the recombinant enzymes characterized and optimized by protein engineering through rational design and molecular evolution, e.g. targeting engineered glycosynthases. These enzymes and genes will be used for in vitro and in vivo biosynthesis in microbial and microalgal systems, focusing on bacteria and diatoms. The bioinspired chitosans will be formulated into biomineralised hydrogels, nanoparticles, nanoscaffolds, etc., to impart novel properties, including by surface nano-imprinting, and will be bench-marked against their conventional counterparts in a variety of cell based assays and routine industrial tests for e.g. cosmetics and pharma markets. The process will be accompanied by comprehensive life cycle assessments including thorough legal landscaping, and by dissemination activities targeted to the scientific community and the general public.",NanoBioEngineering of BioInspired BioPolymers,FP7,30 September 2017,01 October 2013,8989324.0 NANO3D,University of Birmingham,manufacturing,"The overall objective of the research proposed in this document is to integrate top-down lithographic techniques which enable precise spatial patterning of surfaces from micron- to the nanoscale, with the controlled stepwise self-assembly and self-organisation of nanometer scale chemical and biochemical entities to these surfaces, to fabricate three dimensional (3D) adaptive nanostructured architectures, which have demonstratable uses, in a fashion that will allow the processes to be scaled into proto-type production methodologies. The Nano3D consortia wish to be the first to demonstrate that nanostructures on surfaces can be created via an integration of top-down and bottom-up methodologies, by the self-organisation of self-assembled molecular building blocks on nanopatterned surfaces, such that the nanostructures are able to adapt to the environment. Furthermore, the Nano3D consortia wish to further innovate in illustrating that this approach can be scaled up into a proto-type production process, such that automation and scaleability can be demonstrated. The Nano3D consortia will be innovating a new paradigm for manufacturing nanostructures on surfaces. The Nano3D proposal addresses Community socio-economic objectives from many view points. In response to the need for the transformation of industry towards higher-added value activities, one of the central objectives of the consortium is to develop new knowledge targeted towards high value-added technologies, including biotechnology, biomedicine and ICT. Successful innovations will ultimately enable new product and market development that will stimulate employment opportunities. Perhaps more relevantly, if Europe does not take its rightful place at the centre stage of emerging nanotechnology research and development for these technologies, then these industries in Europe will continue to lose market share to new competing technologies from the Americas and the Far East.",Precision Chemical Nanoengineering: Integrating Top-Down and Bottom-Up Methodologies for the Fabrication of 3-D Adaptive Nanostructured Architectures,FP6,30 September 2008,01 June 2005,2000000.0 NANO3T,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,health,"The cause of diseases is often unknown, but their origin can frequently be found at the biomolecular and cellular level situated on nm-scale. Early diagnostics combined with early intervention on that nanoscale is one of the holy grail of modern medicine. Inorganic nanoparticles are very promising agents in that respect. One of the promising biomedical applications of these nanoparticles is their use as agents for tumor hyperthermia. Hyperthermia is a form of cancer treatment that uses an elevated temperature to kill the tumor tissue. Compared to the more conventional surgical procedures, it is hailed as a less invasive approach that could be used for small, non-defined tumors. Well-designed instrumentation in combination with engineered inorganic nanoparticles that (a) possess the desired physical properties to generate a local heat and that (b) can specifically target the tumor offer immense potentials for targeted hyperthermia therapy. The overall objective of the present multi-disciplinary project is to develop and to explore various metal/magnetic nanoparticles as agents for targeted tumor therapy. To strive for this overall objective, a successful integration and convergence of different technologies at the nanoscale is indispensable. In this project, we will focus on the synthesis routes of tailor designed biofunctionalized nanoparticles for hyperthermia. This requires a profound physical and chemical characterization of the synthesized nanostructures, but the project is certainly not limited hereto. It will also include a toxicological and biological evaluation of the different nanoparticles. Hereby a detailed exploration and characterization of the interaction mechanism of the biological entities and the nanostructures will be pursued to obtain a better understanding of the phenomena occurring at the nanoscale. In addition, this project also comprises the design of advanced instrumentation that can be used for a controlled hyperthermia treatment.",Biofunctionalized Metal and Magnetic Nanoparticles for Targeted Tumor Therapy,FP7,31 July 2011,01 August 2008,3726350.0 NANO4BIO,Loughborough University,health,"The application for the FP7-PEOPLE-2012-CIG is to support a move and integration of a new academic moving to Loughborough University, UK to take up a position of Lecturer in Analytical Chemistry. The researcher to date has published 21 peer reviewed journals and has a current h-index of 9. The funding is to secure and facilitate the long term integration of the researcher building upon his years of research experience and his existing independent research which has already produced patent applications and publications. In moving to Loughborough the applicant will be positioned within a world renowned department active in the field of analytical chemistry and biomarkers detection. This research proposal outlines a new technique capable of screening biomarkers with the capability of working directly in biological samples. The benefits of monitoring biomarkers lie in their ability to reveal signs of disease before the onset of major symptoms. The proposed technique will involve synthesizing nanoparticles that will be functionalized with aptamers/ or antibodies. These functionalized particles will capture the biomarkers directly from solution resulting in particle aggregation, and in conjunction with a resistive pulse sensing technology, will allow the quick separation and detection of the analyte, creating a new diagnostic technology. The experimental details will deliver a single process capable of capturing the analyte as well as performing the initial sample purification and pre-concentration stage that screens multiple biomarkers for several diseases across a wide range of molecular weights and functionalities When combined with the support infrastructure in place at Loughborough, the award will deliver a world leading research group integrated into the EU, delivering a new diagnostic technique to enhance the European research portfolio.",Detection of Biomarkers using Nanorods and Nanopore technologies,FP7,31 August 2016,01 September 2012,100000.0 NANO4COLOR,"Tecnologia e Engenharia de Materiais, SA",health,"We all like aesthetical pleasant colors in our every day products: kitchen and bath accessories; domestic appliances; architectural, nautical or automotive fittings; electronics components; jewelry; medical devices. In fact color coatings are present in most everyday products. PVD is one of the most promising coating processes offering brilliant and decorative finishes, superior hardness and wear resistance and lack of environmental concerns. Unfortunately PVD processes lack of reliability and high costs limit the use of PVD technologies to uncolored coatings, expensive components or large series. In Nano4Color we will develop a new strategy for the production of PVD hard decorative coatings based on nanocomposite coatings consisting of a dielectric matrix with imbibed metallic nanoclusters. Nano4color will work with two hybrid technologies; RMS/Cluster Gun and RMS/HIPISM to produce nanocomposite coatings that yield tailored optical properties with a single metal/metal oxide system. Our approach will allow overcoming the last barrier associated to the use of PVD coatings with a single composition color tailored solution resulting in greater freedom for color generation; including green and red tones. In addition we intend to design new industrial coating process, which are more reliable and cost effective. Nano4Color aims at making affordable PVD coatings for the production of everyday appliances while providing an extended color palette, increased wear resistance and lower toxic emissions. Nano4Color is expected to have a big impact on the 18,000 European SMEs working on decorative coatings with an estimated value of €11,350 M. These innovations will benefit the overall surface treatment sector by reducing production costs, increasing commercial margins and addressing industrial legislations. Furthermore these advantages will also benefit the industrial manufacturers who will be able to offer more pleasant products with lower costs and environmental emissions.",Design and develop a new generation of color PVD coatings for decorative applications,FP7,30 April 2015,01 May 2013,1030000.0 NANO4DRUGS,National Institute of Health and Medical Research * Institut National de la Santé et de la Recherche Médicale (INSERM),health,"Advances in genomics have resulted in the development of new protein-based drugs. This trend will increase in the next decade. Delivery technologies for these drugs must be designed to surmount biochemical and anatomical barriers to safely permit their passage to an intended site. Targeted delivery of protein-based drugs is limited by a series of barriers, among which, three are of critical importance: 1) Rational transport of protein-based drugs across cellular membrane 2) Control of the inter- and intra-cellular routes taken by these drugs 3) Understanding of the structural characteristics of the protein-based drugs and of their targets to achieve efficiency and specificity. Advances to overcome these barriers will lead to develop new, safer and more effective drugs by reducing undesirable side effects. To that end, the Nano4drugs consortium integrates top-level teams across Europe to develop an innovative challenging frontier bio-technology device ideally suited for targeted delivery of protein-based drugs. The device consists of bio-compatible non-bleachable fluorescent diamond nano-particles that can be grafted with both cell-penetrating peptides and protein-based drugs. As a proof of concept, Nano4drugs will target microtubules in two different biological contexts, neuron and cancer. The protein-based drugs will consist of anti-microtubules peptides recently discovered in one team of Nano4Drug, and of new ones that will be tested during the STREP with the help of post-genomic computer-based system of choices designed to guide and improve the development of protein-based drugs. At the end of this STREP, Nano4Drugs will provide Europe with a better understanding of ways to overcome protein-based drug delivery barriers. In achieving its objectives, Nano4Drugs will also deliver new potential treatments for societal health diseases such as neurological degenerative diseases and cancer. Application expected will increase European competitiveness and economy.",An innovative Protein-Based Drug Delivery Device using Fluorescent Diamond Nano-Particles,FP6,31 December 2008,01 January 2006,2453000.0 NANO@ENERGY,Ben-Gurion University of the Negev,energy,"Photovoltaics and liquid fuels are poised as major contributors to the global energy market, promising cleaner, renewable sources of energy than fossil fuels. However, the technologies required to make this possibility a reality are limited by their high cost per kWh, and current share of photovoltaics and liquid fuels in the energy market is thus extremely small. One method of reducing the costs of photovoltaics lies in the use of semiconductor nanocrystals to absorb and convert solar photon energy to usable electricity and liquid fuel. Among the advantages of a nanocrystal-based design for photovoltaics are the requirement for thinner absorbing layers, the less energy-intensive refining processes, and their scalability with respect to photovoltaic production. To address these challenges, I plan to initiate a multidisciplinary research project that comprises three separate, but interrelated and complementary, parts that will be conducted in parallel. The first and the main part will be the preparation of novel hybrid nanostructures that have potential for PV and fuel cells applications. The second will focus on a systematic study of the fundamental processes of charge dynamics in the nanoscale regime. The materials and knowledge generated can then be applied in the third part of the project—development of PV and photoelectrochemical devices with scale-up potential for large-scale solar energy exploitation, and examination of benchmark properties (overall efficiency, I V characteristics, external quantum efficiency, hydrogen and liquid fuel production) of our new hybrid materials and devices. These properties will be used as feedback for the synthesis of more complex hybrid structures and for improving our device assembly methods and the choice of materials and/or composites for the devices.",Novel Design of Nanostructures for Renewable Energy: Fundamental Questions and Advanced Applications,FP7,30 September 2016,01 October 2011,1500000.0 NANO_ARCH_REVIEW,University College London,photonics,"Much world-wide effort is being devoted to research into nanoelectronic and nanophotonics devices, but less effort is being applied to examining system architectures, which might use these devices to best advantage. Such research is needed, so that present-day increases in computing power can be extended into the future. To achieve such increases will be a major technological challenge, and proactive research and planning is needed now. Some unanswered technical questions are: Can devices be assembled into ultra-high density circuits? Are any of these devices fundamentally unsuitable? Will factors such as size variations affect performance? Can manufacturing faults and transient errors be overcome using fault tolerance? Will the circuits have better performance than CMOS-type circuits? Will nanoscale circuits be cheaper than CMOS? Besides these technical questions, two other questions must also be asked: What systems research is being carried out now, and what gaps are there? - and are there enough trained people in Europe who are capable of solving these problems? Some but not all of these questions are being looked at under existing EC initiatives. We therefore propose a survey which, starting from the existing EC Nanoelectronics Roadmap, would report on existing European expertise in the following areas: 1. existing and proposed nanoelectronic/photonic devices 2. small circuits: theory and practice 3. ultralarge circuits: theory and practice 4. conventional architectural concepts 5. unconventional concepts 6. new concepts 7. known problems 8. 'system on a chip' and 3D systems 9. applications: performance requirements 10. availability and training of human resources The report will suggest topics where further effort might be applied, ranging from basic theoretical research, through device/circuit fabrication techniques, to possible training and research workshops. Information will also be provided on US and Pacific Rim activity.",A review of the status of research and training in architectures for nanoelectronic and nanophotonic systems in the European Research Area.,FP6,21 May 2004,21 December 2003,45920.0 NANOADJUST,University College Dublin,environment,"The success of novel, new technologies often depends to a large degree on the public’s risk-benefit perception. Engineered nanomaterials (ENMs) perceived risk is largely based on uncertainty as to their release and fate in the environment. The “nanoADJUST” project will develop expertise in the application of techniques and tools used to characterise and analyse the behaviour of metallic ENMs in natural aquatic media and integrate this expertise with environmental exposure modelling and risk management data requirements and processes. Data handling throughout the risk assessment (RA) process will be analysed and a statistical framework for the acquisition and management of nano-relevant data at all stages will be developed.","Metallic engineered nanomaterial in natural aquatic environments: data generation, management and integration into environmental exposure modelling",FP7,11 June 2018,12 January 2013,0.0 NANOAGENTS,Trinity College Dublin,health,"The use of nano-sized particles is a new and promising topic in Chemistry, Medicine and Materials Science. Those nanoparticles have applications in many fields, from Computer Science to Medicine and the interest and the money invested for finding new applications grows every day. Gold is a very interesting material for designing nanoparticles (AuNPs) for medical applications due to its inertness, stability, spectroscopical properties, capacity for functionalization and biological compatibility. On the surface of AuNPs can be anchored chemical species with interesting properties. Doing this, the properties of the AuNPs can be modulated at will. Hereby we propose a 24 month research project for the design and developing of AuNPs with luminiscent properties and with potential applications for therapeutic use, drugdelivery, tissue imaging and cellular signalling. The major aim will be to signal cancer tissues for early detection and treatment of this disease. The surface of the AuNPs will be functionalized with luminiscent species that will target specific types of tissues and cells. This work will be carried out by Dr. S. Blasco, a young Spanish researcher whohas recently obtained his PhD and was formed as a Supramolecular and Bioinorganic Chemist in Prof. Enrique Garcia-Espana's group in the University of Valencia, Spain. The research work contained in this proposal will be done under the supervision of Prof. T. Gunnlaugsson, a renowned expert in the field.",Surface modified luminescent and magnetic gold nanoparticles as cellular targeting agents,FP7,31 March 2015,01 April 2013,183504.0 NANOAIR,Inel SAS,construction,"There is a need for better measurement instruments for analysis of airborne particles, in particular nanoparticles. Use of powders, nanomaterials/ceramics, and nanoparticles is rising fast. Occupational health problems are present at a wide range of different work places due to airborne particulates. Toxic particles such as asbestos and silica are responsible for the majority of particle related illnesses. The overall impacts of the NanoAir project are to reduce number of deaths and illnesses caused by workplace related exposure to particles. The air pollution detection market is growing fast, as new concerns are identified especially for indoor air pollution. The market is under pressure from USA from many new high-tech solutions, and progression regarding air pollution legislation and NP industries. Thus the concept of the project is to develop a new method to analyse airborne particles, onsite, real-time and with a high quality readout. The method can identify the particle types together with the size distribution. In the project we have a new idea for the development of an improved particle sampling system, which will allow collecting particles with a high efficiency and a wide range of particle sizes, including the nano-size regime. This will allow much improved analysis results and sensitivity for a wide range of particle types and sizes. This sampling system together with a mobile X-ray diffraction analysis technique opens up for new possibilities within air quality detection, especially within the capability to analyse nanoparticles. Detection and analysis of nanoparticles may be a very crucial field in the future air quality analysis, due to a rapidly increase in use of nanomaterials and nanoparticles in building materials, paintings, cleaning products, cosmetics, etc. At the same time, new research have indicated very large potential risks for man-made nanoparticles, due to a very deep deposition in the lungs and high chemical reactivity.","NanoAir, Development of an automated instrument for real-time, on-site qualitative analysis of full-range breathable airborne particles, including nanoparticles, using XRD technology",FP7,02 April 2013,12 January 2008,1073792.5 NANOALLOY,ASM - Institute of Applied Physics * Institutului de Fizică Aplicată,information and communications technology,Purpose of the project:,Induced electrodeposition of nanostructures as nanowires and nanotubes consisting of cobalt-based multilayers for MEMS applications,FP7,03 July 2016,04 January 2013,0.0 NANOALLOY,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"Purpose of the project: This project is focused on the synthesis by induced electrodeposition of nanowires and nanotubes as multilayered structures consisting of cobalt alloys with refractory metals like Mo and W. Hereto the superfilling of nanopores present as arrays in anodized aluminium oxide (AAO), will be investigated in-depth. First proofs of principles have been recently achieved by the applicant. The background of the host institution on electrodeposition in micro-pores (e.g. vias used in microelectronics) and its modeling is a most important support to this project. Objectives of research: - To develop at the host institution the scientific insight required for the lab demonstration of the technological feasibility of the novel concept of producing nanostructures (nanotubes, nanopores) with different aspect ratios in AAO by a low cost electrodeposition from environmental-friendly aqueous electrolytes, - To transfer the scientific knowledge to a third country with the objective of nurturing present collaboration and to explore the possibility of further collaboration between researchers and industry inside and outside EU, - To train an experience researcher from a developing country by a European specialist on electrodeposition and tribological testing. Expected research results: - The electrodeposition of cobalt-based homogeneous and multilayered nanotubes and nanowires engulfed in anodized aluminium, and as free-standing products after release from anodized aluminium. - Scientific insight on the role of electrochemical parameters on structural and functional properties of electrodeposited nanotubes and nanowires either engulfed or released from anodized aluminium. - Mapping of the functionality of nanotubes and nanowires made of compositionally modulated layers in view of future applications in MEMs and NEMs technology as wear resistant and/or electro-magnetic materials. .",Induced electrodeposition of nanostructures as nanowires and nanotubes consisting of cobalt-based multilayers for MEMS applications,FP7,09 June 2014,10 January 2010,158600.0 NANOANTENNA,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The main goal of our proposal is to develop a novel optical nanobiosensor based on extraordinary vibrational signal enhancement of the proteins to be detected. To reach vibrational signal enhancement, we will exploit the optical properties of specially designed metallic nanoparticles which should act as nanoantenna and the associated field enhancement to obtain a direct detection of proteins bound to the nanoparticle. Thus, our sensor will reach high sensitivity provided by the recently established large enhancement of vibration signals due to the resonant excitation of the nanoantenna device used as substrates. The aim is to detect only a few proteins with concentration much lower than 1pM and finally to reach detection threshold such as femtomole or lower. High molecular selectivity will be reached with the functionalisation of the nanoantenna. Such functionalisation will selectively favour the immobilisation of the protein to be detected at the vicinity of the nanoparticle surface, providing the best enhancement and then the detection of the targeted protein. Our nanobiosensor will include two main components: the nanoantenna device which corresponds to our sensor transducer and the functionalisation which corresponds to its bioreceptor. And then, each functionalised nanoantenna device used as vibrational signal enhanced system is an individual and specific nanosensor of proteins. As a consequence, our nanobiosensor integrated in a vibrational spectroscope will allow the detection and the analysis of the enhanced vibrational signal from the targeted proteins and thus corresponds to our diagnosis instrument. Our nanobiosensor will be validated on the detection of proteins on body fluids.These proteins have been chosen since they have been identified as specific biomarkers of common pathologies. This validation will be applied it to improve their detection (better sensitivity, decrease of the detection threshold) and open the way to the early diagnosis.",Development of a high sensitive and specific nanobiosensor based on surface enhanced vibrational spectroscopy dedicated to the in vitro proteins detection and disease diagnosis,FP7,31 March 2013,01 October 2009,3999925.0 NANOANTENNAS,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Nano-optical antennas allow to confine light on a truly nanometer scale. Indeed, my group recently demonstrated efficient funneling of incident far field to antenna hotspots, i.e. nano-focusing down to 25 nm, and achieved for the first time steering of the angular photon emission of a single molecule. These pioneering results on close encounters between nano-antennas and photon emitters pave the way to a regime of new physical phenomena: super-emission, gradient effects, breakdown of the dipole approximation, near-field spectra, single photon beaming, quantized plasmons and potentially strong coupling. These are exactly the novel effects I plan to explore. Specific objectives are: - Nano-optical control: positioning of single photon emitters at antenna hotspots with < 10 nm accuracy by top-down fabrication, optical forces and chemical recognition. - Super-emission-focusing: boosting of emission to ps Rabi periods and unity quantum efficiency by resonant coupling to the nano-antenna. Photons will be beamed in an antenna dominated angular cone, which in reciprocity acts as the acceptance cone for super-focusing. - Coherent antenna control: by shaping the phase content of broad band fs pulses and tuning the antenna load by optically active materials, I will control nanoscale fields, both in the temporal and spatial domain. - Quantized plasmons: by coupling single photon emitters across a nano-antenna I will explore strong coupling and uncover the quantum nature of plasmons. This research aims for a profound understanding of the fundamental limits of optical control at the nanoscale. The new tuneable photon super-emitters and nano-hot-spots open several new horizons: controlled single photon sources for quantum-information; light harvesting; energy conversion; efficient bio-sensors; optical imaging with 10 nm resolution.",Nano-Optical Antennas for Tuneable Single Photon Super-Emitters,FP7,28 February 2015,01 March 2010,2499600.0 NANOASSAY,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"In this work, I propose the use of a nano/microfluidic system to detect biomarkers relevant to Alzheimer's disease (AD). The use of this system could give earlier and more accurate diagnoses, as well as provide the opportunity for therapeutic interventions and effective disease monitoring. Prior to the diagnosis of dementia and even before the appearance of plaques and tangles, it is suspected that biochemical changes have begun to occur in the brain that eventually lead to AD. Due to the brain being a particularly difficult organ to access, the search for biomarkers has focused primarily on cerebrospinal fluid (CSF) and blood. Because the available sample and biomarker levels are low, clinical tools that can measure candidate biomarkers for reproducible detection are currently insufficient. Here we propose a nanofluidic system with well-defined surface chemistry to greatly improve the sensitivity, selectivity and reproducibility in detection of biomarkers found in CSF. Our device will be fabricated using standard silicon microfabrication procedures to produce highly controlled channels for sample handling and multiplex detection. By working under continuous-flow conditions rather than in batch format, we eliminate variability due to mass transport limitations while allowing for improved standardization. Concentrating the antibodies to a discrete area will increase selectivity and allow amyloid-beta quantitation in spiked serum and real CSF of normal and Alzheimer's donor samples to be achieved. I believe that development of a multiplex diagnostic tool will offer many more people access to better disease diagnosis management and assist in the search for better therapeutics that not only slow disease progression but potentially reverse it.",Development of a multiplex nanofluidic assay for selective detection and monitoring of Alzheimer's disease biomarkers,FP7,25 April 2017,25 April 2014,168794.0 NANOATHERO,National Institute of Health and Medical Research * Institut National de la Santé et de la Recherche Médicale (INSERM),health,"NanoAthero aims to have demonstration of initial clinical feasibility of nanosystems for targeted imaging and treatment of advanced atherosclerotic disease in humans. The nanosystems are assemblies of following components: nanocarrier, targeting, imaging agent/drug. They have proven safety records, and strong preliminary in vitro and in vivo proofs of efficacy are available. Partners have patented and provided evidence of efficacy of carriers and ligands. Over 5 years, NanoAthero will integrate GMP production, the initiation of clinical investigations in high-risk patients, including the preparation of regulatory dossiers, risk and ethical assessments, and the evaluation of the performance of optimized diagnostic and therapeutic compounds. NanoAthero offers a unique opportunity for combining in-depth knowledge of nanocarrier bioengineering and production with state-of the art expertise in imaging and treatment of cardiovascular patients providing a full bench-to-bedside framework within one collaborative consortium of 16 partners from academia, a European association, SMEs and a large pharmaceutical company. NanoAthero gathers together leading chemists, engineers, pharmacists, biologists, toxicologists, clinicians, analysts, ethicists and key-opinion leaders in the field of cardiovascular medicine and early drug development. In NanoAthero, the nanocarriers carrying compounds to visualize thrombus or vulnerable plaques, or to deliver therapeutic agents should be suitable for proof-of-concept in patients. Phase I clinical trials targeting pivotal pathways in atherothrombosis will be performed with nanosystems for diagnosis and treatment of carotid atheroma. NanoAthero aims to propose nanosystems for thrombus imaging, stroke treatment and plaque stabilization in high-risk patients. Molecular imaging and therapeutic treatments in NanoAthero are based on feasible approaches.",Nanomedicine for target-specific imaging and treatment of atherosclerosis: development and initial clinical feasibility,FP7,31 January 2018,01 February 2013,9833348.0 NANOBACTERPHAGESERS,Hacettepe University * Hacettepe Üniversitesi,health,"In this project, we aim to develop nanotechnology-based systems for detection of pathogenic bacteria in several aqueous media mainly in environmental water based on suspension arrays together with a portable custom-designed detection system. The six objectives (six work packages) are as follows: (i) Nanostructured sensors surfaces, in which electron-beam, photo-, soft and dip-pen lithographies will be applied in the fabrication of functionalized low-cost (disposable) SERS substrates, specially designed for simultaneus Raman and Fluorescence enhancement; (ii) nanosorbents and their mixtures as suspension arrays against the target bacteria for capturing units in which firstly magnetically loaded nanoparticles will be produced and labelled/barcoaded with fluorosence dies and/or quantum dots and then bacteriophages, monoclonal antibodies, and/or aptamers will be immobilized onto these nanoparticles as bioligands to recognize and capture the target bacteria specifically; their mixtures will form the suspension arrays; (iii) target bacteria and bacteriophages; the target bacteria (as water pollutants), are Escherichia coli, Enterococcus species and Bacteroides ovatus; bacteriophages which will recognize these bacteria will be selected/produced as bioligands; (iv) aptamers; they will be selected/modified/produced; (v) sensors/array systems; a portable 'Raman Spectrometer/Fluorescence Detector System' will be designed/produced that will be used together with the nanostructured sensors platforms, and finally (vi) validation; the materials and systems developed will be validated. This is a multidisciplinary and technological project and therefore brings together experts from different disciplines both from academia and industry. Basicly, the knowledge that will be developed/ accumulated at lab scale during the project will be transfered to the industrial partners for prototype productions, and then these will bring back to the academical institutions for validation tests.",Design of Novel Portable-Sensors Based on Suspension Arrays Composed of Monoclonal Antibody and Bacteriophage Carrying Magnetically Loaded Nanoparticles and Surface Enhanced Raman Spectroscopy,FP7,31 October 2015,01 November 2011,1625723.0 NANOBAK2,ttz Bremerhaven,health,"The NanoBAK2 project aims to bring together European SMEs from the bakery industry (including both equipment manufactures and bakeries) and one RTD to prove and disseminate the technical and economic viability of a method for low-energy proofing and cooling in SME bakeries. The here proposed concept is built on the outcomes of the successfully finished European research project NanoBAK (Novel climatic chamber with an innovative, energy-saving nano-aerosol humidification system for the manufacture of high quality bakery products). In the frame of this collaborative research project a novel humidification system based on the generation of micro-droplets using ultrasound was developed and tested for the use in bakeries -especially in the proofing process. Compared to conventional humidifiers, where water is heated up, evaporated and cooled down to the required temperatures the NanoBAK system operates at a very low level of energy consumption. The produced technical and scientific results have been excellent and very promising in terms of energy and cost efficiency. Based on these valuable outcomes, it is planned that within NanoBAK2 pre-commercial prototypes will be constructed, implemented and demonstrated at SME bakeries. The NanoBAK technology will be further specified, broadening the application range and overcoming still existing shortcomings. It will be adapted to the specific requirements of small and medium sized SME's in the bakery industry, applied and demonstrated in praxis and developed to direct market applications.",Innovative and energy-efficient proofing/cooling technology based on ultrasonic humidification for high quality bakery products,FP7,31 October 2015,01 November 2013,1745196.0 NANOBARRIER,Stiftelsen for Industriell og Teknisk Forskning (SINTEF),environment,"The overall concept of NanoBarrier is to develop a new nanotechnology platform based on inorganic-organic hybrid polymers, microfibrillated cellulose, nanocapsules with controlled permeability and additive technology and combine this with resource-efficient processing technologies to realize safe and extended shelf-life and multifunctional biopolymer food packaging solutions. These solutions based on CO2 neutral and renewable resources, should work as an enabling technology for innovative companies to stimulate to further consumption growth of fish and seafood and environmental conscious packaging solutions for meat and dairy products; food sectors of major social, economical and health impact in the European region. The project will also bring forward robust biopolymer formulations, compounding expertise and coating approaches to combine nanoparticle technology with biopolymer formulations. Dedicated demonstrators are planned based on resource-efficient processing technologies, such as blow moulding and film blowing. The demonstrators will be multifunctional barrier films for meat packaging, multifunctional barrier bottles for liquid yoghurt and milk and multifunctional barrier jars for crab packaging. NanoBarrier will include sustainable parameters from the demonstrator design step applying ecodesign methodology to minimize the environmental, social and economic impact from the early development step. An LCA will quantify the impact of the foreseen demonstrators and measures are taken to evaluate safety. The objectives of the project will be achieved by implementing the work organized in four technical work packages (in addition to a coordination work package) where each WP are designed to fulfill one- or several of the specific scientific objectives in the project. The project consortium cover the whole value chain from manufacture and competence of nanoparticle technology to end-use supply and include leading organizations and competences throughout Europ",Extended shelf-life biopolymers for sustainable and multifunctional food packaging solutions,FP7,02 May 2018,03 January 2012,7207600.0 NANOBE,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,health,"There is a growing need for effective monitoring of the micro-organisms and bioprocesses used in the sustainable production of fuels, chemicals and pharmaceuticals. The NANOBE -consortium will develop a compact, flexible analysis tool for reaction monitoring applications in the industrial biotechnology industry. The result of the NANOBE –project will be an integrated measurement platform for real-time monitoring of industrial bioprocesses. This versatile platform will enable simultaneous analysis of dozens of analytes, including individual cells, product profiles and intracellular biomarkers. The platform will be composed of multiple 'lab-on-chip ' modules. Together, these modules will measure a broad range of analyte types, including small molecules, proteins, enzymes, metabolites, specific mRNAs and entire cells. The measurement platform will be a significant improvement in terms of automation, analysis time, identification and sensitivity. The analysis platform will permit real-time feedback control of large-scale production processes, screening of production organisms and optimisation of reaction conditions. The tool will improve process productivity, product quality and accelerate development of production organisms for applications in industrial biotechnology. The platform is designed to be flexible so that it can be applied either as a multiplex platform system to monitoring multiple analytes, or as individual device components for analysis of specific compounds. The versatile measurement tool will require only a change in method (e.g. a change of reagents or analysis conditions) to enable the measurement of a new analyte. The NANOBE consortium combines world-class expertise in microfluidics, nano- and microfabrication techniques, photonics, electronics, sensor technologies, and biotechnology. The platform will exploit the scaling laws associated with microfluidic devices to reduce analysis time and sample volume.",Nano- and microtechnology -based analytical devices for online measurements of bioprocesses,FP7,31 March 2012,01 April 2009,2995082.0 NANOBIAS-VILLE2,University of California,information and communications technology,"The aim of this project is addressing some unresolved issues regarding Exchange Bias (EB) phenomenon, together with the search of new materials. The EB connection to the spin and physical the structure, the role of domain formation, and the magnetization reversal mechanisms will be studied. A key tool will be the study of artificially nanostructured materials, in which sample features sizes are comparable to the characteristic lengths governing the magnetic behaviour of materials. This will allow tailoring some magnetic properties, like magnetic anisotropy or the domain morphologies, making possible to determine their role in the EB mechanisms. An arsenal of state-of-the-art experimental techniques will be used, for instance Kerr effect with rare geometries and Polarized Neutron Reflectometry. Among the new magnetic materials, organic thin films will be prospected. EB phenomenon is very poorly understood despite the huge number of applications in which it is already used, for instance in data storage and sensor industries. Moreover, EB may play a crucial role in the development of the emerging and promising spin based electronics or spintronics. Therefore, besides its interest from the fundamental point of view, this project has great interest because of the potential practical applications. The outgoing period will be spent at University of California, San Diego, under the supervision of Prof. I.K. Schuller. There, samples will be fabricated, and also their structural and magnetic characterization will be carried out. In the re-integration period at CEA-Saclay (France), under the supervision of Dr. M Viret, the local magnetic structure will be explored using powerful experimental techniques, as neutron scattering and low-temperature Magnetic Force Microscopy. The present project will strengthen European competitiveness in this fields bringing the expertise of Ivan Schuller's group (UCSD) to the measuring capabilities of the CEA-Saclay.","Exchange Bias in Nanostructured Materials: Spin Structure, Interface Dirsorder, Coupling Mechanisms and New Materials.",FP6,31 August 2008,01 September 2005,0.0 NANOBIO4TRANS,Technical University of Denmark * Danmarks Tekniske Universitet,health,"Organ transplantation is often the only life saving medical approach for several diseases, in spite of many associated problems (lack of organ donors, rejection, life-long heavy medication). The innovative therapeutic approach of the 21th century is focusing on bioartificial organs as an alternative solution.Tissue engineering and stem cell biology have uncovered groundbreaking opportunities for cellular re-programming, i.e., some cell types can be changed into a pluripotent stem cell (PSC) by over-expressing key transcription factors. These induced pluripotent stem cells (iPSC) share two key characteristics with embryonic stem cells (eSC): self-renewal and pluripotency (ability to differentiate to form any cell type in the human body). Crucially, they are generated from adult cells circumventing many ethical concerns associated with using human eSC. The discovery of human iPSC (hiPSC) enables the growth of an almost unlimited supply of a patient´s own cells, potentially conferring the ability to grow and regenerate tissues and organs from 'self', which is expected to resolve organ rejection-related issues. Similarly, recent developments in material science and nanobiotechnology resulted in engineered materials and devices (manipulated and controlled by physical and chemical means), with unique functional or analytical properties. NanoBio4Trans will merge hiPSC-, polymer hybrid scaffolds and biosensor technologies to develop new tools (beyond state-of-the-art) for use in transplantation and biomedical research. The international, trans-sectoral, and multidisciplinary consortium with complementary and leading expertise in material sciences, cell- and molecular biology, sensor technologies, and bioanalytics, aims at developing, optimising and validating a highly vascularised in vivo-like BAL as an extracorporeal bioartificial liver (EBAL), ready to be perfused with human blood plasma, and to be exploited in modern medical technology.",A new nanotechnology-based paradigm for engineering vascularised liver tissue for transplantation,FP7,31 August 2015,01 September 2012,5968093.0 NANOBIOCOM,Fundación Tecnalia Research & Innovation,health,"There are roughly 1 million cases in the USA and 1/2 million in EU of high skeletal defects a year. All of these cases require bone-graft procedures to achieve union, each of which require the surgeon to determine the type of graft material to be use. The toughest challenge appears when the size of the defect is too big and the reconstruction of this defect requires a bone graft capable of supplying similar physical properties and behavior to the bone being substituted. Unfortunately at this moment commercial scaffolds can not satisfy the following issues: * To promote new bone formation in order to reduce the time of bone healing and decrease the vascular insult of the implant to the bone and cause less-stress shielding. * Mechanical properties that match those of human tissue to be regenerated during its new formation. * Regeneration of Large segment of implants. For patients who have lost large segments of bone due to a congenital defect, degenerative diseases, cancer or accident. Based on these basic needs to provide an ideal scaffold, the NANOBIOCOM project aims at establishing the scientific and technological basis for the development new 'intelligent' composite scaffold for bone tissue repair and regeneration with the following issues: + Bioactive behavior capable of activating osteoprogenitor cells and genes and within an in vivo mileu provide the interface to respond to physiological and biological changes, + Mechanical and structural properties similar to a healthy bone. +Size and shape required for reconstructing big skeletal defects Concerning one potential application of the NANOBIOCOM project developments, it can be emphasized that the average age in Europe increases and aged people account for a higher proportion of the population, the nation can expect the $15 billion to $18 billion spent each for the treatment of bone and joint conditions to more than double as well.",INTELLIGENT NANOCOMPOSITE FOR BONE TISSUE REPAIR AND REGENERATION,FP6,30 June 2008,01 May 2005,2017616.0 NANOBIOMAG,Solae Denmark A/S,health,"The scope of the project can be located at the intersection between nano- and biomaterial sciences and magnet technology. The overall objective is to manufacture and then utilise smart magnetic materials in new production processes in order to produce even smarter products for the biomaterials, food and biopharmaceuticals sector. The first step is the manufacture of multifunctional magnetic materials (4M) that will serve as smart tools for new processes to be developed in a second step. The new materials will integrate magnetic properties with additional material properties that are required by their related processes, e.g. nano properties and high specific adsorption surface areas, highly selective affinity interaction properties, site-selective adsorption properties and chemical modification properties, biocompatibility and corrosion-resistance. The new processing technologies to be developed are broadly divided into two research efforts,i.e. those for BIOSEPARATION and BIOSYNTHESIS. The BIOSEPARATIONS effort includes the development of new smart magnetic extraction phases (SMEPs) and the development of novel magnetically enhanced centrifugation processes (MEC). Both efforts target todays major problem in pharmaceutical bioseparations, i.e. that processes are slow, multi-step, low-yield, non-integrated, and thus very costly. The BIOSYNTHESIS effort includes the development of a new magnetic structuring process (NABIS) that allows the defined assembly and crystallisation of macromolecules in a combined magnetic and shear field. The second biosynthesis effort targets the assembly of totally new macromolecule constructs (CUSS) that are not producible by conventional cell factories. The goal is to use smart support materials to modify proteins, e.g. by directed site-selective PEGylation. With the aid of click chemistry this approach may be extended to assemble nano-constructs, e.g. nano-motors or nano-machines.",Magnetic Field Assisted Biomaterials Processing,FP6,29 February 2008,01 March 2005,1998609.0 NANOBIOMAPS,SP Technical Research Institute of Sweden * SP Sveriges Tekniska Forskningsinstitut AB,health,"The objective of this project is to develop new techniques for sub-micrometer-resolved, chemical 3D-mapping of substances in single cells and organised tissues. The techniques will be based on time-of-flight secondary ion mass spectrometry (TOF-SIMS) and laser secondary neutral mass spectrometry (Laser-SNMS), providing simultaneous identification, localization and co-localization of a variety of substances (lipids, peptides, proteins, drugs and metabolites) without the need for pre-selected molecular labelling. The proposed technology constitutes a significant step beyond current methods for chemical analysis of cell and tissue samples, which can only provide either non-local information of the chemical composition or local information of a few pre-selected substances. To meet the minute quantities of sample substance present in the small volumes to be analysed, the detection sensitivities will be considerably improved relative to current conventional technology. By taking advantage of recent progress in (i) sample preparation techniques, (ii) instrumentation, and (iii) data interpretation methods, and by pushing this development further, the required sensitivities and lateral resolutions below 50 nm will be achieved. Methods for 2D mapping at different depth levels, providing 3D chemical analysis, will also be developed. The proposed techniques will lead to breakthrough discoveries and applications in several fields of research and technology, such as fundamental biology, clinical diagnostics, pharmaceutical R&D, nanobiotechnology, and food and environmental impact on health. The project will place Europe in a world leading position in the area of imaging mass spectrometry in biosciences. The present project does not fit into any of the thematic priority areas alone but, instead, cuts across priority areas 1 (life sciences), 3 (NMP) and 5 (food safety)",Imaging mass spectrometry for nanoscale mapping of biological cells and tissues,FP6,24 October 2008,25 January 2005,1899856.0 NANOBIOMAT,Maria Curie-Skłodowska University * Uniwersytet Marii Curie-Skłodowskiej,health,"The primary goal of the Joint Exchange Program (Project) is to create multicomponent materials for biomedical applications and to combine knowledge and experience of the different scientific groups concerning interdisciplinary milestones of the proposal in order to deliver the final product. In the framework of the Project the following materials: porous and nonporous silica oxides, nanostructured carbons, 3D reinforced polymers, metal containing composites and interpenetrating polymer networks, are scheduled to develop biocompatible/bioactive nanostructured materials. According to the programme, the research is focused on: surface modification and interfacial phenomena, structure-property relations, novel biocompatible/bioactive coatings for blood contacting surfaces, (entero)sorbents (for pollutants and (bio)toxins removal), and drug delivery system development. The partner's panel is composed in regards to the Project goals and potential contributions. The consortium includes six partners, three of them are universities from Member States (P1-P3), and the Institute of Chemistry of the Academy of Sciences of Moldova (P4) is representing the Associated States. The Third Country Participants are presented by Partner 5, which comprised of teams from the Russian Academy of Sciences; and Partner 6 is the Chuiko Institute of Surface Chemistry of the National Academy of Sciences of Ukraine. This project will reinforce and strengthen existing bilateral scientific links and transforms them into a larger network which includes all the partners. It will provide momentum for long-term collaboration between the partners. Its results will lay foundation for other actions, aimed at further development and consolidation of the European Research Area and large scale competitive research projects. Additionally, this Project will provide relevant training for the early stage researchers from all teams.",Nanostructured Biocompatible/Bioactive Materials,FP7,31 December 2017,01 January 2014,319200.0 NANOBIOMOFS,ICN2 - Institut Català de Nanociència i Nanotecnologia,health,"The project NanoBioMOFs (Nanoscale Metal–Organic Frameworks for Biomedical Applications) is a step forward to the researcher's work undertaken during his postgraduate studies which comprised synthesising bulk Metal–Organic Frameworks (MOFs) for applications in gas storage, gas and liquid separation and molecular sensing. MOFs can be obtained from the connection of metal centres and organic ligands through the space in such a way that the structures obtained can be extended in one–, two-or three–dimensions. The applicant wishes to extend his knowledge in the same research area but from a completely different viewpoint, synthesising MOFs at the nanoscale regime for applications in drug delivery. To date, nanoparticle systems (polymer, iron or gold nanoparticles) have been used as drug delivery agents. This methodology has attracted much attention as it can improve many of the drawbacks of conventional therapy including high doses, rapid clearance, poor pharmacokinetics and strong side effects. Porous MOFs can be also used as drug delivery carriers due to their tunable host–guest properties and the ability to post–modify their internal surface. Although MOFs are excellent candidates to deliver drugs, they cannot be used in the form of traditional bulk but they have to be miniaturized at the nanometre scale. The aim of this project will be the synthesis of known and novel biocompatible, water–resistant MOFs based on biological ligands at the nanoscale, loading of MOFs with anticancer drugs and check their in vitro safety and therapeutic efficacy for chronic diseases such as cancer. This project allows the applicant to conduct truly interdisciplinary and inter–sectoral research, complementing his expertise in synthetic and materials chemistry in nanotechnology (Catalan Institute of Nanotechnology) and biomedicine (Biotechnology and Biomedicine Institute) at laboratories with long–standing collaboration, unique validation models and and state–of–the–art infrastructure.",Nanoscale Metal–Organic Frameworks for Biomedical Applications,FP7,28 February 2014,01 March 2012,168896.0 NANOBIOPHARMACEUTICS,DECHEMA Gesellschaft für Chemische Technik und Biotechnologie eV,health,"The Integrated Project NanoBioPharmaceutics aims at the development of innovative multidisciplinary approaches for the design, synthesis and evaluation of functionalized nanocarriers and nanoparticle-based microcarriers for the treatment of various diseases based on targeted, controlled delivery of therapeutic peptides and proteins (biopharmaceutics). More specifically, the present IP aims at the following scientific and technological objectives: 1. Design, synthesis and functionalization of novel nanocarriers and nanoparticle-based microcarriers for targeted delivery of P/P drugs via oral, pulmonary and Blood Brain Barrier (BBB) crossing administration routes. 2. Toxicological screening of the nanocarriers and investigation of the release profile of P/P drug under various environmental conditions and the assessment of the biocompatibility and biodegradability of the new formulations. 3. Novel pulmonary P/P carriers with improved delivery features to overcome the administration difficulties and increase efficiency of protein delivery to the deep lung. 4. Oral nanoparticulate P/P carrier systems capable of adhering to the gastrointestinal mucosa and also displaying protective and permeation enhancing properties. 5. Establishment of an in vitro model for the assessment of nanocarriers permeability through the Blood Brain Barrier (BBB). The present IP integrates the scientific activities and complementary skills of researchers coming from 13 EU countries and the state of Israel, in an attempt to ensure breakthrough advances in novel biopharmaceutics delivery systems. The Consortium consists of 12 University departments, 6 research institutes, 6 SMEs and 3 large industries. An efficient management scheme has been established to ensure the fulfillment of the IP?s scientific, technological and exploitation objectives.",Nanoscale Functionalities for Targeted Drug Delivery of Biopharmaceutics,FP6,30 September 2010,01 October 2006,7997720.0 NANOBIOSACCHARIDES,University of Münster * Westfälische Wilhelms-Universität Münster,health,"The NanoBioSaccharides project convenes an interdisciplinary consortium of scientists from academia and industry to develop and exploit nanotechnologies for the generation of knowledge-based, multifunctional, bio-inspired polysaccharides to be used as intelligent, sustainable, environment-friendly and consumer-safe biomaterials. As an example, chitosans generated from shrimp shell and squid pen wastes are an extremely versatile class of biopolymers with superior structural properties and supreme biological activities. However, todays chitosans are ill-defined mixtures of poorly soluble, inhomogeneous polymers, explaining the lack of reproducibility in bio-medical and pharmaceutical applications that have so far prevented their successful commercial use. Other examples of versatile bioactive polysaccharides yet inappropriately exploited include plant pectins and alginates, and human and animal glycosaminoglycans. The core partners of the NanoBioSaccharides project have recently developed a novel concept for the relationship between the physico-chemical properties of chitosans and their biological activities. Based on this 'decoy' concept, we will now use nano- and bio- technologies for the production, modification, and characterisation of third generation bio-inspired polysaccharides. We will develop tailor-made chitosan nanoparticles for drug and gene delivery, and bio-inspired chitosan hydrogels for cell and tissue enigneering. By developing nanotechnologies suitable for polysaccharides, the third and so far neglected and unexploited class of information-bearing biopolymers, the NanoBioSaccharides project will secure the EU a head start in this emerging and promising field of functional bio-inspired materials. The project will integrate the whole product chain from the raw materials to the novel, nano-structured biomaterials to be used in biotechnological applications in medicine, pharmacology, cosmetics, agriculture, and food sciences.'","Nanotechnologies for Bio-inspired polySaccharides: biological decoys designed as knowledge-based, multifunctional biomaterials",FP6,30 September 2008,01 April 2005,2164000.0 NANOBIOTACT,University of Birmingham,health,"The objective is to design and construct an articulated artificial finger with a biomimetic sensor based on an array of NEMS force transducers that will mimic the spatial resolution, sensitivity and dynamics of human tactile neural sensors. This will require the development of the scientific understanding of these mechanoreceptors and the neural coding of the many thousands of action potentials that are discharged during a tactile experience. Experts will be brought together working at the frontiers of knowledge in nanotechnology, psychology, neurology, cognitive science, skin mechanics, robotics, tissue engineering, numerical simulation and information processing. Tactile stimuli will be assessed using physchophysical, neurophysiological and brain imaging techniques. A virtual model of the tactile process will be developed to enable the neurophysiological response of a virtual stimulus to be computed. The information from the psychophysical, neurophysiological, neuroimaging and computer simulation activities will be processed using artificial recurrent neural networks. This will lead to an improved description of the neural coding for taction, such as texture recognition, and lead to design strategies for the MEMS arrays based on advanced optimisation techniques. Biomimetic tactile sensors have many applications, for example, prosthetic limbs with neural interfaced sensing and control, robotics with controlled grip and for haptic exploration, tele-activities (eg remote surgery) and virtual reality training environments. Moreover, an improved understanding of the human tactile system will assist in the treatment of patients with impaired neurological function. The design of new products will be revolutionised, by being able to more effectively exploit rapid virtual prototyping and high throughput screening techniques, for example, in sectors such as personal care, sports, textiles and laundry products and for automobile and do",Nano-engineering biomimetic tactile sensors,FP6,31 May 2010,01 December 2006,2899986.0 NANOBIOTOUCH,University of Birmingham,health,"The main scientific aims are to radically improve understanding of the human mechanotransduction system and tissue engineered nanobiosensors. This will be achieved through systematic integration of new developments from converging scientific areas by involving academic and industrial participants who are experts in cognitive sciences, microneurography, brain imaging, cell biology and mechanics, tissue engineering, skin physics (tribology and mechanics), microengineering, multi-scale multi-physics modelling, information processing, robotics, prosthetics and medical rehabilitation. The project will build on existing discriminative touch research in order to understand affective touch mediated by the human fingerpad. Sensors capable of detecting directional force and temperature will be developed since a combination of these modalities is critical to the affective component of the neurophysiological response evoked in taction. This next generation of sensors will include NEMS arrays and hybrid bio-NEMS systems. They will be integrated into a robotic finger with articulation controlled by neural network information processing that will allow artificial exploration of a surface to be achieved in ways that mimic human haptic behaviour and affective response. The impact of the project will include alleviating the effects of human touch and vision disabilities, improving the quality of life, security printing, brand protection, smart packaging, space exploration and also the evaluation of products such as textiles and skin creams using the instrumented robotic finger. The consortium includes industrial participants who will undertake specific technical exploitation activities in order to maximise the commercial impact of the research.",Nano-resolved multi-scale investigations of human tactile sensations and tissue engineered nanobiosensors,FP7,31 December 2013,01 January 2010,3744590.0 NANOBITS,OFFIS eV,manufacturing,"The atomic force microscope (AFM) has become a standard and wide spread instrument for characterizing nanoscale devices and can be found in most of today's research and development areas. The NanoBits project provides exchangeable and customizable scanning probe tips that can be attached to standard AFM cantilevers offering an unprecedented freedom in adapting the shape and size of the tips to the surface topology of the specific application. NanoBits themselves are 2-4 μm long and 120-150 nm thin flakes of heterogeneous materials fabricated in different approaches. These novel tips will allow for characterizing three dimensional high-aspect ratio and sidewall structures of critical dimensions such as nanooptical photonic components and semiconductor architectures which is a bottle-neck in reaching more efficient manufacturing techniques. It is thus an enabling approach for almost all future nanoscale applications. A miniaturized robotic microsystem combining innovative nanosensors and actuators will be used to explore new strategies of micro-nano-integration in order to realize a quick exchange of NanoBits. For the fabrication of the NanoBits, two different techniques are proposed. On the one hand, a standard silicon processing technique enables batch fabrication of various NanoBits designs defined by electron beam lithography. On the other hand, focused ion beam milling can be used to structure a blank of heterogeneous materials, the socalled nembranes. Novel scanning modes in atomic force microscopy will be developed to take full advantage of the different NanoBits geometries and to realize AFM imaging of critical dimension structures. The innovative nanoimaging capabilities will be applied to characterize and develop novel nanooptical photonic structures in the wavelength or even sub-wavelength range and TERS applications in the nanomaterial and biomedical sector. Especially the involved SMEs will exploit and disseminate the results to potential users to realize a more efficient micro-and nanomanufacturing.",Exchangeable and Customizable Scanning Probe Tips,FP7,31 August 2013,01 September 2010,2499998.0 NANOBOND,Devan Chemicals NV,health,"One key area of the European textile industry is the technical development of products and processes for reducing contamination and the removal of stains of all kinds from manufactured articles, including textiles. To a large part this is necessary for keeping up performance and function, often for health reasons, although sometimes this is for purely aesthetic effects. Thus, easy-to-clean, soil release and antimicrobial properties are linked aspects that are of great importance such: health and avoidance of cross-contamination in medical textiles; improvement in comfort and freshness in consumer apparel; reduction of spoilage or wastage during storage and transport; increase useful lifetime of articles. These benefits further contribute to the overall goal of sustainable product development, to save energy and to protect our water resources. As alternative to commonly used biocidal chemicals, we propose a new surface modification concept that can control surface microbial contamination, particularly the development of bacterial colonies and biofilms. Taking into account the needs of customers and environmental protection, the NanoBond Project aims to develop a new antimicrobial 'soft nanotechnology' that comprises: •Adaptability to a wide range of consumer and industrial applications. •A responsive technology that adapts to the particular requirement for anti-microbial effect without 'swamping' the environment with the un-restrained release of chemical antimicrobial agents, which is typical of other antimicrobial technologies. •Highly-tailored solutions by altering the characteristics of the polymeric nano-film. The NanoBond Project will exploit the 'soft nanotechnology' to create nano-structured and functional surfaces that can impart multiple beneficial properties, or can act as a scaffold for the further incorporation of other performance finishes. •Durability and effectiveness for the life of the goods. •Easy application and low application levels.",Integration of emerging soft nanotechnology into the functionalisation of textiles,FP7,31 August 2012,01 September 2009,1678871.0 NANOBRAIN,IMEP-LAHC Laboratory,information and communications technology,"These last fifty years have seen Von Neumann computing architectures boom. Nevertheless, even the most powerful digital computers cannot rapidly solve apparently simple problems such as image interpretation. However, because its structure is",On-chip memristive artificial nano-synapses and neural networks,FP7,10 July 2017,11 January 2010,0.0 NANOBRIDGES,University of Gdansk * Uniwersytet Gdański,environment,"The project is aimed at creating a worldwide network of research partnerships, including various types of research organizations from EU and third countries, with different profiles (computational and empirical risk assessors), focused on the development of new tools for computational risk assessment of engineered nanoparticles (NPs). The mobility plan, supported by the electronic communication tools will create a platform for sharing knowledge and overcoming the fragmentation of scientific efforts in this novel and high priority research field. This is important, because extensively developing nanotechnology might create a significant risk for humans and the environment.",Building bridges between specialists on computational and empirical risk assessment of engineered nanomaterials,FP7,12 July 2016,01 January 2012,0.0 NANOC,Polytechnic University of Valencia * Universitat Politècnica de València,information and communications technology,"The NaNoC project aims at developing an innovative design platform for future Network-on-Chip (NoC) based multi-core systems. This NaNoC design platform intends to master the design complexity of advanced microelectronic systems by enabling strict component oriented architectural design. A compositional approach to NoC design in future multi-core chips is out of the reach of current design methods and tools due to new design constraints. Requirements for co-design with high-level platform management frameworks facilitates a need for enhanced dynamism and flexibility in NoC composition (e.g., virtualization, power management, thermal management, application management). On the other hand, a higher degree of uncertainty originating from nanoscale IC fabrication technologies raises the need to build reliable systems out of unreliable components.",Nanoscale Silicon-Aware Network-on-Chip Design Platform,FP7,12 July 2014,01 January 2010,0.0 NANOCAGE,King's College London,health,"Inorganic nanomaterials have attracted extensive attention as a result of their potential for a multitude of applications including those related to electronics and catalysis, and as part of sensors in medical diagnosis. Previously, we have described a new technique to generate gold nanoparticles inside the cavity of a ferritin cage protein by first forming a small nanocluster and using it as a seed for particle formation. Unlike previous techniques, this method does not require modification of the protein (e. g. engineering cysteine residues inside the cavity) and therefore has the potential to be used with any nanocage protein. This cage protein universality is a powerful aspect of our technology as the use of various cage proteins could provide synthetic vessels of different sizes and shapes, resulting in nanoparticles with different, and rationally defined, morphologies. Our method provides a second advantage in that the initial nanocluster could be used to seed other metals, resulting in protein-encapsulated, core-shell, dual-metal, nanoparticles. (These two advantages are exploited in Objective 1). Third, our method, by providing presumed universal flexible access to protein cages with different symmetries, sizes, and 'handle' attachment sites, could provide, using the power and precision of molecular biology and advances in protein engineering, the opportunity to control the supra-assembly of the nanoparticles, and thus bridge the nano- and micro-scale through a 'bottom-up' approach. (This third advantage is exploited in Objective 2) This extremely multi-disciplinary proposal, which marries molecular biology, protein engineering, and nanomaterials, aims to explore and expand upon the flexibility and advantages of our previous work by focusing on these three advantages to generate new hybrid materials.",The Development of Protein Cage-Based Inorganic Nano-Materials (resubmission),FP7,31 July 2017,01 August 2013,100000.0 NANOCAL,IMEP-LAHC Laboratory,information and communications technology,"The continuous reduction of particle size in materials science has opened up new possibilities of producing materials at small length scales. The potential applications derived from the new properties of these materials span along multiple disciplines. In particular, magnetism at the nanoscale is the basis for new spintronic physics and devices. Whereas the production of nanoparticles, nanoclusters or multilayers of magnetic materials is widely spread, the understanding of phase transitions, specifically magnetic interactions (exchange bias, exchange spring) or magnetization reversal at the nanoscale remain a scientific challenge. In this project we propose to study nanomagnetic materials through their thermal properties or signatures in order to extract specific properties which cannot be deduced from regular magnetic characterization (magnetization, susceptibility measurement) more commonly encountered in the magnetism community. Calorimetry is an important tool to obtain information about magnetic phase transitions in bulk materials. Recently, highly sensitive sensors have been developed allowing measurements with a high resolution on ng samples. The development of suitable thermal sensor relies on a common principle, the use of a suspended membrane to isolate the core of the device from the heat sink. At low temperatures the calorimetric method giving the best results in terms of sensitivity is ac calorimetry. The group of Bourgeois has recently reach unprecedented sensitivities in the attojoule range. In the present project we will take benefit of this achievement to study the thermodynamic signatures in magnetic nanoparticles and in bilayer coupled films through magnetic exchange. The present approach will provide new insights in the understanding of the appearance of phase transitions at the nanometer scale (not yet understood) or in the magnetization reversal mechanism in exchange bias bilayer: the two major goals of our project.",Magnetic mechanisms at the nanoscale studied by themal probe: nanocaloriometry and heat released.,FP7,08 July 2012,09 January 2008,162509.69 NANOCAP,IVAM UvA BV * Interfaculty Environmental Science Department (IVAM) of the University of Amsterdam,health,"Nanotechnology is a major growth area in research and industry. Applications of nanotechnology include advanced materials, textiles, prosthetic implants, food and drugs. Nanosizing products has many benefits. However, there is also a serious debate about the potential hazards of nano-particles (< 100 nm), when introduced into the environment and workplace. The NANOCAP CA is set up to deepen the understanding of environmental, occupational health and safety risks and ethical aspects of nanotechnology by organising a structured discussion between NGOs, academic researchers and other stakeholders. This CA will enable environmental NGOs and trade unions to participate in a debate on nanotechnology at European level. It will improve their understanding of this new technological field, and it will give them the opportunity to formulate their positions within their actual policy context supported by scientific input, to inform their members and the general public and to discuss the issues. NANOCAP will develop recommendations to enable public authorities to address the health, safety and environmental risk issues related to the rapid introduction of nanotechnology into society. At the same time it is the goal of this CA to give industry the tools to introduce a 'responsible nanotechnology', i.e. to stimulate industrial and academic performers to focus on source reduction regarding nano-particles and to make risk assessment an important dimension in their work. NANOCAP is a consortium of 5 environmental NGOs, 5 trade unions and 5 universities that will hold a series of focused working conferences, in which a structured enhancement of stakeholder capacities is planned. The universities take care of scientific input for the conferences. NGOs and trade unions will bring in their preliminary positions after discussions with their members. A portfolio on ethical issues and a position concerning 'responsible nanotechnology' will be prepared and actively disseminated.",Nanotechnology Capacity Building NGOs,FP6,31 August 2009,01 September 2006,1306180.0 NANOCAPSULE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The idea of the proposed project is to employ hollow polyelectrolyte capsules as spatially-confined microreactors for synthesis of composite inorganic nanomaterials. Recently introduced, these capsules are made by layer-by-layer adsorption of oppositely charged polyelectrolytes on the surface of template nanoparticles with sequential removal of the template core. Polyelectrolyte capsules can act as excellent microreactors for carrying out physico-chemical processes (nanoparticle precipitation, biomineralization, biomimetic synthesis, photocatalytic synthesis, etc.) in their spatially restricted volume. The possibility of varying shell components and capsule size gives a considerable diversity in synthetic approaches and initial reagents while selective and controllable permeability of the capsule wall, which is a key factor for performing chemical reactions exclusively inside the capsule volume, allows to control diffusion of the reagents and reaction kinetics. The main project objectives are:1) to understand mechanism of physico-chemical reactions in restricted capsule volume and to figure out parameters of crucial influence (shell, volume composition; capsule size; etc.) on the reaction kinetics and properties of resulting nanomaterials;2) to fabricate new composite nanomaterials and to study their properties in comparison with properties of analogous nanomaterials obtained in bulky water solution;3) to realize enzyme-containing polyelectrolyte capsules as semipermeable enzyme-driven nanoreactors for biomimetic synthesis of inorganic materials.Proposed project is a multidisciplinary one and its results can be of interest for scientists from material science, biotechnology, nanotechnology, life science, catalysis, medicine, and environmental chemistry. The proposed project contributes to the 'Nano-technologies and nano-sciences, knowledge-based multifunctional materials, new production processes and devices' thematic priority of 6th European Programme.",Nanoengineered Chemical Synthesis Inside Restricted Volume of Nano- and Microsized Polyelectrolyte Capsules,FP6,30 April 2007,01 May 2005,155363.0 NANOCARD,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Cell therapy and tissue engineering are emerging as novel therapeutic paradigms for myocardial repair. The rationale behind the cell replacement approach is based on the assumption that an increase in the number of functional cardiomyocytes within the diseased area may improve the mechanical properties of this compromised region. A common strategy attempts to initially combine, ex-vivo, cells with polymeric scaffolds to generate a construct, followed by in-vivo engraftment onto the heart muscle. Despite first encouraging results, the clinical utility of these approaches is hampered by the paucity of cell sources for human cardiomyocytes and by the limited direct functional integration of grafted cells and high degree of donor cell death following cell grafting in host myocardial tissue. NanoCARD will create a conceptually new type of biomimetic nanoscopically designed scaffold able to generate cardiac tissue replacement for the myocardium. Within our project we will design novel cellular environments with broad but precisely-controlled diversity in chemical composition, physical properties, and geometrical spacing of individual peptides on the nanometre scale. The capability of these environments to regulate cell response will be explored by high throughput approaches using a new chip technology developed within the project. An additional unique concept for controlling the function of cardiac cells is given by applying periodic mechanical strain in the range of heart frequency during the tissue engineering process. The knowledge gained within NanoCARD will be translated into the design and production of a novel biocompatible nanostructured device (therapeutic surface) with a desired bioactivity inducing specific behaviour of endothelial cells and cardiomyocytes to revolutionise treatment of myocardial defects. The inclusion of relevant companies in the consortium assures the identification of opportunities for the intended product developments.",Nanopatterned scaffolds for active myocardial implants,FP7,31 December 2013,01 January 2010,3806600.0 NANOCAT,Abo Akademi University * Åbo Akademi,health,"Production of better than existing pharmaceuticals, healthy food ingredients, perfumes, other fine chemicals, which are of immense importance for improving quality of life, is often limited by low selectivity in their synthesis over heterogeneous catalysts. Selectivity of these catalysts, bearing metals of nanoparticle size, could be enhanced by carefully adjusting the size and environment of metal nanoparticles. The project is aimed to study the influence of metal nanoparticle size and its environment on catalytic behaviour in some representative reactions of industrial importance and, finally, to establish the fundamental knowledge on atomic/molecular level relating the nanocatalyst synthesis and behaviour. The model reactions represent selective oxidation, chemo- and enantioselective hydrogenations as well as catalytic isomerisation reactions, where the use of conventional supported catalysts yields to too low selectivities of the desired products. By changing the size, shape and local environment of the nanostructures, their functionality may be controlled. To achieve the main goal, following tasks will be performed: i) development and physico-chemical characterisation of Ru, Pt, Pt-Au and Pd nanoparticles of 1-10 nm diameter incorporated in inorganic and organic functionalised and non-functionalised micro-mesoporous matrices, polymer or carbon nanofibers, ii) catalyst testing in hydrogenation and oxidation , yielding the intermediates used for production of biologically active compounds, healthy food incredients and parfumes, iii) development of reaction mechanisms by combination of diffusion and kinetic modeling together with time dependent Monte Carlo - quantum chemical calculations. The obtained results will allow finding correlations between the nanoparticle size-shape-environment and catalytic behavior. Prevention of metal leaching by incorporating metal nanoparticles in matrices allowing catalyst reuse will be studied.",Tailored nanosized metal catalysts for improving activity and selectivity via engineering of their structure and local environment,FP6,31 January 2008,01 February 2005,2054699.0 NANOCATE,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,energy,"The multidisciplinary consortium of the NanoCaTe project will develop a more efficient thermoelectric- and storage material based on nanocarbon (e.g. graphene and CNT) to reclaim waste heat by thermoelectric generators and to storage the energy in super capacitors or secondary batteries for manifold applications like pulsed sensors or mobile electronic devices. The integration of the developed materials into harvester and storage devices is a further step to characterize the performance of the innovative materials. Finally, a demonstrator consisting of harvester, storage and energy management represents a self-sustaining, universally usable, and maintenance-free power supply. The project will substantially strengthen the position of Europe in the field of thermoelectric and storage materials by developing devices with increased lifetime produced by cost-efficient technologies and therefore contributing to a further promotion of cleaner energy technologies.",Nano-carbons for versatile power supply modules,FP7,30 September 2017,01 October 2013,3994210.0 NANOCELLUCOMP,Institute of Nanotechnology,energy,"The overall aim of the NanoCelluComp project is to develop a technology to utilise the high mechanical performance of cellulose nanofibres, obtained from food processing waste streams, combined with bioderived matrix materials, for the manufacture of high performance composite materials that will replace glass and carbon fibre reinforced plastics in many applications including transportation, wind turbines, biomedical, sport and consumer goods. The technology will include two key stages: 1) liberation of cellulose nanofibres from vegetable food waste and combining the nanofibres with polysaccharides in a single process free of organic solvents to form a 100% bio-composite comprising up to 75 wt% of cellulose nanofibres and 2) orientation of cellulose nanofibres and compaunding the composite in a form easily usable for established technologies, e.g. in the form of bio-prepregs or as composite fibres suitable for bonding with a bioresin. The development of the technology components will be based on the principals of green chemistry and green engineering and aimed to achieve the Technology Readiness Level 6 (a prototype demonstration in a relevant environment) by the end of the project. The project directly addresses all key objectives of the NMP.2010.1.2.1-2 topic. In particular, the new process and materials will significantly contribute to • increase in the sustainability of high performance composites by using vegetable food processing waste; • reduction on the demand of scarce or non-environmentally friendly raw materials by replacing synthetic materials with bioderived nanocellulose and polysaccharides; • elimination of use of volatile solvents in polymer composite production processes by using only water as solvent; • reduction in the energy consumption in composite manufacture. The substitution potential of the new materials shall be investigated in a systematic way during the project.",The development of very high performance bioderived composite materials of cellulose nanofibres and polysaccharides.,FP7,31 March 2014,01 March 2011,2411183.0 NANOCEM,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),construction,"Cements and concrete are essential components of the construction environment and, relative to other permanent materials,are environmentally appropriate for the future. Yet improvements can and must be made: the industry has lagged behindothers in developing a materials-oriented approach. This proposal will close the gap by developing the relevant base ofenabling science and providing pan-European training for the 21st century. In the preparation of this proposal five self-fundedforums have been organised . These involved the leading academics and industries of Europe. The RTN project will addressthe need to undertake high quality precompetitive research, to train a new generation of researchers equipped forinterdisciplinary methodologies and prepare the industry to embrace change. Additionally it was accepted that the industryoperates internationally and that the scattered academic expertise in Europe should work in a more coordinated manner thanhitherto in response to these challenges.A MC RTN represents the best way to achieve our goals with an intersectorial grouping of 6 universities, 4 Institutes and 7Industrial parners, including a SME and an Industrial Association. The research programme is oriented around 3 themesadressing short, medium and long term needs of the field: (1-deterioration of cement matrices 2- Physical and mechanicalverification of performance; 3- new and nnovative cement based materials) to lay the basis for future technological andscientific breakthroughs. In each theme the aim is to demonstrate the value of a fundamental approach. The trainingprogramme of NANOCEM is 75% research-oriented to provide to the network fellows a muldisciplinary approach towardscementitious materials. In addition, social science, environmental, industrial and normalisation issues will be provided throughone-week courses each 6 months to enable the fellows to face the new scientific and technological challenges.",Fundamental understanding of cementitious materials for improved chemical physical and aesthetic performance,FP6,30 April 2011,01 March 2006,3021014.0 NANOCERAM,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"The aim of the project is to develop the technology of processing ofnanosized ceramic powders including the adoptions of shaping method for prototypes as well as for small and large series. The project is focused on applications ofY -stabilized ZrO2 and Si3N4 for wood cutting tools as well as for parts of medicine technique and micro systems, micro reactors and sensors. The plasma chemical technology for powder manufacturing and new technologies of surface modifications of the powders will be a breakthrough for the use of ceramic nanopowders in connection with the shaping methods gel casting, inj ection moulding and pressing. The sintering methods must become developed for nanopowders to get dense materials with nanosized microstructure. Wear resistant cutting tools and instruments, gears and bearings with low friction coefficient shall become key components for new products. The involvement of SME's guaranties the flexibility to enter into the aimed market. Other applications shall follow.",Cutting tools and miniaturised parts with complex geometry based on nano powders (NANOCERAM),FP6,31 July 2006,01 August 2004,451945.0 NANOCF,Leibniz Institute of Polymer Research Dresden * Leibniz-Institut für Polymerforschung Dresden,photonics,"Low-dimensional carbon structures such as graphene and carbon nanotubes have raised tremendous interest in recent years both from fundamental and technological perspectives. However, the tunability of the density of electronic states of graphene and carbon nanotubes remains a limiting factor for their implementation in modern nanotechnology. It has been recently shown that the energy bandgap of graphene-based materials can be tailored via chemical modification of the graphene surface, e.g. by fluorination. We focus our efforts on tuning the chemical and physical properties of nanocarbon materials using different fluorination techniques and varying the degree of fluorination. A multidisciplinary approach will be applied ranging from fundamental research in chemistry and physics to studying the materials properties for application in electronics, photonics, and biomedicine. It is anticipated that the final outcome of this project will be a novel nanocarbon-based material with specific advanced properties.",Tuning the properties of NanoCarbon with Fluorination,FP7,30 September 2017,01 October 2013,207000.0 NANOCHARM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Ellipsometry and polarimetry have enormous capabilities for characterization of multifunctional materials, devices, processing and phenomena at the nanoscale, with consideration of the nanostructure-properties-functionality relationship, which can be addressed non-destructively, non-invasively, in non-contact, in-line and in real-time without any specific condition requirements for measurements and without any sort of environmental impact. This Coordination action is aimed at expressing, assessing and spreading capability of ellipsometry/polarimetry in serving nanomaterial scientists, producers and end-users to address complexity of a large variety of multifunctional nanostructures, hybrid systems, interface behaviours, surface-related phenomena, molecular self-assembling: for all those systems, ellipsometry/polarimetry is beyond just dimension at the nanoscale yielding information on compositional, optical, electrical, magnetic characteristics associated to the specific nanostructure. This CA identify European expertise and establish a platform for (1) coordination of research on ellipsometry for a large variety of nanomaterials, devices and technologies (2) dissemination and development of actions to allow nanomaterials scientists, students, SMEs and end-users approaching and exploiting ellipsometry and polarimetry for designing nanomaterials and nanodevices with unexplored functionalities and for controlling/implementing related production technologies. Advantages that this CA include improvement of knowledge of chemical and physical properties of nanomaterials, new controlled procedures of production, and more sustainable products. The technological impact is huge involving the major production areas and industries of a developed economy such as health-(medicine, biotechnology), environment-(hazardous gas sensing-monitoring), energetics-(photovoltaics), components-(semiconductor, coating industries), which all produce and use multifunctional nanostructure",MULTIFUNCTIONAL NANOMATERIALS CHARACTERISATION EXPLOITING ELLIPSOMETRY and POLARIMETRY,FP7,31 December 2010,01 January 2008,1200000.0 NANOCHEMIMAGE,University of Bristol,manufacturing,"The science of nanoscale structures and processes is currently an area of enormous activity, attracting great cross-disciplinary interest from researchers worldwide. This rapidly developing field requires novel tools and techniques for nanoscale analysis. The atomic force microscope (AFM) and scanning near-field optical microscope (SNOM), for example, have developed in response to this requirement. Recent work has demonstrated the potential of SNOM techniques to enable nanoscale infrared (IR) spectroscopy. Such a capability would be of immense value in understanding chemical processes at the nanoscale, such as those driving the self-assembly of materials or modifying protein conformation. Progress towards true nanoscale IR spectroscopy is, however, badly hampered by the lack of suitable widely-tuneable IR laser sources. The proposed reintegration grant will provide valuable supplementary support to five-year fellowship project, recently awarded to the researcher. This project addresses the development of suitable tuneable sources, based on nonlinear optical frequency conversion techniques, and their application to IR SNOM for the first time, thus enabling effective spectroscopic analysis of nanoscale objects. Collaborative studies of nanostructured materials and biomaterials will both validate the techniques developed and address important issues in the study of these systems. It is anticipated that the final outcome of this project will be a novel analytical tool of great value to nanoscale research in chemistry, physics and the materials and life sciences.",Nanoscale chemical imaging: Tools and techniques for localised infrared spectroscopy of nanostructured polymers and biomaterials.,FP7,02 April 2013,03 January 2008,45000.0 NANOCHIRALITY,University of Barcelona * Universitat de Barcelona,photonics,"We propose the study the interaction of electromagnetic field with complex chiral media media at optical frequencies by means of Mueller matrix polarimetry. The project spreads on two main areas of study: natural and artifical chiral anisotropic media. To start with, we will study the effect of chiral polarizations and chiral transfer in natural supramolecular chemical systems. When it comes to artiï¬cial materials, we will work on the characterization of the so-called metamaterials, with totally new effective dielectric properties from nanometer-sized ''photonic atoms''. The main optical property where we will focus our attention is the optical activity displayed by some photonic metamaterials. To accomplish these studies we plan to develop new measurement technologies based on Mueller matrix polarimetry.",Polarimetric characterization of natural and artificial chiral anisotropic media,FP7,31 January 2016,01 February 2014,166336.0 NANOCI,University of Bern * Universität Bern,health,"Over 60 million of citizens in the EU suffer from hearing loss with its associated restrictions. In severe cases, hearing can only be restored by surgically implanting a neuroprosthesis called cochlear implant, which directly stimulates the auditory nerve. The bottleneck for optimal stimulation is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through (i) low frequency resolution, hence poor sound quality and (ii), strong signal amplification, hence high energy consumption responsible for significant battery costs and for impeding the development of fully implantable systems. Recent findings indicate that auditory nerve fibres can grow under neurotrophin stimulation towards the electrodes, which opens the door to address all issues simultaneously. NANOCI aims at developing a neuroprosthesis with a gapless interface to auditory nerve fibres. The neurites will be attracted and guided by an innovative, nanostructured gel matrix containing diffusible and surface-bound neurotrophic compounds towards the functionalized, neurotrophic electrode array surface. The long-lasting operation without interface degradation, reduced biofouling and improved conductivity will be achieved by nanostructuring the array surface using (i) various functional nanomaterials, including carbon nanotubes, combined with (ii) structuration methodologies such as ion implantation and sacrificial nanoparticle embedding in parylene, SOLID (solid on liquid deposition) encapsulation, and sonochemistry. Components will be validated using appropriate bioassays including human auditory neurons in vitro. In parallel, software models will be developed to exploit the bidirectional, gapless interface. Fusing all developments, an animal-grade, pilot nanoCI-device is manufactured and tested in vivo. This will allow to assess the feasibility of a future, cost-efficient, and fully implantable neuroprosthesis with substantially increased sound quality.",Nanotechnology based cochlear implant with gapless interface to auditory neurons,FP7,31 August 2015,01 September 2012,3599853.0 NANOCIS,Polytechnic University of Valencia * Universitat Politècnica de València,energy,"The main objective of NanoCIS is the establishment of a cooperative partnership between research organizations through a joint program of exchange of researchers for developing a new generation of photovoltaic (PV) solar cells. This new generation of PV solar cells will be based in approaches involving the use of new materials with high conversion efficiencies and low-cost fabrication techniques. The broad aim is the theoretical and experimental design, synthesis and characterization of new advanced materials, based on chalcopyrites absorbers, allowing the manufacture of an intermediate band solar cell. New concepts such as Intermediate band and luminescent materials for further development of CIGS solar cells are going to be investigated. This new class of materials has been predicted theoretically as potential candidates for providing very high efficiency (63%) in solar energy conversion. According to present knowledge, this compounds based on chalcogenide-type semiconductors are quite novel as general materials, especially in their application to solar energy. Electrodeposition (ED) is the technique chosen for developing such approaches. ED is essentially a non-vacuum approach to fabricate high quality thin-film materials for PV modules that could lower the manufacturing costs by over 50% and increase the PV module efficiencies. The ED technique offers the most attractive range of benefits leading to the low cost fabrication of PV cells, such as high rate of deposition, high resolution, high shape fidelity, self purification, scalability and good compatibility with existing processes. ED adds another cost effective step in low-cost solar cell because the transparent conducting oxide layers (TCO) can be deposited by the same method. The use of inline processing through an exclusively non-vacuum technique will further contribute to the improvement of device performance.",Development of a new generation of CIGS-based solar cells,FP7,30 April 2015,01 May 2011,430500.0 NANOCLASSIFIER,Attana AB,health,"Nanomedicine and Nanosafety rely on the same fundamental interactions between the nanoparticle interface and the biological milieu surrounding it, and it is this 'corona' of proteins and other biomolecules that form at the bio-nanointerface that determines the fate and behaviour of nanomaterials. Understanding, classifying and predicting nanoparticle coronas from their physicochemical properties offers a novel approach to screening for toxicity at early stages of product development and for regulatory purposes. This biomolecule corona also explains why many nanoparticle targeting strategies, that seem promising when tested under non-physiological conditions, fail when tested in vivo, where multiple competitive interactions occur, and where non-specific binding in many cases blocks the targeting functionality of the nanoparticles, rendering them inactive. However, despite the rapid increase of our understanding of the issues, methods by which to characterise the functioning bio-nanointerface in biologically relevant environments remain a challenge, and are time consuming and expensive. The partners in the NanoClassifier IAPP project are at the forefront of their respective areas and are pioneering new methodologies for study of complex questions in biologically relevant milieu and represent an optimal partnership to address this challenge. Together, NUID UCD and Attana AB will develop a cost effective, high throughput screening platform for characterisation of the bionanointerface and its cell-binding partners, to address a range of important questions currently hampering the implementation of nanotechnologies, both in medicine and generally in consumer products. The inter-sectoral nature of the project is critical to its success, as Attana AB bring their platform for kinetic characterization of protein interactions on intact cells in real time, and NUID UCD bring extensive understanding of the bionanointerface and its practical and regulatory significance.",NanoClassifier - QCM for rapid label-free Bionano interface evaluation and screening of effectiveness of nano-targeting strategies for therapeutics.,FP7,31 December 2017,01 January 2014,933420.0 NANOCLEAN,"MAIER, S.Coop.",health,"Progress in nanotechnology benefits achieving new functions and features for numerous new products and applications through the knowledge-based tailored properties. However, despite these special features, there are many challenges to transfer real applications into our daily life. NANOCLEAN project seeks to demonstrate the up-scaling of tailor-made nanostructured based self-cleaning feature on plastic components through cross disciplinary approach. In particular, the proposed technology is based on stable and durable so-called lotus-effect from both chemical and physical methods such as nano/micromachining - templation technologies and nanomodified materials. Therefore, the project will evaluate and assess the large scale production of advanced nanostructured plastic components for automotive sector, with controlled wettability properties, by combining the application of specific nano-microstructured surface through enhanced energy femtosecond laser pulse, specialty formulated and modified polymers and industrially implanted injection moulding technology. Furthermore, due to versatility of proposed process, an effort will additionally be carry out to promote this technology of controlling the wetting properties of large volume market plastic products for application to very many different systems where liquid and solid phase are in contact (consumer products, medical products, microfluidic, electric/electronic appliances…...).",Optimisation and upscaling of self-cleaning surfaces for automotive sector by combining tailored nanostructured machined injection tools and functional thermoplastic nanocompounds,FP7,30 September 2012,01 October 2009,2906692.0 NANOCLUSTERPROTEIN,University of South Paris * Université Paris-Sud,health,"The proposal concerns the study of interactions between polyoxometalates and biomolecular systems, including proteins and carbohydrates. Polyoxometalates (POMs) are early transition metal-oxygen anionic molecular nanoclusters. In addition of numerous other positive properties, some POMs exhibit anti-bacterial, anti-viral, anti-tumor, anti cancer activities or are observed to reduce the symptoms of diabetis. However, the detailed mechanisms of these phenomena at the molecular level remain elusive. This project is aimed at shedding some light on the matter, in order to open the way for a rational application of POMs in the medical domain. The proposal is highly multidisciplinary and involves collaboration between a number of research groups. For example, collaboration with groups expert in the synthesis of new POMs will be useful to enlarge the impressive number and variety of nanoclusters already available in the host group. The characterisation of the nanostructures will involve detailed X-ray analysis of the superstructures and various electron microscopic techniques. Selection, purification and/or modification of proteins and the synthesis of rationally designed carbohydrates necessitate work with biochemists and scientists familiar with glycolipids. The evaluation of the biological activity of POMs will also be studied in collaboration. Nanoscience, in which POMs participate, is believed to be an area of research most likely to produce breakthroughs and European Commission has marked this field as one of its high priority research areas, taking into account the high potential for innovative applications. Health is another area of constant concern. The results of the present research project are expected to impact positively two issues among currently important topics. For intellectual properties, the guidelines of the European Commission will be strictly adhered to. A detailed indicative work plan is proposed in Europe and back to China.",Multidisciplinary approach to polyoxometalate-protein interactions: mechanisms and biological applications,FP6,17 October 2008,18 October 2006,159353.04 NANOCLUSTERPROTEIN,CAS- INSTITUTE OF CHEMISTRY (ICCAS),health,"The proposal concerns the study of interactions between polyoxometalates and biomelecular systems, including proteins and carbohydrates. Polyoxometalates (POMs) are early transition metal-oxygen anionic molecular nanoclusters. In addition of numerous other positive properties, some POMs exhibit anti-bacterial, anti-viral, anti-tumor, anti cancer activities or are observed to reduce the symptoms of diabetis. However, the detailed mechanisms of these phenomena at the molecular level remain elusive. This project is aimed at shedding some light on the matter, in order to open the way for a rational application of POMs in the medical domain. The proposal is highly multidisciplinary and involves collaboration between a number of research groups. For example, collaboration with groups expert in the synthesis of new POMs will be useful to enlarge the impressive number and variety of nanoclusters already available in the host group. The characterisation of the nanostructures will involve detailed X-ray analysis of the superstructures and various electron microscopic techniques. Selection, purification and/or modification of proteins and the synthesis of rationally designed carbohydrates necessitate work with biochemists and scientists familiar with glycolipids. The evaluation of the biological activity of POMs will also be studied in collaboration. Nanoscience, in which POMs participate, is believed to be an area of research most likely to produce breakthroughs and European Commission has marked this field as one of its high priority research areas, taking into account the high potential for innovative applications. Health is another area of constant concern. The results of the present research project are expected to impact positively two issues among currently important topics. For intellectual properties, the guidelines of the European Commission will be strictly adhered to. A detailed indicative work plan is proposed in Europe and back to China.",Multidisciplinary approach to polyoxometalate-protein interactions: mechanisms and biological applications,FP6,17 October 2009,18 October 2008,31000.0 NANOCMM,"Unimetrik, SA",transport,"Metrology is essential at any stage of development and production. For conventional industries (e.g. automotive), classical coordinate measuring machines (CMMs) are flexible enough that they can be delivered off the shelf for most development and process control problems. In this project, the ?CMM approach? shall be made applicable to micro- and nano-structures too. For this a Nano CMM shall be developed which is capable to measure real 3D (sub-) micrometre structures, including the today not measurable micrometric holes, undercuts, and gaps, all with 50-100 nm accuracy. Pursuing this, a number of technologies are still lacking: probes to localise points on objects with this accuracy; reference objects to calibrate Nano-CMMs; calibration facilities for nano-reference-objects, all 100 times more accurate than nowadays; specifications to purchase and to verify a machine; a means to measure inside holes with sub-micrometer radii, on steep slopes and behind obstructions; a changing capability for the probes; software suitable for feature extraction from measurements with changing probes; rules and standards concerning tolerances of nm features; concepts to find microscopic features (not breaking the probe); stable metrology frames to measure the same object with different probes in one coordinate system; concepts to estimate measurement uncertainties; and a means to inform potential users about the new technologies... this list is the work programme for the project. The NANO-CMM project team comprises about 1/3 of Europe?s nano and micro metrology research community, covering all required disciplines, particularly two manufacturers of Nano CMMs of the first generation (non real 3D ones) plus a group of end-users. This assures to achieve the critical mass to carry out the fundamental research, development, and implementations, and qualifiy staff through research, and a continuation of networking with partners and others after the project has ended.",Universal and Flexible Coordinate Metrology for Micro and Nano Components Production,FP6,31 May 2011,01 December 2006,5499875.0 NANOCMOS,STMicroelectronics SA,information and communications technology,"NANOCMOS is a project integrating in a coherent structure, activities that in the past have been the object of ESPRIT/IST, JESSI/MEDEA projects in the field of CMOS technologies. It focuses on the RTD activities necessary to develop the 45nm, 32nm and below CMOS technologies. From these technology nodes it will be mandatory to introduce revolutionary changes in the materials, process modules, device and metallisation architectures and all related characterization, test, modelling and simulation technologies, to keep the scaling trends viable and make all future IST applications possible. NANOCMOS covers all these aspects. The project include as well important Training and Dissemination activities. A professional Management structure will be implemented. The first objective of the project is the demonstration of feasibility of Front-End and Back-End process modules of the 45nm node CMOS logic technology. The project intents to process as demonstrator a very aggressive SRAM chip displaying worldwide best characteristics. This objective will be achieved within two years from project start. The second objective of the project is to realize exploratory research on critical issues of the materials, devices, interconnect and related characterization and modelling to start preparing the 32/22 nodes considered to be within the limits of the CMOS technologies. The third objective of the project is to prepare the take up of results described in the Objective I and implement a 45nm Full Logic CMOS Process Integration in 300 mm wafers by the end of 2007. This integration will be part of a separate MEDEA+ project. NANOCMOS initial Consortium gathers most of best competences existing in Europe in the domain. It is expected to incorporate new partners, to fulfil already identified tasks. NANOCMOS places Europe on a privileged position in the competition to develop the enabling technologies of the 2010 e-Society.",'CMOS backbone for 2010 e-Europe 'NANOCMOS' From the 45 nm node down to the limits',FP6,30 June 2006,29 February 2004,2.4167E7 NANOCOAT,Department of Atomic Energy (DAE),information and communications technology,"Use of self-lubricated coatings in dynamic contacting parts of the system not only reduces complexity, weight, and cost to the system, but also improves the performance to a great extent by reducing friction and wear. Unlike liquid lubricants, the release of various toxic and harmful chemicals to the environment can also be avoided. So, a self-lubricated surface with a long lifetime is a promising one to meet future challenges. The most common solid lubricants are graphite and transition metals layered dichalcogenides, among which MoS2/WS2 has a great prominence. In this proposal, electrodeposition of Co-W alloys impregnated with MoS2 and WC nanoparticles will be carried out to form nanocomposite coatings by a low cost electrodeposition process. The idea is to impart high hardness and mechanical strength by WC particles for wear resistance; and self-lubrication property by MoS2 particles to a Co-W matrix. Firstly, unlike ELECTROLYTIC CO-DEPOSITION from suspensions of MoS2 nanoparticles, here, emphasis will be on the in-situ formation of MoS2 particles in the electrical double layer followed by their incorporation into Co-W alloys during electrolytic reduction process. Secondly, R&D efforts will be directed to co-deposit WC particles from suspensions along with MoS2 to make self-lubricated wear-resistant nanocomposite coatings. The detailed mechanistic study of MoS2 nucleation and growth; the surface and structural characterization of the nanocomposite coatings, wear and friction property and corrosion will be investigated to understand the structure property correlation. Thirdly, the electrodeposition of Co-W+WC+IF-MoS2 nanocomposite coatings will be carried out from electrolytic suspensions of WC and IF-MoS2 nanoparticles, and the properties will be compared with the former nanocomposites. A special attention will be given on the onset of an implementation of this technology into industrial practice.",Development of Self-lubricating Nanocomposite Coatings impregnated with in-situ formed MoS2 for Tribological Applications,FP7,05 July 2014,06 January 2011,15000.0 NANOCOAT,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"Use of self-lubricated coatings in dynamic contacting parts of the system not only reduces complexity, weight, and cost to the system, but also improves the performance to a great extent by reducing friction and wear. Unlike liquid lubricants, the release of various toxic and harmful chemicals to the environment can also be avoided. So, a self-lubricated surface with a long lifetime is a promising one to meet future challenges. The most common solid lubricants are graphite and transition metals layered dichalcogenides, among which MoS2/WS2 has a great prominence. In this proposal, electrodeposition of Co-W alloys impregnated with MoS2 and WC nanoparticles will be carried out to form nanocomposite coatings by a low cost electrodeposition process. The idea is to impart high hardness and mechanical strength by WC particles for wear resistance; and self-lubrication property by MoS2 particles to a Co-W matrix. Firstly, unlike ELECTROLYTIC CO-DEPOSITION from suspensions of MoS2 nanoparticles, here, emphasis will be on the in-situ formation of MoS2 particles in the electrical double layer followed by their incorporation into Co-W alloys during electrolytic reduction process. Secondly, R&D efforts will be directed to co-deposit WC particles from suspensions along with MoS2 to make self-lubricated wear-resistant nanocomposite coatings. The detailed mechanistic study of MoS2 nucleation and growth; the surface and structural characterization of the nanocomposite coatings, wear and friction property and corrosion will be investigated to understand the structure property correlation. Thirdly, the electrodeposition of Co-W+WC+IF-MoS2 nanocomposite coatings will be carried out from electrolytic suspensions of WC and IF-MoS2 nanoparticles, and the properties will be compared with the former nanocomposites. A special attention will be given on the onset of an implementation of this technology into industrial practice.",Development of Self-lubricating Nanocomposite Coatings impregnated with in-situ formed MoS2 for Tribological Applications,FP7,12 February 2010,12 March 2008,224989.69 NANOCOAT,"International Project management, Plating and Materials",manufacturing,"The objective of the proposed research is to develop improved functionality and new coating applications for aluminium anodisation processes in surface engineering. Project will advance recent innovations towards preparation of ordered nanoporous, nanostructured materials using anodisation methods and applying them to develop commercially relevant novel materials and address the market potential for these improved materials. The nanostructuring process is the growth, during the anodising process, of nanoporous films consisting of well-ordered pores of Anodic Al Oxide in hexagonally close-packed distribution with large aspect ratio. The concept of self-assembly is not yet implemented in actual anodising Al processes due to a number of bottle-necks; project aims at developing pilot line equipment and methodologies enabling to overcome them. The objective is to solve actual market needs by achieving the single stage treatment and industrial evaluation of nanostructured aluminium alloys. The overall research methodology of the Nanocoat project will follow a progression from detailed laboratory studies through scale-up to applications testing on industrial aluminium grades under industrial relevant conditions, to evaluate their structural and functional characteristics, the reproducibility of the process, and to deliver to end-users suitable test structures as predemonstrators. It is expected that on controlling the formation of the anodised nano-size cell structures on aluminium it will be possible to achieve novel performance in terms of adherence, wettability, corrosion and wear, and adsorption/absorption properties. The scope of applications is very large in the field of surface engineering. The specific anodising markets to be addressed during the project are concerned with improved functionality and new coatings for traditional anodisation processes. In addition, new markets will be assessed, which are based on the enhanced performance of these coatings.",Nano-structured Aluminium Oxide Coatings,FP7,11 June 2014,12 January 2010,1144000.0 NANOCOFC,Royal Institute of Technology * Kungliga Tekniska Högskolan,energy,"The project aims to enhance research capacities on nanotechnology, multi-functional materials and advanced applications. Material innovations and advances are created on the multi-functional nano-composites concerning superionic conduction; hybrid H+/O2- conduction; nano-composite ionics; and next generation fuel cell technology. The project objectives are: (a) To extend the existing Turkish cooperation and Sino-Swedish IT/LTSOFC (intermediate and low temperature solid oxide fuel cell) network with prominent research institutions in EU; to network research cooperation and joint activities; to develop centers? infrastructure and research or innovation strategies. (b) exchanging and sharing personnel, information, resources and research methodologies. (c) training researchers and organizing the seminars, organize research plan and explore new research subjects on the related areas; senior researchers' visits to strength and develop research links with EU institutions, improve research methodologies and skills. (d) Various joint PhD and Postdoctoral programs build highly qualified, well trained research team and bring new skills together; to expose center fellows/scientists and students from different cultural and scientific background; through various means of supports to increase women students/scientists in the center. (e) enhancing its research infrastructures, thus, raising the capabilities and standards of the center to EU level, mobilize the existing human and material resources in the center, promoting the trans-tech. and research achievements to industry and to establish new ways of production research in cooperation with China and Turkey.",Enhancement of Research Capabilities on Multi-functional Nanocomposites for Advanced Fuel Cell Technology through EU-Turkish-China Cooperation,FP6,31 October 2009,01 November 2006,500000.0 NANOCOM,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"Future wireless systems will have to achieve self-reconfigurable operations for real time efficient optimization of their performances. RF-MEMS switches will allow to face this challenge and open the route towards reconfigurability of high power systems, but their reliability is still nowadays an issue. The aim of NANOCOM project is to develop a new approach for future generation of smart systems by introducing nanostructured materials capacitive MEMS to improve the reliability by one order of magnitude. NANOCOM aims to address the dielectric charging effect which limits the lifetime and to enhance the thermal performances of the device, increasing the power handling capability. The main objectives of NANOCOM are:1)explore new nanostructured materials to be used as dielectrics in RF-MEMS devices to achieve higher reliable devices by minimizing charging effects and improving thermal dissipation under high power. High-k dielectrics such as PZT with a fine control of the nanostructure and composites, aligned Carbon Nanotubes in a Si3N4 matrix and doped poly crystalline diamond as well as diamond nanopillars.2) develop the design methodologies and technological process to achieve the integration of these MEMS switches in phase shifters and SPDT devices.3) develop gas and pressure sensors and actuators of unprecedented performance that can be integrated with RF components of the same type to perform complex functions such as sensing/actuating combined with wireless transmission of data. Components of this type can improve the energy efficiency of systems by leading to efficient power supplies with intelligent energy control while allowing at the same time an increase of safety and functionality. 3 demonstrators will be fabricated by implementing them in a reconfigurable T/R module, a tunable filter and a reflect array antenna. The consortium possesses the experience to undertake this ambitious task. It is composed of 16 partners originating from 6 European countries.",Reconfigurable Microsystem Based on Miniaturized and Nanostructured RF-MEMS,FP7,01 January 2014,02 January 2011,930284.0 NANOCOM,University of Eastern Finland * Itä-Suomen Yliopisto,photonics,"In the search for new materials with enhanced functionality, glassy nanocomposites comprising of nanoparticles of different nature in glassy matrix are of special interest. In the case of metal nanoparticles this is because the pronounced surface plasmon resonance, which dominates the optical properties of glass-metal nanocomposites (GMN) and provides high optical nonlinearity of GMN due to additional enhancement of the electric filed in the vicinity of the nanoparticles. This resonance can be coupled to other resonances of different nature, like Bragg-type resonance mode in periodic medium or resonant electronic transition in glass doped with ions of rare-earth or tran-sition metals. The strong coupling of surface plasmon to other resonant modes differing in origin can dramatically enrich the optical properties of GMN enabling photonics materials with strong and fast optical nonlinearity and spectral tunability. Modification of metal nanoparticles with, e.g., femtosecond laser irradiation can modify spectral properties and even change the temporal dynamics of the plasmon mode and such manner enrich functionality of the GMN. In the framework of the NANOCOM we will develop innovative approach to development of novel materials based on nanostructuring glassy composites and will create such materials. The research objectives of the NANOCOM are modeling, manufacturing and investigation of (i) sub-micron patterned nanocomposites, (ii) GMN comprising of bimetallic nanoparticles, and (iii) GMN modified with femtosecond laser pulses. We anticipate that theoretical and experimental results of NANOCOM will provide new insights in the mechanisms of the linear and nonlinear response of nanocomposites on electromagnetic fields. New functionalities arising from the coupling of resonant excitations of different ori-gin and to the modification of GMN response by fs laser processing will enable development of advanced glassy materials for photonic and electronic applications.",Nanostructured composite materials,FP7,31 March 2015,01 April 2011,161500.0 NANOCON,IMEP-LAHC Laboratory,information and communications technology,"This proposal is placed in the area of molecular spintronics, a multidisciplinary area of knowledge in between molecular magnetism, molecular electronics and surface science and deals with the integration of molecular materials in spintronic devices. The weak spin–orbit coupling and hyperfine interactions found in organic materials, along with its ease of processability and tunability, make molecules became serious candidates to substitute traditional metals and inorganic semiconductors or insulators in spintronics devices. This offers the possibility of constructing devices were spin–coherence will be maintained over times hardly conceivable only some years ago. Additionally the use of magnetic molecules in spintronics devices is the expected evolution to shift from molecular electronics area to molecular spintronics field. Through the deposition over surfaces of thin films, their integration into organic molecular tunnel juntions (OMTJs) and the study of the molecule-surface interfaces this project combines chemistry, surface science and spin-transport physics. This proposal will try to go beyond the current state-of-the-art in the field of molecular spintronics by using molecular materials as spin barriers in OTMJs and its ultimate goal is to perform magnetotransport measurements through conveniently nanostructured thin organic layers and molecular materials. Special attention will be paid to the molecule-surface interface, critical to correctly interpret transport measurements. It is divided in two main parts, the first one deals with the use of thin organic barriers, self-assembled monolayer or polymeric thin films, in the preparation of OMTJs (1. THIN FILM MOLECULAR SPINTRONICS) and the second one intend to measure transport properties of a single molecule magnet (SMM) spintronic device. (2. SINGLE-MOLECULE SPINTRONICS). In the nanodevice robust SMM of the Mn4 and polyoxometalate will be separated from the electrode by an organic spacer. During the development",Nanocontacted Thin Molecular Films for Spintronics,FP7,02 May 2014,03 January 2010,166145.6 NANOCOOL,Fundación Tecnalia Research & Innovation,energy,"Air-conditioning is a rapidly growing electrical end-use in EU. A/C systems reduce temperature of the ambient air while removing humidity. However such combined air conditioning/dehumidification is generally inefficient. A promising approach is represented by Hybrid Liquid Desiccant (HLD) systems, where the latent load is removed by a liquid desiccant dehumidifier, while the sensible load is removed by a conventional vapor compression air cooler. The heat required for regeneration of the liquid desiccants needs however to be provided by outer sources like natural gas or solar collectors. Furthermore almost all metal alloys are corroded by the most effective liquid desiccants. HLD systems are therefore not penetrating the market. Our goal is to develop an innovative HLD system in the range 100-200 kW, where waste heat from the condenser is used for regeneration of the desiccants. The energy demand by this process is 55% of the conventional technique. In cases of severe humid environments, like swimming pools, or kitchens, the energy savings can achieve easily levels of 65%-70%. Several innovative components have to be developed, namely: - Two multifunctional heat exchangers with high corrosion resistance for either water vapour absorption from the air flow or desiccant regeneration; - Development of a liquid-liquid heat exchanger with high corrosion resistance for desiccant regeneration process pre-heat (liquid-liquid desiccant). Based on the promising results of the FP7 Thermonano project, thermally conductive polymer nano-composites will be considered as material for these components and shaped into innovative engineered heat exchange surface. The partners foresee an initial market worth up to 180 MEuro by 2020, generating/maintaining 4000 job opportunities for skilled operators and installers. The partners expect that the intended HVAC solution will allow cumulative savings on energy bill of at least 60 MEuro with a pay-back time below 2 years in case of 50% use.",An Energy Efficient Air Conditioning systems with Temperature and Humidity independent controls based on the combination of a Liquid Desiccants Cycle with an adapted conventional air cooling system,FP7,29 February 2016,01 September 2012,3250000.0 NANOCOORD,University of Western Brittany * Université de Bretagne Occidentale (UBO),health,"In many strategic research areas, particularly in electronics and medicine, nanochemistry-based technologies have recently grown considerably owing to the specific properties of the nanoscale (e.g. room temperature superparamagnetism, quantum effects), which are hardly accessible by traditional chemical approaches. In this context, most of the actual research carried out on nanomaterials is looking at functionalizing the surface of nano-objects with selective organic / bioorganic entities to implement and tailor the resulting properties and applied perspectives. In contrast, the consideration of coordination entities, such as transition-metal complexes, on the surface of nano-objects is hitherto rather limited and remains to be investigated in a systematic way. The NANOCOORD project is tackling this purpose with a distinct and unexplored approach of associating coordination entities (CE) to the outer surface of inorganic nanoparticles (NP). Therefore, the proposed strategy is paving the way to specific and remarkable properties such as magnetic bistability or photo-dynamic therapy while enlarging the applications panel. The particular knowledge gap in this research area legitimates the development of the project that visions to exploit the distinctive attributes of nanochemistry and coordination chemistry to design innovative functional materials with complementary properties. In light of the numerous potential applications, it is crucial to stress that this multidisciplinary project does not claim to cover all the possibilities but aims at a more methodical exploration of such NP@CE heterostructures, via a judicious and initially restricted selection of two application fields of high impact: combination therapy and data storage. The potential outcomes are highly relevant from both a fundamental scientific and technological perspective.","Design, study and development of novel functional hybrid nanomaterials, which consist of a nanoparticle core and an unconventional shell of coordination entities with synergetic properties.",FP7,31 January 2017,01 February 2013,100000.0 NANOCOPS,University of Wuppertal * Bergische Universität Wuppertal,information and communications technology,"Designs in nanoelectronics often lead to problems that are large to simulate and that include strong feedback couplings. Industry demands to include variability to guarantee quality and yield. It also requests to incorporate higher abstraction levels to allow for system simulation in order to shorten design cycles, while preserving accuracy. The nanoCOPS project considers the simulation of two problem classes identified by industry:- Power-MOS devices, with applications in energy harvesting, and which involve couplings between electromagnetics (EM), heat, and stress, and- RF-circuitry in wireless communication, which involves EM-circuits-heat coupling and multirate behaviour, together with analogue-digital signals.Due to the market demands, the scientific challenges are to- create efficient and robust simulation techniques for strongly coupled systems, that exploit the different dynamics of sub-systems and that can deal with signals that differ strongly in the frequency range;- include variability such that robust design, worst case analysis, and yield estimation with tiny failures are possible (including large deviations like 6-sigma);- reduce complexity such that one can still vary parameters and such that the reduced models offer higher abstraction models that are efficient to simulate.Our solutions are- advanced co-simulation/multirate/monolithic techniques, combined with envelope/wavelet approaches;- new generalized techniques from Uncertainty Quantification (UQ) for coupled problems, tuned to the statistical demands from manufacturability;- enhanced, parameterized Model Order Reduction techniques for coupled problems and for UQ.All algorithms will be validated in the industrial design tools provided by our industrial partners.Our consortium covers extensive R&D experience in nanoelectronic IC simulation and complementary expertise. It includes seven universities, one research institute, two large-scale semiconductor companies, and two SMEs.",Nanoelectronic COupled Problems Solutions,FP7,10 July 2018,11 January 2013,3499000.0 NANOCORE,Acciona Infraestructuras SA,transport,"The main scope of the NANOCORE Project is the development of a new and cost-effective production technology for sandwich structures foam core materials with non-toxic flame retardants and enhanced mechanical properties. The primary reason for this new material development is the to meet the current European requirements of the REACH -Registration, Evaluation and Authorisation of Chemicals- legislation and achieve low Fire, Smoke and Toxicity (FST) values, according to the SOLAS reglations.",Development of a low FST and high mechanical performance nanocomposite foam core material for ferries and cruise ship superstructures”,FP7,08 July 2015,09 January 2011,0.0 NANOCOURIERS,"Institute of Technology, Tallaght",health,"The overall aim of this project is to synthesise and fully characterise new asymmetric functionalised nanowires and to investigate the capability of these fascinating materials to act as therapeutic transportation tools in nanomedicine. Given suitable choice of materials these 'NanoMotors' can be displaced via catalytic decomposition of a fuel which leads to self electrophoretic propulsion towards one end of the nanowire. The unique features of these nanodevices will be tested for the directed delivery of 'clot buster' drug cargos. Such nano delivery systems aim to render delivery specifically to the site of disease, improving stability, loading and bioavailability of their cargos. The provision of the human infrastructure requested here with essential background knowledge and expertise will contribute towards development of this emerging area within Europe. Our findings will have an impact on related fields such as nanosensors, material science and nanomedicine. The core objectives are: 1. Synthesis of modified nanowires enabling guided motion along a predetermined pathway. 2. Full characterisation of the nanomotors using advanced surface techniques and catalytic propulsion testing. 3. Bio-conjugation studies and assessment of protein binding and release options. These objectives will be achieved using innovations and tasks involving the use of specialist resources and techniques within the physical and surface sciences, which are available at the host institution at ITT Dublin. It is envisaged that this project will facilitate key knowledge transfer from Dr. Krishnakumar Pillai (an experienced researcher from India who is working in field of nanobiotechnology) to the host institution in Ireland. The research group involved has a proven capacity to absorb, retain and exploit such knowledge by appropriate means, bringing adding value and increased potential for international collaboration via spin-off projects in related areas.",Design of Mobile Catalytic Nanowires for Targeted Delivery of Therapeutics,FP7,02 January 2014,03 January 2012,273095.0 NANOCPPS,Consejo Superior De Investigaciones Científicas (CSIC),health,"Metastatic neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in pediatric oncology (20%). Moreover its prognosis is very poor, practically incurable, what shows the inability of nowadays chemotherapy to eradicate all the illness, underlining the need for novel therapeutic approaches. A current study of the European Group for study of the Neuroblastoma has shown profits in the survival of patients by means of the combination of several drugs (protocol COJEC: vincristine, carboplatin, etoposide and ciclofosfamide). However, such treatment shows a very important deep medullary aplasia as a secondary effect. Our hypothesis is that encapsulation of the NB drug cocktail can significantly improve nowadays disease treatment in such: I) will protect drugs from degradation before reaching cancer cells, II) will ensure their simultaneous actuation and III) last but not least, it will allow us to minimize undesirable medullary aplasia side effects upon specific vectorization of the drug cocktail to the target cells with targeting agents able to address GD2, a glycolipid highly expressed on the cell surface of neuroblastoma. Such exigent specifications require a unique multifunctional system that not all the reported drug carriers can achieve. Our choice is a new family of coordination polymer (CP) nanoparticles rrecently used with this aim by the host group due to their advantages: I) can encapsulate multiple active principles with high yield within the same particle, II) the presence of biocompatible metal ions can add additional fluorescence properties that allow us to follow the cell internalization and biodistribution, III) nanoparticles can be functionalized with specific targeting biomolecules and IV) preliminary in vitro cytotoxicity assays already showed that the encapsulated drugs could be effectively used to induce the cell death.",Developing smart Coordination Polymer Nanoparticles as Biomedicine for Metastatic Neuroblastoma,FP7,,,173370.0 NANOCTM,Lancaster University,information and communications technology,"The NanoCTM network will tackle major challenges in the theory of nanoelectronics. Ten internationally-leading European theory-of-condensed-matter groups from nine different countries [including one of Europe’s leading industrial electronics-research groups (QinetiQ)] have joined forces as full participants, combining theoretical expertise in nanowires, quantum dots, carbon-based electronics, and spintronics, along with interaction and proximity effects in small dimensions. Our highly-integrated approach to nanoscale transport will represent a major step towards the realisation of future scalable nanotechnologies and processes. In the longer term, the insights gained will contribute to the fabrication of novel functional nanoscale architectures and their integration into a higher hierarchical level. System parameters such as electric field, light, temperature or chemical reactivity are envisaged as possible drivers of future nanoelectronic devices.","Nanoelectronics: Concepts, Theory and Modelling",FP7,12 July 2015,01 January 2010,2466208.21 NANODAOHP,University of Leeds,energy,"Developing sustainable solar energy technology becomes extremely important to secure our energy future. A highly novel solar thermal technology, from both nanotechnology and phase change approaches, is proposed in this project to address the limitations associated with conventional solar thermal collectors. In this innovative technology, direct absorption nanoparticles are used to overcome the surface-controlled heat transfer limitation and absorb solar energy directly in the carrying fluid, and oscillating vapour bubbles (in oscillating heat pipes) are used to drive the fluids instead of pumps. Preliminary studies have shown the feasibility of the new concept, which has both prosperous scientific and applicaton propsects. Scientifically, it extends the direct absorption nanoparticles into a phase change domain, and practically it could promote the emergence of a new generation of solar collector. A systematic program is proposed in this project to address the challenges associated with the novel concept, which extends from suitable direct absorption nanofluid formulation, understanding the role of nanoparticles in the evaporation and condensation process, to its performance in ossillating heat pipes. The project is an ambitious, highly novel piece of work ideally suited to a Fellow with a strong background in solar energy and thermal science and engineering. The Fellow in question, Dr Lizhan Bai is perfectly (perhaps uniquely) suited to drive this project to success as he has independently designed, constructed and experimented with a number of challenging flow and heat transfer devices, especially heat pipe systems, and has outstanding analytical and mathematical modelling capability, which will contribute uniquely to the project. It will allow significant knowledge transfer into Europe, especially heat pipe systems, and create potentials long term collaborations and mutually beneficial co-operation between Europe and China.",Nanoparticle based direct absorption oscillating heat pipes for solar thermal systems,FP7,31 August 2016,01 September 2014,221606.0 NANODAOHP,Beihang University,energy,"Developing sustainable solar energy technology becomes extremely important to secure our energy future. A highly novel solar thermal technology, from both nanotechnology and phase change approaches, is proposed in this project to address the limitations associated with conventional solar thermal collectors. In this innovative technology, direct absorption nanoparticles are used to overcome the surface-controlled heat transfer limitation and absorb solar energy directly in the carrying fluid, and oscillating vapour bubbles (in oscillating heat pipes) are used to drive the fluids instead of pumps. Preliminary studies have shown the feasibility of the new concept, which has both prosperous scientific and applicaton propsects. Scientifically, it extends the direct absorption nanoparticles into a phase change domain, and practically it could promote the emergence of a new generation of solar collector. A systematic program is proposed in this project to address the challenges associated with the novel concept, which extends from suitable direct absorption nanofluid formulation, understanding the role of nanoparticles in the evaporation and condensation process, to its performance in ossillating heat pipes. The project is an ambitious, highly novel piece of work ideally suited to a Fellow with a strong background in solar energy and thermal science and engineering. The Fellow in question, Dr Lizhan Bai is perfectly (perhaps uniquely) suited to drive this project to success as he has independently designed, constructed and experimented with a number of challenging flow and heat transfer devices, especially heat pipe systems, and has outstanding analytical and mathematical modelling capability, which will contribute uniquely to the project. It will allow significant knowledge transfer into Europe, especially heat pipe systems, and create potentials long term collaborations and mutually beneficial co-operation between Europe and China.",Nanoparticle based direct absorption oscillating heat pipes for solar thermal systems,FP7,31 October 2017,01 November 2016,15000.0 NANODARTS,"Pera Innovation, Ltd.",health,The majority of infections affecting man and animals take place or start at mucosal membranes.The ability to retain pharmacologically active agents for extended periods of time on any mucosal epithelia including those of the nose mouth rectum or vagina confers a number of potential therapeutic advantages The Wider Society and Policy Objectives of our Project We aim to benefit European society by reducing the length of localized topical treatment for mucosal infections by 50 and the pain experienced by 40 The relatively low cost of the Nano DARTS technology will enable the increasing use of this local topical application in all European countries including the Eastern Europe and this will support the policies of the European Union to bring the health of Eastern Europeans up to the same standard as those of the 15 states To achieve this our Technical Targets are to discover technological routes to enable the development of an advanced nanosized polymer coated liposome system compatible with carrying hydrophilic or hydrophobic drugs of varying sizes or both simultaneously that are retained at the mucosal site of application and release the active ingredient in a controlled manner for local and or systemic absorption The Economic Objectives to Improve competitiveness This project will strengthen the competitiveness of our group of participant SMEs and subsequent licensees to gain a 5 share of the per annum approx 2 billion growth of global market for advanced topical mucosal drug delivery systems by 2014 and create 1 250 new European jobs In addition this project will contribute towards implementing the goals set by the EU in 2005 which includes increased innovation and investment in the pharmaceutical and biotechnology industries to regain European global competitiveness in this sector by offering this sector product differentiation and life cycle management opportunities,Nanosized polymer coated liposome system for enhanced mucosal drug delivery,FP6,30 June 2008,01 July 2006,803882.0 NANODAT,Cranfield University,health,"Globally, there is a growing problem of drug driving. It is believed that drugs of abuse contribute to up to 25% of fatal road accidents. Governments worldwide are introducing legislation for road side testing. As yet no suitable instrument is available on the market. The routine test for the detection of drugs measures the level of metabolite in urine, which is not practicable for road side testing nor indicates drugs taken in the last few hours. Detecting drug traces directly in oral fluid has been identified as the best roadside method of detection. There are significant challenges as the sample is small and detection levels are ppb. A global need exists for a cheap, drugs of abuse test (DAT) using saliva for roadside use by people who are not medically trained. NanoDAT addresses these issues by introducing a technology, based on molecular imprinted polymers (MIPs), to a DAT sensor platform. MIPs can replace costly and less stable antibodies leading to mass-producible and cost-effective systems for DAT applications. The shelf life of the systems will be improved by a factor of at least ten. The basic concepts and knowledge to be developed and transferred have widespread applicability in fields outside of DAT such as clinical and environmental process control. The main scientific and technological objective of NanoDAT is the design of a miniaturised sensor technology as a platform for detection of relevant drug analytes and their metabolites. The nanostructured biomimetic materials will overcome both the stability and short shelf life problems inherent to antibody based systems. Microfluidic devices will also be developed that need minimal sample volumes. Integrated photonic detection will provide a rapid, hand held detection technology. NanoDAT is a significantly multidisciplinary Marie Curie project with participation from chemists, computational materials scientists, physicists, microfluidic fabrication engineers and semiconductor technologists.",Engineering selective elements for disposable point of test sensor chips,FP6,31 August 2010,01 September 2006,811519.11 NANODEFINE,Stichting Dienst Landbouwkundig Onderzoek * Foundation for Agricultural Research,environment,"Nanotechnology is a key enabling technology. Still existing uncertainties concerning EHS need to be addressed to explore the full potential of this new technology. One challenge consists in the development of methods that reliably identify, characterize and quantify nanomaterials (NM) both as substance and in various products and matrices. The European Commission has recently recommended a definition of NM as reference to determine whether an unknown material can be considered as 'nanomaterial' (2011/696/EU). The proposed NanoDefine project will explicitly address this question. A consortium of European top RTD performers, metrology institutes and nanomaterials and instrument manufacturers has been established to mobilize the critical mass of expertise required to support the implementation of the definition. Based on a comprehensive evaluation of existing methodologies and a rigorous intra-lab and inter-lab comparison, validated measurement methods and instruments will be developed that are robust, readily implementable, cost-effective and capable to reliably measure the size of particles in the range of 1–100 nm, with different shapes, coatings and for the widest possible range of materials, in various complex media and products. Case studies will assess their applicability for various sectors, including food/feed, cosmetics etc. One major outcome of the project will be the establishment of an integrated tiered approach including validated rapid screening methods (tier 1) and validated in depth methods (tier 2), with a user manual to guide end-users, such as manufacturers, regulatory bodies and contract laboratories, to implement the developed methodology. NanoDefine will be strongly linked to main standardization bodies, such as CEN, ISO and OECD, by actively participating in TCs and WGs, and by proposing specific ISO/CEN work items, to integrate the developed and validated methodology into the current standardization work.",Development of an integrated approach based on validated and standardized methods to support the implementation of the EC recommendation for a definition of nanomaterial,FP7,10 July 2019,11 January 2013,6999283.0 NANODEM,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Project aim is the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the measurement of immunosuppressants and related metabolites in transplanted patients. The new device will allow the automatic measurements of therapeutic drugs and metabolites characterized by a narrow therapeutic range and serious potential side effects. Clinical benefit will be an optimized dosage of the respective therapeutical drug. The patient will be connected to the device by an intravenous microdialysis catheter to allow 48-h online measurements. Based on this minimally-invasive approach, the therapeutic drugs and related metabolites will be monitored at short time intervals. The need of mixing the dialysate with the chemical reagents and the necessity of incubation times for the bioassay implementation, unavoidable procedure for bioanalyte detection, implies that a continuous measurement of such analytes is impossible, but the miniaturisation down to micro- and nano-scales will lead to very short time intervals, of the order of a few minutes. Heart of the device will be a multi-parametric optical chip, which will make use of the recent developments in nanotechnology to convert the concentration changes of the analytes in detectable luminescent signals. Essential sections of the device will be also: i) the microfluidic circuit before the chip, where the dialysate is mixed with the reagents necessary for the implementation of the biological assay; ii) the optical detection system which must be characterised by high efficiency and strong compactness; iii) the compact hardware control unit and user interface that allow instrument control and data handling. The integration of all these sections within the POCT stand-alone device requires the convergence of competences ranging from chemistry and biochemistry to optics and medicine as well as the convergence of micro and nanotechnologies, such as micro/nanofluidics,microdialysis and micro/nanosensing.",NANOphotonic DEvice for Multiple therapeutic drug monitoring,FP7,30 September 2016,01 October 2012,3983000.0 NANODETECT,ttz Bremerhaven,health,"In NANODETECT, the nanoreaction technology will be used to develop on-line and off-line monitoring systems (sensors) which combine the expertise of sensitive molecular biological processes with the potency of nanotechnology for application in liquid process food streams. The nanosensors will interact with information technology tools and thus contribute to improved quality control systems within small and large industries. The partners have chosen milk as example process stream because it is subject to different contaminations of which the following were chosen as models: Pathogenic microorganisms (e.g. Listeria monocytogenes), Mycotoxins (e.g. Aflatoxin M1), Drug residues (e.g. sulphonamides) and Fraud (e.g. high value goat milk blended with cow milk). The nanosensors will work on different types of immunoassays, depending on the application. Single modules will be developed for the detection and quantification of specific contaminants which can be combined according to user's requirements. It is planned to develop on-line systems with suitable software and automated decision support systems (DSS) for large industries as well as bench top and or handheld devices for small companies with flexible production units. Up to now, there is no technology available for the rapid, in-situ recognition and quantification of unwanted substances in liquid process streams. The device includes a dedicated nanosystem for sample preparation that allows the passage of each molecule of the process stream and associated immuno-assays for the direct quantification of the contaminants in the process stream. The novel sensor will comprise activated nanostructures and innovative techniques for a specific concentration within sample preparation and analysis, respectively. This innovative technology features advantages such as significantly lower costs, high conversion rates, direct quantification, and to be realized as in-line as well as bench top and or handheld device.",Development of nanosensors for the detection of quality parameters along the food chain,FP7,29 February 2012,01 September 2008,2108788.0 NANODETECTOR,Brandenburg University of Technology Cottbus-Senftenberg * Brandenburgische Technische Universität Cottbus-Senftenberg,photonics,"Controlled or uncontrollabel disposing of nanoparticles in various components of man made or biological matter, may have wanted or undesired consequences. Developing the diagnostic tools to detect and characterize the 'grey goo' is one of the challeneges of nanotech-era. A development of general technology for detection and analysis of single nanoparticles in complex environment and a development of a laboratory prototype of the device based on this technology and its application are the goal of this project. The proposal is based on the new experimental phenomenon discovered recently by a project partner: single subwavelength objects give rise to giant optical signals in surface plasmon resonance microscopy. This provides a unique possibility for ultrasensitive on-line detection of engineered nanoparticles. Within the project a development of the device for detection of nanoparticles and its application for a number of practically important tasks will be performed. The work includes a development of theoretical description of the new effect, optimization of main components of the detection system, development of sophisticated software for effective image analyses and isolation of nanoparticle signals from background optical signals and noise. Preliminary experiments demonstrated a possibility to use surface modification to distinguish different types of nanoparticles. Within the project this approach will be used for identification of nanoparticles. Measurements will be performed in aqueous media as well as in air. Inorganic, plastic and protein nanoparticles will be examined. At the final step of the project monitoring of nanoparticles in simple (drinking water, mineral water, air) and complicated (wine, juice and other transparent non-colloidal drinks) will be performed. The end users will test the developed experimental system for monitoring of workplaces and waste during production of inorganic and protein nanoparticles.",Ultrasensitive plasmonic detection of single nanoparticles,FP7,30 November 2015,01 June 2012,2967949.0 NANODEV,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,health,"This project is a merging of the original proposals 510103 (NANODEV) and 510107 (MOECAB). NANODEV deals with nanotechnology, while MOECAB deals with blood sensing, hereinafter referred to as subproject 'Nanotechnology' and subproject 'Blood Sensing'. Subproject 'Nanotechnology'. At present nanoscience mainly deals with the building blocks, whereas the development of devices is in an embryonic stage. The subproject aims at the development of industrial implementation of nanotechnology and comprises the study of semiconducting nanowires and new nanoscale electronic devices, in particular sensors with single-molecule sensitivity and nanosized memory cells. To achieve these goals, ToK experts should strengthen the subproject's knowledge base regarding one-dimensional materials and structures, sensors and memories. The combination of scientifically experienced fellows together with the application knowledge present in the host organisation can fulfil the goal to translate knowledge on nanoscience into new and groundbreaking devices. Subproject 'Blood Sensing'. Blood testing is a major industry in health care and a standard procedure in hospitals. Also at home, blood testing is inevitable for diabetes patients who test their blood glucose levels various times every day. In the EU 3-4% and the USA 6-8% people are diagnosed with diabetes. Currently, blood testing is done using a needle. The need for non-invasive blood analysis is crucial for improving diabetes treatment. At Philips Research a new non-invasive method is being explored. The challenge is to strongly reduce the cost price of the system, to realize introduction on the health care market. The subproject proposes development of multivariate optical element (MOE) technology to implement spectral analysis in low cost hardware. MOE technology is new to Philips and requires a researcher with relevant experience. The project is thought to strengthen the European competitiveness towards USA and the rest of the world.",Medical Sensing and Nanodevices,FP6,31 March 2008,01 April 2004,580066.0 NANODEVICE,Finnish Institute of Occupational Health * Työterveyslaitos,environment,"Due to their unique properties, engineered nanoparticles (ENP) are now used for a myriad of novel applications with great economic and technological importance. However, some of these properties, especially their surface reactivity, have raised health concerns, which have prompted scientists, regulators, and industry to seek consensus protocols for the safe production and use of the different forms of ENP. There is currently a shortage of field-worthy, cost-effective ways - especially in real time - for reliable assessment of exposure levels to ENP in workplace air. In addition to the problems with the size distribution, a major uncertainty in the safety assessment of airborne ENP arises from the lack of knowledge of their physical and chemical properties, and the levels of exposure. A special challenge of ENP monitoring is to separate ubiquitous background nanoparticles from different sources from the ENP. Here the main project goal is to develop innovative concepts and reliable methods for characterizing ENP in workplace air with novel, portable and easy-to-use devices suitable for workplaces. Additional research objectives are (1) identification of relevant physico-chemical properties and metrics of airborne ENP; establishment of reference materials; (2) exploring the association between physico-chemical and toxicological properties of ENP; (3) analyzing industrial processes as a source of ENP in workplace air; (4) developing methods for calibration and testing of the novel devices in real and simulated exposure situations; and (5) dissemination of the research results to promote the safe use of ENP through guidance, standards and education, implementing of safety objectives in ENP production and handling, and promotion of safety related collaborations through an international nanosafety platform.","Novel Concepts, Methods, and Technologies for the Production of Portable, Easy-to-Use Devices for the Measurement and Analysis of Airborne Engineered Nanoparticles in Workplace Air",FP7,03 July 2015,04 January 2009,9490888.0 NANODIA,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"The aim of the proposed project is to initiate a new research line on the development of nano-diamond building blocks for micro-devices. Diamond is a superlative engineering material combining exceptional thermal, mechanical, and chemical properties. Nano-grained diamond is of large scientific and technological interest since it could lead to several breakthroughs in micro-engineering, like e.g. for the synthesis of micro-electromechanical systems. Such nano-diamond deposits could replace silicon and other well-established materials that are unsuitable under extreme conditions, and could help to tackle the reliability issues due to friction and wear in numerous micro-device applications. This project will address several key aspects related to the growth, structure, and function of nano-diamond deposits that still impede their breakthrough for micro-scale applications.",Nano-diamond building blocks for micro-device applications,FP7,09 June 2015,10 January 2011,0.0 NANODIAMOND,University of Kassel * Universität Kassel,information and communications technology,"Nanocrystalline diamond (NCD) films are expected to possess the superior properties of diamond combined with smooth surfaces anda low stress. The scientific objectives of the project include the investigation of the deposition, characterization and technological applications of NCD/a-C composite films. The films composed of NCD (with grain sizes up to 10 nm) dispersed in an amorphous carbon matrix (a-C) will be prepared by microwave plasma chemical vapor deposition (MWCVD) and will be optimized concerning not only the crystallite size but also the nature of the matrix and especially regarding the combined effect of both components of the composite on the film properties for advanced applications. The obtained layers will be thoroughly investigated with respect to their basic (crystallite size, morphology, bonding structure of the matrix, composition of the matrix) and application relevant (deposition area, homogeneity, hardness, friction coefficient, stress, biocompatibility, etc.) properties. The possible applications of NCD/a-C films as wear resistant coatings for biomedical purposes and as a new material with extreme properties in micro-an nanostructure technology (for MEMS, AFM tips, membranes ) will be evaluated. The training objetives of the proposal are closely related to the scientific ones and include gaining of knowledge for new deposition techniques, appropriate for preparation of advanded materials, for new analytical techniques, as a part of th e extensive characterization necessary for the thourough investigation of the materials and for testing of the functionalities of the materials with the application of multidisciplinary approaches, e.g. microtechnology, biological and chemical methods.",Advanced technological applications of nanocrystalline diamond/amorphous carbon composite films,FP6,30 April 2006,01 May 2004,212955.0 NANODIARA,EA European Academy of Technology and Innovation Assessment GmbH,health,"Based on the clinical unmet needs and recent research in biomarkers on Rheumatoid Arthritis (RA) and Osteoarthritis (OA) the main objective of the project is to develop a nanotechnology based novel diagnostic tool for easy and early detection of biomarkers in inflammatory diseases especially RA and OA by using modified superparamagnetic nanoparticles (SPION) for (A) bioassay (ex-vivo application) and (B) MRI (in-vivo detection). A new technology based on multiple functionalized single nanoparticles specifically entering/attaching to cells, to enzymes in serous fluids or organelles in living cells will be used to detect, separate and identify low abundance biomarkers. Newly identified biomarkers will be used to decorate SPION with binding moieties which are specific to the biomarker(s) and can be used diagnostically such as in contrast agents (MRI). A sensitive micro-immunoassay will be developed for special use of these particles in biochemical tests for arthritis. This project is driven by the high clinical need to identify early arthritis and then segment RA and OA patients into progressors/responders or non-progressors/-responders to various treatment options. Inflammatory disorders like RA inducing the destruction of cartilage in ≈ 1% of the population which is accompanied by significant pain, morbidity and mortality leads to reduced capacity to work. OA, a degenerative arthritis is the leading cause of disability among the elderly population. As there is no cure for RA and finally the replacement of e.g. the knee in OA, early diagnostic tools for the detection of the disease progression and the ability to evaluate the efficacy of therapeutic interventions are necessary u.a. for drug development. Existing diagnostic methods often do not permit an early definite diagnosis, so new nanoparticle based diagnostic techniques targeting to the detection of molecular events (based on MRI) with higher sensitivity/specificity will be developed to satisfy the urgent need.",Development of novel nanotechnology based diagnostic systems for Rheumatoid Arthritis and Osteoarthritis,FP7,31 January 2014,01 February 2010,8917307.0 NANODIELECTRIC,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"Layered materials are particularly interesting for several reasons: First, they combine aspects of 3D and 2D systems that can be evidenced by studying their anisotropy; second, they are of high potential technological interest with applications such as solid state fuel cells; third, all laminar materials have been predicted to form nanotubes. The role of layered systems as a building block for various nanostructures suggests to call them 'nanomaterials'. Here we propose to study two prototype nanomaterials: GRAPHITE and BLACK PHOSPHORUS. Among the nanomaterials, graphite is particularly appealing as the starting material for synthesis of not only for carbon nanotubes, but also many other nanostructures such as fullerenes. It is a semimetal with an interesting anisotropic conductivity behaviour that can be analysed by the investigation of its dielectric properties. Black phosphorus is a layered compound with an insulating gap of 0.3eV at 1 atm and 300K. It becomes metallic upon application of pressure and at the melting point, showing a diagram with a series of phase transitions. It has a stable simple cubic phase at high pressure, contrary to the trend of high atomic coordination number observed in most materials under pressure. Our study will focus on electronic excitations in these materials, expressed in their optical and dielectric properties. To this aim, state-of-the-art theoretical and experimental techniques will be applied. Of special interest will be the pressure dependence of the calculated and measured quantities. This presents a triple interest: fundamental, to investigate the influence of pressure on various contributions such as excitonic effects or interlayer interactions; specific, to describe the fingerprints of stress, strain, and phase transitions in the dielectric properties; and prospective, since the properties of nanostructures are influenced by geometric constraints and interlayer interactions.",Dielectric Properties of Layered Nanomaterials,FP6,30 November 2006,01 December 2004,150237.0 NANODIGREE,National Technical University of Athens,information and communications technology,"Currently, display industries, LCD and OLED displays manufacturing is based on Indium-Tin Oxide (ITO) Transparent Conducting Films (TCF). Nevertheless, Indium metal is a very scarce material and its worldwide resources are becoming increasingly limited. Thus, the prices of produced displays based on ITO will inevitably rise day by day if no alternative material is developed to replace it. Moreover, ITO films have limitations in flexibility and this fact excludes them from application in the production of new-generation displays, such as electronic books and flexible displays.","Low-cost, Green, Large Scale Manufacturing of new age conducting nanowires displays",FP7,11 June 2017,12 January 2013,0.0 NANODIRECT,University of Leuven * Katholieke Universiteit Leuven,manufacturing,"The proposed research aims at developing a toolbox for direct self-assembly of nano-colloids. Different methods to drive and modulate self-assembly in nano-colloids will be developed, compared and evaluated. The toolbox will consist of the following elements : (i) Building blocks: model particles with varying shape, functionality and directional interactions will be synthesized (ii) Directing Tools : Electric and Flow fields, surfaces and interfaces (iii) Test and development methods : Experimental platforms adapted at nano-particle research and simulations methods, capable of dealing with a range of length scales. The proposal specifically aims to study these methods which are prone to scale-up The research consortium consists of leading groups in the filed of colloid science and engineering and soft matter research. The seeds of this toolbox are clearly present in the consortium including methods for production of model (field responsive) nanoparticles, unique experimental tools, theoretical skills and mesoscale simulation methods. The key idea is to gradually evolve in the research to be able to deal with smaller length scales and a wider range of directing fields .",Toolbox for Directed and Controlled Self-Assembly of nano-Colloids,FP7,08 July 2014,09 January 2008,3667067.0 NANODISCAN,University of Wolverhampton,health,"Most cancers remain 'incurable' and life-thretening. Cancer stem cells (CSCs) are the source of chemo/radioresistance and responsible for cancer recurrence which suggests the urgent requirement of CSC-targeting drugs. Drug development is a slow (15 years/drug) and costly (US$1.5bn/drug) procedure with only 5-25% of new oncology drugs in clinical development actually reaching the market mainly due to the toxicity of novel molecules. This dilemma has led to an increasing appreciation of the potential of repurposing of known drugs. We have demonstrated that Disulfiram (DS), an old anti-alcoholism drug, possesses excellent anti-CSC activity with low toxicity to normal cells. Whereas its cancer clinial indication is limited by its bio-instability (~4 min half-life in blood stream). Our pilot data demonstrated that the anticancer efficacy of DS is significantly improved when mild extending its half-life by liposome encapsulation. In this study, the Incoming Fellow, who has very strong technical knowhow in cancer research, molecular pharmacology, anticancer drug development and nano-encapsulation, will bring novel nano-biomaterials invented in China into Europe. Taking advantage of the state-of-the-art facilities, CSC models, pharmaceutical resarch and developmental expertise and scientific/technical support from the Incoming Host and the other European collaborators, we will develop a long-circulating nano-encapsulated DS. The anticancer activity of the nano-encapsulated DS will be examined in vitro and in vivo in breast and liver cancer cell lines as well as the relevant CSC models. This study will pave the path for clinical trial of DS in cancer indication. The significance of this project will be: 1. Expand and extend our FP7-IRSES (2011-16) platform to strenthen long-term collaboration between China and EU partners; 2. Develop a new cancer therapeutics for the benefic of healthcare in Europe; 3. Open a new drug developmental window to benefit European economy.",Nano-technology enabled repositioning of Disulfiram as an anti-cancer stem cell agent,FP7,04 June 2016,05 June 2014,299558.0 NANODISCAN,Fourth Military Medical University,health,"Most cancers remain 'incurable' and life-thretening. Cancer stem cells (CSCs) are the source of chemo/radioresistance and responsible for cancer recurrence which suggests the urgent requirement of CSC-targeting drugs. Drug development is a slow (15 years/drug) and costly (US$1.5bn/drug) procedure with only 5-25% of new oncology drugs in clinical development actually reaching the market mainly due to the toxicity of novel molecules. This dilemma has led to an increasing appreciation of the potential of repurposing of known drugs. We have demonstrated that Disulfiram (DS), an old anti-alcoholism drug, possesses excellent anti-CSC activity with low toxicity to normal cells. Whereas its cancer clinial indication is limited by its bio-instability (~4 min half-life in blood stream). Our pilot data demonstrated that the anticancer efficacy of DS is significantly improved when mild extending its half-life by liposome encapsulation. In this study, the Incoming Fellow, who has very strong technical knowhow in cancer research, molecular pharmacology, anticancer drug development and nano-encapsulation, will bring novel nano-biomaterials invented in China into Europe. Taking advantage of the state-of-the-art facilities, CSC models, pharmaceutical resarch and developmental expertise and scientific/technical support from the Incoming Host and the other European collaborators, we will develop a long-circulating nano-encapsulated DS. The anticancer activity of the nano-encapsulated DS will be examined in vitro and in vivo in breast and liver cancer cell lines as well as the relevant CSC models. This study will pave the path for clinical trial of DS in cancer indication. The significance of this project will be: 1. Expand and extend our FP7-IRSES (2011-16) platform to strenthen long-term collaboration between China and EU partners; 2. Develop a new cancer therapeutics for the benefic of healthcare in Europe; 3. Open a new drug developmental window to benefit European economy.",Nano-technology enabled repositioning of Disulfiram as an anti-cancer stem cell agent,FP7,,,15000.0 NANODNASEQUENCING,Institute of Physics * Institut za fiziku,health,"The demand for a next-generation of technologies for DNA sequencing that will provide fast and affordable DNA decoding is pressing. Present bio-chemical schemes are time consuming and expensive, thus cheap and fast alternatives for DNA 'reading' are of great need. This is now internationally recognized. For example, the US NIH recently awarded 40M$ in grants overpiloting projects to spur development of these innovative technologies. The goal of this project is to investigate a novel single-molecule DNA se-quencing nanotechnology protocol (gene sequencer) that has potential to sequence a molecule of genomic dimensions in hours without expensive and fault sensitive DNA copying steps and chemical reactions. The gene sequencer is based on the electrical characterization of individual nucleo-bases, while DNA passes through a nanopore with integrated nanotube side-electrodes. The research proposed here will provide a unique combina-tion of state of the art capabilities for cutting and usage of single wall carbon nanotubes as electrodes forming a lithographically fabricated 'nanogap' with single-nanometer precision. In addition, the synergy of consortium resources for electrical characterization and leading theoretical skills for nanotransport will provide new solutions and information for an answer on the proof-of-principle question: is it possible to detect different types of DNA bases by their electrical properties? The overall objective of our collaborative research is to develop cheap and high-speed DNA sequencing technology. This will be achieved trough the following steps: 1. Fabrication of single wall carbon nanotube junction-gate for molecular recognition; 2. Exploring the interaction and conduction mechanisms between DNA and nanotube-electrode and DNA-nanopore; 3. Electrical characterization of the DNA nucleobases; 4. Development of model nano-electronic device for single-base DNA electrical characterization and decoding.",NanoTools for Ultra Fast DNA Sequencing,FP7,30 November 2011,01 December 2008,2170925.0 NANODRUG,Queen Mary University of London,health,"The aim of the NANODRUG Network is to contribute to the defragmentation of the emerging field of nanomedicine by providing a unique training programme that will cover all different aspects ranging from NP synthesis and characterisation, drug delivery, molecular biology to nanotoxicology, preclinical studies, risk assessment and nanotechnology policy making. The NANODRUG training program is far superior to any training that individual partners can provide and will equip researchers with innovative and creative skills and enhance their career prospects in the public and private sectors. The scientific aim of this research training network is to develop and characterise a selected set of novel intelligent nanomaterials and to study their suitability as novel drug delivery systems targeting inflammatory skin diseases. The development and use of the NP described in this project aims to overcome the current difficulties that limit the applications of NP to skin drug delivery. The unique physico-chemical properties of these novel NP such as ultra small size, large surface to mass ratio, high reactivity and the capability to tailor them to applications will ensure that when complexed with drugs the pharmacokinetics and therapeutic index of the delivery systems can be significantly improved compared to the free molecules and the capability to pass the SC of the skin greatly enhanced. This project brings together 6 academic groups and 2 industrial teams as full partners, complemented by 3 associate partners, one of which is an industrial team, distributed over a total of 6 EU member states and 1 non-ICPC country. The consortium brings together groups with a very interdisciplinary expertise ranging from polymer synthesis and characterisation, computational modelling and physicochemical characterisation of materials to bioavailability, NP formulation, drug distribution and nanotoxicity, genetics, drug delivery and clinical dermatology.",Novel nanoparticles for drug delivery to the skin,FP7,31 October 2015,01 November 2011,3752752.0 NANODYGP,Abo Akademi University * Åbo Akademi,health,"Small GTPases of the Ras superfamily, a major class of signalling proteins, control critical cellular functions, such as proliferation, differentiation, migration and trafficking. Their misregulation is associated with severe diseases, such as cancer or neurodegenerative diseases. More than 150 Ras-like GTPase are known, which are divided into four major subfamilies, each containing between 22 to 63 structurally related, but functionally distinct isoforms. A fundamental unresolved biological question in the field is the structure-based mechanism, which guides isoform specific functions. Recently, we provided new structural insight on how Ras operates in the context of the membrane. We showed that Ras adopts isoform specific orientations on the membrane, which in turn critically regulate Ras activity. These orientations are guided by a new switch III region and are stabilized by the amphipathic helix α4 and the membrane anchoring, C-terminal HyperVariable Region (HVR). Intriguingly, these structural elements vary from one isoform to another also in other subfamilies, suggesting that this mechanism is also operative in them. We will therefore study, whether this mechanism that involves helix α4 and the HVR also define isoforms of the Rho- and Rab-subfamily. In parallel, we will investigate the molecular mechanisms that are relevant for the overall membrane organisation of GTPases. This includes studies on the dynamics of the orientation, as well as on the mechanism of the formation of nanoscale assemblies (nanoclusters) of GTPases on the membrane. We expect that our results have the potential to substantially transform the current understanding of GTPase functioning and answer a long-standing fundamental biological question. Moreover, both mechanisms represent new, specific targets for pharmacological interventions.",Nanoscale Operation and Dynamics of small GTPases - Identification of novel Isoform specifying Determinants,FP7,31 August 2014,01 September 2010,100000.0 NANODYN,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"We envision to develop a computational method base on first-principles (i.e., ab-initio) and empirical pseudopotentials that is, unlike any other method, able to treat the relevant size range of semiconductor nanostructres (i.e., between 1000 and one million atoms), on an atomistic footing, including dynamical effects at the many-body level. The method will be developed following a bottom-up approach, i.e., starting from the most accurate description available such as density functional theory. The vibrational and electronic properties obtained this way for small clusters consitute the back-bone of the method and will be used to construct a robust and accurate desciption based on classical force fields (for the phonons) and semiempirical pseudopotenitals (for the electrons). The results obtained, including electron-phonon coupling, will then be used in a configuration interaction approach that will give us access to the correlated many-body wave functions of the excitation. The developments lean on developments undertaken by the P.I. in the last 6 years and will be accurate and general; being able to deal with arbitrary shapes and a wide range of materials. From the resulting many-body wave functions (including phonons) a wide range of new physical effects will be available, such as electronic relaxation times, spin relaxation times, temperature effects, Raman spectra, Polaron couplings, photon linewidth, which are key components in fields such as quantum information/computing, spintronics, lasers, nano-electronic devices, photovoltaic and even medicine. Besides its relevance for nanotechnology, the development presented here will have a significant impact for basic science research. Many of the concepts valid in solid-state physics are challenged in the nanometer scale and many fundamental discoveries can be expected that cross the boundary of physics to chemistry and biology.",Theory of Dynamical Processes in Semiconductor Nanostructures,FP7,31 October 2012,01 November 2008,100000.0 NANODYNATCELLVATION,London School of Economics and Political Science,health,"The organization of the T-cell in its resting and activated state, specifically of plasma-membrane molecules involved in the triggering of the T-cell, is a long-standing and contentious research topic in molecular immunology. Understanding the molecular mechanisms involved at the nanoscale, i.e. at spatial scales below the resolution limit of conventional optical microscopy (< 200 nm) will find answers to still open questions, and offer new routes to immunotherapy. The proposed multidisciplinary project aims to bring close together super-resolution STED microscopy and membrane biophysics with molecular immunology. The proposed studies will follow a holistic approach and include the investigation of the functional associations of a multitude of molecules in T-cell triggering, ranging from the T-cell receptor and co-receptors, over other proteins such as kinases and phosphatases, to lipids and the cortical cytoskeleton. Using super-resolution STED and single-molecule microscopy (specifically STED and fluorescence correlation spectroscopy, STED-FCS) I will directly observe, determine, follow and evaluate nanoscale molecular interactions of these molecules from the resting state and early activation of the T-cell until the constitution of the immunological synapse. Besides a sophisticated design of the experimental conditions such as appropriate live-cell fluorescence labeling, biochemical treatments and choice of activating the T-cell, I will improve the STED-FCS technology towards multi-color observations allowing the determination of nanoscale dynamics and interactions of different specific molecules at the same time. With new molecular interactions highlighted, I will be able to better understand how T-cells sense antigen presenting cells and what molecular ramifications are involved during the constitution of the immunological synapse.",Nano -structural and -dynamic events in the T-cell activation,FP7,31 August 2017,01 September 2013,100000.0 NANOEAR,University of Tampere * Tampereen Yliopisto,health,"The goal of the NANOEAR consortium is to develop novel multifunctional nanoparticles (MFNPs), which are targetable, biodegradable, traceable in-vivo and equipped with controlled drug release. With over 44 million EU citizens with treatable hearing loss, and 40 000 profoundly deaf who can be benefit with MFNP-based novel cochlear implant, the inner ear is a unique target.Both a model for nervous system disorders and difficult-to-access body sites; it is isolated, with neural and vascular targets, and is immunoprivileged. Measures of function and structure are quantitative and precise. Highly penetrating delivery vehicles will be created to carry and release drugs precisely to targeted tissue sites and selected cells. Nanoparticles, dendrimers, micelles and polymer-protein complexes will be designed for delivery of drugs/genes to selected targets of the inner ear. Four EU/FDA approved degradable biomaterials will be tested for targeting, coating, toxicity and payload carrier capacity. Commercially available liposomes, encapsulated by polyethylene glycol (PEG), impregnated with drugs, and modfied with targeting ligands and signaling molecules (gadolinium) will be assessed for benchmarking purposes. The fabricated MFNPs will be applicable to wide variety of drugs (e.g. conventional therapeutics, growth factors, proteins, nucleic acids, steroids). We will demonstrate greater selectivity, reduced side effects and greater efficacy than possible with current drug delivery, and provide treatments not currently possible. As a demonstration milestone this IP will produce a novel human cochlear implant promoting improved cochlear nerve-implant integration. In this demonstration the implant will include a MFNP drug reservoir providing continuous drug delivery and MFNP electrode coatings providing targets for nerve growth.",3g-Nanotechnology based targeted drug delivery using the inner ear as a model target organ,FP6,31 October 2011,01 November 2006,1.0499957E7 NANOELECTRONOISE,University of Basel * Universität Basel,information and communications technology,"The measurements of the time dependent current fluctuations (noise) in mesoscopic devices represent a great tool to investigate electron correlations. This tool can give access to information which is not contained in usual conductance measurements, such as the effective charge of carriers or to distinguish the classical and quantum nature of chaotic scattering in cavities. It can also be used to test particle statistics. The fermionic/bosonic character leads to anti-bunching/bunching of the particles. The antibunching of the fermions is a consequence of the Pauli principle. If a fermionic beam splits into two partial ones, the fluctuations in the two partial beams are anticorrelated. A few years ago the host institute realized a fermionic analogon of the single-source Hanbury-Brown and amp;Twiss (HBT) experiment demonstrating that electrons anti-bunch as a consequence of their fermionic nature. However, bunching of electrons is possible, if for example electrons are paired in a spin singlet state, as realized in conventional superconductors. This pairing would lead to positive correlations. The goal of this project is to `search for positive current cross-correlations due to the entanglement of electrons. We will focus on correlation originated from two different types of entanglement in multiterminal semiconducting nanostructures: Spin entanglement will be studied in superconductor-normal hybrid structures; a superconducting (Nb) electrode will be used as an emitter of correlated electron pairs into a Y-shaped beam splitter constructed in 2-dimensional electron gas (2DEG). Entanglement based on the orbital degree of freedom will be probed in a two-source HBT-interferometer, which will be fabricated in 2DEG operating in the quantum Hall regime. These experiments help to understand and control the entangled mobile electrons which is fundamental for the new field of quantum computation and communication in solid state environment.",Exploring entanglement by noise measurements in nanoelectronic devices,FP6,31 December 2008,01 January 2007,184022.0 NANOELECTROPHOTONICS,Lancaster University,photonics,"The last decade has witnessed unprecedented developments in the fabrication of nanoelectronic and nanophotonic devices and microlasers based upon quantum electronic and quantum optical effects which have no classical analogue. The combination of these properties opens up a new territory in fundamental science. This project aims to lay the theoretical foundations for the cooperative interplay of electrons and photons and the accentuation of quantum-mechanical effects in these devices. The project also addresses fundamental obstacles for the commercialisation of devices which are presently developed. Systems to be addressed are at a rapidly progressing experimental stage and encompass quantum conductors, quantum dots, mesoscopic and superconducting circuits, and micro-cavity lasers. The project adopts an interdisciplinary methodological approach which brings together mesoscopic physics, quantum-optics, quantum dynamics, and electronic correlations.",Nanoelectronics and Nanophotonics: Cooperation and Accentuation of Quantum Functionality and Lasing,FP6,31 October 2009,01 November 2005,1466083.0 NANOEMBRACE,Durham University,energy,"One dimensional nanostructures (1DNS) produced from various elemental (Si and Ge) and compound (III-V and II-VI) semiconductors are receiving increasing worldwide attention due to their unique properties and potential for a wide range of applications. They are the building blocks for single photon emitters, third generation solar cells and the monolithic integration of optoelectronic devices. 1DNS can be used to fabricate the smallest light emitting devices and lasers. Despite recent progress, many fundamental and applied challenges still prevent transfer of 1DNS from laboratories to large scale industrial use. The proposed NanoEmbrace assembles eight leading industry partners and ten internationally renowned institutions in materials science, engineering, chemistry, condensed matter physics and nanoscale device fabrication. The original vision of NanoEmbrace is to gain superior control and understanding of 1DNS and to transfer 1DNS from laboratory to industry. It is probably the first organised attempt to put together all the competences and capabilities, experimental and theoretical, necessary for the comprehension of the mechanisms that govern the growth of 1DNS that cannot all be described by existing models. We also aim to provide the highest quality multidisciplinary and cross-sectoral training to early career researchers (ESRs) in nanoscience to create the next generation of research and industry leaders. The ESRs joining NanoEmbrace will have a unique opportunity to enjoy close personal contact with internationally renowned experts and to put together an unprecedented, complex but unified overall understanding of the growth of 1DNS and to develop the process required to produce practical commercial devices. To deliver the highest quality of training to young talented researchers, NanoEmbrace has identified the key research themes: controlled synthesis, theoretical modelling, characterisation of 1DNS and the integration of 1DNS into device fabrication.",Embracing One Dimensional Semiconductor Nanostructures,FP7,31 December 2016,01 January 2013,3477799.0 NANOENABLEDPV,NWO - FOUNDATION FOR FUNDAMENTAL RESEARCH ON MATTER (FOM),energy,"The 'NanoEnabledPV' research program will exploit the fundamental benefits of nanomaterials and address their challenges to make low-cost solar cells a reality. NanoEnabledPV contains three focus areas necessary to reach our goal: 1) 'Nano surface doping' -surface-controlled nanomaterial properties. We will explore using charged surface oxides and surface ligands with dipole moments as a novel doping mechanism. We will make the first nanowire solar cell using a surface 'p-n' junction. The lessons learned from single nanowire studies will be extended to make large-scale, high efficiency metal-insulator-semiconductor solar cells. 2) 'Solar highways' -metal nanowire core-semiconductor shell photovoltaics. We will examine the optical and electrical properties of silver and copper nanowires coated with various semiconductor shells for the first time. This novel device structure can achieve complete absorption using 10 times thinner semiconductor layers compared to standard thin-film structures and also enables facile charge extraction via the metal core. 3) 'Nanophotography' -hierarchical synthesis and assembly based on optical resonances in nanostructures. We will develop a new type of mask-free photolithography in solution with resolution far below the diffraction limit. This will enable rational, large-scale synthesis of ordered hierarchical structures that can be assembled into complex 3-D networks. Together, these programs that sit at the intersection of physics, chemistry, materials science and engineering will provide the active light-absorbing materials needed for next generation solar energy conversion schemes, a deep understanding of how they work at the nanoscale and methods for integrating them into macroscale devices. We are requesting 1.5 Million Euros over a period of 5 years that will be used to hire 2 PhD students, 2 postdoctoral researchers and buy the equipment needed to build a unique nanowire solar cell fabrication and analysis lab.",Novel Photovoltaics Enabled by Nanoscience,FP7,31 July 2018,01 August 2013,1499310.0 NANOEP,Technische Universiteit Delft * Delft University of Technology,health,"Electroporation or electropermeabilization is the electrical disruption of a cell's membrane to introduce foreign DNA, RNAs, drugs, proteins, or other therapies into the living cells. This technique is one of the most popular non-viral gene transfer methods for both in vitro and in vivo application. However, this method is suffering from several limitations such as: i) low transfection efficiency, ii) poor cell viability, and iii) random uptake. Multiple applications of electroporation in biotechnology and medicine rely on trial and error optimization of treatment conditions rather than knowledge of pores, dynamics and electrotransfer of DNA, due to the limited spatial and temporal resolution of traditional tools. More interesting, the phenomena behind electro-mediated membrane permeabilization to plasmid DNA (~4.5 kbp) have been shown to be significantly more complex than those for small molecules. Therefore, successful DNA electrotransfer into cells depends not only on cell permeabilization (or poration) but also on the way plasmid DNA interacts with the membrane and, once into the cell, migrates toward the nuclei. The main aim of this proposal to understand and control the transport of DNA in electroporation treatment such that stable, safe and efficient gene transfection can be achieved. Here I will use single molecule techniques (such as AFM, FRET, confocal and optical tweerers) with high spatio-temporal resolution to investigate the process of electroporation at different length (from bulk to micro/nano) and time scale (ranging from micro-seconds to hours). In addition, these unique tools will be integrated with novel micro/nanofluidics to investigate the electroporation and electrokinetic flow of DNA at micro/nano-scale. I will observe all the processes in real time with unprecedented details and quantitatively examine the kinetics of pore formation/resealing and cytoplasmic trafficking of DNA.",Single Cell Electroporation and DNA dynamics: from bulk to micro/nanofluidics,FP7,31 March 2017,01 April 2013,100000.0 NANOEYE,Cranfield University,health,"This project intends to construct novel nanosized optical fiber-based biosensors which could be applied to detect and monitor the existing telomerase in nucleus of single living cells without significantly altering and/or destructing single cell's intracellular architecture and physiological function. By studying the level of telomerase in single living cells, early-stage cancer could be detected and diagnosed. This project further aims to develop novel strategies for silver coating and biomolecules immobilisation on optical fiber-based nanoprobes.",Optical Fiber-based Nanobiosensors for Early Prostate Cancer Diagnosis,FP7,12 September 2012,13 September 2010,240289.0 NANOFAB4CNT,Technische Universiteit Eindhoven * Eindhoven University of Technology,manufacturing,"This research program aims at pioneering and developing new nanofabrication techniques for carbon-nanoelectronics using a so-called 'bottom-up' approach. Individual building blocks for carbon-based nanodevices, such as catalyst nanoparticles, horizontally aligned carbon-nanotubes and ultra-scaled contacts and dielectrics will be precisely placed directly on the chip, without the use of lithography. This will be accomplished by using unique combinations of electron-beam induced deposition (EBID), atomic layer deposition (ALD) and oblique ion beam treatments. The process development will go hand-in-hand with atomic level understanding of the developed processes using in-situ and ex-situ analysis techniques to ensure process reproducibility and selectivity.",Novel bottom-up nanofabrication techniques for future carbon-nanoelectronics,FP7,07 July 2018,08 January 2012,0.0 NANOFACT,Athlone Institute of Technology,health,"Bone has a remarkable capacity to heal. However, in some instances the amount of bone which is needed to heal exceeds its healing capacity. These cases arise following accidents, infection or surgery to remove cancerous tissue and they result in the need to perform approximately 600,000 surgical bone grafting procedures annually. These procedures have inherent disadvantages and so there is an urgent clinical need to develop a tissue engineering alternative to bone grafting. In this study an osteoconductive/osteoinductive nanoscaffold will be designed to retain growth factors with proven osteogenic potential within their structure. As such, relatively low doses of these expensive molecules can be retained at the bone defect site. The technology developed in this study has enormous potential to reduce the overall burden placed on patients and on European healthcare systems by reducing the costs involved in using Growth Factors in a variety of applications. To perform this work the Fellow will move from Athlone Institute of Technology, Ireland to join a leading orthopaedic research group at one of Harvard University's teaching hospitals where he will be trained in nanotoxicity testing, detection of growth factor release, cell loading and orthopaedic preclinical models. The Fellow has extensive knowledge in the field of biomaterials and orthopaedic research having trained at the AO Research Institute, Davos, Switzerland. However this fellowship will allow him to develop his knowledge in the field of biocompatibility testing. Knowledge developed in this area will be transferred back to Europe during the return phase of the fellowship. This knowledge will allow the Fellow to further refine the research carried out at Harvard. The goal of this research is to develop translational solutions to clinical problems. Indeed, the chance to work at Harvard would be hugely beneficial in developing direct links to clinicians at one of the world's most prestigious Universities.",DEVELOPMENT OF BIOACTIVE NANOCOMPOSITES FOR BONE TISSUE ENGINEERING APPLICATIONS,FP7,31 May 2015,01 June 2012,371166.0 NANOFATE,Natural Environment Research Council,environment,"Concept: NanoFATE has been conceived to fill knowledge and methodological gaps currently impeding sound assessment of environmental risks posed by engineered nanoparticles (ENPs). Our vision is to assess environmental fate and risk of ENPs from high-volume products for which recycling is not an option; namely; fuel additive, personal care and antibacterial products. Two market ENPs from each product (CeO2, ZnO, Ag of varying size, surface and core chemistries) will be followed through their post-production life cycles i.e. from environmental entry as “spent product”, through waste treatment to their final fates and potential toxic effects. This will test the applicability of current fate and risk assessment methods and identify improvements required for a scientific assessment of ENPs at an early stage. Objectives: Such systematic study of the environmental fate and toxicity of selected ENPs will entail addressing 9 S&T objectives: 1: Design, tagging and manufacture of ENPs 2: Analysis of ENP interactions with abiotic and biotic entities 3: Generating predictive models for ENP exposure in waters and sludge-amended soils 4: Studying the fate and behaviour of ENPs through wastewater treatment 5: Determining acute and chronic ecotoxicity 6: Assessing effects of physico-chemical properties on ENP bioavailability 7: Defining mechanisms of uptake, internal trafficking, and toxicity 8: Developing spatial RA model(s) 9: Improving understanding of ENP risks Methodology: The work plan is designed to progress beyond the state-of-the-art through focused workpackages. While some objectives are delivered in single WPs, good cross WP integration will secure the key objectives of delivering new methods for quantifying ENP risks. Impact: NanoFATE will provide robust tools, techniques and knowledge needed by stakeholders to understand and communicate risks associated with different ENPs, including their environmental interactions and toxicity.",Nanoparticle Fate Assessment and Toxicity in the Environment,FP7,03 July 2016,04 January 2010,2497100.0 NANOFEN,University of Cambridge,information and communications technology,"The study and development of novel functional materials are critical to the development of future device technologies. At the mesoscopic scale, new physics can be realised, which is highly relevant for the future generation of nano-electronic devices and thus is of considerable industrial importance. Hence, the enabling factor for study of functional materials is the ability to process different forms of the materials on different scales, as well as to interface them on the nano-scale.NanoFen (Novel Nano-scale Multifunctional Materials Engineering) is a project which involves novel materials processing, the growth of functional nano-wires, the exploration of routes for ordered nano-wire growth, the production of multifunctional nano-composites, and the demonstration of simple, novel (multi)functional devices. In order to transform the promises of the nano-scale phenomenon into industrial applications, practical approaches will be adopted, and hence there will be an emphasis on chemically based processing routes. There will also be a particular emphasis on the study of oxide materials which display almost all of the solid state functions from high K dielectrics to superconductors. The NanoFen Excellence Team will be trained to a high level in the areas of materials engineering, nano-technology, microstructural characterisation, a broad range of processing methodologies, and device materials. In summary, the main objectives of NanoFen are to:1. Develop novel processing technologies for growth of nano-structured functional materials2. Apply an intelligent combinatorial approach to realising nano-composite architectures3. Demonstrate simple, novel (multi)functional devices",Novel Nano-scale Multifunctional Materials Engineering,FP6,31 May 2009,01 June 2005,1353157.0 NANOFERRO,Poznan University of Technology * Politechnika Poznańska,manufacturing,"Nanotechnology is expected to have a big impact on most of our life. Nanostructred materials become more and more important in various fields such as nanoelectronics, information storage technology etc. At the nanometer scale, i.e. 1-100 nm, material properties are clearly size dependent and new properties are expected. Among functional materials nanoscale ferroelectrics can have a major role because they can be applied in different fields such as sensors, actuators, memory devices and optics. However they cannot be applied to nanometer scale devices before the influence of the lateral size on physical properties will be clarified.In order to find answer for the problems there is a need to have good quality nanoscale structures. It is a challenge to fabricate such structures in this range using both lithography (¿top¿down¿ approach) and self-assembling and self-patterning methods (¿bottom¿up¿ approach). Whereas conventional lithographic systems work usually with a resolution of about 100 nm the bottom-up approaches allow the inexpensive fabrication of structures with size of 10-20 nm. The main goal of the work is preparation of nanosized ferroelectric crystals by self-assembling methods. Successful strategies and routes have been developed to synthesize nanoscale materials of numerous simple systems such as semiconductors or metals. Complex systems such as ferroelectric oxides are not yet systematically addressed, despite of the possibility of discovering new materials with unique properties. Physical route based on the concept of microstructural instability of ultrathin films and chemical routes will be applied to obtain different perovskite crystals. A good quality of nanostructures that lateral dimension can be tuned in nanometer range is expected to fabricate and in future this will allow investigating structure-property relations (e.g. by transmission electron microscopy and piezoresponse force microscopy) and solve ¿size effects¿ problem.",Towards size effects in nanosized ferroelectrics - fabrication of nanocrystals by self-assembling methods,FP6,,,40000.0 NANOFERROELECTRICS,University of Cambridge,information and communications technology,"The increasing demand for size reduction in ferroelectric devices is faced with both technical andfundamental problems at the nanoscale level.Among the technical challenges, one of the main areas of research is, as ever, how to store more chargeper unit area in a cost and time-effective manner. Regular arrays of ferroelectric nanotubes offer aninteresting possibility in this respect, as a high storage density can be achieved through a high aspectratio of the nanotube-based cylindric capacitors. In addition, such nanotubes also have potential uses inthe field of microelectronic actuators (MEMS). However, due to the technical difficulty in applyingelectrodes and making electrical contacts in such structures, the functional properties of the nanotubeshave not yet been tested. This will be one of the priorities of the present project.On the other hand, planar-like geometries are easier to manufacture, which is why the are usually thepreferred shape for both fundamental research and industrial applications. Even then, patterning ofregular arrays at the nanoscale level is not trivial. In this respect, an appealing alternative to the usuallithography method is the idea of self-patterning of ferroelectric nanostructures. We will explore this bythe use of some ideas borrowed from the field of semiconductor quantum dots.Finally, any project concerned with miniaturisation in ferroelectrics must face the fundamental problemof the 'si/e effect', i.e., the decreasing of the dielectric constant of ferroelectric thin films with respectto their bulk counterparts. One of the causes of this seems to be the accumulation of space charge at theinterface between electrode and dielectric. In order to minimise this charge it is necessary to know indetail the band structure of the metal and the dielectric. Such knowledge must include the energy levelscorresponding to impurities and deep traps in the bandgap of the ferroelectric. In or#","NANOSIZE FERROELECTRICS: FERROELECTRIC NANOTUBES, SELF-PATTERNING AND SIZE EFFECT MINIMISATION",FP6,31 August 2007,01 September 2005,168799.0 NANOFIRE,Culture Center for Plastic Materials Engineering * Centro di Cultura per l'Ingegneria delle Materie Plastiche,environment,"Flammability is a major limiting factor for the expansion of polymer materials. The potential contribution of polymer materials to development of technologies with reduced environmental impact, may thus be missed. Fire retardant approaches developed in the past can no longer be used owing to undesirable side effects during fire retardance action and hindrance to end of life recycling technologies. Worldwide research in this area has not yet provided a suitable solution in terms of simultaneous fire risk and fire hazard reduction. However, new classes of nanocomposite materials and inorganic-organic hybrids can be rendered inherently fire retardant if their decomposition behavior is catalytically directed towards ceramisation and charring with creation of a surface protection to the polymer material. Particularly interesting in this approach are polyhedralsilsesquioxanes (POSS), carbon nanotubes (CNTs), and needle-like silicates with which the project deals. The success in implementing the ceramisatìon-charring mechanism, requires a combination of expertise encompassing deep knowledge in polymer chemistry and engineering, polymer thermal degradation and combustion, inorganic and physical chemistry and catalysis that could assist in performing a great breakthrough in an area that is of vital importance to our technological development. The partners of the Consortium proposing the project cover all these areas at a highly qualified level which is necessary to produce the substantial progress in basic knowledge on the fiammability of polymer nanocomposites and hybrids required to create an environmentally friendly highly performing new approach in fire retardance. Beside fire retardance, the inorganic nanophases are suitable carriers for distributing functional molecules in the polymer matrix that can lead to multifunctional materials with a whole range of applications such as transport, electrical and electronic sector, building, furniture, clothing, etc.",Environmentally friendly multifunctional fire retardant polymer hybrids and nanocomposites,FP6,31 August 2007,01 September 2004,2290000.0 NANOFLEX,Norske Rørleggerbedrifters Landsforening Vvs,environment,"The building and construction community in Europe includes about 150000 plumbing, heating, ventilation, air conditioning contractor SMEs with 1.2 million employees generating a total turnover of €130Bn. Our community faces the challenges of meeting the growing demand for plastic pipes and the EU Landfill Directive and the revised EU Waste Framework Directive. The polluter-pays principle says that the costs of waste management are to be borne partly or wholly by the producer of the product from which the waste came and the distributors of such products, who are our SME members. Under floor heating, radiator heating and plumbing systems accounting in total 1.7 million kilometres of new piping in Europe, of which 56%, namely 0.96 million km are plastic pipes. 46% of these plastic pipes are made of PEX, which due to its cross-linked nature is not recyclable. Recycling of multilayer pipes with encapsulated aluminium results in highly toxic by-products. About 3500 tonnes of scrap plastic pipes is disposed of in land fill due to the use of non-recyclable plastics.",An Universal Flexible Low-cost Plumbing and Heating pipe system fully Environment-compatible by using innovative Nanoparticle technology,FP7,10 July 2015,11 January 2010,0.0 NANOFLOC,Westmatic i Arvika AB,environment,"The rapid introduction of nano-based products into the market has caused a major concern both for health and environmental impacts, among others from the paint and coating business. A number of studies have documented health risks related to nanoparticles, inhalation exposure and dermal contact being main exposure routes in the coating and paint industry. Likewise, discharge of nanoparticles into aquatic environment causes damage to the gill membrane of fish and crustaceans. Today, the only effective means of removing nano-particles from water is application of energy intensive methods such as reverse osmosis. Therefore, the coating industry that uses products with nanoparticles needs a cost effective technology for removing them from used water.",Electro-agglomeration and separation of Engineered NanoParticles from process and waste water in the coating industry to minimise health and environmental risks,FP7,12 July 2016,01 January 2013,0.0 NANOFLUIDIC-SMFD,Wageningen University,health,"Currently, the two prominent schemes for single-molecule fluorescence detection (SMFD), confocal microscopy and camera-based total-internal-reflection or wide-field microscopy, are ultimately limited in their ability to combine the detection of many molecules with obtaining data at sufficiently high time resolution, necessary for resolving fast dynamics with single-molecule fluorescence resonance energy transfer (smFRET). In particular, monitoring enzymatic reactions using smFRET is extremely challenging and remains to a large extent unexplored. Here, I propose a novel nanofluidic device to overcome these limitations by using nanochannels, which provide a well-defined flow path for a fluorescent species through the excitation/detection focus of a conventional wide-field microscope. Using an array of nanochannels offers several advantages: First, the geometrical confinement enables long observation times of non-immobilized molecules. Second, the residence time of molecules in the channels is easily controlled by the flow velocity set by the syringe pump. Third, faster flow rates together with using a CCD camera in 'streaking mode' enable a sub-millisecond time resolution. Fourth, a high-throughput detection is achieved by using a parallel array of channels. Fifth, enzymatic reactions can be directly triggered by mixing necessary components on-the-fly using an additional inlet. The described device will pave the way for high-throughput single-molecule detection, which will greatly expand the possibilities for researchers to apply single-molecule methods in the area of Life Sciences.",Nanofluidic devices for high-throughput single-molecule-fluorescence detection,FP7,28 February 2018,01 March 2014,100000.0 NANOFOL,University of Minho * Universidade do Minho,health,"NANOFOL proposes to develop a new diagnostic/therapy approach using folate based nanobiodevices (FBN) able to provide a new type of cost efficient treatment for chronic inflammatory diseases such as Atherosclerosis and Rheumatoid Arthritis with low side effects that will constitute a more advantageous solution than current therapies. NANOFOL will achieve all that by fulfilling the following objectives: •Design , development and production of nanobiodevices (FBN) targeting directly effector cells •Proof of concept in vitro and in vivo of a folate based nanodevice targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept in vitro and in vivo of a nanodevice containing a bispecific antibody (against folate receptor and another macrophage marker) targeting activated macrophages in chronic inflammation not affecting bystander cells •Proof of concept of FBN delivery therapeutic agents (by small interfering ribonucleic acid molecules (siRNA) or lipophylic molecules) targeting inflammatory signaling pathways •In vitro and in vivo testing of cellular toxicity caused by the novel nanobiodevices in cells other than activated macrophages •Design of models that will enable to minimize animal experimentation. •Development of a strategy to assess potential risks in order to ensure nanobiodevice safe delivery. NANOFOL has adopted a specific risk strategy to attain objectives in a step by step approach allowing improving gradually the concept (specificity, stability, side effects efficacy) from the lower to the higher risky solutions ensuring reduced experimental animal testing and high human safety. The NANOFOL project will combine expertise in nanotechnologies, biology, chemistry, materials science, biotechnology, engineering, risk analysis, medical and pharmaceutical sciences.",Folate-based nanobiodevices for integrated diagnosis/therapy targeting chronic inflammatory diseases,FP7,30 November 2013,01 December 2009,5149874.0 NANOFOODS,University of Naples Federico II * Università degli Studi di Napoli Federico II,health,"The preservation of bioactive food ingredients through product processing and storage, and their controlled release in the gastrointestinal tract is yet a major obstacle for the full exploitation of the health potential of many food bioactive components. In addition, conventional microencapsulation solutions often affect the textural sensory properties of the food. The overall objective of the NANOFOOD project is to develop and the validate the efficacy of a new generation of healthy foods based on nanocapsules technology. Tailored nanocapsules able to deliver omega-3 fatty acid and silymarin complex into the lower gut will be designed and produced by a specialized Israeli SME in collaboration with Technion, Haifa. These nanocapsules will be incorporated as bioactive ingredients into dry pasta by an Italian SME and into typical bread products by a Turkish SME. The development and characterization of these products will be supported by food scientists operating in leading research centres. Finally, the efficacy of the developed food products will be assessed by a human clinical trials on patients affected by Intestinal Bowel Disease, where the anti-inflammatory properties of the selected ingredients could be highly beneficial. NANOFOODS project will provide SMEs of the consortium with necessary tools and know-how to introduce in the EU markets foods based on nanoencapsulated bioactive ingredients according to the new European legislation regarding novel healthy foods marketing.",Development of foods containing nanoencapsulated ingredient,FP7,30 November 2010,01 October 2008,726000.0 NANOFOOT,Curtumes Aveneda Lda,health,"NANOFOOT main goal is to develop advanced and innovative nanotechnology based solutions for leathers and polymers components for footwear products, aiming a new sustainable and customer-driven production of consumer goods; where the health, environment, high quality of components, fair marketing communication and competitive sales price are combined to promote the competitiveness of the companies. NANOFOOT SMEs have the ambition of exploring the potentialities and the benefits of nanoparticles (NPs) available in the market on the development of new functional materials & products. The final objective is to get differentiated, high added value and marketable materials and footwear consumer goods; that satisfy the needs and expectations of the final consumers. The consortium is constituted by 9 members (5 SMEs and 4 RTD institutions). A balanced and interdisciplinary team is formed by combining the know-how of SMEs with the expertise of the University and Technology Research Centres. The consortium will provide an effective way to develop and transfer knowledge to the companies, a requisite needed to promote innovation and the results commercial exploitation. NANOFOOT RTD and technical activities include: Screening of commercially available cost-effective nanoparticles; • Investigation of the functionalization of processing products, coatings and leathers using nanoparticles. • Investigation and development of polymeric nanocomposites and footwear components. • Develop advanced antimicrobial thermal auto-regulated footwear. • Develop an integrated environmental approach to safeguard consumers, workers, workplace and environmental. • Perform prototype demonstrators and dissemination actions. • Prepare results exploitation by the SMEs and IPR protection.","Materials, Components and Footwear with enhanced comfort properties based on nanotechnologies",FP7,31 August 2015,01 September 2013,622000.0 NANOFORART,Consorzio per lo Sviluppo dei Sistemi a Grande Interfase,environment,The main objective of the NANOFORART proposal is the development and experimentation of new nano-materials and responsive systems for the conservation and preservation of movable and immovable artworks.,Nano-materials for the conservation and preservation of movable and immovable artworks,FP7,11 June 2016,12 January 2011,0.0 NANOFORBIO,Technische Universiteit Delft * Delft University of Technology,health,"I propose to employ our advanced capabilities for nanofabrication to explore new biology at the single-molecule and single-cell level. I choose to specifically address two directions of intense scientific interest: (i) With my team I will develop and exploit solid-state nanopores for the study of real-time translocation of individual biomolecules. In the past few years, my group has attained a leading position in this field and we want to apply our advanced knowledge to push the technology and use it to resolve some pressing questions in cell biology and biotechnology. Specifically, we will explore screening of DNA-protein complexes at the single-molecule level, and we will build biomimetic nanopores to address the physical mechanism of selection and controlled molecular transport of the nuclear pore complex. (ii) We will use nanofabrication to create well-defined landscapes for bacteria. This will allow biophysical studies of the interaction between bacteria and their habitat with an unprecedented control of the spatial structure and habitat parameters. I strongly believe that this approach constitutes a major new tool to experimentally address a number of fundamental issues in the ecology and evolution of bacteria for the first time in a controlled environment. Additionally, it opens up a way to explore the biophysics of bacteria in confined space, where we will study a new bacterial phenotype in nanofabricated slits which we recently discovered. While this research is primarily driven by the quest for understanding physical mechanisms in biology, it can also be expected to have profound impact on applications in antibiotics, gene therapy, and DNA sequencing.",Nanostructures for biology,FP7,28 February 2015,01 March 2010,2499091.0 NANOFORCELLS,Consejo Superior De Investigaciones Científicas (CSIC),health,"The fact that biophysical and biomechanical properties of cells and subcellular structure influence and are influenced by onset and progression of human diseases is now attracting the physiologists attention. This opens up new routes for disease diagnosis and treatment. The first traditional way to discover a tumor was by palpation, such as sweetness in urine was indicative of diabetes. Nowadays, the biochemical search for diagnosis markers has experienced amazing advancements, while the physical cues have remained almost forgotten; this is mainly due to a lack of powerful tools able to unravel the mechanics of individual cells. This proposal aims to develop a set of tools and demonstrate their potential for the throughout study of individual cell mechanics and sub-cellular structures. The proposed tools will provide the route to develop mechanical and physical assays to extract the elastic and viscoelastic deformability of f.e. cancer cells as compared to healthy cells, providing with mechanical biomarkers for diagnosis. NANOFORCELLS proposes an innovative approach combining optical interferometry together with advanced nanomechanical systems and AFM local characterization. This mechanical lab for cells will provide new knowledge that can not be attained today with present technologies. Also, the proposed nanomechanical devices of this project will provide not only a direct measurement for single cell rigidity but the capability for parallel measurement of hundreds of individual cells per minute, opening the route for portable tests that could prove very general to determine the health status of cells from blood samples. Also, interaction of cell with the environment can be studied in real time and thus the devices will provide tools for the study of drug effects and drug delivery vehicles, or for the assessment of the toxicity of nanoparticles.",Development of a nanomechanical tool-box for the investigation of cell mechanics,FP7,31 October 2016,01 November 2011,1492854.0 NANOFUN-POLY,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),photonics,"The main objective of NANOFUN-POLY is to generate a Network of Excellence designed to become the European reference point on Multifunctional Nanostructured Polymers and Nanocomposite Materials. This objective will be reached through a trans-disciplinary partnership of 150 scientists combining excellence in different scientific areas, where the synergy of international excellence and multidisciplinary approaches will lead to develop and spread knowledge in innovative functional and structural polymer-based nanomaterials and their sustainable technologies. Applications that will benefit from NANOFUN-POLY concern strategic industrial sectors which can be competitive only by using advanced technologies: optoelectronics and telecommunications, packaging, agriculture, building construction, automotive and aerospace, etc. Europe can now develop an integrated approach from macromolecular and supramolecular chemistry to tailored design and advanced processing methods for polymer-based nanostructured polymers and nanocomposites. The integration of a critical mass of resources and expertise to provide European leadership, will be realized by different integrated networking activities; the main one being a joint programme of activities, by creating a progressive and enduring integration of the research capacities of the network while at the same time developing advanced knowledge. The network will include partners outside Europe to help in spreading excellence and at the same time obtain access to knowledge not necessary available in our region. Training, communication, dissemination and transfer of knowledge and technologies developed inside the Network will also be essential components of the joint programme of activities. The final objective is to create a lasting integrated community of researchers at a European level, well connected with the rest of the world and able to lead research, education and technology transfer in nanostructured",NANOSTRUCTURED AND FUNCTIONAL POLYMER-BASED MATERIALS AND NANOCOMPOSITES,FP6,31 May 2008,01 June 2004,6600000.0 NANOFUNCTION,Grenoble Institute of Technology * Institut polytechnique de Grenoble,information and communications technology,,Beyond CMOS Nanodevices for Adding Functionalities,FP7,08 July 2015,09 January 2010,0.0 NANOGEND,Queen Mary University of London,health,"The scientific aim of this project is to develop and characterize a selected set of novel intelligent nanogels, designed to be able to cross the Stratum Corneum of the skin, and to study their suitability as drug delivery systems in inflammatory skin diseases. Ultrasmall nanogels will be synthesized using high dilution radical polymerization, a technique well established in the host's laboratory, which allows the control of the particle size and polydispersity. Three different groups of nanogels will be prepared: 1) fluorescent nanogels 2) molecular imprinting nanogels 3) thermoresponsive nanogels. The first group will be used to study the distribution and localization of nanogels in normal human skin model reproduced in vitro by organotype cell co-culture. The second group will be used to evaluate the molecular imprinting approach as a tool to obtain very selective delivery system with high recognition characteristics. This has not been studied before and will provide a unique approach, when coupled with high permeation characteristics. The last group, the thermoresponsive nanogels, will combine good permeation with ability to release the drug following a change in temperature and will be compared with more traditional systems. The project will explore the use of each nanogels set to complex and deliver (a) small anti-inflammatory drugs, and (b) large molecules, in particular siRNA, given the strong expertise of the applicant in this area and the emerging interest for these new therapeutics in topical administration. Penetration and pharmacological effects of the drug-nanogels complexes will be assessed in pathological skin in vitro model by the improvement of the disease phenotype. The most significant novelty of the project will be the development of new organic polymeric nanogels able to cross the SC of the skin, providing a new non-invasive gene delivery technology system, that could bring very important applications in dermathology as well as in other fields.",Novel Thermoresponsive Organic Nanogels for Topical Gene Delivery of RNA-Based Drugs,FP7,07 October 2014,01 July 2012,209033.0 NANOGENE,University of Lodz * Uniwersytet Łódzki,health,"Dendrimers are a new class of nanomaterials. They are monodisperse, stable, and are characterized by relatively low viscosity at high molecular mass and numerous end groups that can be ionized, which means that they can efficiently bind a large amount of genetic material and deliver it to ill organs and tissues (gene therapy). The partners of project from EU countries organized European research network in the field of dendrimers. They collaborate in the frames of EU Framework 7 Programme supported grants and initiatives: COST, MNT ERA NET 2007, ERA NET EuroNanoMed 2010. Belarus and Russia partners started to collaborate in the field of multifunctional dendrimer/carbon nanotubes as gene carriers on the basis of bilateral collaboration grant. Present project is devoted to combining of these two independent networks in one EU-Belarus-Russia platform in the field of nanomaterials for biomedical applications. The main objective of NANOGENE project is to provide the tight collaboration of six institutions from European Union, Russia and Belarus in the field of nanomaterials-driven delivery of anti-cancer siRNA into cancer cells. The aims to be achieved are: I: Encouragement and promotion of the international collaboration (trainings, promoting and facilitating the international collaboration relevant to FP8); II: International networking and strengthening of the research collaboration (workshops, strengthening the research management and scientific links existing among participating university/academia partners and distribution of best practice in FP8 project administration); III: scientific results realized in the number of papers in peer-reviewed journals and presentation of joint results at conferences. Such international co-operation is important for building linkages between EU countries and Belarus and Russia for creating better relations between institutions which results in more united Europe and for future joint FP8 proposals.",EU-Belarus-Russia Network in Nanomaterials-Driven Anti-Cancer Gene Therapy,FP7,31 December 2016,01 January 2013,387600.0 NANOGNOSTICS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"6.1 million people currently live with a form of dementia in the European Union with an addition of 1.4 million new cases every year. Combination of psychological testing, brain-imaging and exclusion of other neurological disorders makes the diagnosis of Alzheimer's disease complicated and time consuming (taking up to 20 months). A rapid, sensitive and specific immunoassay for protein markers inside blood would largely improve early diagnosis and lead to a better treatment of dementia. Homogeneous assays based on FRET from one dye labeled specific antibody (AB1) to another (AB2) within an 'AB1-biomarker-AB2' immune complex are an ideal basis to meet these diagnostic requirements. As the detection of several protein markers is obligatory for a highly sensitive and specific diagnosis an optical multiplexing approach with dyes of different colors is a smart solution. Semiconductor quantum dots (QDs) are the ideal candidates due to their size-dependent absorption and emission wavelengths. Moreover, they possess unique photophysical properties that overcome conventional fluorescence dyes. In combination with lanthanide complexes (LCs), that display long luminescence lifetimes and well separated emission bands, QDs render a powerful multiplexing tool for highly sensitive diagnostics even for large immune complexes. FRET applications using QDs are to date restricted to academic research and a profound understanding of QD-based FRET is not available. For a comprehensive analysis the use of LCs is mandatory, because they are the only known donors for efficient FRET to QD acceptors. NANOGNOSTICS strives for a profound understanding of QD-based FRET, the synthetic creation of highly efficient QD immune sensors for detection of several Alzheimer-specific protein markers and the development of a modular high-throughput-screening immuno analyzer for the integration of QD-based multiplexing immunoassays into early diagnosis for improved patient outcome in dementia therapy.",Quantum Dot-Based Highly Sensitive Immunoassays for Multiplexed Diagnostics of Alzheimer's Disease,FP7,31 March 2013,01 October 2009,4037064.0 NANOGOLD,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),photonics,"The NANOGOLD project aims at the fabrication and application of bulk electro-magnetic metamaterials. A promising new concept for the exploration of metamaterials is the use of periodic structures with periods considerably shorter than the wavelength of the operating electromagnetic radiation This concept allows to control the refractive properties. Making use of a bottom up approach in materials design, we will apply self-organization of organic-inorganic composite materials containing resonant entities. To tune electromagnetic properties, resonance and interference at different length scales will be implemented. In such a way we will obtain bulk optical metamaterials operating in spectral domains appropriate for photonics that can be used in applications. Our groundbreaking solution to form such artificial matter is interdisciplinary and combines inorganic chemistry, organic macromolecular synthesis, physics of electromagnetic resonances and liquid crystal technology. We start with resonant entities (metallic nanoparticles) and organize them via self-organization on the molecular scale. Systematic modular variation of the chemical entities gives access to libraries of materials which will be used to arrive at systems with desired properties. Simulation of optical properties and molecular ordering will guide the design of compounds and materials. Organization at molecular level leads to homogenous materials with optical, electronic or magnetic properties at elevated frequencies, in the visible and near infrared spectral range. The controlled utilization of the polymer physics of micro-segration, will allow for additional structuration at the nano-scale giving design freedoms to tune material properties optimally. NANOGOLD furthermore will make use of innovative fabrication techniques and processing known from liquid crystal displays by exploring new physical effects, which will result in novel devices.",SELF-ORGANIZED NANOMATERIALS FOR TAILORED OPTICAL AND ELECTRICAL PROPERTIES,FP7,31 July 2012,01 August 2009,3519235.0 NANOGOLD4PARKINSONS,Imperial College London,health,"Parkinson's disease (PD) is a chronic and debilitating neurodegenerative movement disorder that is set to rise in incidence with a rapidly ageing global population. As current clinical treatments offer only symptomatic control with no curative options, there is an urgent need for novel therapeutic approaches that can delay further neurodegeneration and enhance the overall quality of life in PD patients. Recent emerging evidence on the prion-like spreading neuronal accumulation of misfolded α-synuclein proteins as well as the oxidative stress induced demise of dopaminergic neurons have revealed promising molecular targets for potential disease modifying therapies. Capitalising on the facile synthesis, low cytotoxicities and unique optical properties of gold nanoparticles (AuNPs), we propose the development of two types of novel AuNPs bearing leptin-receptor targeting peptides, namely (a) leptin-poly(ethylene glycol)(PEG)-poly(ethyleneimine)(PEI)-AuNP and (b) α-synuclein inhibitor-/leptin-PEG-AuNP for the respective delivery of the Nrf-2 antioxidant gene (pNrf-2) and α-synuclein peptide inhibitor across the blood brain barrier (BBB). In this study, detailed physicochemical characterisation as well as the evaluation of the cytotoxic and inflammatory properties of the functionalised AuNPs will be studied in a panel of brain-relevant cell types. The BBB permeability of the functionalised AuNPs and pNrf-2 complexes will be evaluated in a well-characterised in vitro transwell co-culture model; with cellular localisation examined using advanced microscopic techniques. The neuroprotective effects of inhibiting α-synuclein aggregation and upregulation of Nrf-2 antioxidant proteins using the functionalised AuNPs will be examined in a dopaminergic cell line. It is envisioned that upon the successful establishment of their respective neuroprotective effects, both types of functionalised AuNPs could be simultaneously administered for maximal clinical benefits.",Targeted Brain Delivery of Nrf-2 Gene and α-Synuclein Binding Peptide using Functionalised Gold Nanoparticles for Disease-modifying Therapy of Parkinson's Disease,FP7,26 May 2016,27 May 2014,221606.0 NANOGRAPH,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),photonics,"Graphenes, single sheets of graphite, hold enormous promise as a material of the future, since their unique electronic properties might allow us to combine advantages of silicon and plastics. We propose a concept for the synthesis and processing of mono- and multilayered graphenes and of graphene nanoribbons (GNRs), which are strips of graphene exhibiting a high aspect ratio. The key idea is the dehydrogenation (and planarization) of precursor molecules made from twisted benzene rings. Size and shape of the final graphenes will be chemically determined by the precursors themselves, which can be synthesized with great perfection. This elegant level of structural control of graphenes and GNRs discriminates our approach against existing literature efforts. Defined edges of GNRs are essential for creating finite electronic band gaps, since pristine graphene is a semimetal and thus not suitable for most electronic and optoelectronic applications. Graphenes at a size of several hundred nm will be targeted in solution, but mainly after deposition and transformation of the precursor molecules on substrate surfaces. The consequence is that we will apply and combine organic polymer synthesis and processing with methods of surface physics to create a new materials science of graphenes. Further characteristics of the work will include in-situ monitoring of chemical processes by scanning probe methods and interfacing of as-formed graphenes for in-situ measurements of charge carrier mobility and spin transport. Applications will be demonstrated for the construction of batteries, fuel cells, field effect transistors, and sensors. What we expect as key achievements will be the delineation of reliable structure-property relationships and improved device performance of graphene materials.",The Chemists Way of Making and Utilizing Perfect Graphenes,FP7,31 January 2016,01 February 2011,2500000.0 NANOGRAPH@LSI,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"Graphene is a new class of promising material with exceptional properties and thus warrants a plethora of potential applications in various domains of science and technology. However, due to intrinsic zero bandgap and inherently low solubility, a prerequisite for the use of graphene in several applications is its controlled and reproducible functionalization in a nanostructured fashion. Being a ‘surface-only’ nanomaterial, its properties are extremely sensitive not only to chemical modification but also to noncovalent interactions with simple organic molecules. A systematic knowledge base for targeted functionalization of graphene still eludes the scientific community. The present experimental protocols suffer from important shortcomings. Firstly, graphene functionalization occurs randomly in solution based methods and there is scarcity of methods that can exert precise control over how and where the reactions/interactions occur. Secondly, due to random functionalization, producing reproducible samples of structurally uniform graphene and graphitic materials remains a major challenge. Lastly, a molecular level understanding of the functionalization process is still lacking which precludes systematic strategies for manipulation of graphene and graphitic materials.",Nanostructuring graphene and graphitic substrates for controlled and reproducible functionalization,FP7,10 July 2020,11 January 2013,0.0 NANOGROW,Queen's University Belfast,health,"This proposal will establish a program of research at Queen's University Belfast that will pursue a strategy for mimicking the bottom-up nature of biological growth to produce bulk, macro-scale materials that exhibit some of the salient features and advantageous properties observed in bone, teeth, shells, and deep-sea glass sponges. Layer-by-layer assembly of nanocomposite coatings onto porous, three-dimensional substrates will result in materials with uniquely customizable stiffness & porosity, and an exceptionally high upper bound on strength and stiffness as functions of density. These materials will be developed and characterized as tissue-scaffold materials for biomedical applications, and core materials in sandwich structures for lightweight structural applications. This bottom-up approach will enable exciting bio-inspired concepts for incorporating multifunctionality and improving mechanical performance. For example, implementing a nanocomposite coating with a deposition rate that can be controlled by the magnitude of the local mechanical deformation, will result in a growth process that is directed by external loads -- mimetic of bone growth and adaptation according to Wolff's law. The materials resulting from this project have the potential for significant economic impact by reducing fuel consumption and increasing energy output, and to contribute solutions to societal challenges related to health and energy/resources. The project will be led by an early-career researcher with strong academic credentials, a history of successful collaborations and high-impact publications, and a network of close professional contacts in Europe and North America. Supporting this work will establish an internationally mobile researcher in the European Research Area, promote collaboration and resource-sharing across national borders, and advance the key enabling technologies recommended by the European Commission for economic growth and resolution of societal challenges.",Growing Synthetic Load-Bearing Materials: Nano-Scale Fabrication of Bio-Inspired Materials for Marco-Scale Structural and Biomedical Applications,FP7,28 February 2018,01 March 2014,100000.0 NANOHAND,Kuratorium OFFIS eV,information and communications technology,"In the NanoHand project a system consisting of micro/nano based subsystems for automatic handling of nanometer sized objects like carbon nanotubes (CNTs) and nanowires (NWs) will be developed. The goals of the project are driven by the needs of upcoming semiconductor technology. Two demonstrators will be built, which have a short term (a) as well as a long term (b) perspective: (a) automated decoration of scanning electron microscope (SPM) probes with (i) supertips grown by focused electron beam induced deposition and (ii) CNT-enabled supertips; (b) handling and assembly of CNTs for the construction of nanoelectronic devices. The cornerstones of the NanoHand project are the many results of the FP5 GROWTH project ROBOSEM (Development of a Smart Nanorobot for Sensor-based Handling in a Scanning Electron Microscope) which was successfully finished in 2005. In this project the technological basis for microrobotics was developed and demonstrated. The goals of NanoHand go far beyond. The new possibilities due to the microrobotic techniques will be demonstrated in two industrially highly relevant applications mentioned above. The project¿s consortium gives almost a guarantee for the projects success, it consists of a number of Europe¿s most experienced research institutes in the filed of microrobotics and nanohandling, the biggest semiconductor company in Europe, and a number of dynamic SMEs in the field of nanotechnology. Moreover, the exploitation of the project results will be done most effectively by the biggest Europe-wide network of SMEs in the field of microsystems technology.",Micro-nano system for automatic handling of nano-objects,FP6,31 May 2009,31 May 2006,4930000.04 NANOHAP,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,manufacturing,"Photocatalysis is a potential tool for environmental and effluent water cleaning. Large band gap semiconductors, first of all TiO2, are commonly employed as photocatalysts. However, most of the photocatalytic materials possess band-gaps corresponding to the Ultra-Violet (UV) wavelengths (220-380 nm) and suffer from low efficiencies due to the high degree of recombination between the photogenerated charges carriers. The challenge is to develop a material with optical band gap in the visible wavelength of the sun’s spectrum (400 nm – 900 nm) and with a suitable flat band potential for efficient charge transfer across the interface. In addition, for many applications it is essential to use photocatalytically active materials in the form of thin films. The proposed work aims at developing a new thin film photocatalytic material to work at visible wavelengths of sun’s spectrum by the modification of TiO2. Two approaches will be followed: (i) nano-mixed phases of wide band gap metal oxides (like WO3 and CuO) and (ii) nano metal cluster (like e.g. Ag-, Cu-, W- clusters) embedded in a wide gap metal oxide as TiO2 is. Both approaches are aimed at influencing the photo-generated carriers and their transport. The nano mixed phases have altogether different band gaps, defect states and defect densities which will influence the electron – hole pair generation with visible wavelengths.",Nanocomposite approaches for the deposition of highly active photocatalytic thin films with plasma technology,FP7,12 July 2015,01 January 2012,0.0 NANOHAPY,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Cancer is one of the most feared diseases. Radiotherapy is commonly used in about 50% of all cancer patients. Although the radiotherapeutic protocols have been improved significantly, only a limited number of patients are entirely cured and severe side effects are often induced. Hadrontherapy and protontherapy are approaches superior to conventional photon radiotherapy because of the maximal energy they deposit at the end of the track (the Bragg peak) and the absence of damage induced behind the tumor. However, the technique is limited by the damage caused along the beam path in healthy tissue located in front of the tumour. Dr. Lacombe's work focuses on improving the hadrontherapy performances using metal nanoparticles (NPs) as radiosensitizers. This is a highly innovative strategy aiming at increasing efficiency and tumour targeting of the treatments. So far, the group focused on the physical properties of the nanoparticles. The objective of my project is to characterize fully the biological effects induced by NPs in DNA and living cells, submitted to medical ion radiations. During the project I will address the cellular toxicity, localization, uptake and quantification of NPs, and I will specifically dissect the cellular response to the combined treatment of NPs and fast ions/protons down to the molecular pathways. To answer these questions, I will make use of the highly advanced experimental instruments and methods available at the host institution and collaborating laboratories. The results obtained during this project will be highly relevant not only for the research community, but also for the industrial sector that synthetizes the NPs and for the medical community who will be closely involved in the project. This multidisciplinary research at the interface of physics, chemistry and biology is unique in Europe and promises novel propositions for future cancer treatments.",Nanomedicine and Hadrontherapy,FP7,30 April 2016,01 May 2014,194046.0 NANOHEAT,Institute of Electronic Technology * Instytut Technologii Elektronowej,photonics,"For advanced nano-devices or Beyond-CMOS structures (sub-40nm transistors, SETs, graphene structures etc.) there is a deep shortage of versatile, multidomain tools capable of analysing phenomena occurring at a nanoscale. The family of AFM-based techniques provides a various nanoscale observation capabilities restricted however to dedicated, particular phenomena. Moreover, available AFM systems do not allow for easy 'domain-mixing' as well as for combination of large distance and nanoscale positioning precision. These techniques are not useful as a in-line monitoring tools. The principle goal of the NANOHEAT project is to develop, deliver and validate a miniaturized and integrated platform which provides a multidimensional nanoprobing platform for advanced thermal analysis at the nanoscale. The multi-functional system of independently controlled AFM-based nanoprobes, equipped with dedicated (FIB functionalized) tips and actuators will allow for multi-domain diagnostics of nanoelectronic, nanophotonic and bio-electronic devices. The proposed system will allow to observe thermal, electrical (e.g. potential) or even chemical (e.g. electrochemical) properties at the nanoscale. It will also have in-line (on wafer) diagnostics capabilities. The consortium is composed of 3 R&D institutes, 4 university teams and 2 SMEs providing a mixture of a complementary expertise related to micro-engineering, design and technology of micro/nano-devices and systems, design and manufacturing of measurement and control electronics, modelling and simulation, material science and physics. Besides, four partners has an expertise and potential required for validation of the developed system for specific applications. The Coordinator, ITE is a leading Polish research centre active in the micro/nanoelectronic, micro/nano-system and photonic domains.",MultidomaiN plAtform for iNtegrated MOre-tHan-MoorE/Beyond CMOS systems charActerisation & diagnosTics,FP7,30 September 2015,01 October 2012,3995000.0 NANOHEATERS,University of Cyprus,information and communications technology,"Nanotechnology offers fertile grounds for research in new ideas to serve the society of knowledge. This project introduces novel reactive nano-heater concepts, based on the exothermic material transformation of thin film pairs, for localized, controlled heating in nanodevices and microsystems. Nano-heaters will offer an innovative and wide-ranging platform for creative basic and applied research in thermal nanotechnology, internationally a virgin field awaiting for European leadership contributions. The nano-heater sources could revolutionise manufacturing, and would be invaluable as on-board thermal actuation and autonomous power sources for the operation of numerous miniature devices, such as nano/microelectro mechanical systems (N/MEMS), nanomotors, biomedical devices etc. Research goals thus arise to study novel nano-heater heterostructures, and to control and analyse their process-material-structure-thermal performance relation and properties interactions during their fabrication, ignition and reaction. The requisite methodology will include laboratory analysis, computational simulation and process control of materials fabrication for universal innovation and industry use. Although based at the Nanotechnology Research Centre of the University of Cyprus, this Marie Curie Excellence project will be broadly shared across Europe, in collaboration with universities and industry and with team members from different EC states. The team initiatives will be pioneered by Prof. Claus Rebholz, possessing outstanding academic and industrial leadership and experience in conducting and administrating collaborative R&D projects between business/industry and the research base at Universities.",Nano-Heater Systems for Thermal NanoManufacturing,FP6,31 December 2009,01 January 2006,1586749.0 NANOHEDONISM,University of Zaragoza * Universidad de Zaragoza,health,"Nerve pain affects millions of people, and can be personally devastating for people who experience it. Current methods for pain management (e.g. local injection of pain killers) are inadequate because of the short duration of action. Even sustained release treatments, such as drug-loaded liposomes, provide only one week of analgesia producing a continuous extended nerve blockade without allowing for changes in daily physical activity or level of pain relief. More importantly, such systems cannot be turned off until they run their course. In this proposal, a locally-injected or implanted near infrared (NIR)-sensitive drug reservoir that can be triggered by a simple handheld laser device applied externally is described. The device enables drug release with consistent response over multiple on/off cycles. Such a device, implanted (or eventually injected) on a nerve or near the neuraxis, could have substantial clinical impact in the treatment of chronic (or prolonged perioperative) pain. This system will consist of an impermeable ethylcellulose membrane embedded with temperature-sensitive polymer nanoparticles and NIR-active gold nanoparticles. The membrane will be engineered such that the nanoparticles form a disordered but interconnected network throughout. The gold nanoparticle concentration will be adjusted so that light-induced heating of the nanoparticles produces sufficient heat to collapse the polymer, thus opening the porous network. Those nanostructured materials which compose the device will be produced in a continuous manner by using microfluidic reactors to avoid the characteristic disadvantages when using conventional discontinuous (batch) reactors. Nanoparticle-synthesis protocols will be supported by computational fluid dynamics. The specific aims will be geared toward engineering a NIR-triggered drug release device and optimizing for a variety of drug types, then demonstrating its biocompatibility and therapeutic effectiveness in vivo.",A Photo-triggered On-demand Drug Delivery System for Chronic Pain,FP7,28 February 2019,01 March 2014,1570091.0 NANOHEX,Thermacore Europe Ltd.,energy,"Henix will translate promising laboratory based nanotechnology results into pilot lines for the production of nanofluid coolants. This project, conceived and led by its European industrial partners, is designed to improve the competitiveness of European industry by developing new and more efficient cooling technologies and processes; specifically a new, state of the art, nanofluid coolant with a significantly enhanced technological capabilities that will transform the design and performance of thermal management systems. Nanofluid coolants represent a new exploitation of nanotechnology that has only become possible as a result of recent advances in nanoparticle production and dispersion technology. The beneficial adoption of nanofluid coolants usually requires re-design of the whole system including heat exchangers, pumps, pipe work and operating points. The gains come from a subtle re-balancing of the pump power, heat losses, plant cost and thermal efficiency. Flow regimes and the geometry of cooling channels play a key role. Understanding how to design systems to realise these benefits is a bottleneck to industrial adoption of nanofluids coolants. The mechanism of how heat transfer is facilitated by nanoparticles in carrier fluids is not clearly understood by the global research community. Analytical Models as yet do not fully explain and predict the thermal performance of nanofluid coolants. The advancement of this knowledge will enable engineers to readily design heat systems using nanofluid coolants. The most promising application opportunities for nanofluid coolants reside in large information data centres containing computer servers and racks, power electronics and power electronics for electric drives. The project will stimulate and accelerate the industrial take-up of nanofluid coolants used to innovate next generation heat exchangers to more effectively cool equipment and machinery, significantly reducing energy consumption and costs by up to 50%.",Enhanced Nano-fluid Heat Exchange,FP7,28 February 2013,01 September 2009,6099582.0 NANOHITEC,OC Oerlikon Balzers AG,energy,"The NanoHiTEC project is focused on planar thermo-electric converters based on super-lattice quantum wells, which have shown on laboratory scale already a figure of merit ZT > 4 for a wide temperature range. The optimization of BiTe based layer systems as well as Si/SiGe and B4C/B9C lattices will be combined with the development of low cost/high throughput industrial deposition processes for multilayers. Direct p-n-junctions at the hot side of the converter promise further increase in performance and long term stability of the devices, but also simplified fabrication. As technologies for improved material performance multilayered nanowires and sintered nanopowders will be investigated. A central point of NanoHiTEC is the optimization of the passive components (thermal and electrical contacts, substrates) and of new geometries for the layout of planar converters to maximize the system efficiency. In this field particular emphasis is given to the heat flow into the hot and out of the cold side of the active elements where actual devices show the most efficiency loss. The developments in the project are backed by partners experienced in the qualification of thermo-electric materials and devices. Besides the parameters defining the thermoelectric performance - measured in a wide range of temperatures, pressures and magnetic fields - the microstructure, dopant distribution and the inner potentials will be investigated by scanning microscopy and TEM (holography). A major part of the project is the simulation of electronic and phononic properties based on the material microstructure. Intense interaction of theoretical work and characterization results of fabricated systems will pave the way for further enhanced material efficiency and better producibility. A main target is the integration in automotive applications where the high efficiency of superlattice systems over a broad temperature range promises good adaptation to the varying conditions in vehicles.",Nano-structured High-efficiency Thermo-Electric Converters,FP7,30 November 2014,01 December 2011,3750000.0 NANOHOLES,Lund University * Lunds Universitet,health,"Cells are highly compartmented by biological membranes. Besides their function as boundaries between organelles, membranes are complex reaction centers with specialized biochemical functions. Although lipid bilayers provide the basic structure of membranes, membrane proteins are responsible for their functional properties. In fact, 25 % of all proteins encoded in the human genome are membrane bound and about 50 % of all current molecular drug targets are located on membranes. Despite their outstanding importance, many membrane proteins have eluded functional and structural characterization due to analytical challenges. We propose to fabricate a localized surface plasmon resonance (LSPR) biosensor based on lipid bilayers suspended over nanoscopic holes in gold films. The ultimate goal will be to incorporate membrane proteins into the suspending bilayers and use this as a platform for studies of protein function and biorecognition. LSPR will enable us to monitor mass changes correlated to the formation of the bilayers, the incorporation of membrane proteins and ligand binding in real-time by monitoring the shift of the absorption spectrum of the nanoholes. Simultaneously, electrical access to both sides of the membrane will provide a read out for membrane protein mediated ion-translocation reactions. Aiming at membrane protein microarray applications, we will immobilize different protein species by controlled fusion of protein-carrying vesicles at recognition elements on the membrane and we will demonstrate the value of the array for screening of ligands.",Membrane proteins in nanometric holes: Real-time monitoring of membrane-mediated reactions by localized surface plasmons,FP6,31 December 2008,01 January 2007,156315.67 NANOHOUSE,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),environment,"NanoHOUSE intends to create a holistic and prospective view on the Environmental Health and Safety (EHS) impacts of nanoproducts used in house building, namely paints and coatings. The latter are using relatively high amounts of Engineered NanoParticles (ENPs) such as nano-Ag and nano-TiO2 which will be investigated. A new Life Cycle Thinking (LCT) approach will be developed gathering two complementary aspects: Investigation of risks and opportunities during the product life cycle as well as Life Cycle Analysis (ISO 14040). LCT will collect information on EHS impacts throughout all life cycle stages of the nanoproducts, identifying the data gaps which will guide the research work. NanoHOUSE will generate reliable scientific information for the missing data and will develop appropriate methods to analyze the potential EHS impacts of nanoproducts. NanoHOUSE first task will be to quantify the actual sources of ENPs during the use and ageing of actual coatings (weathering, renovation, demolition and final disposal). The project will then characterize the environmental compartments significantly impacted by ENPs released from nanoproducts, measure ENPs concentrations and states in those compartments, and investigate their fate in order to increase the knowledge regarding exposure to ENPs with a view to reducing the risks. NanoHOUSE will study the environmental behaviour and the toxicological effects of actually released ENPs (“aged” ENPs) and compare them with pristine ENPs. Finally, NanoHOUSE will improve the solutions for end of life treatments regarding ENPs release in the environment. Main outcomes of the project will be a scientific risk evaluation of nanoproducts used in building, solutions to improve their competitive and sustainable development by decreasing their potential to release ENPs, and contributions to standard tests for their certification. The NanoHOUSE consortium involves 5 research/academic partners and 4 industrial manufacturers of which 1 SME.",Life Cycle of Nanoparticle-based Products used in House Coating,FP7,06 June 2015,01 January 2010,2400100.0 NANOHY,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),energy,"In order to meet the international goals for hydrogen storage materials, the work in NANOHy aims at combining the latest developments in the metal hydride field with novel concepts for tailoring materials properties. Leading expertise in the field of complex hydride synthesis, synthesis and functionalization of nanostructured carbon, nanoparticle coating, structural characterization, and computational methods will be joined to achieve a fundamental understanding combined with considerable practical progress in the development of novel nanostructured materials for hydrogen storage. The target materials are nanocomposites consisting of hydride particle sizes in the lower nanometer range which are protected by a nanocarbon template or by self-assembled polymer layers in order to prevent agglomeration. Thus, there is potential to lower working temperature and pressure, to enhance the reversibility, and to control the interaction between the hydride and the environment, leading to improved safety properties. Materials of this kind can mitigate or solve principal and practical problems which have been identified recently in other projects. The composites will be synthesized out of novel complex hydrides with very high hydrogen content and nanocarbon templates. Alternatively, hydride colloids will be coated in a Layer-by-Layer self-assembling process of dedicated polymers. Computational methods will be used to model the systems and predict optimal materials/size combinations for improved working parameters of the systems. Sophisticated instrumental analysis methods will be applied to elucidate the structure and the properties of the nano-confined hydrides. An upscale of the target nanocomposite will be made in the final stage and 0.5-1 kg of the material will be integrated and tested in a specially designed laboratory tank. Techno-economical evaluation will be performed and potential spin-off applications will be explored by an industry partner in NANOHy.",Novel Nanocomposites for Hydrogen Storage Applications,FP7,31 December 2011,01 January 2008,2399629.0 NANOHYBRID,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Learning from nature, the major objective of the Nanohybrid project is to develop fundamental knowledge in order to be able to elaborate new melt processable nanophase-separated hybrid materials with controlled architecture, derived from low cost petrochemical olefin feedstocks without sacrificing easy polymer melt processing. On the contrary to most current nanocomposites, where mainly physical bonding between nanofiller and matrix are obtained, the NANOHYBRID project will strive for combining chemical and physical bonding which would allow a real breakthrough in material's properties. The project will be focussed on : 1) Creation of new knowledge related to macromolecular architecture designs via transition metal catalysis which will open up access to novel random and block copolymers (BCs) and polymer product compositions. 2) Understanding the phenomena of nanocompomers' and nanocomposites' formation either during in-situ polymerisation or during melt processing 3) Investigation of fundamental characteristics of the organic-inorganic interphase region by multi-scale analysis. 4) Application-oriented property enhancement, thanks to nanostructured hybrid polyolefins. In the medium to long term, tecton and hybrid approaches to advanced nanostructured polymers via catalytic polymerisation combined with block copolymer self-assembly will offer unique benefits and opportunities for new applications and products. Targeted enhanced properties are: scratch resistance, modulus improvement without sacrificing stiffness, heat distortion temperature, flame retardancy, barrier properties (super hydrofobic/hydro philic, UV radiation, conductivity, antimicrobial, etc.). The industrial sectors concerned could be automotive, communication technology, MEMS, packaging, and textile. The consortium of the NANOHYBRID project involves top scientists from 3 national research centres, 5 academics, 3 industrial technology providers and 2 end users.'",Designed Nanostructured Hybrid Polymers: Polymerisation Catalysis and Tecton Assembly,FP6,29 February 2008,01 March 2005,2070000.0 NANOICP,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,energy,"This project aims to develop new generation of composite material based on TiO2 nanotubes and intrinsically conductive polymer (ICP) deposited in nanotube framework. Our objective is to combine of electrical conductivity of ICP and UV sensitivity of TiO2. Particularly, dye sensitization of TiO2 in conjunction with ICP is of our interest. It is expected that high surface area morphology offered by high aspect ratio nanotube system, which provide extremely high TiO2/ICP interface, will play the key role in specific interaction between conductive polymer and wide band-gap semiconductor. Remarkable electric and optical properties of new composite material are expected. A variety of polymer dopants, electrochemical conditions, and electropolymerization methods will be applied in order to find electrochemical route for successful, homogeneous deposition of ICP`s in TiO2 nanotube system. Two conductive polymers will be electrosynthesized in nanotube 'framework'=>'poly-3,4-ethylenedioxytiophene (PEDOT) and poly-3-hexyltiophene (P3HT). The p-n junction, which is expected at the polymer-semiconductor interface, will be electrochemically controlled by switching polymer between oxidizing and reducing state. PEDOT will be tested as a p-type electrolyte in dye sensitized solar cell device Ti/TiO2/ruthenium-based-dye/PEDOT. P3HT absorbs visible light and thus may replace the dye and the electrolyte, giving the function of charge transport and light absorption. The effects of nano-architecture of the Ti/TiO2/P3HT composite material will be studied in order to meet the dimension of phase separation within the exiton diffusion length of the polymer. Above features make the new composite material very attractive for applications including solar cells and electro-chromic devices. Furthermore, improved bio-compability of the material should find practical applications in biomedicine systems. This project will be taken in close collaboration of Hokkaido University and University of Erlangen.","Self-organized TiO2 nanotubes-intrinsically conductive polymer composite material for applications in solar cells, biomedicine systems, and electro-chromic devices",FP7,14 October 2013,15 October 2009,100000.0 NANOICT,Fundacion Phantoms,information and communications technology,"In the semiconductor industry, CMOS technology will certainly continue to have a predominant market position in the future. However, there are still a number of technological challenges, which have to be tackled if CMOS downscaling should be pursued until feature sizes will reach 10 nm around the year 2015-2020.",Nano-scale ICT Devices and Systems Coordination Action,FP7,12 July 2012,01 January 2008,0.0 NANOIDROPS,Rijksuniversiteit Groningen * University of Groningen,health,"Treatment of eye diseases is severely hindered by the tear fluid and eye lid movement removing the drug. As a consequence, very frequent administration of highly concentrated eye drops is necessary, causing substantial side effects. These side effects occur very often and can range from simple irritations to life threatening anaphylactic shocks in extreme cases. The other shortcoming in treating eye-related diseases is poor compliance, due to frequent dosing. We have developed a drug carrier system for eye drops that have high affinity to the cornea. This allows for a drastically lower concentration of the active compound and less frequent administration. A lower regime results in a better compliance, a higher effectiveness of the drug and less side effects. These nanoparticles can be combined with a wide variety of ophthalmic drugs, including the ones that have been abandoned due to severe side effects. Our approach has been proven during preclinical studies in rat models and even human tissue using two nanoparticle-antibiotic combinations that have shown exceptionally long lasting survival times on the eye of up to four hours. In this project we would like to complete our set of preclinical data regarding efficacy, scope and toxicity of the carrier to achieve commercialization of the drug delivery system.",Nucleic acid nanoparticles for topical ophthalmic drug delivery,FP7,31 January 2015,01 February 2014,150000.0 NANOII,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"We propose a multidisciplinary program, focusing on the development of novel approaches for directing the differentiation, proliferation and tissue-tropism of specific hematopoietic lineages, using micro- and nano-fabricated cell chips. We will use advanced nanofabricated surfaces functionalized with specific biomolecules, and microfluidics cell chips to specify and expend regulatory immune cells for treating diverse inflammatory and autoimmune disorders in an organ- and antigen-specific manner. The proposed cell-chip will create ex-vivo microenvironments mimicking in-vivo cell-cell interactions and molecular signals involved in differentiation and proliferation of hematopoietic cells. Cell chip development and optimization will be supported by high throughput microscopy to select for optimal conditions. 'Educated' cells will be employed for in vivo experiments in mice and the methodology will be further adapted for human cell populations, and applied for clinical diagnosis and therapy as well as the developments of clinically-relevant devices. Regulatory T-cells are extremely promising cells for treatment of inflammatory and auto-immune disease, as well as for tolerance induction in organ transplantation. To be effective they must be produced conveniently, at large numbers with an optimally tuned phenotype. The methodology is suggested to overcome current obstacles in obtaining therapeutically significant numbers of T cells. We propose to apply the suggested methodology for treating different inflammatory or autoimmune diseases including type-1 diabetes using targeted immunotherapeutic approaches. Developing new methods for producing large numbers of finely-tuned and tissue-targeted regulatory cells will make this approach clinically viable. This novel methodology can be extended to directing differentiation of other specific T-cell and hematopoietic lineages, with possible applications for targeting other autoimmune diseases and treating tumors or graft rejection.",Nanoscopically-guided induction and expansion of regulatory hematopoietic cells to treat autoimmune and inflammatory processes,FP7,30 November 2013,01 December 2009,5310000.0 NANOIMAGE,Weizmann Institute of Science,energy,"The invention of new microscopy tools keeps transforming many areas of major economic importance. One example is the semiconductor industry, where sophisticated imaging tools are crucial for maintaining profitable high-volume manufacturing. State of the art tools are routinely used to characterize the dimensions and electrical functionality of manufactured devices, however, as device dimensions continue to reduce there is a perpetual need for the invention of new probing tools that could cope with the new challenges. The goal of this proposal is to make a Proof of Concept (POC) for a new type of nano detector and imaging apparatus, which addresses the future performance challenges for microscopy tools in the semiconductor, solar cell and novel materials industries. The nano detector is a spinoff from a unique nano-assembly technology developed in our ERC Starters project, capable of making the most advanced carbon-nanotube-based electronic devices to date. Based on this new nano detector we intend to demonstrate an imaging apparatus that enables ultra-sensitive imaging of electrical potentials on the nanoscale. The technology is foreseen to improve the current state of the art by orders of magnitudes. We will demonstrate detectors that operate at room temperature, work at high frequencies, are fast, accurate and inexpensive to manufacture - all desirable characteristics for rapid market adoption. In addition to the technological POC, the project comprises innovation protection tasks, the delivery of a relevant business model and networking actions for successful commercialization. The novel detectors would make a vast impact on an important productive sector in Europe. They will contribute especially to yield learning - necessary for maintaining the industry profit margins and competitiveness. The detectors also answer to the current nanoscale imaging challenges in most Key Enabling Technology fields in Europe.",Ultra-sensitive Nanoscale Potential Imaging,FP7,30 April 2015,01 May 2014,149966.0 NANOIMMUNE,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"We have recently developed a bionanotechnology approach to vaccination (Reddy et al., Nature Biotechnology, 25, 1159-1164, 2007): degradable polymeric nanoparticles are designed that: (i) are so small that they can enter the lymphatic circulation by biophysical means; (ii) are efficiently taken up by a large fraction of dendritic cells (DCs) that are resident in the lymph node that drains the injection site; (iii) activate the complement cascade and provide a potent, yet safe, activation signal to those DCs; and (iv) thereby induce a potent, Th1 adaptive immune response to antigen bound to the nanoparticles, with the generation of both antibodies and cytotoxic T lymphocytes. In the present project, we focus on next-generation bionanotechnology vaccine platforms for vaccination. We propose three technological advances, and we propose to demonstrate those three advances in definitive models in the mouse. Specifically, we propose to (Specific Aim 1) evaluate the current approach of complement-mediated DC activation in breaking tolerance to a chronic viral infection (hepatitis B virus, HBV, targeting hepatitis B virus surface antigen, HBsAg) and to combine complement as a danger signal with other nanoparticle-borne danger signals to develop an effective bionanotechnological platform for therapeutic antiviral vaccination; (Specific Aim 2) to develop a new, ultrasmall nanoparticle implementation suitable for delivery of DNA to lymph node-resident DCs, also activating them, to enable more efficient DNA vaccination; and (Specific Aim 3) to develop an ultrasmall nanoparticle implementation suitable for delivery of DNA to DCs resident within the sublingual mucosa, also activating them, to enable efficient DNA mucosal vaccination. The Specific Aim addressing the oral mucosa will begin with HBsAg, to allow comparison to other routes of administration, and will then proceed to antigens from influenza A.",Nanoparticle Vaccines: At the interface of bionanotechnology and adaptive immunity,FP7,30 April 2014,01 May 2009,2499424.0 NANOIMPACTNET,University Institute of Health at Work * Institut Universitaire Romand de Sante au Travail,health,"Recent technological advances allow the targeted production of objects and materials in the nanoscale (smaller than 100 nm). Nanomaterials have chemical, physical and bioactive characteristics, which are different from those of larger entities of the same materials. Nanoparticles can pass through body barriers. This is interesting for medical applications, but it raises concerns about their health and environmental impact. The objective of the NanoImpactNet is to create a scientific basis to ensure the safe and responsible development of engineered nanoparticles and nanotechnology-based materials and products, and to support the definition of regulatory measures and implementation of legislation in Europe. It includes a strong two-way communication to ensure efficient dissemination of information to stakeholders and the European Commission, while at the same time obtaining input from the stakeholders about their needs and concerns. The work plan shows six work packages (WPs: Human hazards and exposures, Hazards and fate of nanomaterials in the environment, Impact assessment, Communication, Integration and nomenclature, and Coordination and management). The work plan will be implemented over four years. Discussions about strategies and methodologies will be initiated through well-prepared workshops covering the WP topics. External researchers and stakeholders will be invited to participate. After these workshops, the researchers will collaborate to produce thorough reports and sets of guidelines reflecting the consensus reached. All of the leading European research groups with activities in nanosafety, nanorisk assessment, and nanotoxicology are represented in NanoImpactNet. All exposure routes, major disease classes and impact assessment approaches are represented within the network. It will coordinate activities within Europe. It will help implement the EU Actionplan for Nanotechnology and support a responsible and safe development of nanotechnologies in Europe.",European Network on the Health and Environmental Impact of Nanomaterials,FP7,31 March 2012,01 April 2008,1999960.0 NANOIMPACTS,London School of Economics and Political Science,health,"Many fundamental issues at the cutting edge of nanoscience will be understood and exploited through the study of single nanoparticles (NPs). The phenomenon of particle-electrode impacts (PEI), due to Brownian collisions of NPs with an electrode held at a suitable potential, enables NPs to be individually addressed, chemically manipulated and interrogated via electrical contact during collisions. We shall address experimental and theoretical aspects of PEI embracing the redox chemistry of metal, non-metal and organic nanoparticles; the use of tagged nanoparticles with tags varying from proteins/DNA (sensing applications) to organic moieties (synthesis and nanoarchitectures); the insertion chemistry of H, Li etc into metal and metal oxide NPs (with application to new battery materials); photoelectrochemistry of semiconducting and sensitised NPs; the aggregation of NPs, single molecule detection via electrochemistry, and controlling the impact environment via optimisation of the impact parameters for particular applications. Theoretical models will be developed to describe and predict the stochastic PEI phenomenon, including the testing of existing theories of electron transfer and transport to and from nanoscale electrodes (Frumkin and Levich exclusion effects). We have pioneered early aspects of this fledgling field and are ideally placed to realise the full potential of PEI studies to a wide range of nanoelectrochemical, analytical, synthetic and sensing applications. We therefore request support for a comprehensive programme of work to expand and fully exploit the field, using the PEI phenomenon to advance the interfaces of electrochemistry with analytical chemistry, biochemistry, materials science and physics (offering myriad applications in synthesis, sensing, nanotechnology, batteries and solar cells) leading to a level of expertise and fundamental understanding prior to ambitious, world-leading experiments in nanoelectrochemistry and in analytical science.",Nano-Impacts: the chemistry of single nanoparticles,FP7,31 March 2018,01 April 2013,2478320.0 NANOINSPECTION,Universiteit Utrecht * Utrecht University,manufacturing,"The pressing need for a more sustainable society has sparked intensive research efforts in search for novel materials with controlled structure, porosity and functionalities. Such porous materials may combine high catalytic activity and selectivity with a long-term stability in the conversion of renewable (e.g. biomass) and non-renewable feedstock when producing future transportation fuels and chemicals. Rational design and optimization of the catalytic properties of these materials is one of the keys for the transition from a fossil fuels based society to a sustainable society.",Near-Field Spectroscopic Imaging of the Assembly and Working of Nanosheets of Catalytic Porous Materials,FP7,03 July 2020,04 January 2013,0.0 NANOINSULATE,Kingspan Research and Developments Ltd,construction,"NANOINSULATE will develop durable, robust, cost-effective opaque and transparent vacuum insulation panels (VIPs) incorporating new nanotechnology-based core materials (nanofoams, aerogels, aerogel composites) and high-barrier films that are up to four times more energy efficient than current solutions. These new systems will provide product lifetimes in excess of 50 years suitable for a variety of new-build and retrofit building applications.",Development of Nanotechnology-based High-performance Opaque & Transparent Insulation Systems for Energy-efficient Buildings,FP7,06 June 2016,07 January 2010,0.0 NANOINTERFACE,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,information and communications technology,"Micro- and nano-electronic components are multi-scale in nature, caused by the huge scale differences of the individual materials and components in these products. Consequently, product behaviour is becoming strongly dependent on material behaviour at the atomic scale. To prevent extensive trial-and-error based testing for new technology developments, new powerful quantitative knowledge-based modelling techniques are required. Current continuum-based finite element models rely intrinsically on extensive characterisation efforts to quantify the parameters present in these models (‘top-down’ approach). On the other hand, state-of-the-art models at atomic scale are able to describe the material behaviour at molecular level, but predictions at product scale are not feasible yet. Through direct coupling of molecular and continuum models, a multi-disciplinary approach in which experimentally validated multi-scale modelling methods will be developed in order to generate new materials and interfaces for System-in-Package (SiP) products with tailored properties and improved reliability within an industrial environment. In this approach, a user-friendly software tool will be realised which incorporates chemical, physical and electrical information from the atomic level into macroscopic models (‘bottom-up’ approach). Furthermore, new and efficient micro- and nano-scale measurement techniques are developed for obtaining detailed information about the most important phenomena at micro- and nano-scale and fast characterisation and qualification of SiPs. An additional important distinguishing part of this project is that, due to the composition of the consortium, the whole industrial development chain is covered: from material development, multi-scale models and experimental methods towards a fully functional commercial software package, ready to be used within an industrial environment.",Knowledge-based multi-scale modelling of metal-oxide-polymer interface behaviour for micro- and nanoelectronics,FP7,08 July 2013,09 January 2008,3300000.0 NANOK,Procter & Gamble Technical Centres Ltd.,environment,The aim of this program is to ensure the efficient transfer of knowledge between the Institute for Surface Chemistry (YKI) and Procter and Gamble. The scope of the project is to forge a long term relationship in the key areas of nanotechnology and nanostructured materials. Nanotechnology is a growing area of importance in science and YKI are seen as a world leading institute. PandG wish to set up a transfer of knowledge to help PandG implement nanotechnology in the consumer products area. YKI also wishes to understand the challenges in the fast moving world of consumer products to increase the industrial relevance of their research programs. A key aim of the program is the development of dye loaded nanostructured silica particles that will revolutionise the beauty care area. These particles are the same size as particles routinely used throughout the industry and have no known health risks. To achieve this aim requires the particles to be accurately structured at the nanometre level with a completely uniform structure. This will allow us to replace the current range of pigments used in cosmetics with a single class of dye loaded nanostructured silica. A further aim of this program is to develop a detailed understanding of how we may modify consumer relevant surfaces at the nanoscale. This will allow for more efficient cleaning and maintenance which will reduce the environmental impact of such products. YKI possesses the detailed understanding of nanoscale absorbsion but lack a detaled understanding of the what the consumer really needs. This TOK will allow YKI and PandG to build initially a comprehensive model what is needed and then to design new too the world nanoscale suface modifiers of relevance to the European consumer.,ToK on Nanostructure and Nanotechnology,FP6,28 February 2010,01 March 2006,492080.19 NANOLANTA,Technical University of Munich * Technische Universität München,information and communications technology,"The paradigm of the project is to develop a whole set of novel 2D and 3D nanostructures of next generation organic materials (lanthanide porphyroids) on metallic surfaces. This experience will help the researcher to become a principal investigator in the near future. The organic nanostructures will be created in ultra high vacuum conditions by molecular beam organic deposition on metallic monocrystalline substrates. The samples will be geometrically characterized by low temperature STM; electrically by STS, XPS, UPS and NEXAFS; and magnetically by XMCD and Kerr at ultra low temperature. The complexity of the project means a quite interdisplinary work both scientifically and technically. A close collaboration is expected among experimental physicists, experimental chemists and theoretical physicists (ab initio and DFT). We will use two porphyroids: phthalocyanines and porphyrins, because of their remarkable temperature stability, photoelectric properties and versatility. These are aromatic macrocycle molecules with a empty cavity in their centre. The idea is first to grow one monolayer film of porphyroid and then filled the cavities by a subsequent deposition of a lanthanide material, creating a single decker. This nanostructure will be used as a template where to study the coordination properties of the huge lanthanide atom. One set of experiments will be related to catalytic properties towards the adsorption of oxygen and carbon dioxide. A second step of experiments would imply the deposition of a porphyroid on top of the lanthanide porphyroid film with the objective of creating a double decker nanostructures (porphyroid/lanthanide/porphyroid). The proximity of the two rings make them promising as basic units for: molecular semiconductors; optical gas sensors (including artificial noses), electrochemical sensors and mass sensors; organic field-effect transistors; and single molecular magnets. These applications are priorities of the European Technology Platforms.",Nanoengineering of functional lanthanide tetrapyrrole systems,FP7,09 January 2011,09 February 2009,169851.34 NANOLEDS,University of Nottingham,photonics,"Research in Nanoscience and Nanotechnology will drive the scientific and technological development of future years with revolutionary perspectives in many aspects of our society. Future large-volume applications will require fast and flexible methods to fabricate and miniaturize electronic and photonic components. This proposal will develop a novel approach to the fabrication of nanoscale light emitting diode (LED) and single quantum dot (QD) LED devices that exploits the laser-driven diffusion of hydrogen in III-V and III-N-V semiconductors. This project will impact a wide community. In fact, nano-LEDs have potential for several applications and interdisciplinary research, i.e. intra- and inter-chip communication, ultrahigh-density information storage, bio-imaging, etc.; also, single-QD LEDs will provide opportunities for fundamental studies of low dimensional structures and their exploitation in nanophotonics. Therefore, this programme of research is well suited to tackle important challenges faced by our society and to generate the knowledge needed to ensure the leadership of Europe in a rapidly growing field. This fellowship will offer Dr. G. Pettinari opportunities to acquire complementary competencies and skills and to reach a position of professional maturity and independence. The fellow will work in an internationally leading institution, The University of Nottingham, with a strong tradition in condensed matter and semiconductors research. The host institution will benefit from hosting a promising researcher whose innovative proposal and previous experience in hydrogen studies and III-N-V alloys will complement an existing research activity at Nottingham on the fabrication of nanoscale LEDs. Of particular interest is the proposal of using hydrogen in the miniaturization of photonic components. This approach has the potential to be implemented in different semiconductor systems and devices, thus opening realistic prospects for a wide range of applications.",A Novel Approach to the Fabrication of Nanoscale Light Emitting Diodes,FP7,31 May 2013,01 June 2011,199549.0 NANOLEM,Queen Mary University of London,health,"Drug delivery transport across the cell membrane involves many biological processes. It is complex and dynamic in nature. In this regard, model lipid membranes which mimic many aspects of cell membrane lipids, are a very useful membrane model. It has been shown that physical characteristics of drug delivery nanoparticles such as polarity and surface charge can significantly influence their interactions with lipids. A clear understanding of the interactions of lipids with drug delivery systems and their transport mechanisms is required to enable the design of an efficient and biologically compatible drug delivery vehicle. The aim of this project is to focus on the physico-chemical understanding of the relationships between the structure of the nanoparticles and their penetration and efficiency as a drug delivery vehicle. In this research, we wish to clarify the mechanisms involved in the interactions between nanogels and dermal membranes and find out how these are influenced by physico-chemical conditions and the morphology of the nanogels. The outcome of this research would aid the design of the next generation of dermal delivery systems and also contribute to the risk assessment of skin exposure to nanoparticles. The scientific challenges to be investigated in this project will focus on the understanding of the molecular mechanisms of interaction between organic nanomaterials and biological barriers, in particular skin. The project will benefit from the combination of high level experimental facilities available in the Host Institute and the longstanding expertise of the group in the development of novel functional nanomaterials for drug delivery applications as well as experience in the area of understanding the biological processes and potential drug targets (by means of e.g. neutron scattering and reflectivity) with the knowledge and experience acquired by the applicant on nanoparticle synthesis, their physico-chemical characterization and interactions.",Understanding the physico-chemical basis of transdermal drug delivery using nanomaterials,FP7,30 April 2016,01 May 2014,231283.0 NANOLICOM,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"Solid State Ionics, as an interdisciplinary science, covers chemistry, physics and materials science. The applied perspectives, that include high-energy-density batteries, fuel cells, electrolysis cells, chemical sensors, electrochromic devices and solar cells, and the need for their improvements are an important catalyst for designing new materials. Besides these attractive applications, academic research needs to be reinforced since ion transport in disordered materials is still poorly understood. In particular, the study of nanomaterials opens new questions related to the relationship between structure, processing and physical properties.The aim of this exchange program lies on the investigation of (i) the grain size effect and (ii) the crystallinity on ionic transport of Li-conducting materials based on perovskites, compounds with Nasicon structure and LiPON. Amorphous, nanocrystalline and microcrystalline oxides and oxynitride will be synthesized as powders and films. Processing of these materials and sintering will be performed to obtain thick films and high density pellets. Influence of micro and nanostructure on Li mobility will be investigated. TEM, SEM could offer a wealth of information on nanostructured compounds. Systematic investigations performed on these materials, using different dynamic techniques, able to probe static and dynamic properties at the microscopic level, will be useful, i.e. Nuclear Magnetic Resonance on 6Li and 7Li nuclei (with their different techniques: static NMR, MAS-NMR, 2D NMR, Pulse Field Gradient), quasi-elastic neutron scattering, broadband impedance and dielectric spectroscopy. In particular, the relationship between structure and physical properties will be clarified to lead to a rational design of ionic conductors and to an improvement of the electrochemical devices. A strong network between complementary scientists (Chemists, Physicists, Materials Engineers) from EU and Ukraine would be valuable to perform this programme.",Nanostructured Lithium Conducting Materials,FP7,31 December 2014,01 January 2011,189000.0 NANOLIFE@WORK,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Protein Quality Control is an essential and evolutionary-conserved process that is present in all kingdoms of life. In cells, both newly synthesized and pre-existing proteins are constantly prone to misfolding and aggregation. The accumulation of damaged proteins can perturb cellular homeostasis and provoke aging, pathological states and cell death. Accordingly, cells have developed an enzymatic machinery -molecular chaperones -that rescues misfolded proteins by catalyzing their conversion back to the native state in an ATP-dependent manner. In this project, the candidate will use state-of-the-art expertise in NMR spectroscopy to address the fundamental questions of chaperone-assisted protein (re)folding. The combination of cutting-edge techniques in methyl-specific isotope-labeling and fast, relaxation-optimized NMR methods will allow real-time characterization of the molecular events in chaperone activity on an atomic scale. The candidate will exploit the unique potential of this approach to dissect the chaperone oligomerization pathway, ATP-dependent conformation cycle, and chaperone-assisted protein (re)folding. Understanding the mechanism of chaperone action could help in the design of new therapeutic agents for aggregation-related diseases such as Alzheimer's disease or cystic fibrosis. Furthermore, the development and use of atomic resolution NMR methods for monitoring active ~1 MDa molecular machines will have a huge impact in structural molecular biology. Finally, the candidate will receive first-class training and career development at a major European structural biology centre. The trans-national move to the host institute will help candidate to build international collaborations and acquire new skills and experience. This diversification and enhancement of scientific and professional competences will enable the candidate to reach a position of professional maturity and independence.",Real-Time Studies of Biological NanoMachines in Action by NMR,FP7,30 June 2014,01 July 2012,201932.0 NANOLIGHT,University of Zaragoza * Universidad de Zaragoza,health,"The aim of the present project is to explore different synthesis strategies to obtain silicon nanocrystals and carbon nanodots with luminescent properties as alternative to conventional fluorescent biomarkers or other light-emitting semiconductor nanoparticles containing heavy metals known as quantum dots. Nanostructured silicon can provide appealing properties such as size and wavelength-dependent luminescence emission in the red/near infrared window, resistance to photobleaching, and robust surface chemistry for grafting of bio-molecules without incurring the burden of intrinsic toxicity or elemental scarcity of quantum dots. Carbon-based nanostructures with fluorescent properties remain relatively unexplored but similar behaviour and properties can be envisaged. The production of silicon nanocrystals will be approached by means of two different methods: i) thermal processing of silesquioxanes to produce an encapsulating oxide matrix for the silicon nanocrystals and ii) laser pyrolysis of silicon precursors either in gas phase or in the form of aerosols containing organometallic precursors. Both methods are quite novel and offer great possibilities for scaling up the batch production of silicon nanocrystals offered by current methodologies. Likewise, the synthesis of carbon nanodots will be explored by both thermal decomposition and laser ablation of carbon-containing precursors. To stabilize the nanoparticles and render them biocompatible for in vitro and in vivo diagnostic imaging experiments, different passivating and encapsulating agents like alkyl or alkoxy-groups and micelle-forming polymers and phospholipids will be evaluated. Finally, fluorescent labelling of cells, evaluation of cytotoxicity, drug-loading, circulation and degradation of selected samples will be carried out.",Synthesis and characterization of NANOstructured materials with LumInescent properties for diaGnostic and tHerapeuTic applications,FP7,31 July 2014,01 August 2011,75000.0 NANOLUM,Complutense University of Madrid * Universidad Complutense de Madrid,health,"This project aims to take advantage of polymeric nanoparticles as a tool for improving sensitivity and performance of (chemi)luminiscence based assays. For instance, highly emissive red/near-infrared (NIR) dyes and long-lifetime luminophores like Ru(II) complexes will be combined in nanoparticles for increased emission efficiencies, better discrimination from background interferences and improved photostability. These beads will be employed for labelling antibodies to be used in immunoassays. Several strategies will be explored, taking advantage of FRET processes, (chemi)luminescence of Ru(II) complexes and high emission efficiencies of red/NIR boron-dipyrromethene (BODIPY) dyes. Additionally, the use of molecularly imprinted polymers (MIPs) as synthetic analogues of antibodies will be explored for the selective recognition and fluorescent indication of analytes containing carboxylic groups. The fabrication of the MIP fluorescent probes in a nanoparticle or core-shell nanoparticle form is expected to improve response time of the sensor and binding of the target analyte, and to allow ratiometric measurements or indication via energy transfer processes. The main task will cover the synthesis of luminescent molecular probes, nanoparticles and luminescently doped nanoparticles and MIPs, with a complete physical and photophysical charaterization. These particles will be implemented in a final stage onto microarray based technologies for monitoring the presence of certain toxins and antibiotics in water and aquaculture products.",Luminescently doped nanoparticles. Strategies for improving sensitivity in luminescence assays and implementation in microarray formats.,FP7,31 August 2012,01 September 2009,45000.0 NANOMA,University of Orleans * Université d'Orléans,health,"The NANOMA project aims at proposing novel controlled nanorobotic delivery systems which will be designed to improve the administration of drugs in the treatment and diagnosis of breast cancer. Breast cancer is diagnosed in 1.2 million men and women globally every year and kills 500,000. The NANOMA project proposes a magnetic nanocapsule steering approach that relies on improved gradient coils for Magnetic Resonance Imaging (MRI) systems. MRI systems also provide concentration and tracking information, real-time interventional capabilities and are already widespread in hospitals. It is based on fundamental techniques and methods for the propulsion, navigation and effective targeted delivery of coated ferromagnetic capsules in the cardiovascular system through the induction of force from magnetic gradients generated by a clinical MRI. This proposed NANOMA platform will be a valuable tool to help enhance the efficiency of breast cancer treatments while improving patients recovery time. The project rests on the pillar of six work packages (WPs) , which are further divided into subprojects (SPs). Substantial RandD activities are carried out in WP1-WP4 with the goal to design, model and control the microcapsule. In WP5-WP6 new biocarriers and biosensors made of ferromagnetic particles and special functionalized materials reacting to environmental changes in infected cancer cells are being investigated. As proof-of-concept, an in-vivo breast cancer cell detection platform is realized and evaluated in WP7. WP8 deals with the effective Europe-wide exploitation and dissemination of the project results. Finally, WP9 manages the project. The project consortium gives almost a guarantee for the project's success.",Nano-Actuators and Nano-Sensors for Medical Applications,FP7,30 September 2011,01 June 2008,2459941.0 NANOMAG,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),information and communications technology,"This proposal aims to establish a research network in the Area of magnetic nanostructured materials for novel spintronic, novel permanent magnets and biomedical applications, through collaboration and exchange of staff among six Prominent European Union Universities and Research Institutes, with top-class International laboratories, three from USA and one from Korea.",Magnetic Nanoparticles and Thin Films for Spintronic Applications and High Performance Permanent Magnets,FP7,03 July 2018,04 January 2012,0.0 NANOMAG-SQ,Bar-Ilan University,health,"Magnetic nanoparticles have a number of present and proposed applications in biology and medicine, such as bio-separation, drug delivery, magnetic resonance imaging and hyperthermia cancer treatment, as well as important role in future high density data storage and spintronic devices. Therefore, there is high interest and strong need to characterize them properly. So far the common characterization method has been to measure a large number of them together in order to accumulate sufficient signal. This is problematic because the magnetic properties of nanomagnets are inherently sensitive to small variations in volume, shape and structure, and this strong variability is averaged in the bulk. It is therefore vital to characterize nanomagnets individually. Successful experiments are rare and required extensive efforts to characterize one single particle. I propose to use a scanning SQUID with sufficient sensitivity and spatial resolution to detect an individual nanomagnet and use the scanning capability to sample many individuals to gain statistics about the variability of their physical properties. In addition to establishing a breakthrough characterization tool, I plan to address physical questions of interest such as the nature of the interactions between small numbers of particles, the dynamics of these particles and the distribution of physical properties. To accomplish this we need an extremely high moment sensitivity, sufficient spatial resolution, minimal magnetic influence of the probe on the particle, and access to various temperatures. These requirements point to the SQUID as an ideal candidate for this task. In the framework of this grant I plan to investigate two types of nanomagnets: FePt particles, which are candidates for biomedical applications; and CoFe dots fabricated on multiferroic materials for electric-field control of local ferromagnetism. The latter is of high interest for memory and logic device applications.",Magnetic imaging of individual nanomagnets,FP7,28 February 2017,01 March 2013,100000.0 NANOMAGDYE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The objective of NANOMAGDYE consists in developing tailored biocompatible magneto-optical nanosystems based on magnetic iron oxide nanoparticles. The project will comprise the elaboration of the nanosystems and the characterisation of their structural, optical and magnetic properties. In vitro and in vivo tests will be carried out to test their biocompatibility. The combination of magnetic and optical properties will be achieved through hybrid nanoparticles made of a magnetic iron oxide core on which an organic layer (dye) will be grafted through a dendrimer molecule and a phosphate entity. This grafting strategy will be extended to bubbles on which magnetic nanoparticles will be attached. The grafting sites will be controlled in order to design new geometries and architectures from rings up to submicronic magnetic spheres. Magnetic nanoparticles with monodisperse size between 2 and 100 nm will be elaborated in order to increase the possibility range of achieved properties. The opto-magnetic nanoparticles will be tested in a medical application and a dedicated magneto-optical probe will be fabricated. Current methods for labelling the lymph node system use a dye (vital blue) or radio nuclide injection detected through optical or Gamma probes, respectively, or a combination of both types of markers. Combining optical and magnetic labelling into a single biocompatible nanosystem will provide higher spatial resolution than presently and avoid using ionising radiation to improve patient safety and medical effectiveness. Stabilized submicronic bubbles labelled with the optical-magnetic nanoparticles will play the role of a contrast agent currently used in echography imaging and facilitate the uptake of the iron nanoparticle, and therefore improve node imaging.",MAGNETIC NANOPARTICLES COMBINED WITH SUBMICRONIC BUBBLES AND DYE FOR ONCOLOGING IMAGING,FP7,31 January 2012,01 November 2008,2375108.0 NANOMAGMA,Consejo Superior De Investigaciones Científicas (CSIC),photonics,"The development of a novel concept of nanostructured material is involved in this project: the proper combination of magneto-optical (MO) and plasmonic elements to produce a magneto-plasmonic material tailored on the nanoscale. The novel magneto-plasmonic materials will offer the unique ability to control their properties in more than one way, since the magneto-optical activity will be affected by the alteration of the plasmonic characteristics and the optical response will depend on the magnetic ones. The latter puts an additional advantage over conventional materials, since the optical response can be actively tuned by means of an external agent: a magnetic field. The project has two main goals; the first is to prepare active magneto-plasmonic materials with tailored properties in the nanoscale and understanding the interactions of the magnetic properties with the plasmonic and optical ones, linked to electric charge oscillations. The second goal is to develop prototypes of applications that can benefit of this coupling. Since it is expected that the optical properties of these materials can be driven by using a magnetic field, this will allow designing and developing novel magneto-plasmonic devices. In particular, as a proof of the applicability of this concept, we will design, fabricate and test a prototype of a new kind of surface plasmon resonance (SPR) biosensor with MO elements, i.e. a surface magneto-plasmon resonance (SMPR) biosensor, comparing its performance against standard biosensors.",NANOstructured active MAGneto-plasmonic MAterials,FP7,31 October 2011,01 November 2008,2963156.0 NANOMAGMOLS,University of Granada * Universidad de Granada,manufacturing,"This research project is devoted to the synthesis of new nanometer-sized entities. There is currently great interest in the synthesis of inorganic materials of nanometric dimensions. The small size of these particles endows them with unusual and novel electronic, optical, magnetic and chemical properties due to their extremely small dimensions. Nano-objects are at the heart of the problem of the miniaturisation of information storage. A simple extrapolation of the present trend in miniaturisation of electronic devices is predicted to arrive at the molecular or atomic level in a few decades!!. Actually, to obtain new perfectly defined (size and morphology) nanometer-sized systems to allow passage from the "mieras" to "nano" there are mainly two approaches: 1- the "bottom-up" approach, which employs the self-assembly of basic components to form molecular components of nanometer size. 2- the "top-down" approach, which involve mechanical degradation of an oxide or metal or physical methods. The fundamental problem to resolve, if we want to use these materials inside a device, is to make the necessary connection between the nanometric entity (molecular) and the macroscopic world, i.e. to get the identical particles to self-assemble in a manner in which they can be macroscopically manipulated. The challenge of this project is the synthesis of magnetic nanoparticles (oxides and cyano-metallate-based coordination polymers) encapsulated in macromolecular and diamagnetic systems with complete control of the size and morphology of the nanoparticles. Specifically, one of the goals of the project will be the synthesis of nanoparticles (Prussian Blue derivatives) inside the apoferritin protein following one of the active research topic in the host institution. We will also use macromolecules as dendrimers or giant polyoxometallates as a template for the synthesis of maghemite, magnetite nanoparticles.",NANOSTRUCTURED MAGNETIC MOLECULAR SYSTEMS,FP6,19 May 2006,20 May 2005,40000.0 NANOMAL,St. George's Hospital Medical School,health,"Malaria is a global health priority that has been targeted for elimination in recent years. Attaining the goals that define elimination of malaria in different countries depends critically on provision of effective antimalarials and further that these antimalarials are used appropriately in individual patients. Drug resistance is a major threat to malaria control and has important global public health implications. Over the past decades the genetic bases for resistance to most of the antimalarial classes currently in use has become defined. For some drugs and combinations, these mutations are the most important predictors of treatment failure. This proposal will innovate new technologies to confirm malaria diagnosis and detect drug resistance in malaria parasites by analysis of mutations in nucleic acids, using nanowire technology, and will result in the development of a simple, rapid and affordable point-of-care handheld diagnostic device. The device will be useful at many levels in malarial control by: 1. Optimising individual treatments for patients 2. Assessing the epidemiology of drug resistance in malaria endemic areas 3. Assessing population impacts of antimalarial interventions The development programme capitalises on highly original and proprietary advances made by QuantuMDx in the field of point-of-care diagnostics. This is complemented by academic expertise that has made major contributions to the understanding of antimalarial drug resistance mechanisms in laboratory models, as well as parasites obtained directly from patients. The impact of this proposal can be extended rapidly to other established and emerging infectious diseases.",Development of a handheld antimalarial drug resistance diagnostic device using nanowire technology,FP7,30 June 2015,01 July 2012,3992150.0 NANOMAN,University of Nottingham,manufacturing,"We will develop new technologies for handling and control of single molecules and nanostructures on the sub 10nm scale. These techniques will be based on atomic force microscopy (AFM) so that manipulation protocols may be applied on insulating surfaces, thus overcoming one of the major limitations of current state-of-the-art techniques. The fundamental processes which control AFM manipulation in nanoscale manufacture will be determined through a collaborative theoretical and experimental exploration of the frontiers of knowledge. The new techniques will enable long term innovation in the areas of molecular nanostructures, controlled self assembly and nanomachines and we will demonstrate several novel applications which form key milestones. The consortium is formed from internationally leading groups in the areas of molecular and nanoscale fabrication and the project directly addresses section 3.4.1.4, of the Priority 3 NMP Workprogramme, 'Development of handling and control devices and instruments'. The project objectives will be achieved through effective management and will be disseminated widely, in particular through an SMEs forum. This project will safeguard the leading status of researchers in the European Research Area and underpin the emergence of key nanotechnologies in Europe. The consortium will also be highly proactive in of wider societal objectives including the promotion of gender equality and the public understanding of science.'","Control, manipulation and manufacture on the 1-10nm scale using localised forces and excitations",FP6,28 February 2007,01 March 2004,1505280.0 NANOMANN,University of Bristol,photonics,"The proposal seeks a Marie Curie Chair for Professor Ian Manners, a Briton currentlyworking at the University of Toronto in Canada. This is to assist the University ofBristol, UK, bring him back to a permanent position in Europe. The proposal amplymeets the objectives of the Marie Curie Chairs (EXC) programme in that Manners is aworld class researcher and an award-winning teacher of undergraduates and researchstudents. The proposal also meets a prime objective of the Work Programme in thatManners' research is in the area of Nanoscience and Nanotechnology, key activities thatFP6 seeks to promote. The resumption of his career in Europe would be acclaimed andsend a powerful signal.The proposed research programme is cutting edge. Synthetic polymers play a criticalrole in everyday life and their broad utility will only grow in the future. At presentpolymer science revolves around macromolecular chains constructed mainly fromcarbon atoms. The proposed research targets the use of transition elements to makepolymer chains with the vision that new processable materials will be created with arange of properties that starts to approach that possible with inorganic solid statematerials with two and three dimensional arrangements of atoms. In line with thisphilosophy, the proposed research focuses on an exciting new research direction -Nanoscience with Metal-Based Polymers. With Marie Curie funding it is proposed toexpand research on polymetallocenes and other metal-based polymers (e.g. metal clusterbased materials) in new directions which will involve applications in nanoscience - anarea of major worldwide challenge and interest for the 21st Century. The proposedresearch will involve three main projects:1. Nanoscience with Phase Separated Metal-Containing Block Copolymers in the SolidState.2. Metallopolymer and Magnetic Ceramic Colloidal Crystals for Photonic Applications.3 Swellable Metallopolymer;",Nanoscience with Metal-Based Polymers,FP6,31 December 2007,01 January 2005,706237.0 NANOMASTER,NetComposites Ltd.,information and communications technology,"The aims of the NanoMaster project are to reduce the amount of plastic used to make a component by 50% and hence reduce component weight by 50%, at the same time as imparting electrical and thermal functionality. This will be achieved by developing the next generation of graphene-reinforced nano-intermediate that can be used in existing high-throughput plastic component production processes.",Graphene based thermoplastic masterbatches for conventional and additive manufacturing processes,FP7,11 June 2017,12 January 2011,0.0 NANOMAT,Kaunas University of Technology * Kauno Technologijos Universitetas,health,"The overall aim of the NANOMAT project is to build the research capacity in converging sciences and micro/nanosystems at the Research Centre for Microsystems and Nanotechnology, Kaunas University of Technology (RCMN-KTU), to the highest European level and create a European Centre of Excellence in Nanostructured Materials. RCMN-KTU is a very promising European research organisation as demonstrated by its participation in five FP5 and FP6 networking projects in the fields of nanoscience and microsystems. The Centre of Excellence will be created through a range of capacity building activities derived from RCMN-KTU's SWOT analysis. The activities will increase RCMN-KTU's competitiveness and visibility in the most advanced topics of converging sciences and micro/nanosystems: 1. Nanostructures by ionic self-assembly of porphyrins; 2. Near field optical microscope for cells research; 3. Electro-mechanics of cells and biostructures; 4. Growth and formation of carbon nanotubes structures by chemical vapour deposition; 5. Development of gas sensors based on functionalized porphyrin nanotubes; and 6. Development of micromachined silicon cantilevers for scanning shear force microscopy applications. Central to the activities are twinning partnerships with 3 specialist research groups: Centre for Nanoscience and Quantum Information, University of Bristol; Micro and Nanosciences Laboratory, Helsinki University of Technology; and the National Centre for Microelectronics, Barcelona. RCMN-KTU will increase its human potential by hiring 3 young experienced Lithuanian researchers and organising training stages. RCMN-KTU will increase its technology potential by upgrading its existing scanning probe equipment by Nano-Raman,TERS, confocal microscopy and purchasing a controlled frequency synthesizer and ultra-high resolution frequency discriminator. Finally, the NANOMAT project addresses research priorities identified by the EU Technology Platforms MINAM and Nanomedicine as well as FP7 NMP and ICT Work Programmes.",Centre of Excellence for Nanostructured Materials,FP7,31 March 2012,01 April 2009,795550.0 NANOMAT,INNOVA Europe SARL,transport,"This project aims to encourage and facilitate the participation of Small and Medium Sized (SMEs) companies
from the candidate countries in FP6, in particular in the nanotecnologies and nanomaterial fields, through the
provision of in-depth technological intelligence and innovation assistance services.
In order to accomplish this mission, the project partners, which come from nine EU and candidate countries (CZ,
DE, ES, FR, HU, LU, PL, RO, SK), will support SMEs with the following actions:
• Raise awareness on EU funding opportunities and promote R&D cooperation.
• Gather information on relevant Integrated Projects (IP) and Networks of Excellence (NoE) already being
developed, as well as on FP5 project results. Provide assistance and intermediation services to the
coordinators of these Integrated projects (IP) and Networks of excellence (NoE) in order to promote the
incorporation of additional SMEs as technology providers or end users. In total, 60 companies are
expected to be incorporated in ongoing projects of IP and NoE, and follow up activities of the selected
successful 5th FP RTD projects, facilitating the creation of new groupings with the existent partners.
• Perform 100 company technology audits in order to identify needs, current capabilities, best practices
and future developments needs.
• Support SMEs to put eligible and successful proposals together. Support the submission of 22 EC RTD
proposals, amongst cooperative research projects (CRAFT), collective research projects and specific
targeted research projects (STREP).
• Provide 200 SMEs with technological intelligence services in the nanotechnology and nanomaterial
fields.
• Dissemination to 500 SMEs of good practices and of innovative research results to sectors of potential
application. The sectors where the NANOMAT project will concentrate are the automotive, electronics
and health sectors.
• Tailor-made training to 300 SMEs in economic and te","A targeted action to encourage the participation of SMEs in the 6FP, in the nanotechnologies and nanomaterials fields (NANOMAT)",FP6,17 June 2006,18 December 2003,911321.0 NANOMAT-EPC,Intelligentsia consultants Sàrl,health,"NANOMAT-EPC aims to support the deployment of societally beneficial nano- and materials technologies in European Partnership countries (EPC), in order to increase exploitation of their scientific results and contribute to the United Nations Millennium Development Goals. Consequently, NANOMAT-EPC aims to develop knowledge and technology transfer in nano- and materials technologies for healthcare, clean energy and environment applications. The project will be implemented by a well-balanced consortium of nine partners -four EPC partners and five EU partners. In order to stimulate the knowledge and technology transfer, NANOMAT-EPC's mission is the following: i. Map and promote organisations involved with nano- and materials technologies in EPC; ii. Organise brokerage events in the EPC to facilitate knowledge and technology transfer in nano- and materials technologies; iii. Organise workshops in the EPC to identify nano- and materials knowledge and technology transfer opportunities; iv. Implement pilot nano- and materials technologies deployment projects. The pilot projects will be bilateral between the EPC and European partners and based on education, training and exchange of scientists as follows: a. Deployment of high conductivity zirconia anodes in solid oxide fuel cells (IPMS and UB) b. Deployment of hybrid CNT/graphene electrodes for supercapacitors (BSUIR and Cleancarb) c. Deployment of nanosensory devices for environmental monitoring using picosecond laser technology (GTU and PSUD) d. Deployment of magnetic nanoparticles for medical applications (IPR-NAS and LZH) v. Produce report with recommendations on how to exploit to nano- and materials knowledge and technology transfer opportunities in EPC.",Deployment of Societally Beneficial Nano- and Material Technologies in European Partnership Countries,FP7,31 October 2015,01 November 2013,563500.0 NANOMATCELL,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),energy,"Dye-sensitized solar cell (DSSC) is the leading technology of third-generation solution-processed solar cells with reported efficiencies in excess of 10%. However despite the huge efforts in the last two decades saturation effects are observed in their performance. Efforts so far have been concentrated towards engineering and fine-tuning of the dyes, the electrolytes and the interface of the dye to the electron acceptor, employing titania as the electron acceptor. DSSCs rely, then, on dyes for efficient light harvesting which in turn entails high fabrication costs associated to the Ru-based dyes as well as the use of 10 um thick devices. In addition, optimized titania requires high-temperature processing raising concerns for its potential for low-cost, flexible-platform fabrication. In this project we propose a disruptive approach; to replace titania with a novel electron accepting nanoporous semiconductor with a bandgap suitable for optimized solar harnessing and a very high absorption coefficient to allow total light absorption within 2 um across its absorption spectrum. In addition the deposition of the nanostructured platform will employ processing below 200oC, compatible with plastic, flexible substrates and cost-effective roll-to-roll manufacturing. We will focus on non-toxic high-abundance nanomaterials in order to enable successful deployment of DSSCs with targeted efficiencies in excess of 15% and 10% for SS-DSSCs, thanks to efficient solar harnessing offered by the novel nanocrystal electron acceptor. To tackle this multidisciplinary challenge we have assembled a group of experts in the respective fields: development of nanocrystal solar cells, DSSC technology and physics, atomic layer and surface characterisation and a technology leader (industrial partner) in the manufacturing and development of third generation, thin film, photovoltaic cells and modules (DSSCs).",NOVEL ENVIRONMENTALLY FRIENDLY SOLUTION PROCESSED NANOMATERIALS FOR PANCHROMATIC SOLAR CELLS,FP7,31 December 2015,01 January 2013,2722101.0 NANOMATCH,National Research Council * Consiglio Nazionale delle Ricerche (CNR),construction,,Nano-systems for the conservation of immoveable and moveable,FP7,10 July 2016,11 January 2011,0.0 NANOMATCH,Eberhard Karls University of Tübingen * Eberhard Karls Universität Tübingen,energy,"NANOMATCH is an interdisciplinary and intersectorial research and training network in the emerging field of nanoscience and -technology. The project aims at the development of tailored photo- and electro-responsive organic/inorganic hybrid systems such as photovoltaic cells, LEDs, and electro-optic modulators, by combining the advantages of organic and inorganic materials. Widespread application of polymeric materials is mainly restricted by their limited chemical stability and lack of control of (inter-)molecular order. In our approach, these limitations are overcome by hierarchical organization of matter at different scales. A. Molecular control is attained by the 'oligomer approach', to tailor the molecules to specific applications such as 'stopcock' and anchor molecules, color-tuning, high PL and NLO efficiencies, as well as energy (ET), electron (eT) and proton transfer properties. B. Control at the nanoscale is achieved by the supramolecular concept of host-guest compounds, with active molecules encapsulated in (in-)organic hosts, to obtain chemical stability, intrinsic polarization, enhanced lasing-, PL-, NLO-, ET- and eTefficiencies, as well as energy funneling. C. Control at the microscale is fulfilled by matching the nanostructured microscopic objects to the 'outside world', through selfassembly, deposition on patterned surfaces, (non-)covalently binding via the 'stopcock principle', inkjet printing, and homogeneous dispersion in polymers. The control of order in this approach opens new possibilities in device technologies, but also deepens the understanding of elementary processes such as energy- and electron transfer in 3-dimensional molecular arrangements and at the organic/inorganic interface by full-control of the structural, electronic and optical parameters. Thorough understanding is accomplished by state-of-the-art structural, photophysical and electrical characterization as well as by theoretical modeling at each step of the project.",Supramolecular nanostructured organic/inorganic hybrid systems,FP6,31 August 2010,01 September 2006,3682047.0 NANOMECH,Technical University Dresden * Technische Universität Dresden,health,"Molecular machines---assemblies of macromolecules, often fueled by nucleotide hydrolysis---are fascinating devices and crucial for driving self-organization in cells. While protein components of many biological machines have been identified, and in many cases their structures have been solved, the mechanical principles that govern the operation of biological machines are poorly understood. For example, how much force can they generate; and what limits their speed and efficiency? These questions have been difficult to answer because the tools needed to study nanometer-sized machines that generate minute forces on the order of piconewtons have not been available until recently. Friction arises between proteins when they interact by making and breaking weak intermolecular bonds. When a bond breaks, the energy stored in its deformation is dissipated. Protein friction is a useful concept because it provides mechanical insight and allows for quantitative theoretical understanding of the dynamics and energy balance of mechanical cellular processes. In cells, many motor proteins often cooperate to drive motility. I will ask how friction and force-generation arise and scale with the number of motors to elucidate how collective behavior and self-organization emerge. The goals of this interdisciplinary project address the role that protein friction plays in limiting the dynamics and efficiency of microtubule-based motor proteins using a novel, combined optical tweezers and single-molecule fluorescence apparatus. In the long term, I hope that our avant-garde nanotechnological tools will be applicable to other molecular machines and that the studies on microtubule-based motors will shed light on the way that cells use energy to create pattern and order.",Protein Friction of Molecular Machines: Nanomechanics with Optical Tweezers,FP7,30 November 2015,01 December 2010,1500000.0 NANOMECHAMYLOID,University of Cambridge,health,"The conversion of normally soluble and functional proteins into insoluble protein aggregates known as amyloids are linked to more than 50 human disorders, including several common forms of age-related dementia such as Alzheimer's and Parkinson's diseases. Amyloids exist as long, rope-like structures known as fibrils which can self-associate into intractable plaques-a hallmark of many amyloid-related diseases. Here we propose to investigate the potential role the material properties of amyloid, in particular their rigidity and propensity to break, play in both the pathology and transmission of amyloid-related disorders. We propose to study the material properties of amyloid using a new and ground-breaking form of microcopy known as 4D ultrafast electron microscopy (UEM). This unique microscope combines the spatial resolution of electron microscopy (nanometer) with the temporal resolution of laser spectroscopy (femtoseconds) and can directly apply minute (piconewton) forces to materials, making atomic-scale 'movies' of the resulting displacements. This sets it apart as the technique of choice for characterizing the stiffness and fracture mechanics of proteinaceous nanofibrils such as amyloid. Using this revolutionary technique, we hope to determine the stiffness of amyloids, use amyloid as a single molecule biosensor, perform optical trapping experiments on individual Alzheimer's disease-related fibrils within the column of an electron microscope and study the destruction of cataract-related amyloid plaques. These results will provide us with some fascinating insights into the molecular forces governing the behavior of amyloids and how this may relate to their pathology in living organisms.","Investigation of the relationship between the material properties of insoluble, protein aggregates known as amyloids and common forms of age-related dementia such as Alzheimer's and Parkinson's.",FP7,29 February 2016,01 March 2013,282561.0 NANOMED,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,tbc,DEVELOPMENT AND DEMONSTRATION OF A CARBON NANOTUBE ACTUATOR FOR USE IN MEDICAL TECHNOLOGY,FP6,14 September 2008,15 September 2004,1496752.0 NANOMED ROUND TABLE,Technische Universiteit Delft * Delft University of Technology,health,"The fundamental objective of this Round Table exercise is to respond substantially to the need for genuine engagement and involvement of all the key stakeholders (public and private) in the nanomedical field in preparing the groundwork for optimised and collective decision-making at the European level. Although very promising, nanomedicine may add new dimensions to many ethical, social and economic issues. It is of primary importance to understand its possible impacts and provide for stakeholders a well-organised forum. The Round Table will bring together representatives from the nanomedical sciences and technologies involved, industry, patient groups, regulatory bodies, health insurance and policy making, and experts on the ethical, regulatory, social, economic and public engagement and communication and issues. The goal will be to: - collect the most relevant information to be discussed of: - actual achievements and, separately, promises of nanomedical innovation - recommendations issued by the European Commission, Member States and exercises carried out by various national and international bodies - present these in a 'user-friendly' format appropriate for each of the main stakeholder groups with questions to be discussed - carry out a consensual debate concluding with agreed recommendations between various positions The Round Table will have important impacts by: - establishing a clear set of recommendations to support decision making at the European level - identifying priority areas for research and development and for societal actions - significantly enhancing the flow of knowledge reciprocally between each of the key stakeholder groups along the chain from research to patient - helping to reduce fragmentation in nanomedical research across Europe - contributing to mobilising additional public and private investment in nanomedical R&D in Europe - and overall thereby stimulating innovation in nanobiotechnologies for medical use","Nanomedicine ethical, regulatory, social and economic environment",FP7,30 June 2010,01 January 2009,687135.0 NANOMED2020,VDI/VDE Innovation + Technik GmbH,health,"Nanotechnology applied to medical applications, Nanomedicine, is one of the most important emerging areas of health research and is understood to be the most promising out of the six KETs, for innovative devices and materials for personalised, targeted and regenerative medicine. However, due to the complexity of technologies and medical application areas Nanomedicine requires many different so far independent stakeholders from academia, industry and regulatory bodies. Due to the diversity of stakeholders the partners of this project will initiate a strong coordination and support action to build a pertinent European Nanomedicine community involving all key players necessary to define the resources, gaps and needs for development and implementation of nanomedical research into marketable innovations to be used by doctors for the benefit of patients. The implementation concepts will also target the initiation of Public Private Partnerships for the creation of novel infrastructures and innovative funding programmes. Nanomedicine research is growing fast in many countries. Therefore, the project consortium will initiate international collaborations in the Nanomedicine area, especially the coordination of international regulation of Nanomedicine products. The partners involved in the project represent major European networks combining academia, industry, clinicians and public authorities. Based on this strong partnership and after integration of further national and European initiatives the output of this support action will be a strong, established partnership of relevant stakeholders in identified key areas of Nanomedicine with new concepts for translation of nanomedical innovations into clinical practice and efficient and transparent communication channels. This will make Nanomedicine an important contributor to the future European healthcare system with a beneficial impact on improved treatment for patients and on social challenges such as ageing population.",Enabling the European Nanomedicine Area until 2020,FP7,28 February 2014,01 September 2012,499647.0 NANOMEDICINE/IMAGING,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The proposed research will explore new strategies in nanomedicine and develop novel materials for drug delivery, molecular imaging, proteomics and metabolomics. The four main objectives can be summarized as nanoparticle assembly, application of nanoparticles to molecular imaging, novel ligand design for drug delivery and viral detection and inhibition. Assembly of nanoparticles into unique signalling platforms will be achieved via novel ligand design for gold and silver nanoparticles and will enhance the utility of such particles towards molecular imaging. Success will make vibrational microscopy using functionalized nanoparticles a viable alternative to fluorescent probes for medical imaging. Applications in molecular imaging will focus on visualizing proteins at the surface of neurons with glycosylated nanoparticles to understand how these signalling proteins change in number and localization in response to stimuli and how these protein traits vary between healthy and diseased neurons. These data are critical in understanding the causes and progression of neurodegenerative diseases. This research will result in novel opportunities for therapeutic intervention, which itself may be possible using the functionalized nanoparticles as drug delivery agents. Glycosylation of the surface of the nanoparticles is critical for improving the bioavailability of nanoparticles for this objective. In the third objective of this project, photo-cleavable groups will be introduced into the nanoparticle ligand framework and used to release drugs at targets upon two-photon excitation of the nanoparticles. Thereby a single photon is emitted that can cleave the photo-labile group binding the drug to the particle. Finally, glycosylated nanoparticles will be used to image hepatitis C viral particles in vivo and to inhibit their entry into liver cells.",Nanoparticle development for molecular imaging and drug delivery,FP7,31 August 2013,01 September 2011,225945.0 NANOMEGA,Norwegian Institute for Air Research * Norsk Institutt for Luftforskning,health,"As nanotechnology and materials science have progressed, large quantities of engineered nanoparticles (NPs) have been produced. NPs promise to revolutionize our lifestyles by improving many industrial and consumer products. However, there is considerable concern about their unknown impact on human health: with their unique physicochemical properties (size less than 100 nm), NPs differ from the corresponding bulk material. Here we address the urgent need to determine the potential effects of NPs on human health and environmental safety. Our objectives are: a) To develop and optimize a novel approach to in vitro NP testing using an epithelial cell culture model that mimics in vivo interactions of particles with cells; b) To study mechanisms of NP toxicity using cardiovascular/cardiopulmonary cell models to identify specific markers of oxidative stress and their role in activating signal pathways associated with the inflammatory response, DNA damage and repair; c) To investigate protection by omega-3 fatty acids against inflammatory effects of NPs, and possible modulation of DNA repair, in an in vitro model. This research will provide information on mechanisms of action of metal oxide NPs, and specifically on their effect on risk of cardiovascular/cardiopulmonary diseases. The results will contribute to protecting European public health, and will be crucially important for formulating policy on safety of nanotechnology. The ambitious research tasks provide an excellent opportunity for the career development of Dr. Rinna in this new field. By developing innovative techniques mimicking in vivo conditions, carrying out experiments on potential NP toxicity, and investigating how cells and DNA can be protected against injury, she will acquire an impressive range of expertise. By supervising master and co-supervising PhD students, she will improve her management and teaching skills and thus establish a base for a longer term position as a research team leader in Norway",Novel approach to toxicity testing of nanoparticles mimicing lung exposure. Possible protective effect of omega-3 acids,FP7,12 December 2013,01 April 2010,204568.0 NANOMEM,University of Gothenburg * Göteborgs Universitet,health,"Modern structural biology builds upon synergies between lab-bench scale science on the one hand and large scale research infrastructure on the other. NanoMem recognises the transformative opportunities that are created by current X-ray source and detector developments to impact strongly on membrane protein structure, a challenging sub-field of structural biology. We will exploit synchrotron based micro-focus X-ray beams to address challenging diffraction studies from small membrane protein crystals; and embrace the revolutionary possibilities created by X-ray Free Electron Lasers to deliver an entirely new regime of high-resolution serial femtosecond crystallography of membrane proteins. These developments will place heavy demands on motivated and highly-trained talent. The time is ripe for bringing young scientists into the loop. Nanomem will train the nucleus of a new community spread across Europe that widens the access and use of non-conventional methods to capture membrane protein structures at high resolution. Our interdisciplinary and intersectorial research training work programme incorporates membrane protein production, purification and crystallisation, micro and nano-crystal manipulation, micro-focus diffraction at synchrotron sources, nano-focus diffraction at X-ray free electron lasers, serial femtosecond crystallography, software development, drug design, and commercialisation of the most helpful innovations. On-site scientific training of nine ESRs and one ER with seamless industrial participation will be complemented with training in areas such as intellectual property, communication skills and scientific mentoring. The current major European effort in the construction of new brilliant X-ray sources has to be matched by an investment in nurturing the birth of a scientific community for its exploitation, pushing the limits of our understanding of membrane protein structural biology.",Membrane Protein Nanocrystallography,FP7,31 December 2016,01 January 2013,2814628.0 NANOMEND,University of Huddersfield,energy,"NanoMend will pioneer efforts to develop better, more integrated process inspection, cleaning, repair and control systems for nano-scale thin films on large area foils, and will do so in two exemplar vertical supply chains for functionalized polymer-coated paper products and for low cost flexible photovoltaics (PV). The aim is to demonstrate beyond state-of-the-art in-line detection, cleaning and repair of micro and nano-scale defects. The NanoMend strategy to develop novel optical inspection methods has three strands: 1.Enhance the effective lateral resolution and the vertical resolution of high speed optical inspection systems currently used to scan large area foils. 2. Develop high precision optical interferometric sensors with significantly higher spatial range and scan speed than existing laboratory interferometers. 3.Build and test prototype optical interferometers that can detect defects which have a spatial size below the diffraction limit (down to approximately 10nm) by utilizing a priori knowledge of the geometry of the defects and inverse modeling approaches. The NanoMend strategy for cleaning is to decrease defect density and enhance yield by using directional cleaning methods optimized for i) continuous operation to remove sub-micron defects from large area foils prior to barrier deposition, and ii) local removal of particles generated during fabrication of PV modules. Local repair techniques will be investigated in particular for interconnection defects detected near the end of PV module manufacture where the value of the work to be recovered is very high. NanoMend solutions proposed for inspection, cleaning and repair will be integrated into a) production of large-area photovoltaic panels for use in building-integrated systems with demonstrable long life (15-20 years) and b) production of polymer-coated papers used in fibre-based packaging solutions.","Nanoscale Defect Detection, Cleaning and Repair for Large Area Substrates",FP7,31 December 2015,01 January 2012,7250000.0 NANOMESH,University of Zurich * Universität Zürich,information and communications technology,"The NanoMesh project is based on the recent discovery by one of the proposing groups of a spectacular nanostructure of hexagonal boron nitride that self-assembles on a rhodium metal surface [M. Corso et al., Science 303, 217 (2004)]. It is a supported, mesh-like structure consisting of two atomic layers with a periodicity of 3.2 nm and holes of about 2 nm. The relevance of the project to the thematic area 3.4.1.1 is twofold. With roughly 400 boron and nitrogen atoms in the mesh unit cell, the self-assembly process is truly remarkable, and it is accessible to live observation by surface science techniques, including scanning tunneling microscopy under process conditions. By elucidating the self-assembly mechanism in this highly non-trivial case, the project is very likely to provide new and general insight in this efficient and cheap type of nanostructure formation. The second key point of relevance lies in the nature and the stability of the boron nitride nanomesh. It is inert and stable up to 1000 K, and it thus lends itself perfectly as a template or scaffold material for forming secondary nanostructures. Metal deposition on the nanomesh is expected to produce highly monodisperse metallic nanoclusters that represent prime candidates for catalysts with high activity and selectivity, or for nanostructured magnets with superior magnetic or spintronic properties. The edges around the pores of the mesh permit the stable covalent attachment of organic or even biological molecules of desired functionality, thus leading to well structured functional surfaces. The attachment of large molecules should lead to higher hierarchies of self-assembling supramolecular structures that should be very interesting for biotechnology applications. In full expectation of these applications, the project also addresses the production issues related to precursor molecules and substrates.","Nanomesh - Boron Nitride Nanomesh as a Scaffold for Nanocatalysts, Nanomagnets and Functional Surfaces",FP6,30 June 2008,01 April 2005,2599667.0 NANOMESO,Paul Scherrer Institute,information and communications technology,"The aim of NANOMESO is to develop knowledge in nano-micromechanics and to develop a validated computational tool to understand and predict unique plasticity phenomena experimentally observed. In nanotechnology object scales are determined by optimised functionality resulting in ever shrinking sample size dimensions to the sub-micron regime and decreasing structural length scales such as grain size to the nanometer regime. The experimentally observed size dependent plasticity is not explained by existing theories. Since the mechanism occurring span multiple time and length scales, a multiscale computational approach is required where knowledge is transferred from ab-initio across atomistics to the mesoscale (sub-micron-scale). The atomistic pathways and energetics of the deformation mechanism in confined systems with interface dominated structures will be determined and implemented in a dislocation dynamics code allowing simulation of mechanical behaviour in a one-to-one scale with experiment. The NANOMESO consortium involves leading-edge US and EU theoreticians and modellers that have already a great expertise in the field. The full integration of two leading experimental groups in nano-micromechanics into the project (with national financial support) and the EU-project leader having an international reputation for both computational and experimental approaches in nano-micromechanics, guarantees maximum synergies between experiment and modelling. The performance-oriented objectives are advancing the frontiers of knowledge in multifunctional materials science. NANOMESO will help to overcome the initial barrier that usually prohibits or decelerates the use of novel materials/components due to a lack in theory/understanding. NANOMESO will support long-term innovation relevant to industrial applications of multifunctional metallic components such as in MEMS-devices by constructing a predictive tool, lowering investment costs for European industry.",Size Effects in Mechanical Properties,FP6,28 February 2009,01 March 2006,1000000.0 NANOMICEX,"Instituto Tecnológico del Embalaje, Transporte y Logística (ITENE)",environment,"The main aim of NANOMICEX project is to reduce the potential risk upon workers’ exposure to the engineered nanoparticles employed in the operative conditions of the inks and pigments industry, by addressing at the health and environmental consequences associated with the inclusion of nanoadditives within all stages of nanotechnology based products (production, use and disposal). To achieve it, new surface modifiers will be designed and developed to obtain less hazardous and more stable nanoparticles. The proposed work will focus on a selected set of nanoparticles relevant to the ink and pigment sector. Full characterisation will be carried out, followed by an exposure measurement in order to characterise and quantify any potential particle release in the production and processing activities. A comprehensive hazard assessment will allow the evaluation of effects on human and environmental models with comparisons between simple and modified nanoparticles carried out. Results from the assessment studies will be used to compile a risk assessment of the use of nanoparticles in the ink and pigment industry, and comparisons will be made with surface-modified nanoparticles. An evaluation of the effectiveness of risk management measures will be undertaken in order to select and design practical and cost effective strategies, which will be easy to implement in the real operative conditions. As part of this assessment, we will conduct a life cycle assessment, by evaluating their impacts during the whole process of manufacture, use and disposal of these products.",Mitigation of risk and control of exposure in nanotechnology based inks and pigments - NANOMICEX -,FP7,03 July 2017,04 January 2012,0.0 NANOMICROTRIBOLOGY,AC2T Research GmbH,information and communications technology,"The components of microelectro mechanical systems have very high surface to volume ratio. The forces applied to such systems are quite low making surface forces to play a dominant role. However, as the sizes of such systems are quite low, the contact pressure is estimated to be few hundred MPa. Such forces cause undesirable effects such as stiction and high friction leading to reduction of operational reliability. The main objective of the proposal is to enhance the performances of MEMS by applying self-lubricating film on the surfaces, which are sliding against each other’s. In order to achieve the above mentioned objective, transition metal dichalcogenides (TMD), and DLC will be deposited on Si, steel and glass substrate. Pulsed laser deposition (PLD) technique and magnetron sputtering (MS) technique will be employed for that purpose. Metal containing TMD and DLC will also be deposited on similar substrates. The mechanical properties of these films will be determined using, nanoindenter. These films will be characterized with the help of TEM, XPS, and FTIR etc. The micro tribological properties will be evaluated using a micritribometer. The nanotribological properties will be examines with the help of an, AFM equipped with a nanoindenter and a nanoscratch tester. These evaluations will be carried out in controlled environment and in corrosive environment. The friction force surfaces, topography induced friction surface and adhesion induced friction surfaces will be obtained under various conditions. Attempt will be made to identify and characterize presence of transfer layer. The mechanism of friction disipation will also be examined.",Comparative Evaluation of Tribological Performances of Transition Metal Dichalcogenides and DLC Thin Films in Micro and Nano-Scale,FP6,30 April 2009,01 May 2007,213885.36 NANOMICROWAVE,The Bio Nano Centre Limited,health,"Current applications of microwave technologies in communications, remote sensing and in industry are based on the properties of the interaction of microwaves with matter at supra-wave length scales (above centimetres). The developments performed in Nanotechnology in recent years makes now conceivable to explore the interaction of microwaves with matter at much smaller scales, from micrometres to nanometres. At these sub-wave length scales it is expected that fascinating new physical phenomena may appear, which will give rise to new applications of microwave technologies with high added value, in particular, in field such as nano-electronics, nano-spintronics, nanobiology and nano-medicine. Being an emerging technology there is a need for training early stage researchers in this field of research so that enough critical mass can be achieved. The main objective of this network is to train a whole generation of researchers in the field of nanoscale microwave technologies and related emerging applications in the fields of semiconductor industry and life sciences. The researchers of the network will acquire a state of the art multidisciplinary scientific training in this field of research, covering from basic science to industrial applications, thus enabling them to generate new knowledge with high impact. In addition, they will receive a practical training on transferable skills in order to increase their employability perspectives and to qualify them to access to responsibility job positions in the private and public sector. The final aim of the network is to help Europe to position and consolidate in a leading position in the field of nanoscale microwave technologies and related applications.",Microwave Nanotechnology for Semiconductor and Life Sciences,FP7,31 December 2016,01 January 2013,4063807.0 NANOMINING,Metal Forming Institute * Instytut Obróbki Plastycznej,health,"Silver nanoparticles and silver based nanostructured composites are being frequently used in a variety of biomedical and industrial applications, such as an antimicrobial agents, lead-free solders, electric contact materials, gas-sensitive sensor, etc. The most complicated Silver using problems are related to: i) recovery of silver from ore waste materials; ii) the controlled synthesis of metal nanoparticles of well-defined size, shape and composition; iii) nanoparticles incorporation to desired implant surfaces; iv) synthesis of Silver based nanostructured composites for industrial purposes. The main goal of the Project is to develop: 1. Clean and efficient procedure of silver recovery from waste: Combined Mechanical Activation -Thermal Oxidation Processing jarosite type residues to alleviate and accelerate the following precious metal leaching; 2. Combined nanotechnology of biological synthesis (use of plants for the nanoparticles synthesis) of Ag nanoparticles and its deposition on implant surfaces by electrophoretic and plasma spraying deposition; 3. Nanostructuring technology of Silver based nanocomposites manufacturing for electrical contact applications. Pilot production and trials of developed Ag nanoparticle modified implants and Ag based nanostructured composites: 1. TiO2 and Hydroxyapatite Ca10(PO4)6(OH)2) coated implants which are widely used in orthopaedic surgery because of their good biocompatibility related to the osteoconductive properties of calcium phosphate coating; 2. Ag-SnO contacts for electrical systems; these composites combine high resistance to welding and to electric arch erosion of the refractory phases with the high electric and thermal conductivities.",Development of new nanocomposites using materials from mining industry,FP7,30 September 2013,01 October 2010,1800000.0 NANOMMUNE,Karolinska Institute * Karolinska Institutet,health,"Engineered nanomaterials (ENs) present tremendous opportunities for industrial growth and development, and hold great promise for the enrichment of the lives of citizens, in medicine, electronics, and numerous other areas. However, there are considerable gaps in our knowledge concerning the potential hazardous effects of ENs on human health and the environment. Our EU-US partnership is committed to filling these knowledge gaps through a comprehensive assessment of ENs, with particular focus on effects on the immune system. The immune system is designed to respond to pathogens and foreign particles, and a core concept underpinning the current project is that the recognition versus non-recognition of ENs by immune-competent cells will determine the distribution as well as the toxicological potential of these materials. Our multidisciplinary consortium will focus on the procurement, synthesis and detailed physico-chemical characterization of representative categories of ENs, and the monitoring of potential hazardous effects using an array of in vitro and in vivo systems, as well as transcriptomic and oxidative lipidomic testing to determine specific nanotoxic profiles (signatures) of these materials. The final and integrative component of our research project is risk assessment of potential adverse effects of ENs on human health, and the dissemination of our findings. Through our comprehensive approach, which combines analytical procedures from many different disciplines and leading experts from several national institutes devoted to occupational and environmental safety, we aim to establish a panel of read-out systems for the prediction of the toxic potential of existing and emerging ENs, thus enabling a continuous and sustainable growth of the nanotechnologies. Overall, the results generated through this international program will contribute to the understanding and mitigation of possible adverse effects of nanomaterials.",Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system,FP7,31 August 2011,01 September 2008,3358500.0 NANOMODEL,BASF SE,health,"The practice of adding micron sized inorganic filler particles to reinforce polymeric materials can be traced back to the early years of the composite industry. With synthetic methods that can produce nanometer sized fillers, resulting in an enormous increase of surface area, polymers reinforced with nanoscale particles should show vastly improved properties. Yet, experimental evidence suggests that a simple extrapolation of the design paradigms of conventional composites cannot be used to predict the be-havior of nanocomposites. The origin of these differences between conventional and nanocomposites is still unknown. This, unfortunately, precludes yet any rational design.Though some property improvements have been achieved in nanocomposites, nanoparticle dispersion is difficult to control, with both thermodynamic and kinetic processes playing significant roles. It has been demonstrated that dispersed spherical nanoparticles can yield a range of multi-functional behavior, including a viscosity decrease, reduction of thermal deg-radation, increased mechanical damping, enriched electrical and/or magnetic performance and control of thermomechanical properties. Especially the decrease in viscosity is advantageous for injection-molding op-erations. Facile tuning of nanocomposite Tg could thus allow us to control the usable temperature range of these materials. Again, the physics under-pinning this behavior remains unresolved, primarily due to the poor understanding of the effects that particle/matrix interactions have on the composite behavior. This project aims at overcoming these deficiencies by a twofold strategy. This project will bring together a critical mass of scientists, from atomistic to finite-element modeling. The goal is to develop, implement and validate multi-scale methods to compute the mechanical, thermochemical and flow behav-iour of nano-filled polymeric materials -based on the chemistry of selected model systems.",Multi-Scale Modeling of Nano-Structured Polymeric Materials: From Chemistry to Materials Performance,FP7,31 October 2011,01 November 2008,3481149.0 NANOMOF,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,environment,"The discovery of porous hybrid materials constructed from inorganic nodes and organic multifunctional linkers has established a new area of inorganic-organic hybrids (Metal-Organic Frameworks, MOFs) with extraordinary performance as compared to traditional porous solids such as zeolites and activated carbon. “NanoMOF” will focus beyond discovery and integrate MOFs into products with industrial impact within a strong cooperation of established MOF research institutions and industrial end users. The extraordinary properties of MOFs are expected to lead to a significant ecologic and economic impact in three areas: 1) Clean air, pollution, and toxicity risks of gaseous chemicals are environmental concerns with specific materials needs for selective adsorption in porous materials and advanced filter systems. Industrial feed gases and exhaust gases require a high purity to ensure durable processes and avoid pollution. The integration of MOFs into textile products will be used to develop air permeable personal protective clothing. For industrial and house-hold fuel cell reformer units novel MOF-based sulphur removal systems will be developed. 2) Safe delivery of highly toxic electronic grade gases (etching gases, dopants) is crucial for tool operation in semiconductor and solar industry. 3) Catalysis is an ecologically relevant and economically attractive technology. The replacement of liquid acids by solid state catalysts avoids the production of toxic liquid waste. MOF catalysts for (trans)esterification processes are designed for the conversion of fatty acids and triglycerides into valuable products for the oleochemical industry. The integration of MOFs into industrial relevant processes and products is supported by advanced modelling, simulation and process monitoring techniques. The project aims for a higher integration of MOFs into products with a high added value in order to propel Europe into an internationally leading position in the industrial use of MOFs.",Nanoporous Metal-Organic Frameworks for production,FP7,05 July 2015,06 January 2009,5100000.0 NANOMOT,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The mission of NANOMOT is to engineer sub-cellular building blocks that can be flexibly assembled into robust biomimetic nanoengines and nano-labs with controllable functionality not found in nature. We will study the components of biological nanomotors and explore their potential to assemble them in new ways and new functions. The single molecule lab-on-a-chip is one of the long-term application visions that drive NANOMOT; chemical nanoreactors and nano-actuators are mid-term visions. NANOMOT will master control over three nanomotors developed by nature, (a) the F0F1 ATPase, (b) the ???29 viral head tail connector, and (c) the flagellar motor. NANOMOT will provide flexible, robust, and adaptable interface modules for the set-up of complex systems for new functionality. The three nanomachines have in common that either their structure and mechanism and/or their function have recently been characterized to unprecedented accuracy, providing the timely basis to now successfully move on into engineering new minimal systems that yield a particular behaviour. The success of NANOMOT will be evaluated by demonstrating that the new building blocks can be assembled into a highly specific molecular drug delivery device. By pushing the emerging field of bio-nanotechnology, our transdisciplinary synthetic biology approach links nanotechnology with structural biology and systems biology. Moreover, NANOMOT addresses the challenge to prepare the grounds for a new engineering field. To meet this challenge, we have assembled a unique high rank international consortium which in very close collaboration joins forces across the relevant disciplines, engineering, molecular biology, physics, computer science, chemistry, as well as across the required fields, protein and metabolic engineering, x-ray crystallography, cryo electron microscopy, single molecule spectroscopy, nano-optics, single molecule atomic force microscopy, and molecular dynamics simulations.",Synthetic Biomimetic Nanoengines: A Modular Platform for Engineering of Nanomechanical Actuator Building Blocks,FP6,30 November 2009,01 February 2006,2250000.0 NANOMOTION,University of Aveiro * Universidade de Aveiro,energy,"The focus of modern solid-state technology is currently shifting from the single property (electric, magnetic, and elastic) to a coupling of different fields where a coupled materials response can be either used for their characterization or as a basis of novel applications. In the last few years, it became clear that the coupled electromechanical response of the materials (i.e., mechanical deformation under applied electric bias) can be not only used as an universal tool for studying diverse materials classes at the nanoscale but is becoming indispensable for the development of next generation of multifunctional materials (piezoelectrics, ferroelectrics, multiferroics, ionic conductors, and polar biomaterials) and composites on their base. Novel nanoelectromechanical tools (Piezoresponse Force Microscopy - PFM, Electrochemical Strain Microscopy - ESM, and as well their combination with traditional Scanning Probe Microscopies - SPM) have been introduced for studying emergent materials and applications. This has recently led to the substantial progress in the development of novel multiferroics, photovoltaic, biopiezoelectrics and battery materials. The emergent field of nanoelectromechanics requires coordinated action at the European level as further progress in this field largely relies on the education and dissemination of best practices in application of PFM/ESM to a large number of functional materials NANOMOTION is intended to train the next generation of engineers and technologists in the fundamental aspects of the nanoelectromechanics, to apply advanced PFM/ESM tools to study a wide range of functional materials in collaboration with interested industrial partners and to create a European-based pool of researchers in this area.",NANOELECTROMECHANICAL MOTION IN FUNCTIONAL MATERIALS,FP7,31 October 2015,01 November 2011,3350360.0 NANOMULTIMOLSWITCH,Joseph Fourier University * Université Joseph Fourier,information and communications technology,"Recent developments in molecular electronics and nanotechnology, in general, offer the promise of devices, of great relevance to information technologies, with unprecedented capabilities including memory devices with extraordinary storage capacity as well as circuit elements of vanishing size and superlative speed. Some of the molecular entities that have shown particular promise, to date, include donor/acceptor (D/A) assemblies, transition metal complexes and others. Of particular importance has been our ability to encode information and/or achieve electronic functionality by the storage or movement of charges. This proposal addresses two separate projects which are part of general investigations of nanoscale materials chemistry. The first project will focus on the development of molecular architectures at the nano-scale level toward molecular electronics applications. Molecular switching systems will be investigated and their capability to act as molecular wire allowing the electrons flow through the conjugated system will be tested. Upon establishment of their photoelectrochromic properties, binuclear metallic complexes will be synthesized to study of intramolecular electron transfer through mixed-valence species. By precisely modulating the spacing in between the redox units, we will investigate, with unprecedented control, self-exchange rates in redox reactions, the distance dependence of electron transfer, and photoinduced electron transfer. Subsequently, we will proceed to immobilize the binuclear compounds connected through the corresponding switch on gold or platinum surfaces by taking the advantage of the ability of thiol or nitrile functional groups to bind properly on such surfaces. We thus propose a seed project where we will explore the two areas described above and assess their potential utility as a means of reversibly and reproducibly making contact to nanostructures, for information encoding and as conduction modulators.",REDOX AND CONDUCTING ROUTING IN MOLECULAR ELECTRONICS. NANOSCALE ARCHITECTURES AND NOVEL PHENOMENA,FP7,02 April 2013,03 January 2009,168279.59 NANOMYC,Agricultural University of Athens,health,"WHO reports that tuberculosis results to millions of deaths or disabilities each year, especially in poorer areas of the planet. The problem is exacerbated by the AIDS epidemic that increases disease incidence in developed countries too. However in addition to tuberculosis, exposure to mycobacteria has also been linked to the pathogenesis of sarcoidosis and Crohn's disease that affect millions of people in Europe only. Diagnostic investigation of mycobacterial infections is hampered by the difficulty to detect in a specific manner low populations of mycobacteria or the immunology markers associated with the infections they cause. The NANOMYC project aims to develop a highly sensitive and specific, quantifiable detection system for molecular and immunology diagnostic markers associated with infection caused by M. tuberculosis complex (human and animal tuberculosis, implicated in sarcoidosis) and M. paratuberculosis (animal paratuberculosis, implicated in Crohn's disease). To this goal the consortium will combine nanotechnology and molecular biology incorporating the recent advances on the sequencing of mycobacterial genomes to routine diagnostics. Experts on mycobacteria genetics and nano-technology will produce a number of biomolecules that will be conjugated to a set of functionalized quantum dots with different oproelectrochemical characteristics. The NANOMYC assay will be developed in order to be applied for: a) in-field diagnostics using portable devices for evaluation of liquid samples, and b) manual and automated evaluation of solid samples using fluorescence resonance energy transfer. The final product will be a world innovation and it will target a market of several billion euro/year. Marketing of the NANOMYC assay will be used to sustain the project's administrative and financial platform and continue research activities in order to further the proposed technology for in-vivo diagnostic and therapeutic applications.",Multiparametric detection of bio-molecule conjugated nanoparticles for the diagnostic investigation of mycobacterial infections of humans and animals,FP6,28 February 2010,01 January 2007,2194020.0 NANONEUROHOP,University College London,health,"While neurodegenerative disorders and brain cancers increase in the population, current therapies have shown their limits. But thanks to recent advancements in nanosciences and nanotechnologies, new therapeutic opportunities are offered based on the development of nanoscale drug delivery systems. Among those, carbon nanotubes (CNT) have shown promising applications for therapy of a broad range of diseases because of their highly tunable abilities to transport different molecules and to penetrate cells. In this multidisciplinary project, we propose to use chemically functionalised CNT (f-CNT) as drug delivery systems for brain disease. However, since the knowledge concerning the interaction of CNT and the brain parenchyma is poor, the main goals of the project will be to define: (i) the potential hazard of using f-CNT in the brain and (ii) the pharmaceutical opportunities that these nanocarrier systems could offer. Our overall objective will be to identify critical parameters for the design/engineering of safe and effective carbon nanotubes based drug nanovectors for brain disease, with a special focus on the CNT surface functionalization. We will use both in vitro and in vivo studies to adresses these different questions.",Assessment of the hazard and opportunities of using carbon nanotubes as a new nanocarrier for drug delivery in neural tissue,FP7,30 June 2013,01 July 2011,199549.0 NANONEUROPROTECTION,Imperial College London,health,"Development of new strategies to treat neurodegenerative diseases is one of the key priorities of the European Union. Their socioeconomic burden is rapidly growing due to the increasing lifespan and the decreasing percentage of working population, currently costing the EU €130 billion a year in care. Despite efforts put in development of treatments for neurodegeneration, the bench-to-bedside translation of neuroprotective strategies remains very low. Major factors contributing to this problem are incomplete understanding of the mechanisms behind neuronal injuries, lack of compounds affecting multiple protective pathways/cell types, and side effects caused by broad-spectrum neuroprotectants. A separate crucial problem is the limited blood–brain barrier (BBB) passage of most compounds. Therefore, identification of effective therapeutic targets in the brain and delivery of novel low-cost neuroprotectants with minimal side effects and high BBB passage is of paramount importance. The emergence of nanoneuroscience is revolutionizing treatment of CNS disorders. This approach uses nanometer-scale materials, which can interact with biological systems at a molecular level, bypass cellular barriers and induce desired physiological responses in cells with minimal side effects. The project proposed here combines advanced methods of nanoscience and neurobiology to (1) characterize novel therapeutic targets and neuroprotective pathways in the brain and (2) design novel efficient nanoprotectants against neurodegenerative conditions, such as stroke, epilepsy, Parkinson's and Alzheimer's diseases. The project will offer exemplary training for the Fellow in nanoneuroscience, as well as in project management skills, at Imperial College, ranked the 5th highest university internationally. These competencies will complement the already impressive range of the Fellow's research and managing capabilities and will help her to develop as a leader in this frontier area of science.",Nanomaterials for treatment of neurodegenerative disorders,FP7,31 March 2016,01 April 2014,299558.0 NANONLO,National Hellenic Research Foundation * Ethniko Idryma Erevnon,photonics,"The objectives of this project concern the development of new competences at the host for (a) the development and processing by thermal poling of novel materials, and (b) the characterization of second-order nonlinear optical (NLO) properties induced by synthesis or post-synthesis treatments. Inorganic glasses, glass-ceramics and nanostructured organic-inorganic hybrids will be considered due to their potential in the field of photonics. The proposed research is driven by the current needs of optical communication technologies for versatile and inexpensive materials with NLO properties, which could replace eventually the difficult to synthesize and expensive ferroelectric crystalline materials used nowadays. To achieve the objectives, the work plan involves research and development activities for the fabrication at the host of experimental set-ups for thermal poling and for measurement of second-order nonlinear optical properties, and for the synthesis and investigation of novel materials with potential NLO properties. In the context of the project, the host institute will recruit three experienced researchers in (i) thermal poling and NLO properties measurements, (ii) nanostructured glass-ceramics, and (iii) organic-inorganic hybrid materials. In addition, training of host staff researchers is planned at two highly experienced partner laboratories in Bordeaux, France, to ensure durable transfer of knowledge in the sought new competences.",Nanostructured Materials with Nonlinear Optical Properties,FP6,09 July 2010,10 July 2006,702997.84 NANOOXIDES,Bielefeld University * Universität Bielefeld,health,"It is generally accepted that nano materials 'will revolutionize our industries and our lives' (Nobel laureate R. Smalley). We wish to extend our work on unique metal-oxide nano materials, which offer signposting routes due to their structures/forms -like our worldwide highlighted and used spherical capsules with 20 gated pores -to study novel phenomena with impact for basic research as well as applications. These nano materials should now be adjusted regarding size, chemical composition, their linking to extended structures, and a variety of new tailored internal functionalities in order to get appropriate properties of interest for different purposes of nano science and technology. Among the examples are: the protection/stabilization of intermediates and transport of the encapsulated materials after pore closing, systematic studies regarding the generation of hydrophobic cavities with and without water (of importance for protein research and even related to drug design), the removal of a variety of hydrophobic (potentially toxic) compounds from water based on molecular recognition (a paradigmatic shift) and finally, stepwise capsule closing and opening related to allosteric effects. The intended work on the capsules should open doors for the understanding of phenomena in small spaces. Also materials based on the related wheel-shaped metal-oxides with unprecedented properties (i.e. soft matter behaviour) will be investigated.",Nanosized porous molecular metal oxides with functionalizable cavities and soft matter behaviour allow studies of new phenomena,FP7,31 January 2016,01 February 2013,1128400.0 NANOP,Imperial College London,health,"A novel analytical platform is proposed to detect and identify DNA at low concentration in a high throughput manner at the single molecule level. The potential impact of this research is significant and will result in single molecule detection becoming a mainstream tool within the medical diagnostics and analytical communities. 'Rare event' detection plays an important role in the early detection of illnesses and disease (e.g. cancers and bacterial infections). Using analytical technologies that exist today it is almost impossible to detect a single DNA strand within a standard blood sample (of a few mLs) within a reasonable time frame. The technology that will be developed within the current project will allow for such detection to be performed both rapidly and efficiently. If successful, the core technology described will become a mainstream analytical tool that will be of significant benefit within biomedical laboratories, hospitals, and clinics around the world. Specifically, chemical and semiconductor processing methods will be developed to define a novel approach to high throughput DNA quantification at the single molecule level. This innovative technology will function by introducing biological samples in micro- and nanofluidic chips and using electric fields to direct DNA strands through nanometre-sized pores on a membrane. Detection and sizing of the individual DNA strands (labelled with fluorophores) is then accomplished using confocal fluorescence spectroscopy. This new approach to high-throughput, single molecule DNA analysis harnesses the strengths of both analytical spectroscopy and silicon fabrication technology to allow the creation of hybrid devices in which molecular quantification can be realized. I expect this work to have major impact and open up new possibilities for nano-analytical tools in the chemical and biological sciences.",Nanoporous Membranes for High Throughput Rare Event Bio-analysis,FP7,31 December 2016,01 January 2012,1497620.0 NANOPACK,Thales SA,information and communications technology,One of the major limitations to continued performance increases in the semiconductor and power electronics industries is integration density and thermal management. Continued transistor downscaling is quickly reaching its limits forcing a new focus on heterogeneous integration and 3D packaging technologies to continue performance improvements by reducing interconnect length between memory and multi-core logic. These efforts must combine high density electrical interconnects with low resistance thermal interfaces to remove heat from the intricate layered assemblies. Power electronics applications in hybrid vehicles and power supplies are also being pushed to new integration densities that are largely limited by the ability to transfer heat across interfaces to liquid coolers and heat sinks. Improved thermal management and integration densities for these applications will also be important to improve energy and manufacturing efficiency and component reliability.,Nano Packaging Technology for Interconnect and Heat Dissipation,FP7,09 June 2013,11 January 2007,0.0 NANOPAD,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"Diagnostic devices made of patterned papers devices, termed microfluidic paper-based analytical devices PADs, are a new platform designed for ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and robust, Equipment free and Deliverable to end-users) point-of-care POC diagnostic assays. PADs overcome many disadvantages of strip test devices and offer completely new opportunities to POC. The design paradigm of PAD is based on creating a complete Lab on a chip, including 2D/3D micro fluidic systems, filtering, biosensing and readout, all combined on a stamp sized piece of paper. The use of conventional paper as a substrate for developing PAD depends on numerous advantages: - The porous structure of paper allows manipulation of fluids through the bulk of the materials, allowing for active fluidics, and filtering. - Paper is thin, lightweight, many dimensions and form factors, easy to stack, store, and transport. - Cellulose is compatible with biological samples, and can be chemically functionalized to bound to proteins, DNA, or small molecules. - Paper is flammable, so PADs can be disposed of by incineration easily and safely after use - Compatibility with printing technologies enables micro fabrication PADs cheap and efficient. In this project conducting polymer based organic electrochemical transistors will be printed inside PADs and used as a tool for high sensitive diagnostics in PAD. Nanofibrialted cellulose and nanopaper will be explored for creating new and highly sensitive PAD devices, specially for colorimetric analysis on enzyme markers, and enzyme linked immunosorbent assays (ELISA) Finally chemically functionalized nanofibrilated cellulose will be explored for covalent attachment of proteins inside nanopaper for high-sensitive and precise paper diagnostics.",Nano cellulose based paper diagnostic devices,FP7,31 August 2016,01 September 2013,375374.0 NANOPAGE,Claude Bernard University Lyon 1 * Université Claude Bernard Lyon 1,environment,"The NANOPAGE project will focus on the development of a flexible large area display made by assembly of microCRTs into a polymer canvas. Those microCRTs are millimetre size cold-emission cathode ray tubes, used as elementary color dots, 3 microCRTs, red, green and blue, making a complete pixel. Those microCRTs use nanometer scale Carbon Nanotubes (CNT) as cold electron sources. The first type of microCRTs, with a 3 mm diameter, will allow to build a 4x3 m panel with SVGA (800 x600) resolution. The main tasks are : - to industrialize a low-cost lab proven technique for controlled growth of vertically aligned CNTs. - to develop highly automated assembly techniques to manufacture the miniature vacuum tubes in large quantities and to mount them on the polymer substrate. - to develop an innovative addressing scheme, where a miniature microchip is mounted on each microCRT. This scheme allows to : - bend, cut or repair the display as there is no peripheral drivers - control locally the microCRTs light emission - correct non uniformities due to manufacturing or aging. Cost targets are integral part of the project objectives, to insure a very competitive pricing of the end product. We will carefully consider the product recycling and avoid any use of lead, mercury or other toxic materials. It is expected that the low cost and flexibility of such a display product will significantly increase the large area display market as it should open up new applications which are today limited by the performance of existing large area display solutions. As those microCRTs are small tubes, manufacturing does not require a large size reactor, oven or other expensive equipment, so the capital investment for a complete line is moderate and modular, adjustable to the production volume. This limited and progressive funding requirement, together with automation, gives a significant chance to implement the manufacturing line in Europe, as anticipated.",Flexible Large Area Display using Nanotechnology Light Emitting Devices,FP6,30 June 2007,30 June 2004,2240000.0 NANOPARTCAT,Universiteit Utrecht * Utrecht University,health,"Supported metal nanoparticles are used as catalysts to accelerate and steer chemical conversions to produce, e.g., transportation fuels, chemicals and medicines. Albeit of eminent importance, supported metal catalysts are almost exclusively synthesized in liquid-phase processes that are often considered 'an art rather than a science'. Although recent results from our laboratory and others on the fundamentals of catalysts synthesis have led to many new insights, the lack of methodology to investigate directly the formation of supported nanoparticles in the liquid phase hampers progress. The key objective of this proposal is to image and thereby obtain a detailed understanding of both the genesis (synthesis) and the dynamics (catalysis) of supported metal nanoparticles in the liquid phase with nanometer resolution and in real time. To this end we will combine two recent developments: (1) a liquid-phase in situ cell for use in a transmission electron microscope (TEM) with (2) the element specificity of a Chemi-STEM that provides element specific images with nanometer resolution.. In this way we will image in the liquid phase the nucleation and growth of nanoparticles on a support. As support we plan to use materials with ordered porosity that allow imaging of genesis of nanoparticles in liquid confined in nanopores. The key objective of this proposal will be addressed in four projects (1) acquisition and implementation of a liquid-phase cell within a Chemi-STEM which is then used to study (2) ion adsorption of noble metal complexes onto silica and zeolites followed by liquid-phase reduction to form metallic nanoparticles, (3) crystallization of metal nitrates in nanopores of silica and carbon, (4) dynamics of palladium nanoparticles in liquid-phase catalysis. The new insights will move catalysts synthesis 'from art to science' and provide control over the properties of supported nanoparticles to arrive at novel catalysts for sustainable processes.",Supported Nanoparticles for Catalysis: Genesis and Dynamics in the Liquid Phase,FP7,31 March 2019,01 April 2014,2500000.0 NANOPCM,Acciona Infraestructuras SA,construction,"The overall objective of NANOPCM is the development, implementation, production, and demonstration of low cost and improved Phase Change Materials for new high performance insulation components in existing buildings. For this purpose, different technical innovations will be carried out during this project: 1. New low cost stable thermal storage component based on the anchorage at nanoscale of organic PCMs between the polymeric chains of selected polymers. The PCMs will be based on by-products of different industries. 2. New thermal insulation inorganic nanofoam with thermal storage capacity by the impregnation with inorganic or organic phase change materials. The nanoporous material will help to improve the thermal behaviour of the PCM and the innovative use of hydrated salts (inorganic PCM) in construction materials. 3. Improve the thermal behaviour of the materials developed with the introduction of high thermal conductive nanomaterials, CNT or CNF inside their structures. 4. Improved organic phase change microcapsules with the incorporation of high thermal conductive nanomaterials, CNT or CNF in the shell which will provide better thermal transfer to the organic paraffin inside. The objectives of this project will be achieved through 8 WP´s. WP1 is dedicated to project management, WP2-WP3 are related to the experimental development of the new materials and its characterization, WP5 to the study of the Life Cycle, the recycling possibilities and the minimization of the process cost. Finally, in WP4, WP6, WP7 and WP8 will be dealing with the validation, demonstration and dissemination of the results.",New Advanced iNsulatiOn Phase Change Materials,FP7,05 July 2015,06 January 2010,2399652.0 NANOPDT,Joseph Fourier University * Université Joseph Fourier,health,"Photodynamic Therapy (PDT) is a clinically approved cancer treatment relying on the use of a photosensitizer, i.e., a fluorescent molecule producing cytotoxic species upon irradiation with light. PDT also provides the ability to image and locally treat diseased tissues without ionizing radiations, thus sparing healthy tissue. Yet, only five photosensitizers are now approved for clinical applications and all suffer from serious drawbacks, including low selectivity and skin sensitization. Photosensitizer-loaded nanoparticles could potentially solve these problems. They can accumulate at the site of tumors by either passive or active targeting. Their physicochemical properties can also be tuned to accelerate clearance, and reduce non-specific binding. In this study, we propose to investigate a novel class of polymer-based organic nanoparticles whose most relevant physicochemical properties can easily be tuned by controlling synthesis parameters. Benefiting from expertise of researchers at the Beth Israel Deaconess Medical Center (Boston, MA, United States), the research fellow will design a wide range of polymer fluorescent nanoparticles. These particles will be tested to find a formulation with optimal blood half-life, low non-specific binding and good targeting capabilities. The research fellow will then synthesize and test the most efficient particles at the Institut Albert Bonniot (Grenoble, France) on head and neck tumor rodent models using 2D and 3D fluorescence imaging. The PDT efficacy will be monitored by following tumor growth and survival rate of the animals. This fellowship application has the potential to solve a longstanding problem in PDT while providing outstanding international training and promoting the career of a talented European researcher.",Efficient Tumor Targeting and Therapy Using Near-Infrared Nanoparticles,FP7,31 October 2015,01 November 2012,268555.0 NANOPEC,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"To address the challenges of photon capture and energy conversion, we will investigate solar-driven hydrogen production via photoelectrochemical water splitting. Although the concept is extremely attractive as a method of sustainable fuel production, no single material with acceptable performance, stability, and cost has been found, despite decades of investigation. To address this significant challenge, we will use new concepts and methods, afforded by nanotechnology, to design innovative composite nanostructures in which each component performs specialized functions. These novel nanocomposites will decrease the number of criteria that any single component must meet, thus overcoming the basic materials limitations that have hindered development. Computational studies will be used to assist in the selection of optimal material pairings and a wealth of advanced analytical techniques will be employed to improve the understanding of structure-composition-property relationships. As a final objective, we will use NanoPEC's innovations to develop a 1 square-centimeter test device that converts solar energy to hydrogen energy with a sustained 10% efficiency and a maximum performance decay of 10% over the first 5,000 hours of operation and a 100 square-centimeter test device with a sustained 7% efficiency and similar stability, representing a performance standard that goes well beyond the state-of-the-art. NanoPEC's innovative research will redefine the field of photoelectrochemistry and place Europe at the forefront of nanoscience and nanotechnology research by contributing to leadership in this strategically important area.",Nanostructured Photoelectrodes for Energy Conversion,FP7,31 December 2011,01 January 2009,2699909.0 NANOPERMAG,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),energy,"The development of a new generation of permanent magnets is more urgent than ever in view of the demand for more efficient engines in wind energy, all electric cars and space applications. The purpose of this proposal is to exploit the opportunities available to fabricate powders of magnetically hard rare earth intermetallic nanoparticles/nanograins to develop new classes of anisotropic nanocomposite magnets with previously unattainable high energy products, (BH)max . We will use both 'top-down' and 'bottom-up' approaches to develop these materials. This program will be directed towards the synthesis and investigation of magnetically hard powders consisting of anisotropic Sm-Co, Sm-Fe-N and Nd-Fe-B nanoparticles with sizes below 300 nm, and soft powders based on Fe(Co) nanoparticles with sizes in the range of 10-20 nm and with properties close to those of the bulk. We shall use a variety of different fabrication techniques including chemical and mechano-chemical synthesis, surfactant assisted milling, and cluster gun deposition. Research will be focused on the 2:14:1/Fe(Co), 1:5/Fe(Co), 2:17/Fe(Co) and Sm2Fe17Nx/Fe(Co) nanocomposite systems. Micromagnetic calculations will be used to model different architectures for the optimum performance using parameters including particle size and shape, the geometrical arrangement of the hard and soft nanoparticles, and hard/soft structures with core/shell morphology. These modelled nanostructures will be fabricated for comparison with theoretical predictions and further optimisation. The emphasis will shift towards the blending, alignment and consolidation of the hard/soft powder architectures to obtain the next generation bulk permanent magnets with a twofold increase of the (BH)max at room temperature i.e. up to 800 KJ/m3. To achieve this objective we have assembled an experienced multidisciplinary team of physicists, chemists, materials scientists, and engineers to develop these next generation magnets.",HIGH PERFORMANCE NANOSTRUCTURE PERMANENT MAGNETS,FP7,31 December 2012,01 June 2010,202318.0 NANOPHENSIM,Foundation for Theoretical and Computational Physics and Astrophysics,photonics,"The growing realisation of the immense potential for applications of the carbon nanotubes has attracted much attention of scientists. Presently, the nanotube research has become one of the most intensively developing areas of nanotechnology. The principal reason for the amazing electronic and vibrational properties of the nanotubes stems in their quasi-one-dimensionality. The initially existing principal obstacle of normally very large nanotube unit cells, which hindered most of the atomistic simulations on perfect nanotubes, has recently been overcome by using of the screw symmetry of the nanotubes. This allowed for large-scale calculations of phonon dispersion and electronic structure, as well as various optical, thermal, and mechanic properties, of any nanotube of practical interest. The principal objectives of this project are the extension of this symmetry-adapted approach to calculations of other properties and phenomena in nanotubes, which have not been addressed in detail so far. The major topics to be encompassed by the project are: 1) exciton effects, which are of major importance for the optical processes in nanotubes as evidenced by experiments and supported by theoretical arguments, 2) second-order Raman scattering, which can be a source of information for the electronic structure and phonon dispersion of nanotubes but has been described qualitatively only in several limited cases, 3) the phenomenon of photoluminescence, which provides direct information for the structural properties of carbon nanotubes and for the electron (or exciton) -phonon scattering processes, but has not received much attention by theorists, and finally, 4) thermal and electronic transport in nanotubes, which are basic phenomena with importance for building up nano-electronic devices.",COMPUTER SIMULATIONS OF OPTICAL AND TRANSPORT PHENOMENA IN CARBON NANOTUBES,FP7,31 August 2010,01 September 2007,45000.0 NANOPHOSOLAR,Paint Research Association,energy,"The NanoPhoSolar project aims to overcome the limitations relating to the efficiency and performance of a range of photovoltaic (PV) systems by developing a transparent NanoPhosphor down converting material capable of absorbing Ultra Violet (UV) and short wavelength visible light and re-emitting in the more useful longer wavelength visible spectrum(range 525-850nm). This will enable the efficiency of Photovoltaic (PV) cells to be increased by an additional 10% for silicon PV and ≥25.8% for Cigs or cadmium telluride PV and potentially increase system lifetime. By doing this, the PV system created will offer greatly improved environmental performance due to capture of a larger proportion of the incident visible spectrum. This will lead to significant economic and societal benefits to consumers and manufacturers. The SME consortium target a total in-process coating technology market penetration of 5.5% when applied in the manufacturing process and 0.25% when as applied to existing installed PV systems within a 5 year period post project, achieving direct annual sales of over €66 million, ~470 new jobs and annual CO2 emissions savings of 154,697 tonnes per annum. The project results are expected to benefit other SMEs in the PV and materials processing industry sectors.","Innovative, environmentally friendly nanophosphor down converter materials for enhanced solar cell efficiency that will reduce energy production costs and increase cell lifetime.",FP7,31 December 2015,01 January 2013,1928675.0 NANOPHOTO,University of Milano * Università di Milano-Bicocca,energy,"The primary aim of this research project is to develop computational tools capable of assisting the design of a new nc-Si growth process with a Low Energy variant of a Plasma Enhanced Chemical Vapour Deposition (LEPECVD) reactor, addressed at the deposition of nc-Si films for both photovoltaic and optoelectronic applications.This objective is for many aspects really at the frontier of the today knowledge of multiphase materials, and for this reason requires the involvement of different theoretical and experimental tools and expertises. An LEPECVD reactor is actually in full use in one of the partner's laboratories and has been already demonstrated to be a very powerful tool for high growth rate, high quality epitaxial silicon and silicon-germanium films. The modelling activities include Molecular dynamics (MD) and ab-initio calculations applied to the the simulation of the growth of nc-Si grains in a amorphous silicon (a-Si) matrix, to the evaluation of the best a-Si/ nc-Si ratio and the elastic/plastic effects consequent to the presence of nanocrystals of silicon in the a-Si matrix and to the presence of a grain boundary phase, which could be responsible of unwanted carrier recombination processes.The computational tools will be also used to evaluate the band offset vs microstructure and strain, in view of the of the fine-tuning of the optoelectronic properties. As the computer modelling could not be granted for a complete forecasting of the role of process parameters on the local nanostructural aspects and associated physical properties, additional theoretical studies on quantum confinement will be carried out. Such theoretical studies will be based on the results of systematic measurements of optoelectronic properties of nc-Si.The development of the computer modelling will be paralleled from the very beginning by state of the art characterization investigations and by quantum confinement studies.",Nanocrystalline silicon films for photovoltaic and optoelectronic applications,FP6,30 November 2008,01 June 2005,1699954.12 NANOPHOTO,University of Padua * Università degli Studi di Padova,health,"The overall objective of this proposal is the development of one or more nanosystems loaded with Foscan® and conjugated to cancer cell specific ligands for improving the efficacy and selectivity of photodynamic therapy (PDT) and optimise a fluorescence-based tumour imaging approach. At present, PDT with Foscan® can be very effective but is not selective because Foscan® accumulates in the tumour tissue as well as in healthy ones. A great improvement of the therapy can only come from the availability of a carrier able to seek cancer cells and deliver Foscan® selectively to them. Three types of nanosystems, namely, liposomes, silica nanoparticles or poly(lactide-co-glycolide) copolymer nanoparticles, have been selected as potential nanocarriers for the selective delivery of Foscan®. The selection was mainly based on the different chemical nature of these systems, which can affect biocompatibility. During the first part of the project each type of nanosystem will be optimised through in vitro and in vivo tests and leader nanocarriers will be selected and conjugated to cancer cells specific ligands for increasing the selective delivery of Foscan®. The ligands we will use (folic acid, EGF, and antibodies) for targeting the nanosystems find their corresponding receptor over-expressed on the surface of cancer cells, therefore allowing a selective delivery of drugs in these cells. In vitro and in vivo investigations will be carried to demonstrate the validity of our approach and deliver, at project conclusion, a final product which can then be tested clinically. Because of the red fluorescence emitted by Foscan®, once it is selectively accumulated in cancer cells fluorescence based technique can be used for tumour imaging and diagnosis. Therefore we expect to develop a Foscan® loaded nanosystem/s which can be used for improving both therapeutic and tumour imaging approaches.",Targeted Nanosystems for Improving Photodynamic Therapy and Diagnosis of Cancer,FP7,31 December 2011,01 July 2008,2453118.0 NANOPHOTOCHROME,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),health,"Most photosensitive integral membrane proteins (PIMP) are not able to deal with the excess energy of photons from UV to blue region and normally do not absorb them at all. If high-energy photons were absorbed, they might destroy the light-harvesting chromophores or even induce apoptotic-like cell death. Thus, the energy efficiency of green plants is less than 5% and the energy-producing PIMP bacteriorhodopsin (bR) not possessing specific light-harvesting system utilizes less than 0.5% of solar light. Nanotechnology opens the way to increase performances of biological functions. Summarizing the sources of energy losses provides an idea to optimization through the engineering of a built-on-the-membrane light-harvesting antenna from photoluminescent (PL) quantum dots (QDs) which might be able: (1) to harvest light from deep UV to blue region, (2) to convert this energy to photons that can be absorbed by bR or photosynthetic reaction centers (RC) and (3) to transfer this energy to PIMP's chromophores thus improving biological function. The QD is a unique nanomaterial able to absorb a lot of light from UV to visible region and to convert it in the photons of PL in a narrow spectral region determined by their size. NanoPhotoChrome will combine the nanotechnology and genetic engineering, where genetic engineering develops RC and bR variants with biological functions adapted to specific application and nanotechnology develops QDs specifically selected to be optically coupled with the PIMP chromophores and with surfaces functionalized to form complexes with biomembranes or to be chemically tagged with desired amino acid residues of bR or RC. Such optical and spatial coupling will form efficient energy transfer donor (QD)/acceptor (PIMP chromophore) pairs. The PIMP-QDs nano-units operating in the FRET-regime will provide new hybrid materials with improved biological functions with the advantages of efficiency of light-controlled operation, stability and low cost production.",Energy Conversion within the Hybrid Materials Engineered from the Nanocrystals Quantum Dots and Photochromic Membrane Proteins,FP7,31 October 2010,01 June 2009,218731.0 NANOPHOTONIC DEVICES,Hebrew University of Jerusalem,photonics,"We propose the fabrication and optical study of new nanophotonic devices based on composite, highly transparent polymer matrices that incorporate near infrared, light emitting semiconductor nanocrystal quantum dots, on different sub-micron patterned surfaces. The devices will combine the atomic-like optical functionality of the nanocrystal quantum dots and the fabrication flexibility of the polymer host with state-of-the-art Si based and Metallic based nanophotonic platforms, such as sub-micron size Si core and air core waveguides and resonators, and sub-wavelength resonant metallic gratings. The proposed objectives are: (a) Understanding the physical mechanisms that determines the carrier dynamics in those nanocrystal quantum dots and in the nanocrystal-polymer composite. (b) A design, fabrication, and study of new active (light emitting) devices and passive nonlinear devices that are based on such hybrid nanocrystal-polymer matrices on Si based planar nano-patterned waveguide platforms. (c) Fabrication and study of nanocrystal-polymer composites incorporated into subwavelength metallic structures, to understand the coupling of the different types of resonant plasmon modes of the subwavelength metallic structure to the nanocrystal quantum dots, probe the enhanced local fields effect on the linear and nonlinear optical properties of the active composite, and identify the potential of such structures as new photonic devices. The experimental methods will include continuous wave as well as time resolved optical spectroscopy, and high-power ultrafast two beam and three beam pump-probe measurements.",Physics and applications of nanocrystal - polymer nanophotonic devices,FP7,31 December 2011,01 January 2008,100000.0 NANOPHOTONICS4ENERGY,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),energy,"The Nanophotonics for Energy Efficiency proposal aims to create a virtual centre of excellence to re-orient and focus nanophotonics research towards the challenges in energy efficient applications. The network will cluster nanophotonic laboratories and research groups in Europe combining their expertise in the development of disruptive approaches to lighting and solar cell technology. The consortium consolidates know-how and resources of 9 different institutions in 6 European countries with complimentary research and development expertise, integrating more than 130 scientists, engineers, technicians and managers in nanophotonics. The project pursues a scientific bottom-up approach to ensure that novel ideas and scientific breakthroughs as well as established proof-of-concepts in academia are promoted along the value chain towards reaching their eventual goal of commercialization. Market and industrial relevance is ensured through the involvement of industry leaders in the Advisory Board. This approach complements the existing top-down, industry-driven projects like e.g. OLED100.eu. The project intends to achieve the overall long-term integration goal by coordinating three main efforts: 1. Realising a strategy for successful integration: creation of new research clusters and a virtual laboratory network that will lead to the creation of a lasting entity that will exist beyond the duration of this NoE 2. Establishing joint research: foster collaborations among the leading groups in nanophotonics for energy efficiency, interchanging knowledge and best practices, and paving the way towards the establishment of common research agendas 3. Spreading knowledge: education and training specially geared towards young researchers and technicians -both on S&T issues as well as on complementary skills like communication, business, entrepreneurial or IPR skills -and dissemination towards the scientific community, industry, and the public in general",Nanophotonics for Energy Efficiency,FP7,31 March 2015,01 January 2010,2900000.0 NANOPHYS,Institute of Science and Technology Austria,health,"In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches. The goal is to obtain a quantitative nanophysiological picture of signaling in this key type of interneuron. By incorporating realistic BC models into dentate gyrus network models, we will be able to test the contribution of this important type of GABAergic interneuron to complex functions of the dentate gyrus, such as pattern separation, temporal deconvolution, and conversion from grid to place codes. The results may lay the basis for the development of new therapeutic strategies for treatment of diseases of the nervous system, targeting interneurons at subcellularly defined locations.","Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons",FP7,31 May 2016,01 June 2011,2500000.0 NANOPIGMY,Nubiola Pigmentos SL,construction,The change in automobile and construction materials requirements has led industries to the,More than color: Applying nanotechnologies for the multifunctional ceramic pigments development,FP7,02 April 2017,03 January 2012,0.0 NANOPLAST,University of Genoa * Università Degli Studi Di Genova,health,"Every year, millions of tons of plastic litter are reversed into the oceans, washed up on the shores or piled in landfills. There, plastics are degraded down to the micro and nano scale, and enter the food chain. Plastic particles can transport toxic substances, but the effects of micro and nanoplastics themselves on living organisms is still largely unknown. Here we address a key step of this interaction: the interaction of nanoplastics with model biological membranes. We propose a computational study of the interaction between polymers of everyday use and model lipid membranes. Our main goal is to identify possible physical mechanisms of damage to the cell membrane induced by the interaction with plastic nanofragments. Membranes can be altered in many ways: mechanical (membrane rigidity), dynamical (lipid and peptide diffusion) and structural (lipid order, area per lipid, membrane thickness). Even more interestingly, our preliminary results show that hydrophobic polymers such as polystyrene can influence the lateral organization of heterogeneous lipid membranes into ordered (rafts) and disordered domains. These changes are relevant as they can affect the functionality of membrane proteins and other constituents, therefore altering the overall cell functioning. We will study the polymers most commonly found in the marine environment (polypropylene, polyethylene, polyethylene terephthalate, polystyrene…) and model membranes of various compositions. We will model both the polymers and the membranes at a coarse-grained level, relying on the support of detailed all-atom models whenever necessary. Characterizing the interaction of plastic nanoparticles with cell membranes is the first step towards understanding the physical and chemical basis for their toxicity in all living organisms -bacteria, plants and animals. Since plastics are nowadays ubiquitous, the project can have a great impact, on the scientific community worldwide and on the society in general.",A computational study of the interaction between nanoplastic and model biological membranes,FP7,31 July 2016,01 August 2013,75000.0 NANOPOLYTOX,Acondicionamiento Tarrasense Associacion,environment,"The project NANOPOLYTOX will evaluate the toxicological impact of nanomaterials included in polymer nanocomposites, highly used in various industrial sectors, during their life cycle. The toxicological profile will be correlated with the changes in the physical and chemical properties of the nanomaterials during the artificial aging/weathering process of the polymeric nanocomposites. Raw nanomaterials and extracted nanomaterials will be characterized at different stages of their life cycle and their toxicity profiles will be obtained via in vitro and in vivo toxicity studies. The results from the in vivo studies will be used for the evaluation of the biological and environmental fate of nanomaterials. All the data generated during the project (physical, chemical and toxicological data) will be considered for the development of the novel LCIA methodology to apply to nanomaterials. These studies will also be taken into account for the selection of adequate digestion and extraction methods to separate the nanomaterials from the polymeric matrices. Moreover, optimization of these methods will facilitate the development of recycling techniques that will be applied in the end-stage of polymer nanocomposites. Disposal of the extracted toxic and/or innocuous nanomaterials will be carried out by mechanical and chemical recycling techniques. The chemical recycling technique will be based on a new separation method consisting of nanofiber filters to separate efficiently the raw nanomaterials from the polymeric matrices and re-use them in new applications. Finally, the nanofiber filters containing toxic nanomaterials will be immobilized in xerogel matrices by sol-gel processes and sintering.","Toxicological impact of nanomaterials derived from processing, weathering and recycling of polymer nanocomposites used in various industrial applications",FP7,05 July 2015,05 January 2010,2433555.07 NANOPORATION,University of Dundee,health,"Clinical drug delivery (DD) remains a problem of heightened industrial and academic interest. The proposed partnership seeks to embrace the problem by exploiting the unique expertise-base spanning the industrial research and academic pratners. We will provide inter-sectoral training of mulit-disciplinary researchers and create a novel new DD modality that addresses the key critical needs for non-invasive therapy via intelligent generic targeting and with intrinsic flexibility in drug choice. An essential simplicity to the present approach is that it takes strands of intrinsically safe technologies, and marries these into a powerful amalgam that offers true power and enhanced versatility. Chief amongst the areas of research are: (i) A generic encapsulating technology [CapsuTech - industrial partner] that will vector active anti-cancer drugs to a tumour target; (ii) Remotely triggered drug release on demand by externally focused ultrasound energy [development by industrial partner Insightec](iii) Enhanced drug uptake through the parallel disruption of cell membranes by the action of ultrasound on commercially available microscopic bubbles [sonoporation - University of Dundee]. The Dundee Group, who will lead this partnership, has made significant inroads to fundamental understanding with this latter strand. Moreover, the partners have gone to great lengths to factor in a level of training that also embraces existing trends for image guided intervention: in particular with magnetic resonance imaging (MRI). The project objectives we have realized are fully compatible with MRI technology and indeed, this prescience endows the overall scheme with significant added value. We anticipate that this synergistic and intra-sectoral multi-disciplinary research partnership will create significant momentum, enduring relationships, visionary researchers and a roadmap towards significant European market share, as well as delivering on truly excellent scientific objectives.",Ultrasound activiated nanoencapsulated targetted drug delivery and tumous cell poration,FP7,30 April 2013,01 May 2009,2071718.0 NANOPOROUSVIP,Arcelik AS,construction,"Vacuum insulation panels (VIPs) offer extremely high thermal resistances properties combined with small thickness that can enhance the energy efficiency of the insulating systems and provide savings in energy consumption. They are generally made with porous core materials wrapped, under vacuum, in airtight films. In the construction of VIP, core materials play a crucial role in thermal performance and mechanical properties of the insulation system. Commonly used core material is fumed silica with nanoporous structure. Core materials with higher porosity and smaller pore size have the greater ability to maintain lower thermal conductivity. However, high product costs are the main obstacle for a broader penetration of the VIPs technology into many applications like cold appliances and building insulations. The main objective of the proposal is to develop cost effective novel nanoporous core materials that can be used as core insulation filler in VIPs, which will help for the widespread usage of this technology for applications in cold appliances and/or building insulations. The nanoporous inorganic materials will be developed using triblock self-assembled polymers (Pluronic® F127) as structure directing compounds. Pluronic forms nano-size micelles and have polar OH end groups that when assembled as a surface can provide slightly negatively charged sites for nucleation of the inorganic phase. After the coating of the nano-size polymeric micelles with the inorganic phase, a porous structure will be obtained when the polymer is removed from the inorganic-polymer composite by calcination. Then, VIP prototypes will be produced with the developed porous core materials and thermal performance at the different vacuum levels will be measured. It is aimed to develop VIP with thermal conductivity of less than 4 mW/m.K. The refrigerator prototypes will also be produced by the integration of the VIPs and various tests with regard to performance and heat losses will be performed.",DEVELOPMENT OF NANO-POROUS MATERIALS FOR THE PRODUCTION OF VACUUM INSULATION PANELS (VIPs),FP7,02 May 2018,03 January 2012,100000.0 NANOPOTS,University of Cambridge,photonics,"The target of this project is to develop a new class of polymer based optoelectronic devices embedding the optical and electronic functionalities of carbon nanotubes (CNTs). These devices will combine the fabrication advantages of polymer photonics, with the tunable active and passive optical properties of CNTs. This is an ambitious frontier research program, with a strong interdisciplinary nature, across engineering, physical, chemical and soft matter sciences. The ERC grant will consolidate the newly funded Research Group lead by the PI at the newly built centre for Advanced Photonics and Electronics of the University of Cambridge. CNTs will be grown by chemical vapour deposition at low temperatures, compatible with polymer processing. Direct deposition of CNT on optical components (such as fibres and mirrors) will be studied. Fundamental understanding of ultra-fast non-linear optics will be sought by a combination of theory and experiments. A range of novel photonic polymers incorporating CNTs will be produced: index matching gels, optical adhesives and silicones. These new materials, incorporating the optical functionality of CNTs, will be used to build a variety of photonic devices. Nanowires are also promising for photonic applications, since they exhibit a size-tunable absorption resonance at telecommunications wavelengths, and their use will also be considered.",Nanotube Based Polymer Optoelectronics,FP7,30 September 2013,01 October 2008,1799964.0 NANOPOWER,University of Perugia * Università degli Studi di Perugia,information and communications technology,"Nanoscale energy management is a new, exciting field that is gaining increasing importance with the realization that a new generation of micro-to-nanoscale devices aimed at sensing, processing, actuating and communication will not be possible without solving the powering issue. The scientific objective of this project is thus to study energy efficiency with the specific aim of identifying new directions for energy-harvesting technologies at the nanometre and molecular scale. The technological objective of the project is to integrate such technologies into autonomous nanoscale systems to allow new, low-power ICT architectures to find their way into devices. In a joint effort, the nanopower consortium composed by world leading experts in the fabrication of Si and III-V semiconductor nanodevices, fundamental and applied modelling as well as design and integration of ICT architectures will fabricate, test and evaluate new conception devices: “nanomechanical nonlinear oscillators”, “phonon rectifiers” and “quantum harvesters” addressing applied prototypes and non-equilibrium processes down to the quantum level.",Nanoscale energy management for powering ICT devices,FP7,07 July 2015,08 January 2010,2629277.0 NANOPRIM,Research Center Fiat * Centro Recherche Fiat (CRF) SCPA,transport,"The present project aims at developing an on-line gas phase nano particle measurement tool that can be used for various manufacturing processes in the nano-technology domain. Specifically, within NANOPRIM, the particle sizing measurement apparatus will be designed, developed and then integrated into a unique nanoparticle deposition process of nanocrystalline layers for the fabrication of novel catalytic sensors. These sensors were demonstrated to have a high sensitivity in detecting gas, but with the current end-of-line measurement of the ready deposited layer, the response is ambiguous and the layer is vulnerable to aggregation. The characterisation tool will enable a radical improvement of the deposition process because none of the state of the art methods and tools are nowadays able to measure gas phase particles of 5-20nm size, even in case of low-density. This improvement will led to many applications among which applications in the automotive industry, as defined by FIAT RC, member of this consortium. This project will explore a new frontier of knowledge by: -understanding and controlling the fundamental mechanisms underlying the growth and the dynamics of nanoparticles in the gas phase by characterizing cluster beams with optical methods. -integrating two different and complementary methodological approaches (aerosol and cluster beams), under precise on-line monitoring, to attain a fundamental understanding of the mechanisms of production, modification, manipulation of nanoparticles in the gas phase. Long term innovation will be promoted by the development and implementation of a ground-breaking enabling technology based on gas phase nanoparticle integration in different manufacturing processes that are necessary for a wide range of industries in the product manufacturing domain.",Advanced measurement tool for nano particles size in deposition processing,FP6,30 June 2009,01 July 2006,1549908.0 NANOPUR,Flemish Institute for Technological Research * Vlaamse Instelling voor Technologisch Onderzoek (VITO),environment,The NANOPUR-project aims at leveraging on promising bottom-up technologies to develop intensified water treatment concepts based on nano-structured and nano-functionalized membranes as well as nanofilm deposition for micropollutants and virus removal.,Development of functionalized nanostructured polymeric membranes and related manufacturing processes for water purification,FP7,04 June 2017,05 January 2012,0.0 NANOPUZZLE,University of Zaragoza * Universidad de Zaragoza,health,"Nature has been utilizing nanostructures for billion of years. The following two properties, (i) being about the size of typical biological objects and (ii) the possibility of tailoring their properties by changing their size, make nanoparticles attractive for biomedical applications. Using nanoparticles to deliver drugs to tumours offers an attractive possibility to avoid obstacles that occur during conventional systemic drug administration. This NANOPUZZLE project pretends to develop an innovative controlled release methodology, based on hyperthermia and magnetic nanoparticles, as platform for the incorporation of different molecules with different functionalities, to obtain a multifunctional system for cancer treatment and diagnose that leads antitumoral drugs discharge only in the tumoral area. Multifunctional magnetic nanoparticles loaded with a targeting agent (folic acid) and a potent antitumoral drug (doxorubicin) will be prepared. These active molecules will be coupled to the magnetic nanoparticles (MNPs) due to complementary oligonucleotides strands (oligo-zipper). Due to the magnetic properties of these nanomaterials, a local heating induced by an alternating magnetic field, will release the drug in the desired target as a consequence of the DNA denaturation (oligo-unzipping). For this approach, the increase of temperature is only required directly in the nanoparticles and the heating of the surroundings is not needed. For instance, less quantity of nanoparticles and a weaker external magnetic field will be required, avoiding the main inconveniences of conventional hyperthermia treatments. Furthermore, the superparamagnetic properties of these MNPs will also allow their use as contrast agents for tracking and diagnosis by magnetic resonance imaging (MRI).",Multifunctional Magnetic Nanoparticles: Towards Smart Drugs Design.,FP7,31 December 2015,01 February 2010,1541310.0 NANOPUZZLES,University of Gdansk * Uniwersytet Gdański,health,"Nanotechnology is rapidly expanding. However, some types of engineered nanoparticles can be toxic for living organisms and exhibit negative impact on the environment. Thus, the design of new nanomaterials must be supported by a rigorous risk analysis. Following the recommendations by the EU REACH system and regarding ethical aspects, the risk assessment procedures should be performed with possible reduction of living animal use. The main objective of the NanoPuzzles project is to create new computational methods for comprehensive modelling the relationships between the structure, properties, molecular interactions and toxicity of engineered nanoparticles. The methods will be based on the Quantitative Structure - Activity Relationship approach, chemical category formation and read-across techniques. Those methods have been widely used in risk assessment of other groups of priority chemicals. But, because of some specific reasons, they can not be applied directly to nanoparticles. We will be developing novel methods within four complimentary areas ('puzzles'), namely: (i) evaluation of physico-chemical and toxicological data available for nanoparticles (NanoDATA), (ii) developing novel descriptors of nanoparticles' structure (NanoDESC), (iii) investigating interactions of nanoparticles with biological systems (NanoINTER), and (iv) quantitative structure - activity relationships modelling (NanoQSAR). Developed methods will be tested and verified for their technical viability by the collaborating industry representative. By implementing the NanoPuzzles methods, extensive animal testing would be significantly reduced. Moreover, the project will deliver the basis for categorising nanoparticles based on potential exposure, phys-chem, structural and toxicological properties. To maximise its impact, the project is going to cooperate with ModNanoTox, NanoTransKinetics, NanoSafety Cluster and NanoMedicine ETP.","Modelling properties, interactions, toxicity and environmental behaviour of engineered nanoparticles",FP7,31 December 2015,01 January 2013,976810.0 NANOPV,Stiftelsen for Industriell og Teknisk Forskning (SINTEF),energy,"The NanoPV project aims at making a breakthrough step-change in photovoltaics by the removal of a set of bottlenecks which have been identified to block the application of nanostructures for high-efficiency, low-cost solar cells. The bottlenecks arise from the present lack of up-scalable processes that can meet the needs for nanomaterials in PV applications, and the lack of relevant equipment and industrial lines. In order to remove these bottlenecks, the main objectives of NanoPV are: 1) To develop technologies that can increase the efficiency and reduce the processing cost of existing silicon solar cell technologies using nano-scale effects provided by nanomaterials to above 20% for wafer based and above 15 % for thin film silicon based solar cells at a processing cost for modules well below 1 €/watt. 2) To design and to fabricate low cost solar cells entirely from nanomaterials by using nanostructures. An efficiency of above 10 % at processing costs well below 1 €/watt is targeted with potential of further significant improvements in the future. 3) To develop up-scalable cost effective processes and equipment in order to implement both enhanced standard solar cells and solar cell based on nanomaterials as well as related modules to existing pilot lines. 4) To create new market opportunities for the industrial partners. Nanotechnology will be applied for both already existing conventional Si solar cells (wafer and thin-film based) and for advanced solar cells entirely based on nanostructures. The main scientific efforts will be on understanding and exploitation of such nanomaterials as i) 0D quantum dots, nanocrystals and nanoparticles, ii) 1D nanowires and nanorods, and iii) 2D nanomaterials such as ultrathin layers. A large number of specialised technologies will be applied in the project. Therefore, in order to ensure successful completion, a comparatively large consortium of 9 complementary research partners and 3 industries has been assembled.",Nanomaterials and nanotechnology for advanced photovoltaics,FP7,28 February 2014,01 March 2011,3853315.0 NANOPV,University of the Basque Country * Universidad del País Vasco / Euskal Herriko Unibertsitatea,energy,"Engineering of cheap nanoscale elements based on self-assembled organic molecular materials with spatially distributed p-n interfaces is envisaged as a promising alternative to the expensive inorganic photovoltaic cells. In this frame, we plan to explore nanophotovoltaic interfaces to advance our understanding of the processes of sunlight conversion into usable electrical energy in molecular-scale structures. Of particular relevance for the working principle of solar cells are the interfaces between n- and p-type semiconductors, as well as those between the semiconductors and metallic contacts. We will address 3 main types of model systems: (i) bicomponent molecular layers comprising both donor and acceptor semiconducting molecules, (ii) single molecules featuring covalently coupled but yet differentiated donor and acceptor moieties, and (iii) donor-acceptor networks resulting from surface supported polymerization of previously assembled appropriate precursors. As substrates we will use the bare surface of atomically clean single crystal metals, as well as an isolating buffer layer grown on top to decouple the molecules from the metal. The functionality of such interfaces strongly depends on their electronic properties, and also on their crystalline structure and morphology. A combination of STM and STS measurements will provide not only a thorough structural analysis of the systems under study, but also detailed and spatially resolved spectroscopic insight of the relevant interfaces. Furthermore, complementary spatially averaging photoelectron and NEXAFS spectroscopies, as well as DFT calculations, will complete our study. Such study of the electronic structure of all these systems, put in relation with their simultaneously measured spatial arrangement, is expected to give valuable insight into the underlying physics of nano-photovoltaic interfaces, and thereby allow for the design and synthesis of functional interfaces with optimized optoelectronic response.",Spectroscopic insight with nanoscale resolution on model photovoltaic systems,FP7,01 May 2014,02 May 2011,230027.0 NANOQUANT,Royal Institute of Technology * Kungliga Tekniska Högskolan,photonics,"The purpose of NANOQUANT is to fund a coherent European effort towards the
development of the basic theory and methodology of quantum modelling of
nanomaterials, establishing a world-leading European expertise in the area. Its
scientific objective is the development of linear-scaling density-functional
techniques and reduced-scaling wave-function techniques for the calculation of
energies and properties of large systems, greatly extending the application range
of quantum-chemistry methods. In the process, we foresee several spin-offs with
benefits at the European level. First, the proposed network will produce cutting-
edge modelling software, serving as an excellent vehicle for the transfer of
knowledge to thousands of young European researchers. Second, the network will
provide first-class trainees prepared to aid the development in nanoscience, a
prioritized European research area. Third, it will produce research results that
provide added values in the European Research Area in nanoscience - in particular,
in the areas of molecular/nano-photonics, molecular/nano-electronics, and the
modelling of characterization research.
The training of early-stage and experienced researchers is a central objective of
the network. The minimum total planned training to be financed by the contract is
348 man-months. Apart from educating young researchers, the aim of the network is
to promote the general skills in scientific computing and materials science, as
well as the ability to work in a research environment. Four schools organized by
the partners are integral to the training, in addition, training is presented
through a set of internet tutorials and a "coherence-of-training" program.
Participation in workshops, meetings, and seminars are also scheduled. Geographic
flexibility is promoted through a twinning program, in which the trainees will work
at more than one node.
NANOQUANT is deeply rooted in long-term coopera",Understanding Nano-Materials From the Quantum Perspective,FP6,31 March 2007,01 April 2004,1780564.0 NANOQUANT,Vienna University of Technology * Technische Universität Wien,information and communications technology,"We propose to establish nanofiber-based atom-light interfaces as quantum-enabled fiber-optical components for quantum information processing and communication (QIPC). The key ingredient of this interface is a nanofiber-based optical dipole trap which stores laser-cooled atoms in the evanescent field surrounding the nanofiber. In this evanescently coupled atom-waveguide-system, even a few hundred atoms are already optically dense for near-resonant photons propagating through the nanofiber. In combination with the proven good coherence properties of nanofiber-trapped atoms, these highly efficient light-matter interfaces are thus perfectly suited for the implementation of practical QIPC devices. More specifically, the first goal of this project is to realize quantum memories which allow one to directly store and retrieve the quantum state of fiber-guided photons. The efficiency of the retrieval process will highly benefit from the fact that conservation of energy and momentum stabilizes the emission of the stored light into the nanofiber-guided mode. Furthermore, nanofiber-coupled atomic ensembles can provide a strong optical non-linearity which, due to the waveguide-geometry, scales with the square root of the length of the sample and can be much larger than for freely propagating light beams. The second goal of this project is to explore and to maximize this non-linearity until it prevails down to the single photon level. This single-photon non-linearity would enable optical quantum switches and photon-photon quantum gates which are essential for implementing deterministic optical quantum computation. The final goal is then to interconnect these components in order to demonstrate three different fiber-optical quantum network applications: highly efficient photon counting using fiber-coupled quantum memories, highly efficient heralded entanglement of two fiber-coupled quantum memories, and a non-linear interaction between two single-photon pulses.",Nanofiber Quantum Networks,FP7,05 July 2021,06 January 2014,1993526.0 NANOQUANTUMDEVICES,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,health,"The investigation of the transport properties of nanoscaled objects is a strongly expanding field of nowadays solid-state physics, it attracts increasing attention either in applied science due to the potential in future applications or in basics research due to exciting quantum effects on the nanoscale. Semiconducting nanowires (NW) are single crystals with a typical diameter of 10-100nm and length of 5-10microm. Fabricating metallic leads to NWs, devices can be produced, where the electron density can be strongly varied by gates and the transport can be explored from the quasi-ballistic to the quantum dot regime. Due to their exceptional properties (e.g. band structure engineering, possibility to contact them with ferromagnetic (F), superconducting (S) leads, local gating), NW based devices open a new horizon in quantum transport. In order to be competitive in the field of experimental quantum electronics, it is essential to own sample fabrication facilities, which has not been available in the host institute. The main aim of this proposal is to set up the environment of device fabrication, which will be based on a Jeol scanning electron microscope equipped with lithography unit. The applicant will fabricate and investigate the low temperature transport properties of InAs NW based devices focusing mainly on spin injection from ferromagnetic leads and on F-S hybrid nanostructures. The fabrication facility will also support other ongoing quantum electronic projects.",Fabrication and Electron Transport Study of Nanowire based Quantum Devices,FP7,31 March 2012,01 April 2009,45000.0 NANOQUENCH,Polytechnic University of Catalonia * Universitat Politècnica de Catalunya,health,"NanoQuench project is about the development of alternative methods to coat indewelling medical devices to control microbial biofilms with relevance to clinical drug resistance. Biofilms are bacterial communities embedded in a self-produced polymeric matrix that commonly grow on indwelling medical devices, such as catheters. This mode of growing is believed to be regulated by a quorum-sensing (QS) system, a unique mechanism of communication that bacterial cells use through the secretion and uptake of small hormone-like molecules, called autoinducers. Due to their innate resistance to the immune system and low susceptibility to antibiotics, the microbial biofilms are difficult to treat and are a major factor in the morbidity and mortality of most infectious diseases. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore needed. Technologies that avoid catheter biofilm formation are based mainly on the application of conventional antimicrobial agents. However, the high resistance of bacteria within the biofilm makes any single therapeutic intervention unlikely to have sufficient effect. This project focuses on the development of an integrated technological platform comprising quorum quenching enzymes and novel antibacterial agents (nanoantibiotics), able to counteract biofilm formation and at the same time avoid development of bacterial resistance to the therapy. These functional compounds will be coated onto catheters via layer-by-layer technique or a novel ultrasonic process.",Novel coatings to prevent biofilm formation on urinary catheters based on nanoantibiotics and quorum quenching compounds,FP7,24 March 2015,25 March 2013,166336.0 NANOQUESTFIT,University of Vienna * Universität Wien,information and communications technology,"Quantum phenomena are an important basis for future information processing and information acquisition technologies. They will become particularly relevant for quantum-enhanced metrology and advanced sensors, which exploit the quantum superposition principle at a mesoscopic scale.",Nanoparticles in Quantum Experiments: Exploring the scientific basis of future innovative quantum technologies,FP7,12 July 2017,01 January 2013,0.0 NANOQUIS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),photonics,"The growth of classical computational power supported by continued size reduction is expected to find its limit around 2019, when devices will probe the atomic scale. Fortunately, this limit represents an opportunity as systems are ruled by quantum mechanics that may lead to more efficient computation techniques. Many systems have been proposed as candidates to implement quantum computers: trapped ions or cavity and circuit QED,... However, still none of them has emerged as a definite full-fledged and scalable quantum computer. The shortcomings imposed by classical computation appear to be especially critical when studying quantum mechanical systems, since the computational complexity increases exponentially with the system size. To deal with the intrinsic computational complexity of quantum mechanics, without recurring to quantum computation, Feynmann proposed to use quantum systems, already ruled by quantum laws, as analog quantum simulators. In this project, NanoQuIS (Nanophotonics for Quantum Information and Simulation), the applicant will study the possibilities for quantum information and simulation of one promising emergent platform, namely, atoms interfaced by photonic crystals. First, within a semiclassical framework, dielectric structures in one and two dimensions will be designed in order to trap atoms and induce special interactions between them. Then, it will be explored the different hamiltonians and open dissipative evolutions that can be engineered within these structures, to use them for both quantum information and simulation. Particular emphasis will be made in models with long-range interaction, e.g., quantum chemistry problems, due to their important practical implications. Together with the theoretical effort, the proposal aims at creating close collaborations with experimentalists in order to implement the first realizations of the proposed structures.",Nanophotonics for Quantum Information and Simulation,FP7,31 January 2017,01 February 2015,168794.0 NANOR 2BDLW,Istituto Italiano di Tecnologia (IIT),health,"Two-photon direct laser writing (DLW) lithography is a powerful tool to fabricate 3D structures with feature sizes of ~100 nm. This technique is based on the quadratic dependence of the absorption of near-infrared (NIR) light (two-photon absorption, 2PA) by molecules called photoinitiators which trigger the photopolymerization of curable resins. With the aim of downsizing the structures to the nanometer resolution, a requirement of the microelectronics industry, a new strategy has been added to the DLW lithography, the two-beam approach (excitation and inhibition beams) based on the reversible saturable optical fluorescence transition (RESOLFT) concept. This approach is borrowed from the field of super-resolution fluorescence microscopy and consists in the reversible depletion of some intermediate excited state of the photoinitiators only at some specific areas of the point spread function (PSF) of the excitation beam. The objective of this project is to further develop the two-beam DLW lithography to make it more competitive compared to other advanced nanofabrication techniques. The project is conducted to overcome the limitations of the two-beam DLW lithography: 1) the large feature size, the state-of-the-art has recently been pushed to 9 nm line width from a previous value of 55 nm, and 2) the large spatial resolution (Abbe´s resolution limit) due to the so-called 'memory effect', this value always exceeds 2–5 times the feature size, with a lowest value of 52 nm. The approach is based on the investigation of the photophysics and photochemistry involved in the photopolymerization by means of the ultrafast transient absorption spectroscopy to shed some light on the inhibition processes. The expected results are the decrease of the actual size of the written features to the real nanometer resolution, ~1 nm and even more important to reduce the minimal distance of two adjacent yet separated lines (spatial resolution) to the same order of the feature size.",Nanometer Resolution in Two-Beam Direct Laser Writing Lithography,FP7,28 February 2018,01 March 2014,100000.0 NANORADAM,University of Potsdam * Universität Potsdam,health,"In cancer radiation therapy predetermined doses of high-energy radiation are administered to reduce tumours. More than 60 % of the patients diagnosed with cancer are treated with radiation therapy. A detailed understanding of the fundamental mechanisms of DNA radiation damage is of utmost importance with respect to the question of how the damage can be increased by therapeutics used in radiation therapy. On a molecular level a large extent of the cell damage is ascribed to the production of secondary low-energy electrons along the high-energy radiation track that induce DNA single and double strand breaks. The physico-chemical mechanisms of DNA radiation damage can currently only be described for idealized small model systems and it is not known, which DNA nucleotide sequences and higher-order DNA structures are most susceptible to damage. Very recent ground-breaking advances in DNA nanotechnology allow for the first time the detailed study of the interaction of radiation with complex DNA structures. With an innovative DNA origami technique it is possible to map the radiation damage of different DNA target structures with unprecedented efficiency and accuracy. A two-dimensional DNA origami template functionalized with protruding well-defined DNA structures will be exposed to a beam of low-energy electrons. The strand break yield of different nucleotide sequences will be determined as a function of the electron energy using the DNA origami technique combined with atomic force microscopy. Furthermore, the DNA origami technique allows for the study of the influence of an aqueous environment on the DNA strand break yield. The final goal is to identify the DNA target structures that can be most efficiently sensitized to low-energy electrons by radiosensitizers. This fundamental knowledge will have important implications for the development of novel therapeutics and the improvement of radiation cancer therapy.",Probing DNA Radiation Damage by DNA Nanotechnology,FP7,31 March 2017,01 April 2013,100000.0 NANOREAL,Technical University of Munich * Technische Universität München,energy,"Is it possible to really 'see' how fast electrons flow in nanoscale optoelectronic circuits? Can we, in this way, get a complete understanding of the real-time dynamics of electrons in nanoscale circuits? The vision of this ERC proposal is to establish a research area at the interface of condensed matter physics, ultrafast optics, and electrical engineering which has so far been nearly completely unexplored: the investigation of real-time dynamics of photoexcited charge carriers in electrically contacted nanosystems with the highest precision possible. By doing so, unique information about the optoelectronic processes in nanoscale circuits shall be obtained. Four interconnected visions are pursued all with applications in information technology and electrical engineering. The approach is risky, however, it promises very interesting physics on the way. We will: (i) explore the fastest and smallest photoswitches fully integrated in electric circuits, (ii) probe single and collective charge excitations for the fastest nanoscale optoelectronic devices, (iii) determine the radiative and non-radiative lifetimes in photovoltaic circuits time-resolved, (iv) discover how fast nanoscale photo-thermoelectric devices operate. Towards these visions, I propose to use a real-time optoelectronic 'on-chip' detection scheme for nanoscale circuits, which was developed by us very recently. In this setup, I intend to carry out time-of-flight experiments of photoexcited electrons in nanoscale circuits, to investigate the ultimate switching speed of optoelectronic devices, and to explore the ultrafast dynamics of photothermo-electric currents in electrically contacted nanosystems. The project gives essential insights for designing and implementing nanoscale circuits into optoelectronic switches, photodetectors, solar cells, thermo-electric devices as well as high-speed off-chip/on-chip communication modules to make ultrafast nanoscale optoelectronics real.",Real-time nanoscale optoelectronics,FP7,31 October 2017,01 November 2012,1272196.0 NANOREG,Ministerie van Infrastructuur en Milieu * Ministry of Infrastructure and the Environment,environment,"The innovative and economic potential of Manufactured Nano Materials (MNMs) is threatened by a limited understanding of the related EHS issues. While toxicity data is continuously becoming available, the relevance to regulators is often unclear or unproven. The shrinking time to market of new MNM drives the need for urgent action by regulators. NANoREG is the first FP7 project to deliver the answers needed by regulators and legislators on EHS by linking them to a scientific evaluation of data and test methods.",A common European approach to the regulatory testing of nanomaterials,FP7,08 July 2018,03 January 2013,0.0 NANOREM,University of Stuttgart * Universität Stuttgart,environment,NANOREM is designed to unlock the potential of nanoremediation and so support both the appropriate use of nanotechnology in restoring land and aquifer resources and the development of the knowledge-based economy at a world leading level for the benefit of a wide range of users in the EU environmental sector.,Taking Nanotechnological Remediation Processes from Lab Scale to End User Applications for the Restoration of a Clean Environment,FP7,01 July 2019,02 January 2013,0.0 NANORESISTANCE,"EPOS-Iasis Research and Development, Ltd.",health,"NANORESISTANCE introduces for the first time (i) receptor -independent targeting of Epidermal Growth Factor Receptor-kinase activity, (ii) nuclear delivery of anti-Epidermal Growth Factor Receptor therapy with novel grafting techniques and (iii) the deciphering of resistance and lack of responsiveness to anti-EGFR therapies in the preclinical setting with mathematical models of interstitial biodistribution. This work defines an unprecedented integrated approach for the comprehensive management of failure to anti-EGFR therapy and treatment monitoring. This partnership will play a structuring role by allowing researchers to acquire key skills equally relevant to the public and private sectors including cutting edge nanobiotechnology techniques for fabrication of nanotheranostic conjugates for targeted nuclear drug delivery and imaging, pioneering approaches for intracellular targeting with carbon nanotubes (CNT), innovative mathematical models and assessment of biodistribution, state-of-the-art Surface Plasmon Resonance for assessing drug-target interactions, emerging technologies for in vivo protein-protein and theranostic compound-protein interaction with Bimolecular Fluorescence Complementation Assays (BIFCs).These parallel approaches provide a promising innovative solution in the multifaceted challenge of the overall resistance to anti-EGFR therapies. This will be achieved with the development of multimodal CNT-based nanoplatforms carrying the fluorescent conjugates of EGFR inhibitors intracellularly independenly of EGFR extracellular recognition. This system will further deliver anti-EGFR and fluorescent attributes to the nucleus. The partnership offers and a well-structured scheme of complementary skills highly inspired by the entrepreneurial spirit of academicians and research commitment of the industrial partners securing significant impact on their employability in their sector.",Management of Resistance to Tyrosine Kinase Inhibitors with Advanced Nanosystems,FP7,31 October 2015,01 November 2011,1410405.0 NANORETOX,Natural History Museum,environment,"NanoReTox will identify the potential risks to the environment and human health posed by free engineered (i.e. manmade) nanomaterial by comprehensively addressing five key questions: (1) How does the environment into which nanoparticles are released affect their physicochemical properties and their bioreactivity? (2) How does this impact on their ability to interact with and/or penetrate mammalian and aquatic cells and organisms (bioavailability) and will bioavailability result in toxicity? (3) Is there a pattern of cellular reactivity and/or toxicity related to physicochemical properties, i.e. a hierarchy of activity? (4) What combination of conditions discovered in (1-3) above are most likely to pose a risk to human health and the environment? (5) How can this information be incorporated in a risk assessment model? We have assembled a team of experts from across the EU and the US whose combined expertise can address these questions in depth, and therefore comprehensively cover the scope of research topic NMP-2007-1.3-2 – Risk assessment of engineered nanoparticles on health and the environment.",THE REACTIVITY AND TOXICITY OF ENGINEERED NANOPARTICLES: RISKS TO THE ENVIRONMENT AND HUMAN HEALTH,FP7,11 June 2014,12 January 2008,3191900.0 NANORF,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"The aim of NANORF is to take advantage of the unique mechanical and electrical properties of Carbon Nanotubes (as RF NEMS) to hybridize with CMOS electronics for RF applications (1-5GHz). The project main targets are: (i) Prospects concerning the figures of merit of CNTs as NEMS individual devices or/and as arrays (bundles) with particular focus on the following device architectures: nano-switches, nano-resonators using vertical or lateral individual and/or arrays of CNTs, tuneable varactors based on arrays of CNTs; (ii) Develop technological pathways for carbon nanotube radio frequency electromechanical devices: modification/modulation of electrical conductivity under actuation, mechanical and electrical fundamental properties over large of temperature (from cryogenic to 200�C); (iii) Develop hybrid CNT-CMOS technology based on dedicated effort for mastering compatibility issues between silicon CMOS and Multi-Walled Carbon Nanotubes (thermal budget, drift of characteristics induced by complementary technology); (iv) Propose new RF NEMS design using individual CNT and vertically and/or laterally grown arrays of CNTs in precise locations on silicon wafers; (v) Prospect on issues of hybrid CNT-CMOS RF device and IC co-design: coupling to electrodes, dimension control at nano-scale, signal-to-noise ratio, temperature drift; (vi) Build RF hybrid CNT-CMOS circuit demonstrators: filters and oscillators (in general, tuneable RF NEMS blocks relevant for the RF front-end for future mobile communications systems). The proposal essentially extends the performance and functionality of standard silicon RF CMOS ICs based on hybridization with one of the most promising nanotechnologies, the Carbon Nanotubes.",Hybrid Carbon Nanotube - CMOS RF Microsystems,FP6,31 December 2009,31 December 2005,3200000.0 NANORING,University of Oxford,information and communications technology,"This project will explore the synthesis and properties of fully pi-conjugated molecular nanorings with diameters of 3-5 nm. These covalent rings of molecular wire will be constructed from porphyrin and alkyne units, via non-covalent supramolecular assembly on wheel-shaped templates. Their highly delocalized electronic structures are expected to result in unusual optical and magnetic behavior. The photophysical and light-harvesting behavior of the nanorings are expected to mimic natural light-harvesting photosynthetic chlorophyll arrays. Physicists have long been fascinated by the persistent ring-currents and quantized magnetization observed in small loops of wire; it is important to discover whether similar effects can be observed in molecular nanorings. The synthesis of these wire rings could herald the development of molecular solenoids and induction coils with unusual optical and magnetic characteristics, leading to applications in nanoelectronics and nonlinear optics. This project will extend the researcher's experience of organic synthesis, large delocalized chromophores and near-infrared dyes, while introducing him to the latest developments in template-directed synthesis, ESR spectroscopy and ultra-fast photophysics through established collaborations involving the host research group.",Pi-Conjugated Porphyrin Nanorings,FP7,02 May 2014,03 January 2011,200049.6 NANOROADMAP,Italian Association for Industrial Research * Associazione Italiana per la Ricerca Industriale (AIRI),health,"The primary objective of NANOROADMAP (NNRM) is to produce roadmaps for the application of nanotechnology in three industrial fields (materials, health and medical systems and energy) that will cover the next ten years. The project, in complete agreement with the priorities set for FP6, will proceed along a path that will be time and cost effective. In the first 8 months NNRM will collect all the documentation relevant for the preparation of a road map that has been published on nanotechnology in the last few years to distils the general scenario to start with. From this scenario the Consortium will select within each of the three above said fields the most important (2- 4) themes 'golden' to focus on, together with 1-2 more themes, also of high interest, but of lesser importance 'silver'. The 'golden' themes will be investigated in great detail with extensive face-to-face communication through working groups, Delphi panels, conferences and (web-enabled) fora. For the 'silver' themes, on the contrary, a fully web-integrated roadmapping methodology and tool-set will be used. This methodology, though somehow less thorough, is quite more cost-effective and therefore by combining the two approaches NNRM will deliver a road map that cover not only the main themes, but also those of second level, at a reduced cost. In total 12 applications will be investigated. The assessment will focus on drivers of change, scientific and technical challenges and barriers, market demands and funding needs, R&D strategies, infrastructures relevant for research and application of nanotechnologies, social and ethical issues. Dissemination, discussion and feedback of the results is a crucial part of the project. This will be done capillary by all the partners. With specific web sites, distribution of documents, articles and release in the press, direct contacts and, in particular, with the organisation of 2 International Symposia and 8 National Conference.","Technological roadmaps till 2014 in nanoscience and nanotechnologies in materials, health and medical systems, energy fields",FP6,30 June 2006,01 January 2004,650000.0 NANOS.BIT,University of Oxford,information and communications technology,"At present, copper is the material of choice in the current processing technology for advanced semiconductor devices interconnects. However, the high diffusion rate between copper and silicon or silicon oxides requires the development of physical barriers to prevent interdiffusion across the interfaces. The thickness of the currently used barriers makes them an unviable option as the semiconductor industry moves from the 45 nm node to 32 nm and beyond, and alternative approaches are required. Some groups have proposed the use of the so called self-forming barriers, which have the potential to overcome the shortcomings of the current approaches. The aim of this project is to characterize and understand the formation of self-forming diffusion barriers layers for transistor interconnects and to optimize the creation process for future generations of device technology, in the framework of a network of European collaborations involving leading laboratories. With this purpose, the candidate will develop and apply a methodology of analysis based on electron beam related techniques in order to study these structures and interfaces at the atomic scale. Among others, aberration-corrected scanning transmission electron microscopy and three dimensional characterization techniques will allow the structure; composition and homogeneity of the barrier layers to be investigated while still remain sandwiched. A promising new technique that will be applied to this system will be scanning confocal electron microscopy (SCEM), which in theory is ideally suited to analytical work on systems with extended planar geometries. Indeed, the researcher in charge at the University of Oxford, is a world reference of leadership in the use of high resolution scanning transmission electron microscopy and in the development of SCEM. This stay abroad will provide the candidate a maturity and an expertise level in this scientific field, essential to develop an independent research career.",Nanoengineering of self-forming diffusion barriers for interconnect technologies,FP7,04 June 2014,05 January 2010,173240.8 NANOS3,Eotvos Lorand University * Eötvös Loránd Tudományegyetem,health,"The proposed ITN (NanoS3) have assembled eight academic groups with complementary expertise in synthesis, modeling and characterization. They are joined by two full industrial partners active in the development of novel luminescent materials (LuminoChem), and in the home and personal care sectors (Procter and Gamble). Two associated partners will contribute to the work of our proposed network: BioTalentum is an SME in the field of stem-cell research and the Institute for Surface Chemistry (YKI) is a world-leading research institute in applied surface chemistry. Our work will focus on three priority areas of research: • 1: Organizing Soft Nanoparticles • 2: Dynamics of Soft Nanoparticles • 3: Soft Nanoparticles at Interfaces These S&T objectives are combined with the ambitious objectives to train and promote qualified research project managers in the field of soft matter nanoscience, capable to work in research or industry together with experts in different disciplines and in different countries. We will accomplish our goal by training early stage researchers in a wide variety of modern bulk and surface techniques, as well as in modelling and synthetic methods. We will organize a series of tutorial courses on specialized topics, organize network workshops, and implement secondments and visits. To develop the complementary skills needed to start a successful career either in academia or in R&D we will organize trainings in e.g. Project management, Proposal writing, Presentation skills, IP and patent rights and Innovation.","Soft, Small, and Smart: Design, Assembly, and Dynamics of Novel Nanoparticles for Novel Industrial Applications",FP7,31 March 2016,01 April 2012,3619626.0 NANOSAFE2,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),environment,"Today nanotechnology lets foresee many opportunities for new materials with significantly improved properties as well as revolutionary applications in large industrial fields. However nano-industry stakeholders are currently encountering great problems with hazard control in their plants. Because of their size, nanoparticles released in air cannot only lead to violent explosion but can also impact on the worker health. The NANOSAFE2 project will hence develop and validate at industrial scale a complete hazard management strategy, including: - innovative detection, traceability and characterization techniques for engineered nanoparticles covering the whole chain of some reference particles including production, conditioning, storage, transportation, transformation into final product, during product life and at the end of product life (disposal). - a framework for obtaining conclusive toxicity data of generic interest of the reference particles and the development of new and cheaper rapid screening methods using in vitro techniques and in silico (computer simulation) models - advanced technologies to limit both exposition to nanoparticles and leaks to environment by designing safe production equipment, handling automation, dynamic confinement, individual protection devices, filtration, etc. - evaluate both societal and environmental impacts and contribute indirectly to new legislation and standardization measures relevant for nanoparticles, by involving regulatory bodies (members of CEN). In order to achieve such ambitious goals, the NANOSAFE2 project will gather for a 4-years duration, 5 European industry leaders and 3 innovative SMEs which will share their expertise in production and integration of nanoparticles, supported by 13 research centres of excellence and EU-leader universities and 2 CEN members. 6 EU countries and 1 new member state (Slovenia) are represented within the consortium. NANOSAFE2 covers the whole 'value-chain' of stakeholders.",Safe production and use of nanomaterials,FP6,31 March 2009,01 April 2005,6999837.0 NANOSAFEPACK,Tecni-Plasper SL,environment,"The main aim of the NanoSafePACK project is to develop a best practices guide to allow the safe handling and use of nanomaterials in packaging industries, considering integrated strategies to control the exposure to nanoparticles (NP) in industrial settings, and provide the SMEs with scientific data to minimize and control the NP release and migration from the polymer nanocomposites placed on the market.",Development of a best practices guide for the safe handling and use of nanoparticles in packaging industries,FP7,11 June 2016,12 January 2011,0.0 NANOSCALE,Advanced International School of Advanced Studies * Scuola Internazionale Superiore di Studi Avanzati,health,"The study of biological processes occurring at the nanoscale is becoming a new discipline at the border between Physics and Biology with major scientific challenges and new technological applications. In fact, interactions at the nanoscale between cells/neurons and surfaces with specific nanopatterns appear to control several major biological processes, such as cell proliferation and differentiation. The aim of the present NanoScale proposal is therefore to explore interactions between stem cells, neurons, neuronal networks and surfaces with specific geometrical nanopatterns and nanoprints of specific proteins and molecules. In order to do so, we have formed an interdisciplinary consortium consisting of five major European research centres (SISSA, TASC-INFM, DTU, NMI and ENS) with two SMEs (MCS, Promoscience) gathering biological knowledge and expertise in the fabrication of nanostructures and of their manipulation. The NanoScale proposal will produce and develop a variety of nanodevices for growing, guiding, manipulating cells, neurons and neuronal cultures. It is composed of two major ingredients: i - the combination of a MicroElectrode Arrays (MEAs) with chemical and topographic micro/nanosubstrates controlling the network growth; ii -the coupling with external measuring and/or manipulating devices such as Electron Microscopes and Optical Tweezers. We expect to provide an answer to new scientific issues and therefore achieving major scientific breakthroughs. In addition, our proposal will produce new knowledge and know-how enabling the development of new marketable products that will be commercialised by MCS.",Understanding interactions between cells and nanopatterned surfaces.,FP7,30 June 2011,01 July 2008,3030405.0 NANOSCIENCESTECH,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"The 'nano' field encompasses scientific investigations and experimental processes relevant to structuresand objects with at least one dimension much smaller than micrometers in size, down to single living cells,molecules, and atoms. It reveals a major interdisciplinary trend that clearly ranges from far upstream in physics,computation and biology, where the manipulation of single entities or of small collections of atoms is oftenreferred to as nanosciences, to industry, where the continuing trend towards miniaturization is bringing downprocesses developed for microelectronics to the nanoscale, a domain referred to as nanotechnology. Nowadays,nanoscience technology is hardly taught in academic courses at universities and text books on the subject are stillrare. A knowledge transfer from scientists currently engaged in the field towards younger ones is thus essential.The forum 'NanoSciencesTech' is a coherent series of four schools and one conference in the field ofnanosciences and nanotechnologies. The domains have been selected among those strongly impacted by the nanofield: condensed matter, optics and biology. The specific hot topics addressed by 'NanoSciencesTech' areNanophotonics, Self-organized Nanostructures, Nanomagnetism and Spintronics, Nanotubes, andNanobio-Objects. We expect an attendance of about 400 young researchers from Europe and third countries. Acoherent training will be provided by talented academic and industrial lecturers going from the basics in eachfield to the latest fundamental breakthroughs and most promising applications. In addition, dedicated sessions inthe events will address intersections with the other schools and fields. For example, the bases of nano-instruments for probing nano-objects, nano-fabrication tools or computational nanoscience, will be addressed ina coordinated way by the various events. To our knowledge, the forum 'NanoSciencesTech' is a 'première' atthe European le#",MACRO-EUROPEAN FORUM ON NANOSCIENCES AND NANOTECHNOLOGY : FROM BASIS TO APPLICATIONS,FP6,31 December 2006,01 January 2004,485981.0 NANOSCOPE,London School of Economics and Political Science,health,"I propose to develop and apply a novel approach to optical microscopy to enable the direct visualization and study of dynamics on the nanoscale in biological and condensed matter physics. Given the speed with which nanoscopic objects move at ambient condition, this requires simultaneously very fast (ms) and precise (nm) imaging. The challenge is to avoid excessive perturbation of the system and enable imaging in biologically compatible environments without compromising imaging performance by pushing interferometric scattering to its theoretical limits. Using these advanced capabilities, I will study the dynamics and thereby the structure-function relationships in three fundamental systems that are currently not captured by even the most advanced biophysical approaches. These include: (1) the flexibility of DNA on short length scales, (2) diffusion in artificial and cellular membranes and (3) the three-dimensional power stroke of molecular motors such as myosin and kinesin. Fundamentally, this work aims to develop and establish a high-speed, non-invasive camera on the nanoscale that will enable us to study and eventually understand nanoscopic motion, dynamics and potentials on the relevant, rather than currently achievable, size and time scales.",Optical imaging of nanoscopic dynamics and potentials,FP7,31 December 2018,01 January 2014,1498352.0 NANOSCOPE,IMEP-LAHC Laboratory,photonics,"NanoSCOpe aims at supporting the career development of the candidate by means of a training-through-research project in which the coordination chemistry and physical characterization at the molecular level expertise of the applicant will be combined with the nanotechnology, physical-chemistry, nanophotonics and nanoelectronics expertise of the host institution for handling novel SCO-based switchable molecular materials at the nanoscopic scale as required for their technological application. The main scientific objectives of the research work proposed are: a) the controlled synthesis, nanopatterning and organization on surfaces of novel switchable and photo-switchable materials based on spin crossover complexes, and b) the study of the individual and collective physical properties of the obtained miniaturized systems with the aim of understanding the size reduction and molecular organization effect on the SCO properties during nanopatterning by correlating the miniaturized materials properties with the macroscopic counterparts. NanoSCOpe innovates through the development of original methods for the fabrication of nano-structures of coordination complexes with controlled composition, morphology and 3D architecture and through the study of those materials as single nano-objets using cutting-edge nanotechniques. The results of this multidisciplinary proposal addressing Material Science, Chemistry, Physics and Nanotechnology issues will be crucial for discovering novel nanomaterials with new properties for future technological use. From the technological point of view, NanoSCOpe will demonstrate the feasibility of practical applications in the areas of molecular information storage and molecular sensors by integrating the obtained nano-objects into nanophotonic and nanoelectronic devices. This will definitely contribute broadening the background and competencies of the candidate in Nanotechnology, as an ultimate step for his consolidation as independent researcher.",Mastering novel switchable molecular materials at the nanometric scale for their technological application in the areas of nanoelectronics and nanophotonics,FP7,31 August 2015,01 September 2013,269743.0 NANOSCOPY,University of Tromsoe * Universitetet i Tromsø,health,"Optical nanoscopy has given a glimpse of the impact it may have on medical care in the future. Slow imaging speed and the complexity of the current nanoscope limits its use for living cells. The imaging speed is limited by the bulk optics that is used in present nanoscopy. In this project, I propose a paradigm-shift in the field of advanced microscopy by developing optical nanoscopy based on a photonic integrated circuit. The project will take advantage of nanotechnology to fabricate an advance waveguide-chip, while fast telecom optical devices will provide switching of light to the chip, enhancing the speed of imaging. This unconventional route will change the field of optical microscopy, as a simple chip-based system can be added to a normal microscope. In this project, I will build a waveguide-based structured-illumination microscope (W-SIM) to acquire fast images (25 Hz or better) from a living cell with an optical resolution of 50-100 nm. I will use W-SIM to discover the dynamics (opening and closing) of fenestrations (100 nm) present in the membrane of a living liver sinusoidal scavenger endothelial cell. It is believed among the Hepatology community that these fenestrations open and close dynamically, however there is no scientific evidence to support this hypothesis because of the lack of suitable tools. The successful imaging of fenestration kinetics in a live cell during this project will provide new fundamental knowledge and benefit human health with improved diagnoses and drug discovery for liver. Chip-based nanoscopy is a new research field, inherently making this a high-risk project, but the possible gains are also high. The W-SIM will be the first of its kind, which may open a new era of simple, integrated nanoscopy. The proposed multiple-disciplinary project requires a near-unique expertise in the field of laser physics, integrated optics, advanced microscopy and cell-biology that I have acquired at leading research centers on three continents.",High-speed chip-based nanoscopy to discover real-time sub-cellular dynamics,FP7,31 January 2019,01 February 2014,1490976.0 NANOSCRATCH,AIMPLAS - Plastics Technology Centre * Asociación de Investigación de Materiales Plásticos y Conexas,transport,"The project aims to develop a novel high performance scratch resistant coating technology for plastic pieces at a low cost using an environmental friendly and tailor-made process, over a broad range of plastic materials. These coated plastics can substitute weighty materials, as metallic or glassy components, and high cost engineering plastic materials. The new coating technology to develop is based on self assembly nanotechnology. Nowadays, plastic materials present limited scratch and mar resistance when compared with materials as ceramics, glass or metals. After a short period of use, plastic parts surface is damaged and aesthetically defects appear (blisters, cracks, scratches…). Scratches can be an ideal breeding ground for bacteria, reducing the hygienic properties of plastics materials. These negative properties limit the usability of these materials in a broad range of applications and leading companies are making constant efforts to overcome this problem. NANOSCRATCH approach will provide a novel technology based on the facts that the surface of certain plastics can be modified through a mild oxidation and chemical functionalization process, using self-assembled molecules. This new technique will provide an effective bond between the plastic surface and the nanoparticle coating, due to a highly cross-linked network formed at the surface, avoiding the traditional adhesion problems of coatings applied onto plastics, due to its low polarity, while maintaining the aspect of the original part. The new technique involves three steps: mild oxidation, self-assembly and co-deposition of nanoparticles. Among the main potential applications, the project will focus on high scratch resistance plastic pieces for the automotive industry and white-goods appliances manufacture in order to replace weighty, expensive and non-recyclable Engineering Thermoplastics and glass by PP filled grades, transparent plastics (mainly PC) and ABS",To develop a scratch resistance coating using a molecular self assembly nanotechnology for plastic products,FP7,08 July 2013,09 January 2009,620926.05 NANOSCULPTURE,University College London,manufacturing,"I plan to grow nanometre-sized crystals in confined geometries to examine the strain distributions that result. The crystal growth will employ lithographic processing techniques, made possible by the local expertise in the central clean room facilities of the London Centre for Nanotechnology. My group is world-leading in developing a method called Coherent X-ray Diffraction (CXD). Our CXD strain images of a Pb nanocrystal were published in Nature in 2006. CXD is sensitive to strain because the X-ray diffraction pattern surrounding a Bragg peak can be decomposed into symmetric and antisymmetric parts. To a good approximation, the symmetric part can be considered to come from the real part of the electron density, while the antisymmetric part is a projection of the strain field. The phasing of the data is a critical step that uses a computer algorithm, developed by us, which acts like the lens of a 3D X-ray microscope. CXD works best for nanocrystal sizes between 40nm and 5µm, for crystals strongly attached to substrates and for isolated, fiducialised arrays of crystals that can be cross-referenced with other techniques. To create nanocrystals in this size range, we will use both a bottom-up self-assembly of materials deposited onto templated substrates, designed to introduce strain, and a top-down nanosculpture approach will use lithography techniques to create strain patterns in crystalline materials associated with shapes that are carved into them. The interpretation of the images is the main intellectual output of the project. This will be compared with finite element analysis, and the deviations interpreted as unique properties attributable to the nanoscale. All project participants will work in a design, creation, analysis, interpretation, update cycle that will reveal the new basic principles of nanocrystal structure. In the long run we will transfer CXD technology to Europe: beamline I-13 at Diamond will be ready for CXD in 2011.",Exploration of strains in synthetic nanocrystals,FP7,12 July 2015,01 January 2009,2500000.0 NANOSELECT,Lulea University of Technology * Luleå Tekniska Universitet,environment,"NanoSelect aims to design, develop and optimize novel bio-based foams/filters/membranes/adsorbent materials with high and specific selectivity using nanocellulose/nanochitin and combinations thereof for decentralized industrial and domestic water treatment. NanoSelect proposes a novel water purification approach combining the physical filtration process and the adsorption process exploring the capability of the nanocellulose and/or nanochitin (with or without functionalization) to selectively adsorb, store and desorb contaminants from industrial water and drinking water while passing through a highly porous or permeable membrane. Stable membranes/ filters that withstand the flux, pressure etc during the purification process with out compromising on the perm selectivity will be developed by methodologies including control of pore size, orientation of pores, layered multiple functionality, ALD treatment of the porous surface etc. Functional external stimuli sensitive filter surfaces for reduced bio fouling and enhanced filter cleaning or intelligent design of membrane modules allowing self cleaning will be attempted for antifouling and to increase the service-life of the membranes.NanoSelect focuses on the design, development and testing of membrane based prototypes in collaboration with industry with specific focus on the removal of toxic chemicals, heavy metal ions, pesticides, fertilizers etc from contaminated industrial water and portable modules with high selectivity towards bacteria for drinking water. In addition, the membranes will be evaluated for disposal by composting and its impact on environment, at the end-of-life.These biobased functional membranes provides a highly energy efficient but cheaper, biodegradable, non-toxic and green substrate for water treatment. The successful completion of NanoSelect will have far-reaching impact in decentralised water treatment technolog in developing, transitional as well as the industralised countries",Functional membranes/ filters with anti/low-fouling surfaces for water purification through selective adsorption on biobased nanocrystals and fibrils,FP7,01 July 2018,02 January 2012,3820899.0 NANOSENS,Rovira i Virgili University * Universitat Rovira i Virgili,health,"Affinity biosensors, due to their selectivity, sensitivity and the fact they can be developed in a reagent-less and reusable format, find large application in environmental and clinical analysis. Key elements in biosensor development are: (i) the electrode surface (transducer) chemistry/properties, (ii) the recognition element and (iii) the signal generation element. In this proposal electrodeposition of nano-particles will be investigated as a way of modifying the transducer (electrode) chemistry/properties in order to improve/optimise the performances/layout of electrochemical molecular beacon biosensor. Several applications of RnEs will be investigated. · RnEs as a possible route to improve biosensors sensitivity (due the intrinsic catalytic properties of the nano-particles) · RnEs as a way generating specific attachment sites suitable for the recognition element. · Nano-particles as physical masks (template) for patterning, at nano size level, self assembled monolayer (SAM) of thiolated molecules onto Au surface (definition free sites, suitable for the recognition element attachment, in an antifouling matrix). Furthermore the influences of nature of the redox centre over the performances of electrochemical molecular beacon will be investigated in this proposal. The knowledge generated will be applied to the realisation of electrochemical molecular beacon DNA sensors for the prenatal diagnosis of Cystic Fibrosis and Thalassemia two of the most common genetic diseases. These areas of application have been chosen because of the relevance of the two diseases and because of the necessity to simplify the pre natal diagnosis of them that currently is performed with invasive, costly and risky procedures such as amniocentesis and 'chorionic villa sampling'.",Nano-particles: their application in the development of electrochemical molecular beacon biosensors.,FP7,28 February 2010,01 March 2008,151936.0 NANOSENS,National Institute of Research & Development for Technical Physics * Institutul Naţional de Cercetare-Dezvoltare pentru Fizică Tehnică,health,"The overall aim of the NANOSENS project is to upgrade the research and innovation capacity of the National Institute of Research and Development for Technical Physics (NIRDTP) to the highest European level in microsensors for medical applications and biosensors based on magnetic nanoparticles and nanowires. NIRDTP is a very promising European research organisation in the fields of nanoscience and microsystems. The Institute has a total staff of 73 persons (researchers and administrative). NIRDTP's existing scientific expertise and facilities will be further developed through a range of research and innovation capacity building activities derived from NIRDTP's SWOT analysis. The activities will increase NIRDTP's visibility, society/regional responsiveness and innovation potential for the most advanced topics of microsensors and biosensors: Research Topic A: Microsensors for Medical Applications A1. Acoustic microsensors based on nano- and microwires for medical applications; A2. Implantable magnetic microsensors based on nanostructured materials for medical applications; Research Topic B: Biosensors based on Nanoparticles and Barcode Nanowires B1. Sensors based on nanosized detection elements for applications in nanomedicine; B2. Biosensors based on multilayered nanowires for the detection of biomolecules. Central to the activities are twinning partnerships with six specialist research organisations: 1. Sheffield Centre for Advanced Magnetic Materials and Devices within the Department of Engineering Materials, University of Sheffield, UK (SCAMMD); 2. Department of Materials for Information Technologies in the Instituto de Ciencia de Materiales de Madrid, Spain (ICMM-CSIC); 3. Siemens Corporate Technology, Erlangen, Germany (SIEMENS); 4. Nanobioelectronics & Biosensors Group in the Institut Català de Nanotecnologia, Barcelona, Spain (ICN); 5. Solid State Physics group within the Department of Physics and Astronomy, University of Glasgow, UK (UGLA); 6. Materials Science Electron Microscopy Department at the University of Ulm, Germany (UULM). NIRDTP will increase its human potential by hiring seven experienced researchers, one IP manager and one Innovation Manager, as well as organising know-how exchanges and trainings for existing and new staff with twinning partners. NIRDTP will increase its technology potential by purchasing a scanning Auger nanoprobe equipment, upgrading its RF sputtering equipment with laser ablation capabilities, and purchasing a gel electrophoresis system. Finally, to ensure its research quality and innovation capability, NIRDTP will be ex-post evaluated by a team of international, independent experts nominated by the Commission.",Upgrading the capacity of NIRDTP to develop sensing applications for biomedicine using magnetic nanomaterials and nanostructured materials,FP7,30 November 2016,01 June 2013,2422076.0 NANOSENSE,Academisch Ziekenhuis Groningen * University Medical Center Groningen,health,"Background: Traditionally, immunoassays have been separation based, meaning that the analyte of interest goes through several steps of antibody binding, washing and separation before final detection. This type of assay requires high use of consumables, which is expensive, and is time consuming due to all the steps. While, in a non-separation assay no separation steps are involved and the use of consumables is limited, making the assay less expensive and with a much shorter assay time. A non-separation assay will typically be run on a clinical chemistry platform intended for high-throughput of analytes, making homogeneous non-separation immunoassays a high potential market growth opportunity. Rationale: There is a need for high sensitivity non-separation immunoassay technology for general clinical chemistry instrument platforms, in particular for large protein disease markers of low concentration such as NT-proBNP and PSA, and a long list of other plasma proteins, protein hormones and specific antibodies. Such new technology will significantly change the diagnostic industry and health care providers towards greater efficacy. The goal of this project is to move immunoassays from slow and expensive methods to fast, high-throughput super-sensitive nanoparticle based methods, demonstrate it's working within the specifications, and generate intellectual property for such technology. Methods: To achieve the goal of this project, methods and techniques will be taken into use to optimise each component in the assay. Perspectives: When such technology was developed for small molecule markers 15 years ago, a big change in the diagnostic industry was seen, and two small SMEs grew into big industrial corporations. We foresee that similar effects will be seen when such technology is developed for large molecule markers.'",Moving sensitive immunoassays from slow and expensive to fast and affordable nanoparticle-based methods,FP6,31 December 2009,01 January 2007,1433600.0 NANOSENSOMACH,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"Chemically modified metallic nanoparticles (NPs) or semiconductor quantum dots (QDs) are central components for the future development of nanotechnology and nanobiotechnology. This program aims to introduce new dimensions into the field of nanotechnology and nanobiotechnology by synthesizing, characterizing and assembling molecule- or biomolecule-modified nanoparticles (NPs)/Quantum dots (QDs) hybrid nanostructures that perform tailored and programmable functionalities. The project will include two complementary research activities. One direction will include the generation of electropolymerized ligand-functionalized Au NPs matrices on electrode surfaces. By tethering of appropriate ligands to the NPs, imprinted matrices for selective sensing, and signal-triggered NPs 'sponges' for the selective uptake and release of substrates will be designed. Also, electrochemically induced pH changes by the NPs matrices will be used to control chemical reactivity (e.g., sol-gel transitions, activation of the ATP synthase machinery). The second research direction will implement ligand-modified QDs for the sensing of ions or molecular substrates. Similarly, nucleic acid-functionalized QDs will be used to develop new versatile sensing platforms exhibiting multiplexed analysis capabilities. One platform will include the quenching of the QDs by G-quadruplexes, whereas the second platform will use biochemiluminescence resonance energy transfer (BRET) as readout signal. Also, QDs-modified supramolecular DNA nanostructures will be designed to perform programmed machinery functions such as 'bi-pedal walker', 'seesaw', 'gear' or 'tweezers', and the machinery functions will be transduced by the optical properties of the QDs. Finally, DNA-machines that trigger the isothermal amplified replication of the analyzed nucleic acid will be designed, and QDs tethered to the machine will optically transduce the replication process at real-time.",Nanoengineered Nanoparticles and Quantum Dots for Sensor and Machinery Applications,FP7,31 December 2015,01 January 2011,2167400.0 NANOSH,Finnish Institute of Occupational Health * Työterveyslaitos,health,"Nanotechnology is a rapidly increasing area of industry providing new and innovative solutions into many industrial sectors. The challenge faced by policy makers and the scientific community is that very little is actually known about the health effects of nanoparticles. It is essential that reliable information should be gathered before these particles enter widespread use to avoid potential health problems induced by the exposure to workers and consumers. The overall goal of this research project is to characterize features of specific engineered nanoparticles, to the delineate levels of exposure in occupational environments, and to explore health effects of exposure to these particles. Exposure levels will be evaluated under laboratory conditions and in occupational environments. The particles will be characterized with respect to their size distribution, solubility, surface activity, and potential for agglomerate formation. Health effects to be studied include genotoxicity and inflammatory responses. Genotoxicity will be assessed in relevant pulmonary cells measuring DNA and chromosomal damage. Inflammatory responses will be evaluated by measuring alterations in the panorama of pulmonary inflammatory cells as well as expression of biochemical markers of inflammation, i.e. cytokines and chemokines in vivo. To assess the effects on the vasculature, the potential of nanoparticles to induce proinflammatory or prothrombotic effects in the microcirculation of experimental animals will be explored. Assuring the safety of new nanomaterials will be a crucial prerequisite for successful promotion of nanotechnological innovations and their applications in the future. This research aims at creating a reliable and sound foundation for the assessment of safety of nanoparticles, and in this way to the project will have a significant impact on the European capability for conducting research and innovation in the area of nanotechnology.",Inflammatory and genotoxic effects of engineered nanomaterials,FP6,31 October 2009,01 November 2006,2399234.0 NANOSICON,German Aerospace Center * Deutsches Zentrum für Luft-und Raumfahrt,energy,"Deficiency of natural energy resources on Earth makes advanced energy management a challenge. Efforts are taken to harness cheap, inexhaustible, eco-friendly renewable sources of energy. Among these, thermoelectric (TE) conversion is a promising principle. Best materials for TE application are non-conventional heavily doped semiconductors. In particular, high temperature stable silicides (higher manganese silicides = HMS, CrSi2 and others) represent suitable candidates for demanded TE applications operable at high temperature. A main aim of TE materials development is to improve the figure of merit ZT, which essentially depends on the energy band structure and scattering of carriers and phonons in the material. It is planned to investigate qualitatively the transport behaviour of HMS compacted from nano-sized powders, to optimize its properties by chemical synthesis, and to reach a reduction of the thermal conductivity in nano-crystalline material. Starting from the synthesis of nano-powders by melting and ball milling, forming of a nano-structure with suitable scaling will be optimized by a rapid hot pressing technology. CrSi2 and other high temperature silicides will be optimized in a similar way for high electrical and thermal conductivity. They shall be applied as contacting materials and interlayers, ending up to advanced materials and technology procedures for high temperature thermogenerators. Materials will be characterized by XRD, SEAD (structure), TEM, SEM (morphology), EDAX (analysis). Having achieved the targeted nano-structure, the TE properties will be measured in dependence on temperature for optimising the application-relevant material parameters. The performance of thermogenerator devices based on the new solutions will be tested by unique measuring techniques of the host. The fellow will deepen his knowledge and experience on TE materials and thermogenerator technology for high temperature and is expected to develop superior contacting methods.",High-temperature stable nano-structured silicides for highly efficient thermogenerators and their contacting technology,FP7,31 July 2010,01 August 2008,159828.0 NANOSIL,INPG Entreprise SA,information and communications technology,NANOSIL Network of Excellence aims to integrate at the European level the excellent European research laboratories and capabilities in order to strengthen scientific and technological excellence in the field of nanoelectronic materials and devices for terascale integrated circuits (ICs) and disseminate the results in a wide scientific and industrial community.,Silicon-based nanostructures and nanodevices for long term nanoelectronics applications,FP7,03 July 2013,01 January 2008,0.0 NANOSINTHER,German Aerospace Center * Deutsches Zentrum für Luft-und Raumfahrt,energy,"Thermoelectric materials are attracting huge attention due to their peculiar functional properties allowing for direct conversion of heat into electricity, solid state cooling, and sensing of thermal quantities. Nowadays, thermoelectric material performance and technology is under dynamic development aimed at improved device applications for energy converters, Peltier coolers and thermoelectric sensors. The proposal target is the development of compaction technology and optimization of sintering conditions to fabricate nano-structured thermoelectric materials with improved performance. The experimental work will focus on Skutterudites based on CoSb3 and Bi2Te3 materials. Further highly effective thermoelectric materials like Zn4Sb3 and Clathrates will be involved. To bridge the gap between preparation of nano-precipitates and testing of thermoelectric performance, advanced compaction techniques are required to conserve the beneficial effects of the nano-structure but reaching high mechanical strength. This topic currently appears as a bottle neck to implement theoretically predicted improvement of nano-structures to thermoelectric devices and up-scaled technologies which are promising a breakthrough in thermoelectric technology with wide-spread product applications. Methods applied include synthesis of nano-particles by chemical alloying, forming of compacts by cold pressing, sintering of nano-structured components by hot pressing with rapid heating rate, and subsequent characterization. Modeling work on densification and grain growth of nano-particles will provide theoretical understanding and guidelines to obtain high performance nano-structured thermoelectric materials. The fellow will deepen his knowledge and experience on compaction of nano-powders and is expected to develop superior optimized compaction technologies. He will work as an integrated part of a dynamic excellent team of international composition.",Sintering Technology for Nano-structured Thermoelectrics,FP6,30 April 2007,01 May 2005,159332.0 NANOSIRNA,IRCCS - Istituto Nazionale dei Tumori,health,"The scientific objective of the research carried out in this International Research Staff Exchange Scheme, is the development of a new technology to effectively deliver siRNA to cancer cells by the embedding of a polyplex into the multilayers and multifunctional nanocapsules. We propose to target pro-survival and anti-apoptotic factors in human cancer cells by using siRNA encapsulated into polyelectrolytes nanocapsules.When siRNAs are formulated into degradable polymer nanocapsules they may be protected from nuclease digestion and last longer than naked siRNAs improving their efficacy and therapeutical properties. These capsules will be prepared by the LbL deposition of interacting polymers onto a sacrificial porous colloidal template followed by core removal. Nanoengineered micro-nanocapsules composed of sequentially assembled polymer layers hold immense promise for a variety of biomedical applications. Furthermore the optimization of intracellular pathway of nanostructures may likely be a key for the development of effective nanoparticles based targeted therapeutics. As the challenge of siRNA delivery by nanocapsules is met, it will be possible to advance RNAi therapeutics rapidly into clinical studies for many diseases, including some which remain untreatable or poorly treated by conventional drugs.",Transfection Ability and Intracellular Pathway of LbL Nanostructured siRNA Delivery Systems.,FP7,01 January 2014,02 January 2011,48600.0 NANOSMART,Universiteit Utrecht * Utrecht University,health,"Advances in the preparation of nanotechnology-based materials in medical science pose new challenges in the design of smart nanodevices capable of meeting clinical needs. These systems are called to solve the issues associated to a non-specific delivery of drugs, which lead to the failure of a large number of treatments for oncological diseases. A selective and safe carrier for drug delivery should be actively targeted to malignant cells and display a stimulus-responsive behavior controlled by external means. The present project is aimed at developing targeted delivery vehicles able to release the required dose of chemotherapeutics in response to local temperature increases. For this purpose, an emerging technology based on magnetic resonance imaging (MRI) and high intensity focused ultrasounds (HIFU), MRI-guided HIFU, will be combined with selective nanomedicine to provide a full spatial and temporal control of the release process. This novel MRI-assisted triggered drug delivery allows improving the performance of chemotherapy and better monitoring the regression of disease. The research project is built around two main objectives: 1) the design and synthesis of novel biocompatible thermosensitive carriers based on inorganic-organic hybrid nanospheres with targeting nanobody moieties, and 2) the in vitro and in vivo evaluation of MRI-guided HIFU-triggered drug release. This proposal represents a unique opportunity in the context of nanotheragnostics for tailored chemotherapy, and means a significant step towards its clinical translation. The project is in the core of 2 of the 10 themes of the FP7 Cooperation Program, Health and Nanosciences, Nanotechnologies, Materials & New Production Technologies. This research in smart drug delivery nanodevices constitutes a highly multidisciplinary approach with large impact in near future advanced therapies and with a great chance for collaboration and networking between European groups and industrial partners.",Smart nanosystems for advanced cancer therapy,FP7,28 February 2014,01 March 2012,191675.0 NANOSMART,University of Salamanca * Universidad de Salamanca,health,"As a result of the research undertook in the MYCAP ERC project, Dr MartÃn del Valle's team have developed a new smart nanoparticle for delivering cisplatin, which is the current lung cancer standard of care (SoC). In order to accelerate its market entry, the present 'Proof of Concept' (PoC) project, named NANOSPART, will conduct in vitro validation of cisplatin nanoparticles through cell lines culture assays, as well as the technological optimization of the drug delivering system and the upper spray-based technology arisen from 'MYCAP' ERC funded. The work undertaken so far requires further investment in applied research, in order to turn the outputs shown above into a commercial proposition. The NANOSMART project will make an important contribution towards the future pre-clinical and clinical phases, and new key industrial applications. Dr. MartÃn del Valle´s team have developed a new drug delivery system (DDS) for lung cancer treatment based on polymer nanoparticles, as a result of MYCAP project. Dr MartÃn del Valle now aims to progress this idea to PoC through the NANOSMART project, which has mainly three goals: defining the right chemical properties of these nanoparticles; determining the optimal dose of cisplatin-conjugates in relation to toxicity and efficacy parameters; In terms of expected outcomes, the project will contribute to meet critical market needs in lung cancer treatment. Globally, lung cancer is one of the most common types of cancer, with an estimated 1.2 million new cases being diagnosed every year. Despite the emergence of new treatments, 85% of lung cancer patients don't survive, which is mainly due to metastatic disease . Because of the overall poor prognosis, new treatment strategies for lung cancer patients are urgently needed. Dr. Eva MartÃn del Valle and her team from University of Salamanca, are willing to address this issue with a new approach that utilises novel nanopartictechnology to deliver the current SoC (cisplatin).",Smart nanoparticle system for lung cancer application,FP7,31 March 2014,01 April 2013,143400.0 NANOSMARTS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"This project integrates the development of (a) bioconjugated silicon nanoparticles (NPs) as new, < 3nm, fluorescent probes and (b) dual-emission band fluorescent biosensors for protein conformation investigations to be applied in diagnostic procedures related to tumor biology and neurodegenerative diseases. Epidermal growth factor receptor (EGFR) is an important therapeutic target in a variety of tumors, particularly malignant gliomas where mutation and/or amplification of EGFR is often observed. The laboratory has demonstrated in a pilot study the specific binding of biomolecules conjugated to Quantum Dots to patient-derived glioma spheroids. High wavelength emitting QDs are necessary to distinguish binding from tissue autofluorescence but such QDs are large (~40 nm) and do not penetrate deeply into tissues or access cellular junctions. The project will develop smaller, more inert, and less toxic conjugated silicon nanoparticles that can ultimately be used for the detection of residual glioma cells in patients after surgical resection. Additionally, more complex composite nanoparticles that selectively internalize in the tumor cells will be investigated as vehicles for drug delivery or selective killing. The aggregation of proteins and peptides is a fundamental feature of neurodegenerative diseases such as Alzheimer's, Parkinson's and spongiform encephalopathies. It is not clear whether the fibrillar aggregates or smaller forms of the implicated proteins are the cause of cytotoxicity. Both in vitro assays and in vivo studies are hampered by the lack of probes that can distinguish and quantitate early stages of the aggregation phenomenon. This project will develop fluorescent biosensors for protein folding on the basis of environment sensitive ratiometric dyes that exhibit dual emission. Such dyes are prospective tools for a development of facile and rapid assays for protein folding for application in diagnostics and drug screening assays.",Smart nondimensional biosensors for detection of tumor cells and cytotoxic amyloids intermediates.,FP7,31 August 2010,01 September 2008,156993.0 NANOSOL,University of Castilla-La Mancha * Universidad de Castilla-La Mancha,health,"In this project (NANOSOL), we wish to study the femtosecond to millisecond dynamics of some selected triphenylamine dyes in solutions and confined within MCM-41 mesoporous silica material in absence and in presence of TiO2. The dyes are being proposed as potential candidates for solar energy conversion with an efficiency in classical configuration up to 5.33%. We will interrogate their relaxation dynamics and study the effect of zeolites nanoconfinement on the related and subsequent elementary events from fs to ms regime. Powerful techniques based on ultrafast-laser and single-molecule technologies will be our tools to follow the electronic flow from its birth triggered by a photonic excitation of the dye to its death due a charge recombination. We will then explore for the selected dyes the relationship between the time domain and nature of the zeolites (space domain, nano to micrometer domain).This relationship will be examined at a single molecule and particle level with both time and spectral resolutions. The results will be correlated to their solar-energy conversion efficiency in a classical scheme, and will serve for designing confined systems for a new generation of photovoltaics cells. We believe that the expected results will be of great interest to the scientific community working in nanotechnology (nanoLED's, nanostwitches, etc) nanomedicine (drug delivery), and environmental science (clean energy), and in particular to those performing dye-sensitized solar cells.",From Femto- to Millisecond and From Ensemble to Single Molecule Photobehavior of Some Nanoconfined Organic Dyes for Solar Cells Improvement,FP7,31 May 2011,01 June 2009,161899.0 NANOSOUND,Bar-Ilan University,energy,"Nanotechnology is expected to become a driver of sustainable energy development and energy storage. The possible photovoltaic (PV), thermoelectric, electrochemical application of various nanostructures including carbon nanotubes, C60, semi-conductor quantum dots has been intensively investigated. In the latter case, CdSe, CdTe and PbS nanocrystals have been successfully integrated in PV cells whereas transition metal oxides and phosphates nanocrystals have proven to be more efficient than their bulk counterparts as electrode materials for Li-ion batteries. This breakthrough has been made possible by the use of solution phase routes to tailor the size, shape, surface state and self-assembly of the nanoparticles We propose to explore the sonoelectrochemical and plasma assisted deposition methods to directly coat selected substrates by silicon nanocrystals. Glass and stainless steel substrates will respectively be used to measure the optical properties (absorption coefficient and photoluminescence) of the films and to test the electrochemical performance as an anode for Li-ion battery. This method will then be extended to polymers and fibers.",Wet deposition of silicon for electrochemical devices,FP7,31 March 2012,01 April 2010,241886.0 NANOSOURCE,National Technical University of Athens,photonics,"The proposal aims at mutual technology transfer between two academic research laboratories and an industrial partner. NTUA has experience on sensors and electronic/optoelectronic devices based on nanoparticles arrays, NCSRD has experience on the nanoscale characterization of materials and microelectronic device fabrication technologies and MANTIS Deposition Ltd has developed a nanoparticle source able to synthesize nanoparticles of extreme size uniformity. A main scientific goal of the project is the formation of 2-dimentional and 1-D configurations of nanoparticles with controlled size and density. The accomplishment of this target will enable the fabrication of nanoparticle based sensors and electronic/optoelectronic devices beyond the state-of-the-art. The academic partners will have the opportunity to advance their research in the above fields by acquiring knowledge in the nanoparticle manufacturing technique of Mantis. From this exchange of knowledge the SME will benefit from the investigation of its product applicability in these new fields. The complementarity of know-how of the partners which extends from the nanoparticles to electronic sensors and devices fabrication technologies supported by the characterization of electronic, optical and structural properties of materials used it is a solid background for the partners to further develop their research agenda through mutual transfer of technology.",METALLIC AND SEMICONDUCTING NANOPARTICLE SOURCE FOR ELECTRONIC AND OPTOELECTRONIC APPLICATIONS,FP7,31 July 2012,01 August 2008,1132425.0 NANOSPAD,Polytechnic University of Milan * Politecnico di Milano,health,"NANOSPAD aims to develop a highly sensitive system for rapid analysis of protein microarrays, with compact size and features suitable for use by general practitioners. It will represent a demonstration of a methodology suitable in general to the rapidly growing field of proteomics and will be validated in allergy diagnostics (serum allergen-specific IgE). NANOSPAD is focused on miniaturization as an effective way of achieving improved performance for analytical methods. It will therefore pursue new developments in diversified technologies: optoelectronics, microelectronics, microfluidics, surface chemistry, chemiluminescence and electrochemiluminescence. A new monolithic matrix detector of Single-Photon Avalanche Diodes (SPAD) will be developed in silicon microelectronic technology, with each element capable of detecting single optical photons with high quantum efficiency and low noise and number of elements matched to the number of spots in a microarray. This detector will be the base for the design and fabrication of a prototype of compact analytical apparatus, where the detector elements must be conjugated to the spots of the microarray and various electronic, optical, mechanical and microfluidic subsystems must efficiently interact. New coating techniques will be established for the surface of the microarray substrates (glass, silicon, ITO) with polymers for specific bonding of target proteins. Chemiluminescent and electro-luminescent labels will be developed, aiming to enable highly sensitive measurement of serum IgE and avoid problems associated with laser excitation of fluorescent probes. Dedicated software will be developed for making possible easy and efficient operation of the apparatus by general practitioners and for a better understanding, evaluation and dissemination of the data obtained by exploiting ICT facilities. NANOSPAD will create and maintain a website, will carry out a market study and will elaborate an exploitation plan.",Protein microarray for enhanced diagnostics at low cost by integration of new technological developments,FP6,31 May 2009,30 November 2005,2500000.0 NANOSPARK,TECNA SRL,energy,"Carbon nanotubes have many unique and extreme physical properties for this reason they will playa key role in the next future of society. Many governments allover the world are investing great resources in nanotechnologies research activities. The reason is the great performances of nanostructured materials and the large variety of applications of these technologies. The objective of this proposal is to realize a new machinery based on a cheap technological procedure, the Channel Spark Ablation (CSA), to produce high quality single walled carbon nanotubes which should yield the same quality as laser ablation, but at much lower costs. The nanotubes produced by this equipment will be used as passive electronic elements into innovative solar cells and dye sensitised solar cells. The major innovation of the proposal IS the idea to adopt an innovative technology to provide single-walled nanotubes at first on the kilogram scale and ultimately on a tonne scale. The.CSA is a system based on the pulsed electron-beam generation from the glow-discharge plasma environment. The applicability of the CSA to nanotubes preparation relies on the high effective temperatures that can be reached at the target surface and on its similarities to Pulsed Laser Ablation. It is clear that the development of sophisticated equipment and its further adjustment required for different materials utilisation can not be tackled by an only company. The contribution of the RTD performers will be essential to avail the indispensable know-how and resources to overcome the theoretical and technical problems and so to get the final positive result. The economical reason of the trans-national cooperation is given by the great industrial interest, allover the Europe, for this new, promising technique for nanotubes mass production. Actually the most important limitation of the nanostructured materials is due to the high production cost mainly due to high energy consumption and low process pro",Development of a new machinery for nanotubes mass production based on the channel Spark Ablation technique (NANOSPARK),FP6,31 January 2007,01 November 2004,860992.0 NANOSPEC,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,energy,"To continue the path of cost reduction in photovoltaics the efficiency of silicon solar cells must be increased. With higher efficiencies more kWh can be produced from the same amount of silicon, which is the dominating cost factor at present. Fundamental loss mechanisms limit the maximum achievable efficiency: around 20% of the incident power is lost, because photons with energies below the band-gap are transmitted. Upconversion of two low energy photons into one usable photon reduces these losses. In this project we will realize upconversion with the help of nanostructures and nanotechnoloy-based materials and show a significant improvement in solar cell efficiency. The combination of upconverting Er-based phosphors with PbSe/PbS core shell quantum dots increases the spectral range of light that is upconverted. The quantum dots will be incorporated into a fluorescent concentrator to achieve concentration within the upconverting device. Both the increased photon flux due to a wider spectral collection and the additional geometric concentration will increase upconversion efficiency because of its nonlinear characteristic. Optical nanostructures shall serve as selectively reflective structures that avoid unwanted parasitic absorption. The development of very efficient quantum dots and suitable host materials, the optimization of the upconverter and the fabrication of photonic structures are main objectives. Additionally, solar cells and system designs will be optimized, to make the best use of upconverted photons. A thorough understanding of the underlying principles is critical for the success, so gaining knowledge about nanostructures and materials is a major goal. The big advantage of this concept is that the solar cells remain fairly unchanged. The proposed concept opens a technology path for an evolutionary development of silicon solar cell technology to efficiencies towards 30%, starting from the solid base of today's established silicon technology.",Nanomaterials for harvesting sub-band-gap photons via upconversion to increase solar cell efficiencies,FP7,31 May 2013,01 June 2010,3033843.0 NANOSPEC,IMEP-LAHC Laboratory,information and communications technology,We plan to develop and make use of novel out-of-equilibrium spectroscopy techniques that give access to energy transfers in,Novel Out-of-Equilibrium Spectroscopy Techniques to Explore and Control Quantum Phenomena in Nanocircuits,FP7,11 June 2017,12 January 2010,0.0 NANOSPID2,Technische Universiteit Delft * Delft University of Technology,photonics,"The ultimate limit in the miniaturization of electronics and photonics is at the nanometer scale. Here the signal level can be controlled at the fundamental level of a single electron and a single photon. These limits are actively being pursued for scientific interest with possible applications in the area of quantum information processing and communication. We propose novel devices aimed at single photon detection and single spin memory using nanowires. The basic building block is a III-V quantum dot defined in a Si nanowire. We will develop the following technology: (1) growth of complex semiconductor nanowire, (2) quantum state storage and transfer onto a photon state for the memory device, and (3) single photon detection and electron multiplication for single photon detection. The nanowires will be grown by the vapor-liquid-solid mechanism. The structures and devices obtained after growth and each nanofabrication steps will be thoroughly characterized and the final test devices performances will be evaluated.",Nanowires for single photon detection and spin memory devices,FP7,29 February 2012,01 March 2010,160748.0 NANOSPIN,Julius Maximilians University of Würzburg * Julius-Maximilians-Universität,information and communications technology,"NANOSPIN aims at the development of novel multifunctional spintronic nanoscale devices whose mode of operation is designed to take optimum advantage of the specific magneto electric properties of ferromagnetic semiconductors. The devices combine non-volatility, low current consumption, high switching speed and excellent scalability. The project addresses a number of interlinked novel device concepts for the magnetic writing of information, including current induced switching and current induced domain wall motion, combined with novel readout concepts based on tunneling anisotropic magneto resistance and double barrier structures. In addition the performance of the devices will be investigated in the frequency range beyond 1GHz. Since the project is strongly device oriented, we will use the well established and well understood ferromagnetic semiconductor (Ga,Mn)As as a vehicle material. This will enable us to focus on device action, rather than on materials issues. While this implies that the devices studied will necessarily operate at low temperatures only, the concepts developed by us should directly apply to any p-type ferromagnetic semiconductor. In this manner, the project complements ongoing materials research on room temperature ferromagnetic semiconductors. The work is carried out by leading European groups in the fields of spin transport in semiconductors, nanolithography, ferromagnetic semiconductor growth and characterization. Several industrial and semi-industrial partners will monitor the potential of the developed devices for industrial applicability and commercialisation for post CMOS applications.",Semiconductor Nanospintronics,FP6,31 December 2008,31 December 2005,1740000.0 NANOSPIN,University of Leicester,information and communications technology,"The NANOSPIN project will study complex magnetic nanostructures consisting of a central core with one or more surrounding shells that will be functionalised to self- order on surfaces for applications in classical and quantum ultra-high density information storage. The advanced manufacturing technique we propose uses metal condensation in superfluid He droplets, which is a technology with enormous flexibility. It enables the production of core-shell particles with a free choice of ferromagnetic and antiferromagnetic core and shell materials and an arbitrary number of shells. This degree of control will allow us to engineer the internal spin configuration of an individual nanocluster and to create spin structures that have never been produced before, either naturally or artificially, with a wide range of magnetic properties. The technique will also allow us to coat the nanoparticles with a final shell to promote the ordering of arrays of the designed nanoparticles on surfaces for specific applications. This ability will have an enormous impact on the technological areas of spintronics and magnetic storage. Examples include particles smaller than 5nm that are blocked at room temperature enabling classical data storage densities higher than 10Tb/cm2, and particles embedded in superconducting matrices in states of quantum superposition on which quantum qubits can be stored. Single-particle read/write processes and a new method to erase all data in a nanoparticle assembly using microwaves will be demonstrated. We will also assess the functionalised nanoparticles as qubits in quantum information processing systems. The programme brings together 8 partners from 2 INCO and 6 EU countries. It combines state-of-the-art instrumentation with advances in cluster production technology and will provide the fundamental understanding required to bring highly advanced technologies close to the market.",Self-Organised Complex-Spin Magnetic Nanostructures,FP6,30 April 2008,01 February 2005,1873997.8 NANOSPIN,Free University of Berlin * Freie Universität Berlin,information and communications technology,"The latest concepts for quantum computing and data storage envision the use of single spins, which can be addressed and manipulated reliably. One of the main limitations towards this challenging goal is the ultra-short lifetime of excited spin states due to the interaction with the contacting leads. Another limitation is that coherence between individual spins is quickly lost. Already the measurement process for resolving coherent electron-spin interactions at the single atom level is highly challenging and has not been achieved so far.",Nanoscale spin interactions and dynamics on superconducting surfaces,FP7,04 June 2021,05 January 2014,0.0 NANOSQUID,Weizmann Institute of Science,health,"At the boundaries of physics research it is constantly necessary to introduce new tools and methods to expand the horizons and address fundamental issues. In this proposal, we will develop and then apply radically new tools that will enable groundbreaking progress in the field of vortex matter in superconductors and will be of great importance to condensed matter physics and nanoscience. We propose a new scanning magnetic imaging method based on self-aligned fabrication of Josephson junctions with characteristic sizes of 10 nm and superconducting quantum interference devices (SQUID) with typical diameter of 100 nm on the end of a pulled quartz tip. Such nano-SQUID on a tip will provide high-sensitivity high-bandwidth mapping of static and dynamic magnetic fields on nanometer scale that is significantly beyond the state of the art. We will develop a new washboard frequency dynamic microscopy for imaging of site-dependent vortex velocities over a remarkable range of over six orders of magnitude in velocity that is expected to reveal the most interesting dynamic phenomena in vortex mater that could not be investigated so far. Our study will provide a novel bottom-up comprehension of microscopic vortex dynamics from single vortex up to numerous predicted dynamic phase transitions, including disorder-dependent depinning processes, plastic deformations, channel flow, metastabilities and memory effects, moving smectic, moving Bragg glass, and dynamic melting. We will also develop a hybrid technology that combines a single electron transistor with nano-SQUID which will provide an unprecedented simultaneous nanoscale imaging of magnetic and electric fields. Using these tools we will carry out innovative studies of additional nano-systems and exciting quantum phenomena, including quantum tunneling in molecular magnets, spin injection and magnetic domain wall dynamics, vortex charge, unconventional superconductivity, and coexistence of superconductivity and ferromagnetism.",Scanning Nano-SQUID on a Tip,FP7,30 November 2013,01 December 2008,2000000.0 NANOSTAR,Chalmers University of Technology * Chalmers Tekniska Högskola,photonics,"Objectives: Mastering nanostructured multifunctional ferroelectric films for low cost mass production of microwave devices. The main focus will be concentrated on the development of the theory, fabrication processes and device demonstrators for functional validation of nanostructured multifunctional ferroelectrics films and components. Tuneable Thin Film Bulk Acoustic Resonators (TFBAR), varactors, and delay lines are typical components to be developed. The demonstrators will be developed for microwave communications applications. They are potentially useful for optoelectronics and sensor applications. The objectives are in line with FP6-2004-IST-NMP-2 (IST-NMP-3 Materials, Equipment and Processes for Production of Nano-Photonic and Nano-Electronic Devices), and address the field of intelligent manufacturing systems: nano-electronics science and technologies. Innovations include development of nanostructured ferroelectric films with engineered, radically new properties, exploiting new physical effects in nanostructured ferroelectrics in devices with new functionalities. Reduction of the temperature dependence, hysteresis, losses, noise and parameter drift along with increased long term stability and tuneability will be addressed. The capabilities of the nanostructured ferroelectrics will be demonstrated by functional validation in integrated nano-electronic microwave demonstrators. Tuneable TFBARs are one of the new devices with new functionality, which has no analogues in electronics industry. Main milestones: i) Development of industry relevant fabrication processes for nanostructured ferroelectric films with radically new properties ii) Validation via device demonstrators and circuit applications of the demonstrators iii) Generation of new knowledge in the physics, fabrication technologies. The project combines expertise in theoretical and experimental physics, materials science, manufacturing, device and system engineering",Nano-Structured Ferrolectric Films for Tuneable Acoustic Resonators and Devices,FP6,14 September 2008,14 May 2005,2803351.0 NANOSTEMCELLTRACKING,University of Liverpool,health,"Better understanding on stem cell tracking is required before regenerative medicines therapies (RMTs) can be used. However, there is not a single molecular imaging technology capable of providing the breadth of information required. For instance, while MRI offers excellent spatial resolution, sensitivity is low, whereas for SPECT/PET, the converse is true. In this context, the combination of nanotechnology and new imaging techniques such as photoacoustic imaging (PAI) emerge as potential disruptive technology. Biocompatible nanoprobes can be rationally designed to label specific cell without interfering with biological parameters such as differentiation or metabolic processes but improving the contrast of the imaging technique. Gold nanorods and more complex structures such as hollow nanoparticle or hybrids show special optical properties that enable their use as contrast agents for PAI achieving then enough sensitivity to monitor single cells. Moreover, these optical properties are easily tunable and can be adjusted to perform a multiple real time labelling thanks to the rapid acquisition and the extremely high resolution of PAI. Thus, the combination of these two technologies together will provide a non-invasive, long term, in vivo cell tracking of stem cell in models of kidney injury already developed and validated. Thus, the amelioration of fibrosis and the recovery of renal function amongst other will be assessed together with the safety studies that will include biodistribution, tumourigenesis, inflammation, systemic toxicity, etc. All together will contribute to establish efficacy and safety of RMTs.",Nanoparticle probes for photoacoustic tracking of stem cell,FP7,31 March 2016,01 April 2014,221606.0 NANOSTIR,Tulln Agricultural Technical College * Landwirtschaftliche Fachschule Tulln,energy,"NANOSTIR represents a completely new and highly innovative, alternative polygeneration energy system. It does combine a solid biofuel boiler, a small power range Stirling engine (generating approx. 1 kW electrical power and approx. 10 kW thermal energy) and an absorption cooling machine (generating approx. 15 - 20 kW cooling energy) to a concise and highly potential energy provision system. NANOSTIR significantly reduces former problems of Stirling engines with soiling and slagging of the primary heat exchanger and the resulting performance inefficiencies by using solid biofuels by means of the applied nanotechnological coating material and does so represent a further, energy saving step in the development and application of this technology. NANOSTIR provides a new and highly promising solution attempt for an optimisation of small scale CHP Stirling units and does not only consolidate regional economical cycles and added value in the related regions by boosting forestry, agriculture, transport- and trade",Optimisation of solid biofuel operated Stirling CHP units by means of nano technological coatings,FP6,14 January 2011,15 January 2008,298269.5 NANOSTRBIOSENS,Scientific and Technological Research Council of Turkey * Türkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK),manufacturing,"Most commercially available optical biosensors only measure changes in the refractive index of a solution very near the sensor surface. Information given by this approach is limited to the amount of analyte molecules linked into receptors on the sensor surface. In some cases, understanding complex bio-events is constrained when available data is based solely on refractive-index-change measurements via characteristics of the reflected light (intensity, polarization or phase). Scattering measurements need to be accompanied along with reflection measurements in order to determine the organization of molecules on a surface as well. This proposal calls for the development of nanostructured waveguides made of a thin layer of alumina (Al2O3) which would produce and control dual sensor outputs, specifically, total internal reflection (TIR) and surface enhanced Raman scattering (SERS) signals. Single-mode waveguides with structured surface will present a significant advantage over current optical biosensors by providing better information about both the binding and organization of protein molecules via polarization maintained reflection and scattering. After atomic layer deposition of single-mode waveguide alumina film, its surface modification will be done by a mechanics driven fabrication method called thermal stress induced hillock formation. The main objective of this proposal is to fabricate and characterize a nanostructured alumina waveguide that will provide the following crucial advantages over the optical biosensor approach: 1) The possibility for dual-output with fine tuning, 2) a more complete understanding about the organization of molecules, 3) an unprecedented sensitivity for a label-free optical sensor, which will analyze information down to sub pmol/cm2 because of its enhanced electromagnetic (EM) field, and 4) the ability to control the molecular binding characteristics of the surface.",NANOSTRUCTURED ALUMINA WAVEGUIDES FOR DUAL-OUTPUT BIOSENSING: STRESS INDUCED FABRICATION AND CHARACTERIZATION,FP7,01 July 2017,02 January 2011,100000.0 NANOSTREAMS,Queen's University Belfast,information and communications technology,"NanoStreams co-designs a micro-server architecture and software stack that address the unique challenges of hybrid transactional-analytical workloads, which are encountered by emerging applications of real-time big-data analytics. To this end, NanoStreams brings together embedded system design principles, application-specific compilers, and HPC software practices.",NanoStreams: A Hardware and Software Stack for Real-Time Analytics on Fast Data Streams,FP7,08 July 2018,09 January 2013,0.0 NANOSURF,Trinity College Dublin,information and communications technology,"This proposal aims to probe the surface energetics of low dimensional nanomaterials (LDNs). Materials on this scale show immense promise (mechanically, electrically, thermally, etc.) but to realise this potential they must first overcome their tendency to aggregate. Measuring and understanding the surface energy of such nanomaterials is of vital importance if one wishes to produce solutions of exfoliated LDNs and thus harness their full potential in composites, or devices.",Surface Energetics of Low Dimensional Nanostructures,FP7,08 July 2018,03 January 2013,0.0 NANOSURFS,Technical University of Munich * Technische Universität München,manufacturing,"Inspired by the diverse functionalities of complex molecular building blocks evidenced in manifold life processes as transport of respiratory gases, metabolism or light harvesting, we aim for a comprehensive characterization and control of molecular properties in surface-based model systems. To fully exploit and tune molecular functionality on substrates, a paradigm shift away from conventional metal supports, which might drastically affect adsorbates, is mandatory. We propose to apply nanostructured boron nitride (BN) monolayers and sp2-heterostructures as templates for molecular units and architectures. As indicated by the fascinating nanomesh interface and the electronically corrugated atomically thin BN sheet on Cu we recently reported, inert, temperature stable and insulating BN has a huge potential as advanced substrate supporting molecular functionality, self-ordering and intercalation.",Nanostructured Surfaces: Molecular Functionality on advanced sp2-bonded substrates,FP7,03 July 2021,04 January 2014,0.0 NANOSUSTAIN,NordMiljö O. Grahn AB,environment,"Objective of the NanoSustain project is to develop innovative solutions for the sustainable design, use, recycling and final treatment of nanotechnology-based products This will be achieved by a comprehensive data gathering and generation of relevant missing data, as well as their evaluation and validation, for specific nanoproducts or product groups in relation to their human health and environmental hazards and possible impacts that may occur during after-production stages. Although production of nanomaterials is rapidly increasing, our knowledge about possible health and environmental effects associated with these materials is still rather poor. This lack of knowledge calls for more research. Due to their small size, nanoparticles behave different than their chemical analogues. They can be taken up easily and in a unique way with possible adverse effects in man and organisms. Assessing their hazard is complex and needs new approaches and a close international cooperation. NanoSustain will address the questions, (1) how and to what degree society and the environment will be exposed to nanomaterials and associated products, and (2) where do these particles end up? Expected results will improve our present knowledge on the impact and fate of these particles after entering economic and natural cycles. NanoSustain has mobilized the critical mass of expertise, resources and skills to tackle this complex issue. Based on results from hazard characterization, impact assessment and LCA, we will explore on a lab-scale new solutions for the design of selected nanomaterials and associated products and their sustainable use, recycling and final treatment. As the concerned nanotech industry will actively participate in the planned project, NanoSustain will set the ground for the development of new sustainable products and industrial applications, and hence help to strengthen competitiveness of the European nanotechnology industry.",Development of sustainable solutions for nanotechnology-based products based on hazard characterization and LCA,FP7,05 July 2015,05 January 2010,2475054.4 NANOSWITCH,Aarhus University * Aarhus Universitet,information and communications technology,"The fabrication of conventional microchips is today close to reaching its lower limits concerning the possibleminimization of electric circuits by standard lithographic methods on silicon, a fact referred to as \\andquot;the end of thesilicon road\\andquot;. To further decrease the size of microelectronic circuits and therewith increase the density of logicalunits per chip new ways have to be found to build smaller devices. The greatest prospect for succeeding in thistask lies in nanoelectronics, where the basic logical units are formed of nano-scale objects. One possibility is touse interconnected molecules adsorbed on surfaces for such nanodevices.Scanning Tunneling Microscopy and Scanning Tunneling Spectroscopy at low temperature will be performed onorganic molecules to better understand their arrangement on the surface, possible template creation and theconnection to the surface as well as the conduction through the molecule when assembled into nanowires.Furthermore, vibrational spectroscopy shall be used to investigate the switching behaviour of molecules andallow better judgement whether they are suited for future electronic components.Nanoscience is a young and very promising field due to the expected future applications in nanotechnology. Theshaping of these research fields is a great challenge both to the European Community, which assumes acoordinating role, and the individual researcher, who works at the frontier of current knowledge. After the twoyears of the proposed project, the expertise in nanoscience of the research fellow will be greatly expanded,leaving her with bright prospects for a future career. The new input that both parties, host and researcher, willgain from each other will be stimulating to the advancement of the field. The synergistic interplay willundoubtedly be the source of novel approaches, which will promote the project and thereby the scientificexcellence of both the project parties and the #",Scanning Tunneling Microscopy studies of nanowires and nanoswitches built from organic molecules,FP6,30 September 2006,01 October 2004,179001.0 NANOSYM,University of Cambridge,photonics,"The aim of the proposed research is to use novel Monte Carlo simulation techniques in order to gain insight into the factors that control the nucleation and growth of crystals of charged nano-colloids. Recent experiments (Shevchenko et al, Nature 439, 55(2006)) have shown that it is possible to grow a wealth of different crystal structures from binary mixtures of charged nano-colloids. However, the factors that determine which crystals will grow and which ones will remain microscopic in size are, at present, not understood. It is clear that both the charge and the size ratio of the nano-colloids plays a role. We aim to use a combination of different simulation techniques to predict the stability and nucleation barrier of such nano-colloidal crystals. Understanding these factors is important because nano-particle crystals can find applications in nanoelectronics, plasmonics, high-density data storage, catalysis, and biomedical materials. In our study, we will developed suitable models for the interaction between the nano-colloids. Subsequently, we will use a combination of various computational schemes (umbrella sampling, parallel tempering, forward flux sampling), to compute the barrier that determines the rate of crystal nucleation and the free energy of possible (meta)stable intermediates.",Simulation of directed self-assembly of nanocrystals.,FP7,06 June 2011,07 June 2009,160658.0 NANOSYM,Institute of Tropical Medicine * Prins Leopold Instituut voor Tropische Geneeskunde,health,"The tsetse fly (Glossina spp.) salivary gland is the final micro-environment where the Trypanosoma brucei parasites adhere and undergo a complex re-programming cycle resulting in an end stage that is re-programmed to continue its life cycle in a new mammalian host. The molecular parasite-vector communications that orchestrate this trypanosome development in tsetse fly salivary glands remain unknown mainly due to the limited availability of experimental tools for functional research. We hypothesize that an innovative paratransgenic approach using the Sodalis glossinidius endosymbiont to deliver Nanobodies that target the trypanosome-tsetse fly crosstalk will open a new avenue to unravel the molecular determinants of this specific parasite-vector association. In this project I will develop an innovative Sodalis-based internal delivery system for Nanobodies to target the tsetse fly -trypanosome interplay and, as final outcome, will generate a trypanosome-resistant tsetse fly. In addition, I will explore the completely 'unknown' of the molecular nature of trypanosome adherence to the salivary gland epithelium. This will be addressed by a challenging proteomic-based approach on the tsetse salivary gland - trypanosome membrane complex and by the newly developed paratransgenic approach using the S. glossinidius endosymbiont as an internal delivery system for salivary gland epithelium-targeting Nanobodies. The application of this innovative concept of using pathogen-targeting Nanobodies delivered by insect symbiotic bacteria could be extended to other vector-pathogen systems such as Anopheles gambiae -Plasmodium falciparum and Aedes aegypti -dengue virus.",Symbiotic bacteria as a delivery system for Nanobodies that target the insect-parasite interplay,FP7,31 October 2016,01 November 2011,1444370.0 NANOSYS,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"Nanosystems are integrated systems exploiting nanoelectronic devices. In particular, this proposal considers silicon nanowire and carbon nanotube technologies as replacement/enhancement of current silicon technologies. This proposal addresses high-risk, high-reward research, unique in its kind. The broad objective of this proposal is to study system organization, architectures and design tools which, based on a deep understanding and abstraction of the manufacturing technologies, allow us to realize nanosystems that outperform current integrated systems in terms of capabilities and performance. Thus this proposal will address modelling of technological aspects, synthesis and optimization of information processing functions from high-level specifications into the nanofabric, and new design technologies for specific aspects of nanosystems including, but not limited to, sensing and interfacing with the environment. This proposal will address also cross-cutting design goals such as ultra-low power and high-dependability design, with the overall objective of realizing nanosystems that are autonomous (w.r. to energy consumption) and autonomic (i.e., self healing). The scientific novelty of this proposal stems from the use of a nanofabric, where computation, sensing and communication are supported by a homogeneous means as well as from the study of algorithmic tools for mapping high-level functions onto the nanofabric. The intrinsic benefit of this research is to provide a design flow that extends both the technological basis and the capabilities of integrated systems, thus strengthening the industrial European position in a key sector where disruptive innovation is key for survival. The extrinsic benefit of this research is to broaden the use of nanosystems to new domains, including mobile/distributed embedded systems, health/environment management, and other areas that are critical to our lives.","Nanosystems: Architectures, Design and Applications",FP7,12 July 2017,04 January 2010,2499594.0 NANOTAR,Technion Israel Institute of Technology,health,"The present plan aims to build up and consolidate a research program in Pharmaceutical Nanomaterials Science based on the design, synthesis and chemical characterization of novel self-assembly polymeric nano-biomaterials and the investigation of the relationship between the nano/microstructure and the properties and new processing methods for the improvement of the biopharmaceutic performance of drugs. While the long-term goal of my research plan at the Technion is to develop versatile platforms for various therapeutic applications, the present proposal is oriented to make a substantial contribution to improve the treatment of two infectious diseases, the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and tuberculosis (TB), by developing innovative products that overcome important limitations of the products currently on the market such as poor oral bioavailability and frequent administration. The emphasis of the proposal is on the design, synthesis, processing and comprehensive characterization of the nano-biomaterials and the preliminary assessment of their biological performance in vitro and in vivo. It is a mid-to-long term of this proposal to facilitate the integration of my new research group to a multidisciplinary European network that will address challenges in HIV and TB. The specific aims of the proposal are the development of three types of novel self-assembly nano-biomaterials and the preliminary characterization of the in vivo performance of the systems with optimal properties: Aim 1-Development of alkoxysilane-grafted polymeric amphiphiles. Aim 2-Development of polymeric amphiphiles conjugated with mono- and oligosaccharide residues. Aim 3-Development of muco-adhesive polymeric micelles. The different drug delivery systems are planned in a modular approach to enable the production of multifunctional drug nanocarriers with various features (e.g., drug encapsulation ability, muco-adhesivness, etc.).",SELF-ASSEMBLY POLYMERIC NANO-BIOMATERIALS FOR DRUG DELIVERY AND TARGETING,FP7,28 February 2018,01 March 2014,100000.0 NANOTEC,Thales SA,information and communications technology,RF communication and remote sensing (radar/radiometric) systems are facing the demands of,Nanostructured materials and RF-MEMS RFIC/MMIC technologies for highly adaptive and reliable RF systems,FP7,07 July 2017,09 January 2011,0.0 NANOTECH FTM,"Faculty of Technology and Metallurgy, University of Belgrade",construction,"In recent years, the advance of contemporary technologies became more closely related to the development of new materials. Exploiting the possibility of designing new materials on micro and nano level as well as composite materials enables their use in various fields such as biomedicine, catalysis, civil engineering, aerospace and process industry. The aim of this project is to contribute to the advance in proposed fields by networking and reinforcing research centers in Serbia as an EU's Convergence Region, by organizing personnel exchange, performing joint experiments, teaching and training activities with EU networking research and industrial partners. In that way, the research project team will get strong expertise in the synthesis, processing, characterization and testing of nanostructured materials, establishing new advanced processing and characterization methods, also. Special care will be taken towards hiring of experienced and new young researchers in order to reinforce the human potential. This project will also result in upgrading and acquired of the S&T equipment of the centre in order to reinforce internal S&T capacities. This kind of collaboration will result in preparing further cooperative activities and preparation of new joint RTD proposals and reinforcing integration to European Research Area.",Reinforcing of Nanotechnology and Functional Materials Centre,FP7,12 July 2014,01 January 2010,1298774.0 NANOTECHNOLOGYMETAST,Technion Israel Institute of Technology,health,"Metastasis -the spread of cancer to distant organs, poses a great therapeutic challenge. Nanomaterials have many therapeutic advantages, such as the ability to target specific tissues and carry multiple drugs, making them promising candidates for treating metastasis. Despite the great need, there is a gap in the fundamental understanding what structural parameters can enhance the targeting capacity of nanomaterials to metastatic sites. This program is aimed at elucidating the mechanism by which therapeutic nanomaterials can be designed to target and treat metastatic cancer.",TREATING METASTATIC CANCER WITH NANOTECHNOLOGY,FP7,31 March 2017,01 April 2013,100000.0 NANOTECHPINNINGHTS,University of Birmingham,health,"The project is in the frame of nanotechnology for materials and surfaces and is a multidisciplinary one, involving nanotechnology, surface science, materials science, and superconductivity. The subject is the creation and study of strong pinning centres in high-critical temperature superconducting (HTS) thin films, devices, and coated conductors (CC), induced by self-assembled three-dimensional (3D) nano-scale islands of various materials grown on substrates prior to HTS film deposition. Preliminary results proved this method to be straightforward and cost-effective in blocking the thermally activated motion of magnetic flux lines in HTS, motion that is limiting the superconducting (SC) parameters (critical current density, surface resistance in microwave, noise). The aims of the research are the controlled growth of self-assembled 3D nano-dots, structural characterization of nano-dots induced pinning centres and studies of their influence on the SC properties, optimisation of SC properties, and application of the proposed technology for improving the performances of various devices and equipment, ensuring the competitiveness of EU research and technology in this field and strong market penetration of a large number of HTS devices and equipment, like energy efficient equipment for electric power generation, transport and distribution, microwave devices for mobile and satellite communication, high-sensitivity magnetic field detectors for medicine and non-destructive evaluation. The project will be undertaken at University of Birmingham, with excellent facilities and world-wide recognised expertise and results, will create a team capable of reaching a high level of excellence in pinning engineering in HTS, and will help the creation of an excellent, transnational and stimulating focal point of interdisciplinary research in superconducting films, devices and coated conductors at University of Birmingham.","Self-assembled Nanotechnology of Pinning Centres in Superconducting Films, Devices and Coated Conductors",FP6,30 April 2011,01 May 2007,1601296.16 NANOTEG,Acondicionamiento Tarrasense Associacion,energy,"The concept of NANOTEG is to solve crucial cooling and energy-management issues in transport and energy-efficient applications, based on the technical leverage enabled by highly efficient nanostructured ThermoElectric (TE) modules compatible with high volume fabrication processes. Seven relevant industrial demonstrators will be produced to create a strong impact in 4 identified application domains: Automotive, Avionics, Power inverters for UPS and motor drive, LED-Lighting. This main objective is supported by the development of two technical pillars: Nanostructured TE materials that are highly efficient (high ZT) and compatible with existing high volume fabrication process. Several routes of applied research will be developed on nanostructured TE modules combining different fabrication processes, all industry-scalable (sputtering, atomic layer deposition, nanocomposite), materials (Bi2Te3, perovskite, metal-oxides, skutterudite) and 'nano-approaches' (superlattices, nanoinclusions) Innovative packaging and integration solutions, allowing the integration of the nano-TE materials into highly efficient modules (high CoP) at the core of the system-level demonstrators. Innovative applied research on integration, packaging and interconnect technologies will be developed to guarantee the high efficiency of the TE modules and ensure the short time to market implementation of the project results. To satisfy different end-user needs, different packaging concepts (internal or external TEC integration), geometries, Thermal Interface Materials, underfilling and interconnect technologies will be developed in complete accordance to each demonstrator specifications. The NANOTEG consortium (21 partners from 9 European ENIAC-member States) gathers all the competences required to achieve these objectives. It is well balanced and involves all the supply chain partners in order to anticipate the cost-effective introduction of these new technologies and future products on the market.",Nanostructured ThermoElectric Systems for Green Transport & Energy Efficient Applications,FP7,01 June 2014,01 July 2011,1016910.0 NANOTEMP,Lancaster University,information and communications technology,"Developments in low temperature technology heave reached the point where temperatures around 1 mK can be reached in commercially available systems, typically based on a 3He-4He dilution refrigerator. In the lab, nuclear demagnetisation refrigeration pushes this boundary lower: nuclear spin systems have been cooled to the nanokelvin regime, while the lowest temperature ever measured for electrons in a material is around 10 microkelvin.",Nanoscale Devices for Ultralow Temperature Thermometry,FP7,07 July 2019,08 January 2013,0.0 NANOTEMPLATES,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"NanoTemplates STREPS project will push the Frontiers of Science of a unique range of nano- objects made by further extending nanotechnology developed in two EU RTD projects [NanoPTMS & GMR - BE95-1761 & NanoPTT - G5RD -CT1999-00135]. It will seek advantageous property discontinuities arising from the nano-regime and explore these through a range of novel nano-systems to identify promising areas for further development. The project will be underpinned by IPR from previous EC projects employing UCL technology based on heavy ion bombardment and track etching of polymers for nano-object fabrication. Fundamental studies of the track etching and patterning processes will be made. Nanoporous substrates (pores down to 10nm), polymeric and metallic nanowires and nanotubes in various forms (Nano-objects), including particulate and embedded within coatings and self-supporting films, will be developed (UCL, Epigem, CNRS). Alternative route to nanoporous arrays will also be investigated by using AFM tip generation of pores (CNRS) in spin-coated films. The characterisation of the nano-objects will be performed and specific properties will be measured. It is intended to screen optical, magnetic and chemical properties. The response of magnetic metallic nanowire arrays to high frequency fields will be investigated (Thales, UCL), whilst CRF and Thales will explore the magnetic properties of the nano-structures. Spin dependent phenomena in magnetic nano-objects will be investigated by UCL and CNRS to explore ultimate limits of magnetoresistive effects and potential long- term applications to quantum computing. UNEW and Epigem will integrate nano-objects in microfluid nanosystems and measure biomedical properties. CRF and Durham will explore nano-objects in the form of light sources comprising light emitting polymer diodes (OLED). Confinement effects will be explored to identify benefits for the emission spectrum as well as the light extraction mechanism.","Templates for Engineered Nano-Objects for use in Microwave, Electronic Devices and Biomedical Sensing Applications",FP6,31 August 2007,01 September 2004,1500000.0 NANOTEST,Norwegian Institute for Air Research * Norsk Institutt for Luftforskning,health,"Nanoparticles (NP) have unique, potentially beneficial properties, but their possible impact on human health has not been adequately assessed. The main goal of this proposal is to develop alternative high-throughput testing strategies using in vitro and in silico methods to assess the toxicological profile of NP used in medical diagnostics. Our specific aims are to: 1. Define NP properties and fully characterize NP to be used 2. Study NP interactions with molecules, cells and organs and develop in vitro methods to study the toxicological potential of NP 3. Validate in vitro findings in short-term in vivo models and study particle effects in animals and (ex vivo) in humans to assess individual susceptibility to NP 4. Develop in silico models of NP interactions Experimental work is structured in 4 WPs to address NP characterisation and key elements in evaluation of NP uptake, exposure and toxicology. NANOTEST integrates the investigation of toxicological properties and effects of NP in several target systems by developing a battery of in vitro assays using cell cultures, organotypic cell culture and small organ fragments (ex vivo) derived from different biological systems; blood, vascular system, liver, lung, placenta, digestive and central nervous systems. As NP action is likely to involve oxidative stress we will focus on the cross-cutting areas of inflammation, cellular toxicity, immunotoxicity, genotoxicity and related endpoints. Following development of SOP and generation of a common database and in parallel with in silico assays (QSAR, PBPK modelling), NanoTest will evaluate toxic effects and interactions of NP used in nanomedicine. Results will be validated in an experimental ethically approved in vivo model. The most advanced and standardised techniques will be adapted for automation and prepared for validation by ECVAM. Separate WPs will be dedicated to dissemination and to effective administrative and scientific management.",Development of methodology for alternative testing strategies for the assessment of the toxicological profile of nanoparticles used in medical diagnostics,FP7,31 March 2012,01 April 2008,2994383.0 NANOTESTS,IMDEA Nanoscience Institute * IMDEA Nanociencia,health,"Bacterial resistance to antibiotics is one of medicine's most vexing challenges. Most antibiotics initially work really well, killing more than 99.9% of microbes they target. But through mutation and the selection pressure exerted by the antibiotic, a few inevitably manage to survive, and flourish as antibiotic-resistant strains. Hence, new strategies to design antibiotic to combat drug-resistant bacteria are required. Many drug delivery systems based on nanomaterials have been developed during the last decade, being the toxicology of these materials into single bacteria still not thoroughly evaluated due to the lack of reliable techniques to confine individual microbes. Prof. Whitesides' group in Harvard University (USA) is undoubtedly a world leader in this area, as it has a high international profile earned through many key contributions about novel nanofabrication methods for microbiological applications during the last 20 years. Prof. Miranda and Prof. Carrascosa (both from IMDEA Nanoscience-Spain) are the leaders of research groups working in collaboration for (i) the development of novel antibiotic strategies based on drug delivery nano-systems and (ii) biophysical aspects of cell mechanics, self-assembly properties of organic heterostructures and supramolecular nanomachines. The time is ripe to integrate the various strategies developed by Prof. Whitesides' group to confine single living bacteria with the novel strategies for drug delivery that are being developed at IMDEA Nanoscience-Spain. The aim of the present OIF includes consolidating IMDEA expertise in the toxicological effect of nanoparticle based drug carriers into individual bacteria in order to develop a novel set of antibiotics for treatment of multi drug-resistant bacteria and to contribute to fundamental questions about bacterial biology, such as cell wall biophysics, chemical bonding and DNA conformational dynamics.",Fabrication and development of nanotoxicology-test bacterial arrays for the investigation of antibiotics against multi drug-resistant bacteria.,FP7,28 February 2015,01 March 2012,223669.0 NANOTESULPHIDE,HENAN POLYTECHNIC UNIVERSITY,energy,"Thermoelectric (TE) power generation, which offers potential for converting waste industrial heat into useful electricity, is foreseen to become increasingly important in the near future because of the need for alternative energy sources. How big this role is likely to be depends not only on the efficiency of TE materials but also on the crustal abundance and toxicity of their raw materials. BiSbTe intermetallic compounds, PbTe and SiGe alloys have served as the most widely used TE materials in the past half century. However, the key constituent elements, such as Te (0.001 ppm by weight), Sb (0.2 ppm), and Ge (1.4 ppm) are rare in the Earth's crust, and Te and Pb are toxic. In this project, TE sulphides operating in the medium temperature ranges, instead of tellurides are chosen as the research starting point to explore TE materials with high figure of merit zT, which requires higher Seebeck coefficient, higher electrical conductivity, and lower thermal conductivity. A combination of band structure engineering and nanostructuring will be simultaneously investigated as an effective approach for improving TE performance. We will identify promising optimized compositions and sinter powders by Spark Plasma Sintering (SPS) to produce three kinds of TE metal (Cu, Bi, Ti) sulphides. Also, grain size and morphology controllable bulk nanomaterials will be fabricated by nonequilibrium routes, for example, melt spinning or mechanical alloying followed by SPS. The main objective of this work is to develop high performance nanostructured TE sulphides and modules to replace current commercial materials that use costly, scarce and toxic elements. Moreover, this project will help to clarify the physical mechanisms behinds the two strategies, band structure engineering and nanostructuring. The effect of thermodynamic process of the nonequilibrium preparation route on the electrical and thermal properties will be studied and the mechanisms involved will be established.",Spark Plasma Sintering Nanostructured Thermoelectric Sulphides,FP7,,,15000.0 NANOTESULPHIDE,Queen Mary University of London,energy,"Thermoelectric (TE) power generation, which offers potential for converting waste industrial heat into useful electricity, is foreseen to become increasingly important in the near future because of the need for alternative energy sources. How big this role is likely to be depends not only on the efficiency of TE materials but also on the crustal abundance and toxicity of their raw materials. BiSbTe intermetallic compounds, PbTe and SiGe alloys have served as the most widely used TE materials in the past half century. However, the key constituent elements, such as Te (0.001 ppm by weight), Sb (0.2 ppm), and Ge (1.4 ppm) are rare in the Earth's crust, and Te and Pb are toxic. In this project, TE sulphides operating in the medium temperature ranges, instead of tellurides are chosen as the research starting point to explore TE materials with high figure of merit zT, which requires higher Seebeck coefficient, higher electrical conductivity, and lower thermal conductivity. A combination of band structure engineering and nanostructuring will be simultaneously investigated as an effective approach for improving TE performance. We will identify promising optimized compositions and sinter powders by Spark Plasma Sintering (SPS) to produce three kinds of TE metal (Cu, Bi, Ti) sulphides. Also, grain size and morphology controllable bulk nanomaterials will be fabricated by nonequilibrium routes, for example, melt spinning or mechanical alloying followed by SPS. The main objective of this work is to develop high performance nanostructured TE sulphides and modules to replace current commercial materials that use costly, scarce and toxic elements. Moreover, this project will help to clarify the physical mechanisms behinds the two strategies, band structure engineering and nanostructuring. The effect of thermodynamic process of the nonequilibrium preparation route on the electrical and thermal properties will be studied and the mechanisms involved will be established.",Spark Plasma Sintering Nanostructured Thermoelectric Sulphides,FP7,30 July 2016,31 July 2014,309235.0 NANOTHER,Fundación Gaiker,health,"The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.",Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer,FP7,31 August 2012,01 September 2008,8408483.0 NANOTHERAPY,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"The essence of the proposal is the fabrication of multiple nano containers which exhibit double and triple stimuli response and site recognition. Specifically, the containers will be grafted by Leuprolide (LP) for prostate cancer recognition. Multiple containers will be filled by two drugs (e.g. LP and DOX) in different compartments not interacting with each other chemically (cocktail of drugs, e.g. Container1 Leuprolide (LP) and Container2 Doxorubicin (DOX)). The release can be excited by internal or external stimuli response. The internal stimuli response of our nanocontainers will require simultaneous recognition of pH, redox and/or T of the tumour. The external induction will be caused by RF excitation (hyperthermia). The nanocontainers will identify the tumour first by the agonist (LP). After trapping the container at the tumour, they will be activated by the double and triple internal excitation. This way, we achieve extremely local chemotherapy of the diseased site and the healthy organs will be untouched. Our smart nanocontainers will be tuned for prostate cancer, but our system will be evaluated for other cases such as breast cancer and thrombosis. The containers will be modified (phase transition, volume change, degradation, etc.) and deliver the drug only and if only the two sensors give positive response. The containers can be excited by external induction (Radio Frequency (hyperthermia) RF or laser light). This revolutionary strategy is necessary because the externally induced delivery methods have the disadvantage that the radiofrequency fields, the magnetic fields and the laser lights are not local but they extend over large space, larger than the size of the tumour. One cannot focus from outside the laser beam directly to the tumour only may be due to lack of imaging facilities. Our technology will prevent the release of drugs in sites where the local values correspond to the healthy tissue.",A Novel Nano-container drug carrier for targeted treatment of prostate cancer,FP7,31 January 2014,01 February 2009,2000000.0 NANOTHERAPY,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"The clinical use and effect of most conventional therapies (e.g. for cancer) are limited, either due to insufficient accumulation of the drug in the target tissue or its severe toxic effects on healthy tissues. Consequently, many treatments are not achieving their full effect and many other highly promising compounds never make it to the market. A promising approach to address this issue of bioavailability is the design and development of nanocarriers. These nanocarriers need to provide stable protection of the compound in the blood stream while they should release the compound at the targeted tissue. Currently, there are no nanocarriers available that effectively address this challenging trade-off. We have constructed nanocontainers (NCs) that show high promise to address this issue. Our NCs are engineered from biocompatible and biodegradable polymers and are unique in their stability and resistance to drug leakage in the circulation, while they exert conformational changes under specific conditions targeting at the pathological tissue, inducing localised drug release. This technology leverages the fact that tumours (as well as other types of diseased tissue) are known to have specific extracellular environments with lower pH, higher temperature and enhanced glutathione levels compared to healthy tissues. Our NCs integrate four stimuli, namely pH, temperature (T), reducing environments (glutathione) and alternating magnetic fields. With the PoC grant we aim at obtaining in vivo evidence of the functional added value of our proprietary NCs for the delivery of anti-tumour and antibacterial drugs. Furthermore, we aim to strengthen our IP position and develop a business plan thatdescribes theoptimal route-to-market for our technology.",A Novel Nanocontainer drug carrier for targeted treatment of cancer,FP7,31 December 2014,01 January 2014,150000.0 NANOTHERM,Thales SA,information and communications technology,"Future electronic power devices and packages will need to demonstrate more performance and functionality at reduced cost, size, weight, energy consumption and thermal budget. Further, increasing reliability demands have also to be met by industry to be competitive in this growing multi-billion Euro market of heterogeneously integrated systems.To respond to these challenges, new innovative nano- and micro-technologies and materials, both of which are key enablers for advanced thermal and mechanical interfaces, have to be developed and compatibly integrated to obtain higher electrical, thermal and reliability performance under harsh environmental conditions.Nanotherm’s objective is to take up these challenges in design, technology and test:Novel approaches to thermal technologies with superior electrical, thermal and thermo-mechanical properties will be developed in the project and demonstrated on automotive, avionics, solid-state lighting and industrial applications. Parallel routes will be followed addressing nano-sinter-adhesive bonding, phonon-coupled VACNT joining, nano-functionalised nano-filled adhesive die attach and graphene-enhanced surfaces. The main principle common to all technologies is the exploitation of nano-effects to obtain outstanding interconnect properties by especially developed processes.In parallel, a multi-scale and multi-domain modelling framework will furnish guidelines for materials design by various approaches from ab-inito up to continuum modelling and verified by corresponding experimental techniques.The consortium, composed of 18 partners from industry, SME and academia out of 8 European countries, embodies the necessary excellence and interdisciplinarity to address these tasks successfully. We are convinced that Nanotherm’s results will enable the next generation of heterogeneously integrated power packages, cut down thermal interface resistance at least by 50% and impact also on other power system-in-package configurations.",Innovative Nano and Micro Technologies for Advanced Thermo and Mechanical Interfaces,FP7,08 July 2017,09 January 2012,6070000.0 NANOTI,Ateknea Solutions Hungary Kft.,health,"Infections associated with dental implants may cause peri-implantitis often resulting in implant loss and impaired function. Recent studies show an alarming increase in the incidence of the infections, while on the other hand the efficacy of the prevailing treatment method is decreasing due to the rising resistance of micro-organisms to antibacterial agents. The SMEs of the NanoTi consortium intend to bring a new titanium implant to the market that possesses the innate capability to resist bacterial infections without the addition of any antibacterial compound. In order to reach this goal the aim of the NanoTi project is to develop nanophase topography on the surface of titanium dental implants that will enable such an effect. This nanophase topography: • Reduces the susceptibility of titanium dental implants for infections; • Enables the surgical decontamination of implants if infection occurs; • Supports bone healing around the dental implant.",Development of a titanium dental implant with superior antibacterial properties,FP7,31 January 2016,01 February 2014,863000.0 NANOTIME,Graduate School of Electricity * École Supérieure d'Électricité (SUPELEC),health,"The NANOTIME project relies on a bipolar competence: that of a recognised research laboratory (founded in 1968); and that of a high level engineering institute (founded in 1894). Moreover, the research field targeted 'terahertz imaging' involves multidisciplinary issues such as materials sciences and nanotechnologies, electromagnetics or electronic circuits design, astronomy (in the planet atmospheres or interstellar matter areas), environment on both pollution and climate contexts, energy in the renewable sources area (plasma diagnoses for atomic fusion), transportation (air and marine navigation), security of the civilians (in the concealed weapons or fraud products or fire alarm areas), vegetal (leaf degradation) or animal (food quality) or human disease (tooth decay) diagnoses, as well. We are proposing a monosite project that also involves interrelated groups to form an excellence pole. The core of it will be located at Supélec (École supérieure d’électricité), which is a leading engineering institute having a very special position due to its private status and its privileged links with public education and research entities. Supélec hosts the LGEP (Paris Electrical Engineering Laboratory), which is leading the project. To NANOTIME other research groups will be implied, as well as the SME SATIMO whose competence relies on electromagnetic characterization. What does bring this project, to the level of a comprehensive training project, is Supélec’s belonging to the TIME association that includes Supélec with 40 other higher education European institutions, to promote collaboration in training and research. The NANOTIME pole aims at (i) creating an “Ile-de-France†competence devoted to the training of young scientists in a hot topic research field, (ii) developing a scientific breeding ground to preserve a know-how acquired by the actors of the project for a long period of time and (iii) preventing the brain drain from Europe to other locations in",NANostructures of Oxides for Terahertz IMaging Exploration,FP6,30 November 2009,01 December 2005,926209.41 NANOTIMER,NXP Semiconductors Netherlands BV,information and communications technology,"Mechanical resonance is widely applied in high-precision oscillators for a multitude of time-keeping and frequency reference applications. In all such cases, the high-precision resonatingelement consists of an off-chip passive component, such as a quartz crystal. Major drawbackof these off-chip resonator technologies is that they are bulky and must interface withtransistor chips at the boards, posing a bottleneck against the ultimate miniaturization of e.g.wireless devices. The extraordinary small size and high level of integration that can beachieved with silicon MEMS resonators appear to open exceptional possibilities for creatingminiature-scale precision oscillators to be used in e.g. mobile communication and navigationdevices. The aim of the NanoTIMER project is to develop an oscillator with high-accuracyincorporating a silicon MEMS resonator generating frequencies in the 10 to 1500 MHz range.Within the NanoTIMER project, MEMS based oscillators will be realized according to concretespecifications derived from existing applications. The MEMS oscillator will be encapsulatedusing a wafer-level vacuum package technology that is compatible to the oscillatormanufacturing flow. An important feature of the proposed resonator manufacturing process isthe realization of nanometre size (100 nm) transduction gaps, which is of prime importancefor the realization of MEMS resonators functioning in the GHz range. Reliability and drift ofassembled oscillators and its constituent components (resonator and package) will beassessed.The NanoTIMER initiative is a first step towards the realization of 'vibrating' nano-electro-mechanical processors that, combined with traditional CMOS, could open new alternatives forsignal processing in VLSI.",NanoTIMER - Nano-technology in mechanical-electrical resonators,FP6,30 September 2007,30 December 2003,2300000.0 NANOTOES,University of Salzburg * Paris Lodron Universität Salzburg,health,"Life Sciences and Nano Sciences interact today mainly in two areas: in the evaluation of accidental health and environmental effects derived from engineered nanomaterials, and in development and biological/clinical evaluation of nanoparticles with intended biological effects for application in medicine and biotechnology. It is essential for producers, distributors, consumers and regulators that the safety of products containing nanomaterials can be certified with reliable, validated assays. Research efforts are under way to establish suitable test methods and to understand mechanisms potentially leading to a detrimental impact of nanomaterials on human health and on the environment. However, this important field still urgently lacks sufficient trained personnel. The ITN 'Nanotechnology: Training Of Experts in Safety' (NanoTOES) will establish a network of research projects working towards the refinement and standardisation of existing methods, will develop novel assays, and will during this process provide interdisciplinary training to Early Stage Researchers (ESR) and Experienced Researchers (ER) working at the intersection of biosciences and nanosciences. A suite of methods developed and validated in the NanoTOES project shall have utility in characterising the biological effects of nanomaterials, including their impact on the environment, and will add significantly to our understanding of the biological actions of nanomaterials and their resultant effects on human health and the environment. Equally, the influence of biological entities (molecules, cells, tissues) on the properties of nanomaterials will be investigated. This aspect is crucial to understanding the properties of nanomaterials in organisms and in the environment, but nevertheless this issue has been so far not sufficiently explored. These timely and novel studies will address the pressing need for such trained personnel, and enable European science in this area to remain globally competitive.",Nanotechnology: Training Of Experts in Safety,FP7,31 October 2014,01 November 2010,3254330.0 NANOTOOL,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The heart of this proposal is to give access for European fellows to interdisciplinary knowledge and training focused on the elaboration and properties of nano-objects (metal nanoparticles, dendrimers and surfactant aggregates). The training site localized at the University Paul Sabatier in Toulouse is composed of three internationally recognized research teams working with a multidisciplinary approach. It will provide to the fellows the common technical and methodological background on three complementary aspects of those nano-objects: 1) the chemical synthesis leading to size and shape controlled nano-objects, 2) the control of their organization and mesostructure in volume or along a surface 3) their properties in catalysis, biology and material science. The training will combine laboratory work focused on a 'cutting edge' research project and lectures. Those lectures (selected academic courses, weekly seminars, talks given by invited world famous scientists and lectures dedicated to the EST fellows) will broaden and deepen the fellow's knowledge in the field, promote innovation and interdisciplinarity and help the trainee's career development. Through the multidisciplinary research project, the fellows will be trained in various chemical syntheses (organochemistry, chemistry of heteroelements, surfactant chemistry), in the characterization of the nano-object mesostructures (they will have access to the most advanced characterization techniques) and in applications of the nanoobjects in connection with societal issues (catalysts for green chemistry, environnemental sensors, drug carriers, transfection, anti-HIV agents for health care issue…).This training will ensure the development of a pool of young scientists having a large multidisciplinary background and able to deal with the challenges of the nanomaterial field. It will increase synergies and collaborations between European research centers and favor the leadership of the European activity in this field.","Synthesis, self-aggregation and properties of nano-objects in chemistry, biology and material science",FP6,31 March 2010,01 April 2006,1151406.55 NANOTOX,Chalex Research Ltd.,health,"The global aim of this project is to provide investigative support for the elucidation of the toxicological impact of nanoparticles on human health and the environment. It is aimed at area 3.4.1.5. of the Nanotechnologies and Nanosciences, Knowledge Based Multifunctional Materials, New Production Processes and Devices work programme. Public organisations and nanotechnology companies across Europe are under pressure to improve the safety of nanoparticles. In this project, they will document potential methods of dispersal and contamination by nanoparticles and agglomerated nanocrystals (e.g. sorption, desorption, transport, aggregation, deposition, bio-uptake). The review will also address the following issues: a)physical and chemical properties of different types of nanoparticles and agglomerated nanocrystals; b)manufacturing and use; c)human health effects including side effects; d)animal toxicology; e)environmental impacts; f)mutagenicity/genotoxicity; g)metabolism/pharmacokinetics; h)standards for safe use; i)safe laboratory methods etc. Current research and development activities in Europe will be mapped and entered onto an on-line European database, which will be linked to existing web sites and databases of specialist groups. Standards, legislation, ethical issues, policies and codes of practice, at international and European level, which have been put in place or are under development, will be assessed and reviewed. Their implications and effectiveness will be discussed. Ways in which existing legislation is applied to the macroscale counterparts of nanoparticles will also be examined. Guidelines and recommendations for the institution of future European standards, legislation, ethics, policies, and codes of practise, for the safe production and use of nanoparticles will be produced. All potential impacts revealed by this SSA will be documented in the final report & disseminated via the specialised webpages on the Nanoforum & Nanotox websites.",Investigative Support for the Elucidation of the Toxicological Impact of Nanoparticles on Human Health and the Environment,FP6,31 January 2007,01 February 2005,399894.0 NANOTOX,National Institute of Occupational Health Denmark (NIOH-DK),health,"Given the current manufacture growth, presence of nano-particles (NP) in the environment and the future use of NP, human exposure is inevitable. Yet, the potential adverse effects on human health from exposure to NP are still largely unknown. This proposal outlines a strategy for determining how the physicochemical properties of NP influence there potential for toxicity at the National Institute of Occupational Health, Denmark and University of Copenhagen. Specifically, a wide range of NP will be characterized for their size, shape, surface area, solubility, and chemical composition. Experiments will be performed with human epithelial cells to determine the NP potential for toxicity by measuring reactive oxygen species (ROS) generation, pro-inflammatory cytokines, apoptosis, and DNA oxidative damage. By comparing the physicochemical properties of NP with their potential for toxicity, we gain the ability to predict the toxicity potential for existing and novel NP exposures. Without safety assessments and clear communication with the public and regulators, nanotechnology and the use of NP could potentially be restricted, which may hinder the economic future of Europe. This research involves the translation of physical science techniques to advance understanding of an important medical issue and mutually benefits from an ongoing and expanding nanotoxicology program at the host institute, which currently includes in vitro, in vivo and hazard evaluation aspects. My career goal is to become active in Medical Geology and Nanotoxicology. This fellowship would prove extremely valuable for my career training and serve as a springboard for future intra-Europe and cross-Atlantic collaborations. By combining several established and novel techniques from various disciplines with a well-defined research plan that is relevant to the work programme and the objectives of the European scientific programme, we are ambitious that our contribution may be significant.",Nano-Particle Characterization and Toxicity,FP6,30 November 2008,01 December 2006,180134.64 NANOTRAC,University of Strathclyde,health,"Nanomedicines are defined as specifically engineered, nanosized drugs and drug delivery systems that are comprised of multiple components. For example, polymer-drug conjugates and drug-protein conjugates are emerging as promising approaches to treating a number of diseases, including cancer. The payloads of these nanomedicines differ widely. However, when targeting cancer, there is a universal requirement to reach the tumour microenvironment and often to deliver the payload to a specific intracellular compartment in order to yield the desired therapeutic effect. The goal of this proposal is to develop two complementary approaches that showcase the manufacturing of functionalised biopolymer-based nanoparticles and their subsequent biological evaluation in relation to cellular and subcellular trafficking in the tumour microenvironment. To achieve this goal, I propose two main aims. Aim 1 is to generate drug-loaded silk nanoparticles that can be readily functionlised to target specific cells and cellular compartments. I hypothesise that by using functionalised silk nanoparticles, it will be possible to target and deliver a therapeutic payload to cancer cells, which will lead to improved clinical outcomes in vivo. Aim 2 is to establish a repertoire of subcellular fractionation techniques in order to quantitatively describe the intracellular fate of nanomedicines in vitro and in vivo. I hypothesise that in particular, subcellular fractionation methods will allow a better understating of the fate of nanoparticles in tumour cells and their subsequent intracellular trafficking. Taken together, these studies will demonstrate an integrated approach to the development of next-generation nanomedicines. This proposal provides the drug delivery field with a novel nanoparticle system and a unique toolbox for the cellular tracing of nanomedicines for the wider scientific community.",Tracing the Intracellular Fate of Anticancer Nanomedicines,FP7,28 February 2017,01 March 2013,100000.0 NANOTRAFFIC,"Swiss Federal Institute of Aquatic Science and Technology * Eidgenössische Anstalt für Wasserversorgung, Abwasserreinigung und Gewässerschutz",environment,"The nanotechnology industry offers many benefits to society, however its potential depends upon the knowledge of its impact on public health and the environment. NPs can enter the body bypassing epithelia, accumulating in spleen, gut, liver and brain as shown in fish as environmental species. While the mechanism of uptake and metabolism of NPs is unknown, their size and physical characteristics suggest that they may enter the epithelia through an endocytotic mechanism. The aim of this study is to investigate the toxic mechanism of metal- (Ag and TiO2) NPs. These NPs were selected for their impact on health and environment due to their commercially widespread use. Specific goals will be investigating NPs kinetics (uptake/trafficking/excretion) by the monitoring of NPs intracellular localization through time using polarized intestinal cells thus enabling the evaluation of apical and basolateral uptake and possible bioaccumulation effects. Toxicity of Ag- and TiO2-NPs will be evaluated by monitoring the incorporation and trafficking of vesicles containing NPs through time using state of the art electron microscopy. In parallel, biochemical and molecular cellular responses will be measured including specific effect on Cu homeostasis. Thus, Cu-ATPase function will be tested by monitoring its trafficking behaviour. In addition, Cu intracellular availability will be measured using molecular markers of Cu availability. The mechanistic knowledge generated in this project is envisioned to support human and environmental risk assessment with regard to metal ion and metal NP exposure. Moreover, the proposed development of the polarized cell line models based on the Caco2 (human) and RTgutGC (fish) cell lines for evaluating mechanism of NP interactions will not only be of great importance from a biological point of view (apical/basolateral uptake) but will also contribute to the efforts to establish animal-free, in vitro alternatives in environmental risk assessment.",Do small things lead to big problems? Mechanism of uptake and toxicity of metal nanoparticles in intestinal cells,FP7,04 June 2016,05 January 2012,186528.8 NANOTRAINFORGROWTH,International Iberian Nanotechnology Laboratory * Laboratorio Ibérico Internacional de Nanotecnología,health,"The INL International Fellowship Programme for Experienced Researchers is set to be a 4 year programme to foster and consolidate the European Research Area (ERA) by attracting talented researchers and developing their careers. INL´s Post-doc fellowship programme is an individual-driven bottom-up approach that comprises the incoming mobility scheme. INL´s international Post-doctoral fellowship programme allows for experienced researchers (from all over the world and nationality) to sketch out a research project and work on their own research idea, at INL´s Facilities. Fellows will have access to a completely new state-of-the-art infrastructure and will have the opportunity to enhance their expertise via a research project, in a scientific topic of their choice, and that is well within INLs strategic research and technological development areas: • Nanomedicine: Drug Delivery systems, molecular diagnosis systems and chips, cell therapies, imaging solutions, regenerative materials, biomolecular labels, synaptic process monitoring, tissue engineering, etc. • Environmental and food control: Nanotechnology applied to Food industry, food safety and environmental control. Water and Soil control, air pollution monitoring, artificial nanopore sensors, lab-on-a-chip technologies, Smart Packaging and labels, food control process, biosensing technologies. • Nanoelectronics: NEMS/MEMS, Spintronics, Photonics, Nanofluidics, Molecular electronics, Organic electronics, Nanotechnologies to support the previous research areas. • Nanomanipulation: Single molecule/atom manipulation, molecular motors, nanotwezzers, Sellf assemby controlled processes of building blocks for nanodevices. INL´s Fellowship Programmes can only fund experienced researchers in possession of a PhD certificate and with less than 10 years of research experience.","INL Fellowship programme in nanotechnologies for biomedical, environment and food applications.",FP7,31 December 2016,01 January 2013,1315954.0 NANOTRAN,Lancaster University,information and communications technology,"The study of molecular nanostructures is in the forefront of research due to their high application potential as electronic components. Recently several theoretical groups have placed large effort into developing new tools to accurately describe the electronic properties of molecular nanostructures. This proposal aims to significantly advance the limits of current capabilities and provide the theoretical tools needed to underpin research in nanoelectronics on a five to ten years timescale. The proposed research focuses on the electronic properties of nanostructures, including single-molecule wires, carbon nanotubes, and other carbon nanostructures, such as functionalized graphene strips. The theoretical tools to be used are based on the non-equilibrium Green's function formalism and density functional theory (DFT). The recently-announced code SMEAGOL (Spin and Molecular Electronics in Atomically Generated Orbital Landscapes) developed by the host institution and collaborators is to be used for the study of transport properties. This code works in conjunction with the localized orbital based, linearly scaling DFT code SIESTA (Spanish Initiative for Electronic Simulations with Thousands of Atoms). Where necessary, these calculations are to be augmented with the plane-wave based VASP (Vienna ab initio simulation pakcage) code, which the applicant has vast experience with. One focus of the project is to incorporate electron-phonon interactions into the SMEAGOL code, to enable the study of room temperature transport properties. Successful completion of the research objectives will yield significant progress in the field of molecular electronics. The impact of the planned research may potentially influence the development of applied science in the European Union, as it may eventually boost the progress of research on possible applications in the field of molecular electronics.",Theoretical study of electronic transport in carbon nanostructures and molecular wires,FP7,08 July 2012,09 January 2008,161792.99 NANOTRANSDUCER,Sabanci University * Sabancı Üniversitesi,photonics,"Nano-optics is a rapidly growing field with potential uses in many practical applications. Near-field optical techniques that enhance localized surface plasmons are potential candidates for obtaining intense optical spots beyond the diffraction limit for various practical applications. Nano-optical transducers can be utilized in a traditional optical system to obtain spots beyond the diffraction limit. This system has a number of disadvantages for potential use in consumer electronic markets due to its large body mass, size, price, and difficulties in mass production. A thin film waveguide with planar optical lenses and mirrors having a nano-optical transducer around the focus can address these problems. In this work electromagnetic and thermal modeling and design tools will be developed to investigate this device. A volume integral equation based solution will be used for the solution of Maxwell's equation, and a finite element method based solution will be used for the solution of heat transfer equation. Designs will be identified to obtain small optical spots beyond the diffraction limit. Designs will also be optimized to obtain high transmission efficiency, which is necessary for practical applications such as data storage. The heating of the designs will be investigated.",Modeling and Design of Thin Film Waveguides Terminated with Nano-optical Transducers,FP7,30 June 2012,01 July 2008,100000.0 NANOTRIGGER,Center for Neuroscience and Cell Biology * Centro de Neurociências e Biologia Celular,health,"The advent of molecular reprogramming and the associated opportunities for personalised and therapeutic medicine requires the development of novel systems for on-demand delivery of reprogramming factors into cells in order to modulate their activity/identity. Such triggerable systems should allow precise control of the timing, duration, magnitude and spatial release of the reprogramming factors. Furthermore, the system should allow this control even in vivo, using non-invasive means. The present project aims at developing triggerable systems able to release efficiently reprogramming factors on demand. The potential of this technology will be tested in two settings: (i) in the reprogramming of somatic cells in vitro, and (ii) in the improvement of hematopoietic stem cell engraftment in vivo, at the bone marrow. The proposed research involves a team formed by engineers, chemists, biologists and is highly multidisciplinary in nature encompassing elements of engineering, chemistry, system biology, stem cell technology and nanomedicine.",Triggerable nanomaterials to modulate cell activity,FP7,31 October 2017,01 November 2012,1699320.0 NANOTRYP,Flemish Institute of Biotechnology * Vlaams Instituut voor Biotechnologie (VIB),health,"African trypanosomiasis is in need of new diagnostic detection tools and new treatment methods. To date the widely used card agglutination test for trypanosomiasis is not very specific as the test is based on the screening for cross-reactive host antibodies. The availability of treatment for Trypanosmiasis on the other hand is limited due to the fact that only very few drugs are registered for use, and all can cause serious side effects in treated patients or animals. Hence, this project will focus on the development of new and innovative diagnosis and treatment tools, using the nanobody technology that has been developed by the coordinating partner of this network. Nanobodies are small single domain antibody fragments that have unique properties that include their capacity to recognize particular epitopes (not recognized by conventional antibodies) and their improved stability. In addition, they can be used as molecular target- or transport devices of other biological active components. As such they are excellent tools to support this project. Despite the fact that the coordinating laboratory has been a pioneer in differential molecular characterization of African trypanosomes and were involved in the initial release of diagnostic PCR methods that have now been adopted by many other research groups, this project will deliberately adopt a different approach. Indeed, in comparison to nanobody technology, PCR based diagnostics are much more costly and require an infrastructure that is hard to sustain over prolonged periods of time in African 'field situations'. The simplicity of the nanobody technology on the other hand makes it an excellent topic for knowledge transfer. Despite it's high-technology approach, the technique it will be relatively easy to be adopted by laboratories of participating African partner groups.",Exploiting Nanobodies in development of new diagnostic tools and treatment methods for Trypanosomiasis.,FP7,30 June 2013,01 January 2009,2714608.0 NANOTUBE ENERGY,Bar-Ilan University,energy,"Efficient capture, storage, and controlled release of energy are major global challenges for the twenty-first century. Dramatic improvement in the performance of energy storage & conversion devices is needed to meet future energy demands of our society, mainly in electrical propulsion (full electric vehicle) and to overcome the inevitable future shortage in fossil fuels, especially in gasoline. By combining Professor Aurbach (Bar Ilan University) expertise of electrochemistry, especially of Li and Mg, with Dr. Gilbert Nessim (MIT) capabilities in synthesizing dense arrays of crystalline carbon nanotubes (CNTs) on metallic layers, we propose to investigate the development of more efficient batteries that use composite metal-CNTs as electrodes. The main novelty of our approach is to use functionalized carbon structures on various nanotube electrode materials to improve ion insertion and storage, safety, and performance of Li ion based batteries in ionic liquid and in electrolyte solution with wide electrochemical window. The technical plan includes the investigation of multiple electrode materials and geometries upon which CNTs will be grown and functionalized to optimize electrode performance and cycling. Additional aspects of this project include applying the techniques and materials developed to lead acid batteries and to design more efficient supercapacitors. Extensive collaboration with MIT and with other academic and industrial institutions in Europe and the USA is a key aspect of this multi-disciplinary project. The goal of the project is to reintegrate Dr. Nessim at Bar Ilan as a faculty in the department of chemistry.",Carbon nanotube structures as innovative electrode materials for more efficient energy storage devices,FP7,31 March 2014,01 April 2010,100000.0 NANOTUBEMEM,National Centre of Scientific Research Demokritos Institute of Microelectronics,environment,"Recently, carbon nanotube membranes attracted attention because of experiments and simulations indicating extremely high fluxes. If selective separations can also be demonstrated, these membranes will be a major breakthrough in efficient gas, liquid and vapor separations with tremendous implications in energy efficiency, especially in hydrocarbon separations, water purification and microdevices for hydrogen purification and storage. The currently used multi-step microfabrication procedures, although appropriate for laboratory scale measurements, do not allow for efficient and economic production of the large membrane areas (e.g., hundred square meters) needed for membrane based purification applications nor they provide means for precisely controlling nanotube size and structure that may be desirable for highly selective separations. We propose to undertake the challenge to develop practical selective nanotube membranes by growing submicron thick, densely-packed, subnanometer diameter carbon nanotubes in the interior of the pores of oriented aluminophoshate (AlPO4) molecular sieve films. The proposed use of AlPO4 films as hosts of carbon nanotubes is motivated by previous studies that demonstrate carbon nanotube synthesis inside the micropores of AlPO4 crystalline powders and builds on our ability to grow well-intergrown and appropriately oriented AlPO4 films. If successful, we expect to form high concentration of oriented and uniformly sized carbon nanotubes extending throughout the molecular sieve channels. It is possible that membranes with unprecedented performance (high selectivity and extremely high flux) will be the ultimate outcome of this work. Moreover, the growth technique that we propose to develop and the resulting oriented carbon nanotube films may be of interest for electronic and electrochemical applications.",Carbon NANOTUBE MEMbranes by Templated Growth in Oriented Molecular Sieve Films,FP7,10 July 2014,11 January 2008,100000.0 NANOTUBEQUBIT,University of Oxford,information and communications technology,"I will create a two-qubit universal quantum computer based on electron spins a carbon nanotube. Nanotubes are outstanding host material for spin qubits, because they allow hyperfine decoherence to be completely eliminated. Very recently, I demonstrated the first single qubit in a nanotube, using electric fields combined with a bend in the nanotube to coherently control an electron's spin. This project will realize the additional elements for a computer: high-fidelity qubit readout, a two-qubit gate, and long-lived quantum memory.",A quantum computer based on electron spins in carbon nanomaterials,FP7,03 July 2019,04 January 2013,0.0 NANOTUNE,Johnson Matthey Plc,health,"The IIF project NANOTUNE aims to design novel palladium nanoparticle-based catalysts with tuned particle properties, and use them to control the selectivity of catalytic reactions. Changes to the support and addition of second metals will be used to tune the electronic properties of the nanoparticles. In addition, the particle shape will be varied using templating species such as organic ligands or changing the porosity of the support. By a combination of these techniques, it will be possible to design a catalyst to give high catalytic selectivity. The catalysts will be tested in the direct synthesis of hydrogen peroxide from hydrogen and oxygen, and chemoselective hydrogenation of substrates relevant to the fine chemicals and pharmaceutical industries. The reactions were selected on the basis of their relevance to the sustainability and economic development of Europe. A high-level understanding of the shape and surface chemistry of the nanocatalysts will be achieved by using advanced characterisation methods, including solid state NMR, X-ray synchotron techniques, high resolution TEM and Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). Work in these areas will be in collaboration with the academic sector, both in the UK and Europe. The Fellow, Dr. Elena Cristina Corbos, is currently working in Japan, and will move to the UK and bring knowledge of the preparation of modified supports and DRIFTS catalyst analysis to the EU and to the host. The project has the potential to impact significantly on the future economic and sustainable development of the EU. Synthesis of catalysts with controlled properties is in line with the vision of the knowledge economy, which is a key part of the EU's future prosperity. Increased selectivity of catalytic reactions will improve sustainability, with fewer raw materials and energy required for the same yield of product.",Sustainable routes to shaped nanoparticles for selective catalysis,FP7,16 May 2012,17 May 2010,173240.0 NANOULOP,Technical University of Munich * Technische Universität München,photonics,"We propose to fabricate nano-patterned electronic circuits to demonstrate the control of the electronic motion by ultrafast photonic tools. Nanowires and nanosheets will play an important role to build the nano-architecture which allows the direct measurement of the photo current induced by intense, near single-cycle light fields with stable well-defined waveforms. Much attention will be focused on gallium nitride nanowires and titanate nanosheets due to their unique optical and electrical properties and their potential for applications in nanoelectronics. The growth of gallium nitride will be carried out by molecular beam epitaxy. Titanate nanosheets which are wide band gap semiconductor single crystals will be synthesized by exfoliation of layered titanate oxides. Furthermore, assemblies of multilayer films in which the nanosheets are used as building blocks will be fabricated via the layer by layer method. The nanomaterials will be used as bridges between two gold electrodes to build the nano-architectures for attosecond measurements. A valence band electron in a wide band gap solid can find itself promoted by an intense optical field into the conduction band, either by direct photon absorption, multi photon absorption or adiabatic interband tunneling. A second synchronized near single-cycle near-infrared field with well defined waveform will induce an electron momentum asymmetry resulting in a measurable electric current which can be controlled by waveform of the laser pulse. Such operation would enable the detailed understanding of the charge transport processes in direct time-domain, such as dephasing and electron scattering, in low dimensional systems. This project would help not only to demonstrate light-field control of electron motion in low- dimensional systems but also to develop ultrafast electronic technologies like logic circuits performing at optical frequencies in low-dimensional materials.",Nano-Architectures for Ultrafast Optoelectronics,FP7,31 August 2014,01 September 2012,174475.0 NANOVALID,NordMiljö O. Grahn AB,environment,"The growing development, production and use of engineered nanomaterials and associated products will increase exposure of both humans and ecosystems to these new materials. However, current knowledge is still incomplete and established test methods are as yet inappropriate to reliably assess the extent of exposure and risk of materials at the nano-scale. There is an urgent need to develop methods to overcome the current limitations of existing hazard and risk assessment schemes and to generate the body of reference data needed as the basis for regulative requirements and for measures to safeguard production, application and the disposal of nanomaterials.","Development of reference methods for hazard identification, risk assessment and LCA of engineered nanomaterials",FP7,10 July 2017,11 January 2011,0.0 NANOWAYS,Bertin Technologies SAS,health,"NANOWAYS will identify the software ICT milestones for the take-up of Micro/Nano applications in biotechnology, life sciences and food safety. The roadmap will: - Map ICT issues affecting the deployment of Nano/Micro-Bio systems - Detail a short-term (5 years) roadmap to advance the most mature systems to deployment levels - Describe a mid-term (10-15 years) roadmap for disruptive ICT research in Nano/Micro-Bio integration. NANOWAYS addresses applications requiring strong integration across biology, ICT, micro/nano technologies: Integrated Micro devices and Integrated Nano Systems. Applications feature systems such as wearable and implantable devices, biochips, drug delivery devices, micro-robotic systems. NANOWAYS meets the IST Integrated Micro/Nano Subsystem Strategic Objective. The project will build on several IST projects addressing micro/nano technologies, especially the federative project NEXUSPLUS. This roadmap will complement the NMP planning activities, especially hardware roadmaps NANOROADMAP and NANO2LIFE. NANOWAYS will propose orientations for technology organization, innovative educational support, policy levers to facilitate the roadmap execution. Prominent Technology organizations participate in the consortium: The Frauhnofer Institute, CEA, VTT. They bring solid industry connections established through dedicated tools such as Excellence Poles, bilateral collaborations. Philips Medical Systems is to join the consortium and will strengthen the industry vision. Bertin Technologies and Cambridge Consultants Ltd will articulate the activity. The work plan relies on strong industry involvement in work groups to achieve a consensus on the technology and application vision. Dissemination is key to ensure that the roadmap will reach actors beyond the consortium. The project will maintain close connections with other relevant IST and NMP projects and will interact with significant national and European technology convergence initiatives.",A roadmap for software ICT-enabled Micro/Nano-Biotechnology Applications,FP6,29 February 2008,29 August 2006,348366.0 NANOWEB,Bilkent University * Bilkent Üniversitesi,health,"Electrospinning is a technique for producing nanofibers by creating a continuous filament by exposing a polymer solution or polymer melt to very high electrical fields. Due to its versatility and cost effectiveness, electrospinning has gained wide use recently to produce functional nanofibers from different materials, which include polymers, polymer blends, ceramics, sol-gels and composite solutions. Electrospun nanofibers and their nanowebs have several remarkable characteristics such as very large surface-to-volume ratio, pore sizes in nano range, unique physical properties along with the design flexibility for chemical/physical functionalization by incorporating specific additives into nanofibers. The unique properties and specific functionalities of such nanofibers/nanowebs make them favorable candidates in many applications areas such as medical/biotechnology, filtration and membrane technology, functional textiles, sensors, energy, composite materials, etc. Nanofibers/nanowebs from various types of natural and synthetic polymers can be easily produced by electrospinning, yet, improvements and new functionalities are always desired in order to enhance the properties of these electrospun nanofibers/nanowebs and broaden their application areas. Herein, it is proposed to fabricate functional polymeric nanofibers/nanowebs containing specific additives (cyclodextrins, textile additives, antibacterials, etc) by using electrospinning technique. The aim of this project is to produce new functional electrospun nanofibers/nanowebs and investigate their properties for the development of multi-functional nanofibrous materials for applications in filtration, functional textiles, medical/biotechnology, etc. The research proposed here has an interdisciplinary nature in the field of chemistry, materials science, textile, biology and engineering.",Development of Functional Nanofibers by Electrospinning,FP7,30 April 2014,01 May 2010,100000.0 NANOWIREDEVICESTM,Lund University * Lunds Universitet,energy,"Free-standing III-V semiconductor nanowires, with diameters of about 20 to 80 nm at a length of several µm, offer tremendous possibilities for application in photovoltaics, optoelectronics, information technology as well as life-science. Semiconductor nanowire devices are not only smaller than conventional structures and significantly power-saving, but can even exhibit qualitatively novel behavior. Due to the small size and the very large surface to bulk ratio, the nanowire surface has a crucial influence on the performance of the entire device. Up to now, the conductivity and other electric properties of single nanowire devices on one hand and the nanowire crystal and surface structure on the other hand could only be measured separately. Here, we will combine both approaches in a novel experimental setup, enabling us to achieve information on the atomic surface structure and local electronic properties of an individual nanowire as well as the global electric behavior of a device built by the same nanowire simultaneously. For this purpose, we will study single, individually contacted semiconductor nanowires using scanning tunneling microscopy and spectroscopy (STM), obtaining data on e.g. the chemical composition and atomic reconstruction of the nanowire surface as well as the local density of states and local variations of the band alignment. During these STM measurements, external source, drain and gate voltages can be applied to the nanowire device, revealing the complex interaction of the nanowire surface, local charge distribution, and global device performance like conductivity and other transport properties.",Combined structural and electronic characterization of semiconductor nanowire devices on the atomic scale using scanning tunneling microscopy and spectroscopy,FP7,31 December 2012,01 January 2011,179169.0 NANOWIRES,Istanbul Sehir University * İstanbul Şehir Üniversitesi,health,"Research and development in nanotechnology has seen an astonishing progress during the past decade, and has now provided clearer indication of its potential. There is great potential to incorporate nanotechnology-enabled products and services into almost all industrial sectors and medical fields by 2020. Resulting benefits will include increased productivity, more sustainable development, and new jobs. To advance our scientific knowledge, and to bring competitive advantage to the EU research and development in nanotechnology, PI proposes to investigate silicon carbide (SiC) and aluminum nitride (AlN) wide-bandgap semiconductor nanostructures and develop new applications of these nanostructures for energy generation, optoelectronics, and sensing. The proposed project is aimed not only to address the fundamental technical and scientific issues of 1D nanostructures, but also develop original products utilizing these materials. 1D-AlN nanostructures are extremely important for many applications in several fields including power transistors, optoelectronics, heat sinks, resonators, sensors, and nanogenerators. Similarly, due to its inherent superior properties, SiC is an excellent material for applications in many areas including microelectronics (high temperature, high power, and high frequency), thermoelectrics, optoelectronics, and biomedical. The specific research objectives are: 1) Full spectrum characterization of AlN nanostructures; 2) Development of AlN nanostructure based electricity generators (nanogenerators); 3) Full spectrum characterization of SiC nanowires; 4) Fabrication of SiC-nanowire devices for studying electrical, photoconductivity, and thermoelectric properties of the SiC nanowires. The proposed project will significantly contribute to Europe's competitiveness in nanotechnology, since the project greatly overlaps with the EU-Horizon -2020's specific objective and broad lines of activities for nanotechnology research, development, and education.",One-Dimensional Wide-Bandgap Semiconductor Nanostructures: Analysis and Applications,FP7,31 March 2017,01 April 2013,100000.0 NANOWIRING,Georg August University of Göttingen * Georg-August-Universität Göttingen,photonics,"The interest in bottom-up fabricated semiconductor nanowires (NWs) has been growing steadily in the last years due to their potential as basic building blocks of nanoscale devices and circuits. Investigations performed so far try to exploit three unique properties of NWs: First, they are the smallest dimension structures that allow optical guiding and electrical contacting simultaneously. Second, their large surface to volume ratio enhances their interaction with the environment, turning them into optimal chemical and biological sensors. Finally, their anisotropic geometry makes their optical and electrical properties dramatically dependent on their orientation, allowing their use as polarization-dependent sensors. Most NW applications rely on the ability to grow, characterize (structurally, optically and electronically) and manipulate both individual and collections of NWs. To date it is rather difficult to find a single research group covering all of the above competences, and students (or post-docs) usually focus on a single aspect of NW-based device realization (either growth, characterization, simulation or device assembly). The scope of this project is to create a European Network of experienced teams that will provide early stage researchers with a multidisciplinary framework and a comprehensive training in the field of NW physics and applications. The active involvement of industrial partners will ensure that the acquired competences are driven by industrial needs, such as scalable and low cost NW production. The interaction with associated industrial partners will also add to the employability of the recruited researchers through the exposure to the private sector. The main applications that we intend to address within the project time are the following: (i) nanowires for sensing applications, (ii) nanowires for optoelectronics (iii) nanowires for nanoelectronics and (iv) nanowires for energy harvesting.",Semiconductor nanowires: from fundamental physics to device applications,FP7,31 October 2014,01 November 2010,4716261.0 NANOXIDE,National Research Council * Consiglio Nazionale delle Ricerche (CNR),photonics,"The Nanoxide project aims to investigate, control and exploit the properties of interfaces between isostructural functional oxides for the realization of new nanosized electronic and optoelectronic devices. The project will study interfaces between transition metal oxides with perovskite type structure. Most perovskite oxides are correlated electronic systems which offer a rich spectrum of physical properties such as superconductivity, ferromagnetism, ferroelectricity, semiconducting or metallic behaviour. Such properties are present in compounds with the same crystal structure, allowing the engineering of new epitaxial multifunctional devices. Interfaces in such highly correlated systems are very complex due to the collective nature of electronic behaviour and offer new application possibilities with respect to conventional semiconductors. The project will be focused on selected interfaces in bilayers and heterostructures made of oxides with different functional properties, such as dielectric and superconductors, magnetic and metallic oxides. Interfaces will be realized by epitaxial thin films deposition in state-of-the-art systems that permit to control of the growth at atomic level. The structural, chemical and physical properties of such interfaces will be characterized and modelled. The functional properties of interfaces originating by the proximity of layers with different physical properties will be thoroughly studied. Charge and spin transport across the interfaces as well as induction of charge and strain near the interfaces will be investigated in details. Deliverables of the project will be strain gated and a field effect device whose performances can be tuned by tailoring interfaces as actual realization of selected demonstrators, and, furthermore, advances in knowledge and control of oxide interfaces properties. Nanoscale reduction of these devices will be addressed to open the way to novel technological outcomes.",Novel Nanoscale Devices based on functional Oxide Interfaces,FP6,31 August 2009,01 September 2006,2971997.0 NAOMITEC,Italian Association for Industrial Research * Associazione Italiana per la Ricerca Industriale (AIRI),transport,"The primary objective of the present proposal is to promote the participation of SMEs in the new instruments of FP6: IPs, in particular, and NoE. The attention will focus on projects referring to nano and micro technologies and their application in the most important industrial sectors (ITC, Transportation, Health Care, Aerospace and Environment) which happen to be also among the priority themes of FP6. Given the high impact of these technologies on the future technological innovation they both are high in the agenda of FP6. Nanotechnology is the principal objective of the Thematic Priority Area 3,but micro and nano technology will be fundamental drivers of the research also in practically all the other thematic priorities. IPs and NoE are the instruments of choice in FP6 to foster research and technological innovation in Europe. By promoting the participation of SMEs in IPs and NoE,this project aims to make sure that SMEs will participate to this effort. To reach this goal the activity will aim to: o Assess situation and perspectives in the countries participating in the project with respect to micro and nanotechnologies and the five sectors of application selected to pin point SMES,research structures and facilities,technological incubators,large enterprises,etc. o Identify the SMEs that are most active and qualified. Assess their needs and plans. o Identify IPs and NoE that fit with needs and plans of SMEs. o Establish contacts that could be instrumental for the creation of national and trans-national networks,make evident synergies between projects. o Assist the SMEs to join the above said projects assuring the quality level of this participation. The project brings together partners from 13 countries,some are NAS and 2 are from outside the ED,giving to it a large trans-national,pan-European character. The objective is to assist",NAno and MIcro -TEC SMEs in Integrate Projects (IPs) and Networks of Excellence (NoE),FP6,31 December 2006,01 July 2004,1382405.42 NAPA,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,manufacturing,"The growing importance of nanotechnology for the European Research Area is reflected in the FP6 Thematic Priorities. It is foreseen that most of the projects submitted to the Priority Area 3 (NMP) will need and develop nanopatterning techniques in one way or another. The Emerging Nanopatterning Methods (NaPa) consortium integrates the new patterning methods into one project, both anticipating and responding to the increasing need for technologies, standards and metrology required to harness the new application-relevant properties of engineered structures with nm-scale features. The NaPa consortium complements the deep UV technology by providing low-cost scalable processes and tools to cover the needs of nanopatterning from CMOS back-end processes through photonics to biotechnology. To achieve this, research in three technology strands is proposed: nanoimprint lithography, soft lithography & self-assembly and MEMS-based nanopatterning. While the former is at a crucial embryonic stage, requiring prompt consolidation to yield its first products in one or two years, the other two will result in applications towards the end of the project. Research in three overarching themes required by all strands: Materials, Tools and Simulation will be undertaken. NaPa brings together 35 leading academic and industrial European institutions with a vast amount of recent know-how on nanofabrication, partly developed within FP5. In total, 3500 person months will be contributed by the partners to the project. Complementing R&D, the consortium will design exciting nanoscience and nanoengineering courses to advance the training of the next generation of scientists and engineers and to create a positive attitude towards science among young people. Dissemination activities towards the lay public and sectors underrepresented in nanotechnology form an integral part in NaPa. Thus, NaPa offers a unique opportunity to unleash the potentials of #",Emerging Nanopatterning Methods,FP6,29 February 2008,01 March 2004,1.5994871E7 NAPANIL,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,manufacturing,"The NaPANIL project aims to develop processes, materials and tools, both for manufacturing and for control, for truly 3-dimensional nanosurfaces with feature dimensions ranging from 50 nm to several ïm. The nanosurfaces will be realised using various variants of nanoimprinting lithography. The dedicated application is to control light at nanostructured surfaces and a few potential high impact products have been identified by the end-user partners in the consortium. Design, demonstration and prototyping these applications will act as test-bench for the new manufacturing paradigm. The manufacturing processes possess generic aspects for production of any kind of topographically 3-dimensional nanostructured surfaces. In the R&D of nanoimprinting Europe has a leading position. The NaPANIL consortium combines the best expertise and know how in field to reach the goals in the project.","Nanopatterning, Production and Applications based on Nanoimprinting Lithography",FP7,04 June 2014,05 January 2008,1.18E7 NAPEP,Baku State University,photonics,"The project focuses on creating a nanotechnology platform at Baku State University through cooperation with nanotechnology centers in EU countries which is important for the development of research in nanoelectronics and photonics in the collaborating countries. The project addresses the increasing cooperation capacity between NanoCenter Baku State Uiversity and EU research centers in the area of nanotechnology. Activities have been designed in close co-operation between the three participants: the applicant and the two European universities. Coordination actions in the project will cover activities such as meetings, workshops, seminars, exchanges of researchers, exchange and dissemination of experiences, management of initiatives and joint solving of current research problems. During project implementation good networking relationships and joint research plans will be formed. The partners will continuously evaluate and develop the dissemination activities, negotiating, sharing experiences on meetings and learning best practices from other similar projects. During the whole project the partners will ensure the interactivity and effective cooperation so as to guarantee the adaptation of innovative new results.",Nanotecnology platform for electronics and photonics,FP7,31 October 2013,01 November 2010,498322.0 NAPILIS,Research Center Fiat * Centro Recherche Fiat (CRF) SCPA,information and communications technology,"SelfLubricating Metal and Ceramic Matrix NanoComposites are materials consisting of a metal or hartstoff matrix with dispersed selflubricating nanoparticles. Fon Piston/Liner systems the matrix may be a refractory metal like tungsten, molybdenum and chromium or a carbide or nitride of these metals or titanium, etc. The solid lubricant would be graphite, fdisulfide, h-BN, etc. SLMCMNCs have so far never been synthesized and there exists no process technology for their synthesis. Selflubricating nanocomposites with a lubricant matrix (DLC) and carbide (WC, B4C) inclusions are state of the art since 15 years. They are produced by a P&CVD method on a large scale. Selflubricating Metal and Ceramic Matrix MicroComposites are state of the art since at least a century. They are produced by filling (SiC/C), sintering and casting (e.g. grey cast iron, Pb/PTFE, CuSnPb, AlSn, etc) , galvanic & electroless deposition (Ni/PFE), plasma spraying (alloy + MoS2, PTFE). They are used for gliding seals. The technologies used for selflubricating microcomp.can not be used for nanocomp. for worker's hygiene reasons, since they would involve handling of large quantities of powders of nanosized particles, which are a clear health risk. The state of the art PVD or CVD methods have failed so far in producing such nanocomp. (with the exception of AISn20), since these technologies usually do not produce bi-phase materials.In NAPILIS project two solutions will be explored: 1.sputter deposition process, combining the selection of an appropriate metallurgy with the use of extremely short (msec) intense heat spikes to promote the appropriate segregation. 2. in a combined arc+ sputter process, strong nano-particle emission from a graphite source will be obtained. SLMCMNCs will be then applied to Piston/Liner systems with the objective to have an high performance sealing giving an important contribution to clean and resource efficient IC engines.'",Nanocomposites for Piston/Liner Systems,FP6,30 November 2007,01 March 2004,1180006.0 NAPOLI,Technische Universiteit Eindhoven * Eindhoven University of Technology,photonics,"In today's ware house sized computers the interconnection of individual processing cores is limiting the total system performance. Interconnects already take up about 50% of the systems power consumption and this value increases with system complexity. Optical interconnects are nowadays employed for rack-to-rack communication to overcome this 'interconnect bottleneck' by reducing space requirements and power consumption. In the future, such optical technologies must penetrate deeper in the system design and be applied for chip-to-chip, or even on-chip interconnection to sustain the exponential growth of computer performance. New approaches are needed to meet the extreme requirements in integration density, power consumption and cost for optical interconnects in future high performance computers. By exploring the limits of miniaturization and energy efficiency in integrated active optical components we want to demonstrate a compact optical link and assess the potential of nanophotonic technology for integrated optical chip-to-chip or even on-chip interconnects. We will employ metallo-dielectric cavities to shrink the footprint of devices, which in turn will increase operation speed, reduce power consumption and allow efficient cooling of the highly integrated devices through the metal surfaces. We will develop a first waveguide coupled nanolaser, demonstrate optical detectors with record small footprint and demonstrate for the first time an optical interconnect that satisfies the requirements of future computing systems with respect to transmission density, power consumption and device size. The acquired techniques will directly contribute to the development of a photonic technology platform. Such innovations in photonic technology are essential to overcome the interconnect bottleneck and enable next generation computing technology.",Nano Photonic Optical Link,FP7,31 July 2016,01 September 2013,72916.0 NAPS,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,manufacturing,"The general goal of this project is to train young researchers in nanotechnology, to go for a technology leap from purely silicon technology to new and more advanced technologies in the future Europe. A broad interdisciplinary training program in the field of nanotechnology is proposed covering three areas, 1) The improvement of analysis methods for nanotechnology, 2) prototyping of nano-devices and 3) a novel and future process for nanotechnology, i.e., self-assembly. The objectives of the training program are:O1: Challenge the limits of high-resolution imaging and explore new types of electron sources. O2: Perform research on new ways to image and understand self-assembly processes.O3: Investigate ways to enhance electron beam lithography and nano-deposition techniques.O4: Research on a new ion source that can produce focused ion beams of any desired atom.O5: Build sensors for bio-molecules from nanotubes and nanowires, using self-assembly and micro-contact printing.O6: Build sensors for bio-molecules using self-assembly of magnetic particles. It is expected that the proposed training will meet the stringent needs of a modern science and technology training, which will give the trainees a strong basis to start a research career at international top-level. The training will be in Philips Research Labs in Eindhoven, The Netherlands, mounted in the sector Materials and Process Technology. This sector, where all activities of Philips Research on basic physics, chemistry and nano-technology are concentrated, consists of a staff of 130 highly skilled researchers. The program is embedded in a large structure of successful Philips internal projects related to nanotechnology and a network of national- and international contacts with university groups. The requested 6 trainees will be coached by 10 senior-, or principal scientists at Philips Research and by 6 professors from 4 Dutch universities (Delft, Eindhoven, Leiden and Utrecht).","Nano-Scale Analysis, Prototyping and Self-Assembly Processes",FP6,28 February 2009,01 March 2005,1004354.0 NAQUOP,Technische Universiteit Delft * Delft University of Technology,photonics,"We propose developing a nanodevice toolbox for single photon quantum optics. A scalable scheme to generate indistinguishable single photons, an interface to couple single photon polarization to a single electron spin and high efficiency single photon detectors represent the core of the scientific problems to be addressed in this project. We set the following research objectives: 1- Understand to what extent quantum dots can be made indistinguishable. 2- Interface coherently single photons to single electron spins via strain engineering in quantum dots. 3- Gain a better understanding of the limits to time resolution and detection efficiency of ultrafast superconducting single photon detectors. The proposed research effort will yield novel experiments: the realization of scalable indistinguishable quantum dot sources by frequency locking single quantum dots to atomic transitions, the demonstration of new selection rules in semiconductor nanostructures to couple photon polarization to the electron spin only, the development of ultrafast and high efficiency single photon and single plasmon detectors and their implementation in two photon interference and quantum plasmonics experiments. To carry out the work, multidisciplinary efforts where nanofabrication, quantum optics, semiconductor and superconductor physics will be merged to demonstrate the scalability of quantum dots for quantum information processing, providing crucial new knowledge in single photon optics at the nanoscale. The impact of the project will be important and far reaching as it will address fundamental questions related to the scalability of quantum indistinguishability of remote nanostructures.",Nanodevices for Quantum Optics,FP7,31 March 2018,01 April 2013,1500000.0 NARCISUS,BioInfoBank Institute,health,"Beside these well-known molecules there is a vast unknown world of tiny RNAs (RiboNucleic Acids) that might play a crucial role in a number of cellular processes. Those elements are named noncoding RNAs (ncRNA) and they play their function without transcription to the protein product. Here is proposed development of integrated bioinformatics platform that is specifically addressed for detecting, verifying, and classifying of noncoding RNAs. This complex approach to "Computational RNomics" will provide the pipeline which will be capable of detecting RNA motifs with low sequence conservation. It will also integrate RNA motif prediction which should significantly improve the quality of the RNA homolog search. The first commercial application is the integrated system for detection of new regulatory elements located in the non coding genome parts. Up to now numerous human disorders have been found to be related to some of the noncoding RNA's The second application of the project is so called RNA nanotechnology. It is designing of artificial nanoparticles, which are assembled mainly from ribonucleic acid which possess both the right size and ability to gain entry into cells and halt viral growth or cancer's progress or deliver drugs. The project will benefit from latest achievements in High Performance Computing and General-Purpose computing on Graphics Processing Units and Graph theory.",Noncoding RNA Comparative Searching System,FP7,31 October 2012,01 November 2010,30000.0 NAREB,Pasteur Institute * Institut Pasteur,health,"Increase in antibiotic resistance is a global concern worldwide. The project NAREB's main objective is the optimization of several nanoformulations of antibacterial therapeutics in order to improve the therapy of multi-drug resistant (MDR) tuberculosis (TB) and MRSA infections in European MDR patients. NAREB will address the problem of drug bioavailability inside the infected macrophages, transport across the bacterial cell wall, and avoidance of escape mechanisms (expressed by the pathogen). The success of the utilization of nanoparticles in the improvement of drug targeting in other diseases opens the way for novel applications in nanotechnology-based treatments aimed at controlling MDR-TB and MRSA. Specific objectives to achieve the main goal are: (i) Screening of different combinations of antibiotic drugs (small chemical molecules and/or biomacromolecules - glycopeptides) with nanocarriers (lipid, polymeric, biopolymeric); (ii) Loading of Transcription Factor Decoys (TFDs) designed to block the expression of essential bacterial genes in compatible nanoparticle systems and their testing as novel antibacterials; (iii) In vitro and in vivo testing of the best therapeutic combinations in relevant experimental models and using innovative bioimaging; (iv) Improved formulations of multifunctional particles containing selected antibiotics and TFDs for increasing the bioavailability of active molecules in the site of infection (targeting strategy, adapted route of administration) (v) Assessing safety, regulatory and production (GLP/GMP) aspects in relation with the most promising nanoformulations; (vi) Clinical Development Plan for the preparatory work for the subsequent clinical testing of the selected nanoformulations. The project NAREB brings together 15 partners (including 4 SMEs and 1 industry) from 8 EU Member and Associated States with outstanding complementary expertise, ranging from material engineering to molecular biology, pharmacology and medicine.",Nanotherapeutics for antibiotic resistant emerging bacterial pathogens,FP7,31 January 2018,01 February 2014,9674158.0 NARESCO,Ghent University * Universiteit Gent,photonics,"In this project we will develop nanophotonic reservoir computing as a novel paradigm for massively parallel information processing. Reservoir computing is a recently proposed methodology from the field of machine learning and neural networks which has been used successfully in several pattern classification problems, like speech and image recognition. However, it has so far mainly been used in a software implementation which limits its speed and power efficiency. Photonics could provide an excellent platform for such a hardware implementation, because of the presence of unique non-linear dynamics in photonics components due to the interplay of photons and electrons, and because light also has a phase in addition to an amplitude, which provides for an important additional degree of freedom as opposed to a purely electronic hardware implementation. Our aim is to bring together a multidisciplinary team of specialists in photonics and machine learning to make this vision of massively parallel information processing using nanophotonics a reality. We will achieve these aims by constructing a set of prototypes of ever increasing complexity which will be able to tackle ever more complex tasks. There is clear potential for these techniques to perform information processing that is beyond the limit of today's conventional computing processing power: high-throughput massively parallel classification problems, like e.g. processing radar data for road safety, or real time analysis of the data streams generated by the Large Hadron Collider.",Novel paradigms for massively parallel nanophotonic information processing,FP7,31 December 2015,01 January 2010,1260000.0 NAS-ERA,Development Centre of Advanced Technologies * Centre de Développement des Technologies Avancées,energy,"The overall aim of the NaS-ERA project is to integrate the Unité de Développement de la Technologie du Silicium (UDTS) into the European Research Area (ERA), by developing cooperation with European research and innovation organisations in its 3 strongest research topics: i) Production of functional nanostructures, ii) Development of new detection methods, and iii) Design and development of new sensors. UDTS is a major R&D entity under the Ministry of Higher Education and Scientific Research of Algeria with a high potential for integration into ERA. Since its establishment in 1988, UDTS' main mission was to conduct scientific research activities and technological innovation in silicon material and semiconductor science and technology: photovoltaic, functional nanostructures, measurement and detection systems, optoelectronics, photonics, etc. In 2010, UDTS has evolved into a National Research Centre and is planned to set up, with the support of local universities and research entities, a technology Cluster in material science with a sufficient research capabilities to reach International norms and standards. The NaS-ERA project will build upon UDTS's existing strengths as a high-quality research institution via capacity building activities with the following 4 excellent European research and innovation organisations: 1) CNRS -Laboratoire de Physique de la Matière Condensée, 2) National Institute of Metrological Research, 3) Fraunhofer Institute for Mechanics of Materials, and 4) Intelligentsia Consultants. The capacity building activities will involve twinning and training development for UDTS researchers focused on the Production of functional nanostructures, the Development of new detection methods, the Design and development of new sensors, and the FP7 programme. Also, it will involve dissemination and strategy development to support the UDTS organisation.",Reinforcing Nanostructured material research cooperation between the Unité de Développement de la Technologie du Silicium (UDTS) and the European Research Area (ERA),FP7,30 September 2014,01 October 2011,498394.0 NAS-SAP,Royal Holloway and Bedford New College,health,"In contrast to 'top down' fabrication, biology makes low cost replicable and precise nanosystems using 'bottom up' self assembly. We propose to develop a platform self assembling nanoarray system using proteins from 2 microbial structures: SPORE COATS and S-LAYERS. SPORE COATS form the protective shell of bacterial endospores, S-LAYERS the surface layer of most bacteria. Both have protective properties and consist of self-assembled protomers forming extremely uniform paracrystalline surfaces with hexagonal, square or oblique patterns and unit distances of several nanometres. The surfaces can be homogeneous or heterogeneous can impose nanostructure on to other elements. There are 9 research partners from 6 EU plus 1 ACC state. Two partners are SMEs with established interests in nanobiotechnologies for industry who will exploit commercial opportunities from this 3 year research program. It has a strong set of partners with worldwide expertise in S-layers, bacterial spores, nanoimaging, protein engineering and structure analysis, plus strong management from an SME. The longterm objectives are to develop methodologies and IP for exploitation of bacterial surface structures and components for nanoengineering. This fits well with the guidelines for STREP activities. We propose to: *Dissect and understand the processes that build bacterial Spore Coats and S-Layers *Optimise for self assembly on planar, 3D and particle surfaces with several array geometries *Develop homogeneous and heterogeneous nanoarrays *Develop and understand techniques needed to couple arrays to organic and inorganic components supporting application development *Build a portfolio of IP covering the core platform, its coupling to effectors and its use, by developing prototype applications-biocatalysis, biosensors, immunogens, drug delivery and metallic nanoarrays",Nano Arrayed Systems based on Self Assembling Proteins,FP6,30 September 2008,01 April 2005,2299703.0 NASA-OTM,Juelich Research Centre * Forschungszentrum Jülich,manufacturing,"The main objective of the proposed project is the development and industry-driven evaluation of highly stable and highly oxygen-permeable nano-structured oxygen transport membrane (OTM) assemblies with infinite selectivity for oxygen separation from air. The new approach proposed to reach this objective is the development of ultra thin membrane layers by e.g. CVD, PVD or Sol-Gel techniques with catalytic activation of the surfaces. This approach is supposed to make available highly stable membrane materials, which are currently out of discussion as the oxygen permeation measured on thick membranes is too low. Sufficiently high oxygen fluxes shall be obtained by (i) ultra thin membrane layers on porous supports to minimize diffusion barriers; (ii) catalytic surface activation to overcome slow surface exchange/reaction kinetics; and (iii) thin-film nano-structuring, generating new diffusion paths through the grain boundaries in a nano-crystalline matrix. The membrane development is supported by thermo-mechanical modelling as well as atomistic modelling of transport properties. The produced oxygen is provided to Oxyfuel power plants or chemical processes such as oxidative coupling of methane (OCM) to higher hydrocarbons or HCN synthesis, which will contribute in a way to the mitigation of CO2 emissions. Oxyfuel power plants combust fuels using pure oxygen forming primarily CO2 and H2O making it much easier and cheaper to capture the CO2 than by using air. The major advantages of OTM are significantly lower efficiency losses than conventional technologies and the in principle infinite oxygen selectivity. OCM produces higher hydrocarbons directly without forming CO2 and HCN synthesis can be improved by process intensification resulting in energy and subsequent CO2 savings.",NAnostructured Surface Activated ultra-thin Oxygen Transport Membrane,FP7,08 July 2014,09 January 2009,3200363.0 NASCENCE,Universiteit Twente * Twente University,health,"The aim of this project is to model, understand and exploit the behaviour of evolving nanosystems (e.g. networks of nanoparticles, carbon nanotubes or films of graphene) with the long term goal to build information processing devices exploiting these architectures without reproducing individual components. With an interface to a conventional digital computer we will use computer controlled manipulation of physical systems to evolve them towards doing useful computation. During the project our target is to lay the technological and theoretical foundations for this new kind of information processing technology, inspired by the success of natural evolution and the advancement of nanotechnology, and the expectation that we soon reach the limits of miniaturisation in digital circuitry (Moore's Law). The mathematical modelling of the configuration of networks of nanoscale particles combined with the embodied realisation of such systems through computer controlled stochastic search can strengthen the theoretical foundations of the field while keeping a strong focus on their potential application in future devices. Members of the consortium have already demonstrated proof of principle by the evolution of liquid crystal computational processors for simple tasks, but these earlier studies have only scraped the surface of what such systems may be capable of achieving. With this project we want to develop alternative approaches for situations or problems that are challenging or impossible to solve with conventional methods and models of computation. Achieving our objectives fully would provide not only a major disruptive technology for the electronics industry but probably the foundations of the next industrial revolution. Overall, we consider that this is to be a highly adventurous, high risk project with an enormous potential impact on society and the quality of life in general, including medicine, everyday household items, energy-saving policies, security, and communication.",NAnoSCale Engineering for Novel Computation using Evolution (NASCENCE),FP7,31 October 2015,01 November 2012,2900000.0 NASCENT,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,energy,"The overall objective of the project is to develop new Nanomaterials with New Production Technologies and to fabricate silicon quantum dot tandem solar cells to achieve increased efficiencies. The understanding of electrical transport and recombination mechanisms in these newly developed nanomaterials will enable us to design new tandem solar cell structures - based on Si thin-film or wafer solar cells - that help to overcome the efficiency limits of these conventional concepts. In order to reach our goals, considerable R+D work has to be performed on semiconductor bulk materials, thin layers and hetero-structures for such solar cells. These topics have not yet or only in parts been investigated and are also of high scientific interest for novel photonic and charge storage devices incorporating Si nanocrystals embedded in Si alloys. The consortium of this project, also including two companies, merges the scientific and technological competences that are necessary to find answers to these questions. Another objective is the compatibility of the newly developed technologies with high-throughput processing to ensure further cost-reduction. The expected significant jump in the solar cell and processing evolution will lead to higher efficiencies for solar cells and to ongoing cost-reduction also with a long-term perspective and will help to strengthening the European leadership in PV technologies. Thus it will also have a positive impact on the acceptance of photovoltaics by the public and by politics. Moreover, since 'energy efficiency' is a big subject in the public discussion, photovoltaics will be an example of one of the highest electricity production efficiencies that have been achieved of all power generators. To sum up, we believe that this project will have a direct and positive impact on the European PV industry and its status in material science and it will contribute to the very ambitious goals of the EU commission in CO2 reduction in general.",SILICON NANODOTS FOR SOLAR CELL TANDEM,FP7,31 August 2013,01 September 2010,2982855.0 NASIMA,Universiteit Twente * Twente University,health,"Molecular scale interactions at artificial and naturally occurring responsive surfaces, e.g. the cell membrane, play a crucial role in many biological and biomedical processes. Responsive surfaces with molecular level control are considered as key to many crucial problems in nanobiotechnology. We aim at contributing to the development of such surfaces starting from a fundamental understanding of structure-property relationships in advanced nanomaterials and processes from the molecular scale. Specifically we propose to investigate the translation of external stimuli into forces in single macromolecules by means of atomic force microscopy (AFM) measurements for two classes of stimuli-responsive polymers, i.e. unique redox-active organometallic poly(ferrocenylsilanes) and elastin-based biopolymers. The communication with single molecules occurs via conformational/dimensional changes of these polymers under stress via changes in chain torsional potential energy landscape and thus variations in the corresponding macromolecular characteristic ratio. These occur upon redox stimulation or upon changes in e.g. temperature or pH. The challenging project will be tackled in a rational manner (control instead of trial and error) by depositing molecules individually at precisely defined positions using scanning probe lithography. Subsequently, the nanomechanical properties of an ensemble of individually addressable molecules will be probed molecule for molecule by single molecule force spectroscopy, hence avoiding a convolution of data of many molecules. This approach will also be utilized to selectively pick up individual macromolecules by chemically functionalized tips, followed by AFM measurements that aim at unraveling the effects of several external stimuli on the macromolecules response. Based on the results, responsive surfaces with molecular level control can be designed for applications in the areas of (bio)sensors, drug delivery, nano/microfluidics, and smart coatings.",Nanotechnology with Single Macromolecules,FP6,30 November 2006,01 December 2004,150977.0 NASIMA,Instituto de investigación en Ciencia y Tecnología de Materiales,health,"Molecular scale interactions at artificial and naturally occurring responsive surfaces, e.g. the cell membrane, play a crucial rolein many biological and biomedical processes. Responsive surfaces with molecular level control are considered as key to manycrucial problems in nanobiotechnology. We aim at contributing to the development of such surfaces starting from afundamental understanding of structure-property relationships in advanced nanomaterials and processes from the molecularscale. Specifically we propose to investigate the translation of external stimuli into forces in single macromolecules by meansof atomic force microscopy (AFM) measurements for two classes of stimuli-responsive polymers, i.e. unique redox-activeorganometallic poly(ferrocenylsilanes) and elastin-based biopolymers. The communication with single molecules occurs viaconformational/dimensional changes of these polymers under stress via changes in chain torsional potential energy landscapeand thus variations in the corresponding macromolecular characteristic ratio. These occur upon redox stimulation or uponchanges in e.g. temperature or pH. The challenging project will be tackled in a rational manner (control instead of trial anderror) by depositing molecules individually at precisely defined positions using scanning probe lithography. Subsequently, thenanomechanical properties of an ensemble of individually addressable molecules will be probed molecule for molecule bysingle molecule force spectroscopy, hence avoiding a convolution of data of many molecules. This approach will also beutilized to selectively pick up individual macromolecules by chemically functionalized tips, followed by AFM measurements thataim at unraveling the effects of several external stimuli on the macromolecules response. Based on the results, responsivesurfaces with molecular level control can be designed for applications in the areas of (bio)sensors, drug delivery,nano/microfluidics, and smart coatings.",Nanotechnology with Single Macromolecules,FP6,05 March 2006,06 March 2006,34900.62 NASLA,Polytechnic University of Turin * Politecnico di Torino,health,"The aim of this project is to provide four EU SMEs (Alce Calidad, EASReth, Di.Pro. and Aero Sekur) with a new silver/silica based coating material having anti-septical properties superior to those existing on the market: the coating is made of silica glass and of silver nanoclusters which are embedded in the silica glass. Silica provides excellent thermal and mechanical properties to the coating. The technique used to deposit this coating (RF sputtering) is suitable to almost every kind of substrate (polymers, metals, glasses, etc.). Results will have a clear and immediate exploitation potential to improve or develop new products currently commercialized by the four SMEs : biomedical implants for DiPro, agro/food industry equipments for Alce Calidad and EASReth and personnel protective systems for Aero Sekur. As soon as the anti-septic functionality can be provided to SMEs products, the following new products will be directly put on the market: Di.Pro: new anti-septical artificial anus ALCE and EASReth: new anti-septical coating on surfaces to be used in food handling and processing; Aero Sekur: new anti-septical textiles for Personal Protection Systems (PPS).",Nanostructured anti-septical coatings,FP7,31 October 2012,01 November 2010,1126697.0 NASOFC,University of St Andrews,energy,"Fuel Cells are receiving an enormous amount of commercial and research attention because of their potential to: increase the efficiency with which we use natural energy resources; form an important component of the hydrogen economy; and eventually assist in attaining an environmentally sustainable energy infrastructure. Solid Oxide Fuel Cells (SOFCs) offer additional advantages of fuel flexibility and generation of excess heat which can be used in combined heat and power (CHP) applications. SOFCs typically attain energy efficiencies of 55-60% and of up to 80% when operating in CHP mode. The energy efficiency of a typical internal combustion engine is around 25%. This project will aim to develop new catalytic anode nanostructures aimed at allowing direct use of hydrocarbons and oxyhydrocarbons in SOFCs, so avoiding the efficiency losses and cost implications of a pre-reforming reactor in which hydrocarbons are converted to hydrogen, which is then used to fuel the SOFC. These fuels may initially be fossil fuels but the longer-term aim of the project is to obtain catalysts which enable the use of biofuels - and even of waste-derived fuels - in SOFCs. Anode catalysts must be resistant to deactivation, for example through carbon build-up, must have high surface areas, for good gas-solid reaction kinetics, and excellent ionic and electronic conduction paths to the electrolyte and current collector, respectively. These demands may be met by novel catalytic anodes. These will be synthesised and tested, first for their chemisorption and catalytic properties and then the most promising materials will be evaluated in terms of their electrochemical performance in simple fuel cell systems.",New Nanostructured Catalytic Anodes for Solid Oxide Fuel Cells using Hydrocarbon and Oxyhydrocarbon Fuels,FP6,14 January 2009,15 January 2007,169365.98 NASPE,University of Brescia * Università degli Studi di Brescia,health,"Microcantilever (MC) biosensors are innovative and versatile micro-electro-mechanical systems (MEMS). Due to (nano)mechanical transduction of biochemical reactions they allow sensitive, label-free, direct, real-time and multiplexed detection of molecules as well as specific investigations of molecular interactions and conformational changes. NASPE aims at generating the pre-requisites and supporting the effort to establish MC biosensors as a competitive technology in the field of drug screening by integrating skills and know-how of SMEs and RTD performers which cover leading positions in the fields featured by the project. NASPE outcomes are expected to enable the SMEs to strengthen their position in the international market of drug discovery, to gain access to new market segments and to create new highly skilled jobs in Europe. On the other hand, NASPE research activities will contribute to address inherent fundamental issues of MEMS biosensors, including functionalization, manufacturing and novel applications. The primary aim of NASPE is structured into the following SMART objectives: - Functionalization protocols for silicon and plastic MCs, necessary for performing molecular recognition experiments by MCs. They will be accomplished by months 9 and 18, respectively, and tested on conventional fluorescent essays. - Proof-of-concept of nanomechanical drug screening by MCs, that is the necessary step for designing MC essays. Experiments for silicon and plastic MCs will be assessed and statistically validated by month 12 and month 21, respectively. - Prototype plastic MC arrays, that will be provided by month 15 and tested against commercial silicon MCs. Plastic MCs are expected to have lower cost and enhanced performances with respect to silicon MCs. - 'Field' test of MC drug screening and design of drug discovery kits, that is the ultimate project objective. MC costs/benefits will be benchmarked against the commercially available drug discovery essays.",NAnomechanical Screening of Pharmaceutical Entities,FP7,30 June 2011,01 January 2009,734800.0 NASTAR,Technical University of Denmark * Danmarks Tekniske Universitet,health,"Targeted chemotherapy in combination with external beam radiation therapy (radiotherapy) is a promising approach to significantly improve the therapeutic outcome for cancer patients. To achieve this, it is essential to develop drug delivery technology that specifically delivers the chemotherapeutic drugs to cancerous tissue. Radiotherapy is an indispensable part of modern cancer treatment; however, despite efforts in improving planning and execution of treatment, the unbalance between therapeutic benefit and side effects limits cure rates, and new approaches are needed to bring to fruition the full potential of radiotherapy. Today, there is considerable focus on systemically administered radiosensitizers for enhancing the effect of radiotherapy and clinical investigations have shown promising results; however, radiosensitizer use is hampered by considerable side effects due to lack of drug targeting to the cancerous tissue. In the first phase of this project, the aim is to develop tumor targeted nanocarrier delivery systems of radiosensitizers to enhance their therapeutic potential and provide a more efficient and site-directed effect of radiotherapy. In the second phase of the project, nanocarriers for tumor specific delivery of checkpoint inhibitors of cancer cell repair mechanisms will be investigated as an additional targeting strategy for sensitizing cancer cells to radiotherapy. The idea is to circumvent cell cycle checkpoints of DNA damage induced by tumor radiation and thereby enhance mitotic catastrophe. This approach will in combination with the delivery of conventional radiosensitizer drugs, further lower the radiation dose needed to induce irreversible damage to cancer cells. Thus, the project aims to develop targeted nanocarriers for high precision delivery of radiosensitizing drugs to cancerous tissue for enhancing the effect of radiotherapy. We aim to demonstrate the applicability and clinical potential of this new approach within the project period",Nano-Sensitizer Cancer Cell Targeted Radiotherapy,FP7,31 March 2018,01 April 2013,1498731.0 NASUMECA,Technical University of Munich * Technische Universität München,information and communications technology,"The central theme of this project is elucidating and exploiting the reactivity of metal carbenes on well-defined surfaces. We propose to use surface science techniques in vacuo (mainly scanning tunneling microscopy and spectroscopy, temperature programmed reactions, near edge X-ray adsorption fine structure and X-ray photoelectron spectroscopy) to address olefin metathesis reactions and provide an understanding at the single molecule level. Harnessing the reactivity of the metal carbenes, we will develop methods for growing conjugated single molecule wires from the metal center and assess their electronic properties. The potential applications are highly relevant to the Research Strategy Agendas of the European Technology Platforms concerning sustainable chemistry, nanoelectronics and novel materials. The pairing of the researcher’s experience and host institution’s infrastructure is ideal for this project to fulfill its objectives and it will be a springboard for the researcher to reach a group leader position in the near future.",NAnoscience with SUrface MEtal CArbenes,FP7,05 July 2015,06 January 2011,162242.4 NATAL,TUT Foundation - Tampere University of Technology * TTY-Säätiö - Tampereen Teknillinen Yliopisto,health,"NATAL aims to develop a new core technology of powerful and compact laser sources for the visible and ultraviolet spectral ranges. Such devices are needed for a variety of applications including nano-materials processing, medicine, RGB displays, life sciences, as well as UV lithography and surface chemistry. The lasers envisaged by NATAL represent a radical departure from the existing technologies. Nanophotonic materials and science are the key themes running throughout the proposed programme. The main areas addressed by NATAL include (i) development of innovative nano-structured gain devices (ii) development of advanced micro-optical elements to enable the functionality and control of lasers. Central focus of this programme is the concept of the Optically-Pumped Vertical External Cavity Surface-Emitting Semiconductor Laser (OP-VECSEL). These sources retain the power-scaling, beam quality and intracavity control capability of solid-state lasers, while offer the wavelength versatility, broadband pump absorption and compact gain region supplied by semiconductor technology. NATAL will use the innovative thermally-conductive optical windows bonded directly to the surface of the OP-VECSEL chip. This approach allows to facilitate wavelength extension and power scaling, microchip operation and novel schemes for optical mode control, in addition to integrated device formats with a wide range of functionality. Specific wavelength targets include direct operation in the red (630-670 nm) and frequency-doubled OP-VECSELs operating at 315-335 nm (UV), 470 nm (blue), 520 nm (green), and 610 nm (red). These wavelengths cover important absorption bands in a host of materials significant to nanotechnology (quantum dot and conventional fluorphores, light-emitting polymers, photoresists, biomaterials) and large scale consumer applications.",Nano-Photonics Materials and Technologies for Multicolor High-Power Sources,FP6,31 August 2008,30 June 2005,2731350.0 NATAMA,University of Cambridge,energy,"TTitania thin films, suitably doped and/or endowed with novel nano-scale architectures, are very promising materials for industrial and commercial applications because they may be induced to exhibit a variety of radical new properties. A major impediment to progress is lack of understanding of the relationship between the structure, composition and electronic properties of these systems and the functionalities that they give rise to. A second major obstacle to industrialization is the absence of synthetic methodologies that are reliable, well controlled and amenable to scale up at economical cost. This project is aimed at tackling both the above issues directly. A very wide range of methods ranging from sophisticated ultrahigh vacuum techniques, to electrochemical methods to novel organometallic chemical routes will be used to produce a variety of titania thin film structures, doped, structured, or otherwise modified to yield the desired functional materials. The common features are that the thin films should be capable of photo- activation by visible light and that the method of fabrication is compatible with industrial production. The new multifunctional properties sought include photocatalytic oxidation or reduction activity, photoelectrochemical behaviour, photoconductivity, photochromism, photomagnetic switching, sensing behaviour, photovoltaic response and controlled and 'switchable' wetting behaviour. Exploitation of these properties is of strategic importance to EU companies in the fields of health and environment protection, advanced materials, sustainable energy production and national and personal security. Provision of new knowledge and expertise in the area of nano-engineered multifunctional titania thin films will open important new market opportunities for European SME companies. Additionally, and of equal importance, it will also secure strategic research competences in a fast moving, technologically expanding multi-app",NAno engineered Titania thin films for Advanced Materials Applications,FP6,30 September 2009,01 October 2006,1149939.0 NATCO,Thales SA,information and communications technology,"The main objective of this project is the development of novel transparent conductive oxides (TCOs) with enhanced electrical properties and tuned transparency from UV to mid-IR. The innovative aspect of the project methodology is the strong correlation and interaction between theoretical first principle modelling and experimental studies. Three demonstrators have been selected to show the potential applications of the TCOs, which will be developed in this project, thus opening the way and giving the possibilities for Europe to lead in the new and emerging TCO-based technologies.TCOs show the unique combination of properties: co-existence of optical transparency in the visible region and controllability of electronic conduction from insulator to metal. Transparent conductive oxides continue to be in high demand because of the immediate applications they can find in a variety of new technologies, ranging from thin film coatings and sensor devices, to light detecting and emitting devices in telecommunications. However, the current industry standard, tin doped In2O3 (Indium Tin Oxide or ITO) suffers from the high raw material cost of indium. In addition, the non-optimal conductivity and transparency, and the chemical instability of ITO in some device structures, have limited its potential applications. Moreover, almost all TCOs used nowadays are n-type. The p-type TCOs reported to date have conductivities at least an order of magnitude lower than their n-type counterparts. If p-type materials with high conductivities and controlled transparencies could be manufactured industrially, a variety of new applications would open up, including transparent electronics and opto-electronics, organic light emitting diodes, integrated electro-optical (waveguide) sensors and functional windows. The aforementioned limitations of n-type TCOs and the lack of p-type TCOs with optimum transparent and conductive properties have been the motivation and the driving force for this project.",Novel Advanced Transparent Conductive Oxides,FP6,31 October 2008,28 February 2005,1599239.0 NATIOMEM,DHI Group,environment,"More than 1.2 billion people, mostly in poor regions, suffer from water scarcity, due to a global shortfall of potable water caused by population growth, over-exploitation, and pollution. NATIOMEM proposes to alleviate this by developing novel technology for treating contaminated surface and waste water so that it will be potable. This technology will not require electrical power, chemicals or other logistical support, and hence will be suitable for poor areas lacking infrastructure. The technology uses membranes functionalized with a photocatalytic material, eg. N-doped TiO2 (TiON). Raw water will be directed through the membrane while it is exposed to solar radiation. The membrane will filter out particles and micro-organisms larger than the its pore size, and TiON photocatalysis will kill micro-organisms, decompose and mineralize organic pollutants, and oxidize dissolved metals, thus providing a one-step treatment against a broad spectrum of contaminants. In the NATIOMEM project, functionalized membranes will be developed with two approaches: (1) coating conventional membranes with TiON nanostructured films, using several candidate deposition methods, and (2) electrospinning TiON fibers, from which membranes will be fabricated. The functionalized membranes will be characterized for their morphological, physical, mechanical, chemical, and in particular, their photocatalytic properties, and the most effective will be extensively tested to determine their pollution abatement mechanisms and kinetics. A pilot plant incorporating these photocatalytic membranes will be designed, and field tested in the Middle East and in Africa. The results of these tests will be correlated with potential end-user requirements to set the stage for industrial exploitation. Achieving this result will be a breakthrough in water purification and reclamation technology, advancing far beyond the state of the art with a system which is simple, solar enabled, and chemical free.",Nano-structured TiON Photo-Catalytic Membranes for Water Treatment,FP7,06 June 2015,07 January 2010,2993230.0 NATURALE,Imperial College London,health,"Materials with nanometre-scale dimensions have unique functional properties that can lead to novel engineering systems with highly useful characteristics. Most traditional approaches to synthesis of nanoscale materials, unlike those in biology, require stringent conditions and often produce toxic byproducts. Within biology itself, biomaterials are highly organized from the molecular to the nanoscale, with intricate architectures that allow for optimum functionality. The focus for this proposal on bio-inspired materials is two-fold. In the first instance I aim to rationally design biologically responsive peptides to control the assembly and dis-assembly of bio-inorganic nanostructures and develop fundamental enabling technologies with applications in bio-sensing. The second focus is on exploiting our understanding of the natural biological nanostructures found in the complex extracellular matrix of tissues in order to engineer synthetic biomimetic nanostructures for improved cell growth and tissue regeneration. Outcomes will include greater fundamental understanding of cell-matrix interactions and cell differentiation as well as longer-term clinical impacts. I have begun to establish a creative research team with many developing international links and a record of timely high quality research. If successful with this proposal I will be able to manage my group to its full potential and to expand its influence and vision. The proposed research involves development of important new international collaborations in the basic sciences and is highly multidisciplinary in nature encompassing elements of engineering, biology, chemistry and physics and ranging from high-resolution techniques of surface analysis to peptide design and cell biology.",Bio-Inspired Materials for Sensing and Regenerative Medicine,FP7,30 June 2014,01 October 2008,1643021.0 NATURALE CG,Imperial College London,health,"In Naturale CG I propose transformative bioengineering approaches that will overcome severe limitations in current materials in two main areas, namely 1) Biosensing and 2) Regenerative Medicine. A key focus is on understanding and engineering the biomaterial interface using innovative designs and state of the art materials characterisation methods. Firstly I aim to transform the way that we can currently detect disease through innovations in the design and development of nanomaterials-based biosensors that could be used to detect a number of diseases with global implications, such as cancer, malaria, heart failure and tuberculosis. These innovations in biosensor design will involve both building on our existing highly successful work on plasmonic biosensors and also involve the design and development of completely new polymersome and fluorescent based biosensors. Another key aim of Naturale CG is to design first in kind biosensors for the facile detection of microRNAs. Secondly, the goal of regenerating failing organs before the body as a whole is ready to surrender, is now timelier than ever and one in which the design of new bio-inspired materials can play an important role. In Naturale CG I will build on my previous research in the design of 3-dimensional tissue engineering scaffolds and address an important new direction in the engineering of new bio-inspired conducting polymers as tissue engineering materials to promote cardiac tissue regeneration. First-in-field biomaterials-based innovations generated from this programme could enable far more effective regeneration of functional myocardial tissue which has been notoriously difficult to achieve thus far. Whilst I will lead this grant and the research within it, the proposed innovations are truly multidisciplinary in nature and will be accelerated towards clinical translation through the numerous clinical, scientific and industrial collaborations that I have established.",Engineering Bio-inspired Materials for Biosensing and Regenerative Medicine,FP7,30 June 2019,01 July 2014,1999460.0 NATURALE-POC,Imperial College London,health,"There is growing commercial interest in bio-responsive materials because of their many applications, such as in medical diagnostics at the point of care and in drug discovery and development. Our developed assay technologies manipulate the properties of gold nanoparticles and enzyme-based reactions to detect enzyme activity. Most diagnostics target either expressed antigens (immunodiagnostics) or DNA (molecular diagnostics). Our bio-responsive nanoparticle technology can offer a sensitive, specific and affordable platform for the development of rapid point-of-care tests based on simple colour readouts. Additionally one of the great advantages of our technology is the fact that, in addition to diagnosing disease, it can also potentially help in the search for new drugs to treat those diseases. In contrast to methods that simply measure enzyme concentration, our method actually measures enzyme activity. In this ERC POC our expected outcomes include a number of important commercial milestones and technical developments to expand the platform to other diseases and test its application in high throughput drug screening. This value will carry through in both licensing and spin-out, since these issues are fundamental to any business venture. Furthermore, we propose a balanced plan that includes technical research combined with commercial investigations and identification of appropriate industrial partners. At the conclusion of this work, we will be in a much stronger position to immediately commercialise this technology, bringing its benefits to the broader healthcare market.",Bridging the gap in nanoparticle-based enzyme biosensing,FP7,31 March 2014,01 April 2013,147918.0 NATURE NANODEVICES,University of Rome Tor Vergata * Università degli Studi di Roma Tor Vergata,health,"Late diagnosis and difficult treatment represent major obstacles in the fight against cancer. I propose here the development of self-regulated theranostic nanodevices supporting both early cancer diagnosis and targeted, tumor-cell-specific drug-release. Specifically, I will exploit the 'designability' of nucleic acids to design and optimize molecular nanodevices that undergo binding-induced conformational changes upon target binding and, in doing so, signal the presence of a specific tumor marker or release a toxic therapeutic cargo. The inspiration behind my approach is derived from nature, which employs similar nanometer-scale protein and nucleic-acid-based 'switches' as devices to detect –and respond to- specific molecules even against the complex background 'noise' of the physiological environment. Furthering on this 'nature-inspired' synthetic biology view I will also exploit naturally occurring regulatory mechanisms (e.g., allostery, cooperativity, etc.) to tune and edit the dose-response curve of these nanodevices, improve their analytical sensitivity, and optimize drug-release efficiency. In summary, I will use biomimetic 'tricks' taken directly from nature to move beyond the state-of-the-art of sensor design, with the goal being improved diagnostics and 'smarter, ' more effective drug delivery. Achieving these goals will require multidisciplinary expertise in the field of analytical chemistry, biophysics, electrochemistry, bioengineering, computational chemistry and synthetic biology. In my career I have demonstrated skills and expertise in similarly complex projects and in each of these challenging fields. Finally, the development of the proposed nanodevices will significantly impact the safety, compliance and efficacy of therapies and medical procedures bringing to scientific, technological and socio-economic benefits.","Nature-inspired theranostic nanodevices for tumor imaging, early diagnosis and targeted drug-release",FP7,31 March 2019,01 April 2014,1458600.0 NAVOLCHI,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),photonics,"The NAVOLCHI project explores, develops and demonstrates a novel nano-scale plasmonic chip-to-chip and system-in-package interconnection platform to overcome the bandwidth, foot-print and power consumption limitations of todays electrical and optical interconnect solutions. The technology exploits the ultra-compact dimensions and fast electronic interaction times offered by surface plasmon polaritons to build plasmonic transceivers with a few square-micron footprints and speeds only limited by the RC constants. Key elements developed in this project are monolithically integrated plasmonic lasers, modulators, amplifiers and detectors on a CMOS platform. The transceivers will be interconnected by free space and fiber connect schemes. The plasmonic transceiver concept aims at overcoming the challenges posed by the need for massive parallel interchip communications. Yet, it is more fundamental as the availability of cheap miniturized transmitters and detectors on a single chip will enable new applications in sensing, biomedical testing and many other fields where masses of lasers and detectors are need to e.g. analyze samples. Economically, the suggested technology is a viable approach for a massive monolithic integration of optoelectronic functions on Si substrates as it relies to the most part on the standardized processes offered by the silicon industry. In addition, the design and production cost of plasmonic devices are extremely low and with the dimension 100 times smaller over conventional devices they will require much lower energy to transfer data over short ranges of multi-processor cluster systems. The project is disruptive and challenging but it is clearly within the area of expertise of the consortium. It actually builds on the partners prior art such as demonstration of the first nano-scale plasmonic pillar laser. This project has the potential to create novel high-impact technologies by taking advantage of the manifold possibilities offered by plasmonic effects.",Nano Scale Disruptive Silicon-Plasmonic Platform for Chip-to-Chip Interconnection,FP7,31 July 2015,01 November 2011,2400000.0 NAWADES,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,environment,"The main objective of the NAWADES project is to study, design, produce, and test new water desalination filter technology from four points of view:",Nanotechnological Application in WAter DESalination,FP7,09 June 2018,10 January 2012,0.0 NBC-REGEN4,University of Sheffield,health,"The interdisciplinary proposal NBC-ReGen4 is based on the existing expertise in materials science of the incoming European Fellow (Dr. Piergiorgio Gentile) in combination with the host laboratories knowledge of biocompatibility assessment and medical device development (University of Sheffield-Scientist in charge: Prof. P.V. Hatton). NBC-ReGen4 is a timely project with respect to the scientific and technological advance on the state-of-the-art and with clear translational relevance to industry and ultimately patients. It aims to produce, characterise and evaluate a series of nanostructured composites with significantly improved properties compared to the existing state-of-the-art, specifically including suitable membranes for guided bone regeneration. Conceptually, the adaptation of nanostructured composite membranes for the development of functional devices in different applications represents a major step forward in the increasingly competitive field of tissue engineering and regenerative medicine. It is also an ideal time to train a talented materials scientist in new methods related to biological evaluation of a biomaterial, as well as transferable skills that will significantly boost his career prospects and opportunities to contribute to society. In detail, in NBC-ReGen4 the innovative composite membranes will be based on commercially available or in-house fabricated calcium phosphate particles incorporated into a resorbable medical polymer matrix (polyglycolic acid or poly(lactide co-glycolide)) further processed by electrospinning. The obtained composite membrane will consist in bilayered structures that can be modified and characterised for specific applications where bone tissue regeneration is required on only one side. Surface functionalization of the different layers to enhance specific properties (such as biomimetic and anti-inflammatory properties) by low-risk and environmentally-friendly techniques, will be also implemented.",Nanostructured & Biomimetic Ceramic-Polymer Composites for Bone Tissue Regeneration,FP7,31 August 2014,01 September 2012,200371.0 NCC-FOAM,NetComposites Ltd.,manufacturing,"Cellulose, the primary structural component of plants, is the most ubiquitous and abundant organic compound on the planet. When cellulose fibrils are processed under carefully controlled conditions, it is possible to release highly crystalline nano-particles known as “nano crystalline cellulose (NCC)â€. Recently, NCC-FOAM partners have developed a unique technique for self-assembling NCC into highly ordered “puff-pastry-like†layered cellular structures, i.e. foams. This self-assembly process is controllable, and the final cell structure can be modified to produce open or closed cell geometries depending on the requirements of the end application. Furthermore, the constituent NCC nanofibres are sustainably sourced from paper mill or forestry waste.",Self-assembly of nano crystalline cellulose for lightweight cellular structures,FP7,09 June 2018,10 January 2013,0.0 NEAL-TYPE,Uppsala University * Uppsala Universitet,information and communications technology,"The proposed programme of research will develop a comprehensive theory of models for two extensions of classical dependent type theory: dependent type theory with non-extensional equality, and linear dependent type theory. It will do this by altering the existing theory of models for dependent types in two fundamental ways: firstly, by shifting from one-dimensional to higher-dimensional categories, and secondly, by shifting from cartesian structures to monoidal strucures. It will then look for applications for this generalised theory in, amongst other areas, categorical logic, homotopy theory and quantum computing This programme will be implemented by the Fellow working in close collaboration with members of the host organisation; the Fellow will bring skills and experience in the area of higher-dimensional category theory, enriched category theory, and linear logic; the host organisation, skills and experience in dependent type theory. This project fits tightly with the objectives of the Specific Programme of the EIF and the broader Human Resources and Mobility Work Programme, by providing the Fellow with an opportunity to undergo training through research, thereby diversifying his technical expertise from higher-dimensional category theory to the complementary area of dependent type theory and its applications in theoretical computer science. By providing him with the opportunity to relocate from the UK to Uppsala, Sweden, it will allow this training to take place in the location most suitable for his needs, namely at an internationally recognised centre of excellence in dependent type theory. Moreover, by promoting a cross-fertilisation of the still distinct disciplines of categorical logic and dependent type theory, it will lead to the development of a new area of research and the creation of European centres of excellence in this new area, thereby increasing Europe and apos; s competiveness and attractiveness to researchers in the field.",Non-extensional and linear models for Dependent Type Theory,FP6,17 October 2008,18 October 2006,159684.0 NEARFIELDATTO,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,photonics,"Electron dynamics in metals and nanostructures take place on attosecond timescales. Until today, these extremely fast processes are little understood let alone utilized. With NearFieldAtto, strong-field driven phenomena at nanoscale metal structures will be explored to elucidate collective electron dynamics and to induce optical-field-driven currents -- on attosecond timescales. We will investigate the near-field of a nanotip, resulting from the collective dynamics, both in amplitude and phase. Conversely, we will use the tip as a nanometric sensor to map out the electric field inside the focus of a pulsed laser beam and will directly measure the local phase. In two-tip and molecular junctions, we will explore the ultrafast steering of electronic currents by optical fields, both over a nanometric gap and inside a molecule, taking advantage of the large near-field enhancement the systems offer. My group has recently shown that attosecond physics phenomena can be observed at solids, namely at nanoscale tips [Krüger et al., Nature 2011]. Hence, in NearFieldAtto we will employ techniques well known from attosecond physics with isolated objects, like gas-phase atoms and molecules, to steer laser-emitted electrons with the electric field of few-cycle laser pulses. We will use these electrons as nanometric probes to investigate optical properties of the solid state system and compare the results with those of isolated objects in gas-phase measurements. With two tips facing each other, we will realize a nanometric junction over which we will steer electrons with the optical field. A molecule placed between two tips will enable the investigation of a novel, ultrafast switching mechanism. NearFieldAtto will bring attosecond physics a leap forward as compared to the state-of-the-art, will introduce strong-field physics into (quantum-)plasmonics, and will open the door towards lightwave or petahertz nano-electronics in metallic and molecular nano-systems.",Attosecond physics at nanoscale metal tips - strong field physics in the near-field optics regime,FP7,31 March 2019,01 April 2014,2012733.0 NEAT,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The project aims at developing 'Nanoparticle Embedded in Alloy Thermoelectric (NEAT)' materials to harvest energy in the KW range. Thermoelectric Generators will help to recover some of the huge amount of wasted high-grade thermal power leading to significant savings in fuel and Green House Gas emissions. These innovative materials will be designed to perform efficient waste heat recovery in high thermal differentials provided by high temperature industrial processes and automotive engines. Conventional thermoelectric materials are toping ZT values of 1 since several decades. Recently, ZT values as high as 3 at 550K have been reported for thin film nanostructured materials. However, bulk materials are far from reaching a similar performance. NEAT is an innovative nanocomposite alloy capable of attaining ZT>3 at high and medium temperatures. The material concept is based on the joint optimization of nanoinclusions and grain boundaries in order to maximize phonon scattering at multiple length scales, without increasing electron scattering significantly. NEAT will focus on: - Mg2Si nanoparticles in n-Mg2SiSn alloy matrix, for medium temperature range (500-800K) - Ge and Silicide nanoparticles in SiGe alloy matrix, for high temperature range (900-1200K) - A graded nanocomposite of both medium and high temperature materials, for high thermal gradients accommodation. The concept achievement will require manufacturing process innovations enabling the inclusion of well controlled nanoparticles in a host polycrystalline alloy and the preservation of the initial architecture during the sintering. It will benefit from advanced theoretical simulation providing fundamental physical understanding, and materials development guidance. The demonstration of the nanocomposites thermoelectric performances in proof of concept thermoelectric generators and the assessment of its energy pay-back will unambiguously state the potential industrial impact of the project outcomes.",Nanoparticle Embedded in Alloy Thermoelectrics,FP7,31 March 2014,01 April 2011,2882506.0 NECOBAUT,Fundación Tecnalia Research & Innovation,energy,"The aim of NECOBAUT Project is to develop a new concept of battery for automotive based on a new metal/air technology that overcomes the energy density limitation of the Li-ion battery used at present for Electrical Vehicles. Some metal/air cells were developed in the past, but did not give the demanded requirements for commercial use. Two decades of improvements in materials for electrodes, electrolytes and batteries and mainly in nanomaterials have helped for developing a battery that should fulfil the requirements of the car industry. The technology that is developed in the project addresses mainly the design and manufacturing of both electrodes of the battery: the negative electrode composed by the selected metal, and the air cathode with the catalyst supported on a carbonaceous material. Air is necessary for running the battery and allows having a very light battery, which is essential for the automotive industry. Another important advantage is the low cost of the materials used for manufacturing the battery: the selected metal, carbon support electrode and potassium hydroxide as electrolyte. All these materials are recyclable. The consortium is composed of 8 partners (3 IND, 2 Universities and 3 RTD) covering the complete value chain: battery manufacturer, nanomaterials development (i.e.; nanocatalys, additives and support materials such us carbon), modelling and simulation for cells and batteries design, scaling-up, safety and risks studies for batteries. A proof-of-concept metal/air cell is manufactured and tested in the project. In addition, the battery concept is validated for automotive application. Although the main market for the battery developed by NECOBAUT is the car industry, it could be also used for stationary electricity storage (photovoltaic and wind farms, and buildings).",New Concept of Metal-Air Battery for Automotive Application based on Advanced Nanomaterials,FP7,30 September 2015,01 October 2012,2121013.0 NEDFOQ,Lancaster University,information and communications technology,"This research proposal addresses non-equilibrium processes occurring in one-dimensional quantum fluids. The interest to this area has surged in recent years due to the rapid development of fabrication and measurement techniques in nanophysics and physics of ultra-cold atomic gases. Nanoelectronics devices (such as quantum point contacts, nanotubes and organic nanowires) and ultracold gases in elongated optical traps are the experimental systems where one-dimensional quantum fluids are encountered. While the main focus of nanoelectronics has always been on the electrical and spin transport, with only limited access to other aspects of non-equilibrium dynamics, the amazing degree of control over atomic systems has transformed the physics of one-dimensional fluids into a rapidly expanding universe of non-equilibrium phenomena. Quantum quenches, explosions and collisions of atomic clouds, diffusion and drift of quantum impurities, motion and decay of solitary waves have been observed and mapped in real time measurements. The fundamental value of the research in this direction lies in the strongly correlated nature of one-dimensional quantum systems, which makes their kinetic theory a largely unexplored territory. For these systems, the application of traditional tools of the kinetic theory, such as the Boltzmann collision integral and non-linear equations of hydrodinamics meets with serious conceptual difficulties. Indeed, it is usually impossible to represent the low-energy excitations of a one-dimensional system as a collection of weakly interacting quasiparticles. It is also impossible to consistently quantize non-linear hydrodynamcis within the standard framework of perturbative quantum field theory. The main goal of this project is to develop methods bypassing these difficulties and to formulate a theoretical framework suitable for the description of non-equilibrium phenomena in one dimension.",Non-equilibrium dynamics of quantum fluids in one dimension,FP7,12 July 2016,01 January 2012,679639.8 NEELEFFECTINTHESKY,Neelogy SA,transport,"The objective of this project is to leverage on a breakthrough nanotechnology invented by a French SME, Neelogy, for high performance isolated magnetic sensors with no remanence, and adapt it for harsh environmental avionics constraints (high amplitude variation of operating temperature -60° to +125°C, depression, humidity, vibration and EMI/EMC constraints).",Magnetic Sensors with No Remanence for Aircraft Application,FP7,06 May 2014,12 June 2010,0.0 NEFELE,Aerocare International Ltd.,health,"In recent years, word of aircraft water quality issues has spread, generating negative media coverage, attracting the attention of regulators worldwide, and giving airline passengers a new cause for concern. Health enforcement agencies are currently in the process of drafting new, more stringent quality regulations for aircraft potable water and the world's other regulators will follow suit. Aircraft potable water is typically loaded from municipal systems which are susceptible to contamination. While municipal water quality has always been a concern in some parts of the world, it is now becoming an issue in North America as well. As recent outbreaks of waterborne disease in carries Canada and the US illustrate, dependence on any municipal water supply carries an inherent risk. Even when the source water is clean, contamination can make its way into a water supply during ground handling because of contaminated water trucks, contaminated hoses, or from improper handling procedures by ramp crew. The aircraft water system itself can be the source of contamination. Microorganisms can grow within the water tanks, water lines, and even the water filters. This situation is exacerbated by the standard, air pressurized water systems that allow water to remain still in the tank and distribution lines until a faucet is opened and the water begins to move. Bacteria thrive in such conditions, which also encourage bacterial regrowth almost immediately after system cleaning. The present project aims to provide an advanced treatment system which will make use of core/sheath polymer nanofibres which are filled with biocidal substances. This will provide a way of maintaining a constant level of biocide in the water without the need to dose or measure the quantities present. In addition the nanofibres will provide a means of physical entrapment for viruses.",Nano- Electrospun Filter for Efficient Liberation & Encapsulation of acticides for water treatment in transportation applications,FP7,30 November 2013,01 December 2011,830011.0 NEMCODE,Jožef Stefan Institute,photonics,"Herein I present a new approach towards 2D colloidal crystals with selectively created point and line defects. This project reaches beyond the state of the art in the field of colloidal crystals for photonic applications. However, in order to exploit these materials for photonic application point and line defects have to be created to guide light through the material. So far no bottom-up approaches to selectively created defects has been reported; in fact, despite the preparation of colloidal crystals usually involves self-assembly techniques the generation of point and line defects has been reached only using top-down techniques (i.e. photolithography, photochemical etching, focussed ion beam etching, etc.). The assembly will be carried out in reactive (polymerisable) liquid crystalline matrix by means of laser tweezers; UV-curing will cause the polymerisation of the reactive liquid crystal molecules yielding an aligned liquid crystalline network which will embed the assembly, stabilising it. Organic chemistry synthesis will be applied to generate photonitiator and polymerisable units to be installed on the surface of the colloids. The assembly technique reported by Prof. MuÅ¡eviÄ will ensure a one-by-one construction of the colloidal crystals. Using this technique particles with a lower interaction with the generated polymeric network can be incorporated in specific position of the assembly. These particles can subsequently be removed by means of laser tweezers, generating point and line defects in the 2D colloidal crystal. The interdisciplinarity of the proposal which combines Organic Chemistry with Experimental Physics is one of the points of strength of the project. Positive outcomes will represent a leap forward for photonic and nanotechnology industry in the ERA. The host offers great opportunities to collaborate with industry allowing the EU to increase its level of competition with other producers of this kind of photonic materials.",Controlled Assembly and Stabilisation of Functionalised Colloids in Nematic Liquid Crystals,FP7,05 May 2015,06 May 2013,154137.0 NEMESIS,University of Bath,energy,"The aim of NEMESIS is to establish a world leading research center in ferroelectric and piezoelectric materials for energy harvesting and energy generation. I will deliver cutting edge multi-disciplinary research encompassing materials, physics, chemistry and electrical engineering and develop ground breaking materials and structures for energy creation. The internationally leading research center will be dedicated to developing new and innovative solutions to generating and harvesting energy using novel materials at the macro- to nano-scale. Key challenges and novel technical approaches are: 1. To create energy harvesting nano-generators to convert vibrations into electrical energy in hostile environments (e.g. wireless sensors in near engine applications). 2. To enable broadband energy harvesting to generate electrical energy from ambient vibrations which generally exhibit multiple time-dependent frequencies. 3. To produce Curie-temperature tuned nano-structured pyroelectrics to optimise the electrical energy scavenged from temperature fluctuations. To further enhance the energy generation I aim to couple thermal expansion and pyroelectric effects to produce a new class of thermal energy harvesting materials and systems. 4. To create nano-structured ferroelectric and piezoelectric materials for novel water-splitting applications. Two approaches will be considered, the use of the internal electrical fields present in ferroelectrics to prevent recombination of photo-excited electron-hole pairs and the electric charge generated on mechanically stressed piezoelectric nano-rods which convert water to hydrogen and oxygen.",Novel Energy Materials: Engineering Science and Integrated Systems (NEMESIS),FP7,31 January 2018,01 February 2013,2266020.0 NEMIAC,IBM Research GmbH,information and communications technology,"The first fully electronic vacuum tube based computer ENIAC (Electronic Numerical Integrator And Calculator) consumed 200 kW of power. Since then power consumption has become the major bottleneck in state-of-the-art microelectronic technology as leakage power is approaching dynamic power in nanometer technologies. This is particularly an issue for emerging applications for smart components such as autonomous sensor nodes, wireless communications devices, and novel mobile computers which all require logic circuits with dramatically improved energy efficiency.",Nano-Electro-Mechanical Integration And Computation,FP7,12 July 2016,09 January 2011,0.0 NEMINTEM,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"Nanocharacterization techniques are becoming increasingly important. They help us to determine local atomic arrangements, element compositions as well as electronic structures. High-Resolution Transmission Electron Microscopy (HRTEM) is the most powerful and widely accepted technique. However, until recently in-situ HRTEM did not show sufficient resolution to image changes on the atomic scale. In the last five years, my group has pioneered advanced specimen holders towards in-situ HRTEM. We have leading expertise in obtaining the high resolution in a range of controllable environments: temperatures, pressures, and liquids. In addition, combinations with other types of parallel measurements were pioneered, such as in-situ low-noise electrical characterization. Clearly it is indeed possible to operate the HRTEM as a nanolaboratory. It allows to really see what one is measuring. With this proposal I want to realize the equipment and methodology to perform nano-electrical measurements of nanostructures in-situ in a HRTEM. The NanoElectrical Measurements in a Transmission Electron Microscope (NEMinTEM) will be applied to nanostructures of a range of materials. Furthermore the electron beam will be used to make well-controlled modifications of the nanostructure. The effects of these modifications on the electrical properties will be measured simultaneously. Semiconductor nanowires, graphene, metallic bridges and nanoelectrodes, and oxide multilayers will be studied, providing challenging examples with possible high-impact results It is to be expected that once NEMinTEM is mature, it will be applied to many more materials.",In-situ NanoElectrical Measurements in a Transmission Electron Microscope,FP7,03 July 2018,04 January 2011,2500000.0 NEMIS,Technical University of Munich * Technische Universität München,photonics,"The objectives of the NEMIS project are the development and realisation of compact and packaged vertical-cavity surface-emitting semiconductor laser diodes (VCSEL) for the 2-3.5µm wavelength range and to demonstrate a pilot photonic sensing system for trace gas analysis using these new sources. The availability of electrically pumped VCSELs with their low-cost potential in this wavelength range that operate continuously at or at least near room-temperature and emit in a single transverse and longitudinal mode (i. e. single-frequency lasers) is considered a basic breakthrough for laser-based optical sensing applications. These devices are also mode-hop-free tuneable over a couple of nanometers via the laser current or the heatsink temperature. They are therefore ideal and unmatched sources for the spectroscopic analysis of gases and the detection of many environmentally important and/or toxic trace-gases, which is a market in the order of 10 million Euro today with an expected increase into several 100 million Euro with the availability of the new VCSELs. The semiconductor technology underlying the VCSELs relies on GaSb-based quantum well structures and the devices are based on insulating apertures as well as on buried tunnel junctions for the lateral current and mode confinement. The project is organized into six workpackages dedicated to specifications/design, epitaxy, VCSEL technology, VCSEL characterisation, applications, and project management. The consortium comprises seven complementary and highly skilled partners from five European countries: Technische Universität München, Germany (buried-tunnel-junction VCSEL), Universite Montpellier 2, France (insulator-confined VCSEL), Institute of Physics of the Academy of Sciences, Czech Republic (VCSEL characterisation), Chalmers University of Technology, Sweden (Design), VERTILAS GmbH, Germany (VCSEL packaging and characterisation), Omnisens, Switzerland (Applications) and Siemens AG, Germany (Applications).",New mid-infrared sources for photonic sensors,FP6,31 December 2009,31 August 2006,2000000.0 NEMO,Free University of Brussels * Vrije Universiteit Brussel,photonics,"Micro-optics is a generic technology that allows the manipulation of light and the management of photons with 'micron'- and 'sub-micron'-scale structures and components. Micro-optics is therefore the corner-stone enabling technology to interface the macroscopic world we live in with the microscopic world of opto- and nano-electronic data processing circuits. It is recognized as the key-link between photonics and nano-electronics, the two dominating information technologies in tomorrow's society. This Network of Excellence on Micro-Optics NEMO aims at providing Europe with a complete Micro-Optics food-chain, by setting up centers for Optical Modelling and Design; Measurement and Instrumentation; Mastering, Prototyping and Replication; Hybrid Integration and Packaging;Reliability and Standardization. A first objective of the NEMO network is to make these service and technology centres accessible to academic research institutes, SME's, and large companies to enhance the competitiveness of photonic-based products and the durable embedding of novel photonic functionalities in a myriad of products. A second objective is to use these service and technology centres to support the network's six long-term application-oriented research topics on micro-optics: Mid-Infra-Red micro-optics, Sub-wavelength structured optical surfaces, Platforms for optical MEMS, Non-conventional micro-optical elements, Micro-optical structures for sensing, and Micro-optic interconnects. These long-term research topics aim at widening the scope of present-day research and at introducing novel concepts and components, thus creating new photonic functionalities applicable in virtually any region of the optical spectrum and beyond. With its long-term research NEMO is targeting a wealth of novel optical and photonic applications to increase the quality of daily life.",Network of Excellence for Micro-Optics,FP6,31 January 2009,31 August 2004,6400000.0 NEMO,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"Gastrointestinal (GI) malignancy imposes a significant impact on the Well-being of the European members with enormous economic burden. The World Health Organization reported 940,000 deaths of colorectal cancer in 2000; 870,000 from the stomach, and 410,000 of oesophageal origin. Ageing of the population means that death rate will continue to rise. A report of the IARC (France) is indicating insuffciant complaince to colorectal cancer prevention programs, due to lack of a simple, patient friendly diagnosis method. The objectives of the NEMO project is to develop an advance cancer screening method friendly enough to significantly increase compliance , simplify the the diagnosis procedure and increase the sensitivity and specificity of early detection. The concept of the NEMO approach is to combine capsule endoscopy with nano-based molecular recognition that will highlights cancerous and precancerous lesions in the GI tract thus considerably increases the accuracy and ease of diagnosis. The system will merge two technological platforms: Nanotechnology for targeting and marking the infected organ and Capsule Endoscopy to detect the marked disorder. By fusion of imag with data of molecular analysis a new medical tool is formed. A major task of the project is to develop liposome-based nanocontainers, labelled with targeting agents and filled with dyeing material. The administered nanocontainers will be tailored to react with the target and change the dye, thus marking the infected organ. Another task is to develop a capsule based on Narrow Band Imaging. This advanced capsule will provide both: visual images of the GI tract and detection of the dyeing material. Fussing the information together, a high sensitive cancer detection system will be developed. The participants of this ambitious program are world leaders' research, industrial organizations and SMEs with proven history of turning innovative ideas into viable medical devices.'",Nano based capsule-Endoscopy with Molecular Imaging and Optical biopsy,FP6,31 January 2010,01 November 2006,2832020.0 NEMO,Public higher learning institute of Pisa * Scuola Normale Superiore di Pisa,photonics,"The aim of this project is the realization of a new class of electrical devices, in which mechanical deformation of a nano-object are used to tune its electronic transport properties. This is done through the use of radiation-pressure actuated optical forces on suspended one-dimensional electronic systems, such as semiconductor nanowires. While research in opto-mechanical systems and electro-mechanical systems is advancing at a rapid pace, the joining of the two fields is still lacking and opto-electro-mechanical devices are scarcely investigated. In these devices spatial deformations control the electronic properties of nano-object; suspended nanowires, for example, can oscillate (guitar string modes) modifying their distance with a back-gate electrode, linking mechanical deformation to an effective gating field which, in properly designed system, can control the flow of single electrons (Coulomb blockade). This proposal considers the realization of on-chip systems in which this dynamic is controlled by the use of optical forces, to obtain a precise and reliable tool to address the nanometric displacement of the object. Exploiting the capability of nanowires to sustain fiber-like optical modes, a coupling of photonic modes between an optical waveguide/microcavity is envisioned. Apart from its interest as a mini-invasive waveguide detector, this will open the route to the investigation of mechanical modes of nanowires coupled with optical waveguides/cavities or in LC resonant circuits, with the achievement of controlling the vibrational state of the object by shining light into the optical system. The final goal is the realization of optically controlled electro-mechanical transistors, both field-effect and single electrons, which could represent an absolutely new kind of device for sensing and a new exciting platform for fundamental physics invetigations.",Nanowire electro-mechanical-optical systems,FP7,09 May 2014,10 May 2012,178760.0 NEMOLIGHT,Grenoble Institute of Technology * Institut polytechnique de Grenoble,environment,"We propose a novel multi-disciplinary approach for the optimisation of light alloys for structural applications in the objective of weight savings and reduction of greenhouse gas emissions for transportation applications. This approach will combine advanced experimental investigations in the fields of physical metallurgy and materials electrochemistry and the development of a mesoscopic modelling tool, and will be applied to precipitation-hardening Aluminium alloys. The development of nano-scale, multi-phase precipitate microstructures will be quantitatively characterised by advanced experimental techniques, including time-resolved synchrotron X-ray scattering, nuclear magnetic resonance, atom probe tomography and electron microscopy. It will be modelled by a physically-based approach, going well beyond the state-of-the-art by addressing the complexity of the sequence of metastable phases and of the competitive formation of multiple phases in multi-constituent alloys. The project will be carried out first on a model Al-Cu-Sn alloy and then applied on industrial alloys. The project will be carried out in two institutions that are world leading in their respective fields of physical metallurgy and design of light alloys. It will involve active training of the main researcher on multi-disciplinary experimental research tools, on modelling of phase transformations in metals, and on research administration. The project will improve the excellence of the return host (Grenoble Institute of Technology) in the field of light alloy research, improve its international links and recognition, and will impact Europe’s capabilities in the design and production of high performance light alloys. The project will improve the prospects of the main researcher to reach a prominent academic position in his field of research and teaching.",Novel Experimental and Modelling approach for Optimisation of Light alloys,FP7,08 October 2012,08 November 2010,138821.8 NEMOSLAB,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),photonics,"The objective of this proposal is the development of silicon based integrated optical biosensors capable of detecting single binding events as well as label free biomolecular interactions. The transducer comprises arrays of monolithic silicon optocouplers interfaced with microfluidic channels directly integrated onto silicon. The optocouplers consist of nano-engineered silicon light emitting devices optically coupled to silicon nitride optical fibers and silicon detectors. The optical fibers are specifically biofunctionalized with a variety of biological capture probes. Nanoparticles will be employed as labels for highly sensitive detection of analytes, including single binding event sensing, whereas label free detection will be targeted through patterning of the waveguide surface. Such an integrated optical device provides for the simultaneous detection of a number of biological analytes without the need of external optical components. The main project output is a monolithic silicon microphotonic biochip integrated with microfluidic channels and recognition biomolecules as well as the associated readout and control electronics assembled in a portable bioanalytical microsystem to be tested with specific panels of pituitary hormones, steroid hormones and DNA. The main milestones are the sensitive and wide dynamic range detection of analytes through the monolithic optical transducer, affordable silicon multianalyte biochips, and portable readout and control electronics.",NanoEngineered Monolithic Optoelectronic transducers for highly Sensitive and LAbel-free Biosensing,FP6,30 June 2009,30 December 2005,1900000.0 NEMS INERTIAL IMAGE,Bilkent University * Bilkent Üniversitesi,information and communications technology,"Nano-electromechanical Systems (NEMS) are extremely sensitive detectors of physical parameters. In recent years, the applications of NEMS in mass sensing have gained importance through demonstrations of mass sensitivities at the atomic level and mass measurements of single protein molecules. These demonstrations show that is possible to perform biochemical analysis through NEMS mass measurements (NEMS Mass Spectrometry) especially for physiologically important large molecules and biostructures. The NEMS literature so far has always treated these large molecules as point-particles; however considering the miniaturization trend of NEMS and the significant size of targeted large molecules, this assumption is getting less applicable for experiments. In this project, we demonstrate how we can theoretically and experimentally measure the total mass of an arbitrary mass distribution on NEMS through simultaneous measurements of multiple modes. Furthermore we show that this method can be used to obtain important spatial information about the measured molecule, such as its average position, the variance of its density distribution, the skewness of the molecule etc. This extra characterization modality expands the capabilities of NEMS devices: one can obtain, for instance, the effective density of the sample being measured by combining mass and extent (variance) information. With the proposed technique it is possible to obtain an approximate image of an adsorbed molecule by reconstructing the density profile using the measured moments of the distribution. In the project, multimodal NEMS devices will be fabricated, electronic and vacuum systems to perform the measurements will be constructed and up to the third moment (mass, position, variance and skewness) of different analytes (nanoparticles and biomolecules) will be obtained. The project will be the first step for the development of a novel, powerful NEMS sensing tool and facilitate the integration process of the researcher.",Inertial Imaging with Nanoelectromechanical Systems,FP7,02 April 2020,03 January 2014,100000.0 NEMSIC,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"NEMSIC addresses the future intelligent sensor and actuator systems in which solid-state semiconductor micro/nanodevices and micro/nano-mechanical devices are co-integrated for new functionalities and increased performance. The project proposes the exploration and development of low power sensing micro/nanosystems based on Nano-Electro-Mechanical (NEM) structures integrated on a Silicon-On-Insulator (SOI) or Silicon-On-Nothing (SON) technological platform. The applications that drive the technological NEM-based smart system demonstrators are gas (COx, NOx, SOx) and biological sensing (DNA, proteins and other molecules), dedicated to critical environment monitoring and applications in the fields of genetics, pharmacology and drug discovery. NEM technology will be combined with silicon CMOS technology involving novelty and scientific/technical challenges at three levels: (i) system level, addressing the challenge of true nano-micro interfaces, where signals detected by arrays of nanostructures are processed by smartly designed low power CMOS circuitry, (ii) device level, where novel true hybrid NEM-FET devices support new highly sensitive detection scheme and power management via sleep switches and (iii) technology level, where nanotechnology processes (top down processed nanobeams and nanogaps, featuring sub-100nm dimensions) will be developed and combined with advanced functionalization techniques for dedicated sensing that stays compatible with CMOS in future IC-embedded or post-IC approaches. The reliability of the NEM structures, combined with prospects for 0-level packaging are studied as key challenges for the success of such Nano-electro-mechanical-system-integrated-circuits (NEMSIC). Finally, NEMSIC is expected to provide the end-users with flexible design methodologies based on advanced but well-controlled SOI or SON technology platforms, with predictable performances and associated cost effectiveness.",Hybrid Nano-Electro-Mechanical / Integrated Circuit Systems for Sensing and Power Management Applications,FP7,31 March 2012,01 June 2008,3899998.0 NEMSMART,Bilkent University * Bilkent Üniversitesi,information and communications technology,"This project focuses on the development of high-reliability low-contact force DC-contact, i.e., metal-to-metal contact RF-NEMS (Radio Frequency Nanoelectromechanical System) switches, which are the main building blocks of key enabling component of the next-generation cognitive wireless communications systems, i.e. the interface between the transceiver and the free space; namely NEMS-integrated multifunctional reconfigurable antenna (MRA). An MRA combines multiple functions into a single antenna with the capability of dynamically altering its radiation, polarization, and frequency characteristics. The reconfigurability in performance properties is achieved by morphing the physical structure of the MRA through DC-contact RF-NEMS switches. The major objective of this project is to significantly improve the reliability of DC-contact RF-NEMS switches with high RF-power handling capabilities. To this end, we will optimize the mechanical switch design using novel architectures, investigate different electric contact metallurgies, employ nanoparticle-based lubricants, and develop new nanofabrication processes optimized for avoiding two primary failure mechanisms: stiction and increased contact resistance. The targeted actuation voltage and the switching speed are less than 10 Volts and faster than 100 nano-seconds, respectively. Hot-switched life cycle tests for various RF-power levels will be performed, with the goal of achieving more than 108 hot-switched cycles at 1-Watt RF-power. The proposed high-reliability NEMS switches, once successfully developed, can be easily integrated into antenna architectures to realize MRAs, thereby resulting a major breakthrough in antenna design and implementation since the invention of legacy antennas by Marconi and Hertz.",Development of High-Performance and High-Reliability NEMS Switches for Smart Antenna Structures,FP7,02 April 2016,03 January 2010,100000.0 NEMSQED,Aalto University * Aalto-yliopisto,information and communications technology,"At a low temperature, nearly macroscopic quantum states can be sustained in superconducting (SC) Josephson junctions. Recently, these superconducting qubits have been coupled to electromagnetic resonators, in a manner analogous to cavity Quantum Electro Dynamics (QED) which describes the interaction between atoms and quantized oscillation modes in the quantum limit. On the other hand, there is yet no experimental evidence of a mode of a mechanical oscillator, such as that of a miniaturized vibrating string, to be chilled down to its quantum ground state. The main part of the proposal involves the use the coupling of Nanomechanical Resonators (NR) to SC qubits employed as artificial atoms in order to address the quantum-classical interface in mechanical motion. Similarly as the SC qubit can exchange quanta with electrical oscillators, it can, in principle, communicate with mechanical modes. The research will begin with demonstrating this kind of electromechanical interaction. In order to tackle experimental surprises, I plan on launching two parallel paths, one with a charge qubit, the other using a phase qubit. The formidable main goal is to experimentally reach the quantum ground state of a mechanical mode. I will investigate the following routes: Make a 1 GHz frequency NR, corresponding to 50 mK, which will reach the ground state at accessible temperatures. On the other hand, I propose to side-band cool a lower-frequency NR via the attached SC qubit. Near the quantum limit, I will start taking advantage of the NR as a building block of electromechanical quantum information. I also propose to push the QED setup of SC qubits coupled to electrical cavities towards more and more complicated states in order to test quantum mechanics in the nearly classical limit.",Electromechanical quantum coherent systems,FP7,12 July 2016,01 January 2010,1372999.99 NEMVOCS,Sabanci University * Sabancı Üniversitesi,information and communications technology,"The emerging field of nanotechnology offers clear prospects for next-generation chemical sensors. Nanoscopic devices, by the very nature of the size regime they exist in, possess enlarged surface-area-to-volume ratios as compared to their macroscopic counterparts. Therefore, if sensing is accomplished through a surface related process, such as surface adsorption or a surface chemical reaction, one naively expects a nanoscale sensor to enable enhanced sensitivity. In addition, most nanodevices require extremely low power and semiconductor nanodevices can be interfaced with enabling circuitry on the same chip. In short, integrating thousands, even millions of nanodevices on a single chip and realizing distributed sensing with ultrahigh sensitivity is within reach in the near future.The proposed project describes nanosensors for sensing a variety of volatile organic compounds (VOCs). VOCs are technologically and environmentally relevant compounds, such as aromatic hydrocarbons, halogenated hydrocarbons, and aliphatic hydrocarbons. The proposed nanosensors will be based upon nanoscale mechanical resonators – the so-called nanoelectromechanical systems (NEMS). With their high resonance frequencies, miniscule active masses and high quality factors, NEMS provide the ultimate platform for sensing applications; research in the past five years has clearly demonstrated the potential of NEMS-based sensing in the zeptogram level. Within the duration of this project, chemically functionalized NEMS sensors will be fabricated using standard semiconductor fabrication techniques. The fabricated NEMS sensors will be operated at room temperature to demonstrate sensing of important VOCs. The applicant, Dr. Kamil Ekinci, has been pursuing research in nanotechnology in the United States for the past decade and a half. If granted, the award will enable his reintegration to his home country, Turkey.",Ultrasensitive Volatile Organic Compound Sensors based upon Nanoelectromechanical Systems,FP6,31 May 2007,01 June 2007,80000.0 NENA,Aalto University * Aalto-yliopisto,energy,"The aim of this project is to develop advanced nano-structured materials and components for a new science- based production technology for the co-generation of chemicals and energy in a polymer electrolyte fuel cell reactor. It is expected that a significant increase in added value to chemical streams from the petrochemical industry will be achieved by harnessing the Gibbs free energy of electrosynthetic oxygen insertion reactions to low molecular weight alkenes. The project will utilise new nanoscale electrocatalytic materials for the simultaneous syntheses of chemicals and for energy production. Two examples are chosen for this application, oxygen reduction to yield hydrogen peroxide and double bond electrochemical epoxidation. The understanding of the mechanism of the first reaction is quite advanced, whereas that of the second has not yet been addressed. The research will establish links between surface structure and reactivity using recent advances in computational techniques for predicting the course of reactions at the surface of nanosized clusters. For this application, the electronic properties and reactivity of nanoparticles to be used as electrocatalysists will be investigated. The partnership includes a manufacturer of fuel cell reactor components, Johnson Matthey, since the long-term industrial application of this research lies in a new use of fuel cell reactors. This concept that has not been developed so far due to the lack of a basic understanding of the mechanism of many reactions where it could be employed. Thus, this project can open up the possibility of a new approach to industrial production of chemicals the synthesis of which involves changes in oxidation state.This aim, if achieved, will represent a major step change in the utilisation of an inherently clean technology.Importantly, new ideas for developing new anionic membranes and mesoscopic ion-exchangers will be explored. This will be an important activity in this project",Nanostructures for Energy and Chemicals Production,FP6,30 June 2007,01 July 2004,1777496.0 NEONANO,Aachen University Hospital * Universitätsklinikum Aachen,health,"The aim of my proposal is to establish 'Neoadjuvant Nanomedicines for vascular Normalization' (NeoNaNo) as a novel concept for improving the efficacy of combined modality anticancer therapy. This concept is radically different from all other drug targeting approaches evaluated to date, since nanomedicines are not used to directly improve drug delivery to tumors, but to normalize the tumor vasculature, and to thereby indirectly improve drug (and oxygen) delivery. The need for such an alternative concept can be exemplified by taking the (pre-) clinical performance of nanomedicines into account: whereas in animal models, they generally improve both the efficacy and the tolerability of chemotherapeutic drugs, in patients, they often only attenuate the toxicity of the intervention, and they fail to improve the efficacy of the drug. To overcome this shortcoming, I here propose to use corticosteroid-containing nanomedicines, targeted to tumor-associated macrophages (TAM), to inhibit pro-inflammatory and pro-angiogenic signaling by TAM, and to thereby homogenize the tumor vasculature, increase tumor perfusion and reduce the interstitial fluid pressure. As a result of this, the tumor accumulation, intratumoral distribution and antitumor efficacy of subsequently administered chemotherapeutics, as well as of radiotherapy (because of enhanced oxygen delivery) can be substantially improved. To achieve these goals, liposomal, polymeric and micellar corticosteroids, several different animal models, and several different imaging agents and techniques will be used to (I) visualize and optimize nanomedicine-mediated vascular normalization; to (II) potentiate chemotherapy; and to (III) potentiate radiotherapy. These efforts will not only provide a solid basis for a completely new paradigm in nanomedicine research, but they will also result in novel, broadly applicable and clinically highly relevant combination regimens for improving the treatment of advanced solid malignancies.",Neoadjuvant Nanomedicines for vascular Normalization,FP7,31 December 2017,01 January 2013,1356000.0 NEONUCLEI,University of Southampton,manufacturing,"NEONUCLEI will develop transcription-competent synthetic analogues of cell nuclei. These particles, termed neonuclei, will be obtained through self-assembly/organisation in mixtures of DNA, macromolecules (or nanoparticles), and lipids. The composition of the neonuclei will be chosen to produce particles with internal nano-architectures capable of sustaining gene transcription upon the addition of transcription factors. These design of the static architectures of the neonuclei and their dynamic properties will be guided by observations on real nuclei. The DNA of the neonuclei will contain a gene cluster (or tandem repeats of the same gene). The genes will be separated by sequences designed to induce DNA compaction in response to specific chemical or physical stimuli. This will be exploited to establish non-biological control over the transcription of parts, or all, of the DNA. These control sequences offer the opportunity for multiple transcription control strategies and provide the capability of implementing temporally co-ordinated synthesis of multiple gene products. Neonuclei represent a key enabling step in the realisation of semi-biotic systems; these are systems and devices that combine synthetic non-natural functional systems with systems of biological origin. The neonuclei will be integrated with biological systems, or with isolated components, to produce novel semi-biotic devices capable of the controlled in situ synthesis of complex bio-molecules on demand.",Self-assembly of synthetic nuclei: key modules for semibiotic chemosynthetic systems,FP6,31 January 2009,01 February 2005,1949000.0 NEREO,National Research Council * Consiglio Nazionale delle Ricerche (CNR),manufacturing,"NEreO addresses to the study and the development of nano-scale field-effect transistors (i.e. transistors with source-drain inter-electrodes distance varying from hundreds to few nanometers) based on organic molecular films. Organic materials are expected, in the near future, to give rise to a new generation of devices for electronics, photonics and optoelectronics, which will cause a paradigm shift in the production of electronic devices and pave the way for the era of plastic electronics. The main goals of NEreO will be achieved by the original combination of a sophisticated nano-scale fabrication method, namely e-beam lithography, with the unprecedented ability of the Supersonic Molecular Beam Epitaxy deposition technique to control morphology, structure and interfaces of organic films. Besides technological applications, nano-scale organic field-effect transistors will be basic tools for studying charge transport, charge injection and interfaces in organic materials. At Cornell, the fellow will benefit by the presence of several multicultural scientific communities built around national facilities such as the Cornell Nanoscale Science and Technology Facility, the Cornell Center for Materials Research and the Cornel High Energy Synchrotron Source. The fellow will thus attain levels of world-class excellence, satisfying the objectives of the Specific Programme, and acquire the professional independence required to realize the objectives of the Work Programme. The success of NEreO will rely on the multidisciplinary approach pursued together with the state-of-the-art facilities and methodologies adopted. The collaboration between two world-class leading experts will give the chance to Dr Cicoira to grow as a leading scientist with global thinking and ability to promote networks and common strategy for the creation of new facilities.",Nano-scale Electrical Properties of Organic Thin Films,FP6,31 August 2008,01 September 2005,0.0 NERVE-REPAIR,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"The proposed project aims to develop engineered biodegradable conducting 3D scaffolds capable of promoting neuronal survival, as well as axon extension and guidance, for treating peripheral nerve lesions. Current approaches focus on the sensitivity of neurons to the surrounding environment, which includes surface topography, biochemical cues, and electrical activity. Constructs implanted in vivo are also subject to mechanical constrains that have an impact on tissue formation. This project aims to investigate the influence of these mechanical stimulations on scaffolds and neuronal cells proliferation. Moreover, the mechanical constrains applied on engineered tissues inside the body will be evaluated with flexible biodegradable strain sensors developed for this purpose. Finally, scaffolds with various geometries designed to absorb the vibrations will be fabricated and evaluated. This project proposes an additional strategy that can be combined to other therapies to improve nerve regeneration. The first part of the project will be performed at Stanford University, USA, in the group of Organic and Carbon Nano Materials for Electronic Devices led by Prof. Z. Bao. Main tasks: literature search, produce the scaffolds, implement a measurement setup allowing mechanical stimulations of scaffolds in liquid, perform an in vitro degradation study on scaffolds, develop mechanical models, develop and characterize a biodegradable strain sensor. The second part of the project will be performed at EPFL, Switzerland, in the Laboratory for Soft Bioelectronic Interfaces led by Prof. S. Lacour. main tasks: Implement a mechanical stimulation setup in liquid based on existing setup in the lab, produce scaffolds, perform an in vitro study on scaffolds with neuronal cells and mechanical stimulation, perform an in vitro study on the strain sensor to verify its biocompatibility, design, fabricate, and assess the in vivo performances of scaffolds with new geometries.",Development of biodegradable conducting scaffolds for treating peripheral nerve lesions taking into account the influence of mechanical vibrations on neurons regeneration in tissue engineering,FP7,,,282542.0 NEST,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"Among today challenges that of energy needs is one of the most important. An obvious question is its production but the need of energy storage systems is almost as large. Renewable energies will not have an impact unless we find an efficient way to store the electricity that they produce. Energy should be available everywhere and at any time, this translates in a strong need for energy containers in the form of electrochemical storage. In this context, the NEST project aims to demonstrate and develop a new kind of integrated supercapacitors, electrochemical capacitors (ECs), as well as novel pseudocapacitors devices able to drastically enhance the energy storage capacity. The primary target of the project is to produce a micro-supercapacitor with integrated electrodes compatible with microelectronics process that can withstand solder reflow (280°C for few minutes). We will associate the high surface area of a new kind of silicon nanostructures, to the high thermal stability of ionic liquids used as the electrolyte. We propose to integrate Si nanowires with sub-nanostructures such as silicon branches and nano-diamond coatings. Diamond coating will bring the additional advantage to allow using protonic electrolyte while keeping a wide 2-3 V electrochemical window. In addition to the giant surface area provided by the nanotree design, even higher capacitance will be achieved by using redox-active coating such as metal oxides and electro-conducting polymers (ECPs). As a result, this combination will lead to highly reversible surface redox reaction with electrochemical double layer capacitance. These new devices well adapted to peak power demand and storage while improving energy capacity will enhance the energy efficiency and consequently will increase the competitiveness of Europe's industries.",Nanowires for Energy STorage,FP7,31 October 2015,01 November 2012,2356536.0 NET-GENESIS,University of Sussex,health,"The NET-GENESIS project aims to investigate how networks form, evolve and are configured when a new technology emerges. These networks include a number of interlinked actors (e.g. individuals, organisations, institutions) extending across multiple domains in which the rewards systems, incentives and power structures can differ markedly (open science vs. market-based). The architecture of the relationships among these actors may exert a significant influence in shaping technological change in certain directions rather than others, which in turn may have the potential to provide more socially optimal or desirable technological options. In this regard, a number of examples can be identified to highlight the importance of these networks for emerging technologies. For instance, networks can represent channels through which entrepreneurs and firms access to the financial resources (e.g. venture capitals) required pursuing R&D activities. In addition, the open-innovation framework has highlighted how networks are critical conduits for the exchange of knowledge, ideas, and resources among the different actors involved in the innovation process. Finally, networks extend also across science and technology domains thus stimulating scientific discoveries and supporting the development of novel technological applications. However, while the literature contributing to our understanding on how network variables affect actors' performance and behaviour is quite large, the genesis and dynamics of the networks surrounding emerging technologies remains a relatively unexplored area of research. The proposed project is a cutting-edge project that aims to contribute to filling this gap by conducting a comparative study (involving 6 case-studies) on the network micro-dynamics of emerging technologies across three industries, i.e. pharmaceuticals, biotechnology, and nanotechnology. To this end, a mixed qualitative-quantitative approach involving several levels of analysis will be adopted.",NET-GENESIS: Network Micro-Dynamics in Emerging Technologies,FP7,12 March 2016,13 March 2014,196682.0 NEURO-PLASMONICS,Istituto Italiano di Tecnologia (IIT),photonics,"Research neuronal signaling is the subject of a very large community, but progresses face a dense multi-scale dynamics involving signaling at the molecular, cellular and large neuronal network levels. Whereas the brain capabilities are most likely emerging from large neuronal networks, available electrophysiological methods limit our access to single cells and typically provides only a fragmented observation, on limited spatial/temporal scales. Therefore, broadening the spectrum of scales for observing neuronal signaling within large neuronal networks is a major challenge that can revolutionize our capability of studying the brain and its physio-pathological functions, as well as of deriving bio-inspired concepts to implement artificial system based on neuronal circuits. We propose the development of an innovative electro-plasmonic multifunctional platform that by combining different methodologies emerging from distant fields of Science and Technology will provide a radically new path for real time neurointerfacing at different scale levels: 1. The molecular scale: 3D plasmonic nanoantennas will give access to information at molecular level by means of enhanced spectroscopies with particular regard of time resolved Raman scattering. 2. The single-neuron scale within neuronal networks: by both in-cell and extra-cell couplings with 3D nanostructures which work at the same time as plasmonic antennas and CMOS 3D nanoelectrodes. 3. The scale of large neuronal networks: by CMOS high-density electrode arrays for spatially and temporally resolving neuronal signaling form thousands of measuring sites. This is achieved by exploiting an innovative nanofabrication method able to realize 3D nanostructures which can work at the same time as plasmonic nanoantennas and as nanoelectrodes. These structures will be integrated on CMOS multi-electrode arrays designed to manage multiscale measurements from the molecular level up to network level on several thousand of measurement sites.",Neuro-Plasmonics,FP7,31 March 2018,01 April 2014,1388000.0 NEUROCARE,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"NeuroCare aims to create better retinal, cortical and cochlear implantable devices through the use of improved interfacing between the electronic implants and living cells. The NeuroCare concept involves low-cost, carbon-based materials, well-adapted for medical implants, because they (i) offer wide range of electronic properties (metal, semiconductor and insulator), (ii) are bio-inert and (iii) are physically robust. Coupling between electronic devices and neurons was recently studied using 'soft', nanocrystalline diamond-based micro-electrode arrays, evaluated in laboratory animals for retinal stimulation. These diamond implants considerably reduced gliosis, enabled stimulation currents to be raised by more than one order of magnitude before causing visible chemical alteration, and enabled long lasting operation with reduced biofouling. Our previous experience with nanocrystalline diamond will be directly built upon through the introduction of atomic layers of graphene to diamond surfaces. NeuroCare will specifically focus on: • Carbon-biointerface development offering reduced biofouling over the state-of-the-art, as set by the DREAMS project and improved biocompatibility • Interfacing of rigid MEAs and FETs with cells and organs to improve bidirectional communication with neurons for in vitro research and pharmacological applications • Nanoscale surface engineering and flexible macroscale implant materials for optimal contact to biological tissue • Making and testing implantable MEAs and FETs for complex multichannel neuronal communication - targeting the specificity in vivo of the implantable devices for 3 high-impact clinical applications Neurocare partners will test interfaceable and implantable devices via in vitro and in vivo testing. NeuroCare federates 12 partners: CEA (LIST and CLINATEC), Ecole Supérieure d'Ingénieurs en Electronique, Forschungszentrum Jülich, Ayanda Biosystems SA, University College London (London Centre for Nanotechnology), Johannes",Neuronal NanoCarbon Interfacing Structures,FP7,28 February 2015,01 March 2012,3619985.0 NEUROMOLANATOMY,University Hospital Göttingen * Universitätsmedizin Göttingen,health,"The brain is nowadays the object of a number of extensive systematic studies that focus on seemingly all aspects of its morphology and function, from overall brain architecture to neuronal connections, neuronal morphology and gene expression. However, at least one basic aspect is as yet incompletely studied: the molecular anatomy of the neuron, i.e., the copy numbers and the spatial arrangement of molecules within the neuronal cell. This cannot be addressed by gene expression or proteomics approaches, as they do not have sufficient spatial precision. Electron microscopy, ideal for unraveling the neuronal morphology, does not have sufficient protein labeling efficiency. My project aims to fill this gap by a combination of super-resolution fluorescence microscopy, advanced fluorescence labelling techniques and advanced biochemistry tools such as quantitative mass spectometry. My objectives are fourfold: 1) to determine the molecular organization of at least 200 major neuronal proteins: their exact copy numbers and their position within the cell determined with nanoscale precision; 2) to generate a bank of biochemistry and microscopy sample preparations that will be available world-wide for the characterization of 1000-2000 additional proteins; 3) to integrate results into an in silico neuronal model that can be used for modelling functional neuronal parameters; 4) to use this technology to determine the changes in neuronal anatomy caused by neurodegeneration in Alzheimer's and Parkinson's Diseases. My group has already performed key preliminary work towards these aims. Our preliminary work focused on the synapse, where we ascertained copy numbers and positions for proteins adding up to more than 50% of the synapse's protein mass (see figure). We are thus ready to embark on this large-scale, risk-taking project. We are confident that the in silico neuron and the preparation bank we will create will represent key new resources for future studies in neurobiology.",The Molecular Anatomy of Neurons,FP7,31 March 2019,01 April 2014,1985062.0 NEURONANO,University College Dublin,health,"As the use of nanoparticles becomes more prevalent, it is clear that human exposure will inevitably increase. Considering the rapidly ageing European population and the resulting increase in the incidence of neurodegenerative diseases, there is an urgent need to address the risk presented by nanoparticles towards neurodegenerative diseases. It is believed that nanoparticles can pass through the blood-brain barrier. Once in the brain, nanoparticles have two potential major effects. They can induce oxidative activity (production of Reactive Oxygen Species), and can induce anomalous protein aggregation behaviour (fibrillation). There are multiple disease targets for the nanoparticles, including all of the known fibrillation diseases (e.g. Alzheimer's and Parkinson's diseases). The factors that determine which nanoparticles enter the brain are not known. Nanoparticle size, shape, rigidity and composition are considered important, and under physiological conditions, the nature of the adsorbed biomolecule corona (proteins, lipids etc.) determines the biological responses. The NeuroNano project will investigate the detailed mechanisms of nanoparticle passage through the blood-brain barrier using primary cell co-cultures and animal studies. Using nanoparticles that are shown to reach the brain, we will determine the mechanisms of ROS production and protein fibrillation, using state-of-the-art approaches such as redox proteomics and isolation/characterisation of the critical pre-fibrillar species. Animal models for Alzheimer's diseases will confirm the effects of the nanoparticles in vivo. At all stages the exact nature of the nanoparticle biomolecule corona will be determined. The result will be a risk-assessment framework for assessing the safety of nanoparticles towards neurodegenerative diseases, based on the connection of their biological effects to their biomolecule corona, which determines the biological response in vivo and reports on the nanoparticles' history.",Do nanoparticles induce neurodegenerative diseases? Understanding the origin of reactive oxidative species and protein aggregation and mis-folding phenomena in the presence of nanoparticles,FP7,31 January 2012,01 February 2009,2498000.0 NEURONANO,University of Trieste * Università degli studi di Trieste,health,"The NEURONANO network proposes to integrate carbon nanotubes (CNT) with multielectrode array (MEA) technology to develop new generation biochips to help repair damaged central nervous system (CNS) tissues. This objective will be reached by adopting a multi-disciplinary approach and by crossing the boundaries among Materials Science, Nano and Microtechnology, and Neuroscience. The impact of carbon nanotubes on multielectrode array (MEA) technology and therefore on neuro-implant technology represents a first step toward CNS nanoengineering. Our approach is to push ahead the application and functionalization of carbon nanotubes in the CNS by focusing on CNT chemistry, peptide and surface chemistry and two complex networks in cultures: the spinal cord (locomotor networks) and brain (hippocampus and neocortex networks). We will concentrate on the complex electrical activity of these networks once grown on implantable substrates. We are specifically interested in understanding how the components underlying electrical activity are organized when implemented with semi-conductive substrates, and how this organization changes in the presence of molecular cues or chronic stimulations. The research plan has three major aims: i) to answer fundamental questions about the biophysical interactions between nanomaterials and neurons ii) to exploit carbon nanotubes in the presentation of positive and negative cues, thus providing specific molecular environment to favor axonal regeneration and retargeting; iii) to develop the characterization of novel MEA/nanotube integrated devices, for multi-site extracellular stimulation and recording.",Towards new generations of neuro-implantable devices: engineering NEUROns/carbon NANOtubes integrated functional units,FP6,31 January 2010,01 August 2006,1799589.0 NEURONQ,Ben-Gurion University of the Negev,information and communications technology,"Brain research and quantum technology are at the focus of 21st century science. Although theoretical and experimental studies have provided some insights regarding the mechanisms of how the brain acquires, represents and stores information, a comprehensive theory of the brain and the underlying neural information processing is still missing. Experimental techniques to study brain processes on different levels of description, notably the sub-neuron (synaptic, dendritic and axonal), single neuron and neural network level, are therefore of fundamental importance for brain research. Recently, a new promising technique in solid state physics has emerged for measuring electric and magnetic fields at the nanometer scale with unprecedented spatiotemporal resolution (sub-micron and sub-ms range). The nitrogen-vacancy (NV) defect in diamond is a unique ultra-sensitive quantum device that can sense external magnetic and electrical fields via its spin states, which can be read-out optically using electron spin resonances. The NEURONQ project aims towards the development of an NV centre based neuroimaging system for real-time recording of neural activity on the sub-neuron, neuron and neuron network level under ambient conditions. The NEURONQ projects combines both disciplines, brain research and quantum technology, into an exciting multidisciplinary research effort by combining expertise from physicists, neuroscientists and nanoengineers. The NEURONQ project is expected to have impact of paramount importance for basic neuroscience research and neurotechnology, and thus, will significantly contribute to European scientific and technological competitiveness and excellency.",Quantum magnetic sensing of neurons using nitrogen-vacancy centers in diamond,FP7,05 July 2018,06 January 2014,256148.4 NEUROSCAFFOLDS,Advanced International School of Advanced Studies * Scuola Internazionale Superiore di Studi Avanzati,health,"Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent - neurite protrusion and the formation of neuronal network by using only nanopatterns. The present proposal is based on four main steps: i - Development and fabrication of Scaffolds; ii - Experimentation and testing of the formation of 3D neuronal networks; iii - Analysis of long term survival of 3D neuronal networks; iv- Development and testing of scaffolds for implants. The final and most important step concerns the implantation of our scaffolds in a neuronal tissue for repair. We will attempt to implant our scaffolds for repairing spinal cord and sciatic nerve injuries, a realistic but challenging aim. Controlled nanoscaled scaffolds will be obtained using nanocomposite materials to obtain custom-designed SFF scaffolds. These scaffolds will be constructed with different materials and will be decorated with appropriate CNTs and/or signaling molecules. Medical imaging will be used to target and interface personalized scaffold production for repair of injuries of the spinal cord and sciatic nerve. In order to achieve these results we have formed a collaboration based on two clusters of research centres, one in China and one in Europe. The cluster in China is composed of the Chinese Academy of Science in Bejing, the Institute of NanoTech and NanoBionics in Suzhou and the Department of Neurosurgery Neurology, Drum Tower Hospital, of the Nanjing University. The cluster in Europe is formed by SISSA in Trieste, the University of Trieste, IIT in Genova, Ecole Normale Supérieure (ENS) in Paris and the University of Lund in Sweden where the repair of the sciatic nerve and the spinal cord will be studied. These two clusters have all the expertise to tackle and reach our objectives.",Rapid prototyping scaffolds for the nervous system,FP7,30 June 2016,01 July 2013,1799788.0 NEUROSCREEN,University of Liège * Université de Liège,health,"The project aims to develop an integrated system allowing differential diagnosis of neurodegenerative diseases based on several patented, sensitive and robust technologies. This system uses an ultrasensitive detection of specific direct and indirect amyloid-related markers in the cerebrospinal fluid and in blood, with new derivative products of nano/micro biosciences. Among diseases with amyloid deposits, the NeuroScreen project will focus on Alzheimer and Prion diseases for which some ambiguities still exist regarding their differential diagnosis. At present, their diagnosis must be confirmed by post-mortem cerebral analysis. The experimental work is broken into 7 workpackages management being gathered in a WP0, with the corresponding objectives being achievable within the 36 months of the project: WP1 Design, optimisation and production of the early test; aim: neuroaptamer prototypes, neuro-strips, neuro-magnetic beads, validation of packaging and sterilization process, and stabilised and validated supports. WP2 Alzheimer Diagnostic: Tau-181 and -231 markers; aim: choice of the marker candidate and the prototype to be tested in a multiplex trial. WP3 Dementia diagnostic and Lewy bodies: -synuclein marker; aim: development and validation of a suitable assay for -synuclein oligomers. WP4 Creutzfeldt-Jakob: PRION; aim: validation of aptamers, neurostrips and i-PCR. WP5 Therapeutic follow-up; aim: biological markers for future therapeutic follow-up validation WP6 Integrative section and fundamental knowledge derived from the other WPs; aim: validation of the multiplex assays systems. WP7 Accompaniment and regulatory follow-up. The work will be carried out by a consortium made up of 12 partners, coming from 6 European member-states. A complementary expertise and a multidisciplinary partnership of high quality has been gathered with academics, research centres, 1 technology transfer center, 2 hospitals, 2 industrial SMEs and 1 SME expert in regulatory aspects.",Sensitive and differential blood and cerebrospinal fluid test for neurodegenerative dementia diagnosis,FP6,31 December 2009,01 January 2007,2797521.0 NEUROTAS,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The project aims to develop a prototype of a miniaturized system for diagnostics in the early stage of Alzheimer disease and other neurodegenerative diseases, or as a point-of-care instrument for patient follow-up. The system to be developed belongs to the emerging field of 'lab-on-chip¿ systems. It incorporates several innovative enabling technologies, including microfluidic flow control, highly sophisticated nanobiodevices with integrated detection, and novel magnetic nanoparticles. These approaches will lead to unprecedented integration and automation, and allow routine implementation of tests that can presently only be performed in a small number of specialized research laboratories. The system will use biomarkers present in blood, such as differently cleaved b amyloid peptides and post-translational modifications of the Tau protein. The miniaturization and integration of innovative detection technologies will greatly extend the sensitivity of biomarker detection, and thus improve the precocity of diagnosis. This is of paramount importance for the treatment of neurodegenerative diseases, since therapeutic approaches able to retard the evolution of the diseases are progressing and promising, but little hope exists for the repair of existing brain damage. The method will also allow the simultaneous study of a wide range of markers, improving the early discrimination between different neurodegenerative diseases, and thus the choice of treatment. Indeed, the NeuroTAS system will have a modular and evolutive structure, and it will be able to progressively test and integrate into its diagnostic scheme new biomarkers that may be discovered during the prototype development. The consortium is a combination of 4 academic, methodology-oriented laboratories with complementary competences in biochemistry, analytical chemistry, biophysics and microfabrication, two SMEs in the field of microfluidics, and two ¿end-users¿ directly involved in patient diagnosis and treatment.",Microfluidic Total Analysis System for the Early Diagnostic of Neurodegenerative Disorders,FP6,30 June 2010,01 January 2007,2499999.0 NEUROTRAF,Universiteit Utrecht * Utrecht University,health,"Activity-dependent modulation of synapses is the core mechanism of synaptic plasticity and underlies learning and memory processes in the brain. Understanding dynamic changes at synapses requires a deeper insight in the molecular machinery involved in the transport and trafficking of postsynaptic proteins. Recent studies suggest that the cytoskeleton (microtubule and actin) and molecular motors (kinesin, dynein and myosin) play an essential role in the targeting and delivery of cargos to synapses. Moreover, it has been shown that defects in synaptic cargo transport are common feature of many human neurodegenerative and psychiatric diseases. One of the limiting factors to study synaptic cargo trafficking in living neurons is the lack of appropriate molecular and imaging tools. Recent developments in super-resolution microscopy as well as the progress made in nanotechnology yield many new possibilities to study synaptic trafficking processes in neurons. In this proposal, we will address key issues in synapto-dendritic protein transport by developing novel molecular tools and imaging systems in living neurons. These tools will be utilized to answer a number of fundamental questions: 1) What is the contribution of specific motor proteins to dendritic transport? 2) Do microtubule motors enter dendritic spines and transport cargos in and out? 3) What is the mechanism of cargo movement between neighboring spines? The expected outcomes of this project will contribute fundamental insights into trafficking processes in neurons and deepen our understanding of the molecular dynamics of synapses.",Molecular mechanisms of synapto-dendritic cargo trafficking,FP7,31 March 2015,01 April 2013,183805.0 NEUTRAL,Weizmann Institute of Science,energy,"I propose to study 'neutral excitations' in 2d and 1d electronic systems. Such excitations, rarely studied, are unique since they are chargeless but may carry energy. Being byproducts of electron interaction, they come in a few flavors: (i) Downstream modes in composite edge channels of the integer quantum Hall effect (IQHE) regime; (ii) Upstream modes in the fractional quantum Hall effect (FQHE) regime; and (iii) Zero energy Majorana states (localized or propagating quasi-particles), in non-abelian FQHE states and in 1d topological P-wave superconductors. My main interests in neutral modes in the QHE regime are: (a) Their direct association with the nature of the wavefunction of the quantum state; (b) Being excited when a charge mode is being partitioned (say, by a quantum point contact), they may play a prime role in dephasing interference of quasi-particles due to the energy they rob (in the partitioning process). As for detecting Majorana quasi-particles, and aside from the exciting physics, their non-abelian nature makes them attractive as building blocks in 'decoherence resistant' systems. Based on our acquired abilities, such as material growth, processing techniques, and sensitive measurement techniques, I plan to perform experiments, which include: thorough studies of downstream and upstream neutral modes via shot noise and thermoelectric current measurements; proving (or disproving) their involvement in dephasing fractionally charged quasi-particles; growing and processing structures that harbor Majorana states (in 1d nano-wires and in 2d FQHE regime; and, possibly, eventually, manipulate Majorana states (by coupling and braiding). Experiments will employ, e.g., ultra-low temperatures, sensitive shot noise measurements, cross-correlation of current fluctuations, and interference of quasi-particles (charge and neutral) in novel interferometers.",Neutral Quasi-Particles in Mesoscopic Physics,FP7,28 February 2019,01 March 2014,2428042.0 NEW ED,RWTH Aachen University of Applied Sciences * Rheinisch-Westfälische Technische Hochschule Aachen,environment,"NEW ED aims at closing industrial water cycles and reducing the amount of waste water streams with highly concentrated salt loads stemming from a broad range of industrial production processes by exploiting the waste components (salts) and transforming them to valuable products. This will be achieved by developing new micro- to nano-porous bipolar membranes for bipolar electrodialysis (BPMED), a new membrane module concept and by integrating this new technology into relevant production processes. The bipolar membrane process produces acids and bases from their corresponding salts by dissociating water at the interface within the bipolar membranes. However, BPMED so far has been applied only in niche markets due to limitations of the current state of membrane and process development. Major drawbacks of the classic BPMED process are low product purity, limited current density and formation of metal hydroxides at or in the bipolar membrane. The objective of this project is to overcome these limitations by developing a new bipolar membrane and membrane module with active, i.e. convective instead of diffusive water transport to the transition layer of the bipolar membranes, where water dissociation takes place. The key feature of the innovative new bipolar membranes is a nano- to micro-porous and at the same time ion conducting intermediate transition layer, through which water is convectively transported from the side into the transition layer. The porous transition layer may have either the character of a cation or an anion exchanger. Several promising intermediate layer materials together with different monopolar ion-exchange layers will be tested and characterized. Membrane manufacturing and new module concepts will be investigated to exploit the full potential of the new bipolar membrane technique. Integration of the developed membranes and modules into relevant production processes is an essential part of the project.",Advanced bipolar membrane processes for remediation of highly saline waste water streams,FP7,11 June 2014,06 January 2009,1163159.0 NEWEPOXY,IMDEA Materials Institute * Instituto IMDEA Materiales,information and communications technology,"Epoxy resins find versatile and massive use in such areas as coatings, adhesives, composite materials and electronic packaging, owing to their outstanding properties and favorable processability. However, they still suffer from high flammability. Furthermore, suppressing smoke release from burning of epoxy materials is quite challenging and far away from being well resolved. In this proposal we intent to develop a new generation halogen-free high-performance epoxy nanocomposites characterized by high fire retardant efficiency and low smoke release with satisfactory mechanical, thermal and other properties. First we shall design and prepare several novel graphene oxide/layered double hydroxide (GO/LDH) hybrids as multifunctional reactive fire retardants for epoxy resins, by wisely integrating LDH, GO and organic phosphorus into one component via a more sophisticated and innovative approach. Then these hybrids will be dispersed into an epoxy/hardener matrix at a nanoscale to yield the GO/LDH/epoxy nanocomposites. The curing reaction, reaction kinetics, mechanisms and rheological performance of these nanocomposites will be highlighted based on thermal and rheological analyses to reach a deep insight into how to optimize curing and processing conditions. The fire retardancy, smoke release, and mechanisms of the cured nanocomposites will be studied using cone calorimeter, TGA, UL94 and LOI tests, SEM, XPS, etc. The mechanical, thermal and other properties of the nanocomposites will be systematically examined. Eventually the structure-property relationship of these nanocomposites will be established. Predictedly, these epoxy nanocomposites will have not only much enhanced flame retardancy and lowered smoke release but also satisfactory mechanical, thermal and other properties. Our study will pave a new way of design, preparation and applications of GO/LDH-based high efficient, multifunctional flame retardants in the field of high-performance epoxy nanocomposites.",New Generation High-performance Fire Retardant Epoxy Nanocomposites: Structure-Property Relationship,FP7,03 July 2018,04 January 2014,230036.6 NEWEXTLIFESCAFF,University of Extremadura * Universidad de Extremadura,health,"Musculo-skeletal conditions are the most common causes of severe long-term pain and physical disability, affecting hundreds of million of people across the world and with a cost to society that Swedish health economists have calculated to be by far the highest, even compared to brain and mental diseases added together. Therefore, the demand for biomaterials to replace bone functions and improve quality of life is rapidly increasing. Today’s implants have a variety of shortcomings related to their fixation, and, unlike natural bone, cannot self-repair or adapt to changing physiological conditions. Thus, an ideal solution, and a scientific research challenge, is to develop bone-like biomaterials that will be treated by the host as normal tissue matrices and induce cell penetration and proliferation after implantation while their mechanical properties match those of the tissue to be repaired (low density, low stiffness, and high strength). The proposed work is focused on the development and evaluation of novel adaptive dense inorganic-organic composite biomaterials with features controlled down to the nano-level that will combine optimum mechanical properties with different degrees of controlled resorbability. In a step-by-step approach, a wide spectrum of materials with different organic components and microstructural architecture will be fabricated by infiltrating inorganic porous scaffolds with different resorbable polymers. These dense materials will have better mechanical properties than porous ceramic scaffolds alone. Also, during their biodegradation, there will be a programmed unmasking of different micro-architectures, chemical patterns, and porosities, in order to promote bone ingrowth while maintaining the mechanical stability of the implant-tissue interface. The proposed study will therefore allow one to design and optimize new bone implants with improved osteointegration and long-term mechanical integrity.",Development of Extended-Lifetime Organic-Inorganic Scaffolds for Orthopaedical Applications,FP6,31 August 2006,01 March 2005,127594.0 NEWGENSMM,University of Manchester,information and communications technology,"This Fellowship will seek to create a new generation of 'single molecule magnets' (SMMs), i.e. molecules that retain magnetisation in the absence of a magnetic field. SMMs may have long term applications in information storage of quantum computing. The key target is to raise the energy barrier to reorientation of magnetisation. It is believed the best method for so doing is to raise the anisotropic ions. Previous SMMs have involved Mn(III), Fe(III) and Ni(II); other ions present greater single ion anisotropy, and this Fellowship will target these ions. Specifically, V(III) and Fe(II) have useful characteristics for preparing high temperature SMMs. To use such ions requires careful exclusion of air in preparations, as they are highly sensitive to oxidation. Dr Przybylak (SWP) has great experience of handling air- and moisture-sensitive complexes, and he will bring his expertise to bear on this new field. The scientific goals are to prepare SMMs with higher blocking temperatures than those previously reported. In addition to the scientific goals, there are three training goals. Firstly, to provide SWP with training in X-ray single crystal diffraction methods. Secondly, to provide SWP with training in multi-frequency EPR spectroscopy, as applied to high spin cage complexes and SMMs. Thirdly, to provide training in key skills, including presentation of work in English, time management and career development. The third goal is to establish a working relationship between a leading UK research group, and a promising young Polish scientist.",DESIGN OF A NEW GENERATION OF SINGLE MOLECULE MAGNETS,FP6,31 January 2006,01 February 2004,168232.0 NEWIRES,Lund University * Lunds Universitet,information and communications technology,"Semiconductor nanowires composed of III-V materials have enormous potential to add new functionality to electronics and optical applications. However, integration of these promising structures into applications is severely limited by the current near-universal reliance on gold nanoparticles as seeds for nanowire fabrication. Although highly controlled fabrication is achieved, this metal is entirely incompatible with the Si-based electronics industry. It also presents limitations for the extension of nanowire research towards novel materials not existing in bulk. To date, exploration of alternatives has been limited to selective-area and self-seeded processes, both of which have major limitations in terms of size and morphology control, potential to combine materials, and crystal structure tuning. There is also very little understanding of precisely why gold has proven so successful for nanowire growth, and which alternatives may yield comparable or better results. The aim of this project will be to explore alternative nanoparticle seed materials to go beyond the use of gold in III-V nanowire fabrication. This will be achieved using a unique and recently developed capability for aerosol-phase fabrication of highly controlled nanoparticles directly integrated with conventional nanowire fabrication equipment. The primary goal will be to deepen the understanding of the nanowire fabrication process, and the specific advantages (and limitations) of gold as a seed material, in order to develop and optimize alternatives. The use of a wide variety of seed particle materials in nanowire fabrication will greatly broaden the variety of novel structures that can be fabricated. The results will also transform the nanowire fabrication research field, in order to develop important connections between nanowire research and the semiconductor industry, and to greatly improve the viability of nanowire integration into future devices.",Next Generation Semiconductor Nanowires,FP7,08 July 2020,09 January 2013,1496245.8 NEWLED,Aston University,transport,"NEWLED will develop high efficiency and high brightness monolithic and hybrid all-semiconductor WHITE light-emitting GaN-based diodes. Power losses due to phosphor conversion and the problem of different ageing rates of the GaN LED pump will be eliminated by the development of phosphor free structures with increased brightness (power emitted per surface per angle). NEWLED will enhance the efficiency of yellow InGaAlP/AlGaAs LEDs by bandgap engineered superlattices. Novel light extraction approaches will target advanced directionality and colour adjustment. Values of 50 to 60% overall efficiency with a conversion of greater than 200 lm/W in the exploited warm white LEDs are targeted as well as the realisation of a colour rendering index (CRI) of greater than 95. Advanced packaging will enable effective heat dissipation and light management. The devices will have immediate applications in automotive, industrial lighting and displays industries. Widespread implementation would reduce global energy consumption by approximately 10% and reduce CO2 emissions by 3Bn tonnes with consequent economic and environmental benefits.",Nanostructured Efficient White LEDs based on short-period superlattices and quantum dots,FP7,10 July 2018,11 January 2012,8400000.0 NEWMATCR,Leibniz Institute for Solid State and Materials Research Dresden * Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden eV,information and communications technology,"The search for new materials as an alternative to Si-based technology has been at the forefront of research in contemporary solid state physics and chemistry. One interesting route of overcoming the restrictions of conventional electronics is to make use of the spin to transfer information. A perquisite for this is the use of materials with full spin polarization of the conduction electrons such as the half metallic room temperature ferromagnet CrO2. We propose an investigation of high purity samples of CrO2 which have been recently synthesized using a novel route. These samples with a hitherto unexplored crystallographic and magnetic microstructure exhibit a host of interesting properties, together with the first observation of finite room temperature magnetoresistance (MR). We have also prepared some new CrO2 based composites which exhibit significant enhancement in MR and thus can be used as potential candidates for spintronic devices. Since this technique opens a new way to tailor MR by introducing new types of grain boundaries in any desired mass fraction, this provides a way to optimize parameters for spintronic properties of CrO2 based materials. We intend to study the effect of variation of the grain size and grain boundary density, in particular the role of antiferromagnetic nature of the grain boundary in magnetotransport. Besides magnetic and transport measurements in ultra high fields up to 60 Tesla, we propose to use a variety of complementary techniques such as specific heat in magnetic field, Hall effect, thermopower and electron spin resonance. Better understanding of the underlying physics from the analysis of data obtained from these experiments will enable us to optimize parameters for a practical room temperature spintronic device based on CrO2. Finally, fabrication of thin films and magnetic tunnel junctions using granular CrO2 in an appropriate microstructure based on the knowledge gained from studies on bulk CrO2 is envisaged.",Synthesis of new materials based on half metallic ferromagnet CrO2 and optimization of its properties for spin-electronics,FP6,17 October 2008,18 October 2006,213522.02 NEWMATS,University of Cambridge,energy,"The proposed work is in the field of inorganic-organic hybrid materials, focusing mainly on dense rather than nanoporous materials. There are a huge number of opportunities in this area, especially now that is has become relatively straightforward to control the conditions under which dense, often anhydrous phases with excellent thermal stability can be synthesized. The latter have a wide range of interesting properties in terms of optics, magnetism, electronic conductivity, catalysis and so on. We shall work on such functional hybrid materials with potential applications in areas such as lighting and displays, photovoltaic cells, data storage, ferroelectrics, catalysis, and gas storage. We shall also explore some of the fundamental questions concerning hybrid frameworks: What factors control their crystalline structures? Can we reliably simulate their structures and calculate their energies? What kinds of defects can be incorporated into hybrid frameworks? How do these affect their properties? What factors influence the mechanical properties of hybrid frameworks? Can we develop a general method for preparing nanoparticles of hybrids? The work will involve a great deal of solution-based synthesis, chemical and thermal analysis, structure determination by single crystal X-ray methods, physical property measurements (mainly optical, magnetic, electronic, and mechanical), computer simulations, and some calorimetry. Most of the facilities needed for this work are available in Cambridge, though I shall collaborate with others where appropriate (e.g. computer simulation, calorimetry).",New Directions in Hybrid Inorganic-Organic Framework Materials,FP7,30 April 2014,01 November 2008,2018579.0 NEWMET,University of California,photonics,"'The aim of this project is to optimize the design and growth conditions of self-assembled semiconductor nanostructures with applications in micro- and opto- electronics. With this purpose, the candidate is going to develop a systematic methodology of analysis based in electron beam techniques and apply it for the study of these systems. The control on the structural features of semiconductor materials is essential for further technological developments, with high relevance for many aspects of our current society. In particular, the fabrication of structures with a high density of homogeneously sized self-assembled nano-motives is one of the challenges in this field because it supposes the achievement of laser emission with high intensity and mono-chromaticity. This project addresses absolutely one of the main thematic areas of the European Research Area of the FP6 (“Nanothecnology and Nano-science) and is highly related to other one (“Information society technologiesâ€). The innovative character of this proposal stems from the use of techniques with atomic column resolution such as high angle annular dark field scanning transmission electron microscopy (HAADF-STEM) for the optimization of the microstructure of semiconductor self-assembled systems. The researcher in charge in UC-Davis is a world reference of leadership in the use of HAADF-STEM for structural analyses, and UCA has recently acquired the required equipment for this type of analyses. Therefore, this fellowship will provide the applicant with high level skills in HAADF-STEM, which will be transferred to UCA in the third year, fulfilling the objectives of the “Outgoing International Fellowshipâ€. The applicant has enough background knowledge both in semiconductor structures and in electron beam techniques to achieve the main objectives of the project. This stay abroad will provide her professional maturity and an expertise level in her scientific field, fundamental to develop an independent resear",New methodology for the characterization of semiconductor self-assembled nanostructures with optoelectronic applications,FP6,31 March 2009,01 April 2006,244368.97 NEWQDS,University of Glasgow,information and communications technology,"This project will investigate a diverse range of octanuclear zinc sulfide nanoclusters as Quantum Dots (QDs). Compared with colloidal QDs whose distribution are random over space, these stoichiometric crystalline nanoclusters exhibit uniform cluster size and long-range periodic ordering which are vital for the study of quantum confinement effects. A simple and successful scheme to assemble them has been reported by the applicant and the goal of this project is to further assemble and functionalize this system, explore their fascinating optical properties and create a new research frontier in biological applications.",New Frontiers in Quantum Dots Science: Assembly and Functionalisation,FP7,02 April 2015,03 January 2011,241289.6 NEWTON,LZH Laser Zentrum Hannover eV,photonics,"Photonic crystals and photonic band gaps (PBG) represent a new class of optical devices for guiding and processing light. Conventional optic relies on effects like reflection (mirrors, Bragg reflection), refraction (lenses, prisms) or diffraction (gratings). In PBG devices the interaction of light is based on 'optical bandgaps' in crystals, suppressing certain wavelengths to propagate in pre-determined directions. With the implementation of photonic band gaps in optical systems, new applications for processing light are feasible, existing optical functions can be build up with much smaller dimensions (< 1 mm³), and higher integration density can be achieved. In this project, a material and process technology will be developed which allows the fast and flexible production of real 3-dimensional photonic crystals. Only as 3-dimensional systems, PBGs can exploit their full theoretical capabilities. The manufacturing approach will be achieved by the combination of research activities on (i) polymer based nano-scale colloids, (ii) holographic structured polymers, (iii) laser based defect inscribing into the material with nm-resolution, (iv) infiltration and inversion techniques to realise photonic crystals, and the (v) full characterisation and performance evaluation of the manufactured components. In parallel, (vi) simulation and design tools for of PBGs will be improved and adapted to the manufacturing technology for a fast realisation of the devices and better understanding of influencing factors in the manufacturing process. First test devices will include basic optical functions like wave guides, splitters, filters for telecom applications. On the long term, this technology will contribute to optical integrated circuits and self routing in meshed communication networks. At this stage it can be anticipated that photonic crystals are essential for future all-optical computing, having the same impact in optical engineering as semiconductors and CMOS had in electronics","Enabling Technologies for 3D Nano Photonics: New Materials and Process Technology for Real 3D Integrated Optical Circuits, Photonic Band Gap Devices and Photonic Crystals",FP6,31 December 2008,01 January 2006,1976638.0 NEXT,University of Brighton,health,"Diabetes is caused by insufficient or lack of insulin secretion by the specialized B cells of the pancreas and, if not treated adequately evolves into in complications which alter patients integrity and wellness. Treatment is based on lifetime drugs administration for blood glucose control or parenteral infusion of insulin to better control glucose levels and glycosylation of hemoglobin. Artificial pancreases are in development but still dependent by external energy sources and need permanent transcutaneous access to release the hormone. Pancreatic whole organ transplantation is a major intervention requiring selected recipient and matched cadaveric donor which keep numbers down. Islet of Langerhans transplantation is a non-invasive method for the treatment of type 1 diabetes but several questions remain and several issues have to be addressed in order to improve the method since islet engraftment is clearly suboptimal, as a result of pro-apoptotic and pro-inflammatory stimuli sustained during islet isolation and at the site of implantation, the long-term islet graft function drops to 15% with time, and the current systemic immunosuppressive regimen has several drawbacks in terms of side effects. Solution should be find to increase transplantation efficiency with an higher number of islet, eventually from animals, induce tolerance toward the graft, avoiding systemic, lifetime immunosuppression and, lowering a specific inflammatory reaction and enhancing graft micro vasculogenesis to improve islet nesting. NEXT provides a 360° solution to the pitfalls of current methodology for pancreatic islet transplantation: i) Nano technologies, to engineer donor cell surfaces in order to derange recognition and suppress their rejection; ii) Advanced tissue engineering methods, to assemble bio synthetic islet, enriched by chimeric microvasculature; iii) Innovative double immune-suppressive strategy by graft - bound immunosuppressive nano peptides and shielded by self- vasculature","Nano Engineering for Cross Tolerance: new approach for bioengineered, vascularised, chimeric islet transplantation in non-immunosuppressed hosts.",FP7,30 September 2017,01 October 2013,4806416.0 NEXT-GEN-CAT,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),transport,"The main objective of NEXTGENCAT proposal is the development of novel eco-friendly nano-structured automotive catalysts utilizing transition metal nanoparticles (Cu, Ni, Co Zn, Fe etc) that can partially or completely replace the PGMs. Based on nanotechnology, low cost nanoparticles will be incorporated into different substrates, including advanced ceramics (SiO2, perovskite etc) and silicon carbides, for the development of efficient and inexpensive catalysts. The main idea of the proposal is the effective dispersion and the controllable size of the metal nanoparticles into the substrate that will lead to improved performance. To this end a modified polyol process as well as chemical and physical treatment of selected substances will enable the introduction of transition metal nanoparticles on the catalyst substrate precursors via adsorption and ion-exchange. The presence of metal ions sorbed on fixed precursor sites will inhibit the agglomeration during heating and final products with very fine particle dispersion and tuneable metal content will be obtained. It is expected that the developed catalysts will exhibit increased catalytic performance, even at low temperatures (200-250oC). Other key properties of the proposed nanostructured catalysts include: increased thermal stability (avoiding aggregation), improved durability, capability of reuse and recovery of transition metals as well as low health and environmental impact.",Development of NEXT GENeration cost efficient automotive CATalysts,FP7,01 July 2018,02 January 2012,0.0 NEXTDOT,University College Cork,information and communications technology,"The proposal will lead to significant advances in the general area of QD research. Improving the understanding of current QD materials and devices is crucial towards enabling this technology to reach its full potential. This understanding will emerge from the extensive experimental program foreseen, which includes detailed gain and refractive index measurements as a function of temperature from 77K to above room temperature, femto-second pump probe spectroscopy to determine the fundamental timescales of these novel structures and careful analysis of the efficiency and transport properties of these devices to reveal their fundamental transport and loss processes. This information will greatly aid the development of new quantum dot material structures such as those based on Antimonide substrates and dot-in-a-dot structures. These materials will be the first of their kind in the world and the researchers role will be key in providing feedback to both fabricators and designers. Through this interaction, great progress will be made in the practical realisation of the great benefits of quantum dot materials and their extension to new wavelength ranges.",Next Generation Quantum Dot Materials and Devices,FP6,31 May 2009,01 June 2007,212681.03 NEXTDX,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,health,"A spearhead function that lies within the promise of MNBS technologies is the rapid and sensitive detection of biomarker molecules in raw biological samples. However, it has been very difficult to realize the promise due to two key challenges: the signal-over-background challenge, i.e. many biomarkers have very low concentrations and real-life biological samples generate very high background signals, and the integration challenge, i.e. it is very difficult to conceive a system that has a very high performance and is still fully integrated, miniaturized, and cost-effective. NextDx will address these challenges by investigating an integrated system for protein biomarker detection with single molecule resolution. The system is based on magnetic nanoparticles that are controlled by electromagnetic fields and detected with nanometer precision in an integrated optical chip with bio-engineered surface. The system will allow a sharp biophysical discrimination between biomarker-induced and non-biomarker-induced nanoparticle binding signals, so as to approach the fundamental limit of counting statistics in real biological samples. This is a unique, novel, and timely approach. At the end of NextDx, we will demonstrate an integrated MNBS platform technology for extremely sensitive protein detection, within a few minutes, directly in blood plasma. The technology will be suitable for multiple biomarker testing outside the hospital, to improve for example the lives of chronically ill patients. NextDx is a unique international consortium with best-in-class partners contributing complementary physical and biomolecular engineering expertise, supported by an advisory board with all relevant stakeholders (clinicians, patient organisation, insurance company, regulatory agency). Together, all are focused on generating new insights in MNBS integration and on effective industrial-academic collaboration on the European scale towards next-generation integrated diagnostics.",Next-generation integrated MNBS-platform for instant diagnostics with single-molecule resolution,FP7,30 November 2015,01 December 2012,3608000.0 NEXTEC,Royal Institute of Technology * Kungliga Tekniska Högskolan,energy,"Global energy uncertainty and the limited recourses coupled with increased energy needs fuels the search for improving the efficiency of energy conversion technologies. Although the EU policies target increased use of renewable energy to 12% of gross energy production by 2010, this commitment has also highlighted the urgent need for improving the energy utilization of fossil-fuel based power-plants to allow continuation of the energy intensive lifestyle of EU countries. Thermoelectric (TE) devices can play a very important role in efficient energy harvesting, and recovery. TE devices are 'fuel-free' solid-state devices with no moving parts and therefore are extremely reliable. TEs can harvest residual low-grade energy which otherwise is wasted. To date, their use is limited by low conversion efficiency. The key factor for improving the performance of TE applications is mainly through the development of TE materials as well as corresponding TE module/device technology and design, based on the material types, which can ensure better performance. Recent advances in nanotechnology offer unprecedented opportunities in designing and fabricating increasingly complex material architectures with controlled and hierarchical microstructures. Theoretical predictions showed that low-dimensional TE materials with figure of merits (a measure of the goodness of TE materials) can be spectacularly enhanced from currently ~1 to extremely high values of 5 -10 (up to 20). The present proposal is concerned with applying modern nanotechnology principles to the design and creation of novel material architectures with enhanced TE properties, with close feedback with theoretical studies. The material architectures considered in this proposal are chosen based on suitability for the development of next generation TE modules and devices, designed for a few specific promising applications including harvesting waste energy from automobiles and environmentally benign, efficient cooling systems",Next Generation Nano-engineered Thermoelectric Converters - from concept to industrial validation,FP7,31 May 2014,01 June 2011,3931929.0 NF-RAD,Ozyegin University * Özyeğin Üniversitesi,manufacturing,,NF-RAD: Near-Field Radiation,FP7,04 June 2014,05 January 2009,0.0 NFESEC,University of Cambridge,photonics,"Photoelectrochemical H2 production from water is a field of high present interest. This project is to design nanophotonics for efficient solar-to-H2 energy conversion. A method will be developed for fabricating nanophotonic structure (such as inverse opal photonic crystals, nanoarray photonic structure) of narrow band gap ternary metal oxide as photoanodes, for example, BiVO4 (2.4 eV), InVO4 (2.0 eV), BiFeO3 (2.2 eV), etc. Highly efficient solar-to-H2 energy conversion is expected to be achieved due to the superiorities of the structure and unique optical properties of nanophotonic structures, including stronger interaction between light and the photoelectrode induced by the stop-band edge effect, greatly improved light harvesting due to the multiple scattering effect, efficient photogenerated charge carriers separation due to the distance for photogenerated holes to reach the interface of semiconductor and the electrolyte can be significantly reduced. The proposed project will try to address how nanophotonic structures with their unique physical properties can enable efficient harvesting of light.",Nanophotonics for Efficient Solar-to-H2 Energy Conversion,FP7,31 July 2014,01 August 2012,209033.0 NFRP,IMDEA Materials Institute * Instituto IMDEA Materiales,transport,"Fiber-reinforced polymers (FRP's), stronger per unit of weight than steel or aluminium, are highly demanded for high-performance applications. The use of FRP's in aerospace structures can lead to a significant reduction of maintenance costs, carbon imprint by fuel consumptions, COx and NOx emissions, etc. This is the reason why the last civil Airbus aircraft contains up to 52% in weight of composite materials and the Boeing 787 Dreamliner claims to be the first aircraft with a fully composite fuselage. However, composites materials presents several drawbacks that need to be overcome to fully take advantage of their excellent mechanical properties. From a mechanical perspective, aerospace composites are made of carbon fiber “plies” which are held together by a polymer. This polymer can crack easily, which results in the delamination of the plies and the failure of the structure if it is not detected on time. It is also required for aerospace materials to be protected from common environmental occurrences, such as lightning strikes, electromagnetic interferences, electrostatic discharge, etc. Various methods are used to address these concerns, such as the use of metallic meshes or foils. However, these meshes/screens are difficult to handle for both production and repairs, and increase significantly the overall weight of the aircraft. Here, I propose to develop a novel nano-architecture to enhance the mechanical and electrical properties of the composite in the through-the-thickness direction. This nano-architecture will also act as a sensing system, enabling damage detection and localization by resistive-heating based non-destructive evaluation. In summary, the nano-engineered composite proposed here is an intrinsically multifunctional material, with expected over the state-of-the-art mechanical and multifunctional properties.",Nano-Engineered Fiber-Reinforced Polymers,FP7,03 July 2019,04 January 2013,100000.0 NGCPV,Technical University of Madrid * Universidad Politécnica de Madrid,energy,"The Project, through a collaborative research between seven European and nine Japanese leading research centers in the field of concentration photovoltaics (CPV), pursues the improvement of present concentrator cell, module and system efficiency. Particular effort will be devoted to the development of multijunction solar cells (by researching on metamorphic, lattice match, inverted and bifacial growth, use of silicon substrates and incorporation of quantum nanostructures) with the objective of approaching the 50 % efficiency goal at cell level and 35% at module level (by incorporating advanced optics as for example Fresnel-Kohler concentrators). As a means to speed up the progress, the Project will also expand the use of characterization techniques suitable for CPV materials, cells, trackers, modules and systems by developing new ones, incorporating advanced semiconductor techniques to the field of photovoltaics (such as three dimensional real-time reciprocal space mapping, 3D-RTSM, piezoelectric photo-thermal and optical time resolved techniques) and by deploying a round robin scheme that allows the qualification and standardization of the results derived from the measurements. To support all these studies from a global perspective and, in particular, to ensure an accurate forecast of the energy produced at system level, the Project plans to build a 50 kW concentrator plant. To achieve its goals, the Project is structured into five RTD workpackages: new materials and device characterization, development of novel device technologies and quantum nanostructures for CPV, development of advanced CPV cells, development of characterization tools for CPV cells, modules and systems and development of CPV modules and systems. To strength the collaboration between EU and Japan, the Proposal also foresees more than 20 interchange visits. NGCPV is an EU coordinated project in the framework of call FP7-ENERGY-2011-JAPAN, forseeing a simultaneous start with the Japanese coordinated project. Accordingly, the Japanese project should start at the latest within 3 months of the signature of the EU grant agreement.","A new generation of concentrator photovoltaic cells, modules and systems",FP7,30 November 2014,01 June 2011,4999998.0 NIKER,University of Padua * Università degli Studi di Padova,health,"The project tackles the problem of earthquake-impact on Cultural Heritage assets starting from basic consideration that efficient protection, with substantial guarantee of compatibility and low-intrusivity, can only be achieved with 'minimum intervention' approach. This requires that potentialities of existing materials and components are as much as possible exploited in terms of strength and energy dissipation, and candidate interventions are validated and optimized on specific, real application conditions. At the project start, earthquake-induced failure mechanisms, construction types and materials, intervention and assessment techniques will be cross-correlated with the aim of developing new integrated methodologies with a systemic approach. Traditional materials will be enhanced by innovative industrial processes (e.g., nano-limes or micro-silica for injection), and new high-performance (e.g. dissipative) elements will be developed. Novel collaborative combinations of them will be tested on structural components (walls, pillars, floors, vaults) and on structural connections (wall-, floor- and roof-to-wall), which converge the behaviour of single strengthened elements into the global structural response. The envisaged techniques will be also validated on model buildings and substructures. Advanced numerical studies will allow parameterizing the results and deriving simple and optimized design procedures. Early warning techniques for intelligent interventions and advanced monitoring techniques for knowledge based assessment and progressive implementation of interventions will be also developed. This bottom-up approach will bring to new integrated materials, technologies and tools for systemic improvement of seismic behaviour of CH assets. The new solutions will be condensed into guidelines for end-users. The large participation of research centres, SME, and end-user from various countries, including ICPC and MPC, ensures increased impact of the research.",NEW INTEGRATED KNOWLEDGE BASED APPROACHES TO THE PROTECTION OF CULTURAL HERITAGE FROM EARTHQUAKE-INDUCED RISK,FP7,31 December 2012,01 January 2010,2736114.0 NIM_NIL,Profactor GmbH,manufacturing,"Three-dimensional large area metamaterials, especially Negative Index Materials (NIMs) promise to enable numerous novel and breakthrough applications like perfect lenses and cloaking devices, not only but especially if they exhibit the desired properties in the visible frequency range. For the European Photonics industry it is of paramount importance enabling fabricating such materials as soon as possible, to maintain its important position in the areas of optical components and systems as well as production technologies. Till now such materials have not been produced, yet - neither in 3D nor on large areas, let alone both combined. The aim of NIM_NIL is the development of a production process for 3D NIMs in the visible regime combining UV-based Nanoimprint Lithography (UV-NIL) on wafer scale using the new material graphene and innovative geometrical designs. This project will go beyond state-of-the-art in three important topics regarding NIMs: the design, the fabrication using Nanoimprintlithography (NIL) and the optical characterization by ellipsometry. New designs and the new material Graphene will be investigated to extend the existing frequency limit of 900 nm into the visible regime. The fabrication method of choice is UV-NIL since it allows cost efficient large area nanostructuring, which is indispensible if materials like NIMs should be produced on large scale. The negative refraction will be measured using ellipsometry which is a fast and non-destructive method to control the fabrication process. At the end of the project a micro-optical prism made from NIM will be fabricated to directly verify and demonstrate the negative refractive index. Each aspect of innovation within NIM_NIL -design, fabrication and characterisation of NIMs -is represented by experts in this field resulting in a multidisciplinary highly motivated consortium containing participants from basic research as well as industrial endusers from whole Europe.",Large Area Fabrication of 3D Negative Index Metamaterials by Nanoimprint Lithography,FP7,31 August 2012,01 September 2009,3373100.0 NINA,Linköping University * Linköpings Universitet,energy,"My recent discovery of the anomalously high thermoelectric power factor of ScN thin films demonstrates that unexpected thermoelectric materials can be found among the early transition-metal and rare-earth nitrides. Corroborated by first-principles calculations, we have well-founded hypotheses that these properties stem from nitrogen vacancies, dopants, and alloying, which introduce controllable sharp features with a large slope at the Fermi level, causing a drastically increased Seebeck coefficient. In-depth fundamental studies are needed to enable property tuning and materials design in these systems, to timely exploit my discovery and break new ground. The project concerns fundamental, primarily experimental, studies on scandium nitride-based and related single-phase and nanostructured films. The overall goal is to understand the complex correlations between electronic, thermal and thermoelectric properties and structural features such as layering, orientation, epitaxy, dopants and lattice defects. Ab initio calculations of band structures, mixing thermodynamics, and properties are integrated with the experimental activities. Novel mechanisms are proposed for drastic reduction of the thermal conductivity with retained high power factor. This will be realized by intentionally introduced secondary phases and artificial nanolaminates; the layering causing discontinuities in the phonon distribution and thus reducing thermal conductivity. My expertise in thin-film processing and advanced materials characterization places me in a unique position to pursue this novel high-gain approach to thermoelectrics, and an ERC starting grant will be essential in achieving critical mass and consolidating an internationally leading research platform. The scientific impact and vision is in pioneering an understanding of a novel class of thermoelectric materials with potential for thermoelectric devices for widespread use in environmentally friendly energy applications.",Nitride-based nanostructured novel thermoelectric thin-film materials,FP7,30 September 2018,01 October 2013,1499976.0 NINFA,University of Essex,health,"This proposal is concerned with optically-injected nanostructure lasers, including quantum-dot and quantum-dash semiconductor lasers and the potentials of these devices for Ultra-High Frequency applications, including Terahertz (THz) technologies. In particular, attention will be focused on long-wavelength devices, emitting at the very important telecom wavelengths of 1310 and 1550nm. The aim of this proposal is to analyze experimentally and in theory the effect of optical injection in several nanostructure lasers, including Fabry-Perot, Distributed-Feedback (DFB) and multisection DFB devices with quantum dot and quantum dash active regions. The investigations will include the analysis of the injection locking properties and the mapping of the different regions of nonlinear dynamics when the devices are subject to weak optical injection. In addition, the enhancement of the modulation bandwidth and resonance frequency when these devices are subject to high and ultra-high external optical injection will also be investigated throughout the Fellowship. The limits in the enhanced frequency response will be analyzed for different designed optically-injected nanostructure lasers and the prospects of these devices for use in Ultra-High Frequency applications will be explored. In particular, attention will be focused in pushing up the frequency response of these devices to the THz frequency range which has a wide variety of applications in very disparate fields, including communications, biology, medicine, security, sensing etc. Hence, the vision of this project will be the practical development of a Tuneable THz oscillator built directly from simple and compact photonic components such as nanostructure semiconductor lasers totally compatible with optical communications technologies.",Nanostructure Injected Lasers for Ultra-High Frequency Applications,FP7,30 September 2014,01 October 2011,239221.0 NINIVE,Sant'Anna School of Advanced Studies * Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna,health,"Nanotechnology is expected to have a major impact on biomedical research, leading to new types of diagnostic and therapeutic tools. One focus in nanobiotechnology is the development of nonviral vectors for safe and efficient gene delivery. Progress in the Human Genome Project increases the attractiveness of gene therapy as a therapeutic modality for a host of diseases. Today the methodologies for in vivo gene transfection are still in their infancy. The most promising method is based on the use of viral vectors, but its safety is actually under discussion. This project aims at developing a nonviral vector for gene delivery, able of a) gene transfection in vivo and on a large amount of cells, b) local and non invasive therapy, c) frequent and easy medication. This nano-device will be based on a carbon nanotube (CNT). It will be coated with genes to be transfered, and will be functionalized with a ligand, able to bind a receptor expressed by the target cells to be transfected. A solution containing a myriad of vectors will be dispensed locally in the target tissue, e.g. via injection; each of them will localise a target cell and bind it. Two strategies of cell transfection will be investigated: 1) cells up -take the vectors via endocytosis and 2) genes are transferred in the cell membrane via electroporation (i.e. via permeabilization of cell membrane by application of short-duration electric field pulses). In the second case, current impulses could be generated in CNTs via electromagnetic fields, by exploiting the properties of CNTs like antennas. In order to prove these paradigms, in vivo validation of the nanotransducer vectors will be performed. A specific neurological disorder will be treated to demonstrate their therapeutic potential. The implementation of this proposed solution requires a multidisciplinary approach and the integration of expertise in the fields of nanotechnologies, biotechnologies, communication technologies and neuroscience.",NON INVASIVE NANOTRANSDUCER FOR IN VIVO GENE THERAPHY,FP6,31 January 2010,01 December 2006,1747777.0 NIRNANOBIOSENS,Friedrich Schiller University of Jena * Friedrich-Schiller-Universität Jena,health,"The aim of this project is to develop quantitative biological sensors based on fluorescent spherical silicate nanoparticles (amorphous silica, zeolite beta) in controlled sizes in the range of 50 to 200 nanometers in diameter. The quantification of the analyte is based on a ratiometric detection of fluorescence from two dyes. The dyes are chosen such that the fluorescence of one dye is a function of an analyte (ion, biomolecule) concentration (sensing dye) whereas the fluorescence of the other dye is independent of variations in the medium (reference dye). Both dyes have the near-infrared light absorption property which lead to significant improvements for the detection in biological samples. The first step consists in confining a dye in the inorganic network yielding highly brilliant and photostable objects. Thus this fluorescent hybrid core can be used as the reference dye. Afterwards the ability of such material to undergo further chemical modification through the surface silanol functions and the use of coupling agents allows the immobilization of the sensing dye (commercially available or developed in the host structure). This is considered through various strategies e.g. direct immobilization or embedded polymeric shell.",Developement of robust and quantitative biosensors based on near-infrared two-dyed silicate nanoparticles,FP7,30 April 2010,01 March 2008,158694.0 NIRPLANA,Istituto Italiano di Tecnologia (IIT),energy,"Plasmonics is a hot and rapidly expanding research field. Of particular interest is the localized surface plasmon resonance (LSPR) observed in noble metal nanocrystals (NCs). It leads to strong light scattering and enhanced light-matter interaction. However, the LSPR of metal NCs is restricted to visible wavelengths, unless multipole resonances are enhanced via shape engineering of the NCs. Recently, two papers were published showing that copper-deficient semiconductor Cu2-xS(e) NCs can also exhibit a strong LSPR, in the near-infrared (NIR) spectral region. This exciting result both pushes the LSPR to longer wavelengths and allows plasmonics using semiconductor materials, which are transparent near the LSPR wavelength. The project aims at expanding this new field by focusing on the fabrication of a NIR photovoltaic cell with enhanced performance. This is achieved through incorporation of NIR plasmonics NCs, which allow improved absorption in the active layer via strong light scattering in NC thin film and an enhancement of the electric field near the NC surface. Two crucial steps need to be taken to achieve our goals. First, we need to further develop the synthesis of novel NIR plasmonic NCs. The focus lies here on a tuning of the spectral position and width of the LSPR by varying the Cu2-xS(e) material composition, size and shape, in order to optimize the NC scattering cross section and field enhancement at the desired NIR wavelength. Second, strategies will be developed to incorporate the plasmonic NCs into novel NC-based thin film photovoltaic cells. The device performance will be evaluated with and without plasmonic NCs, for different thin film configurations, in order to quantify the efficiency enhancement. Considering that our devices combine an improved absorption with an expansion of the photovoltaic response into the NIR, we expect that NC-based photovoltaics can offer a viable low-cost alternative to current solar cell technologies.",Near-Infrared Semiconductor Plasmonic Nanocrystals for Enhanced Photovoltaics,FP7,15 May 2014,16 May 2012,193726.0 NIRVANA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"With the recent introduction of MEMS in consumer applications (mobile phone, gaming…) the market for low cost and low power consumption multi-axis inertial sensors has boomed over the last five years. These sensors have generated huge business opportunities, with $M.1900 revenues in 2009 at the MEMS level. Beyond consumer applications, there are many other growing mass market applications like IPTV remote control, sport or eHealth. For these domains, lower consumption, miniaturization, integration and ultimately lower cost of production are essential to address and dominate this market. The same applies for high end niche markets such as implantable sensors in medical field. To address these needs, NIRVANA project aims to develop a very low cost and very low power consumption 9-axis inertial sensor based on a new concept and technology using nano-scale detection means. The idea is to take advantage of the very high sensitivity and low impedance of silicon nano-wire gauge to optimize the dimensions and the integration of the sensor and to reduce the overall power consumption. At this end, innovative sensor designs, disruptive technology (mixing MEMS and NEMS technologies, and including packaging with TSV), and new electronics architectures will be developed in this project. The targeted goal is to validate the integration of 9-axis sensor based on nano-wire gauge detection, having a surface and cost 2 to 4 times less than the current commercial components and with power consumption 3 to 5 times lower. Special emphasis will also be put on the characterization and reliability of these sensors. To ensure the success of this ambitious project, a consortium has been established, with leading research groups (LETI, POLIMI, FhF-IIS) and key industrials partners: Two end-users (MEDEL and MOVEA), and the inertial MEMS manufacturer world leader in the consumer segment (STM), will guarantee the real and prompt exploitation of the developments and results of the NIRVANA project",NINE-AXIS INERTIAL SENSOR BASED ON PIEZORESISTIVE NANO-GAUGE DETECTION,FP7,31 August 2014,01 September 2011,2607000.0 NISIS,ELITE European Laboratory for Intelligent Techniques Engineering,information and communications technology,"NiSIS overall mission aims: - to co-ordinate multi-disciplinary studies and research endeavours into the development and utilisation of intelligent paradigms in advanced information systems design. - to extend investigations into emerging new areas inspired by nature, both at biological (ie.micro) and behavioural (ie. macro) levels for visionary concepts of information processing and architectures. The project will comprise four parts aiming to interconnect different disciplines and activities in an effective scheme: A) The core of the project is a set of three Focus Groups which are to deliver the scientific and technological contributions of the programme. There are Focus Groups on: Nature-inspired Data Technology, Nature-inspired Networks, and Nature-inspired Systems Modelling, Optimisation and Control. B) Technology Transfer will take results from the 3 Focus Groups in terms of technological concepts and algorithms, but also contribute challenges via Competitive Workshops concentrating on benchmarking situations taken from real-life relating to IST situations. Training and Education will give added-value in terms of cross-disciplinary instruction and motivation etc. for an upcoming generation of young researchers. C) The overall integration of the Project will be overseen by an ITB (Integrated Technology Board), with participants from all of the above groups and committees, thus providing both �pulling� technology from the life sciences and �driving� the technology into IST via technical co-ordination of the project and a comprehensively designed Roadmap. D) The co-ordination of NiSIS will be achieved via the management component provided by the ELITE Foundation. Apart from the overall co-ordination, assessment of the Project and project activities supervision, the Co-ordinator will seek collaboration between the participating multidisciplinary Partners as well as new potential partners enhancing the research opportunities of NiSIS.",Nature-inspired Smart Information Systems,FP6,31 January 2008,31 January 2005,1000000.0 NITLAB,University of Milan * Università degli Studi di Milano,health,"The main aim of the present proposal is to bring researchers involved in biomedical research closer to the large public, without any distinction of age, gender, level of scientific training or social category. The proposed action intends to oppose the stereotypes about researchers and their profession, giving the opportunity to perceive them as 'ordinary people'. On the other hand, in the last years, people have asked to biomedical researchers for more information about their work and the effect on public health. Therefore, showing a researcher 'from inside', stressing his/her 'ordinary' features could help in attracting people to scientific careers and rise the perception of the role of researchers in our society . The proposal foresees the organization of a high impact event in the beautiful and ancient cloister of the University of Milan, giving an opportunity to young and adult people to meet researchers involved in biomedicine and nano-medicine, to see them at work and to work with them, taking part in real laboratory activities. Buffet, music and a drama show entitled 'The day of a researcher' will create an informal and pleasant atmosphere. Local institution such as 'Comune di Milano, Assessorato alla Salute' will support the event. Sophisticated instruments will also be shown and used during the laboratory activities. An 'official' award ceremony will take place, during which the winners of the photo competition will receive a prize at 'Aula Magna' of the University of Milan. A representative of the Municipality of Milan together with a representative of the University of Milan will announce the winners and will describe the award foreseen by the Commission for the winner. The Commission is composed by photographic reviewers known at national and international level. The target audience of the event is very wide: from children up to aged people, e.g. all the ordinary people being part of the society.",A night in the lab,FP7,30 November 2008,01 June 2008,28600.0 NITRICARE,University of Vienna * Universität Wien,health,"Nitrification is a central component of the Earth's biogeochemical nitrogen cycle. This process is driven by two groups of microorganisms, which oxidize ammonia via nitrite to nitrate. Their activities are of major ecological and economic importance and affect global warming, agriculture, wastewater treatment, and eutrophication. Despite the importance of nitrification for the health of our planet, there are surprisingly large gaps in our fundamental understanding of the microbiology of this process. Nitrifiers are difficult to isolate and thus most of our current knowledge stems from a few cultured model organisms that are hardly representative of the microbes driving nitrification in the environment. The overarching objective of NITRICARE is to close some of these knowledge gaps and obtain a comprehensive basic understanding of the identity, evolution, metabolism and ecological importance of those bacteria and archaea that actually catalyze nitrification in nature. For this purpose innovative single cell technologies like Raman-microspectroscopy, NanoSIMS and single cell genomics will be combined in novel ways and a Raman microfluidic device for high-throughput cell sorting will be developed. Application of these approaches will reveal the evolutionary history and metabolic versatility of uncultured ammonia oxidizing archaea and will provide important insights into their population structure. Furthermore, the proposed experiments will allow us to efficiently search for unknown nitrifiers, evaluate their ecological importance and test the hypothesis that organisms catalyzing both steps of nitrification may exist. For non-model nitrifiers we will develop a unique genetic approach to reveal the genetic basis of key metabolic features. Together, the genomic, metabolic, ecophysiological and genetic data will provide unprecedented insights into the biology of nitrifying microbes and open new conceptual horizons for the study of microbes in their natural environments.",Nitrification Reloaded - a Single Cell Approach,FP7,30 April 2017,01 May 2012,2499107.0 NITWAVE,University of South Paris * Université Paris-Sud,photonics,"This project aims at investigating the building blocks of an emerging semiconductor technology for ultra-high bit�rate optoelectronic devices operating at fibre-optics telecommunication wavelengths. The advanced materials that we will investigate are nitride-based heterostructures (GaN/Al(Ga)N, GaN/AlInN). We will engineer the electronic quantum confinement at a nanometre scale to realize active devices relying on intersubband absorption/emission at 1.3-1.55 um. The ultimate deliverables are high-speed photodetectors, optical switches and modulator devices. We will also investigate optically and electrically pumped emitting devices as stepping stones towards advanced unipolar sources (Quantum Fountain and Quantum Cascade lasers/amplifiers). While existing semiconductor technology is dominated by InP-based interband devices, nitride intersubband devices will provide novel functionalities and superior performances like wavelength tunability, speed, high power handling capabilities, and material hardness. The potential of intersubband devices has already been demonstrated at mid- and far-IR wavelengths using GaAs- or InP-based materials. Our project doesn�t target the operating principles but will exploit the know-how acquired at longer wavelengths to push this family of devices to unprecedented short wavelengths, thanks to the large conduction band offset offered by nitride heterostructures. Establishing a new state-of-the-art for growth and processing of nitride semiconductors, and developing an advanced know-how on nitride devices are major challenges of the project. The consortium regroups world�class experts on nitride technologies and intersubband devices, and the chosen strategies have been chosen to minimize the risks. This high-risk, but achievable project will enable Europe to capitalize on SandT advances, developing a lead with respect to USA and Japan competitors and preparing the future transfer of this emerging technology to the optoelectronic industry.",Nitride Intersubband Devices at Telecommunication Wavelengths,FP6,31 July 2007,31 May 2004,1932000.0 NLL,Bilkent University * Bilkent Üniversitesi,manufacturing,"Control of matter via light has always fascinated humankind; not surprisingly, laser patterning of materials is as old as the history of the laser. However, this approach has suffered to date from a stubborn lack of long-range order. We have recently discovered a method for regulating self-organised formation of metal-oxide nanostructures at high speed via non-local feedback, thereby achieving unprecedented levels of uniformity over indefinitely large areas by simply scanning the laser beam over the surface.",Nonlinear Laser Lithography,FP7,05 July 2021,06 January 2014,0.0 NMNP,Technion Israel Institute of Technology,photonics,"We will investigate, experimentally and theoretically, the dynamics of nonlinear optical waves at mesoscopic scales, ranging from several wavelengths (~10 microns) down to the sub-wavelength regime (~0.2 microns). Our studies will cover a variety of optical settings: from various kinds of periodic systems (photonic lattices) with and without disorder, to bulk materials and nano-suspensions. Under proper conditions, light propagating nonlinearly in these systems can display complex nonlinear dynamics, giving rise to a variety of fascinating phenomena. Perhaps the most intriguing are associated with the suspensions containing dielectric nano-spheres, upon which light acts, by virtue of the gradient force, to modify the local density of spheres, thereby varying the effective refractive index. We will use light to alter the properties of the fluid (e.g., surface-tension, viscosity), which, in turn, will affect the pattern of optical wave in space and time. We will study nonlinear optics coupled directly to nonlinear fluid dynamics. Our preliminary results demonstrate optically-induced convection and optically-driven waves in the fluid. In the same system, we will explore sub-wavelength optical spatial solitons. Our preliminary experimental results clearly show very narrow solitons, narrower than imaging optics can resolve. In another effort, we will explore arrays of sub-wavelength waveguides with a sharp index contrast, and will study a variety of nonlinear phenomena unique to such structures. Other efforts include linear and nonlinear wave phenomena in photonic lattices, such as Anderson localization of lightt, the optical realization of the famous Hofstadter butterfly, waves in honeycomb lattices exhibiting unique features arising from symmetry (diabolic points, Berry phase effects, backscattering, etc.), Anderson localization in quasi-crystals and in honeycomb structures, transport of solitons in random potentials, and more.",Nonlinear Micro- and Nano-Photonics: nonlinear optics at the micrometer scale and below,FP7,30 September 2014,01 October 2008,2100000.0 NMS-CNT,University of Brighton,health,"The partners wish to build a long-term European, industry-academia consortium, to work on the problem of repairing tissue damage in the neuromuscular system (NS). We initially seek to determine the biocompatibility of carbon nanoparticles with tissues of the NS as an essential prelude to our medium to long-term goal of developing marketable novel carbon nanotube-based implants for tissue repair of the NS. Presently, there is no satisfactory method for repairing extensive damage of the different tissues of the NS namely, nerves, muscles, ligaments and tendons. In the case of nerve lesions, the major problem associated with most of the recently developed implants is their limited capacity for organising regenerating axons appropriately for functional tissue re-innervation. We believe that CNTs due to their unique combination of physico-chemical properties could play a major role in overcoming these problems and therefore enhance tissue integration and nerve repair. In the case of damaged skeletal muscles and tendons, we envisage that CNTs could play a key role in strengthening and repair of these types of NS tissues.",Biocompatability of carbon nanoparticles with tissues of the neuromuscular system,FP7,30 April 2013,01 May 2009,633648.0 NOBLEMED,Universiteit Utrecht * Utrecht University,health,"The aim of the proposed research is to develop a new (Au-NP) gold nanoparticle-based drug delivery systems. For this new synthetic approach, three different components are designed; namely, new tailored gold nanoparticle, cleavable linkers, and new platinum-based drugs. The first component is a new tailored Au-NP, which will be synthesized using a multidentate thioether 'coating ligand'. Unlike the gold nanoparticle-based nanocarriers used till date, this novel nanomaterial enables accurate functionalization of the particle surface using a multidentate ligand, allowing also controlled particle size and shape. Moreover, tuning of the gold-surface properties is easily performed by functionalization of the coating ligand, leading to a well defined drug load per particle. The functionalization also enables the attachment of linkers (second component of the system) of a programmable variety on the outer-shell of the Au-NP, which will serve as bridges between the nanocarrier and the drug. The proposed approach is the use of cleavable linkers to reach a new level of drug-controlled release. Inspired by cancer biology, peptide linkers will be attached to the coating ligand of the gold nanoparticle. These peptides will be cleaved by overexpressed proteases in cancer tissue, achieving tumor-specific drug (endogenous) release. In addition, exogenous activation of drug release using photolabile linkers will be explored, leading to new class of external controlled platinum drug release. To test this approach, platinum-based drugs (third component), which display high cure rates against several cancers (ovarian, head neck, testicular and lung cancer), will be attached to the nanocarriers using different cleavable linkers. In addition to the synthesis and characterization of these systems, in vitro studies in cancer cells will be performed to investigate their cellular processing, and establish their mechanisms of action.",Regulated release of Pt-based drugs from multi-component Au-nanocarriers,FP7,30 June 2014,01 July 2011,228529.0 NOBLESSE,PAN - Institute of Physical Chemistry * Instytut Chemii Fizycznej,health,"The overarching goal of the NOBLESSE project is to establish the Institute of Physical Chemistry, Polish Academy of Sciences (IPC-PAS) as an integrated partner and respected participant in the European nanoscience community. The IPC-PAS has a strong research record in both fundamental studies of physiochemical processes as well as application oriented research. The use and control of nanostructured materials is of great importance for the development of new environmentally friendly materials, more efficient energy-sources and biosensors for medical analysis. The NOBLESSE project will bring essential equipment to the institute, but also help create a Polish nanoscience network to survey the major equipment at Polish research centres and make sure that necessary equipment is available to the researchers. This will be an important development not only for IPC-PAS but for Polish nanoscience as a whole. A major part of the NOBLESSE project is reinforcing the research potential of the Institute by bringing in new experienced researchers and strengthening the staff through a number of supporting activities such as training programs, networking, improvements in dissemination and collaboration with industry. The most important part of fully integrating the IPC-PAS into the ERA community is the establishment of strong partnerships with mutual staff secondments with a network of leading EU research centres sharing scientific interests. This will lead to a large contact area, promoting the Institute and further integrating its staff into EU projects and international collaboration. The planned activities within NOBLESSE will firmly position IPC-PAS as a leading research centre on a national level, contribute to preventing brain drain by offering young devoted researchers competitive resources and facilitate the exchange of know-how with the wider scientific community but equally important with the public and potential business partners. The creation of stronger bonds between academia and industry is of vital importance for IPC-PAS and for society as a whole.","NanOtechnology, Biomaterials and aLternative Energy Source for ERA integration",FP7,30 September 2014,01 October 2011,3321290.0 NODE,Lund University * Lunds Universitet,health,"NODE focuses on an innovative bottom-up approach to fabrication and integration of nanoelectronic devices, based on self-assembling semiconductor nanowires. The primary target is to deliver replacement and add-on technologies to silicon CMOS, such as FET devices for logics and III-V bipolar transistors for RF applications. NODE will study key device families based on semiconductor nanowires, assess their compatibility with conventional semiconductor processing, and evaluate novel architectural concepts and their implementation scenarios. It is the overall objective of the NODE Integrated Project to demonstrate that nanowire-based device technology is the disruptive technology needed for long-term innovation and growth in the electronics industry. NODE hereby takes on the challenge as formulated in the IST Work 'programme' breaking new barriers with current CMOS technology below 10 nanometers as well as the exploration of alternative materials'. The partners are leading academic groups in nanowire research and semiconductor nanofabrication, research laboratories from major European electronics industries (Philips, IBM and Infineon), an SME-company specialized in nanowire device technology (QuMat), as well as a major European Si-technology research centre (IMEC). This coverage of the entire science-technology-application chain among the partners ensures early access for the European electronics industry to the knowledge generated within NODE, and maximizes the likelihood of effective exploitation of its results. At the end of the project, a selection of the most promising nanowire technologies will have been made and the incorporation of nanowire devices into Si-technology demonstrated. It is further expected that the knowledge gained will support other European science and technology efforts, e.g. in quantum information technology, in opto-electronics, photo-voltaics, and general lighting, as well as in nanomechanics (NEMS), sensors and bio-medical application.",Nanowire-based One-Dimensional Electronics,FP6,31 August 2009,31 August 2005,9496000.0 NOESIS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),transport,"The increased use of high performance composites as structural materials in aerospace components is continuously raising the demands in terms of dynamic performance, structural integrity, reliable life monitoring systems and adaptive actuating abilities. This project will exploit the unique properties of Carbon Nanotubes (CNTs) as a matrix dopant in Fibre Reinforced Plastics (FRP), with the aim of producing structural composites with improved mechanical performance as well as sensing / actuating capabilities.The development of new generation composites using CNTs as filler material within the matrix is expected to result in the enhancement of the damping properties of the material, the increased fracture toughness and the improvement of its fatigue life. This is expected to occur due to the multiplicity of energy dispersive mechanisms within the material. At the same time, the percolated CNT network within the composite is expected (i) to be strain sensitive and (ii) closely related to internal damage mechanisms within the material, providing thus the sensing and life-assessment tool throughout the service life of the material. At the same time, the electromechanical response of CNTs provides the field for the design of actuating systems comprised of CNT structures of varying degree of anisotropy that will be incorporated in the composite. Additionally, the dependence of the Raman shift on the local stress of CNTs can provide unique insight on the stress field at nanoscale level.The challenge that this project is facing is to successfully combine the CNT properties and existing sensing actuating technologies realising a multi-functional FRP structure; this will be achieved through a detailed property assessment with concurrent modelling from nano- to macro- to multi scale level and validation. The expected outcome is the successful integration of emerging nanotechnologies in structural aerospace components with enhanced mechanical properties.",AEROSPACE NANOTUBE HYBRID COMPOSITE STRUCTURES WITH SENSING AND ACTUATING CAPABILITIES,FP6,30 June 2009,01 April 2005,3080818.0 NOLACOME,Vienna University of Technology * Technische Universität Wien,photonics,"The past decade has witnessed a stupendous growth in research activity on the way we control the flow and storage of photons. This activity has been, to a large extent, driven by the enormous progress in micro- and nano-fabrication capabilities of photonic media. The presented proposal aims at a theoretical and computational study of Non-linear optics and Lasing in Complex Photonic Media, enabled by this capability. The complexity of these media stems from their non-trivial spatial structure which is required for the control of electromagnetic radiation in various applications like novel micro- and nano-lasers. The proposed research will focus on four main topics: the role of a spatially non-uniform pump/gain medium in laser characteristics and its interplay with the resonator geometry for the design of compact and power-efficient lasers; lasing in Parity-Time (PT) symmetric cavities and its relation to unidirectional invisibility and the anti-laser; existence of a statistical signature of Anderson Localization in Random Lasers; theoretical techniques to study collective effects in Non-linear Optics that derive from the complexity in the photonic structure used to confine light. Results from these research activities are expected to have impact both on basic research and on applied technology for the design of novel and improved photonic devices.",Nonlinear Optics and Lasing in Complex Media,FP7,31 May 2015,01 June 2012,261853.0 NOLIMIT,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Focusing light to the (sub)micron scale is the enabling element in many important biomedical and industrial applications, such as optical microscopy and laser nano-surgery. However, the inherent inhomogeneity of biological tissues induces light scattering which limits effective focusing to shallow depths of a few hundred microns. As a result, optical microscopy, perhaps the most important tool in biological discovery and medical investigation, is currently restricted to superficial investigation. Nevertheless, recent results have shown that the effects of such 'random' scattering can be undone, controlled, and even exploited by high-resolution wavefront shaping. The goal of this project is to use these novel insights to break the resolution limit of deep-tissue optical techniques, and enable controlled sub-micron focusing and microscopic imaging deep in scattering media. This ambitious goal will be achieved by combining the powerful techniques of the emerging field of 'wavefront shaping' where leading contributions have been made by the applicant and the host, with the penetration depth allowed by photoacoustics, field in which the host has a world-leading expertise. We will be able to go beyond the acoustic wavelength resolution limit of photoacoustics by exploiting nonlinear photoacoustic effects as the control signal for adaptive light focusing, an original insight discovered by the joint work of the applicant and the host in the last few months. Achieving the project's goal would be both a scientific and technological breakthrough as well as a having a huge potential impact on societal issues, with the hope of substituting invasive biopsy procedures and allowing imaging through complex samples in industry.",Nonlinearity-assisted Optical Focusing and Imaging Deep Inside Scattering Media,FP7,31 May 2015,01 June 2013,269743.0 NOMGCNP,Cardiff University,manufacturing,The present synthetic methodologies in chemical industry must be significantly improved to enable producing many chemicals by employing environmental-friendly and sustainable procedures. One of the main challenges for establishing a sustainable society is to mimic natural photosynthesis and develop stable and efficient photocatalysts for various chemical transformations under visible light irradiation that is almost never depleted out.,Mesoporous Graphitic Carbon Nitrides Supported Noble Metal Nanoparticles for Green Catalysis under Visible Light,FP7,08 July 2016,09 January 2012,0.0 NOMS,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"Nano-optical mechanical actuation based on nanotube-enriched polymeric materials is a much sought-after technology. In this scheme, light sources promote mechanical actuation of the polymeric materials producing a variety of nano–optical mechanical systems such as tactile displays, artificial muscles, and nano-grippers among others. The purpose of the NOMS project is to fabricate microsystems capable of light-induced mechanical actuation. In particular, the team proposes to build a visual-aid tablet for the blind or partially-sighted. Accomplishing this ambitious project requires knowledge of basic and integrating research within the field. It also requires the contribution of expert neuropsychologists to study, in cooperation with end-users, the effectiveness of the tablet both as an assistive tool for the visually impaired and as a research tool in the field of neuropsychology. The consortium is formed by experts in the areas of materials, optics, microsystems, neuropsychology, as well as end users, who will fabricate the first visual aid tablet. This well-balanced team possesses a unique combination of talent to guarantee achievement of the project objectives. The NOMS approach ensures that a solution (photo-actuated nanomaterials) will be provided to a particular problem (fast-refreshed portable visual-aid devices). NOMS will provide tactile screens for the visually impaired to read complex visual representations such as mathematical equations and graphical images. Everyday activities of such individuals will be greatly improved by including these devices in ATMs, personal computers, mobile telephones etc. This project is visionary with respect to some of the mainstream R&D directions, offering European industry a competitive advantage in the assistive technology marketplace worldwide. Appropriate industrial partnerships with adequate technology transfer experience have been included in the consortium with the purpose of thorough exploitation of the technology.",NANO-OPTICAL MECHANICAL SYSTEMS,FP7,08 July 2014,09 January 2009,2549965.0 NONLINSUPFOC,Ben-Gurion University of the Negev,photonics,"I propose a theoretical study of the effects of a self-focusing nonlinearity in plasmonic nano-structures. First, I will exploit the field enhancements in tapered plasmonic waveguides in order to implement strong nonlinear modifications of the plasmon wavelength and group velocity. I would like to achieve slow light, and if possible, even stopped and reversed light. Second, I will study nonlinear focusing in plasmonic waveguides, an effect which unlike soliton formation, was not studied in the context of plasmonics before. Nonlinear focusing, also known as beam collapse, corresponds to focusing of macroscopic beams down to the diffraction limit, but not beyond it. Thus, it is of fundamental interest to study this effect in plasmonic systems that do allow beams of subwavelength sizes in order to unveil the maximal focusing level achievable. Furthermore, I will study the analogy between the geometrical focusing imposed by the tapering and the nonlinear focusing imposed by the self-focusing nonlinearity. Third, I will exploit the link between plasmonic waveguides and metal nano-particle pairs, as established by transformation optics techniques, to study the effect of a self-focusing nonlinearity on the super-focusing effect in the nano-particle pair geometry. This will be done by extending the linear theory of transformation methods to nonlinear media. The proposed research aims at the realization of novel and stronger than ever nonlinear effects in the tapered waveguides, at the realization of diffraction-unlimited nonlinear focusing, and the realization of nonlinear effects at ultimately small volumes in the nano-particle geometries. As such, the research aims at bridging the gap between the plasmonics and nonlinear optics communities, thus stimulating further studies of nonlinear plasmonic systems. In addition, the research may lead to the development of techniques such as nonlinear transformation-optics whose relevance extends to many other wave systems.",Nonlinear super focusing in plasmonic systems,FP7,28 February 2017,01 March 2013,100000.0 NONPLASMETA,Imperial College London,photonics,"The main goal of the proposed research project is the modelling and theoretical analysis of a new class of artificial metamaterials exhibiting a strong nonlinear optical response at visible and near-infrared frequencies.The promising properties of these new photonic materials are assisted by surface plasmon polaritons supported by the metallic subunits forming the metamaterial. The nonlinear response can be due not only to the metallic nanostructures, but also to the presence of nonlinearities in the substrate or embedding layer. The investigation on nonlinear plasmonic metamaterials combines three of the most active and fruitful research areas in photonics during the last decade: plasmonics, metamaterials science and nonlinear optics. Despite of the crucial importance of nonlinear effects in current photonic applications (such as laser and imaging technologies), nonlinear processes have not been yet incorporated into the metamaterial approach. In my research, I will take advantage of nonlinear effects to develop metamaterials at visible and near-infrared frequencies by overcoming the high absorption that electromagnetic fields suffer when propagating within metallic structures. The study of nonlinear plasmonic metamaterials may lead to the discovery of novel optical properties not found in nature. The profound comprehension of the fundamental physics behind these new photonic materials lies at the core of this proposal. However, the technological implications of this research project are clear. Nonlinear plasmonic metamaterials will open the way to the design of actively controlled and multi-functional optical materials which are the first step towards a new generation of highly effective optical devices such as switchers, routers, intelligent surfaces and subwavelength imaging devices.",Nonlinear Plasmonic Metamaterials,FP7,31 May 2012,01 June 2010,180603.0 NORDIA,Technion Israel Institute of Technology,health,"Deformable and non-rigid objects, both natural and artificial, surround us at all scales from nano to macro, and play an important role in many applications ranging from medical image analysis to robotics and gaming. Such applications require the ability to acquire, reconstruct, analyze, and synthesize non-rigid three-dimensional shapes. These procedures pose challenging problems both theoretically and practically due to the vast number of degrees of freedom involved in non-rigid deformations. While modelling and analysis of non-rigid shapes has greatly advanced in the past decade, existing solutions are largely based on parametric models restricting the objects of interest to a narrow class of similar shapes. Broadly speaking, reconstruction, analysis, and synthesis of arbitrary deformable shapes remain unsolved problems, a practical solution of which would be a major milestone in computer vision and related fields. This proposal aims at answering these fundamental questions by adopting tools from modern metric geometry, a field of theoretical mathematics which in the past few decades has undergone a series of revolutions that remained largely unnoticed and unused in applied sciences. We believe that metric geometry tools could systematically answer these questions, and, coupled with modern numerical optimization techniques and novel hardware architectures, pave the computational way to the next generation in deformable shape analysis. We plan to develop such numerical tools while demonstrating their efficiency on several challenging real-life applications such as surgery prediction and planning, biometry, and computer-aided diagnosis.",Non-Rigid Shape Reconstruction and Deformation Analysis,FP7,31 December 2016,01 January 2011,2121295.0 NOROSENSOR,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"Gastroenteritis, caused by the airborne Norovirus, is the third most deadly infectious disease worldwide, infecting ~4% of the population annually, worldwide, and has related costs measured in billions € annually in the EU alone. Today, detection of airborne viruses can only be done in retrospect in the laboratory, which severely limits the ability to rapidly react and limit the spread of an outbreak. The NOROSENSOR consortium will address this problem by developing the first of its kind, real-time sensor for airborne viruses, with particular focus on the NoV. Because the virus concentration in air can be very low, and because rapid and efficient virus trapping and concentration methods have been missing, no solution exists today. The NOROSENSOR project will fill this important need by integrating a number of recently developed, highly powerful technologies: • Novel nanobiotechnology: nanobead enhanced rolling circle amplification (nano-RCA), engineered synthetic DNA aptamers, and proximity ligation assays (PLA) • First ever airborne nanoparticle manipulation: capturing, filtering and up-concentration of viruses using acoustophoresis and electrostatic precipitation. with beyond state-of-the-art: • Ultra-sensitive QCM mass-sensitive transducers and electronics. • Novel Off-stoichiometry Thiol-Ene-Epoxies (OSTE) polymers for cartridge and reagent storage on-chip. The consortium consist of six of the highest ranked European Universities, each experts in their research area, two SMEs providing a unique expertise in their core business areas, and a large multinational industry in infection control technology.",NOROSENSOR - A real-time monitoring system for airborne norovirus,FP7,30 November 2016,01 December 2013,3400000.0 NOSCE MEMORIAS,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"With the scaling of successive generations of CMOS technologies, further scaling of the different memory types(DRAM, Flash, FeRAM, MRAM) is no longer feasible due to physical and/or cost limitations. Furthermore, theprocesses for various types of memories on CMOS are increasing in complexity and as a result becomingmutually exclusive. This threatens the further scaling of systems-on-chip, on which several memory types(SRAM, DRAM, Flash, ...) often must be integrated simultaneously.As a result, there is a very strong driving force to develop novel memory concepts world-wide. The purpose is tofind materials and concepts that re-unite the following 5 major characteristics : (1 ) scalable for at least severalgenerations from the 45 nm CMOS node on; (2) non-volatile; (3) fast (ns and less) intrinsic switchingmechanism; (4) the technology and materials must be compatible with present-day and future generations ofCMOS; (5) a single and simple technological platform to produce a single unified memory cell should allow togenerate memories with various characteristics by variation of the memory architecture in which such cell isembedded.The present consortium groups two European semiconductor manufacturers, who have, for differentapplications, performed several years of research to screen and preselect candidate memory cells and materials.This strong background allows the consortium to focus on a limited number of two most promising options: oneorganic charge transfer material cell, and one ferro-electric Schottky barrier memory cell.The purpose of the research is to assess the performance and validate the possibility to implement cross-pointmemory cells based on these two options in standard backend-of-line CMOS processes and to demonstrate a reliable and scalable new memory cell concept with cell size down to 4 F�, where F is half the minimum metal pitch.",Novel Scalable Memory Concepts and Technologies,FP6,31 March 2007,31 December 2003,2661795.0 NOTEDEV,Durham University,health,"The realization of efficient, cheap, reliable, scalable and portable terahertz (THz) radiation sources and detectors is one of the important objectives in modern applied physics. THz emitters and detectors have potential applications in biology, medicine, security and nondestructive in-depth imaging. However none of the existing THz devices satisfy the application requirements. The project consortium, which includes teams from the leading European universities: Durham, Vilnius, Paris-7, Exeter, St. Petersburg, Prague, Amiens, University of Iceland, Swiss Company 'Alpes laser' and several industrial associated partners, proposes a broad range of new approaches aiming to bridge the 'terahertz gap': (i) Polariton-based THz emission using microcavities in the strong coupling regime, (ii) New types and concepts of semiconducting materials for short pulsed THz emission, (iii) Carbon nanotubes and graphene as THz emitters and detectors, (iv) Application of Ferroelectric and Multiferroic materials for THz devices. To achieve this objective, we are planning to educate and train a team of collaborating young physicists and device engineers able to conduct research and exploit its application in this new area.",Novel Type of Terahertz Devices,FP7,30 September 2017,01 October 2013,3880542.0 NOVA-CI(G)S,Union Minière SA (UMICORE),energy,"Current production methods for thin film photovoltaics typically rely on costly, difficult to control (over large surfaces) vacuum-based deposition processes that are known for low material utilisation of 30-50%. NOVA-CI(G)S proposes alternative, non-vacuum ink-based simple and safe deposition processes for thin film CI(G)S photovoltaic cells. The low capital intensive, high throughput, high material yield processes will deliver large area uniformity and optimum composition of cells. The project objectives are to achieve competitive about 14% small area cell efficiency and to demonstrate the processes at high speed on rigid and flexible substrates while maintaining acceptably high efficiencies. The processes reduce cost of the CI(G)S layer by 75-80% in comparison to the evaporated CI(G)S, which translates into a 20-25% reduction of total module cost. Major scientific breakthroughs of the project include improved materials control in novel precursor materials by using nano-sized particles of specific chemical and structural characteristics and innovative ink formulation, to enable coating by simple processes while avoiding the use of toxic gases in subsequent process steps. This industry-led project constitutes the first essential step for a fully non-vacuum, roll-to-roll process aimed to achieve the solar module production cost below 0,8 €/Wp that will make photovoltaic directly competitive to traditional energy generation.",Non-vacuum processes for deposition of CI(G)S active layer in PV cells,FP7,30 June 2013,01 January 2010,3474727.0 NOVACOAT,Ceramic Research Ltd.,construction,The aim of this project is to replace conventional glazes on tiles and other high temperature processed materials with an innovative coating. The NovaCOAT consortium aims to develop a nanocomposite coating that is matured at much lower temperatures than the current conventional inorganic glaze coating and has the technical specifications acceptable for ceramic tile applications.The low temperature coating technology is environmentally very sound because it decreases the use of heavy metals and allows use of new decoration technologies and pigments that can not be combined with current high temperature glazed decoration. New decoration techniques and the resulting products will give manufacturers tools to produce truly unique products and thus increase the competitiveness of all participating SMEs.,Replacement of CONVENTIONAL GLAZE on tiles and other high temperature processed materials with with novel hybrid coating,FP6,31 March 2007,01 April 2005,469880.0 NOVEL_MYOKINE,Karolinska Institute * Karolinska Institutet,health,"Cardiovascular disease and diabetes constitute the major disease burden in the western world with growing morbidity. Exercise is known to ameliorate many of the key processes in the pathogenesis of these diseases, but the underlying mechanism is not clear. Especially little is known about how exercise affects non-muscle tissues such as the heart, fat and liver. Knowledge of such pathways could lead to new therapeutic possibilities for diabetes and cardiovascular diseases. I have recently discovered a new hormone, named Irisin. Irisin is regulated by PGC1α, secreted from muscle to plasma after exercise and promotes the formation of brown fat via an unknown receptor. Furthermore, irisin is 100% conserved between mice and humans at the amino acid level (89% identity between zebfrafish and human). Nanomolar levels of this protein increase uncoupling protein 1 (UCP1) in cultures of primary white fat cells by 50 fold or more, resulting in very large increases in uncoupled respiration. Perhaps more remarkable, in vivo delivery of irisin stimulates a robust increase in UCP1, increased energy expenditure and reversal of type II diabetes in high fat fed mice. It is thus likely that irisin is responsible for at least some of the beneficial effects of exercise on the browning of adipose tissues and increases in energy expenditure. The therapeutic potential of irisin is obvious; it is a conserved endogenous polypeptide, induced with exercise and with powerful anti-diabetic properties. Irisin could, for example, be administered exogenously, or the secretion of irisin could be enhanced. These approaches, however, require additional studies, and my aim in this project is to advance the knowledge around irisin for future therapeutic testing. Given success of the ERC grant application, I will move from Harvard/Boston 2012 and start my lab at the department of Cell- and Molecular Biology, Karolinska Institute, Sweden. As seen in my list of publication, Im well prepared for this task",Irisin - a novel myokine protective against metabolic disease,FP7,31 December 2017,01 January 2013,1999433.0 NOVO,"University of Natural Resources and Life Sciences, Vienna * Universität für Bodenkultur Wien",health,"Biofilms are bacterial communities encased in a self-produced hydrated polymeric matrix. An important characteristic of microbial biofilms is their innate resistance to the immune system and susceptibility to antibiotics. This resistance has made microbial biofilms a common cause of medical infections, and difficult-to-treat infections caused by colonized foreign bodies. The NOVO project aims at developing novel approaches to prevent and/or degrade biofilms on catheters elongating their usage in humans up to 10 days. Two complementary approaches for biofilm prophylaxis will be developed: A. Ultrasonic coating of Inorganic antibiofouling agents (process developed by partner BIU) based on a single step sonochemical process to: a) Produce metal fluorides or metal oxides (e.g. MgF2, ZnO) nanoparticles (NPs) and simultaneously b) Impregnate them as antibacterial factors on the catheters. c) Co-coating with bio-inert polymer layers (containing highly hydrophilic antifouling polyethylene glycol, zwitterionic moieties or sugar-groups) grafted onto NPs of adjusted size to the size of MgF2/ZnO NPs or directly onto MgF2/ZnO NPs; to form a hydrogel layer for the protection of the MgF2/ZnO antibiofouling activity. B. Bio/organic antibiofouling activation: 1) Novel coating for catheters based on radical catalyzed polymers to yield anti-bacterial activity. An enzymatic reaction will be applied on the phenolic compounds to generate phenolic radicals to be further polymerized on the catheter surface as an antibiofilm agent. 2) Develop and engineer Cellobiose Dehydrogenases (CDH) that actively oxidizes and degrades biofilms polysaccharides concomitantly producing stoichiometrically H2O2 as antibacterial agent. The enzymes will be coated on the catheters via a lubricant or by the Ultrasonic (US) process after their immobilization. Some novel CDH representatives already show very low activity on glucose which should be removed by further genetic engineering.",Novel approaches for prevention and degeneration of pathogenic bacteria biofilms formed on medical devices e.g. catheters,FP7,31 December 2014,01 January 2012,2971045.0 NOVOPOLY,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"The goal of NOVOPOLY is the development of new functional materials for pplications in the fields of micro- and nano- systems technology (MEMS and NEMS). Starting point of the proposal is the need to add functionality to existing photostructurable polymers like SU-8 and overcome the current limitations of these systems with respect to mechanical, electrical conductivity and high temperature stability properties. The breakthrough will be the development of novel materials concepts that can meet these challenges. Two approaches will be explored: (i) functionalization of photostructurable polymers (organic) with metal nanoparticles (inorganic), and (ii) the development of novel ceramics from organic-inorganic hybrid precursors. The project focuses on materials design and synthesis, but it also includes processing and structuring issues, and feasibility studies for a few targeted applications. The main output of the project will be polymers and polymer related materials with properties like conductivity, piezoresistivity, Youngs modulus and hardness. These materials will serve as the base for the fabrication of sensors based on micromechanical structures and nanoprobes for biomedical applications as well as for scanning probe microscopy . At the end of the project, a toolbox of materials and processing methods will be available, which will have a considerable impact in the fields of MEMS and NEMS (reduction of cost, simplicity of fabrication and enhanced properties). The consortium unites expertise in polymer chemistry, nanocrystal synthesis, device design and characterization, submicron technology, and manufacturers of new biosensors and SPM probes. NOVOPOLY involves high risks and embryonic research, and combines breakthrough strategies in materials and processing (ink-jet dispensing) with more conventional methods. The knowledge of three SMEs has been incorporated to define specifications and ensure a clear exploitation.",Novel functional polymer materials for MEMS and NEMS applications,FP6,30 April 2008,01 February 2005,1800000.0 NOVOSIP,Aarhus University * Aarhus Universitet,energy,"The project aims at exploring the use of nanovoids and nanodots prepared as plasmonic structures to enhance the efficiency of Si single-crystalline photovoltaic (PV) devices. Fabrication and experimental investigation of plasmonic structures in strained Si/SiGe multilayered structures will be carried to enhance light harvesting in solar cells due to both near-field and far-field effects. The main idea behind the production of nanovoids and nanodots is based on the ability of compressively strained thin SiGe alloy layers, incorporated in a Si matrix during epitaxial growth, to collect small-sized molecules (H, He, C) or vacancies, induced by irradiation. Further, thermal treatment results in the formation of nano-voids which are strictly assembled within the strained SiGe layers. The following key processes will be used: Molecular beam epitaxy of strained Si/SiGe/Si structures followed by irradiation with light ions (hydrogen, carbon) and rapid thermal treatment. This structure will then be additionally used as a template for segregation and self-assembling of metallic or carbon nanodots. The fundamental investigations of the structural, optical and electronic properties of the strained Si/SiGe layers will be carried out with a range of available methods for structural, electronical and optical characterization. By placing the nanovoids and nanodots in a highly doped emitter layer close enough to the p-n-junction that the near-fields will extend into the depletion layer, the effects of near-fields will be obtained. This will give a contribution to the electron-hole pair generation, and this will be additional to the far field effects. Being formed periodically, strained layers with self-assembled nanovoids or nanodots will display fundamentally unusual electronic and optical properties. These effects have not previously been experimentally studied in a solar cell configuration. The present system offers a unique configuration for such investigation.",Nano-Voids in Strained Silicon for Plasmonics,FP7,30 June 2014,01 July 2012,318514.0 NOVOSIP,Belarusian State University,energy,"The project aims at exploring the use of nanovoids and nanodots prepared as plasmonic structures to enhance the efficiency of Si single-crystalline photovoltaic (PV) devices. Fabrication and experimental investigation of plasmonic structures in strained Si/SiGe multilayered structures will be carried to enhance light harvesting in solar cells due to both near-field and far-field effects. The main idea behind the production of nanovoids and nanodots is based on the ability of compressively strained thin SiGe alloy layers, incorporated in a Si matrix during epitaxial growth, to collect small-sized molecules (H, He, C) or vacancies, induced by irradiation. Further, thermal treatment results in the formation of nano-voids which are strictly assembled within the strained SiGe layers. The following key processes will be used: Molecular beam epitaxy of strained Si/SiGe/Si structures followed by irradiation with light ions (hydrogen, carbon) and rapid thermal treatment. This structure will then be additionally used as a template for segregation and self-assembling of metallic or carbon nanodots. The fundamental investigations of the structural, optical and electronic properties of the strained Si/SiGe layers will be carried out with a range of available methods for structural, electronical and optical characterization. By placing the nanovoids and nanodots in a highly doped emitter layer close enough to the p-n-junction that the near-fields will extend into the depletion layer, the effects of near-fields will be obtained. This will give a contribution to the electron-hole pair generation, and this will be additional to the far field effects. Being formed periodically, strained layers with self-assembled nanovoids or nanodots will display fundamentally unusual electronic and optical properties. These effects have not previously been experimentally studied in a solar cell configuration. The present system offers a unique configuration for such investigation.",Nano-Voids in Strained Silicon for Plasmonics,FP7,31 August 2015,01 September 2014,15000.0 NOWAL,University of Southampton,information and communications technology,"The goal of this proposal is to assess the viability of silicon-sensitised erbium doped materials systems for optical device applications. Our work will focus on silicon nanoclusters of 2-4 nm diameter that possess novel optical properties, including the ability to efficiently transfer optical excitation to nearby luminescent species. We aim to exploit the optical sensitisation effects of these nanoclusters, which allow us to couple into Er ions far more effectively than is possible in conventional rare earth-doped glasses. The broad absorption spectrum of the nanoclusters and their very large excitation cross-section will enable us to develop planar optical devices that are pumped in a top down configuration using cheap broad-band sources such as LEDs. Compared to the expensive lasers currently used, we stand to achieve a potential 100-fold reduction in pump power costs by deploying LEDs instead, opening the door for such devices to find applications in local area networks. An amplifier in a waveguide geometry can also allow the fabrication of complex integrated optical circuits, and combine them with silicon technology to achieve electro-optical signal conversion. The erbium-doped silicon-rich silica material will be first characterised and the transfer mechanism will be studied; the fabrication parameters will be varied in order to optimise the efficiency and reduce possible excited state absorption processes. Then, channel waveguides will be characterised (optical gain, scattering, absorption...) under different pumping conditions. The final aim of the project is to demonstrate LED-pumped waveguide amplifiers and lasers in the 1.5 micron range.",Nanocluster-sensitised optical waveguide amplifiers and lasers,FP6,30 April 2009,01 May 2007,159613.4 NOWAPHEN,University of Exeter,photonics,"The creation of artificial super-structure in magnetic materials represents an excellent opportunity to modify their spectra of excitations and hence to design novel so called meta-materials with unforeseen properties, functionalities, and applications. Photonic, plasmonic, and phononic crystals and semiconductor superlattices are typical examples of exploitation of this concept for controlling light, acoustic wave and electron propagation and scattering in electronic and opto-electronic devices. However, the use of magnetic materials with periodically modulated properties offers two obvious additional benefits. Firstly, they facilitate creation of magnetic field controlled non-volatile electromagnetic devices. Secondly, they facilitate exploitation of the intrinsic excitations of magnetic materials -spin waves (magnons). Hence, significant international research efforts are now devoted to the areas of magneto-photonics and magnonics, respectively. The proposed academic exchange aims to establish and support multilateral transfer of knowledge and expertise among several European and international research teams striving to advance the aforementioned research fields.",Novel Wave Phenomena in Magnetic Nanostructures,FP7,02 May 2014,03 May 2010,333000.0 NP-DNA-NDDS,University of Leeds,health,"Cancer is a leading cause of death worldwide, accounting for 7.6 million deaths in 2008. Although conventional cancer chemotherapy can provide profound benefits, seriously adverse side-effects still cannot be avoided, due to lack of specific targeting nature of current treatments. Nanomedicine can reduce such side-effects by exploiting characteristic properties of tumors for targeted delivery and therapy. Despite extensive research, most nanomedicines developed so far have relied on passive targeting using a single therapeutic modality, which are inefficient for treatment of challenging conditions such as multi-drug resistance. Recently we developed a pH-responsive-DNA-GNP conjugate based nanocarrier that numerous features required for an ideal drug nanocarrier, e.g. uniform small nanoscale size, resisting non-specific adsorption, non-toxic, biocompatible, water-soluble, stable, and having high drug loading and controlled release capacities. It can offer efficient and pH-triggered drug release suitable for effective cancer chemotherapy at the cellular level using doxorubicin, a widely used chemotherapy drug. Herein we will extend it into a more effective, multifunctional nanomedicine that can offer simultaneous biomodal chemotherapies with hyperthermia and MRI imaging capacities. First, we will prepare, characterize, and evaluate their drug loading & release profiles in buffer; then we will study and quantify their cell- & cell-specific- uptake and drug delivery efficiency, and then evaluate their toxicity, cytotoxicity & cell-specific cytotoxicity with cancer cells (incoming phase), and finally evaluate their synergistic therapeutic efficacy at cellular and preclinical level (re-integration phase). This project will greatly benefit both the fundamental research in nanomedicine and the healthcare/pharmaceutical indurstries in Europe.",Multifunctional theranostic nanoparticles using pH-responsive DNA-nanoparticle conjugate for effective cancer therapy,FP7,30 September 2015,01 October 2013,309235.0 NPMIMETIC,Stichting VU-VUmc * Foundation VU - VUmc,health,"The intervertebral discs form the elastic part of the spine. It is composed of the annulus fibrosus, a tough outer layer of fibrocartilage, surrounding an elastic gelatinous core, the nucleus pulposus (NP). With age, the water content of the NP decreases, thus, the mechanical loads concentrate on the annulus. This leads to the NP wear, and cracking with a subsequent inflammation reaction and a prolapsed intervertebral disc. The process forms a cycle of accelerated DDD pathology. The 'Gold Standard' for treatment is the 'spinal fusion', an extensive surgery, which blocks definitively free spine motion. Surgeons seek new technologies to allow motion preservation, with long-term outcomes. Based on electrospinning proprietary technology of partner NIC and a novel chemically modified ECM-based biopolymer, developed by partner ProCore, the NPmimetic consortium will develop biomimetic nano-polymer based gel for minimally invasive treatment for disc regeneration: Electrospinning technology will be exploited to design and develop nano-fiber based, biocompatible, biodegradable, synthetic scaffold that will mimic mechanical properties of native NP for immediate and short term treatment. Anti-inflammatory drugs will be carried by biodegradable nano-fibers to be gradually released in situ thus, healing and preventing inflammation. Furthermore, the synthetic scaffold will be integrated with the bioactive-polymer that is highly potent in supporting NP cells for long-term cure. A multidisciplinary study will answer scientific and engineering questions raised by the NPmimetic approach, e.g. hydrogel swelling characteristics, drug delivery, and NP cells reaction to the biomimetic gel environment. All will be supervised by a strong leader in spine surgery to define inputs and outputs of the research, from a clinical implementation point of view.",Biomimetic nano-fiber-based nucleus pulposus regeneration for the treatment of degenerative disc disease,FP7,31 January 2015,01 February 2011,3985587.0 NPS4FM,Aston University,manufacturing,"The ultimate goal of the project is to generate and transfer knowledge on the development of new nanomaterials specifically applicable in novel macro-bacterial sensors for food manufacturing and processing industry. The special structure of nanomaterials gives rise to their amazing properties. The ability to manipulate the structure and composition on the nanoscale provides very large opportunities to create new materials with superior performance for new products and devices. Since the optical properties of nanomaterials can be controlled by changing their size, shape, and aspect ratio, as well as via their surface modification, nanomaterials are prime candidates as building blocks for photonic sensors. The overall objective of this research is to develop the synthesis of ZnO, ZnS and PbS nanostructures with different sizes and morphologies via the laser ablation in liquid technique, then to modify and functionalize the surfaces of the prepared nanostructures and finally to use them for the preparation of photonic sensors with bacteria-detecting properties. Such efficient, easy-to-use and rapid sensors will be evaluated within different food processing, weighing and packaging lines available from project partner. This is an ambitious research programme, with a strong interdisciplinary nature combining materials engineering, surface science, bio-engineering, physics, chemistry and soft matter science. Its success is underpinned by the combination of complementary expertise of the Fellow, Host and Partners in nanomaterial preparation and characterization, photonics and food processing and analysis, respectively. The project will have a positive impact on a longer shelf-life of ready food, monitoring of food manufacturing lines, and optimization of cleaning routine during food manufacturing and packaging. Hence, positive impact on public health sector, as well as economic and ecological effects, is expected.",Nanomaterial Photonic Sensors for Food Manufacturing,FP7,09 February 2016,10 February 2014,309235.0 NRFORHF,Humboldt University of Berlin * Humboldt-Universität zu Berlin,energy,"The project is aimed at developing the nanoscience and technology required for efficient production of hydrogen fuels by using H2O and solar energy as sources. It is basically a laboratory based research work, which includes the design and development of hierarchical Schottky nanostructures (HSNs) and thereby Solar Fuel Cells (SFC) for hydrogen fuels. Today, the realization of technology to harvest the solar radiation into various forms is a crucial and significant task since presently available conventional energy sources are fossil, hazardous and expensive. Recently, nanostructured materials, building blocks of various devices, have received great attention due to their large aspect ratio, surface area and unique physical and chemical properties. In this direction, the proposed project is aimed to develop a new class nanostructures i.e. HSNs and investigate their performance as photocatalyst. Initially, we will develop a high quality HSNs using three-step process: seeding, first order nanostructures (nanorods as stems), and second order hierarchical structures (nanoparticles, nanohairs, nanorods). Then, we will probe the impact of growth conditions on their physical and chemical properties. Finally, the best quality HSNs will be adopted for the development of SFCs and studied their photocatalytic performance as a Nano Reactor for Hydrogen Fuel (NRforHF).",Development of Advanced Renewable Photocatalytic Hydrogen Generation Technology,FP7,30 September 2015,01 October 2013,168794.0 NSHAPE,University of Manchester,transport,"The proposal addresses needs of the European pressure-sensitive adhesive (PSA) industry, which makes an important contribution to Europe's economy and encompasses chemical suppliers, polymer producers, coating companies and end-users. Environmental and health restrictions on emission of organic solvents from industrial processes have driven development of water-borne PSAs (wb-PSAs), which are based on colloidally-stable aqueous dispersions of polymer particles with diameters of 100-400 nanometres and whose composition, internal structure and surfaces can be controlled on dimensions of a few nanometres during synthesis. Due to their socio-economic benefits, there is an increasing demand for wb-PSAs in high performance applications, particularly in the healthcare, aerospace and automotive, construction and assembly, and data tracking industries. A major problem for the PSA industry is that, in comparison to solvent-cast materials, wb-PSAs suffer limitations in adhesive strength and in their ability to bond to non-polar substrates. The proposed work programme will establish, through fundamental research, strategies by which the performance of wb-PSAs can be controlled so that these limitations can be overcome. A key strategy will be to synthesise particles designed to introduce nanometre-scale heterogeneities which are expected to enhance adhesive performance by producing extensive, fine cavitation during debonding. A second, related strategy is to synthesise particles with surfaces that are designed to adsorb at interfaces with substrates in order to increase the strength of adhesion, particularly to non-polar substrates. This fundamental study will inform the development of industrial-scale processes and prototypes for high-performance, commercially-viable wb-PSAs. The academic and industrial participants are drawn from four European countries and offer complementary expertise in polymer synthesis, film characterisation, adhesive #'",Designed Nanoscale Heterogeneities for Controlling Water-Borne Pressure-Sensitive Adhesive Performance,FP6,30 September 2007,01 October 2004,1502044.0 NUCAN,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"The aim of the proposal is to develop a nanoscale toolbox to create smart materials based on the use of natural and artificial nucleic acids. Nanometer sized particles and single (bio)molecules will be connected with restricted and well defined placing to each other and to surfaces. Focus of the proposed STREP is to develop basic building blocks that are capable to arrange by self organisation facilitated by molecular recognition. Complexes generated by nucleic acid directed assembly may be non-periodic and non-regular to combine complex features. Examples of application of such material are incorporated in the project, to direct the development and show the potential of the long term-innovation introduced by NUCAN. Fields of application are bioanalytics, pharmaceutical receptor screening and nanoelectronics. Besides the information content and their dominant role in all life sciences, esp. genetics, nucleic acids have unique properties as polymers and as macromolecules. Both the addressability of each unique site within a given sequence on a nucleic acid strand by base recognition as well as the chemical homogeneity of the polymer through the repeating unit of the backbone makes nucleic acids ideal molecules for the construction of highly ordered but non-periodic supramolecular entities. The aim of the proposal is to develop nanometer scale constructs made of nucleic acids in one, two and three dimensions. Basic principles and development of enabling technologies, detection and production processes are in the focus of the proposal to prepare a basis for applications of nucleic acid based nanoconstructs.",Nucleic Acid Based Nanostructures,FP6,30 June 2008,01 January 2005,2250945.0 NUCLEOPOLY,Rijksuniversiteit Groningen * University of Groningen,health,"With our contributions to DNA block copolymers (DBCs), we have opened a new field of interdisciplinary research at the intersection of polymer chemistry, biology and nanoscience. Within this proposal, we intend to apply our expertise with linear DBCs to new nucleocopolymer architectures ranging from star polymers to DNA networks. Our efforts will not only explore new covalently-bonded polymer topologies but also extend the range of self-assembled supramolecular structures accessible with DBCs. Current progress in this direction has yielded spherical and rod-like DBC micelles. In this proposal we further envisage membranes and vesicles generated by macromolecular DNA amphiphiles. A special focus will be the manipulation of the permeability of these structures by hybridization and the insertion of channel proteins. A major part of the proposal addresses potential applications of DBC architectures in the fields of nucleic acid detection and drug delivery. We will produce selective and sensitive nucleic acid probes employing DBCs with highly emissive conjugated polymer segments or based on novel fluorogenic DNA-templated reactions. Plans for potential delivery systems include the establishment of a DBC-based technology platform to allow combinatorial testing of micelle structures equipped with improved targeting, drug loading and stealth functions. For this purpose, the DNA shell of the nanoscopic aggregates will be exploited for its biological activity in the context of antisense and small interfering RNA activity as well as immune stimulation. Finally, we will employ DBC micelles as programmable nanoreactors within the complex environment of living cells and even carry out sequence-specific organic transformations induced by the cell s own messenger RNA",DNA Block Copolymers: New Architectures and Applications,FP7,31 October 2014,01 November 2009,1500000.0 NUMERIWAVES,Basque Center for Applied Mathematics (BCAM),transport,"This project is aimed at performing a systematic analysis, providing a real breakthough, of the combined effect of wave propagation and numerical discretizations, in order to help in the development of efficient numerical methods mimicking the qualitative properties of continuous waves. This is an important issue for its many applications: irrigation channels, flexible multi-structures, aeronautic optimal design, acoustic noise reduction, electromagnetism, water waves, nonlinear optics, nanomechanics, etc. The superposition of the present state of the art in Partial Differential Equations (PDE) and Numerical Analysis is insufficient to understand the spurious high frequency numerical solutions that the interaction of wave propagation and numerical discretizations generates. There are some fundamental questions, as, for instance, dispersive properties, unique continuation, control and inverse problems, which are by now well understood in the context of PDE through the celebrated Strichartz and Carleman inequalities, but which are unsolved and badly understood for numerical approximation schemes. The aim of this project is to systematically address some of these issues, developing new analytical and numerical tools, which require new significant developments, much beyond the frontiers of classical numerical analysis, to incorporate ideas and tools from Microlocal and Harmonic Analysis. The research to be developed in this project will provide new analytical tools and numerical schemes. Simultaneously, it will contribute to significant progress in some applied fields in which the issues under consideration play a key role. In parallel with the analytical and numerical analysis of these problems, a mathematical simulation platform will be set to perform computer simulations and explore and visualize some of the most relevant and complex phenomena.",New analytical and numerical methods in wave propagation,FP7,01 July 2018,02 January 2010,1662999.8 NUOTO,National Research Council * Consiglio Nazionale delle Ricerche (CNR),manufacturing,"Recently, a new ceramic material, i.e. calcium copper titanate, CaCu3Ti4O12, (CCTO) showed a radically new property, i.e. an impressive dielectric constant k=105 at 1 MHz, which is nearly constant over a wide temperature range (100-400K). We propose to fabricate high capacity density condensers (>500 nF/mm2) for development of a new integrated electronics. It has a huge economic impact (the potential market is billions US$). Many attempts beyond the state of the art are proposed. A nanodescription of the material will be achieved by developing nanocharacterization for a knowledge based activity oriented to material improvement. Pure CCTO bulk properties will be firstly optimized by strongly reducing impurities and anomalies, and then they will be improved beyond the state of the art investigating doped CCTO. We expected that a certain kind of phase composite Ca1+xCu3-xTi4O12 (x=0-3) could decrease the dissipation factor. This activity will produce targets of pure CCTO (first) and then doped CCTO for physical deposition such as laser ablation and sputtering that will be further developed during the project by using novel approaches based on multicomponent deposition. Metal organic chemical vapor deposition development activity guarantees the required high step coverage for use in 3D structures. As a breakthrough, new equipment will be developed within the project for laser assisted Chemical Beam Epitaxy (CBE), which uses a laser to change in situ during the deposition the CCTO composition. The advantage of this approach is the easily scalability to large surfaces for industrial processes. A specific silicon processing (high temperature resistant metal gates, etching,...) will be developed to integrate CCTO deposition in the silicon technology and produce high density planar (2D) capacitive condensers (>500 nF/mm2) working up to 4 GHz. The implementation of 3D structures will allow achieving results that are even more ambitious.",New materials with Ultra high k dielectric constant fOr TOmorrow wireless electronics,FP6,31 October 2009,01 November 2006,2100000.0 NUSIKIMO,Claude Bernard University Lyon 1 * Université Claude Bernard Lyon 1,information and communications technology,"This project is devoted to the mathematical and numerical analysis in statistical physics with a special interest to applications in Plasma Physics and nanotechnology with Micro Electro Mechanical Systems (MEMS). We propose to achieve numerical simulations in plasma physics by fully deterministic methods. Using super-computers, a non stationary collisional plasma can be modelled taking into account Coulombian interactions and self-consistent electromagnetic fields to study different regimes and instabilities. These methods are based on high order and conservative finite volume schemes for the transport and fast multi-grid methods for the treatment of collisions. The first application is the simulation of fast ignition or Inertial Confinement Fusion, which is an important issue in plasma physics. Here, the main difficulty concerns the modelling of collisions of relativistic particles and the development of new algorithms for their treatment. Another part is devoted to the derivation of moments models which require less computational effort but keep the main properties of the initial models. The second application concerns micro and nanotechnologies, which are expected to play a very important role in the development of MEMS. Since the scale of micro flows is often comparable with the molecular mean free path, it is necessary to adopt the point of view of kinetic theory. Then applications of kinetic theory methods to micro flows are becoming very important and an accurate approximation of the Boltzmann equation is a key issue. Even nowadays a deterministic numerical solution of the Boltzmann equation still represents a challenge for scientific computing. Recently, a new class of algorithms based on spectral techniques in the velocity space has been been developed for the trend to equilibrium. The next important step is to treat applications for MEMS in nanotechnology for which the main difficulty is to treat complex geometries and moving boundary problems.",Numerical simulations and analysis of kinetic models - Applications to plasma physics and Nanotechnology,FP7,12 July 2016,01 January 2010,490000.0 NUSIRALS,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"In-line and in-situ fast ultra-sensitive detection of gaseous species at part per billion and part per trillion with ability to distinguish isotopomers without any pre-processing of gas sample is of high interest in chemistry, medicine, geology, physics, various other sciences and industries. Recent technology achievements in development of compact and robust tunable near-infrared and mid-infrared lasers open a door to new applications of optical sensors based upon laser absorption spectrometry. Nowadays, in-situ portable laser sensors based upon direct absorption detection with a mid-infrared quantum cascade laser or a near-infrared diode laser and large volume long path length multi-pass optical cell can compete in accurate isotope-ratio measurements even with ion-mass spectrometers. But in order to reach new horizons significant improvement in sensitivity is necessary. The aim of the project is to develop novel approach of ultra-sensitive gas sensor based upon laser absorption spectrometry and demonstrate absorption sensitivities limited by a shot noise which is caused by the fluctuations of detected photons. The technology based upon frequency modulation of laser, optical locking of the laser to high finesse optical cavity formed by high reflectivity mirrors and signal detection at frequency of free spectral range of the cavity will be developed and tested. We expect to demonstrate highest absorption sensitivities. Laser sensors based upon this technique and mid-infrared and near-infrared lasers will be able to measure molecule concentrations at levels of part per trillion per volume. Robustness and ultra-sensitivity of the developed sensors, knowledge and technology transfer within the project will contribute to widespread implementation of laser sensors in on-line monitoring of impurities in nanotechnology and chemistry, measurements of isotopomers in medicine, geo-science and environmental research, others industrial and social applications.",Novel Ultra-Sensitive Infra-Red Absorption Laser Sensors,FP7,29 February 2012,01 March 2011,121241.0 NW CARDIAC TISSUES,Tel Aviv University,health,"Ischemic heart disease (IHD) is the most common cause of death in the Western world, accounting for more than 741.000 deaths each year in the European Union with yearly costs in excess of € 45 billion. Myocardial infarction (heart attack; MI) captures a significant segment of IHD population and is associated with sudden death as well significant morbidity and mortality. Currently the only cure for end-stage heart failure is cardiac transplantation. As cardiac donors are scarce, there is an urgent need to develop new strategies for regeneration. One experimental approach to treat defected organs is tissue engineering. Engineered cardiac patches to replace scar tissue after MI are produced by seeding cardiac cells within 3D biomaterials. However, success of this approach can be jeopardized by a lack of supporting microenvironment for the organization of a thick tissue and lack of electrical conductivity within the construct, both leading to impaired electrical signal propagation. Another limitation is the lack of an appropriate cell source. In the current proposal we first aim to engineer a 3D microenvironment mimicking the natural ECM of the myocardium. This synthetic matrix will be embedded with gold nanowires to increase electrical signal propagation between cardiac cell bundles. In the second step the ability of this unique microenvironment to support the culture and organization of human cardiac stem cells to a functional mature tissue will be explored. Finally, we will investigate the potential of the nanowired cardiac patch to improve the infarcted heart function. The proposed study has a potential to present a breakthrough in tissue engineering, and could help develop conductive cardiac patches to replace scar tissue after MI and repair congenital heart diseases. Moreover, the approach proposed here could even allow an entirely new strategy to repairing damaged cardiac conduction systems.",Nanowired Scaffolds for Cardiac Tissue Engineering,FP7,31 March 2016,01 April 2012,100000.0 NWS4LIGHT,Lund University * Lunds Universitet,information and communications technology,"The suggested project aims at developing a nanowire (NW) technology applied to III-nitride and III-V materials to improve the present Solid State Lighting (SSL) solutions. Present white light emitting diode (LED) emitters are based on thin film III-nitride technology, and a combination of violet-blue LEDs and suitable phosphor coatings has yielded a light emission efficacy of > 100 lm/W with an operating lifetime > 50000 hrs in commercial white LEDs. The color rendering is generally unsatisfactory, however, and the cost is so far prohibitive for general market penetration.",Nanowires for solid state lighting,FP7,05 July 2017,06 January 2012,0.0 O2SENSE,University of Bath,health,"This programme will employ physical sciences and biomedicine techniques to develop a revolutionary approach to early cancer diagnosis and post-treatment monitoring aiming to address shortcomings in our current technology in oxygen sensing and imaging of hypoxic prostate tumours. This proposal represents a gearing process towards the biomedical implementation of metal complexes and functionalised nanoparticles as novel synthetic platform systems for personalised diagnosis and treatment of diseases such as cancer and which can also be extended to neurodegenerative disorders. The work programme is a meeting point for interdisciplinary science that goes well beyond state of the art. New chemical sensing devices will outstrip and supersede existing biopsy and imaging techniques used in diagnosis and treatment of diseases such as cancers. The key advances of this programme will be: (a) 'smart' all-in-one multimodal imaging probes, whose sensitivities to levels of oxygen in cells (pO2) will be tunable to respond to various levels of hypoxia in tumors as desired. Our ultra-sensitive probes will be effective at low O2 concentrations and respond to reduced levels of hypoxia and under anoxia. This will surpass the mainstay in cancer diagnosis and therapy and provide increased selectivity for a wider range of tumours. (b) new probes suitable for interlocked Positron Emission Tomography (PET), Single Photon Emission Tomography (SPECT), and optical imaging methodologies Simultaneous in vitro and in vivo diagnostic information from radioimaging techniques (PET, SPECT) and optical imaging will provide in depth understanding of biological processes and lead to personalised medicine. (c) new imaging tools for the first time will monitor the cellular biolocalisation of these probes by multiphoton optical imaging in nearIR regimes. These will drive the development of time-gated microscopy and multi-photon imaging with sensitivity for various levels of tumour hypoxia.",Oxygen Sensing with Multimodality Imaging Probes,FP7,31 August 2019,01 September 2014,1886876.0 OA AM,Aberystwyth University,health,"Around a quarter of the European population aged over 60 suffer from disability due to osteoarthritis (OA). The onset, progression, and severity of this degenerative joint disease is crucially influenced and controlled by mechanical factors in the articular cartilage system. Today, the ever-increasing complexity of mathematical models for articular contact mechanics comes in acute contradiction with the scientific striving for clear understanding of the underlying principles of AO pathology. One of the much used ways to simplify mathematical models is asymptotic modelling (AM), which is an asymptotic analysis based mathematical modelling approach to investigate complex multi-parametric and multidimensional systems. This proposal seeks to develop an advanced AM methodology for describing contact mechanics of articular joints under quasi-static, dynamic, and impact loading. The main research objectives are (1) develop elaborate multi-level asymptotic models for analytical evaluation of the sensitivity of the crucial parameters of articular contact mechanics due to small variations in thicknesses and biophysical microstructural properties of the contacting articular cartilage layers, including microcracking in articular calcified cartilage and OA-associated changes in the underlying bone tissue; (2) develop mathematical and computational models for time-dependent nanoindentation of articular cartilage suitable for a new recently emerged methodology for in situ health monitoring of articular cartilage and early detection of OA using indentation type atomic force microscopy; (3) implement the expected results of mathematical modelling and asymptotic analysis into computational simulation software. The proposed mathematical modelling project is intended to be carried out in close collaboration with the biomechanics research group, which has already established links with the target population of patients suffering from OA and the clinicians treating them.",Articular Contact Mechanics with Application to Early Diagnosis of Osteoarthritis: Asymptotic Modelling of Biomechanical Contact Phenomena Under Dynamic and Impact Loading,FP7,31 August 2012,01 September 2010,231089.0 OASIS,Imperial College London,photonics,"The realisation that modulated light pulses can be confined over long distances with minimum losses within a structure that comprises a controlled spatial distribution of the refractive index n -as, e.g. in optical fibres -has, without doubt, underpinned the telecommunications revolution witnessed during the 20th century. The refractive index n, quantifying how light propagates in a given medium, has as a consequence become one of the most important materials properties in designing photonics products. The other key information for most optical and photonic applications is to know how much light is absorbed by a material. This is described by the extinction coefficient κ. There is, though, an apparent lack of solution-processable systems of κ close to 0 (i.e. are transparent) whilst n can be manipulated over a broad window -a bottleneck that has rendered fabrication of a range of optical structures impracticable, if not impossible. Here we address this issue and advance versatile, solution-processable polymer/inorganic hybrids whose refractive index n can be tuned over a wide range without compromising their transparency nor processability. The programme will develop in three directions: i) the design of novel, solution-processable molecular hybrids; ii) the development of (nano-)fabrication technologies for the deposition and/or patterning of such hybrids; and iii) extension of the range of currently explored photonic crystals to entirely new optical devices. Hence, we have identified a clear need for new materials with increased optical functionalities, and novel concepts and approaches that will allow simple fabrication of structures to light. Key objective for the proposed programme thus is to advance new hybrids, develop a deeper understanding of key structure-property interrelationships of inorganic/organic hybrids and develop novel photonic architectures.",Organic/inorganic hybrids for solution-processable photonic structures,FP7,30 September 2016,01 October 2011,1242478.0 ODEON,University of Rome Tor Vergata * Università degli Studi di Roma Tor Vergata,photonics,"ODEON project aims at developing innovative multifunctional nano-materials optoelectronicdevices. The research will be carried out on design, synthesis and fabrication of an interfero metricelectro-optical modulator demonstrator.Electro-optical modulators are key devices in telecommunication. They encode data into an optical signal to transmit over fiber optic cables. Today's available devices are based on lithium niobate.They present intrinsic limitations in the modulation frequency and high production costs.Exploitation of active organic molecules connected to polymers can represent a convenient alternative strategy. First trials on these materials suggest that the drawbacks of the present technology can be overcome.We plan to fabricate a demonstrator device based on new organic chromophores with strong hyperpolarizability, specially designed and synthesized. The chromophores will be hosted in, or grafted on, polymeric matrices and hybrid solgel-derived glasses. They will be manipulated at nanometric scale by means of electric or light fields in order to obtain suitably oriented molecular arrays. These materials will be patterned using different techniques to produce simple waveguiding structures, to test interferometric geometry suitable for the planned electro-optic device. In order to attain our target, a deep insight into chemical and physical phenomena relating to nano-engineering of innovative multifunctional materials is needed. For this purpose, proper characterization of structural, mechanical, linear and nonlinear optical properties will be performed. As final project stage appropriate functional experiments will be carried out to test the demonstrator.High level of competence and complementarities of partners' alongwith the presence of two industrial partners are going to ensure a success and achievement of the objectives. Moreover, the expertise of a leading company operating on the optoelectronic device market, together with innovative materials#'",Design and Fabrication of Optoelectronic DEvices Based on Innovative Second-Order Non Linear Organic Nanomaterials,FP6,31 July 2007,01 February 2004,2625000.0 OFB-SCI,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Harnessing the power of the immune system to fight malignancies remains a challenging goal although important progress has recently been achieved. For example, cancer remission of terminal leukemia patients was accomplished with genetically modified autologous T cells (Dr. June, University of Pennsylvania, 2011). However, these adoptive T cell therapies are limited by the availability of target specific T cells that are extracted from each patient, expanded ex vivo, and transferred back to the patient. To extend cancer immunotherapies to clinics, the current T cell expansion technologies need to be improved to efficiently produce the large amounts of T cells that are required. To overcome this problem we propose the development of orthogonally functionalized binary nanopatterned polymeric substrates that will act as efficient artificial 'T cell proliferation machines'. These binary nanopatterns will consist of gold and oxide nanoparticles that will be orthogonally functionalized with either anti-CD3 or anti-CD28, which are the biomolecules that trigger T cells and activate their expansion. These substrates will introduce an unprecedented fine control in the nanoscale that will certainly contribute to the understanding of the immune processes that remain enigmatic in spite of their fundamental role in the survival of species. The OFB-SCI project proposes a truly multidisciplinary and intersectorial research in the field of Cancer Nanotechnology with a clear ambition to transfer the knowledge acquired to the industry in the near-future facilitating the introduction of novel cancer immunotherapies in clinics. Overall, this project will offer a first class training experience to a promising young European researcher, Dr. Guasch, based on a broad and challenging yet feasible program carefully embedded in a genuine interdisciplinary environment such as Prof. Spatz's group at the Max Planck Institute for Intelligent Systems and the University of Heidelberg (Germany).",Orthogonally Functionalized Binary Nanopatterned Polymeric Substrates for T cell activation and proliferation in Cancer Immunotherapy,FP7,31 March 2015,01 April 2013,161968.0 OFSPIN,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"To ensure the long-term advancement of information technology, radically new concepts, materials and processing methods are required to circumvent the fundamental limitations of traditional, silicon-based electronics. One of the most promising approaches is to explicitly exploit the spin of charge carriers in spin electronics, or spintronics. In this rapidly expanding field, there is a strong need for the development of novel, multifunctional materials and (hybrid) heterostructures with desirable magnetic and transport properties. Organic semiconductors, which form the basis of the by now well established field of organic electronics, are especially promising for spintronics applications, not in the least due to the low spin-scattering amplitudes attainable in these materials. As we learned from the development of organic electronics, understanding and tuning the properties of hybrid inorganic-organic interfaces is of fundamental importance for the optimization of device performance and stability. OFSPIN specifically aims at the development of new knowledge in the field of organic-inorganic based multifunctional materials combining unusual magnetic, electric and optical properties. This proposal is strongly motivated by the recent results obtained in the field of Organic Spintronics, were the pioneering role of Europe was established by two of the presenting partners in OFSPIN. The project will build the knowledge foundations necessary for the development of an interdisciplinary technology based on novel organic and inorganic functional materials, that will evolve into a sustainable technological platform for spintronics and quantum computing.",Organic-Ferromagnetic Hybrid Interfaces for Spintronic Applications,FP6,30 September 2009,01 October 2006,1799979.0 OLAQUI,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"A system of neutral atoms stored in an optical lattice is a promising candidate for implementing scalable quantum computing. A quantum phase transition can be used to prepare exactly one atom per lattice site, where each atom can be considered as quantum bit. Based on the so-called Mott-Insulator state several schemes for quantum computation have been proposed, including proposals for the creation of entanglement, computation with cluster states and quantum simulations. It is planned to use a Mott insulator as a quantum register, in which one can encode qu-bits in the single atoms on each lattice site and quantum gates can be implemented acting on different atoms of the lattice. Crucial advantages are: the simple quantum-level structures of atoms; the insulation from the environment which leads to a strong suppression of decoherence, and the ability to trap and act on a very large ensemble of identical atoms. An impressive example of the flexibility is the use of the internal degrees of freedom of the neutral atoms in order to generate the quantum entanglement essential of many quantum information protocols. To generate entanglement, one requires an experimental system that can be prepared in a pure atomic state, with significant and coherently controlled interactions between the particles composing the pure state. Bose-Einstein condensates fulfil these requirements. The goal is to make quantum processing viable by using neutral atoms trapped in optical lattices. We will focus on different challenges: preparation and initialisation of a quantum register; addressing, manipulating and measuring on single sites; two-bit gates and compatible stable qubits; generation and characterisation of multi-particle entanglement states; strategies for minimising decoherence; quantum simulator; new theoretical strategies for quantum computers with optical lattices. The final objectives of the project will provide a persistent and long-term commitment to emerging applications.",Optical Lattices and Quantum Information,FP6,31 July 2008,31 January 2005,1800000.0 OLAS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The present project aims at achieving foundational research on a world prime: an Organic Electrically Pumped Laser. Our novel approach is based on the engineering of organic heterojunctions in field-effect devices. On the way to realising the main objective, intermediate results and milestones represent by themselves important sub-objectives: 1. Field-effect device with high electron and hole mobility for organic integrated circuits. 2. High brightness light-emitting organic semiconductor device. The strategy proposed to reach the ambitious goal focuses on solving the main difficulties, which are commonly faced when targeting this breakthrough: exciton quenching and photon losses. We take advantage of the know-how developed on ambipolar light-emitting field-effect devices with lateral charge injection to explore unprecedented routes towards the electrically pumped organic laser. This novel approach combines the use of high-mobility (field-effect) structures, n- and p-type materials, phosphorescent compounds, the engineering of materials in heterojunctions, as well as of advanced device and photonic technology. The project activity is expected to have a profound impact on IST-related technologies. Lasers are used daily in a variety of applications. Electrically pumped lasers based on organic semiconductors possess numerous advantages over III-V semiconductor lasers, the most important being the higher integration potential on arbitrary substrates (including glass, polymers and the backend of silicon CMOS), the lower cost and the wider spectral range of possible lasing emission. The realisation of an electrically pumped organic laser would be a breakthrough in both physics of lasers and organic opto-electronics. The research towards this goal is clearly a long-term one, and it contains a very significant risk.",Organic electrically pumped LASer by engineering of heterostructures in field-effect devices,FP6,31 December 2008,31 December 2005,1600000.0 OLLA,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,information and communications technology,"Cold light, i.e. conversion of electrical energy into visible light other than incandescent sources, that allows for high efficiency and fully customized in form, color and appearance has been a dream for long time. The realization is now within reach with Organic Light Emitting Diodes (OLEDs). OLEDs have been researched for 15 years with major emphasis on display applications. Now a certain level of maturity has been reached, such that first products are being introduced in the market. However, the potential of OLED technology is much larger than what has been discovered so far, and ranging far beyond the application in matrix displays. OLEDs have the potential for high efficiencies at high brightness, freedom in shape and color combinations, and a variety of appearances from opaque-white over mirror like to even fully transparent and full tunability in brightness and color. With a number of breakthroughs in materials, optics and production technology, OLEDs could become the ultimate light source for many applications, especially Liquid Crystal Display-backlighting, signage, signaling, advertising and emergency lighting. On the long term OLEDs will become the next generation light sources, replacing in about 10 to 15 years time the currently used incandescent and fluorescent lights. OLLA is the first step towards reaching this goal. To reach this challenging target, project partners will develop new high-efficient materials, research in parallel the most suitable architecture and cost effective processing technology and will build demonstrators, to demonstrate the full spectrum of opportunities with OLEDs. Via the OLLA project, the world-class industrial, institutional and academic partners integrate their resources for R&D, in order to make a fast breakthrough in OLED technology possible, and to be able to bring European OLED applications solutions timely on the world market.",Organic LEDs for ICT and Lighting Applications,FP6,30 June 2008,30 September 2004,1.2E7 OMNI-NET,Opticsvalley-at the service of the Optics of Electronics and Software Engineering in Ile-de-France * Opticsvalley-au service de l'Optique de l'Electronique et de l'Ingenierie Logicielle en Ile-de-France,health,"OMNI-NET aims to provide EU national and regional stakeholders with analysis, methodology, best practice, joint projects and policy recommendations to facilitate the necessary evolution of clusters in transverse and convergent technologies. OMNI-NET focuses on optics and micro/nano electronics (OMN) clusters, relating to IST and NMP technologies. Challenges faced by most technological clusters are convergence and transversality/pervasion. The term convergence applies to technologies that previously belonged to separate fields and are now necessarily combined to meet the demand of end markets. The terms transverse and pervasive apply to technologies that serve a wide range of applicative markets, such as ICT, automotive, aerospace, medical equipment and energy. OMNI-NET aims to foster cooperation between OMN clusters and investigate how they use technological convergence to evolve and serve and/or drive applicative markets, and how this impacts cluster strategy, organisation, communication, equipment and financing. OMNI-NET conclusions will be applicable to a wide range of clusters in convergent technologies such as biotechnology, software, etc., thus contribute to the needs of the EU knowledge economy and industrial dynamics. Existing cluster theory will be adapted to the partners???????? specific experience, with the aim to provide a set of best practice and methodological tools to help regional, national and European policy makers shape new policies in view of the huge opportunities brought by convergence. To provide a set of best practice and methodological tools, OMNI-NET will adapt the existing cluster theory and use experience of other networks such as IRE, Gate2Growth and PAXIS. OMNI-NET outputs will be transferred towards the wider EU innovation community through continuous dissemination, particularly to regions from new member and applicant states. Least, OMNI-NET will prepare an OMN meta-cluster, paving the way for the launch of ambitious joint proj",Opto-Micro-Nano Innovative Network Exploiting Transversality,FP6,24 May 2008,25 November 2005,864364.0 ONCE-CS,The Open University,information and communications technology,"The science of complex systems is crucial to FET and the economic success of Europe. But complex systems research is still not well coordinated in Europe, with urgent need to connect and expand the community. This three-year CA coordinates and integrates scientific research and dissemination in the European CS community by (i) identifying fundamental questions across CS in all areas of application, in order to ground the new science, (ii) encouraging and facilitating research collaboration around the fundamental questions, to stimulate research and applications across academic disciplines, industry and government, (iii) establishing sustainable cross-disciplinary education in CS science, (iv) coordinating the creation of a European PhD in CS science, (v) supporting European Centres of Excellence in CS science, (vi) providing network infrastructure for the new Integrated Projects and connecting them and the CS community, and (vii) coordinating the formation of a vigorous self-sustaining European Complex Systems Society (ECSS), to take over the networking and coordinating roles of Exystence and ONCE-CS. All this is enabled by (viii) the provision of a robust and well-designed Internet portal providing many delivery, retrieval, communication, and management services.",Open Network for Connecting Excellence in Complex Systems,FP6,31 March 2008,30 June 2005,999940.0 ONCOMECHANICS,Consejo Superior De Investigaciones Científicas (CSIC),health,"As a result of the research undertaken in the NANOFORCELLS project (ERC-StG-2011-278860), we have successfully developed instrumentation for the investigation of cell mechanics to discriminate cancer cells from healthy cells by novel physical biomarkers, placing a particular emphasis in the elasticity and viscoelasticity of the cells. In order to accelerate the market entry of the results, the present project will focus on conducting a market feasibility study of the nanomechanical flow cytometer developed, as well as clarifying the IP position strategy and making an initial approach to potential partners and investors. The nanomechanical device to be taken to proof-of-concept, provides label-free classification of cells attending to their volume, mass, density and viscoelasticity. The device is capable of enabling parallel measurements of physical properties of hundreds of individual cells per minute, opening the route for portable tests that would enable determining the health status of cells from blood samples (f.e. leukaemia) based on their mechanical properties. This device will become an ideal tool for the study of drug effects on the physical properties of the cell with research and prognostic value, once made commercially available. The expected outcomes of the PoC project will be an increased understanding of the target markets and the definition of a commercialization roadmap to exploit the device. We envision that research groups within this biomedical field would be a first target market for the product use. The work undertaken so far requires further investment in order to bring the laboratory device to a marketable device and turn the outputs of the NANOFORCELLS project into a commercial proposition.",Commercialization of a nanomechanical flow cytometer for cell pre-screening,FP7,31 May 2015,01 June 2014,149993.0 ONCONANOBBB,Technological Educational Institute of Athens,health,"The partners wish to build a long term European, Industry-Academia consortium, to work on the problem of delivering therapeutic agents, e.g. for brain cancer, across the blood-brain barrier (BBB) at the efficacious dose. Current treatment options for brain cancer are limited with patients having a poor prognosis. One of the major hurdles is the BBB which prevents effective doses of drugs reaching the site of disease. There is thus a major need for technologies that can successfully overcome such a hurdle without having a negative effect on safety and tolerability. Pharmidex have developed a drug delivery system that transiently and reversibly opens the BBB to entry of compounds into the brain without inducing tissue injury. It is based on patented lipid-like structures and has been shown to deliver both small molecules and large proteins effectively into the brain. The lead delivery compound for brain cancer appears to be safe and well tolerated on the basis of pre-clinical testing. We initially seek to determine the mechanism of action of the technology for penetrating the BBB; application to different therapeutic agents as well as development of reliable brain cancer animal models to quantify efficacy of nanoparticle-based therapy using imaging technology. We believe this novel delivery technology will be a unique drug discovery tool with the potential to enhance efficacy of established agents, reduce systemic exposure of the chemotherapeutic agent, thus minimising both the on/off-target toxicity through enhancement of drug absorption at the target site. Besides its scientific objectives, OncoNanoBBB will provide a framework for cooperation and knowledge sharing between a pharmaceutical industry and two academic institutions with complementary expertise in project objectives, as well as dissemination of project outcomes.",Development and evaluation of a quantitative imaging technique for assessment of nanoparticle drug delivery across the blood-brain barrier: Applications for brain cancer therapeutics,FP7,31 December 2015,01 January 2012,849958.0 ONDA,University of Modena and Reggio Emilia * Università degli Studi di Modena e Reggio Emilia,information and communications technology,"Present project aims at strengthening the research cooperation between EU and Russia in the strategic field of ultrathin nanostructured dielectric materials for advanced electronic applications. This field is experiencing a continuous expansion, due to the wide possible applications, which include, among others, enhanced-performance data storage devices, catalysis, communication technologies, sensoristics and molecular electronics. Russia is a leading country in frontier research in this highly relevant technological area, and we believe that through this project the role of EU can be highly reinforced. This will be achieved through the joint participation of EU and Russian researchers in common experiments and related activities. The exchange programme will involve 7 independent partners, 5 located in EU and 2 in Russia and will have the duration of 4 years. The different partners are: 1. UNIMORE – University of Modena and Reggio Emilia (Italy) - project coordinator 2. INC – Institut Català de Nanotecnologia (Spain) 3. IMDEA – Nanociencia (Spain) 4. ESRF – European Synchrotron Radiation facility (France) 5. ILL – Institut Laue Langevin (France) 6. IOFFE – Ioffe Physical-Technical Institute, St. Petersburg (Russia) 7. PNPI – Petersburg Nuclear Physics Institute (Russia) The exchange will concern: i) the preparation and conduction of joint experiments; ii) the discussion of the results; iii) the transfer of knowledge between partners, in relation to specific expertise of individual partners; iv) the periodic organization of workshops and seminars to present the results and identify future activities - common strategies; v) the training of technical staff and researchers; vi) the creation of a research network between EU participating countries and Russian institutions in the field of the experimental investigation of hetero- and ordered nano-structures on dielectrics; vii) dissemination of the results not only within the network but also outside.",Ordered hetero- and Nano-structures with Epitaxial Dielectrics for magnetic and electronics Applications,FP7,06 February 2015,06 March 2011,201600.0 ONE-P,Free University of Brussels * Université Libre de Bruxelles,health,"The call 4.2.2-1 'organic materials for electronics and photonics' is based on the observation that the limited availability of high-performance multi-functional materials is a roadblock to further industrial progress. To address the wide scope of the call, we have identified specific materials bottlenecks to the fields of electronics and photonics. They constitute the focal points of our project. One-P main objective is: 'to invent, design, synthesize, characterize, process, and to supply the missing materials in the fields of organic electronics and photonics and to develop appropriate patterning methods for micro- and nano-structuring of these materials that can be up-scaled to roll-to-roll technologies'. The work plan is composed of five technical workpackages, each one addressing current materials challenges: 1) charge transport and injection, 2) detection and sensing, 3) light emission, 4) functional self-assembled monolayers, 5) continuous processing and technology. Computer-aided design of materials and the use of advanced characterization tools are transversal activities that are integrated in technical workpackages. The sixth workpackage is devoted to dissemination, exploitation, and management of intellectual properties that are essential for the project success. To carry out this multi-disciplinary project, a cross-sectorial consortium has been formed at the European level. It is composed of strong academic and industrial teams with necessary and complementary expertises to cover all scientific, technological and exploitation aspects. The project will generate fundamental knowledge and help to develop unprecedented technologies. They will have a positive impact on competitiveness of European industries, environment, job creation, health, security, safety, and welfare of European citizens","Organic Nanomaterials for Electronics and Photonics: Design, Synthesis, Characterization, Processing, Fabrication and Applications",FP7,31 December 2011,01 January 2009,1.7989814E7 OPEN TOK,Rovira i Virgili University * Universitat Rovira i Virgili,information and communications technology,"This project aims to strengthen the formation of new research lines in the area of porous materials at the Universitat Rovira i Virgili (Spain). The goal is to create a center, where the synthesis-structure-function relationship of carbon-based porous materials for gas storage, and porous membranes for gas and liquid separations, will be studied. New and emerging technologies relay on porous materials because their importance in separations, catalysis, as scaffolds for tissue growth, nanoelectronics, sensors, etc. To reach this goal, we have assembled a multidisciplinary team of researchers, with expertise in materials synthesis, electro-hydrodynamics, surface characterization, and molecular modelling. The project will consist on a knowledge acquisition stage, where staff from the home institution will be trained at world class institutions, followed by the implementation, at the home institution, of the techniques and methodologies learned.",On Process and Engineering of Nanoporous Materials,FP6,28 February 2010,01 March 2006,722327.98 OPENNET,Faculty of Sciences and Technology of the University of Coimbra * Faculdade de Ciências e Tecnologia da Universidade de Coimbra,information and communications technology,"The telecommunications industry has embraced the Internet Protocol (IP) as the vehicle for the new worldwide communication infrastructures. This is evident in the movement of the new wireless and wire-line sectors towards a replacement of the PSTN, the increasing penetration of new Internet services (VoIP, IPTV) and the directions being taken in the 3G and 4G wireless businesses. The main barrier to a fuller-scale deployment is the lack of predictable support for QoS, when packets have to cross many domains. The pace of investigation into this topic is increasing, and the objective of OpenNet is to involve Europe more strongly in the discussions towards finding a solution. The project will focus on defining world-wide the QoS parameter values for Premium IP services on the key interfaces between the market players in a Premium Internet environment. These are the Client-Network Interface (CNI) and the Inter-Carrier Interface (ICI). The technical approach is to bring together the major Internet router manufacturers worldwide (Cisco, Juniper) and to organise workshops together with other parties, especially from the worldwide IPSphere Initiative, in order to agree the parameters and values that are appropriate for the multiple services that are carried across these interfaces. The benefit will be the avoidance of the current situation where every ISP has to make individual interconnection contracts with its peers, which will often be using incompatible bundles of QoS definitions for delay, delay variation and loss. This existing scheme is not scalable, and impossible to use to manage end to end QoS when several domains are crossed. The output will be reflected in Internet Drafts. It is only with such a specification that ISPs can be confident of offering their customers Premium Services end-to-end across multiple networks. The work will also complement the following recommendations from ITU: G.1010, Y.1540, Y.1541.",Open Interconnect for the Internet Community,FP6,31 May 2008,31 May 2006,348000.0 OPHIS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Osteoarthritis (OA) and osteoporosis (OP) are disabling, degenerative bone diseases with significant economic and societal impacts. The incidence of these conditions increases with age but in recent years the number of younger patients has increased, due mainly to factors related to modern life-styles. The efficiency of current pharmacologic and implant-based solutions are limited and often poorly tolerated. OPHIS aims to develop new, engineered biomaterials for the regeneration of both the osteo-chondral region and the vertebral body degenerated by OA and OP. These devices will be based on the unique combination of biological triggers in the form of (i) nanostructured biomaterials able to mimic the extracellular matrices of either bone or cartilage (ii) chemical and biochemical cues able to direct, control and preserve the phenotypes of the relevant cells in their respective histological compartments. OPHIS will explore the frontiers of knowledge of the effect of nano-structures on tissue regeneration and lead to the de-novo design of active structures able to trigger this process. User friendly and highly performing tissue substitutes will be developed as both acellular and cellular matrices for the regeneration of specific anatomical regions compromised by OA and OP. Focus will also be given to the study of the interactions occurring at nano-scale level between the implanted materials and the natural tissues. This information will complement the body of data obtained through clinically reflective in vitro and in vivo models. Dissemination will be integrated step-wise with the strategy for intellectual property protection and exploitation.",COMPOSITE PHENOTYPIC TRIGGERS FOR BONE AND CARTILAGE REPAIR,FP7,31 August 2014,01 September 2010,3939708.0 OPSA,Institute of Physics * Institut za fiziku,environment,"The aim of this project is to improve the level of scientific and technological research in the Centre for Solid State Physics and New Materials (Institute of Physics) in order to become the Centre of Excellence for Optical Spectroscopy Applications (OPSA) in Physics, Material Science and Environmental Protection. The OPSA Centre should contribute to tightening the existing and establishing new links with European Centres in the field of applications of the advanced spectroscopy techniques in diverse fields of the natural science, through the vigorous exchange of scientists between OPSA Centre and European Institutes and Universities, international workshops and training of young scientists. This Centre offers its advanced experimental and theoretical tools: A family of optical spectroscopy methods for studies of condensed matter with particular emphasis on optical phenomena in solid state, defects in semiconductors and insulators, low dimensional structures, nano-crystals; i. e.: -The high resolution Fourier Transform far-infrared and infrared transmission and reflection spectroscopy.? -The photoluminescence and Raman spectroscopy at low and high temperatures under high pressure in a diamond anvil cell, and high magnetic fields. We expect from this project to improve the current experimental techniques concerning the sensitivity and resolution, thus bringing this equipment to European level. By making the OPSA Centre of excellence in the Balkan region we expect to be capable of cooperating in the future programs of European Community. Besides, through the education and training of young researchers in European laboratories, special courses in OPSA and using modern equipment in research, we expect to expand the front of excellence to the west Balkan countries, keeping the experts in the region and broadening perspectives for high level education, research and ability of employment of the young people","Centre of Excellence for Optical Spectroscopy Applications in Physics, Material Science and Environmental Protection",FP6,30 June 2009,01 July 2006,400000.0 OPTIMISE,Imperial College London,health,"With the clinical drive for earlier detection of disease and minimally invasive treatment, there is a paradigm shift of imaging and therapy towards in vivo, in situ surgery. One major effort towards this goal is the translation of emerging optical diagnostic imaging and therapy techniques into minimally invasive surgery (MIS) and cancer screening. This proposal will develop a novel multimodal platform that can be deployed in flexible endoscopy and robotic assisted MIS devices. This is timely in that recently there have been advances in the optical detection of diseased tissue states and also in nanotechnology that allows photothermal therapies based on focused optical energy delivery to gold nanoparticles. The clinical integration of these two strands of research offers significant promise for optical adjuvant cancer therapies and for image-guided tissue fusion, but the study of the therapeutic effect of these techniques has been limited due to the lack of a common platform for image-guided optical follow-up of the therapy. The purpose of this proposal is to develop a programmable light source for simultaneous multimodal screening and image-guided nanoparticle-mediated thermal therapy. The platform will be validated by studying of diseases of the colon to enable detection and treatment of flat polyps that may develop into invasive cancers. As a young lecturer, Dr Elson has extensive multidisciplinary experience in laser technology, biophotonics, optical imaging, microscope technique development, minimally invasive surgery and robotic-assisted surgery. He will bring together new technology with a mix of engineering, biochemistry and biophotonics skills. The proposed work will be carried out in state-of-the-art facilities with access to the clinic for translation.",Optical Platform for Therapy and diagnostic Imaging in Minimally Invasive Surgical Endoscopy,FP7,30 September 2015,01 December 2009,1616146.0 OPTODNPCONTROL,IMEP-LAHC Laboratory,information and communications technology,"Carrier spin states in semiconductor nano-structures can be manipulated with fast optical pulses via the optical selection rules. The electron and hole spins in quantum dots interact strongly with the nuclear spins in the host material via the hyperfine interaction. This allows a new, versatile approach to nuclear spintronics, namely applying fast optical initialisation to carrier states and subsequent transfer via dynamic nuclear polarisation (DNP) of the spin information onto long-lived nuclear spin states, with promising applications in quantum information science and novel nuclear magnetic resonance (NMR) techniques.",Optically controlled carrier and Nuclear spintronics: towards nano-scale memory and imaging applications,FP7,01 July 2020,02 January 2013,0.0 OPTOELECTRONIC_DCA,Technische Universiteit Delft * Delft University of Technology,energy,"Electronically conducting organic materials could potentially revolutionize future opto-electronic technologies, because they are tunable at the molecular level, easily processable, cheap, mechanically flexible, and can form nanoscale structures through bottom-up supramolecular self-assembly. The combination of organic synthesis and supramolecular chemistry can play a crucial role in attaining all these goals, providing a gateway to structures of a high complexity at length scales where both classical organic synthesis and top-down engineering break down. Here, I propose a new approach to making semiconducting nanoscale structures with tunable properties through self-assembly of graphene subcomponents. Graphene, a flat, one-atom thick sheet of graphite, is likely to play a crucial role in nanotechnology, potentially replacing silicon in future electronic devices. Graphenoids have a tendency to form columnar superstructures leading to large conductivities and other interesting optoelectronic properties. The aim of this project is to synthesize graphenoids that are capable of forming reversible covalent bonds amongst each other, and study their hierarchal self-assembly into well-defined, large, multicomponent conducting organic structures through dynamic combinatorial assembly and subsequent directional aggregation. These graphene nanostructures will be studied using state-of-the-art techniques, and their device performance, in for instance solar cells or LEDs, will be investigated. It is expected that these nano-engineered materials will show improved performance stemming from their nano-scale order, functionalization and compartmentalization. By funding European nanoscience and knowledge-based multifunctional materials research, one of the priority themes of the Work Programme, this fellowship will contribute to enhance scientific excellence in the European Union and it will be a first and crucial step towards reintegration of a talented young European researcher.",Advanced optoelectronic materials through dynamic combinatorial assembly,FP7,30 April 2012,01 May 2009,45000.0 OPTOLABCARD,"IKERLAN, S. Coop",health,"The emergence of new pathogens or variations has created recently severe threats to human health (E.coli O157:H7, SARS, the avian-flu disease). The gravity of the problem resides on the fact that their impact and spreading is growing dramatically due to the ongoing increase in worldwide human mobility in combination with trade in livestock, and food products. However, detecting the source of infection through conventional analytical methods requires complicated and time-consuming protocols. The project aims the development of a quick and low-cost diagnostic device (Lab on a Card) that develops and integrates technology advances in optoelectronics, microfluidic and microbiology, capable to detect, in-situ, DNA pathogens in 15 minutes. The device consists of a hand held base unit and a cartridge or labcard that will carry out a Real Time Polymerase Chain Reaction automatically, from sample preparation to an optical detection. The labcard, made of a photoresist called SU-8, on a plastic film, contains all the disposable components, whereas the base unit includes all the standard electronics and optics. The range of applications is limitless (infectious diseases, flu, tuberculosis, hepatitis, AIDS, cancer, etc). and it will be validated on Salmonellosis and Campylobacter detection. The scenario where this diagnostic device is used covers hospitals, food factories and private homes. Its impact will be enormous, reducing the incidence of infectious illness, and providing EU governments with a certificated tool to quickly monitor and survey the sources of pathogen contamination. An especial emphasis will be applied to develop and use microfabrication processes that are compatible with mass production and low cost of the devices offering a protected and disruptive technology to European enterprises. The successful achievement of this project will open the door for many other analytical miniaturisation to be developed.",Mass Produced Optical Diagnostic Labcards Based on Micro and Nano SU8 Layers,FP6,28 February 2009,28 August 2005,1649901.0 OPTOMECH,University of Vienna * Universität Wien,photonics,"Micro- and nanomechanical resonators are currently receiving enormous interest due to their potential as a new class of quantum systems, with possible impact ranging from the foundations of quantum physics, quantum limited sensing and quantum information processing. A particularly successful system is the optomechanical oscillator, where the radiation pressure of light is used to manipulate and read-out the dynamics of the mechanical system. To date experiments have demonstrated individually each key ingredient for the preparation of optomechanical systems in the quantum regime, however still operating in the classical domain. In this proposal we want to take the field one step further, by increasing the optomechanical coupling strength to a level where single-photon effects become dominant. In this regime, one can exploit the full non-linear character of the interaction. This will be achieved by designing and optimizing optomechanical crystals, a novel system where the photonic and phononic modes are localized in a single device, which have recently been developed by the outgoing host. These systems currently outperform all existing optomechanical devices in coupling strength and are ideal candidates for single-photon quantum optomechanics. Envisioned experiments range from answering fundamental questions in quantum physics to quantum information processing tasks - optomechanical crystals can be engineered on-chip, with the potential for realizing a mass-maufacturable quantum technology. Also, the frequencies of the optomechanical crystals can be designed to allow for ground-state preparation when cooled in a dilution refrigerator, which is an enabling regime for observing quantum effects even with coherent optical input fields. The ideal match of the expertise of the outgoing host and the experienced researcher in quantum optics and (quantum) opto-mechanics will result in ground-breaking new developments in this young and rapidly expanding field.",Quantum opto-mechanics with photonic and phononic crystals,FP7,31 August 2014,01 September 2011,234044.0 OPTOMECH,University of Erlangen-Nuremberg * Friedrich-Alexander-Universität Erlangen-Nürnberg,photonics,"The interaction between light and mechanical motion in nanostructures has become a research topic with significant impact and promise recently. This rapidly developing area at the intersection between nanophysics and quantum optics is also known as 'cavity optomechanics'. Fundamental investigations in quantum physics and possible applications like ultrasensitive detection of small displacements, forces and masses drive this field. By now, the basic features have been demonstrated in various experiments worldwide during the past five years. These include displacement detection with precisions down to the standard quantum limit, nonlinear dynamics in optomechanical self-oscillations, and cavity-assisted optomechanical laser-cooling of vibrational modes. The concepts involved are general enough to be applicable to a large variety of different setups, extending to variants such as nanomechanical resonators in superconducting microwave circuits and clouds of cold atoms. It is now time to put these basic elements together and investigate the design of structures containing multiple interacting optical and mechanical modes. These could be used to form optomechanical 'circuits' or 'arrays'. Recently demonstrated nanofabricated photonic-phononic crystal structures provide one essential platform in which to realize these ideas. On the applied side, integrated optomechanical circuits might combine several functions, such as detection, amplification and general signal processing, or contribute to quantum information processing by converting information to and from the light field. On the fundamental side, arrays of optomechanical elements could be used to study the collective many-body dynamics (both classical and quantum) of these novel nonequilibrium systems. We propose to explore theoretically these possibilities, providing a guide-line for experiments and thereby unlocking the potential of such devices.",Theory of optomechanical circuits,FP7,31 October 2016,01 November 2011,1499000.0 OPTONANO,Chalmers University of Technology * Chalmers Tekniska Högskola,manufacturing,"Nanostructured functional materials constitute one of the most dynamic and rapidly expanding fields in scienceand technology, which include their use in such diverse areas as materials technology, biotechnonology, energyand environmental technology, electronics, catalytic applications etc. From other side, the increasingly importantrole in biophysics and in life sciences is played by laser spectroscopie methods. The present project challengesone of the most exciting and phenomena rich sub-fields of nano-science and nano-technology (N&N): theinteraction of visible and near visible light with nanostructured materials. It is aimed at fabrication of optically-active synthetic nanostructures for the exploration of sensing mechanisms with biological matter.In the framework of the present project research activity is planned to be concentrated on, firstly, deliberatefabrication of optically-active substrate by means of state-of-the-art nanofabrication techniques (e-beamlithography, colloidal lithography etc.) and, secondly, exploration of obtained optically-active substrates forbiosensing applications. Utilizing shaped metallic nanostructures or arrays of metallic nanostrctures to influencethe fluorescence of biomolecules in close proximity to the surface is planned by tuning surface plasmonresonance energy of formed nanoarchitectures. Controlled positioning of macromolecular species on the pre-fomed nobel metal nanostructures to probe enhanced fluorescence or enhanced quenching, necessary for ultra-sensitive detection scheme, will be performed. Later goal constitutes a demostration of sensitivity of builtarchitectures to the binding events between preformed sensing platform and biomolecular species,complementary to those available in the fabricated synthetic bio-nanoarchitectures.Overall, the results of research activity are expected to contribute substantially in fundamental understanding ofsurface enhancement#",Synthetic Bio-Nanoarchitectures For Enhanced Biosensing Approach,FP6,31 July 2006,01 August 2004,155182.0 OPTONEURO,University Newcastle upon Tyne,health,"The 2003 breakthrough discovery of a nanoscale optically active cation channel, channelrhodopsin-2, made it possible for the first time, to genetically re-engineer neuron cells to be photosensitive. It became possible to stimulate or inhibit individual action potentials at will, without further chemical modification. The capabilities have been demonstrated in a number of recent high profile journals detailing optical-neural control from cell culture to primate models. The light-gated cation channels were discovered and first applied by European researchers. The photonics and optoelectronics sectors, which can provide new stimulation technologies to this field, are additionally, European strengths. Nevertheless, in recent years, the dominant research output in this area has shifted to well-funded US laboratories. This proposal therefore aims to create a consortium to develop an array of ultra bright electronically controlled microLEDs which will provide a truly revolutionary tool for the neuroscience and neurotechnology community. The consortium consists of experts in the field who converge the many disciplines (optics, sophisticated LED fabrication, CMOS flip chip design and bonding, biophysics, molecular biology, neurophysiology) to bear on the complex, and crucial to neuroscience, problem of studying dendritic physiology and neural network dynamics. Advances in the techniques of this field will absolutely be required to further our understanding of brain function. The system we propose to develop will be powerful, sophisticated and at the same time, lead to a commercial spin-out that will provide them at relatively low cost. In the longer term, the tools we develop in this proposal will hasten our long term aims of developing an optogenetic retinal prosthesis.",Optogenetic Neural stimulation platform,FP7,30 March 2014,01 October 2010,2190000.0 OPTSUFET,University of Strasbourg * Universitè de Strasbourg,health,"OPTSUFET aims at enabling cross-disciplinary training and research at the interface between Supramolecular Chemistry, Materials-/Nano-Science, Physics and Electrical Engineering. The overall goal of OPTSUFET is to generate new scientific and technological knowledge by combining supramolecularly engineered nanostructured materials (SENMs), mostly based on organic semiconductors, with tailor-made interfaces incorporating photochemically switchable self-assembled monolayers on substrates and electrodes, for fabricating prototypes of optically tuneable two- (supramolecular wires) and three-terminal devices (field-effect transistors). The training and research objectives of OPTSUFET are: 1. Surface texturing with photoswitchable SAMs: derivatization of electrically conductive/insulating solid substrates and metallic nanostructures with azobenzene SAMs to optically modulate the charge injection at the metal-SENM and dielectric-SENM interface. By controlling the interface chemistry it will allow the tuning of the self-assembly of electroactive molecules at surfaces into pre-programmed supramolecular assemblies. 2. Hierarchical self-organization on textured surface of multifunctional SENMs based on electrically active functionalized carbon-based 1D and 2D nano-objects such as n- and p-type rod-like and discotics (oligo-thiophenes, perylenediimides, hexabenzocoronenes, etc) at surfaces on the functionalized substrates. 3. Nanochemistry and nanoprobes: Scanning probes (AFM, STM, KPFM, C-AFM) quantitative time and space resolved characterization of various physico chemical properties of SENMs, in particular correlation between structural and electronic properties. 4. Fabrication of photoswitchable supramolecular wires and transistors: Measurement of charge mobility, under photochemical modulation, in SENMs two- and three-terminal devices varying systematically the wire's (1) chemical composition, (2) conformation, (3) length and (4) doping.",Optically tuneable supramolecular field-effect transistors,FP7,30 April 2011,01 May 2009,164877.0 ORANOS,Universiteit Twente * Twente University,information and communications technology,"Research on organic spintronics, which is especially promising due to the prospects of exceptionally long spin lifetimes in organic semiconductors, is currently in a critical phase. After a very successful starting period, progress is now being hampered, largely due to a limited understanding of the critical interfacial properties involved. The mechanisms behind the observed spin valve effects remain poorly understood, and unambiguous evidence of spin polarized transport (other than tunnelling) in organic semiconductors is still lacking. The properties of the hybrid inorganic/organic interfaces are of paramount importance for the device behaviour, and are key to solving the puzzle associated with the physics behind the observed magnetoresistance effects. So far a direct link between device characteristics and interfacial properties remains elusive. In this proposal, we pursue a reliable way to address these crucial issues and to guarantee the progress needed to take the field to the next level.",Organic Nanospintronics,FP7,02 April 2019,03 January 2012,0.0 ORBITAL IMAGING,Trinity College Dublin,health,"Scanning Tunneling Microscopy (STM) has become one of the basic techniques for the analysis of surface reconstructions, overlayer growth mechanisms, surface dynamics and chemistry at the atomic scale. STM is used in physics, chemistry and biology for investigation of organic and inorganic nanoobjects. However, the mechanisms of STM image formation are still not completely understood. The proposed project will be focused mainly on two unresolved issues. The first research focus is related to fabrication of functionalized STM probes with well defined electronic (orbital) structure. To control the electronic structure of the STM tip apex, oriented single crystal probes will be used. The second research focus is related to experimental and theoretical studies of the STM tip and surface atoms interaction and the role of different electron orbitals of the both tip and surface atoms in the STM image formation process. The atom-atom interaction at extremely small tunneling gaps as well as distance and bias voltage dependent contribution of separate electron orbitals will be studied experimentally using scanning tunneling microscopy and spectroscopy at room and low temperatures. The experimental data will be analyzed in a conjunction with results of theoretical (density functional theory and tight binding) calculations. The project activity can provide new fundamental understanding of the atomic scale objects and give some keys for controllable probing separate electron orbitals of individual atoms with STM. This can advance the surface analysis methods necessary for development of nanoscience and nanotechnology. The selective orbital imaging capability can allow to reach ultimate spatial resolution, spin sensitivity at the atomic scale and controllable chemical discrimination of atomic species on surfaces using STM that are essential for physics, chemistry, biology, medicine and materials science.",Electron orbital resolution in scanning tunneling microscopy,FP7,11 May 2014,12 November 2012,200041.0 ORBITAL IMAGING,RAS - Institute of Solid State Physics (ISSP),health,"Scanning Tunneling Microscopy (STM) has become one of the basic techniques for the analysis of surface reconstructions, overlayer growth mechanisms, surface dynamics and chemistry at the atomic scale. STM is used in physics, chemistry and biology for investigation of organic and inorganic nanoobjects. However, the mechanisms of STM image formation are still not completely understood. The proposed project will be focused mainly on two unresolved issues. The first research focus is related to fabrication of functionalized STM probes with well defined electronic (orbital) structure. To control the electronic structure of the STM tip apex, oriented single crystal probes will be used. The second research focus is related to experimental and theoretical studies of the STM tip and surface atoms interaction and the role of different electron orbitals of the both tip and surface atoms in the STM image formation process. The atom-atom interaction at extremely small tunneling gaps as well as distance and bias voltage dependent contribution of separate electron orbitals will be studied experimentally using scanning tunneling microscopy and spectroscopy at room and low temperatures. The experimental data will be analyzed in a conjunction with results of theoretical (density functional theory and tight binding) calculations. The project activity can provide new fundamental understanding of the atomic scale objects and give some keys for controllable probing separate electron orbitals of individual atoms with STM. This can advance the surface analysis methods necessary for development of nanoscience and nanotechnology. The selective orbital imaging capability can allow to reach ultimate spatial resolution, spin sensitivity at the atomic scale and controllable chemical discrimination of atomic species on surfaces using STM that are essential for physics, chemistry, biology, medicine and materials science.",Electron orbital resolution in scanning tunneling microscopy,FP7,30 June 2015,01 July 2014,15000.0 ORCA,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,health,"Artificially constructed materials can be designed to shape the propagation of light and can thus exhibit optical characteristics that are not found in nature. With such metamaterials, remarkable optical applications such as cloaking of objects, sensing of molecular environments or the fabrication of perfect lenses that are not bound by optical resolution limits could be realised. However, for metamaterials to operate at visible wavelengths they have to be structured in three dimensions with nanometre precision which currently poses an enormous barrier to their fabrication. By using molecular self-assembly based on the self-recognizing properties of sequence-programmable DNA strands, this barrier will be overcome. After having pioneered the 3D DNA origami method and the creation of DNA-based metamaterials, I propose the following new paths of research: i) Metamaterials that are switchable in electric or magnetic fields and operate at visible or near infrared wavelengths will be designed and produced by DNA self-assembly for the first time. The hypothesis that materials with strong chirality show negative refraction will be tested and optical resonators with dimensions below 100 nm will be generated. ii) The light-shaping characteristics of metal particle helices will be used to detect organic molecules. As most organic molecules are chiral and can be considered as chiral arrangements of multiple dipole elements, it is expected that the organic dipoles couple to the plasmonic dipoles of the metal helices. This in turn will induce changes in the optical activity of the material. In a parallel approach, organic molecules will be used to induce conformational changes in DNA-supported particle assemblies, which will then be detected in their optical response. Both of these fundamentally new detection schemes will allow extremely sensitive detection of biomolecules at visible wavelengths.",Optical Responses Controlled by DNA Assembly,FP7,30 November 2018,01 December 2013,1433840.0 ORGANIC ELECTRONICS,University of Malaga * Universidad de Málaga,energy,"Transparent electronics is an emerging new technology which utilizes 'invisible' electronic and optoelectronics circuits. To obtain these circuits, the transistor building blocks materials: semiconductor, gate dielectric and conductor must be optically transparent, raising a true grand challenge. The great problem is that conventional organic semiconductors strongly absorb in the visible and few exhibit acceptable TFT performance when processed from solution. This makes clear that there are great opportunities to develop high-performance materials for the fabrication of optically transparent, mechanically flexible optoelectronics. The main goals of this project are: - Develop high-performance, solution-processable, optically transparent organic semiconductor and dielectric materials. - Establish/implement solution deposition/printing processes to achieve multilayers materials deposition with high resolution. - Enable fully transparent, flexible, solution-processed organic TFTs and circuits. - Enable transparent displays. - Analyze the key parameters determining the TFT response. To achieve these tasks, we will carry out these technical goals: - Synthesize and/or optimise new high band-gap molecular and polymeric semiconductors based on rylene, oligothiophene and dicyanomethylene-containing cores. - Functionalize high-purity single-wall carbon nanotubes (SWCNTs) with semiconducting surfactants. - Optimize formulations for solution deposition, focusing on spin-coating and ink-jet printing. - Optimization of layer-by-layer self-assembled nanodielectrics (SANDs) to enhance transparency. - Print crosslinked polymeric dielectric materials on optically transparent substrates. - Evaluate materials performance in various TFT structures on glass substrates. - Characterize spectroscopically and quantum-chemically semiconductors and gate dielectrics. In my work programme, partial objectives can also constitute research items themselves, opening new",OPTIMIZATION OF ORGANIC THIN-FILM TRANSISTORS FOR PLASTIC ELECTRONICS: TOWARDS TRANSPARENT COMPONENTS IN NEW DEVICES,FP7,08 February 2013,20 October 2009,237283.0 ORGANOCS,AIT Austrian Institute of Technology GmbH,transport,"Within the Clean Sky JTI, the use of a nanocomposite material for primary structures of a Green Regional Aircraft is going to be thoroughly studied and analysed. The nano-filler modified matrix have a great potential to exhibit high performance in terms of thermal, mechanical and electrical properties. The objective of AIT is to manufacture nanomodified resins to fulfil the requirements of the Clean Sky roadmap. In a first step, nanoparticles will be selected among nanoclays (both cationic and anionic clays), POSS, carbon nanofibres (Vapour Grown Carbon Fibres) and multi-wall carbon nanotubes. Then AIT will benefit of its experience in nanotechnology to set-up the dispersion methods, to produce batches of modified resin (8 different types are planed), to set up the curing parameter, to produce samples and finally, to characterize them. The proposed test campaign will investigate the chemical, physical, morphological, thermal and mechanical properties. The dissemination and exploitation of the result will be assure by the management Team in close communication and collaboration with the ITD leaders and other CS-RTD partners.",Organic-modification tailored to promote the correct interaction between the polymer and the filler,FP7,09 June 2012,01 January 2010,44999.0 ORGANOMETALLICSWITCH,University of Fribourg * Université de Fribourg,information and communications technology,"Considerable effort is currently being devoted to the miniaturization of electronic devices to the nanometer scale, ideally affording systems that operate on a molecular level. Chemist’s contribution to this research area has thus far concentrated on the preparation of organic OR inorganic materials. For example, purely metallic GaAs and GaP nanowires have been constructed for semiconductor applications. While these materials show excellent electron mobility properties, their tuning potential is rather low. In contrast, organic semiconductors such as conjugated oligomers or polymers display promising properties, though their electron carrier properties are intrinsically lower than that of metallic materials. Organometallic species comprising tunable organic ligand moieties and transition metal centers featuring an enhanced electron mobility may combine the advantages of purely inorganic and organic materials and are therefore expected to be particularly useful as molecular units for the fabrication of new electronic devices. The proposed research aims at identifying molecular switches based on mono- and multimetallic complexes and at their implementation in electronically active devices, thus creating intelligent materials. While organometallic chemistry dominates the highly synthetic first part of the project, the characterization and application of self-assemblies in molecular electronics clearly requires an interdisciplinary approach.",metal-carbene complexes for the synthesis of molecular switches and devices,FP7,01 July 2013,02 January 2009,178163.71 ORGANOZYMES,University of Copenhagen * Københavns Universitet,health,"Here is proposed nano-scale synthesis and combinatorial screening of medium sized peptide-transition metal catalyst libraries with the aim of producing libraries for screening highly selective catalysts for development of nano-medicines. The implementation of catalytic molecules as medicines is a new paradigm in treatment that can overcome a number of the difficulties with present drugs. As with real enzymes the enzyme capacity of these catalysts comes from productive and selective binding of the TS of reaction. The aim is to develop enzyme like molecules: Organozymes, characterized by high turnover as well as both high chemo- and high regio-selectivity. Novel ligands for transition metals containing functional groups will be synthesized and incorporated into encoded solid phase combinatorial libraries on bio-compatible resins. Encoding ensures extremely fast and simple structure/activity assessment. The screening of split-mix combinatorial libraries of organozymes will have the distinct purpose of developing of artificial proteases as drugs. This involves e. g. Fe, Zn and Cu peptide complexes and combinatorial FRET-substrate screening for proteolytic activity to identify artificial organozyme proteases that act as nano-medicine towards marker proteins in Alzheimers disease. Nano-container delivery of catalytic drugs to target tissue will be developed.",Nanocatalytic drugs towards Alzheimer's disease,FP7,31 May 2016,01 June 2014,230809.0 ORGELNANOCARBMATER,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"Research in novel energy sources, efficient energy storage, sustainable chemical technology, and smaller microelectronic devices with interfaces for biological systems are among the current challenges in science and technology. Carbonaceous materials and organic electronic materials which speak the language of biomaterials will play a central role in the search for possible solutions. We aim to develop a universal supramolecular approach for their preparation and propose to develop synthetic pathways toward conjugated oligomers carrying hydrogen-bonded substituents, such as oligopeptide-polymer conjugates. These substituents serve as a supramolecular motif promoting the aggregation of the molecular precursors into single crystals, thin films, or soluble one-dimensional nanostructures. The obtained ordered phases or nanostructures from conjugated molecules themselves are highly interesting candidates for applications in photovoltaic, light-emitting, or semiconducting devices. Related nanostructures from oligo(phenylene)s or oligo(ethynylene)s will serve as reactive molecular precursors for a conversion into soluble graphene ribbon nanostructures. Finally, this approach will be extended toward the preparation of carbonaceous materials from amphiphilic oligo(ethynylene)s as energy-rich molecular precursors under preservation of the mesoscopic morphology, surface chemistry, and carbon microstructure. The obtained materials are highly interesting with respect to ion or hydrogen storage, and transition-metal-free catalysis. Hence, this research project aims to combine synthetic organic chemistry, supramolecular chemistry, and materials science in order to both deliver novel materials and improve our understanding in utilizing supramolecular-synthetic methods in their preparation.",A Universal Supramolecular Approach toward Organic Electronic Materials and Nanostructured Carbonaceous Materials from Molecular Precursors,FP7,31 August 2014,01 September 2009,1700000.0 ORGENECHOICE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Odorant receptor (OR) genes form the largest family in the mouse genome: ~1200 genes spread over ~40 loci. Each olfactory sensory neuron (OSN) expresses one OR gene, from one allele. The mechanisms of OR gene choice remain elusive. We will execute five specific aims that are interconnected but independent. We will search for homeodomain genes that we can link functionally to expression of a subset of OR genes; we will define promoter regions for the eight OR genes that are solitary, not belonging to a cluster; we will look for organizational principles among the repertoire of second choices in OSNs that express first an OR locus without a coding sequence; we will characterize the phenotype of mice with a knockout of a novel regulatory element, the P element; and we will test the distance-dependence of the activity of this and a similar element (the H region) by transplanting it within the local genomic region. Guiding hypotheses are that promoter regions for OR genes are short and close to the coding sequence; that the conserved homeodomain and O/E binding sites in OR promoter regions have a fundamental role in OR gene choice, rather than in transcription after it is chosen for expression; and that the H and P elements are two of several similar regulatory elements that each operate in cis within a cluster. The approach is based on gene targeting and transgenesis by pronuclear injection. A multipronged strategy will be taken to assay OR gene expression, with βgal-reporter mice, in situ hybridization, custom Affymetrix microarrays for mouse ORs, quantitative, real-time PCR, and Nanostring molecular bar codes. Understanding OR gene choice will have implications for our understanding of the regulation of gene expression in the mammalian genome -particularly if new mechanisms or principles are discovered.",Regulation of the expression of odorant receptor genes in mouse,FP7,31 March 2015,01 April 2010,2500000.0 ORION,Fundacion Cidetec,energy,"ORION puts together a multidisciplinary consortium of leading European universities, research institutes and industries with the overall goal of advancing the fabrication of inorganic-organic hybrid materials using ionic liquids. Maximum research efforts within ORION will be addressed to achieve inorganic-organic hybrids with an ordered nanostructure and to understand and characterize the new generation of inorganic-organic hybrids. ORION aims to take advantage of the properties of Ionic Liquids as templating supramolecular solvents in the synthesis of novel hybrid materials. Additionally, the use of ILs will bring innovative properties to the hybrid materials due to their intrinsic wide electrochemical window and high ionic conductivity and hence this method will generate radically new materials. The new ordered inorganic-organic hybrids will be morphologically and electrochemically characterized with emphasis on their potential application in batteries, innovative solar cells and gas sensors. By reaching this ambitious goal, ORION will pave the way towards inorganic-organic hybrid products for chemical, materials, energy and sensor industries.",ORDERED INORGANIC-ORGANIC HYBRIDS USING IONIC LIQUIDS FOR EMERGING APPLICATIONS,FP7,30 September 2013,01 October 2009,6896960.0 ORION,Research Center Plast-optica * Centro Ricerche Plast-optica SpA,energy,"The development of renewable energy is a central aim of the EU Commission's energy policy. Concentration PhotoVoltaics (CPV) has been demonstrated to be a good solution in PV industry and in the last years has become more attractive and several companies have been founded with the main goal of decreasing the cost of PV-generated electricity. The main objective of this project is the optimization of materials and technologies involved in CPV System production to reduce system cost/watt and increase system efficiency. The reduction of system cost/watt, that reflects in reduction of PV-generated electricity, will be achieved by: -developing an all-plastic system by using recycled plastic compounds; -developing Si solar cells for automatic assembling technology; -implementing and industrializing automated high-rate technologies for cell assembly and optics production. The increase of system efficiency will be achieved by: -increasing Si concentration cell efficiency by using surface plasmonic crystal structures; -developing plastic materials doped with down-converting nanoparticles for modification of the solar spectrum to enhance the cell efficiency. The scientific objectives concern optimization of Si solar cell and the development of new application-addressed nanocomposite thermoplastic material. Technological objectives concern the implementation and industrialization of automated low-cost technologies for CPV components fabrications. The scientific and technological objectives of the project will be exploited by the realization of a low –CPV system with a projection 2-3 €/Watt . The new system, ready to be produced at the end of the project, will be based on Si concentration solar cell technology coupled to hybrid mirror-lens concentrator optical system. The project also includes the design and development of an innovative one-axis tracker integrated with optics for the realization of a compact and modular CPV system for domestic rooftop applications.","Optimization of Si solar cells, plastic materials and technologies for the development of more efficient concentRatION photovoltaic systems",FP7,31 December 2011,01 October 2008,2233000.0 ORION,Daithi O'Murchu Marine Research Station Ltd.,environment,"Restaurants, hotels, markets, fisheries and other small to medium size agro-food industries have to manage 239 million tonnes of organic waste in Europe per year. The specific management of such waste, with respect to the legislative regulations of EU, involves costly treatment for SMEs and potential hygiene issues on site. ORION aims at allowing a vast majority of SMEs to manage their organic waste by themselves in order to decrease their treatment costs (storage, transport, landfill or incineration) and increase on-site hygiene conditions. Wastes will be also valorised as biomass to produce energy and increase SME autonomy and profitability.",ORganic waste management by a small-scale Innovative automated system of anaerobic digestION,FP7,07 July 2017,08 January 2012,0.0 ORITUPOCO,SAV - Polymer Institute * Ústav polymérov,manufacturing,"Proposal plans to prepare well-aligned carbon nanotube (CNT)/polymer composites. The orientation of CNTs will be reached by two ways. By the first way, well-dispersed surface modified CNTs in gel network will be uniaxially stretched and then cross-linked further, to freeze to the oriented system. By the second way, CNTs with photo-active groups at surface will create self-assembled structures in polymer matrix. For this reason, it is necessary to perform surface modification of CNTs. It will be achieved by introducing of functional groups or oligomers miscible with polymer matrix to reach the best compatibility or by introducing the photo-active groups. Author believes that during self-assembly process of photo-active groups attached at nanotube surface they will induce the orientation of CNTs by light. Similar procedure with photo-active groups can be use in case of alignment by uniaxial stretching. For fixation of anisotropy after stretching the photo-active groups can be used again when oriented structure of CNTs is fixed by photocoupling and/or photocrosslinking at different stage of uniaxial stretching. The photocoupling or photocrosslinking produces strong chemical bonds that fix the internal structure of filler inside matrix. In addition the alignment can be affected by concentration of photo-active groups or used light. An influence of various wavelength, irradiation dose and type of polymer matrix on the orientation of CNTs and influence on mechanical and electrical properties of final CNT/polymer composite will be studied. Various optical, mechanical and electrical methods will be used for characterization of prepared composites. All data will be collected at various irradiation doses in order to be able to determine the photo-actuation behavior of composites.The ambitious goal of the proposal is photo-actuation of prepared CNT/polymer composites associated with new functionalization of CNTs.",Orientation of Carbon Nanotubes in Polymer Composites,FP7,03 July 2014,04 January 2009,45000.0 OSIRIS,iMinds Vzw,information and communications technology,"The OSIRIS consortium is composed of participants involving Public Authorities and RI Champions across 12 EU Members States and Associated Countries and regions with direct links to existing and future ICT European RIs (i.e. High Performance Computing, Grids, Networks, Micro/Nanoelectronics and Future Internet). OSIRIS therefore has been established with the necessary structure and elements to reach its objectives:",Towards an Open and Sustainable ICT Research Infrastructure Strategy,FP7,06 June 2014,01 January 2010,0.0 OSIRIS,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"The OSIRIS proposal will address the crucial and ultimately strategic area for the future emerging nanoelectronics, i.e. how structures and devices actually will be fabricated as physical dimensions approaches a few nanometer minimum feature size. The project title is Open silicon based research platform for emerging devices and indicates that many of the future emerging devices will be based on a silicon fabrication base platform but may not be fully based on silicon as the active semiconductor material. Over the past 10 years this research team has established a versatile fabrication technology platform in excellent condition to open up a variety of new technologies to explore nanometer minimum feature size in realizable electrical repeatable devices structures. The proposed project has five different focus areas outlined. It covers a broad range of critical research issues that can be foreseen as groundbreaking topics for the period beyond 2015. the different topics addressed are; 1) Three dimensional FET nanostructures based on SiNW and GeNW with advanced configuration. 2) New applications of SiNW with build-in strain for fast silicon-base optoelectronic devices. 3) Low frequency noise in advanced nanoelectronic structures 4) THz devices for IR-detection 5) Bio-sensor nanoelectronics for extreme bio-molecule sensitivity and real time detection of DNA. These areas are carefully chosen to assemble the right mix with predictable research success and with a few areas that can be called high gain/high risk. In particular we want to mention that focus area 2 and 4 have a great potential impact when successful but also at a certain higher risk for a more difficult implementation in future devices. There is in no cases any risk that the research will not generate high quality scientific results.",Open silicon based research platform for emerging devices,FP7,31 May 2014,01 June 2009,1999500.0 OTEGS,Linköping University * Linköpings Universitet,energy,"At the moment, there is no viable technology to produce electricity from natural heat sources (T<200°C) and from 50% of the waste heat (electricity production, industries, buildings and transports) stored in large volume of warm fluids (T<200°C). To extract heat from large volumes of fluids, the thermoelectric generators would need to cover large areas in new designed heat exchangers. To develop into a viable technology platform, thermoelectric devices must be fabricated on large areas via low-cost processes. But no thermoelectric material exists for this purpose. Recently, the applicant has discovered that the low-cost conducting polymer poly(ethylene dioxythiophene) possesses a figure-of-merit ZT=0.25 at room temperature. Conducting polymers can be processed from solution, they are flexible and possess an intrinsic low thermal conductivity. This combination of unique properties motivate further investigations to reveal the true potential of organic materials for thermoelectric applications: this is the essence of this project. My goal is to organize an interdisciplinary team of researchers focused on the characterization, understanding, design and fabrication of p- and n-doped organic-based thermoelectric materials; and the demonstration of those materials in organic thermoelectric generators (OTEGs). Firstly, we will create the first generation of efficient organic thermoelectric materials with ZT> 0.8 at room temperature: (i) by optimizing not only the power factor but also the thermal conductivity; (ii) by demonstrating that a large power factor is obtained in inorganic-organic nanocomposites. Secondly, we will optimize thermoelectrochemical cells by considering various types of electrolytes. The research activities proposed are at the cutting edge in material sciences and involve chemical synthesis, interface studies, thermal physics, electrical, electrochemical and structural characterization, device physics. The project is held at Linköping University holding a world leading research in polymer electronics.",Organic Thermoelectric Generators,FP7,31 March 2018,01 April 2013,1453689.0 OXIDE INTERFACES,Imperial College London,energy,"European community is investing many resources into renewable energy research to come off the fossil source dependence and to reduce carbon oxide emissions. Solid Oxide Fuel Cell is one of the more promising solutions thanks to its high energy conversion efficiency and fuel flexibility. The industrial expansion of ionic conductors as commercial devices for energy production, oxygen generation or gas sensors, is related to the development of new electrolyte materials with higher ionic conductivity. Recent investigations have demonstrated an important interface effect in multilayer's thin films with an enhancement of the ionic conductivity of several orders of magnitude. Our project intends to investigate, by a fundamental point of view, the physical and chemical bases that regulate this super ionic behaviour. We propose two different approaches to study this interface effect. The first one consists on designing interfaces parallel to the substrate by multilayer PLD deposition; multilayers will be based on different materials as the mixed ionic electronic conductor La0.9Sr0.1Ga0.8Mg0.2O3-δ, or the δ ï€phase Bi2O3 high oxygen ion conductor. The second one employs a nanolithography method to engineer ionic conductor interfaces perpendicular to the substrate which will be formed by ionic conductor YSZ columns embedded in a second thin film. In both strategies the use of different single crystal substrates will permit to tailor film stress tensile or compressive and the relative interface defect formations. Top class facilities as Titan HTEM and LEIS TOF SIMS will be essential to correlate defect formation, strain and dopant segregation to the interface effect in ionic conductivity enhancement. Nanolithography will be also utilized to design new dense nanocomposite cathodes formed by columns of an ionic conductor set into an electronic conductor thin film. This model system will offer new tools to investigate the interface effect on the cathodes' oxygen reduction reaction",Interface engineering of ionic conductor multilayer and cathode nanocomposite thin film oxides,FP7,31 August 2013,01 September 2011,200549.0 P NANOPARTICLES,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"There are two different aspects in the project: i) the use of P4 in the synthesis of nanocristals of metal-phosphide and ii) fixation and activation of nitrogen and its reduction to organic derivatives. i) Synthesis of nanocrystals MxPy Usually the syntheses of these species imply the thermal decomposition (at high temperature) of a metallic precursor and a P atom donor in the presence of a mixture of a solvent/ligand. Normally P atom donor is TOP ligand. The main objective of our project is the use of more efficient P atom donor like P4. As starting point the synthesis of Ni2P and InP particles would be attempt due the expected properties for them (catalyst for olefine polymerization for Ni2P and optoelectronic and biology for imaging for InP) but the procedure will be extended to other metals like Pd, Pt or Ga. ii) Nitrogen activation The transformation of N2 into nitrogen containing species is a formidable challenge for chemists. The prerequisite for such transformation is the coordination then activation of N2 onto a metal complex. The Haber Bosch process allows the formation of NH3 from N2 an H2 but the conditions employed are quite hard and it is performed on a heterogeneous support. The second part of the project we propose to carry out involves homogeneous metal complexes together with silyl radicals and the use of nanoparticules for N2 activation. We are going to use for homogenous N2 activation a Mo(0) compound stabilized by ligands which would not decompose by the presence of reducing agent. The starting point is the reaction of [Mo(dppe)2(N2)2] with very bulky silyl derivatives to put in evidence the involvement of radicals in the process.",P4 as precursor for metal phosphide nanoparticles and N2 activation and reduction to organic derivatives.,FP7,01 June 2010,02 June 2008,171600.0 P.CEZANNE,Clalit Health Services,health,"Around 8.6% of the western population suffers from type 1 or 2 diabetes and rates are expected to rise due to rapid changes in diet habits. To stabilize their daily condition and allow normal life, diabetic patients must constantly monitor their blood glucose level (BGL) and inject themselves with insulin several times a day. Failure to regulate their blood glucose concentrations and fluctuations in glucose blood level over a long period may be critical and lead to severe secondary complications, such as myocardial infarction, stroke, peripheral vascular disease, kidney diseases, diseases of the nervous system, and retinopathy leading to blindness. All attempts to develop extra-body devices have failed so far for many reasons. The main goal of this project is to provide the medical caregivers with an IST tool that is capable to monitor in real-time the glucose levels of this community. Hence, micro sensors implanted under the skin measuring BGL on a continuous basis seem to be the most suitable solution. The main objectives is to research and develop a novel implantable long-term nano-sensor for continuous BGL monitoring. The nano-sensor will be linked to the wireless device platform of the ICT system and the data will be automatically collected, stored and processed. The novelty of C?ZANNE lies within the nano-sensor containing living cells or proteins, compact capsule with optics and microelectronics that measures continuously to provide physicians with online medical data The processed data will also be used for automatic regulating of the glucose level by linking it to an insulin pump that accurately releases insulin into the body in response to the fluctuations of glucose concentrations. Furthermore, the system design may be applicable to other diseases related to monitoring other medical parameters by changing the biological substrate in the sensor. Such technology will provide better means for monitoring and treating people with diabetes",Development of an Implantable bio-sensor for Continuous Care and Monitoring or Diabetic Patients,FP6,31 December 2010,30 June 2006,8500000.0 P3SENS,Multitel Asbl,manufacturing,"The detection of chemical or biological substances increasingly appears as an essential concern in order to prevent human or animal health and security related problems. Present analytical techniques are expensive and often require highly specialized staff and infrastructures. The principal need is to perform screening tests, which can be carried out in non-specialized infrastructures, e.g. Point of Care, schools and field, before unambiguous identification in a specialized laboratory. There is thus a need to develop a new detection system that has low-cost and is portable but at the same time offers high sensitivity, selectivity and multi-analyte detection from a sample containing various components (e.g. blood, serum, saliva, etc.). The objective of P3SENS is to design, fabricate and validate a multichannel (50 or more) polymer photonic crystal based label-free disposable biosensor allowing for a 'positive/negative' detection scheme of ultra small concentrations of analytes in solution (< 1 ng/mL). The biosensor will be encapsulated in a specifically designed microfluidic system in order to deliver the sample to the multiple sensing zones. The design of the biochip will allow it to be easily inserted in a compact measurement platform, usable by non-specialized practitioners outside of specialized laboratories for carrying simultaneous multi-analyte detection, delivering real-time monitoring, and with an assay duration that will not exceed a few tens of minutes. The photonic chip proposed in this project will be based on polymer Photonic Crystal (PhC) micro-cavities coupled into a planar waveguide optical distribution circuit. The photonic chip will be fabricated with available fabrication technologies - and with an emphasis on low cost substrates (polymer) and fabrication processes (nano-imprint lithography). More generally, P3SENS will push forward the development of low cost disposable biochips based on photonics.",Polymer Photonic multiparametric biochemical SENSor for Point of care diagnostics,FP7,31 December 2012,01 January 2010,2596909.0 PACE,Ruhr University Bochum * Ruhr-Universität Bochum,information and communications technology,"The integrated project PACE will explore the utilization of the simplest technically feasible elementary living units (artificial cells much simpler than current cells) to build evolvable complex information systems. We will create, analyse and investigate the applications of such systems that process information by self-organization starting at molecular scales. We will also determine whether life-like properties are necessary for computational systems to be fully robust and adaptive and investigate the tension between evolvable living autonomy and programmable utilization.. We will explore the collective properties of artificial cells and demonstrate that they are the right material for building nanoscale robot ecologies. The particular molecular systems we will consider will have genetically controlled catalytic reactions, self-assembly of complex supramolecular structures, and energy transduction. We will investigate the stepwise evolution of such complex systems by machine complementation and combinatorial search using a programmable microfluidic interface. We will provide theoretical and simulation frameworks for understanding emergent computational properties of such systems, and experimental frameworks for programming them by evolutionary exploration of chemical reactions. We will integrate and disseminate multidisciplinary European activities to give it a decisive international competitive advantage in this FET.",Programmable Artificial Cell Evolution (PACE),FP6,30 June 2008,30 March 2004,6605000.0 PACMAN,European Organization for Nuclear Research (CERN),transport,"With new accelerators delivering beams always smaller and more energetic, requirements for very precise beam alignment become more and more challenging. After the Large Hadron Collider (LHC) and its planned upgrade, proposed lepton linear colliders require unprecedented tolerances of beam alignment at nanometre level.",A Study on Particle Accelerator Components Metrology and Alignment to the Nanometre scale,FP7,08 July 2019,09 January 2013,0.0 PACOMANEDIA,University College London,information and communications technology,"I propose to investigate two closely connected themes which aim to exploit the full potential of quantum mechanics in information technology. Both the themes concern the exploitation of the nonequilibrium dynamics of many strongly coupled quantum systems which is recently becoming feasible to observe in a plethora of engineered systems. As one broad objective, I plan to examine automata made from a multiple quantum units such as nanomagnets for transporting bits and performing classical (Boolean) reversible logic. In a similar vein, coding of bits in domains of engineered quantum many-body systems and their exploitation for Boolean computing will be explored, as well as examine the quantum nonequilibrium dynamics of a processor which combines transport and processing together. The open nature of the constituent quantum systems will be an integral part of our calculations which will be set in a regime where dissipation (decay of energy from the system) is not significant, though dephasing (loss of quantum coherence) may be substantial. I foresee the advantage of such automata in highly energy efficient and fast computation whose speed is set by the couplings of the quantum many-body system. The second broad objective seeks to overcome a formidable obstacle in the physical implementation of quantum computation, namely the high control demanded on every quantum bit and their interactions with other quantum bits. I plan to offer and investigate an alternative paradigm where the information is processed by harnessing the minimally controlled dynamics of quantum many-body systems. In this context, I will look both at general questions such as to whether a network of interacting spins can serve as an automata for running an entire quantum algorithm, whether magnon wavepackets can be used like photons for linear optics-type quantum computation, as well as the realization of such ideas in a variety of available quantum many-body systems.",Partially Coherent Many-Body Nonequilibrium Dynamics for Information Applications,FP7,09 June 2019,10 January 2012,1245078.0 PAIRSOFBECS,Universiteit van Amsterdam * University of Amsterdam,information and communications technology,"Since their first demonstration in 1995, Bose-Einstein condensâtes have become an attractive tool for further developments in fields as various as integrated atom chips, atomic clocks and quantum computing. Thus, it is important to understand the properties of these condensâtes in detail, and in particular the condensed matter behaviour of their phase properties. We propose to investigate scattering, fusion, and interference of two simultaneously trapped Bose-Einstein condensâtes. The main goal is to study the influence of topological macroscopic excitations - vortices - on the phase coherence phenomena and dynamical properties. The present project focuses on the experimental approach. A direct interaction with the theoretical group in the host institution will help extracting the physical picture of the dissipative dynamics of vortex-antivortex annihilation under these conditions. The work will be done in the 'Quantum Gases' group run by Prof. Dr. J. T. M. Walraven and Prof. Dr. G. V. Shlyapnikov, at AMOLF, Amsterdam. This group has demonstrated its expertise in both experimental and theoretical work on ultra cold gases and Bose Einstein Condensation. The host group has agreed to embed this proposal into their research program. A preliminary experiment has already been done with the experimental apparatus at the host institute, which demonstrates the possibility of driving the collision of two magnetically trapped Bose-Einstein condensâtes. The setup will be upgraded to allow the proposed vortex experiments. Scattering will be studied by driving fast collisions between high-density condensâtes; fusion by slowly colliding high-density condensâtes; interference by overlapping low-density condensâtes. In this setting the applicant will develop high level scientific skills complementary to those he has already developed during his PhD thesis. He will also participate in international conferences and in managing and supervising.","Scattering, fusion and interference of two trapped Bose-Einstein condensates: an investigation of the condensed matter behaviour of degenerate dilute gases",FP6,31 December 2004,01 January 2004,157192.0 PALM TCR COMPLEXES,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"The cell transduces information across its plasma- membrane via the engagement of surface receptors and the subsequent recruitment of intracellular proteins to these receptors or to adapter proteins to form transient and heterogeneous signaling complexes. Multi- molecular signaling complexes can, in turn, be found in large microclusters or aggregates. Such signaling complexes and clusters have been shown to play a crucial role in T cell activation and thus, in the ability of the immune system to adequately respond to foreign pathogens. However, little is known about the detailed structure, content, and organization of signaling complexes due to severe limitations of current experimental techniques. I propose to develop and apply cutting-edge super-resolution microscopy techniques, biophysical models, and statistical methods to study mechanisms of cell activation by signaling complexes in single-molecule detail in intact cells. Previously, by imaging complexes downstream of the T cell receptor at the single- molecule level with photoactivated localization microscopy (PALM), I found that these complexes show functionally significant nano-scale organization at the plasma- membrane of activated cells. I hypothesize that signaling complexes have additional levels of dynamic organization that are crucial to the plurality of functions of these complexes in adequately activating T cells. Importantly, my developed techniques and expected results will be relevant to many other signaling systems and will greatly extend our understanding of the composition, structure, and formation of signaling complexes and mechanisms of cell activation in health and disease. Such knowledge will present novel opportunities for pharmacological intervention in diseases involving inadequate immune responses and in cancer.",Studying the Structure and Dynamics of TCR nucleated Complexes at the single molecule level,FP7,30 September 2016,01 October 2012,100000.0 PALMSEP,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"The septins are a conserved family of GTPases that interact with membranes and the cytoskeleton. Several different septin molecules combine into nonpolar dimeric rods. These rods are thought to assemble end-over-end into higher order structures that orchestrate complex cellular events at the interface of the cytoskeleton and the plasma membrane. In this way, septin complexes organize the cleavage furrow in dividing cells, serve as a corset to maintain cell shape in cell motility, engulf invading bacteria and control the morphological differentiation of nerve cells. The integrity of the complexes is essential for septin function. However, the architecture of septin complexes and the rules guiding their assembly, while seemingly conserved from yeast to mammals, are not clear. The main objective of this study is thus to understand the rules controlling the assembly of septin complexes from subunit rods in yeast and mammals and to find out, whether there are alternative models to end-over-end assembly of septin rods into complexes. Individual septin rods will be localized within complexes with nanometer precision using ultra-resolution fluorescence microscopy methods. The septin complex architecture will then be modeled from the resulting pattern of individual rod positions. As a starting point, the best-understood septin complex, the ring-shaped complex at the mother bud neck in yeast involved in cytokinesis, will be investigated. First conclusions from the analysis of this complex will aid in the investigation of a mammalian septin complex at the neck of dendritic spines in neurons. Neither the precise composition nor the global structure of this septin complex are known yet, but morphological and functional analogies of the spine neck with the yeast bud neck suggest that a similar septin-ring structure may be present. The expected results will clarify the role of the septin complexes in yeast cell division and define the rules for septin complex assembly in neurons.",Septin organization by multiparameter photoactivated localization microscopy,FP7,31 May 2012,01 June 2010,173065.0 PANACO,Ghent University * Universiteit Gent,health,"In the ERC-StG-project CoCooN, we investigate the surface modification of nanoparticles by Atomic Layer Deposition (ALD). To enable this research, a rotary ALD reactor was developed. The number of possible applications for nanoparticles has strongly increased in the last decade. For many applications, such as catalysis, batteries, solid-state lighting, but also drug development and biotech, nanoparticles with different surface properties are necessary. Today, and with the help of the ERC- project CoCooN, ALD has proven to be a reliable method for depositing ultrathin and conformal coatings, even on large quantities of (nano)particles. We have designed and built a prototype rotary ALD reactor that enables both thermal and plasma-enhanced ALD surface modification of (nano)particles. In PaNaCo, we will push this rotary ALD reactor to a pre-commercial level.",Particle Nano Coater,FP7,31 July 2015,01 August 2014,149800.0 PANNA,Veneto Nanotech SCPA,construction,The main objective is to develop a novel atmospheric plasma technique for surface cleaning and coating deposition as well as two innovative coatings: a self-diagnostic protective coating and a coating provided with identification marker.,Plasma And Nano for New Age “soft” conservation,FP7,10 July 2016,11 January 2011,0.0 PANOPTES,Durham University,health,"This project will develop methodology for the manufacture of novel peptide-based nanoparticles and nanocapsules to satisfy an unmet clinical need: sustained drug delivery to the posterior segment of the eye. The proposed consortium brings together internationally leading groups in self-assembling polypeptide nanoparticle and nanocapsule preparation by chemical (Durham) and genetic (Nijmegen) approaches, drug loading and in vitro release studies (Helsinki & Madrid), in vitro and in vivo assessment of nanoparticle biocompatibility and functionality (Helsinki, Madrid & Tübingen) and polymer synthesis, processing and industrial validation of manufacturing processes (DSM). Polyester micro- and nanoparticles that have been proposed for ocular drug delivery have several major drawbacks: acidic degradation products cause inflammation; drug release is difficult to control; and peptides and proteins are difficult to encapsulate. A platform of novel, peptide-based nanomaterials, formed through bio-inspired self-assembly processes, will be developed to overcome these problems. Peptide-based materials have a number of attractive features: biodegradation gives non-inflammatory products; self-assembly occurs under mild conditions; they possess a rich chemical diversity; they are defined at the sequence level. Polypeptides and peptide hybrid materials will be processed into nanoparticles, polymeric vesicles (polymersomes) and nanocapsules. These biodegradable and biocompatible materials will be used as containers for the loading, controlled release and cellular delivery of therapeutic molecules. The consortium therefore will enable the industrial manufacture of as-yet unobtainable, high value nanotechnology-based products utilising intrinisically low-energy demand nanobiotechnological phenomena. These will produce a step change improvement in the quality of products for sustained drug delivery to the posterior segment of the eye, enhancing the competitiveness of European industry.",Peptide-based Nanoparticles as Ocular Drug Delivery Vehicles,FP7,31 October 2014,01 November 2010,3900000.0 PARAFLUO,Micro Photon Devices srl,health,"Analytical methods based on fluorescence measurements are widely employed for investigating biological process at cellular level. A modern technique is fluorescence-lifetime imaging microscopy (FLIM), where a map is obtained of the fluorescent emission lifetime versus position in a cell. The objective of project PARAFLUO is an innovative instrumentation system that will enhance and extend the usefulness of FLIM, making possible to obtain simultaneously FLIM data separately for the various spectral components of the emission. There is wide consensus among experimenters that this spectrally resolved technique (called sFLIM) will support a better understanding of the biological processes involved. Such understanding is paramount for the (patho)physiology of tissues and organisms and gives a base for gaining a better insight in key medical issues, such as the origin and growth mechanisms of tumors. The optoelectronic instrumentation developed will be useful also for other market objectives, such as simultaneous multi-spectral profiling of objects by laser detection and ranging (LADAR) techniques. The developments envisaged are essentially: (a) a photon-counting array detector based on the silicon single-photon avalanche diode (SPAD) technology; (b) a new micro-lens system for focusing light onto the detector and (c) an ASIC based multichannel time correlated single photon counting (TCSPC) system, integrated with an optoelectronic setup in a confocal microscope. The base of the PARAFLUO consortium is given by three SME's; each one having a consolidated technical know-how and an active presence in the market over one of the quoted scientific-technical (S/T) areas. Five RTD performers have been selected primarily because of their high international standard in these areas; furthermore, each of them has experience of active collaboration with the SME directly concerned by the specific S/T work. A professional partner supports the coordinator and ensures timely and efficient exchange of materials and information in the project.",Parallel fluorescence spectroscopy tools for micro and nano-analytical applications down to single biomolecules,FP7,31 August 2011,01 June 2009,1133000.0 PARAMCOSYS,Advanced International School of Advanced Studies * Scuola Internazionale Superiore di Studi Avanzati,information and communications technology,"The goal of the project is to increase and deepen the knowledge on the control of dynamic systems at the Department of Mathematics and Statistics, University of Kuopio, based on the idea of flatness, developed recently by M. Fliess and co-workers in France, and on the methodology called parametrization. Here dynamic systems has a control-theoretic meaning of being controlled ordinary or partial differential equation (PDE) systems (of parabolic evolution type). A technically feasible and computational test for checking flatness and parametrizability is still missing. Furthermore, extensions to nonlinear partial differential systems still waits for a developer. Linear partial differential systems can already be controlled via a flatness-based technique, a so-called parametrization method. The scientific objective is to further develop, together with advanced European specialists, control methodology of dynamic systems via flatness and parametrization concepts, and try to extend these results to nonlinear PDE systems. Some methodological results developed earlier in our department will also be developed further and applied. A central application field is control of quantum mechanically described systems. This application field has a key role in developing new measurement principles and corresponding technologies,and interface electronics for future, e.g. mobile, communication systems relying on quantum mechanical principles in quantum computation and quantum control. Due to the plans to develop a new Master of Science curriculum in engineering in the University of Kuopio, and due to the etablation of new research and development units of multinational high-tech companies, e.g. Honeywell and Nokia, in Kuopio and Northern Savo region, knowledge of advanced control engineering and mathematical control theory has to be increased and enlarged to guarantee high level curriculum teaching in the field. Our proposal supports strongly this development.",Parametrization in the Control of Dynamic Systems,FP6,31 July 2008,01 August 2004,326582.0 PARNASS,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"Parallel nanoassembling directed by short-range field forces (PARNASS) is a radical innovative approach for fabricating large volumes of hybrid nanoelectronic devices. This method addresses the challenging physical and engineering problem of very high accuracy over a large area. We think that use of specially designed nanoscale force fields is the only realistic method for large-scale nanomanufacturing. As a primary need we identify research towards a detailed understanding of these forces and development of a technology for parallel short-range forces directed nanoassembling. For that, a deep knowledge of the forces acting between nanoparticles and substrate is necessary. Theoretical and experimental works within this project are directed to get a detailed qualitative and quantitative understanding of the forces. Objectives of the project are: to develop phenomenological understanding of the forces between nanoparticles and the substrate and between nanoparticles themselves; to determine geometry and material of nanostructures which are optimal for nanoparticles trapping and aligning; to define practically allowable nanopositioner design and fabrication technologies; to develop and construct an automated analyser for nanostructured surfaces investigation; to develop and construct a proof-of-concept technology demonstrator including an appropriate hybrid device prototype. We consider a nanoelectronic sensory device with particular carbon nanotubes as an example to demonstrate the proposed nanoassembling technology. Most aspects of this project fall within IST-NMP-3, addressed at the frontier of knowledge aiming at radical innovation in the long term and benefiting of nanotechnology interdisciplinary work. Moreover, it has broader perspective due to its relevance to basic knowledge. Its results will have impact on other thematic priorities like new analytical devices for data acquisition for healthcare, so some project aspects fall within IST-NMP-2.",Parallel nano assembling directed by short-range field forces,FP6,31 August 2008,01 September 2005,1947000.0 PARSEM,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,photonics,"The ultimate goal of this project is to provide a profound knowledge on III-V semiconductor heterostructures-nanostructures. The project will lead to extensive comprehension of growth mechanisms, microstructures and interfacial phenomena, as well as of the interrelation of structural and physical properties in order to control at the atomic level the synthesis, the growth, processing and properties of novel III-V semiconductors such as III-nitride binary, ternary and quaternary alloys. Such materials are extremely promising for the realization of devices for optoelectronic applications in UV to near IR wavelengths (e.g. light emitting diodes, laser diodes, UV detectors), and high temperature, high frequency and power electronics like high electron mobility transistors. In particular, quantum confinement of carriers in quantum wells and dots is anticipated to yield high performance for example by increasing the radiation efficiency of optoelectronic devices. The collaboration in this network of leading European experts in fields ranging from reactor design to electronic properties will revolutionize research in the field. An important objective is a contribution to the advancement and defragmentation of competitive European research in materials science and technology for device applications. The consortium combines the innovative multiscale theoretical analysis of structures and properties with experimental characterisation by a unique collection of state-of-the-art techniques. The most important outcome from this multidisciplinary research effort is that a number of young researchers will be trained under expert supervision. Through mobility among the partners and a series of activities such as workshops and e-learning, they will become capable to employ a unique combination of growth, experimental characterization and theoretical modeling techniques.",Interfacial Phenomena at Atomic Resolution and Multiscale Properties of Novel III-V Semiconductors,FP6,28 February 2009,01 March 2005,2889317.0 PARSIMO,Coventor SARL,information and communications technology,"Integration of heterogeneous systems in a package (SiP) allows smaller, smarter and more energy efficient products for many applications. Through SiPs, even small or medium-sized enterprises could gain access to the development of technologically advanced, miniaturized products. However, to date, the lack of appropriate design methodologies and flows hinders the efficient development of SiPs. PARSIMO aims at enabling first time right design of heterogeneous SiP, which can contain sensors, MEMS, RF or other parts beside the micro- and nano-electronics. In order to handle complex systems, models and modelling methods will be developed which improve the modelling accuracy of sensitive SiP parts while reducing simulation time by orders of magnitude. In addition, partitioning algorithms will be investigated to enable cost, performance and power optimisation at early design stages. Furthermore, procedures for the direct data exchange to packaging tools will be developed, so that a complete design flow can be established as basis for automated, fast and cost-efficient manufacturing of SiP based products. PARSIMO aims at initiating standardization, which will open the application of SiP technology for innovative products of European SME and industry. The developed design methodology will reduce design time by several months and significantly save development costs. Eight industry-driven demonstrators from the automotive, aviation and wireless communication domains emphasize the relevance of SiP technology for future products and the need for the design methodology addressed in PARSIMO.",Partitioning and Modeling of SiP,FP7,06 January 2014,03 January 2011,814245.0 PARTICLE_RISK,Institute of Occupational Medicine,health,"Some NEST have the potential to generate particulates which can enter the body via inhalation, ingestion or dermal absorption. As new materials are generated from sources as diverse as novel combustion systems, nanotechnology or pharmaceutical drug delivery in the life sciences there is potential for human exposure. Inhalation exposure to dusts leads to pulmonary diseases and particle toxicity increases with decreasing particle size. Information is needed regarding the possible risks from exposure to these particles including: the routes of exposure and subsequent disposition; their potential toxicity; appropriate toxicological testing procedures; and susceptible subpopulations. This study will acquire a bank of five particles potentially generated by NEST (NESTP) and will assess the health risk from exposure to these materials through air or the food supply with a work programme, integrating in vitro experiments, animal models of healthy/susceptible individuals and exposure/risk assessment.",Risk Assessment of Exposure to Particles,FP6,31 August 2008,01 June 2005,799575.9 PARTICOAT,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,manufacturing,"The overall objective of the project is to develop a novel, unconventional and cost efficient type of multipurpose high temperature coating systems on the basis of property tailoring by particle size processing of metallic source materials. It shall possess multi-functionality that will comprise thermal barrier effect, oxidation and corrosion protection, lotus effect, electrical insulation at elevated temperatures and fire protection. The concept of the novel approach to protection of surfaces is a coating consisting in its initial state of nano- and/or micro-scaled metal particles with a defined size, deposited by spraying, brushing, dipping or sol-gel. During the heat treatment, the binder is expelled, bonding to the substrate surface achieved, the metallic particles sinter and oxidise completely resulting in hollow oxide spheres that form a quasi-foam structure. Simultaneously, a diffusion layer is formed below the coating serving as a corrosion protection layer and as a bond coat for the top layer. The structure of the coating system shall be adjusted by parameters like selection of source metal/alloy, particle size, substrate, binder and a defined heat treatment. For fire protection the formation of hollow oxide spheres will be processed in a separate step before deposition. The flexibility of the new coatings integrates a wide field of application areas, such as gas and steam turbines in electric power generation and aero-engines, combustion chambers, boilers, steam generators and super-heaters, waste incineration, fire protection of composite materials in construction as well as reactors in chemical and petrochemical industry. A broad impact will thus be ensured increasing safety and the durability of components by an economic, multifunctional and flexible protection of their surfaces. The novelty will provide a real step change in the understanding of materials degradation mechanisms in extreme environments.",New multipurpose coating systems based on novel particle technology for extreme environments at high temperatures,FP7,10 July 2014,11 January 2008,4800000.0 PARYLENS,University of Applied Sciences Western Switzerland * Haute École Spécialisée de Suisse Occidentale,health,"The main goal of the project PARYLENS is to develop the next generation optical devices, based on an innovative and reliable concept inspired by natural optical systems such as the human and the fly eyes. We propose the following devices to the European citizen and industry: 1) tuneable lenses 2) truly accommodative intraocular lenses 3) bistable flexible displays The development of those devices relies on recent advances in nanotechnology combined with the patented SOLID (Solid On Liquid deposition) process, which offers the possibility to grow a stable solid layer directly onto a liquid, such that the solid uniformly replicates and encapsulates the liquid template. When using the polymer Parylene as solid layer, the resulting interface is perfectly smooth and the liquid template remains unaffected, which is ideal for optical applications. Parylene is stable, biocompatible, highly transparent, and can be deposited in a one-step process also on liquids. PARYLENS proposes to develop low cost yet high quality, reliable smart devices. The actuation of the tuneable lenses will rely on Parylene-based electroactive polymers and liquid crystals. Tuneable lenses are expected to have an impact on the consumer electronics market (mobile phones, cameras, etc) in addition, the development of low actuation voltages tuneable lenses will profit to the biomedical devices market (artificial eyes, endoscopes, etc). The truly accommodative intraocular lenses will closely mimic the structure and shape of the crystalline lens of the human eye. They will also prevent inflammation and infections. The structure of microlens arrays will be used to develop flexible bistable liquid crystals displays. The consortium is well balanced (12 partners from 8 countries) and goes for full complementarity. It comprises 4 SMEs, 3 universities and 4 research centres. Together they will make this ambitious multidisciplinary project a reality.",PARYLENE based artificial smart LENSes fabricated using a novel solid-on-liquid deposition process,FP7,30 September 2013,01 October 2010,3838646.0 PAS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"The proposed international partnership with the US, Japan, Canada and Russia as third countries and France, Turkey and Israel as beneficiary counties is focused on multi-phase flows that have technological applications. The science focus will be pattern generation, mixing, instabilities, and the control of such flows. The partnership has unique research aspects. The substantial resources of the partner countries in the target research areas will create a super-class status for the current research programs in the field. More importantly, early researchers from the beneficiary countries will receive an outstanding experience and become more marketable in the 21st century workplace. Intellectual Impacts: The partnership will advance multiphase fluid and thermal sciences with several technological applications including bio-sensors, drug delivery devices, flow instability and space enabling technologies for a multitude of industries related to pharmaceuticals, metallurgy and energy. Key science issues associated with patterns and instabilities in multiphase flows will be resolved. The proposed collaboration will by virtue of its impact encourage ultimate partnerships between industry and academe and benefit the economy of the Europe and Associated Countries. Broader Impacts: The project will enhance the training of several young researchers in cutting edge international research settings. Dissemination will be achieved by journal publications, webminars and web sites. Transfer of Knowledge: The combined expertise of partner and MS/AC countries will result in transfer of knowledge via site visits and workshops. It will include numerical and analytical methods ranging from spectral and finite volume methods to weak nonlinear techniques as well as experimental techniques associated with nanotechnology to microgravity. The transfer of knowledge will take place in both directions and will become the permanent foundation for sustained collaboration.",Patterns and Surfaces,FP7,30 September 2015,01 October 2011,493900.0 PATCHYCOLLOIDS,Sapienza University of Rome * Università degli Studi di Roma La Sapienza,health,"An unprecedented development in particle synthesis is providing methods to generate high yield quantities of nano- and micro-particles of different shapes, compositions, patterns and functionalities and an unprecedented diverse spectrum of particle patchiness, significantly extending the naturally available choices. These methods draw from the diverse fields of chemistry, physics, biology, engineering and materials science, and, in combination, provide a powerful arsenal for the fabrication of new particulate building blocks, the molecules of tomorrow materials, self-assembling into molecular-mimetic and unique structures, fluids, and gels made possible solely by their design. The new particles offer the possibility to go beyond the spherical interaction case, to move from the colloidal atom to the colloidal molecule --- providing valence to colloids --- and to further strength the analogies between colloids and globular proteins. The present theoretical and computational project aims at providing new ideas for developing effective methodologies of bottom-up manufacturing, at providing the scientific community with the background necessary to fully control the self-assembly of these new building blocks as well as solutions to relevant condensed-matter physics problems. The project also aims at developing realistic models of DNA-functionalized nano and micro particles, presently the most promising and versatile building block of bio-colloid materials. Understanding the assembly of patchy particles will offer fine control over the three-dimensional organization of materials, as well as the combination of different materials over several length scales, making it possible to design a spectrum of crystal polymorphs and self-assembled ordered and disordered structures unprecedented in colloid science.",Patchy colloidal particles: a powerful arsenal for the fabrication of tomorrow new super-molecules . A theoretical and numerical study of their assembly processes.,FP7,31 March 2014,01 April 2009,1559159.0 PATHCHOOSER,University College Dublin,health,"Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do so (via diffusive or other non-specific processes) is limited in size and physiochemical properties, greatly restricting the therapeutic strategies that may be applied. In practice, after several decades of limited success, there is a broad consensus that new multi-disciplinary, multi-sectoral strategies are required. Key needs include detailed design and understanding of the bionano-interafce, re-assessment of in vitro models used to assess transport across barriers, and building regulatory considerations into the design phase of nanocarriers. The overarching premises of the PathChooser ITN are that (i) significant advances can only be made by a more detailed mechanistic understanding of key fundamental endocytotic, transcytotic, and other cellular processes, especially biological barrier crossing; (ii) elucidating the Mode of Action / mechanism of successful delivery systems (beyond current level) will ensure more rapid regulatory and general acceptance of such medicines. Paramount in this is the design and characterization of the in situ interface between the carrier system and the uptake and signalling machinery. (iii) inter-disciplinary knowledge from a range of scientific disciplines is required to launch a genuine attack on the therapeutic challenge. The PathChooser ITN program of research and training will equip the next generation of translational scientists with the tools to develop therapies for a range of currently intractable (e.g. hidden in the brain) and economically unviable diseases (e.g. orphan diseases affecting a limited population).","Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers",FP7,30 September 2017,01 October 2013,3036614.0 PATHFINDER,Stichting Katholieke Universiteit * Catholic University Foundation,health,"Tumour cells survive and grow because they are not effectively recognized by the immune system as ¿foreign¿ and are therefore not attacked and destroyed like most pathogens. We have already demonstrated the clinical value of dendritic cell (DC) vaccines that activate the immune system to fight cancer. Treating more than 300 patients with metastatic melanoma, we achieved extended survival in 40% of patients by maturing dendritic cells from the patient¿s blood in-vitro, loading them with cancer-specific antigens and re-injecting them into the patient. These DCs then activate tumour-specific T cells in the lymph nodes. Our success in this area of research makes us a world leader in dendritic cell immunotherapy. However, despite these encouraging results, more work needs to be done if this type of therapy is to move into routine cancer care. Therefore the primary objective of the research detailed in this proposal is to significantly enhance cancer treatment efficacy by developing multifunctional nano-sized vaccine carriers that specifically target DCs and T cells in-vivo. If successful, this will also eliminate the costly in-vitro steps associated with current dendritic cell therapy. The recent discovery of pathogen recognition receptors on dendritic cells opens up the possibility of exploiting these receptors to target dendritic cells within the body. We will therefore develop highly functionalized, slow-release vaccine carriers that target DCs in this way. In order to directly activate tumour-specific T cells, we will develop highly flexible polyisocyanide polymers that mimic naturally occurring DCs. To functionalize these polymers, we aim to develop a revolutionary DNA-based bar-coding technique. I expect this new approach leads to major advances in tumour immunotherapy.",Mimicking pathogens; an integrated nano-medicine approach to developing intelligent cancer vaccines.,FP7,31 October 2016,01 November 2011,2498680.0 PC-NANOSCOPY,University of Buenos Aires * Universidad de Buenos Aires,manufacturing,"New techniques in far-field fluorescence microscopy have improved optical resolution down to several times the diffraction limit. The resolution currently achieved with these techniques is 28 nm. Recently it was proposed that fluorescent reversible molecular compounds ('photoswitches') could be utilized in fluorescence microscopy, allowing, in principle, to improve the resolution up to molecular dimensions, i.e. 1-5 nm. The use of these photochromic compounds should enable the utilization of very low light intensities, thus making the technique particularly suitable for biological applications.It is proposed to investigate the feasibility and performance of photochromic fluorescent compounds in modern far-field fluorescent microscopy techniques, as well as explore its different potential uses and applications. The aim of this project is to improve resolution to a few nanometers and, in particular, apply the technique to live-cell imaging as well as to memory storage and lithography.Undertaking this scientific project in a field’s leader's laboratory will give me the opportunity to learn advanced microscopy techniques, and acquire a significant experience and expertise in the field. After having completed my training in Germany, I will be prepared to set up a research team and start an independent research career in my home country, Argentina.",Application of photochromic compounds to improve resolution in fluorescence microscopy up to molecular scale,FP6,31 March 2009,01 April 2008,58800.1 PC-NANOSCOPY,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),manufacturing,"New techniques in far-field fluorescence microscopy have improved optical resolution down to several times the diffraction limit. The resolution currently achieved with these techniques is 28 nm. Recently it was proposed that fluorescent reversible molecular compounds ('photoswitches') could be utilized in fluorescence microscopy, allowing, in principle, to improve the resolution up to molecular dimensions, i.e. 1-5 nm. The use of these photochromic compounds should enable the utilization of very low light intensities, thus making the technique particularly suitable for biological applications.It is proposed to investigate the feasibility and performance of photochromic fluorescent compounds in modern far-field fluorescent microscopy techniques, as well as explore its different potential uses and applications. The aim of this project is to improve resolution to a few nanometers and, in particular, apply the technique to live-cell imaging as well as to memory storage and lithography.Undertaking this scientific project in a field’s leader's laboratory will give me the opportunity to learn advanced microscopy techniques, and acquire a significant experience and expertise in the field. After having completed my training in Germany, I will be prepared to set up a research team and start an independent research career in my home country, Argentina.",Application of photochromic compounds to improve resolution in fluorescence microscopy up to molecular scale,FP6,31 March 2010,01 April 2008,150856.0 PCUBE,University of Zurich * Universität Zürich,health,"The most important prerequisite and challenge in structural biology research at the atomic level by any method is the availability of sufficiently large amounts of highly purified functional proteins due to the increasing size and complexity of target proteins or protein complexes to be analyzed. Heterologous expression in bacteria, yeast, insect, or mammalian cells combined with many attempts involving different DNA constructs that result in a large variety of protein variants is instrumental to obtain sufficiently high yields. This means high-throughput methods employing robotics and specialized infrastructure are essential to efficiently reach the state of obtaining functional protein and/or crystals for X-ray structure determination. PCUBE ('protein production platform') combines existing infrastructures and know-how of leading European laboratories in bacterial, eukaryotic expression of proteins, in high-throughput crystallization and in libraries design for the effective production and crystallization of macromolecules. The program aims at offering these various state-of-the-art platforms to research groups from EC member and associated states for the efficient production of proteins for their structural studies. Each infrastructure will offer defined procedures for applying for transnational access. Scientific selection committees will give priorities to applications by scientific criteria of excellence only. Researchers from the different sites offering infrastructure are combining efforts to improve the methods in the various areas by collaborating by joint research activities. These include the improvement of the automation for synthesising DNA constructs, for parallel expression, for improved libraries, for the efficient selection of affinity molecules from libraries to particular target proteins as well as developing new methods for crystallization at the nanoliter scale.",Infrastructure for Protein Production Platforms,FP7,31 March 2013,01 April 2009,6599997.0 PE-NANOCOMPLEXES,Eotvos Lorand University * Eötvös Loránd Tudományegyetem,health,"The major goal of the proposed project is to facilitate the applicant's reintegration to his home institute after a successful Marie Curie training period at the Surface Chemistry, Dept. of Chemistry, KTH, Stockholm. To reach this goal the host (Eötvös Lorand University, Budapest) offers a permanent position for him and provides the infrastructure necessary to implement the proposed research project. The proposed research project consists of two independent work packages. The first work package aims at developing and applying a nanoprobe technique to determine the optimal structure of DNA-polyelectrolyte complexes, which is an important step required to increase the efficiency of current non-viral gene delivery systems. The second work package will map the effect of multivalent ions on the interaction of a flexible polyelectrolyte and an oppositely charged surfactant, which will provide information how the strong ion-ion correlations, introduced by the multivalent ions, affect surfactant/polyelectrolyte self-assembly. Finally, the reintegration grant will allow the researcher to transfer his new competences (related to modern surface characterization techniques, e.g. DPI, AFM, QCM-D, ellipsometry) to the host institution of the reintegration period and to the wider audience of its students.",Polyelectrolyte nanocomplexes,FP7,14 February 2012,15 February 2009,45000.0 PEACH,Starlab Barcelona SL,information and communications technology,"An important objective of FET is the development of Presence technologies. Presence is an emerging field focusing on understanding the cognitive experience of being somewhere and developing technologies to generate and augment it (being someone or something, somewhere, sometime, without physically being there). By nature a deeply interdisciplinary field, Presence spans a wide range of subjects: from neuroscience and cognition to artificial intelligence, sensors and systems. This horizontal character makes Presence a fascinating and fertile interdisciplinary field, but it is can also stunt its growth, as researchers are scattered across disciplines and groups worldwide. A coordination activity promoting discipline connect, identity building and integration while defining future research and policy directions is needed. The first goal of the three-year long PEACH Coordination Action is to stimulate, structure and support the research community, with special attention to the challenges associated to the interdisciplinary character of the field, and to produce visions and roadmaps to support the construction of the Presence ERA. Secondly, because Presence research is set to produce disruptive technologies which can cause profound social impact and raise serious ethical issues, PEACH will analyse the relation of Presence technologies with society (trends, ethics, legal aspects), foster the contact of researchers with the market and enhance the Public Understanding of Presence research and technology. PEACH will achieve its objectives by providing an open central information point for all the stakeholders, using a working methodology based on Working Groups and Action Events (Consultation Meetings, Summer Schools, a Science Fair and an Industry Event), and with the support of Presence II FET IPs. Many key researchers from several continents have already expressed their support to PEACH and desire to participate as Collaborative Members.",Presence Research in Action,FP6,30 April 2009,30 April 2006,1000000.0 PEASSS,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,transport,"The main objective of the PEASSS project is to develop, manufacture, test and qualify “smart structures” which combine composite panels, piezoelectric materials, and next generation sensors, for autonomously improved pointing accuracy and power generation in space. The smart panels will enable fine angle control, and thermal and vibration compensation, improving all types of future Earth observations, such as environmental and planetary mapping, border and regional imaging. This new technology will help keep Europe on the cutting edge of space research, potentially improving the cost and development time for more accurate future sensor platforms including synthetic aperture optics, moving target detection and identification, and compact radars.",Piezoelectric Assisted Smart Satellite Structure,FP7,12 July 2017,01 January 2013,0.0 PECDEMO,Helmholtz Center Berlin for Materials and Energy * Helmholtz-Zentrum Berlin für Materialien und Energie (HZB),energy,"To address the challenges of solar energy capture and storage in the form of a chemical fuel, we will develop a hybrid photoelectrochemical-photovoltaic (PEC-PV) tandem device for light-driven water splitting. This concept is based on a visible light-absorbing metal oxide photoelectrode, which is immersed in water and placed in front of a smaller-bandgap thin film PV cell. This tandem approach ensures optimal use of the solar spectrum, while the chemically stable metal oxide protects the underlying PV cell from photocorrosion. Recent breakthroughs have brought metal oxide photoelectrodes close to the efficiency levels required for practical applications. We will use our extensive combined expertise on nanostructuring, photon management, and interface engineering to design innovative ways to solve the remaining bottlenecks, and achieve a solar-to-H2 (STH) energy conversion efficiency of 10% for a small area device, with less than 10% performance decrease over 1000 h. In parallel, our academic and industrial partners will collaborate to develop large-area deposition technologies for scale-up to ≥50 cm2. This will be combined with the large-area PV technology already available within the consortium, and used in innovative cell designs that address critical scale-up issues, such as mass transport limitations and resistive losses. The finished design will be used to construct a water splitting module consisting of 4 identical devices that demonstrates the scalability of the technology. This prototype will be tested in the field, and show a STH efficiency of 8% with the same stability as the small area device. In parallel, our partners from industry and research institutions will work together on an extensive techno-economic and life-cycle analysis based on actual performance characteristics. This will give a reliable evaluation of the application potential of photoelectrochemical hydrogen production, and further strengthen Europe's leading position in this growing field.",Photoelectrochemical Demonstrator Device for Solar Hydrogen Generation,FP7,31 March 2017,01 April 2014,1830644.0 PECQDPV,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),energy,"Colloidal quantum dots (CQDs) have recently attracted significant attention as a candidate material for optoelectronic devices, and in particular photodetectors and solar cells. These materials can be manufactured in the solution phase and spin-cast onto a variety of substrates, significantly reducing the cost of device fabrication. Additionally, the bandgap of CQD films can be tuned to allow absorption of specific wavelength regions by varying the diameter of the CQDs, due to the quantum confinement size effect. To maintain efficient charge extraction in these devices, the thickness of the CQD layer is restricted, resulting in devices that are limited by non-complete absorption. To improve efficiencies it is necessary to decouple the optical thickness from the electrical thickness by employing novel light-trapping schemes. Plasmonics offers the opportunity to confine light in sub-wavelength volumes, increasing the absorption in thin films. Discrete metal particles can be fabricated on a glass substrate, by simple self assembly or by nano-fabrication techniques, before the CQD are spin cast thus allowing plasmonic scattering structures to be incorporated into the cells without significantly increasing the complexity or cost of cell fabrication. By integrating plasmonic light trapping based on sub wavelength scattering structures with CQD devices, we will aim to dramatically increase the absorption, while maintaining good electrical characteristics, and hence achieve gains in overall performance and efficiency. Additionally, we will study the physical mechanisms behind plasmonic enhancement by employing FDTD simulations to investigate the scattering behaviour of single particles and periodic arrays embedded in CQD films, and combine this with simple conceptual models to design optimal scattering structures. These will be fabricated on CQD devices with the aim of providing the maximal absorption enhancement possible with plasmonic structures.",PLASMONICALLY ENHANCED COLLOIDAL QUANTUM DOT PHOTODETECTORS AND PHOTOVOLTAICS,FP7,30 April 2014,01 May 2012,176053.0 PECTICOAT,Joint Research Centre (JRC) of the European Commission,health,"Surfaces of medical materials and devices that come into direct contact with human tissues need to be fine-tuned with regard to both physical and biological properties. A cross-disciplinary nanotechnology approach is proposed that aims to impart material surfaces with appropriate biological properties. This approach gathers competences from across Europe and includes a critical mass of resources necessary to accelerate the R&D process. The biomolecules that are to be grafted onto surfaces to function as nanocoatings have been selected from a class of complex polysaccharides, the pectic rhamnogalacturonans, that are known to possess anti-inflammatory properties as well as desirable physical properties. Sugar molecular structure will be altered in a controlled manner so as to favourably influence living cell behaviour around the coated materials. Current knowledge and expertise within our project team covers technologies to manufacture a range of tailored polysaccharides, to attach the molecules covalently to relevant biomaterials (e.g. titanium for dental implants) and to characterize the grafted surfaces and to assess their biocompatibility both in vitro and in vivo. We expect to generate evidence demonstrating both the antiinflammatory and molecular flexibility of the innovative nanocoatings. This will open a platform for the development of a large range of applications that will be defined through industrial guidance and result in solutions for current bioincompatibility problems of various implantable devices. Industrial monitoring and engineering will allow the exploration of a wide range of applications (breast implants, meshes etc.). For one of these: the dental application, the involvement of industrial SMEs covers the full production chain from raw material to prototype design which will lead in to a demonstration phase.",Nanobiotechnology for the coating of medical devices,FP6,31 March 2008,01 April 2005,1850000.0 PEGASUS,AIMPLAS - Plastics Technology Centre * Asociación de Investigación de Materiales Plásticos y Conexas,transport,"The main goal of PEGASUS is to develop a new and highly innovative methodology for SMEs working in the automotive industry, specifically aimed at integrating engineering and new processing concepts. It will combine state-of-the-art thermoplastics (TPs); TP composites in the polymer processing industry in a single modular system. PEGASUS will: -Develop a new Integrated Design and Engineering Environment (IDEE) based on KBE (Knowledge Based Engineering) for SMEs supplying the automotive sector. Based on existing developments in the Aerospace industry it will support the 5-day car concept and facilitate the integration of functions, processes and materials in a single industrial process. -Integrate knowledge from within the new supply chain concept allowing SMEs to co-operate and provide a quick, high-tech and customisable service directly to OEMs at a lower cost. -Provide an innovative; flexible process configuration unit on demand that combines the latest moulding technologies adapted through the IDEE to each components requirements. -Make use of nano-particles in colouring technology to avoid additional painting reducing VOCs. ·Develop disassembly on command components by expandable (nano) adhesive particles reducing disassembly times by 25%; local reinforcements using long fibre thermoplastcs; improved Pedestrian Protection reducing severe injuries by up to 10%. An IP-SME draws all of the partners from 8 EU states together in an ideal funding instrument, which would otherwise be difficult or impossible. These partners will ensure that the exploitation will be maximised across the EU. The project will demonstrate, by producing a new rear part of a Smart car, the possibilities open to a new SME intensive supply chain concept in the car manufacturing industry. It will result in an estimated 30% increase in the size of the market open to SMEs. Growth in the sector as a result of PEGASUS could be approximately 40.000 new jobs for SMEs",PEGASUS: Integrating engineering processing and materials technologies for the European automotive sector.,FP6,31 December 2010,01 September 2006,6000000.0 PELO,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),health,"Photoepilation (also known as laser hair removal) is a non-surgical cosmetic procedure that uses intense pulsed light to remove unwanted hairs and slow down their regrowth. Current approaches rely on the natural color contrast between the hair and the skin to damage the hair by photo heating. They consequently fail for fair hairs (blond and white) and, even in the ideal configuration of dark hairs on clear skin; the required light intensities are responsible for local skin injuries that can become permanent. In this project, we propose to exploit the latest advances in nanotechnology to develop a novel photo-epilation technique with reduced invasiveness, higher efficiency and wider applicability over state of the art. Our approach will first decrease local injuries of the surrounding skin by substantially reducing the required light intensity. Beyond, we expect that it could enable slowing down the hair regeneration and extending for the first time laser hair removal to blond and white hairs.",Plasmon-enhanced photoepilation,FP7,31 July 2013,01 May 2012,140375.0 PELORUSYN,University of Cambridge,health,"Novel microtubule-stabilising agents have great potential as cancer chemotherapeutic agents - where there is a need for improved pharmacological profiles, reduced side-effects, and efficacy against otherwise drug-resistant cancers. The 16-membered macrolide peloruside A is a potent inhibitor of cancer cell proliferation at the nanomolar level. By sharing the same microtubule-stabilising mechanism as Taxol and retaining activity against multidrug-resistant cancer cells, peloruside A represents a potential new chemotherapeutic agent to the treatment of solid tumours. Due to the supply shortage from the sponge source, chemical total synthesis is essential for generating useful quantities of peloruside A to enable its preclinical development. The primary objective of the proposed project is to develop a flexible and stereocontrolled synthesis of peloruside A, using methodology developed in the host group, in order to provide material for further biological evaluation. A secondary objective is the synthesis of simplified structural analogues, including hybrids with the epothilones, which would then be tested for tubulin binding and cytotoxicity to determine the essential structural characteristics for bioactivity.The applicant will improve her research training and expand her knowledge and experience in the synthesis of biologically active molecules that may have therapeutic potential. Not only will there be opportunities to learn and develop new synthetic methodologies, but also to participate in multidisciplinary research at the interface of chemistry, biology and medicine. The Chemistry Department of Cambridge University is a world renowned institution and the host scientist has exceptional experience in total synthesis and the development of new synthetic methods. The training/mobility period will provide a good synergy with the applicant and apos;s predoctoraltraining and offers an excellent research infrastructure.",Synthesis of Peloruside A and Analogues as Novel Microtubule-Stabilising Anti-Cancer Agents,FP6,31 May 2006,01 January 2005,159046.4 PEPINEN,University of Oxford,information and communications technology,"Since their discovery carbon nanotubes have generated huge interest due to their one-dimensional nature and their unique physical properties. However, a number of serious obstacles stand in the way of using them as useful functional nanomaterials. They are in fact poorly dispersable in common solvents and generally produced in a wide range of electronic types, with separation by type proving difficult. In view of these issues attention is now moving towards inorganic alternatives. In this context nanowires made up of molybdenum, sulfur and iodine (MoSI) and WS2 nanotubes have been shown to be within the most promising. Easy fabrication readily scaled up for a range of compounds, uniformity in diameters and electronic type and functional properties very similar to carbon nanotubes are among their most important qualities. However, being new class of materials, they are yet to be extensively studied. A complete understanding indeed is crucially required for further exploitation in the numerous technological applications they have been proposed for. The project aims to address crucial problems such as dispersability, processability and manipulation of these objects. Finding the optimal dispersion conditions will powerfully bring these materials on the technological and applicative scene. Once unlocked the solution processing issues other innovative and intriguing aspects will be covered, using the most advanced electron microscopy technologies to intimately understand the role of punctual structural defects in the ultimate physical properties of the materials. Correlation between physical properties and structural modifications will be for the first time established. The success of this proposal will give an important and unique contribute to the field, leading to technological innovations, community relevance and to a significant launch of the researcher, Dr. V. Nicolosi, in her first appointment in an advanced career at interdisciplinary level.",Processing and Electron Probing Inorganic Nanostructures for Emerging Nanotechnologies,FP7,03 April 2010,03 May 2009,168256.91 PEPTIDE NANOSENSORS,University of Rome Tor Vergata * Università degli Studi di Roma Tor Vergata,health,"The overriding goal of the proposed research program is the development of novel reagentless, electrochemical peptide based sensors for the detection of multiple diagnostic proteins. The approach, which will utilize electrochemistry to monitor the binding-induced folding of peptide/polypeptide used as recognition elements, will be rapid, specific, convenient, and critically, selective enough to be employed directly in blood serum and –we propose- whole blood. This goal will be achieved bringing together an international and interdisciplinary group of research teams and building a collaborative environment for research, innovation and technology transfer in the field of electrochemical nanosensors. This program will allow the exchange of knowledge and expertises through training visiting periods of early stage and experienced researchers. The training will involve each single aspect of sensor development. For this reason, the research teams selected encompass all of the requisite expertises and each of them has a particular focus on a single step of sensor production and testing. The outcome of the fellowship will be crucial for the early stage researchers involved. This in fact will strengthen their scientific knowledge through a focused training at the host institutions and will facilitate the acquisition of experience in new, interdisciplinary fields at the interface of analytical chemistry, electrochemistry, molecular biology and clinical chemistry. The program will also allow the exchange of experienced researchers. This will give the possibility to build a strong net of collaboration, which will be very important for future careers of the involved scientists. The laboratories involved have similar objectives but with completely different scientific approaches and expertise, this program will help the integration and collaboration among the research teams and the establishment of a long-term collaboration between Europe and key Third Countries.",Development of Electrochemical Peptide Nanosensors for protein and antibody detection,FP7,30 April 2015,01 May 2012,191400.0 PEPTIDEPADLOCK,London School of Economics and Political Science,health,"Our ability to tailor individual proteins is now sophisticated, but our ability to assemble such proteins into larger structures is still primitive. Proteins are typically joined by reversible or non-specific linkages. We have designed a unique way to connect protein building blocks irreversibly and precisely, via spontaneous isopeptide bond formation. This involves modifying proteins with a short peptide tag (SpyTag) that is based upon remarkable chemistry used by pathogenic Gram-positive bacteria. Here we will develop this novel approach to address major challenges in synthetic biology. We will engineer SpyTag capture towards infinite affinity (defined as diffusion-limited on-rate and no off-rate), to transform the sensitivity of peptide detection in living systems. We will also apply SpyTag to create a new generation of protein polymers, irreversibly assembled with molecular precision and tailored branching. In parallel we will harness SpyTag to enhance circulating tumor cell (CTC) capture, one of the most promising ways to achieve early cancer diagnosis. In capturing CTCs and other rare cells from blood, the high forces mean that even the strongest non-covalent linkages fail. SpyTag covalent bridging, in concert with super-resolution live cell fluorescence microscopy, will give us the opportunity to answer key questions about the forces and membrane dynamics at the magnetic bead:cell synapse. We will exploit these insights and SpyTag-assembled antibody polymers to dramatically reduce the threshold of antigen expression for CTC capture. This comprehensive program of research will explore novel concepts in protein recognition and cellular response to force, while creating conceptually new tools, making it possible for biologists in a wide range of areas to step beyond existing barriers.",Peptide padlocks evolved towards infinite affinity for antibody nanoassembly and ultrasensitive cell capture,FP7,30 April 2019,01 May 2014,1616328.0 PEQUPHOT,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Plasmonics has received a lot of attention because of the unique optical properties of metal nanostructures that allow, for example, strong focusing of light and strong field enhancements. While plasmonics is widely proposed for improving performances of optoelectronic devices, its applicability still has to be proven. Photodetectors are well-established for different applications ranging from digital photography to biomedical imaging. However, because of their versatile use there is a great demand for low-cost devices. One way to achieve low-cost photodetectors is by employing solution-processed quantum dots as active material. Quantum dots are a promising medium because of the tunability of the absorption spectrum by varying their size due to the quantum confinement effect and because of the low-cost fabrication technique due to their solution processability. However, the performance of quantum dot photodetectors has been limited so far to either being ultra-sensitive, but rather slow, or high-speed with a low sensitivity. We will break this compromise by concentrating light into nanoscale semiconducting volumes by employing plasmonic structures. Therefore, we will numerically simulate the interaction between the incident light, the plasmonic structure, and the absorbing quantum dots, by using commercial simulation software. In a next step, we will fabricate the plasmonic structures and we will determine an optical absorption enhancement by measuring the photoluminescence of the quantum dots in the vicinity of the plasmonic structure. In a final step, we will fabricate the actual photodetector and characterize its performance by optoelectronical measurements.",Plasmonically-enhanced Quantum Dot Photodetectors,FP7,31 March 2014,01 April 2012,176053.0 PERCERAMICS,Riga Technical University * Rīgas Tehniskā Universitāte,health,"The project will develop a percolated nanostructured electrically polarized ceramics (CER) fabricated from hydroxylapatite (HAP) to improve quality of bone eligible bioimplants, work out new material for immobilization of microorganisms for their further use to product of various biologically active compounds (BAC) and purify the environment. A surface of CER will provide a relevant biological - non-biological interface to adhere cells/microorganisms. A surface morphology of CER will be supplied at a nano scale eligible for a cell receptor 'tail' size and will be 'packed' from HAP nanoparticles. The CER surface will be charged and supplied with a web of the canals. Engineering support employing knowledge acquired from computational physics research on charging and adhesion/cohesion by HAP nanoparticles will be provided. To meet CER applications the project is focused to: investigation of yeast cell physiology in biofilms immobilised in novel matrices; immobilization of bacterial cells and yeasts for the purification of the environment, bioremediation and industrial biotechnological processes; working out of active dry preparations of immobilized microorganisms; fabrication of bone eligible implants. The results are planned to implement in industry, medicine, environment and biotechnologies. New benefits in safety of environment, health and biotechnologies will be challenged. Professionals from computational and material physics, chemistry, engineering of materials and their characterization, microbiology, biotechnology, wastewater treatment, orthopaedics and industries will be involved on a multidisciplinary approach and a critical mass of the project. A sustainable development at relevant industries and research will spurt. The project partners' cooperation will become stronger and reach European networking scale to strengthen and integrate the European Research Area.'",Multifunctional percolated nanostructured ceramics fabricated from hydroxylapatite,FP6,31 January 2007,01 February 2004,1800000.0 PERCIGS,Uppsala University * Uppsala Universitet,energy,"To a large extent, the latest CIGS improvement is due to enhancements in the semiconductor material quality. However, as the material quality of the semiconductors improves, other parts of the solar cell are becoming the new bottlenecks to increase the efficiency further towards the theoretical limit for non-concentrated light, which is 30 %. Therefore, this project is focused on an advanced, yet industrially feasible, device structure: The introduction of point contacts and a passivation layer will be used to reduce the back contact recombination and thus enhance efficiency. The application focuses towards CIGS based solar cells, but the concept can be generalized to other high quality thin film solar cell technologies as well. The project is structured in four sub-projects, of which the motivations are described below. Specific goals: • An innovative concept to reduce the high recombination back contact surface area will be developed. This will drastically reduce the recombination rate at the back contact for state of the art CIGS solar cells • Increase of solar cell efficiency by up to 1.5 absolute percent by increasing photo-generated voltage and current. • The concept will also be used as a powerful tool to investigate the influence of grain boundaries in the polycrystalline CIGS semiconductor material. The project has four main objectives: (1) point contact development, (2) assessment of passivation layers, (3) application in solar cell devices, and (4) a CIGS material study. A successful outcome will advance the current state-of-the-art in CIGS research, through: • New methods to develop nano-sized contacting points • Novel (rear) passivation layers for CIGS material • An advanced device structure to increase CIGS solar cell efficiency • Improved understanding of the influence of grain boundaries on charge transport in CIGS material",PercIGS,FP7,14 August 2014,15 August 2012,181418.0 PERSONA,Vodafone Omnitel NV,environment,"PERSONA aims at advancing the paradigm of Ambient Intelligence through the harmonisation of Ambient Assisted Living (AAL) technologies and concepts for the development of sustainable and affordable solutions for the social inclusion and independent living of Senior Citizen, integrated in a common semantic framework. It will develop a scalable open standard technological platform to build a broad range of AAL Services, to demonstrate and test the concept in real life implementations, assessing their social impact and establishing the initial business strategy for future deployment of the proposed technologies and services. The main challenges of PERSONA are: - To find solutions and develop AAL Services for social inclusion, for support in daily life activities, for early risk detection , for personal protection from health and environmental risks, for support in mobility and displacements - To develop a technological platform that allows the seamless and natural access to those services indicated above,. - To create a psychologically pleasant and easy- to- use integrated solutions - To demonstrate that the solutions found are affordable and sustainable for all the actors and stakeholders involved: elderly citizens living, welfare systems, service providers in the AAL market. The PERSONA technical platform will exploit and incorporate a broad range of relevant technologies which are developed and integrated in the project: AAL system reference architecture, micro- and nano-electronics, embedded systems, Human Machine Interfaces , Communication , software, web and network technologies, biosensors, embedded and distributed sensors, energy generation and control technologies, and intelligent software to tools for decision support. An important measure of success for the project will come from the outcome of the evaluation and validation in extensive test-beds and trials in three sites in Spain, Italy, and Denmark .",PERceptive Spaces prOmoting iNdependent Aging,FP6,30 June 2010,30 December 2006,6749979.0 PHAGE-BEADS,University of Cambridge,health,"Virus particles are increasingly used as building blocks for composite materials. Surface modification of these biological nanoparticles can be accomplished by genetic engineering and offers the possibility to combine directed evolution of molecular function with the assembly of more complex materials and devices. Virus display systems, especially phage display, have been extensively used for evolving peptides and proteins capable of specific binding to a diverse range of biomacromolecules and inorganic materials. Recently life science approaches emerged using virus particles as substitute antibodies in diagnostic tools. To harvest the full potential in connecting virus display technology with materials, smart fluid handling approaches must be applied allowing to process high numbers of samples. This project is about combining droplet microfluidics, a technology dealing with monodisperse water in oil emulsion droplets, with phage display. The emulsion droplets represent isolated vessels with volumes in the pico- to nanoliter range and can be split, merged, incubated and sorted at high frequency. In addition, hydrogel matrixes will be applied. They serve as scaffold for phage immobilization and allow to transfer the sample from emulsion to an aqueous phase while retaining compartimentalization. The resulting gel beads will be designed as such that proteins can diffuse freely while the phages are immobilized in the matrix. The concept will be applied for directed evolution of enzymes and the development of novel diagnostic tools.",Hydrogel-Phage Composite Materials and Droplet Microfluidics,FP7,30 April 2012,01 May 2010,180603.0 PHANTASY,University College Cork,photonics,"The proposal covers the planned actions of a consortium consisting of five members. These are all research organisations, three of which are EU -based with one other being based in Russia and the final organisation being based in Japan. The consortium intends to establish a research programme which is aimed at the production of advanced structures that include colloidal assemblies, nanoparticles, oxides and metals in order to gain a fundamental understanding of their properties with the aim of using them for manipulation of light on the nanoscale. The planned work is described in detail in the form of three work packages (WP). The first addresses key roadblocks in the exploitation of nanophotonic materials and is entitled 'From 'imperfect' colloidal crystals to functional engineered nanophotonic architectures'. The second is entitled 'Metallodielectric colloidal crystal platform for plasmonic circuits and optical transformations ' and addressing key issues associated with novel device operation. The third is devoted to the idea of organising two Summer Schools, one in Europe and one in Japan, thus disseminating the most up-to-date knowledge available. The School(s) intend to cover the area of the interaction between light and a range of optically-active materials under differing conditions, while they will also focus on possible applications of these materials.",Photonic Applications of Nanoparticle Assemblies and Systems,FP7,31 December 2015,01 January 2012,146600.0 PHANTOM,Tel Aviv University,photonics,"In the strong light-matter interaction regime, a quantum emitter exchanges energy with an electromagnetic resonator in a reversible, coherent manner. In this unique situation the separated wavefunctions of the two entities are no longer the eigenstates of the Hamiltonian and one resorts to a 'dressed atom' approach, where the degenerate energy level splits into two new coupled states. Similarly, dye molecules embedded in a photonic nanostructure may interact resonantly with it to produce a hybrid system with new energetic states known as cavity-polaritons. The formation of such mixed light-matter states is a subject of on-going research since the mid 1980's, studied with atoms, semiconductors, electronic spins in NV centers and more. However, with organic molecules, new opportunities arise, which lay at the interface between physics and chemistry: the creation of new states and the rearrangement of the molecular energy landscape can modify chemical and material properties. This is a new concept, recently introduced, and which may be used for tailoring material properties for specific purposes. In this proposal I will pursue several avenues under the framework of strong interactions of molecules and light, and in particular I will development novel methods to control chemical reactions by strong coupling. I will examine the use of the coupling to plasmonic nanostructures for manipulating the triplet formation in organic dyes. By that I will be able modify the branching ratio for various processes in such molecules -phosphorescence quantum yield or chemical reactions evolving through the triplet state. In addition, I will study the transport properties of molecular films strongly-coupled to surface plasmons, and the spatio-temporal dynamics of such hybrid systems. The generality of the ideas in this proposal makes them significant to a wide range of organic-based systems and applications -light emitting/harvesting devices, photosynthesis, photo-oxidation and more.",Photophysical Applications of Nano-Optics to Molecules,FP7,31 July 2017,01 August 2013,100000.0 PHARMENG,Graz University of Technology * Technische Universität Graz,health,"Traditionally, empirical methods are used in the life-science industry to discover new drugs. Therapeutic effectiveness or bioavailability are determined mostly by trial and error - even today. However, rational discovery of drugs is beginning to revolutionize the industry. Unfortunately, the same cannot be said for the manufacturing of the final drug product - despite the fact that drugs are complex products, with a number of engineered features. Also, new drugs coming to the market are larger molecules, which are designed to be a complex, three-dimensional molecule to targets specific enzymes or cell surface receptors. This current trend is called the advent of the 'large-molecule drugs'. Large-molecule drugs, however, have one setback. They are difficult to make, and often it is nearly impossible to deliver them to the body. Thus, significant scientific know-how and expertise is required to make a drug into a product, i.e., there is a compelling need to apply engineering and science principles to this industry. The proposed program of the Marie Curie Chair (MCC) addresses exactly this issue, i.e., how to make a product from a newly discovered molecule. The research program will be a unique, multi-disciplinary combination of quantum-computational chemistry, experimental chiral catalysis, molecular design, and cutting-edge computer DNS simulations of multi-phase reactive flows in pharmaceutical processes. The MCC also proposes a strong educational program combined with out-reach initiatives to disseminate his work to a broad audience, and to train young researches in a relevant and new area. This initiative lies also well within the scope of the Graz University of Technology to form a Life-Science Engineering Center that includes areas such as advanced materials, bio-catalysis, reaction and bio-engineering, and nano-technology. In all activities the MCC will specifically address the need to foster women in science and engineering, as he has done in the past.",The Reaction Engineering of Pharmaceuticals: Efficient Production of Complex Drug Molecules,FP6,31 August 2008,01 September 2005,665557.0 PHAROS,Thales SA,photonics,"Planar photonic crystals are dielectric nanostructures that are pursued worldwide as a platform for integrated nanophotonic circuits. Such circuits will process signals coded in light and will consist of thousands of basic components such as resonant nanocavities. At present, unavoidable nanometer-scale disorder makes such large-scale integration impossible. Disorder causes the resonances of the nanocavities to shift randomly, resulting in Anderson localization, an interference effect that blocks the propagation of light. Anderson localization -predicted in 1958 by Nobel Prize winner Philip Anderson -is an intriguing scientific phenomenon as well as a serious threat to applications. I propose to create adaptive nanophotonic systems. In these systems, I will use a spatially modulated light beam to modify the resonance frequency of each individual nanocavity. After adaptive tuning, the spatially structured light exactly counteracts the disorder and guides signals safely through the nanophotonic circuit. Effectively the signals will propagate in a perfect nanophotonic structure. As a second main innovation, I will employ an ultrafast structured light beam to write new, ordered and functional patterns into the circuit. This transformational technology will enable applications wherein optical circuits become fully programmable. The circuit will be modified dynamically in less time than that needed for a photon to pass through it. Spatial light modulators will enable us to address and control thousands of individual nanophotonic components. Our dynamic and adaptive nanophotonic system will enable new technology, such as dynamically tunable delay lines, and open up new regimes of light propagation: the crossover regime of Anderson localization, ultraslow light that propagates scarcely faster than sound, and dynamic light propagation where the time dependence of the nanostructure drastically influences the flow of light.",Guiding Light through Disorder in Adaptive Photonic Resonator Arrays,FP7,30 September 2016,01 October 2011,1496400.0 PHASE,University of Birmingham,manufacturing,"This project aims to evaluate the effect of phosphonic acid adsorption on metal surfaces. Much is known about the adsorption of these molecules on oxide surfaces but very little is known about their behaviour on metals. The first primary aim is to determine adsorption and phase behaviour quantitatively as a function of surface charge, which will be controlled by varying applied electrical potential. A strategic combination of classical electrochemical and modern surface analytical probes will be employed, including atomic force microscopy and the recently developed in situ infrared technique, PM-IRRAS (Polarisation Modulation Infrared Reflection Absorption Spectroscopy). These results will be combined together with computational simulations, a combination of density functional theory and molecular dynamics simulations, to form a complete picture of the surface aggregation phenomena of these molecules. The strategy will be to evaluate the phosphonic acid behaviour first on single crystal substrates and then on nanoparticle surfaces, which will be prepared on carbon substrate by electrodeposition. The second primary aim of the proposal project is to evaluate the effect of adsorption of these molecules on the electrochemical reduction of oxygen (ORR), a reaction of immense technological importance. Phosphonates have previously received very limited study for fuel cell and battery applications. We aim to determine whether phosphonic acid adsorption can be used as a tool to direct the selectivity of the ORR toward a specific product. If the reaction can be steered toward peroxide formation rather than water, this would open up possibilities for the commercial production of hydrogen peroxide (using existing fuel cell technology) and Li-air batteries, where the peroxo product is preferred to permit the re-charging of the battery.",Phosphonic Acids: Surface Electrochemistry,FP7,,,221606.4 PHAST-ID,University College Cork,health,"Point-of-care testing is essential to provide better patient care by aiding physicians in making informed decision during patient visits. This will enable the start of immediate treatment for many conditions and reduce the strain on resources in secondary care, resulting in reduced outpatient clinic time. A key challenge in the development of point-of-care diagnostic devices is the requirement for robust, rapid and simple assay formats with direct readout, coupled with small sensing areas (~10 x 10 µm) and low sample volumes (25 µl) that exhibit the same sensitivity as laboratory based tests. The RAPID project will address this challenge by developing an integrated multichannel 2D photonic crystal based disposable biosensor and bench top reader, for point-of-care disease diagnostic applications. The RAPID disposable sensor will demonstrate enhanced performance beyond the state of the art in key proteomic diagnostic systems by delivering direct robust label-free detection of four pancreatic cancer serum biomarkers at less than 100 fM (5 pg/ml) concentrations. Objective genetic algorithms will be developed for infometric and chemometric pattern recognition to allow unequivocal identification of protein cancer biomarkers following collection of the data from the sensor platform. In this manner, the project will support the development of future device innovation in proteomics and disease diagnostics that could yield revolutionary advances in healthcare and nanomedicine. A successful RAPID project will provide a number of clear benefits over the current label-free commercial offerings: speed, cost and ease of use and make the outputs of the RAPID project very attractive commercially in the PoC diagnostic markets.","Robust, affordable photonic crystal sensors for point-of-care disease diagnostics",FP7,31 March 2014,01 September 2010,2680000.0 PHAT,University College Cork,photonics,"Two-dimensional photonic crystals (PhCs) in waveguide geometry are a recent concept for light propagation control, which has seen its main promises verified in the optical range. They have the potential to be the building block of a novel generation of optical circuits combining high-speed processing and very high scale integration. However, for the control of light emission, these 2D PhC suffer from a lack of confinement in the third (vertical) dimension. In this context, three-dimensional issue of nanostructuring, thanks to their bottom-up approach. The purpose of the present experimental and theoretical proposal is to benefit from the versatility and manufacturability of silicon to realize hybrid architectures combining 2D planar PhCs and self-assembled 3D PhCs. The goal is to provide conceptual tools to design advanced photonics architectures combining integrated light sources and routing functions for telecommunications wavelenghts. The basic issues addressed will be spontaneous emission control in 3D PhCs, routing functions in 2D PhCs, electrical addressing of PhCs, and coupling between 2D and 3D PhC in hybrid architectures. The present project will address many of the main targets of the thematic priority In-formation Society Technologies, such as the access to all part of the society to the information, by mean of user-friendly and secured services.",Photo Hybrid Architecture based on two- and three-dimensional silicon photonic crystals,FP6,28 February 2007,28 December 2003,1498250.0 PHD4ENERGY,Lund University * Lunds Universitet,energy,"One of Humanity's most urgent and greatest scientific and technological challenges is the need for more efficient methods to access renewable energy sources and ways to reduce energy consumption. Nanotechnology opens up fundamentally novel routes to address these challenges. With focus on the unique opportunities offered by III-V nanowires and molecular engineering, PhD4Energy will develop (i) highly-efficient, cost-effective, and flexible NW solar cells, (ii) cost effective, phosphor-free LEDs for RGB and lighting with optimised color rendering index and very low energy consumption , (iii) practical methods to enhance the thermoelectric performance of nanomaterials, and we will (iv) pioneer the use of Nature's choice of material (proteins) for direct chemical-to-mechanical energy conversion in artificial molecular machines. Furthermore, PhD4Energy will concurrently evaluate the safety and sustainability of our novel nanomaterials and device fabrication. In order to train early-stage researchers in the skills and methods necessary for succeeding with the proposed research and its industrial applications, PhD4Energy builds an innovative doctoral program (IDP) that with 9 partners from the private sector, combines high-level, interdisciplinary research with an extensive secondment program. The IDP will be designed to last beyond the tenure of PhD4Energy, and will serve a best-practice model for PhD education that effectively bridges the gap between academic research and in-terest of commercialization. A key feature of the training program is the direct input of industry leaders on the students' course menu, greatly enhancing employability. The training program will be embedded into the major materials science research hub at Lund in Sweden, comprising of the Nanometer Structure Consortium at Lund University, the synchrotron Maxlab, the future ESS spallation source, and a cluster of spin-off companies that actively pursue commercialisation of nm based research.","Nanoscale Materials for Energy: Fundamentals, Applications and Safety",FP7,31 January 2018,01 February 2014,3184248.0 PHELIX,Universiteit Twente * Twente University,photonics,"Supramolecular helices are a striking expression of chirality which is found at every level of biological materials, from plant cell walls to bones. Helical biomaterials formed out of equilibrium display multiple length scales, adaptation of structure to function and responsiveness to changing environments, a unique set of features that constitutes a fascinating source of inspiration for materials science. However, matching the complexity of these biological architectures by rational design of synthetic systems remains a major contemporary challenge. The aim of this project is to develop sophisticated helical materials with responsive architectures that are of interest in optical communication, energy management, photonic materials and mechanical actuation. The innovative and versatile approach proposed here consists in using light i) to engineer the period, handedness and orientation of the cholesteric helix, and ii) to stabilise the structures formed out of equilibrium by in-situ formation of polymer networks. Three tasks will run concurrently: Task 1: Stimuli-responsive infrared super-reflectors Task 2: Dynamic templates for long range ordering of nano-objects Task 3: Photomechanical actuation of helicoids and spiral ribbons 'Phelix' will yield complex systems that reach beyond the state of the art in stimuli-responsive materials, push the frontiers of research on supramolecular helices and shed new light on transmission of chirality across length scales. Ultimately, the omnipresence of helical structures in nature means that biomedical applications could be envisioned also. The proposal builds on my recent investigations on light-responsive helices in cholesteric liquid crystals. I have demonstrated the expertise in liquid crystals, photochemistry and microscopy required for this research and my leadership experience ensures its success.",Photo-Engineered Helices in Chiral Liquid Crystals,FP7,31 October 2017,01 November 2012,1496400.0 PHENOFIX,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"Genetically identical cells that live in a homogeneous environment often show substantial variation in their biological traits; such variation is called phenotypic noise. The level of phenotypic noise has a genetic basis, suggesting that higher levels of phenotypic noise can evolve. In fact, recent theoretical studies suggest that phenotypic noise could be a mechanism for a population of genotypes to respond to uncertain environments in a more efficient way than with conventional signal transduction pathways. However, it is not known if phenotypic noise is relevant for bacterially-driven processes in the environment, because the few studies that experimentally investigated phenotypic noise in bacteria did not consider metabolic activities that contribute to biogeochemical cycles. While it has been observed with novel nanoSIMS (nano-scale secondary ion mass spectrometry) technology that bacteria display phenotypic noise in metabolic activities, direct experimental evidence that phenotypic noise in metabolic activities has a biological function and can provide isogenic bacterial populations with a growth advantage is missing on a single-cell level. Moreover, it has not been experimentally tested if phenotypic noise in metabolic activities adapts over evolutionary timescales in response to fluctuating environmental conditions. The goal of this project is to experimentally investigate how phenotypic noise affects bacterial metabolic activity, growth and evolution under fluctuating environmental conditions. The proposal focuses on phenotypic noise in N2-fixation in the unicellular aquatic bacterium Klebsiella pneumoniae. The experiments will combine time-lapse microscopy, nanoSIMS and experimental evolution to understand why bacteria display phenotypic noise in metabolic activities. This will establish a link between the behaviour of single cells and biogeochemical cycles, and reveal how variation at the single-cell level can impact processes at the ecosystem level.",Biological Function and Evolution of Phenotypic Noise in N2-fixation on the Single-cell Level,FP7,30 April 2014,01 May 2012,178101.0 PHOCSCLEEN,Jules Verne University of Picardie * Université de Picardie Jules Verne,energy,"The research purpose of PHOCSCLEEN is to investigate a number of photo-catalytic oxide nanomaterials, classify them and produce new composite materials with tailored properties. Selected materials will be investigated in the light of application aimed to environmental clean-up and water splitting for hydrogen production. By exploiting the complementarities of partners, the following goals will be reached: 1. Improvement of the technical knowledge in the area, achieved thanks to a systematic characterization of the properties and processing of photo-catalytic oxide nanomaterials, and by investigating and optimizing the integration schemes of optical energy sources within the photocatalytic reactor, 2. Increase of the cooperation among the participating institutions and, more in general, between Europe, Canada and Mexico in this area; besides the support to the joint research among senior researchers (ERs), this will be achieved by training young researchers (ESRs) not only from a scientific point of view, but also enhancing their ability to work within an international team combining expertise coming from different research centers; 3. Support to and ease of the transfer of the existing expertise from one partner to another, both in terms of knowledge, and in terms of expertise on tools and processes. Eventually this will lead to the creation of a structured network of institutions cooperating in this area. This will also include the transfer of know-how in project setup and management to allow for the construction of a stronger management base to better define and guide future EU projects on the mentioned research area.",PHOtoCathalytic Systems for CLean Energy and Environment Applications,FP7,31 October 2016,01 November 2012,163800.0 PHOENIX,AIMPLAS - Plastics Technology Centre * Asociación de Investigación de Materiales Plásticos y Conexas,health,"Electrical and electronic (EE) applications -including housings, wire and cable, and internals such as connectors-are the largest market for flame retardants (FR) in plastics globally. The need for flame retardancy is increasing due to electronics miniaturization and higher temperatures in both processing and use. PHOENIX project is an ambitious multidisciplinary innovative threefold approach to develop: (i) A new concept of FR nanostructured materials, based on new non-halogenated flame-retardants applying nanotechnology to replace hazardous chemicals to produce sustainable FR additives based on nanolayered structures and modified lignins, produced with innovative and green chemical routes, for thermoplastic and thermoset applications. (ii) Innovative processing routes, providing solutions to the demands of the EU Industry regarding FR, finding a true cost-effective and sustainable alternative to existing non-environmentally friendly HFR, which allows simultaneously a significant improvement of mechanical properties and processability, highly limited with the existing non-halogenated FR available in the market for compounding, extrusion and injection moulding processes. New compounding techniques such as Nanodirekt process, and high innovative systems, such as ultrasounds mixing systems coupled to extrusion and injection equipments, will assure high nanoparticles dispersion in the polymer nanocomposites and in the final pieces, thus achieving optimal properties. (iii) Simulation and modelling of compounding processes for the preparation of optimal nanocomposites, avoiding aggregates and achieving the best dispersion of the nanoparticles in the polymer matrix. The achievement of these results will represent a significant advantage to the participating SMEs and in turn to the End-Users demanding high-performance environmentally friendly FR materials to manufacture high-performance parts.",Synergic combination of high performance flame retardant based on nano-layered hybrid particles as real alternative to halogen based flame retardant additives,FP7,31 December 2016,01 January 2013,5099936.0 PHOLOGIC,Polytechnic University of Valencia * Universitat Politècnica de València,energy,"The objective of PHOLOGIC project is to explore the mass-manufacturing compatibility of nonlinear photonic materials (CdTe and Si nanocrystals) and their associated fabrication processes with CMOS processing lines using a highly scalable photonic logic gate structure as functional validation device. For the sake of benchmarking a third technological approach based on InP planar photonic crystals is also addressed. The CdTe and Si-nc materials show excellent nonlinear features and their fabrication processes can be incorporated in an intermediate step within a CMOS processing line. The full optical characterisation of the materials and the optimisation of their fabrication processes will be carried out in the PHOLOGIC project, which will suppose a radical long-term innovation beyond current state-of-the-art and a clear innovation aimed at mastering nanophotonics for low cost. As a functional validation device an all-optical logic gate using a nonlinear Mach-Zehnder interferometer structure will be implemented offering key features for mass-manufacturing such as a high scalability and flexibility to implement advanced functional devices. Furthermore, photonic crystals as well as other periodic structures will be used to exploit the concept of slow waveguiding reducing thus the size and power requirements of the all-optical logic gate. A monolithic all-optical logic gate on InP based on a buried heterostructure integrating photonic crystals will also be produced for the first time in order to improve the degree of integration and to be used as a benchmarking action with respect to the other two technological approaches (CdTe and Si-nc). The technical assessment among the three proposed technological approaches will be carried by a Consultation Panel formed by several important companies (Si mass-manufacturers, equipment producers and foundries) that will provide evaluation and recommendations in terms of mass-manufacturing, reliability and optical performance.",Nanophotonic Logic Gates,FP6,30 September 2008,30 May 2005,2000000.0 PHOME,Foundation for Research & Technology Hellas (FORTH),photonics,"Metamaterials are composite, man-made materials, composed of sub-wavelength metallic building blocks, which show novel and unique electromagnetic properties, not occurring in natural materials. A particularly important class of such materials is the negative refractive index metamaterials (NIM). NIM have been in the foreground of scientific interest in the last seven years. In 2006-2007 near infrared and optical frequencies were obtained, despite the initial objections and disbelief. However, many serious obstacles have to be overcome before the impressive possibilities of optical/photonic metamaterials (PMM) can become real applications. The present project identifies the main obstacles and proposes specific approaches to deal with them; in addition, it intends to study novel and unexplored capabilities of PMM. Specifically, the project objectives are (a) realization of 3D PMM, (b) reduction of losses in PMM, (c) realization of active and tunable/switchable (electrically or optically) PMM by incorporating gain or nonlinearity, and (d) realization of chiral PMM. The accomplishment of those objectives is both a theoretical and a technological challenge, as it requires proofs of concepts, advanced computational techniques and advanced nanofabrication approaches. To guide and test the proposed PMM development effort we have identified a number of important and ICT relevant demonstrators, which include thin-film optical isolators, electro-optic modulators, optical switching, and NIM-based 'perfect lenses' in the infrared, and possibly in the visible. The implementation of the project will be done through combined theory/modeling, fabrication and experimental testing efforts, in continuous interaction. The broad theoretical and experimental expertise of the proposers, together with their field shaping past contributions to metamaterials, make them capable to face the challenges involved and to minimize the risk, ensuring the maximum possible success of the project.",Photonic Metamaterials,FP7,31 August 2011,01 June 2008,1431480.0 PHOMULDNAPOL,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"Cancer treatment and vaccine development represent two of the major challenges that contemporary medicine is confronted with. Although significant progress has been achieved in both fields, the present methodologies remain limited, in part due to the numerous specific requirements for each treatment. This proposal focuses on the development of a novel, versatile drug delivery system suitable for either purpose, combining multifunctionality and controlled molecular release using biocompatible materials. The proposed approach involves the use of self-assembled nanocarriers based on amphiphilic DNA block copolymers with a photodegradable linker (PL) as a junction point (DNA-PL-Pol). These nanocarriers combine the advantageous features of the constituents of the DNA-PL-Pol, i.e. the possibility of attaching multiple functionalities by DNA hybridization, the localized and controlled release of encapsulants by near-infrared irradiation (NIR) and the biodegradability of the polymers. The project involves on one hand the synthesis of DNA-PL-Pol and the study of their aggregation behavior and on the other hand, the testing of the systems in cancer treatment and vaccine development. The proposed work will cover diverse fields in scientific research, i.e. organic and polymer synthesis, physical organic chemistry, supramolecular chemistry, biochemistry, cancer therapy and immunology.",Photoresponsive multifunctional DNA block copolymer nanocarriers for drug delivery and vaccine development,FP7,30 June 2014,01 July 2011,236283.0 PHOQUS,University of Dundee,health,"The PHOtonic tools for Quantitative imaging in Cells and tissUeS IDP (PHOQUS) will seed a revolution in the development and application of novel imaging modalities and multimodalities to enable the quantitative investigation of biological processes at multiple size regimes from the molecular and cellular to the tissue and organ level scale, by training graduate Physicists and Biologists for the first time to integrate seamlessly photonics, nanotechnology, advanced spectroscopy and novel spectral regions with the latest advances in imaging and diagnostics technology. The photonics focus on new tools and sources will open up opportunities to investigate the mechanisms and nuclear dynamics that control spindle formation and chromosome separation during mitosis as well as cell migration dynamics and mechanics during early embryonic development and the development of cancer in the gut. This will provide a strong interdisciplinary component to the training programme, linking Dundee's extensive and world-class expertise in Life Science and pioneering work in the Medical School. The training programme will lead automatically to advances and new knowledge on how to harness these new technologies, and new strategies. PHOQUS is strongly intersectoral, with close involvement of 10 Associated Industrial Partners and 9 Academic distributed over 7 European countries. Imaging science is key for the success of any fundamental or applied research programme aiming to uncover the complexities of the life at multiple scales and to finding new solutions to diseases and conditions. By developing ESRs as a cohort they will avoid becoming isolated in between physics and biology, developing a true identity as interdisciplinary scientists: essentially 'problem oriented physicists' or 'solution oriented biologists'. PHOQUS aims to develop researchers with the correct mindset to discover and address the big problems in biology from an early stage in their research careers.",PHOtonic tools for Quantitative imaging in tissUeS,FP7,31 October 2017,01 November 2013,3816691.0 PHOREMOST,University College Cork,photonics,"It is proposed to establish a Network of Excellence in the area of Nanophotonics and Molecular Photonics to address the near- and long term needs of photonic functional components. PHOREMOST builds on the critical mass existing in Europe in this emerging area, rapidly developing as a result of the concomitant progress in nanostructured materials, nanofabrication technologies, nano-scale characterisation techniques, novel concepts linking electromagnetic radiation in electronic and optical systems, recent concepts involving optical properties of non-periodic, fractal and quasi-crystal structures, as well as a better understanding of non-linear properties of molecules. The main driving force behind nanophotonics is the expectation to access the molecular scale dispensing with electrical contacts. PHOREMOST will integrate the activities in the nanophotonics area of 34 pioneering and world- leading partners from universities, research centres and industry to: (a) overcome fragmentation, (b) ensure efficient use of resources, (c) identify future RandD opportunities, (d) guarantee the supply of suitably trained personnel, (e) anticipate future research needs, (f) ensure the excellence in research translates into applications in the life sciences, environment, infotainment and security, (g) benefit from the untapped expertise in accession and third countries and, (h) contribute to the public understanding of science. To achieve its objectives the Network organises its long-lasting impact work, into a synergetic JPA with integrating and spreading excellence activities. Its JPR consists of four strands: gaining functionality by incorporating nanostructures in microsystems, fabricating novel nanostructured materials and functionalising them and, finally, applying this new knowledge to photonic device realisations. The management activities are designed to ensure a smooth and efficient running of the network, to protect the knowledge generated and to monitor the JPA.",NANOPHOTONICS TO REALIZE MOLECULAR-SCALE TECHNOLOGIES,FP6,31 December 2008,30 September 2004,4700000.0 PHOSPHOR,University of Bristol,information and communications technology,"PHOSPHOR: PHOtophysics and SPectroscopy of Hydrides, ions and Organic Radicals Processes that convert electronic excitation into nuclear kinetic energy largely determine the photophysics of polyatomic molecules in excited electronic states. Such processes are ubiquitous - in scientific areas ranging from atmospheric chemistry to photobiology, and from molecular electronics to nanoscience. In the language of chemical physics, such processes represent a breakdown of the so-called Born-Oppenheimer approximation that underpins almost all of our thinking in the areas of molecular structure, spectroscopy and dynamics. Central to such thinking is the concept of the potential energy surface, on which reactants evolve to products. Recently evidence has been accumulating from both experimental and theoretical studies that the atoms and molecules can switch between electronic states during bond breakage and formation processes. Such processes are described as non-adiabatic and are driven by couplings between the ground and higher lying adiabatic PESs that are neglected within the Born-Oppenheimer approximation. This proposal seeks to apply cutting-edge laser based experimental techniques, particularly velocity map ion imaging methods and H (Rydberg) photofragment translational spectroscopy, to investigate details of the primary photophysics and photofragmentation physics of a carefully chosen range of molecules, organic free radical species, and state selected molecular ions. Each family of experiments involves innovative state-of-the- art experimentation, and will be backed up by detailed theoretical interpretation. In this way, we expect to accumulate detailed insights into the role of non-adiabatic effects in the fragmentation of different classes of molecular system (both closed-shell, and open-shell), thereby building towards a much fuller understanding of non-adiabatic couplings and their influence on molecular reactivity.","Photophysics and Spectroscopy of Hydrides, Ions and Organic Radicals",FP6,31 October 2005,01 November 2003,159613.0 PHOTBOTS,LABORATORIO EUROPEO DI SPETTROSCOPIE NON LINEARI,health,"The general goal is to bring together different fields of research in order to create a new research area of photonic micro robotics. That is to create, study, and implement truly microscopic structures with nano scale accuracy that can perform robotic tasks and that are entirely powered and controlled by light. This idea brings immense challenges both from the point of view of the physics involved as well as the chemistry needed to create the appropriate materials, but if successful can also have a huge impact. To achieve this, we will combine our expertise on complex photonic materials and direct laser writing, to create micro structured patterns in liquid crystal elastomers, which are rubber-like polymers with liquid crystalline properties that can be triggered with light. In our view, this opens up a new strategy to create robots of various kinds, on a truly micrometer length scale. That is, micro robots that can swim, walk, or crawl, and when at destination perform specific tasks, controlled and driven by light. This proposal, in the first instance, deals with fundamental, curiosity-driven research and wishes to address the wealth of physics and chemistry that arises when combining nano photonics with micro robotics. Having said that, the range of potential applications is very broad. Our photonic micro robots would be able to penetrate otherwise difficult to access environments and perform tasks such as sensing or sampling. They could be made in large quantities which means they could also be put into action collectively in swarms (using mechanical and/or optical interaction between the individual robots). The project is truly interdisciplinary, which makes it very challenging but also exciting. The photonic micro robotic structures will be created by bringing together concepts from physics and chemistry, while the inspiration for designs comes partly from biology and potential applications can be foreseen in medicine.",Nano Photonics-Based Micro Robotics,FP7,31 December 2016,01 January 2012,2200000.0 PHOTO-EM,University of Cambridge,energy,"The exploitation of renewable sources of energy is one of the biggest challenges of our time, with wide ranging implications in both Science and Society. The new generation of dye-sensitized solar cells and hybrid polymer-inorganic solar cells represents one of the most exciting developments in this field. These promising devices based on photoactive nanomaterials can be produced at low cost, but they have an overall power conversion efficiency of 10-12%, attributed to short charge carrier recombination times and diffusion lengths. If we hope to improve this performance we must learn how the solar cells behave at the nanoscale, under realistic working conditions. To achieve this I propose to study photovoltaic materials in the transmission electron microscope, under photon irradiation. The three main areas to pursue are: a) In situ illumination technique development, b) Study of physical properties of solar cells, c) Theoretical interpretation of the spectroscopy results. The work plan of this ERC project will follow different strands in parallel, so that we can explore this novel field more efficiently. Our in situ illumination technique will be exported to a new monochromated and aberration corrected transmission electron microscope with very high spatial and energy resolution. The ultimate challenge is to provide maps of the electronic properties and photovoltaic behaviour of a solar cell, in particular to evaluate –on the atomic level- the effect of grain boundaries and surfaces on the performance of the device. We will study both dye-sensitized and bulk heterojunction solar cells, starting from the individual nanostructured components, with the aim of producing working cross-section devices to be mounted and operated inside the electron microscope. Efficient data processing and theoretical interpretation of the microscopy results will be essential to the success of this process, so we will build capabilities in these areas to support and guide the experimental work. The team I want to lead in this scientific mission is ideally composed of a postdoctoral research assistant and two PhD students. The postdoc will take care of technique development and theoretical aspects, while the students will concentrate on the study of materials and devices.",Solar cells at the nanoscale: imaging active photoelectrodes in the transmission electron microscope.,FP7,30 November 2015,01 December 2010,1381541.0 PHOTOBIODRUG,Polytechnic University of Valencia * Universitat Politècnica de València,health,"Specific interactions between drugs and biomolecules are fundamental to many biological processes. It is well known that biomolecules can undergo extensive changes upon irradiation in the presence of drugs, which can behave as photosensitizers leading to adverse side-effects (e. g., to a loss of their biological function). Thus, protein-protein photocrosslinking, or drug-protein photobinding originating photoallergy, as well as DNA damage resulting in photomutagenicity and photogenotoxicity, are well known. Clearly, a precise knowledge of the active sites where drugs can interact with biomolecules and the involved reaction mechanisms would contribute to understanding the photosensitizing potential of new drug candidates. To address this issue, photophysical techniques (fluorescence and transient absorption techniques, from the femtosecond to the nanosecond time scales) will be used in order to get insight into the mechanisms involved in drug-DNA or drug-protein interactions as well as to improve the knowledge in the photochemical reaction pathways that can provoke damage to the biomolecule. To this end, model systems, whose complexity will be progressively increased, that simulate the real drug-biomolecule interactions, will be designed in order to study their photophysical properties and photochemical reactivity. Investigation on the mechanistic pathways leading to photodamage may thus contribute to the design of new therapeutic agents inducing less adverse side effects to the organism, which may have applications in pharmaceutical and skin photoprotection industries.",EXCITED STATES AS PROBES TO INVESTIGATE DRUG-DNA AND DRUG-PROTEIN INTERACTIONS. PHOTOSENSITIZED PROCESSES LEADING TO DAMAGE TO BIOMOLECULES,FP7,28 February 2015,01 March 2013,50000.0 PHOTOCAT,Weizmann Institute of Science,manufacturing,"Metal nanoparticles (NPs) have been studied intensely in the last decade due to their novel optical, catalytic and electronic properties. Because of the nanoscopic size of NPs, self-assembly has been by far the most important means of generating higher-order architectures. Light is a particularly attractive means to self-assemble of NPs because it can be delivered instantaneously and into a precise location. In order to render NPs photoactive, their surfaces need to be functionalized with photoresponsive ligands. As an incoming Independent Researcher at the Weizmann Institute of Science, the Applicant wishes to develop new nanomaterials resulting from this marriage of nanoscience and organic chemistry. The Applicant has extensive experience in the fields of nanoscience and organic chemistry, acquired during the last several years at Northwestern University, USA. In the proposed project, he would like to develop a NP-based system, in which catalysis is regulated by light. This system takes advantage of his previous research, which has shown that NPs can be reversibly assembled and disassembled using light (PNAS 2007, 104, 10305; Science 2007, 316, 261). For NPs decorated with mixed monolayers comprising photoswitches and molecular catalysts, disassembly of such aggregates will result in a drastic increase of a catalytic surface area exposed to the solvent, and therefore in effective catalysis of a model reaction. As a result, self-assembly process will be transduced into catalytic activity. The system will then be extended to include various types of NPs functionalized with mixtures of different photoswitches and catalysts. These NPs will assemble / disassemble when exposed to different wavelengths of light. The ultimate goal of the project is to demonstrate that in a complex mixture of mutually incompatible chemicals, reactions can be turned 'on' and 'off' using light of different wavelengths, in a way similar to enzymatic regulation of reactions in living cells.",Photoinduced Catalysis in a Nanoparticle System,FP7,10 July 2015,11 January 2009,100000.0 PHOTOCATMOF,University of Liverpool,energy,"This project is proposed to enhance hydrogen generation form metal-organic frameworks (MOFs) for photocatalytic water splitting via dye sensitization. Solar energy-driven renewable hydrogen could transform the supply of carbon free fuel and make an enormous impact on the viability of hydrogen as an energy carrier. Secondary building units (SBUs) in MOFs are typically comprised of transition metal oxide/nitride coordination units that can be considered as semiconductor quantum dots and thus MOFs are regarded as a matrix of such quantum dots. Although MOFs have exhibited the photocatalytic activity for water splitting, the apparent quantum yield is low because of large band gaps of SBUs. Suitable dyes are employed to sensitize the SBU semiconductor quantum dots via post-synthetic modification to enhance the capability to capture visible light, by integrating the concept of dye-sensitized semiconductor into MOF-based photocatalyst. Porosity of MOFs makes it possible to adsorb water molecules inside of free pore space which is expected to capture photoinduced electron for hydrogen generation. This system is well suited for the mechanism study due to the self-containing water molecules. In contrast, water can only be adsorbed on surface of the dense bulk semiconductor via weak interaction. This project stands at the intersection between MOF chemistry and semiconductor science. MOF provides a semiconductor quantum dot matrix and they are stable and free from agglomeration due to the strut of organic linkers, which is the drawback of for bulk and nanosized semiconductor materials. And the quantum effect of SBUs will play a great effect for the photocatalytic performance. Dye sensitization of MOFs fully adopts the merits of both MOF and semiconductor and overcomes their respective drawback for photocatalysis. The scientific and technological strengths identified between the researcher and host, Professor Rosseinsky, University of Liverpool is well aligned to the project.",Dye-Sensitized Metal-Organic Frameworks for Photocatalytic Water Splitting,FP7,31 March 2014,01 April 2012,209033.0 PHOTOMAT,Polytechnic University of Turin * Politecnico di Torino,information and communications technology,"This project aims at developing new materials with tunable properties, conjugating good mechanical properties and photocatalytic activity. New and advanced materials will be synthesized on purpose, characterized and their efficiency as photocatalysts in abating pollutants such as pesticides and emerging pollutants will be evaluated.","TUNABLE MATERIALS: PREPARATION, CHARACTERIZATION AND INVESTIGATION OF PHOTOCATALYTIC ACTIVITY OF NEW HIBRID MATERIALS",FP7,08 July 2017,09 January 2012,0.0 PHOTOMEM,ECOSYSTEMS srl,environment,"Presently available methods for the treatment of olive mill waste water are not acceptable from the environmental point of view (evaporation, discharge) or not suitable from the economic aspect (membrane treatments) costing 10-20% of revenues from oil selling. PHOTOMEM proposes a reliable and affordable technology solution to treat the waste water, applying a novel technical solution based on degradation of organic pollutants through photocatalysis. Dispersed ferromagnetic titania nanoparticles with a magnetic core will be used in a photocatalytic reactor and recovered through a magnetic filter. A subsequent membrane filtration step will be used to achieve the COD limit for reuse of the recycled 85% of wastewater as purified water to a grade compatible with irrigation use and/or dischargeable at low cost in the civil municipal sewer system. The combination of the 2 processes will grant strongly improved performances: double membrane lifetime, 50% cost saving for the operation, 3 times more compact plant, much faster operation. The recovery of polyphenols, a family of added value compounds (hydroxytyrosol) present in the wastewater will be performed to make the process more profitable. The tangible outcomes of the PHOTOMEM project will be: 1. Production process for ferromagnetic photocatalytic titania nanoparticles, 2. Economical wastewater treatment for OMWW, 3. PHOTOMEM pilot plant of 1 m3/day capacity to validate the treatment and evaluate scale-up. The 2 SMEs (ECS, BIOAZUL) specialised in waste water treatment plants design and construction will sell the PHOTOMEM plant in 2 different countries (Italy, Spain). The producer of custom-made ceramic powders and nanostructured materials for industrial use (MT) will produce the ferromagnetic photocatalytic titania nanoparticles. The end-user (FRA) will apply the technology in its production site. The market potential for such a solution would be of the order of several tens of millions of Euro.",Photocatalytic and membrane technology process for olive oil mill waste water treatment,FP7,11 June 2014,12 January 2010,909935.75 PHOTOMETA,Foundation for Research & Technology Hellas (FORTH),photonics,"Novel artificial materials (photonic crystals (PCs), negative index materials (NIMs), and plasmonics) enable the realization of innovative EM properties unattainable in naturally existing materials. These materials, called metamaterials (MMs), have been in the foreground of scientific interest in the last ten years. However, many serious obstacles must be overcome before the impressive possibilities of MMs, especially in the optical regime, become real applications. The present project combines NIMs, PCs, and aspects of plasmonics in a unified way in order to promote the development of functional MMs, and mainly functional optical MMs (OMMs). It identifies the main obstacles, proposes specific approaches to deal with them, and intends to study unexplored capabilities of OMMs. The project objectives are: (a) Design and realization of 3d OMMs, and achieve new metasurface designs applying Babinet's principle. (b) Understanding and reducing the losses in OMM by incorporating gain and EM induced transparency (EIT). (c) Achieving highly efficient PC nanolasers and surface plasmons (SPs) lasers. (d) Use chiral MMs and SPs to reduce and manipulate Casimir forces, and (e) Using MMs, combined with nonlinear materials, for THz generation, and tunable response.(f)Calculate electron- phonon scattering and edge collisions in graphene and in graphene-based molecules. The unifying link in all these objectives is the endowment of photons with novel properties through imaginative use of EM-field / artificial-matter interactions. Some of these objectives seem almost certainly realizable; others are more risky but with higher reward if accomplished; some are directed towards new specific applications, while others explore new physical reality. The accomplishment of those objectives requires novel ideas, advanced computational techniques, nanofabrication approaches, and testing. The broad expertise of the PI and his team, and their pioneering contributions to NIMs, PCs, and plasmonics qualifies them for facing the challenges and ensuring the maximum possible success of the project.",Photonic Metamaterials: From Basic Research to Applications,FP7,28 February 2018,01 March 2013,2100000.0 PHOTON,Paul Scherrer Institute,energy,"Materials define progress. Organic-inorganic hybrid materials based on the perovskite crystal structure have recently attracted a great deal of attention in the field of new and emerging photovoltaics, where photo-conversion efficiencies of over 15% have been demonstrated (with independent verification at 14.1%). These recent developments are the first examples of a truly low-cost photovoltaic system based on earth-abundant materials yielding efficiencies that are competitive with traditional photovoltaic technologies. It was recently shown that photovoltaics based on hybrid perovskites can operate in a thin-film architecture. The thin-film architecture enables simplified processing, potentially better control, provided the method of processing is carefully chosen, and a greater availability of analytical tools compared to solution processing. Crucially, it is possible to transfer over 30 years of existing, proven thin-film photovoltaic technology into the new system such as photonic management in light-trapping techniques and a whole host of electronic contact engineering knowledge thus rapidly progressing State of the Art. Understanding thin-film formation and properties is paramount to the development of this technology beyond the State of the Art. The application of advanced thin-film deposition techniques such as pulsed-laser deposition allows the formation of atomically smooth films and crucially it allows control over the material stoichiometry and composition, thereby enabling control over material properties. Furthermore, sophisticated instrumentation to monitor thin-film growth in-situ thus allowing the researcher to carefully probe the processes in thin-film formation exists. Another imminent challenge is to gain control over the material crystallisation and film formation, achieving this will lead to better reproducibility thus help devise realistic industrial scale-up strategies",Perovskite-based Hybrid Optoelectronics: Towards Original Nanotechnology,FP7,31 May 2016,01 June 2014,199317.0 PHOTON-PLASMONHYB,Imperial College London,photonics,"The main objective of this proposal is on exploring the synergy of the two cores of nanophotonics technologies, i.e., silicon photonics and plasmonics, which have been identified as one of the key competitiveness of European research and economic sectors. [The Leverage Effect of Photonics Technologies: the European Perspective. By European Commission] The project addresses hybrid structure composing of a silicon microring (MR) or microdonut (MD) resonator coupled with a plasmonic nanoantenna. The presence of the nanoantenna, with its controllable and enhanced local electromagnetic fields, will allow controlling the optical properties of MR or MD via near-field coupling, but which is achievable through far-field excitation. Many degrees of control over the optical property of the MR or MD are achievable via the polarisation state of the far-field source, and size, shape, orientation and placement of the nanoantenna with respect to the MR or MD. The underlying physics behind the photon-plasmon coupling will be investigated with an aim of achieving design rules for photonic-plasmonic hybrid structure. Furthermore, the proposed hybrid structure will be demonstrated for use as an optical switch and a biosensor. The generated research outcomes will be relevant to the EU in two main respects: first, they will help advance the fundamental knowledge concerning the physics behind the coupling between silicon photonic structure and plasmonic nanoantenna, which will strengthen the position of EU as the world's leader in the field, towards making it the hub of scientific research and, second, the design has potential for intellectual property protection, thus, enhance EU's industrial competitiveness by giving its an edge in the marketplace.",Photonic-plasmonic hybrid for optical switching and biosensing application,FP7,31 August 2016,01 September 2014,231283.0 PHOTONANOFLUIDIX,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"We have demonstrated the presence of attractive interactions arising in low ionic strength solution between charged soft-matter objects and highly curved regions of like-charged confining surfaces. These unexpected interactions result in stretching of DNA and trapping of colloidal particles in solution in a nanofluidic slit. This proposal seeks to further understand the attractive interactions arising between colloidal objects and like-charged confining walls in low-ionic-strength solution, in order to better control the underlying self-assembly process. The controlled self-assembly of arrays or arbitrary arrangements of discrete charged metal or dielectric nano-objects will permit the investigation of plasmonic and photonic phenomena in two dimensions, e.g., plasmonic coupling of resonantly excited metal nanoparticles, modification of fluorescence emission of single emitters diffusing in solution very close to discrete metal nano-objects, realization of novel ordered and disordered arrangements of nano-objects (e.g. dielectric particles like TiO2) for studying light scattering phenomena in two dimensions. One of the chief advantages of the self-assembly technique described here over conventional fabrication techniques is that the substrate surface structure which directs self-assembly of the optically active element acts as a 'rewritable surface' enabling the investigation of the plasmonic and photonic properties of ensembles of particles of similar surface charge but variable dielectric properties.",Self-assembly of confined colloidal objects for the study of nano-optic phenomena,FP7,30 April 2011,01 May 2009,250701.0 PHOTONANOTECH,Sofia University * Sofiiski Universitet Sveti Kliment Ohridski,health,"The photozymes (P) are amphiphilic water-soluble copolymers consisting of hydrophobic chromophoric and hydrophilic monomer units forming nanosized pseudo-micelles which hydrophobic core allows to transfer the solar energy into chemical energy due to the antenna effect (AE) with singlet oxygen production (SOP) and the tailored photochemical transformation of the solubilized in the hydrophobic pocket molecules. The co-existence of these two distinctive for the photosynthesis effects in P opens wide range of possible technological innovation developments. The goal of PhotoNanoTech (PNT) is to develop new nano-based processes with long-term applications in the wastewater decontamination (WD), textile processing, biomedical coating and materials development, as well as for bone regeneration. New P will be synthesized to this goal, using zwitterionic (ZI) monomers providing them specific antipolyelectrolyte properties, salt-philicity as well as an unique self-org! anization ability (SOA), similar to that of phospholipids (PL). AE-induced chemical reactions of the solubilized hydrophobic compounds is the fundament of P applications for the photocatalytic WD. pH-independent photocatalytic WD from dissolved hydrophobic compounds and damaging inorganic salts are the advantages of the suggested ZI P. The combination of AE and SOP could find a new and promising application for making self-cleaning textiles. PL vesicles are the place for the calcium phosphate nuclei formation and grow. PNT will exploit SOA of ZI P for their participation in the biomineralization (BZ) process. Photosensitizing characteristics of ZI P included in such vesicles opens the opportunity for light-controllable BZ, called photodynamic BZ. A valuable property of ZI-based materials is their biocompatibility. PNT includes the production of such materials (by photoinduced graft-copolymerization) with suppressed inflammatory response, enhanced biolubrication characteristics and haemocompatibility.","Photozyme Nanoparticle Applications for Water Purification, Textile Finishing, Photodynamic Biomineralization and Biomaterial Coating",FP6,31 March 2010,01 April 2007,1547100.0 PHOTONICENTANGLEMENT,Heidelberg University * Ruprecht-Karls-Universität Heidelberg,information and communications technology,"Photonic entanglement plays a crucial role both in fundamental tests of quantum mechanics and in quantum information processing (QIP). Remarkably, recent theoretical and experimental advances have shown the possibility to exploit multi-photon entanglement for efficient QIP using only linear optics together with projective measurement. Building on our long experience in research on entanglement from spontaneous parametric down-conversion, the main purpose of the present project is to perform a number of significant experiments in the field of QIP with particular emphasis on linear optics quantum computation, long-distance quantum communication and new test of multi-party quantum locality. Within the project, we plan to experimentally investigate the potential application of a photonic logic gate with classical feed-forwardability; we plan to exploit free-space entanglement distribution to perform experimental demonstration of long-distance quantum teleportation and quantum cryptography on the order of ten kilometre to penetrate the limit of aerosphere; we plan both to exploit multi-qubit code to experimentally investigate the possibility to overcome the decoherence caused by the channel noise and, to exploit entanglement swapping to investigate the possibility to solve the photon loss in the quantum channel; moreover, we also plan to perform a demonstration of high efficiency quantum cryptography with high-dimensional entanglement; and finally we plan to exploit a high-intensity three-photon entanglement source to perform long-distance third-man cryptography, secret sharing and test of quantum nonlocality. The techniques that will be developed in the above experiments will lay the basis for future large scale realizations of linear optical QIP.",Experimental manipulation of photonic entanglement for linear optics quantum information processing,FP6,30 April 2008,01 May 2005,1161587.0 PHOTONICROADSME,Steinbeis Innovation gGmbH,photonics,"In the next ten years scientific developments in the field of nanophotonics as a key driving force in photonics will influence many different industrial branches e.g. automotive and avionics, industrial automation ICT, health and well-being, environment or safety and security. In these industrial sectors many SMEs are involved as traditional suppliers, start-ups or producers of high tech products. In order to remain competitive on these markets, the companies have to integrate these new results and developments in their commercial vision for future products. The project PhotonicRoadSME will develop technology roadmaps roadmaps to identify future RTD strategies for Europe in three domains [related nanophotonic materials / novel photonic devices and components / related key fabrication technologies] comprising the latest high level scientific results. Their functions will be a. to identify trends in research and development and b. to associate them to product and application visions. They will outline, which of them are technically and economically promising or possess high potentials for problem-solving and where potential risks and relevant investigation requirements are assumed or social discussion requirement could prevail. Therefore, four different industrial branches will be analyzed (ICT, health and well-being, environment and safety and security). The validation of the roadmap results will be done by a consensus building process by integrating industrial and scientific experts from Europe and third countries. In a second step these roadmaps will be adapted to the SME industrial culture in order to facilitate the integration of the European photonic RTD results in the different industrial branches. The project involves well-known European research organisations and networks, which are leaders in the domain of photonics, European experts in the development of technology roadmaps and organisations from 5 European countries.",Development of Advanced Technology Roadmaps in Photonics and Industrial Adaption to SMEs,FP7,30 September 2010,01 May 2008,799981.0 PHOTONVOLTAICS,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,energy,"The ambition of PhotoNvoltaics is to enable the development of a new and disruptive solar cell generation resulting from the marriage of crystalline-silicon photovoltaics (PV) with advanced light-trapping schemes from the field of nanophotonics. These two technologies will be allied through a third one, nanoimprint, an emerging lithography technique from the field of microelectronics. The outcome of this alliance will be a nano-textured thin-film crystalline silicon (c-Si) cell featuring a drastic reduction in silicon consumption and a greater cell and module process simplicity. It will thus ally the sustainability and efficiency of crystalline silicon PV with the simplicity and low cost of the current thin-film solar cells. The challenge behind PhotoNvoltaics lies behind the successful identification and integration of these nano-textures into thin c-Si-based cells, which aim is a record boost of the light-collection efficiency of these cells, without harming their charge-collection efficiency. The goals of this project are scientific and technological. The scientific goal is two-fold: (1) to demonstrate that the so-called Yablonovitch limit of light trapping can be overcome, with specific nanoscale surface structures, periodic, random or pseudo-periodic, and (2) to answer the old question whether random or periodic patterns are best. The technological goal is also two-fold: (1) to fabricate thin c-Si solar cells with the highest current enhancement ever reached and (2) to demonstrate the up-scalability of this concept by fabricating patterns over industrially relevant areas. To reach these goals, PhotoNvoltaics will gather seven partners, expert in all the required fields to model and identify the optimal structures, fabricate them with a large span of techniques, integrate them into solar cells and, finally, assess the conditions of transferability of these novel concepts, that bring nanophotonics into PV, further towards industry.",Nanophotonics for ultra-thin crystalline silicon photovoltaics,FP7,31 October 2015,01 November 2012,2894454.0 PHOTOPATTTOCELL,Graz University of Technology * Technische Universität Graz,health,"While photolithographic techniques are well established for patterning of semiconductors, they have not been employed for polysaccharide based materials to a large extent. The main idea of this project is to generate nano-patterned cellulose thin films using ideas and concepts from semiconductor industry to create 2 and 3 dimensionally structured cellulose surfaces. As starting material for the generation of cellulose surfaces, trimethylsilyl cellulose (TMSC) containing (2-photon sensitive) photoacid generators (PAG) is used which is deposited on different kinds of surfaces by spin coating. The use of mask aligners and UV-light or 2-photon absorption lithography converts exposed areas to cellulose (silyl groups are cleaved off by the generated acid) while in the unexposed areas TMSC remains. After the patterning step, TMSC can be selectively dissolved using an appropriate solvent or, alternatively, the converted cellulose can be digested using cellulases. Using the latter route remaining TMSC can be converted to cellulose in an additional step. As a result, 2 and 3 dimensionally nanostructured films can be obtained which have a large potential as material for semiconductor industry, in medicine (for growth of stem cells, antifouling materials) and in optical materials (refractive index changes). While the main focus of the project is to generate nano-structured cellulose films, this approach can be easily extended to other polysaccharides as well. The whole project aims at reducing organic solvents and to use mainly so-called eco-solvents.",Photopatterning of Cellulose Films for Creation of 2- and 3-Dimensional Nanostructures,FP7,31 August 2016,01 September 2013,75000.0 PHOTOQWELL,Imperial College London,health,"Concentrator photovoltaic solar systems achieve some of the highest module power conversion efficiencies and have the potential for clean electricity generation in the world's deserts and arid regions. Sunlight is collected by inexpensive optical collectors and focused upon small but highly efficient solar cells. Still, the costs of the overall system is high and further improvements must be done to enable the general implantation of this technology. This project will raise the efficiency of those highly efficient multi-junction solar cells by using nanotechnology to tailor the optical and electronic properties of the photovoltaic material. Key to the project is the design of internal optical modes in the solar cell, exploiting quantum effects, maximising absorption, reducing radiative loss and enabling the cells to become more tolerant to the changes in the solar spectrum that occur naturally during the day and season of the year.These designs will then be demonstrated in single and monolithic dual-junction prototype solar cells with the potential to break the present world record for a dual-junction solar cell of 31.7% and aiming to a 35% efficient devices.",Photonic optimisation of multiple quantum well structures for single and dual-junction solar cells,FP7,14 January 2015,15 January 2013,200371.0 PHOTORELEASE,Lille University of Science and Technology * Université de Lille 1 Sciences et Technologies (USTL),health,"The importance of carbon-based materials in biological applications has been recognized. Especially, nanodiamond particles (referred to as nanodiamonds, NDs) have started to emerge as novel candidate for promising applications in the field of nano-biotechnology as imaging probes and drug carriers. NDs do not show the toxicity of other nanoparticles, notably gold, making them ideal nanoscale drug delivery platforms. Furthermore, NDs can exhibit intrinsic fluorescence from point defects making them candidates for biomedical imaging applications. ND particles are particularly attractive for biomedical applications as functionalization and biomolecule immobilization are readily accomplished. Triggered drug release allows the functionalized NDs to find their targets before the drugs are activated by local conditions. In this sense, the NDs are performing the well established role of postdrugs, smuggeling the inactive compound to their targets where they are released through bond cleavage. The objective of the proposed program concerns the fabrication of NDs modified with photo-label linkers where different molecules can be directly attached, without chemically modification of the biomolecule itself. In a proof of principle, horse radish peroxidase (HRP) will be linked to NDs modified with the photo-label o-nitrobenzyl group and the release followed by UV/Vis. In a later state the controlled release of drugs such as ibuprofen, adriamycin or antigens will be looked at. The proposed research project brings together centers from France, the UK, Spain and the Ukrain. The network offers training in the fabrication and characterization of new materials for biological applications.",Fabrication of particles with photo receptors: bio-analytical application such as controlled drug delivery,FP7,31 August 2014,01 September 2011,186200.0 PHOTORODS,Consorzio CREO Centro Ricerche Elettro Ottiche,health,"Cadmium Telluride (CdTe) is already established as a prominent conventional solar cell semiconductor material due to its energy gap 1.5 eV with an almost perfect match to the solar spectrum. The aim of this research is to study the use of nano-structured CdTe as the absorbing layer in PV solar cells, and to evaluate the performance and industrial potential of these cells for a spread of PV applications, from low cost to high efficiency thermo-sensitive platforms and devices. It would require an investigation of processes for inexpensive fabrication of large periodic arrays of semiconductor nanostructures that will allow for (a) controlled variations in the size and composition of the nanostructures, (b) encapsulation of the semiconductor nanostructures in a rugged host material, (c) flexibility to use a variety of substrate materials, and (d) compatibility with standard silicon fabrication techniques. Additionally, the same CdTe-based PV nano-structures could be used as efficient imaging flat-panel direct-conversion semiconductor detectors for applications in such diverse fields as nuclear medicine, homeland security, astrophysics, and environmental remediation.",Photovoltaic cells based on nano-structured CdTe,FP7,02 May 2012,03 May 2010,229253.0 PHOTOSENS,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,health,"The PHOTOSENS project aims to develop a low-cost, mass-manufacturable, nano-structured, large-area multi-parameter sensor array using Photonic Crystal (PC) and enhanced Surface Enhanced Raman Scattering (SERS) methodologies for environmental and pharmaceutical applications. Integrating the PC and SERS based sensors with integrated optics coupling structures within a single sensor platform allows the implementation of a high-performance multi-parameter sensor. Currently, utilization of multi-parameter sensing is hindered by the lack of low-cost and, highly reproducibility fabrication methods for nano-structured surfaces. PHOTOSENS addresses these challenges by developing new roll-to-roll nanoimprinting manufacturing methods. Scientific work includes development of the multilayer nanophotonic sensor structure, nanoimprint materials for large-area fabrication, functionalized molecularly imprinted polymers (MIP) and high-volume manufacturing methods including Roll-to-Roll (R2R) nanoimprint processes for nano-texturing of large-area plastic films. PHOTOSENS will greatly increase understanding of photonic and plasmonic dispersion and field localisation effects in periodic nanostructures, such as Photonic Crystals, and their applicability to sensing purposes. PHOTOSENS demonstrates a multi-parameter large-area sensor platform for environmental and pharmaceutical sensing. The consortium is composed of 4 world-class research organisations, 2 SMEs and 3 large companies from 6 European countries representing the complete supply chain from technology developers to end users. The position of these organizations in their respective markets guarantees that the results of the project will be widely exploited providing the companies with a technological advantage over their global competitors and thus creating new high-tech jobs in Europe in this rapidly growing market.",Large Area Photonic Crystal Chemical Sensors,FP7,31 January 2014,01 February 2011,4900000.0 PHOTOSI,University of Bologna * Alma Mater Studiorum Università di Bologna,energy,"Silicon nanocrystals (SiNCs) have gained much attention in the last few years because of their remarkable optical and electronic properties, compared to bulk silicon. These unique properties are due to quantum confinement effects and are thus strongly dependent on the nanocrystal size, shape, surface functionalization and presence of defects. The aim of the present project is the coupling of SiNCs with photo- and electroactive molecules or multicomponent systems, like dendrons, to build up a new class of hybrid materials to be employed in the field of light-to-electrical energy conversion (solar cells). SiNCs possess several advantages with respect to more commonly employed, quantum dots, which usually contain toxic and rare metals like lead, cadmium, indium, selenium: a) silicon is abundant, easily available and essentially non toxic; b) silicon can form covalent bonds with carbon, thereby offering the possibility of integrating inorganic and organic components in a robust structure; c) absorption and emission can be tuned across the entire visible spectrum from a single material, upon changing the nanocrystal dimension. This project will address the understanding of the fundamental photophysical and electrochemical properties of SiNCs, and their electronic interactions with the functional coating units. Taking advantage of the acquired knowledge, the project will then be devoted to the implementation of these hybrid materials as light-harvesting and charge transport components in photoelectrochemical cells. PhotoSi is expected to lead to solar cells with high efficiency (superior electronic properties of the hybrid material), low cost (the amount of the nanostructured material is significantly reduced compared to conventional Si cells), and low environmental impact (Si is essentially non toxic, and new less-energy demanding synthetic methodologies will be explored).",Silicon nanocrystals coated by photoactive molecules: a new class of organic-inorganic hybrid materials for solar energy conversion,FP7,31 December 2016,01 January 2012,1182606.0 PHOTOSMART,Christian-Albrechts University of Kiel * Christian-Albrechts-Universität zu Kiel,photonics,"Smart surfaces with switchable properties hold great promise for future integrated sensors. Azobenzene molecules have been demonstrated to switch reversibly between the trans and cis isomer with picosecond time constants, when triggered with an external light source. Due to the different molecular geometries and electronic properties of the isomers, these may be used as molecular switches for realizing smart surfaces. The objective of this research proposal is to establish methods for integrating photo-switchable smart surfaces into miniaturized sensors. For efficient switching this requires on-chip light sources providing sufficient intensity at the location of the molecular switch. Ultraviolet and blue organic light emitting diodes will be integrated monolithically onto dielectric substrates with a periodically nanostructured high refractive index layer. This slab photonic crystal allows for resonant excitation of the molecular switches. Two types of smart surfaces will be studied. First, the reversible switching of wettability between hydrophilic and hydrophobic will be investigated, which is of particular importance for reconfigurable microfluidic chips. Second, the switchable surface adsorption of biomaterials is targeted. The periodic switching of the binding sites between an active and an inactive state will cause a periodic measurement signal. This allows for the use of lock-in techniques with superior signal-to-noise ratio and for subtraction of the background at same position. Combining both types of smart surfaces promises reconfigurable, multifunctional, highly-selective future integrated biosensors. The final goal of the proposed project is to demonstrate for the first time an integrated microsystem with smart surfaces switched by on-chip light sources for spatial and temporal control of the surface wettability as well as control of binding sites for biomolecules.",Photo-switching of smart surfaces for integrated biosensors,FP7,30 June 2018,01 July 2013,1499878.0 PHOTOSTM,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),environment,Understanding the mechanism of photo catalytic reactions is a key to systematically improve their efficiency and therewith enhance substantially the impact of green chemistry. Photo catalytic reactions are determined by the electronic level alignment between a catalyst and the reactant. This energy level alignment depends strongly on the local morphology of the catalyst and the absorption site of the reactant but is only poorly understood due to the difficulty to study photo catalytic reactions at the molecular length scale – the critical length scale for photo-catalytic processes.,Investigating Photo Catalytic Reactions at the Molecular Scale,FP7,05 July 2018,06 January 2013,0.0 PHOTOSURF,University College London,energy,"The PHOTOSURF project will investigate self-assembled networks of photo-sensitive molecules formed at semiconductor and dielectric surfaces. The interaction between light and photo-sensitive dye molecules adsorbed on semiconductors plays a pivotal role in several renewable energy technologies: dye sensitised solar cells (DSSC) and the photo-catalytic production of solar fuels. In both of these applications the configuration of dyes with respect to each other and the underlying surface is a key factor in determining how efficiently solar energy is converted to either electricity or to green fuel sources. Knowledge of how the nanoscale organisation of molecules influences the operation of solar energy devices, coupled with an increased ability to control that organisation, will help to maximise the efficiency of such devices. Self-assembly is a process by which individual molecules can organise themselves into ordered and complex structures through simple intermolecular interactions. In recent years the formation of ordered molecular networks on surfaces using 2D self-assembly has been an area of intense research. PHOTOSURF will use concepts from the field of 2D molecular self-assembly to control the structural arrangement of photo-sensitive dye and catalyst molecules on semiconductor and dielectric surfaces. These molecular structures will then be investigated using a range of techniques including scanning tunnelling microscopy (STM) and scanning microwave microscopy (SMM). Such experiments will allow the project to study charge transfer, photo-catalysis and light harvesting effects at the level of individual dye molecules. From these studies we will gain a deeper fundamental understanding of how molecular orientation, bonding and arrangement influences these physical and optical processes. This knowledge will be vital to the future development of cost effective solar energy technologies.",Investigating the 2D Self-Assembly of Photo-sensitive Molecules on Semiconductor and Insulating Surfaces,FP7,31 August 2017,01 September 2013,100000.0 PHOXY,Universiteit Utrecht * Utrecht University,manufacturing,"Phosphorus (P) is a key and often limiting nutrient for phytoplankton in the ocean. A strong positive feedback exists between marine P availability, primary production and ocean anoxia: increased production leads to ocean anoxia, which, in turn, decreases the burial efficiency of P in sediments and therefore increases the availability of P and production in the ocean. This feedback likely plays an important role in the present-day expansion of low-oxygen waters (“dead zonesâ€) in coastal systems worldwide. Moreover, it contributed to the development of global scale anoxia in ancient oceans. Critically, however, the responsible mechanisms for the changes in P burial in anoxic sediments are poorly understood because of the lack of chemical tools to directly characterize sediment P. I propose to develop new methods to quantify and reconstruct P dynamics in low-oxygen marine systems and the link with carbon cycling in Earth’s present and past. These methods are based on the novel application of state-of-the-art geochemical analysis techniques to determine the burial forms of mineral-P within their spatial context in modern sediments. The new analysis techniques include nano-scale secondary ion mass spectrometry (nanoSIMS), synchotron-based scanning transmission X-ray microscopy (STXM) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). I will use the knowledge obtained for modern sediments to interpret sediment records of P for periods of rapid and extreme climate change in Earth’s history. Using various biogeochemical models developed in my research group, I will elucidate and quantify the role of variations in the marine P cycle in the development of low-oxygen conditions and climate change. This information is crucial for our ability to predict the consequences of anthropogenically-enhanced inputs of nutrients to the oceans combined with global warming.","Phosphorus dynamics in low-oxygen marine systems: quantifying the nutrient-climate connection in Earth's past, present and future",FP7,12 July 2018,01 January 2012,1498000.0 PHYSBOIL,Universiteit Twente * Twente University,health,"Liquid-vapor phase transitions and boiling are omnipresent in science and technology, but, as far as basic understanding of the hydrodynamics, these phenomena remain 'terra incognita''. The objective of the proposed work is to achieve a fundamental understanding of the fluid dynamics and heat transfer of the liquid-vapor phase transition - in particular of boiling - both on a micro- and on a macro-scale, through experiments under well-defined and controlled conditions, accompanied by theoretical and numerical modeling. Up to now 'boiling'' has been nearly exclusively an engineering subject. We want to change this and make it a physics subject as we are convinced that boiling involves very interesting and practically relevant physics still in need of understanding. On the micro-scale the planned experiments include nucleation studies of individual and interacting vapor bubbles on superheated, geometrically and chemically micro- and nano-structured surfaces. In the bulk of the flow, nucleation will be achieved through laser heating, through local pressure gradients, and through acoustically triggered vaporization of metastable perfluorcarbon nanodroplets in a superheated liquid. The vapor bubbles will be monitored with ultra-high-speed digital imaging, micro particle velocimetry, infrared thermography, and heat flux measurements. On the theoretical side we will use molecular dynamics simulations and the level-set method. On the macro-scale the focus is on closed boiling turbulent flows, namely Rayleigh-Benard and Taylor-Couette flow. We will measure how the vapor bubble formation affects global quantities such as the heat flux and the angular momentum flux and thus the drag, and local flow properties such as the vapor bubble concentration. The numerical simulations, with one generic code for both geometries, will be based on discrete particle models.",Physics of liquid-vapor phase transition,FP7,29 February 2016,01 March 2011,2108000.0 PI-OXIDE,Universiteit Twente * Twente University,photonics,"In order to satisfy the future needs in telecommunication applications relevant to the community, e.g. METRO and Access networks, optical techniques will largely be employed. Since all kinds of passive and active functions might be required within one single photonic chip, concepts that allow for active / passive integration with low technological complexity, maybe even within the same processing step, are highly appreciated. This project aims at providing a novel technology for telecom applications that combines the advantages of the present technologies on the same chip. It proposes a radically new mass-fabrication technique of high-refractive-index, high-heat-conductivity, amorphous and crystalline oxide materials, which includes nano-localized active doping. It investigates a reliable parallel processing technology for high-quality nano-scale structures in these materials in order to produce functional nano-photonic devices based on Bragg gratings, ring resonators, power splitters, amplifiers and lasers for future use in optical access networks. It includes active functionality like light generation and amplification, still missing in today's Si-based technologies. This project is multidisciplinary, as it integrates the full range from optically active thin-film growth with the aim at mass production, the development of reliable parallel nano-structuring and nano-deposition processes, device fabrication, testing and simulation with the aim at integration of active and passive functionality on the same chip and partly within a single processing step. This project possesses the clear perspective of novel future applications especially in the telecom market. A consortium with 4 academic and 2 industrial partners from 4 European countries, all with extensive experience and international recognition but complementary skills and tasks in the project, will realize this program.",Photonic integrated devices in activated amorphous and crystalline oxides,FP6,30 November 2008,30 August 2005,1853392.0 PICMOS,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"For future generation electronic circuits a severe bottleneck is expected on the global interconnect level. One of the most promising solutions is the use of an optical interconnect layer. Therefore, PICMOS will demonstrate the feasibility of adding a photonic interconnect layer on top of silicon ICs. This interconnect layer will be fabricated by a combination of wafer bonding and wafer-scale processing steps. It will be planar and will be built from a high-density passive optical wiring circuit integrated with InP-based sources and detectors using a wafer bonding approach. Two different integration strategies will be investigated: a wafer-to-wafer bond technology where the photonic interconnect layer is fabricated in parallel with the electronic circuits wafer and where both wafers are subsequently bonded together and an above-IC approach where the interconnect layer is fabricated directly on top of the electronic circuits. For the first approach, SOI-waveguides allowing for very high-density wiring will be developed. For the above-IC approach, an innovative type of high-contrast polymer waveguides compatible with CMOS back-end processing will be developed. Both types of waveguides will be fabricated using standard CMOS-processing techniques. The III-V epi material for the active photonic devices will be bonded on top of the waveguide circuits and the substrate will be removed. The active devices will be defined in the remaining membrane. In all fabrication steps, only waferscale technologies will be employed with the only exception made for the bonding of the III-V semiconductor material. Because of the large size difference between silicon and InP wafers and the limited space occupied by the active photonic devices, a rapid die-to-wafer bonding step will be developed for this step. In parallel with the technological oriented work, system studies will define application domains for PICMOS and generic parameter specifications for all subcomponents.",Photonic Interconnect Layer on CMOS by Wafer-Scale Integration,FP6,31 March 2007,31 December 2003,2497000.0 PICNQO,Technische Universiteit Delft * Delft University of Technology,photonics,"Since their discovery in 1991, single walled carbon nanotubes (SWNTs) have led to a worldwide explosion of research activities due to their outstanding electrical properties. Ten years later, the demonstration of optical emission from semiconducting SWNTs has opened a new field for nano-optics. In terms of quantum information processing, it has been recently shown that SWNTs are promising candidates for single spin quantum computing. Combined with their promising optical properties, this naturally promotes SWNTs as an ideal system to fulfil a crucial goal in quantum information processing, i.e. to link solid state qubits used for information processing (single spins) with flying qubits used for transmitting quantum information (photons). Schemes aiming at manipulating spins in semiconducting nanotubes all-optically, and more general applications of quantum optics necessitate the ability to confine electrons and holes (excitons) in a small recombination region called an optical quantum dot. One significant disadvantage of SWNTs with respect to optics is that, unlike in epitaxially grown semiconducting heterostructures, there is no obvious way to controllably confine excitons. In the proposed project, I will engineer and control an optically active quantum dot in an ultraclean suspended nanotube by means of an innovative approach aiming at exploiting the nanotube many-body interactions, and study its far-field optical properties. In a second step, I will study the coupling of the defined quantum dot to surface plasmons via metallic nanowire guides. This will constitute an important step towards future buses for transferring quantum information at the nanoscale through on chip flying qubits. These two experiments will be realised in a new type of devices recently developed in the Quantum Transport group at TU Delft, using a new technology combining a set of local electrical gates acting on single ultraclean suspended nanotubes.",A Plasmonic Interface to Carbon Nanotube Quantum Optics,FP7,30 September 2011,01 March 2010,161248.0 PICSEN,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),photonics,"This project concerns the field of coherent, nonlinear, ultrafast light-matter interaction on a quantum level in solids. It proposes to experimentally explore limits of: i) internal coherence of an individual emitter; ii) radiative coupling between pairs of emitters. A potential long term application of this work could be envisaged, as one can expect that individual emitters could serve as qubits for implementations of optically controlled quantum information processing in solids. As individual emitters we will employ excitons in semiconductors: either bound to impurities or confined in quantum dots. Firstly, by embedding the latter into upright photonic nanowires, that are now available in the team, we will amplify the collection of their coherent optical response by nearly four orders of magnitude as compared to the current state-of-art. This will provide an unprecedented access to their coherent as well as dephasing interaction with phonons. It will also enable retrieval of their n-wave mixing responses to scrutinize coherent couplings within an individual emitter. The second objective is the demonstration of an efficient, controllable and non-local coherent coupling mechanism between distant emitters, which is a prerequisite for the construction of quantum logic gates and networks. Here, such a radiative coupling will be demonstrated and manipulated using resonant emitters embedded into in-plane one-dimensional waveguides, which permit virtually unattenuated propagation of coherence. The internal and propagative coherence of individuals and radiatively coupled pairs will be explored using beyond-the-state-of-the-art methods of coherent nonlinear spectroscopy. Specifically, we will develop a spatially-resolved heterodyne spectral interferometry combined with ultrafast pulse-shaping. The proposed advanced methodology of this ERC project can be associated with techniques developed in other domains, like nuclear magnetic resonance and astrophysics instrumentation.",Propagative and Internal Coherence in Semiconductor Nanostructures,FP7,30 November 2017,01 December 2012,1499708.0 PIEZOSCAFF,National University of Ireland Galway,health,"Bone tissue regeneration remains an important challenge in the field of orthopaedic and craniofacial surgery and sees a transplantation frequency second to that of blood. The total number of bone graft surgeries performed each year worldwide to repair bone defects in orthopaedics and dentistry is more than 2.2 million. Current clinical treatments for critical-size defects are challenging, and despite the natural capacity of bone for healing, if an injury is beyond a critical limit (critical size defect), it cannot heal by regeneration. Bone grafting is the current standard treatment; however, given the inherent limitations of this approach, bone tissue engineering and advanced biomaterials that mimic the structure and function of native tissues hold potential as a promising alternative strategy. Nanocomposites containing hydroxyapatite have attracted attention as they are structurally similar to natural bone and provide an osteoconductive matrix to which bone can react with 'bone'. However, nanocomposites do very little to assist in the recruitment of host cells to assist in bone repair. To circumnavigate this issue, we propose the incorporation of piezoelectric nanofibres to promote guided cellular infiltration. At sites of bone fracture, naturally-occurring electric fields exist during healing which promote cell migration and may become perturbed at sites of critical bone defects. Our aim is to develop a novel hybrid material that consists of a biodegradable bioactive hydrogel network containing hydroxyapatite nanoparticles and PVDF(TrFE) nanofibres to produce a scaffold with mechanical and electrical properties akin to bone. In this study, the hybrid material will be fully characterised pertaining to its morphology, chemical composition, mechanical stability and piezoelectric response. Cells will be encapsulated within the hybrid material and viability and cytoperformance studies conducted as well as assessment of the materials innate osteoconductive properties.",Piezoelectric nanohybrid scaffolds for bone regeneration,FP7,30 September 2015,01 October 2013,50000.0 PILOTMANU,MBN Nanomaterialia SpA,energy,"The vision of PilotManu is the upscale of the current mechanical alloying technological facility into a powder manufacturing pilot line by further developing existing IPR-covered results owned by the SMEs in the consortium related to mechanical alloying technology and to innovative powder materials for different applications. The baseline technology that will be upscaled from a technological facility status into pilot scale, is the High Energy Ball Milling machine, able to deliver innovative materials for new product lines developed by SMEs and industrial partnership that will lead the technological upscale. The project will demonstrate the technological and economical viability of the pilot line by implementing advanced materials into coatings, abrasive tool and additive manufacturing applications. Additional application sectors will be represented in the business cases by analyzing the cost/benefits of using the following new materials: Mg hydrides for hydrogen storage, thermoelectrics for energy harvesting, flame retardant textile and polymer nanocomposite for rapid prototyping. The potential impact brought by the new HEBM pilot production will be transversal also in all those technological sectors demanding high performance and outstanding material properties not achievable by conventional products. These huge un-exploited knowledge reservoir related to materials produced via HEBM or Mechanical Alloying will be unlocked by the Pilot Manu production system able to bring these results into the market.",Pilot manufacturing line for production of highly innovative materials,FP7,30 September 2017,01 October 2013,4014465.0 PINP,University of Verona * Università degli Studi di Verona,health,"The development of assays based on molecular recognition for measuring biomarkers is a critical task for the diagnosis and prognosis of pathologies. The present project aims at developing synthetic nanoparticles (NP) for the quantification of the peptide biomarker hepcidin (hep) which regulates iron homeostasis. A modern strategies for mimicking receptors consists of NPs produced by molecularly imprinted polymer (MIP) technology. MIPs are prepared by a template-assisted emulsion polymerization. After removal of the template, complementary cavities are exposed in the polymer. The target biomarker, hep, is a 25-residue peptide (hep25) present in urine and plasma, other N-terminus truncated isoforms such as hep20 and hep22 were also found in humans. It is known that the first 5 amino acids of the N-terminus of hep25 are essential for iron homeostasis while the role of other isoforms is still unclear. Given that the imprinting is more successful for short peptides only 2 crucial portions of the full length peptide are synthesized as templates which are also functionalized to impose a direction of imprinting. The precision of the template synthesis ensures a higher fidelity of imprinting during the NPs synthesis improving the molecular recognition. The goal of the project consist in designing an assay for the determination of serum and/or urinary hep, based on MIPs selective for hep isoforms and arranged in a pseudo-immuno assay format, further extended in sensitivity by the addition of fluorescent tags. At last, an evaluation of the assay with clinical sample is planned to be performed. The possibility of using nano-sized MIPs as plastic antibodies in ELISA-like assays has the obvious advantage of a potential widespread diffusion. The proposed ELISA-like assay with fluorescent tags is very innovative and have the potential versatility to be transposed to different applications. Moreover the deep impact of the outcomes allow the access to the diagnostic market.",Synthesis of peptide imprinted nanoparticles and their integration to ELISA-like assay for the quantification of hepcidin,FP7,30 April 2015,01 May 2013,179739.0 PINSYS,University of Leeds,health,"This project will develop novel, bio-inspired routes to the synthesis of porous inorganic nanoparticles with sponge-like internal structures, using nanostructured polymer capsules as templates. The application of these structures in targeted drug delivery and controlled release will then be investigated. Biominerals provide a unique inspiration for the design and synthesis of new materials. While showing remarkable structures and properties, these amazing materials form in aqueous environments under ambient conditions and organic molecules -either as soluble additives or insoluble matrices -are used to control crystal growth. We will here employ a bio-inspired strategy to generate porous calcium carbonate and calcium phosphate nanoparticles with sponge-like structures. A novel class of polymer capsules with bicontinuous internal structures, which are formed by the self-assembly of comb-like block copolymers in water will be used as templates. This system will also provide a unique opportunity for studying the effect of confinement on crystal nucleation and growth. Crystallisation in confinement is widespread in Nature, the environment and technology, and the research will therefore impact on fundamental research and technology across many disciplines. The synthesised porous nanoparticles will then be used to build targeted drug delivery systems (DDSs) by encapsulating anti-cancer drugs for the treatment of bone cancer. While mesoporous silica nanoparticles have been investigated quite extensively, little work has to-date been performed on alternative nanoporous crystalline inorganic nanoparticles. As compared with mesoporous silica, the calcium phosphate and calcium carbonate nanoparticles will show superior biocompatibility and biodegradation, and will also offer acid-responsive solubility and therefore will give the pH-responsive release of the encapsulated drugs from the drug delivery system in the acidic environment of tumors.",Bio-Inspired Approaches to Porous Inorganic Nanoparticles and Their Application as Targeted Drug Delivery Systems,FP7,02 September 2014,03 September 2012,209033.0 PISA,University of Sheffield,health,"The efficient, reproducible synthesis of bespoke organic nanoparticles of controlled size, morphology and surface functionality in concentrated solution is widely regarded to be a formidable technical challenge. However, recent advances by the Principal Investigator (PI) suggest that this important problem can be addressed by polymerisation-induced self-assembly (PISA) directly in aqueous solution to form a range of diblock copolymer 'nano-objects'. The proposal combines three synergistic themes within the PI's group: (i) controlled-structure water-soluble polymers, (ii) living radical polymerisation and (iii) novel polymer colloids. More specifically, the PI will work closely with four post-doctoral scientists and a PhD student to design a series of diblock copolymer nanoparticles with either spherical, worm-like or vesicular morphologies under dispersion polymerisation conditions in either water, alcohol or n-alkanes. This exciting and timely fundamental research programme will produce world-leading scientific innovation. Moreover, the targeted nanoparticles will be evaluated for various potential applications, such as (i) intracellular delivery of various biomolecules (e.g. DNA, proteins, antibodies), (ii) readily sterilisable biocompatible hydrogels, (iii) bespoke Pickering emulsiifiers and foam stabilisers, (iv) tough nanocomposite monoliths, (v) new components for next-generation paints, (vi) novel boundary lubricants for high performance engine oils. Informal collaborations with four academic partners and four industrial companies will ensure that maximum scientific value and economic impact is extracted from this ambitious work programme. All research findings will be published in top-quality scientific journals and the PI will provide appropriate mentoring to inspire his research team to become the next generation of creative, productive scientists for the EC.",Polymerisation-induced self-assembly,FP7,31 January 2018,01 February 2013,2480300.0 PIXIE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"This proposal is dedicated to hybrid systems combining High-Tc superconductors (HTCS) with (oxide or not) ferromagnets (FM). This project aims at experimentally underpinning the microscopic mechanisms of interaction between HTCS and FM. Our goals are to understand how the d-wave superconductivity of HTCS diffuses into a FM material (in particular to determine if new quantum states such as spin-triplet pairing emerge in the FM), and to characterize spin-polarized quasiparticle transport across HTCS/FM interfaces (to measure the spin diffusion length, and to determine the mechanisms of spin relaxation in HTCS). These objectives are key to understand novel behaviours observed in HCTS/FM hybrids. Aside from the fundamental interest of these issues, the possibility of coupling HTCS across FMs over long distances, and the way the phase of the superconducting wave function evolves as it travels through it, are relevant in view of the realization of HTCS magnetic Josephson junctions and related devices. On the other hand, learning about the effects of spin accumulation and the mechanism of spin diffusion in HTCS may allow enhancing 'superconducting spin-switch' effects and help engineering novel magnetoresistive devices based on spin dependent transport in HTCS. This project will be developed at the hosting institution, the Unité Mixte de Physique CNRS/Thales which provides with an ideal environment, owing to the gathering of expertises available: know-how on the growth of oxide heterostructures, state-of-art nanolithography and cutting-edge close-field microscopy techniques.",Spin triplet proximity effect and spin-injection in High Tc superconductor/ferromagnetic hybrids,FP7,30 April 2013,01 May 2011,186248.0 PLACES2BE,STMicroelectronics (Crolles 2) SAS,information and communications technology,"Objectives: The general goal of this project is the industrialization of 28/20nm Fully Depleted (FD) Silicon On Insulator (SOI) Technology platforms, enabling 2 different sources in 2 different European countries. The project also aims at establishing and reinforcing a design ecosystem in Europe using these platforms. Last, the project considers extremely important to explore extension towards FD devices at 14/10nm, in order to continue the road toward more efficient technologies.","Pilot Lines for Advanced CMOS EmbodimentS in 2x nodes, Built in Europe",FP7,12 July 2017,12 March 2012,0.0 PLACQED,University of Cambridge,health,"This proposal aims to realize physical systems for the realization of plasmonic cavity quantum electrodynamics using optically active diamond-based quantum systems such as atomic impurities. Color centers in diamond provide a suitable test bed for applications of quantum information processing, as well as selected spin-spin interactions. While there are hundreds of known color centers in diamond, but only one (Nitrogen vacancy) is studied extensively. We will study optical properties and identify energy levels of alternative color centers both naturally occurring and artificially implanted, potential candidates being Ni, Si, or Fe impurities. We will in parallel study solid-state-based cavity QED with light confinement at sub-wavelength scale. Using metal nanostructures and plasmons, we aim at achieving individual or ensemble strongly coupled emitter-cavity systems. Further, we will study how sub-wavelength structures of a medium alter the material-based properties, so the optical fields can experience exotic media with negative refractive indices.",Plasmonic cavity quantum electrodynamics with diamond-based quantum systems,FP7,31 July 2013,01 August 2008,1712342.0 PLAISIR,Centre Suisse d'Electronique et de Microtechnique (CSEM) - Recherche et Developpement,photonics,"The aim of this project is to transfer the latest advances in plasmonics achieved in the visible to the mid-IR. The main objectives of the project are (1) to look at the fundamental limits and develop new simulation tools for plasmons in the mid-IR, (2) to develop plasmon enhanced surfaces for spectroscopic chemical sensing (SCS), and (3) to use plasmon enhanced surfaces for light harvesting technology. The result of the project will include new software, SCS surfaces for infra-red spectroscopy and smart, cheaper, mid-IR photodetectors. The term plasmonics refers to the investigation, development and application of enhanced electromagnetic properties of metallic (nano-) structures and is starting to find applications in a range of photonic devices such as VCSELs and high speed photodetectors. While the promise of plasmonics photonic components in the visible and NIR is very promising, this project will exploit the huge potential for plasmonics in the IR (i.e. the 1.6-16 µm range) that could be truly disruptive. In the mid-IR (a) plasmon losses are much lower than in the visible so the range of possible devices is much larger (b) this area is largely unexplored for applied plasmonics, and (c) IR technology is undergoing a quiet revolution due to key advances such as such room temperature Quantum Cascade Lasers and miniature Fourier transform spectrometers (FTS). This project will help launch the IR revolution by enabling both SCS surfaces and better mid-IR detectors. PLAISIR will develop SCS with sensitivity more than 200 times larger than that of a simple surface. This will be combined with microfluidics and integrated into a FTS. The project will work with both InGaAs and HgCdTe photodetectors, by using LHT to improve their noise performance, and tailor their spectral and polarization response. This project includes 4 major actors in fundamental and applied plasmon research, 3 SMEs and an external advisory board made up of strategic end users and key academics",PLAsmonic Innovative Sensing in the IR,FP7,31 December 2012,01 January 2010,2850000.0 PLAQNAP,University of Southern Denmark * Syddansk Universitet,photonics,"Plasmon-based nanophotnics, an explosively growing research field concerned with surface-plasmon waveguides and circuitry, is oriented towards exploiting unique perspectives opened for radiation guiding along metal surfaces: extreme mode confinement (i.e., far beyond the diffraction limit) and seamless interfacing of electronic and photonic circuits (that both utilize the same metal circuitry). At the same time, unavoidable radiation absorption by metals results in the fundamental trade-off between the mode confinement and propagation loss, so that the problem of making the most of the above unique features becomes of paramount importance. The proposal encompasses two ground-breaking research directions in plasmonics that explore and utilize extremely confined plasmon-waveguide modes for functional and quantum nanophotonics. These directions of in-depth investigations concentrate within two interrelated and largely unexplored research areas within plasmonics: development of ultra-compact plasmonic configurations exhibiting unique functionalities and realization of strong coupling between extremely confined plasmonic modes and individual quantum emitters. Fundamental studies of ultimate mode confinement and coupling to quantum emitters would evolve into investigations carried out within forefront topics including (i) dynamic control of plasmon-waveguide modes using the same metal circuitry for both radiation guiding and its control with electrical signals; (ii) moulding the radiation flow by gradually varying waveguide cross sections in order to realize efficient nanofocusing of radiation, miniature ultra-dispersive wavelength-selective components and table-top models of plasmonic black holes, and (iii) quantum plasmonics with individual quantum emitters being strongly coupled to deep subwavelength surface plasmon modes, targeting the realization of a saturable waveguide mirror, single-photon transistor and long-distance entanglement of two remote quantum emitters.",Plasmon-based Functional and Quantum Nanophotonics,FP7,31 January 2019,01 February 2014,2278636.0 PLASBIORES,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The objective of this project is to study the confinement of light in nanometric apertures in a metal film, the change of the transmission properties for very small changes in the refractive index inside the holes, and the subsequent development and fabrication of a device that serves to visualize singe DNA molecules, stretched in a channel and assembled into the nanohles, withouth fluorescent markers. For this, during the first stage (2 years in Berkeley), the fellow will study theoretically the system, will fabricate the devices, and study the transmission of light trhough single nanometric holes using the capabilities of the host group for optical characterization of nanostructures. Then, the sensitivity to the presence of DNA will be evaluated, by measuring the changes after specific hybridization inside the holes. The introduction of single nanoparticles (fluorescent or metallic) in the holes will be studied. During the reintegration stage (1 year in Copenhagen), the fellow will integrate the structures as part of a micro/nano fluidic device, for stretching and assembling of DNA single molecules into the pits, and develope the methodology to measure the change in the transmission trough the holes (when filled) to enable lable free visualization of the strands.",Plasmonic Biosensors based on nanometric optical Resonators integrated with point-light-sources for label free detection of DNA,FP7,01 June 2015,06 October 2010,245865.0 PLASM-ON-FIBRE,CAS - HEFEI INSTITUTES OF PHYSICAL SCIENCE (CASHIPS),photonics,"The proposed knowledge transfer project on Advanced plasmonic-on-fibre devices for optical communication and sensing applications (Plasm-on-fibre) via this International Incoming Fellowship (IIF) programme will transfer the knowledge and expertise of the Marie Curie IIF Fellow Dr J Zhang from the Institute of Solid State Physics (ISSP) of Chinese Academy of Sciences, who is specialised in plasmonics and nanophotonics, to the EU host -Aston Institute of Photonic Technologies (AIPT) at Aston University in the UK to carry out the world-class research in the new emerging science area -Plasmonics. Working in the defined four key research objective areas: R1: In-depth theoretical study and advanced fabrication of novel fibre gratings for efficient excitation of surface plasmon polaritons; R2: Exploring nanomaterials and nanostructures for novel plasmonic functions; R3: Developing ultrafast magneto-plasmonic modulation function and devices based on novel hybrid multi-layer excitation of surface plasmon polaritons; R4: Developing next generation plasmonic-on-fibre biosensors based on hybrid fibre gratings and plasmonic nanostructures, we anticipate this project will generate new knowledge, explore potential functions and develop novel plasmonic-on-fibre devices for optical communication and sensing applications and lead to long term collaboration between AIPT and ISSP. In parallel, this IIF project will also aim to train Post-docs and Ph.D and Master students at AIPT and form a network with 4 academic and 3 industrial partners in Europe. The outcome of this project will enhance the EU leading position in fundamental knowledge, new ideas and novel devices and technologies in modern plasmonics.",Advanced plasmonic-on-fibre devices for optical communication and sensing applications,FP7,,,15000.0 PLASM-ON-FIBRE,Aston University,photonics,"The proposed knowledge transfer project on Advanced plasmonic-on-fibre devices for optical communication and sensing applications (Plasm-on-fibre) via this International Incoming Fellowship (IIF) programme will transfer the knowledge and expertise of the Marie Curie IIF Fellow Dr J Zhang from the Institute of Solid State Physics (ISSP) of Chinese Academy of Sciences, who is specialised in plasmonics and nanophotonics, to the EU host -Aston Institute of Photonic Technologies (AIPT) at Aston University in the UK to carry out the world-class research in the new emerging science area -Plasmonics. Working in the defined four key research objective areas: R1: In-depth theoretical study and advanced fabrication of novel fibre gratings for efficient excitation of surface plasmon polaritons; R2: Exploring nanomaterials and nanostructures for novel plasmonic functions; R3: Developing ultrafast magneto-plasmonic modulation function and devices based on novel hybrid multi-layer excitation of surface plasmon polaritons; R4: Developing next generation plasmonic-on-fibre biosensors based on hybrid fibre gratings and plasmonic nanostructures, we anticipate this project will generate new knowledge, explore potential functions and develop novel plasmonic-on-fibre devices for optical communication and sensing applications and lead to long term collaboration between AIPT and ISSP. In parallel, this IIF project will also aim to train Post-docs and Ph.D and Master students at AIPT and form a network with 4 academic and 3 industrial partners in Europe. The outcome of this project will enhance the EU leading position in fundamental knowledge, new ideas and novel devices and technologies in modern plasmonics.",Advanced plasmonic-on-fibre devices for optical communication and sensing applications,FP7,,,231283.0 PLASMANANOSMART,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"The project is aimed at investigation of the novel routes to prepare functional 2D-substrates or 3D-scaffolds with artificial cell-instructive niches for cardiovascular and bone implants using sophisticated plasma- and electron beam-assisted nanofabrication technologies. The project's grand challenges are as follows: 1) Plasma-assisted fabrication of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds of polymers, titanium and shape-memory alloys to control the differentiation of MSCs towards osteogenic and vascular (endothelial) lineages 2) Deterministic nanofabrication of the endothelial cell-targeted surface chemistry, topography and charge of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds for the prevention of thrombosis of polymers, titanium and shape-memory alloys-based materials 3) Control over the hydrophobic nitric oxide groups containing surface chemistry, wettability and charge that prevent the formation of biofilm and adhesion of platelets 4) Differential diagnostics of cell associations and bioengineering constructions in vitro by use of synchrotron radiation 5) The development and studying of the novel 2D-substrates and 3D polymer scaffolds and their behavior in a bio-reactor (via tissue engineering) in vitro by use of dedicated X-ray multiple contrast diagnostics (objective for re-integration phase of the project). Completing the research planned during the PlasmaNanoSmart project it is suggested to obtain new fundamental data on biological response of novel elaborated biocomposites, which will serve further breakthrough in the field of 3D-bioscaffold technologies for regenerative medicine. The 'cell biochips' advanced technology for 'smart implants' carrying artificial niches for MSCs will be developed which allows us to gradually replace bioinert and bioactive materials. This new bioengineering (biomimetical) approach will reduce the medical, social and economic risks for the public (compared to cell therapy).",Plasma- and electron beam-assisted nanofabrication of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds with artificial cell-instructive niches for vascular and bone implants,FP7,30 June 2015,01 July 2013,168794.0 PLASMANANOSMART,Tomsk Polytechnic University,health,"The project is aimed at investigation of the novel routes to prepare functional 2D-substrates or 3D-scaffolds with artificial cell-instructive niches for cardiovascular and bone implants using sophisticated plasma- and electron beam-assisted nanofabrication technologies. The project's grand challenges are as follows: 1) Plasma-assisted fabrication of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds of polymers, titanium and shape-memory alloys to control the differentiation of MSCs towards osteogenic and vascular (endothelial) lineages 2) Deterministic nanofabrication of the endothelial cell-targeted surface chemistry, topography and charge of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds for the prevention of thrombosis of polymers, titanium and shape-memory alloys-based materials 3) Control over the hydrophobic nitric oxide groups containing surface chemistry, wettability and charge that prevent the formation of biofilm and adhesion of platelets 4) Differential diagnostics of cell associations and bioengineering constructions in vitro by use of synchrotron radiation 5) The development and studying of the novel 2D-substrates and 3D polymer scaffolds and their behavior in a bio-reactor (via tissue engineering) in vitro by use of dedicated X-ray multiple contrast diagnostics (objective for re-integration phase of the project). Completing the research planned during the PlasmaNanoSmart project it is suggested to obtain new fundamental data on biological response of novel elaborated biocomposites, which will serve further breakthrough in the field of 3D-bioscaffold technologies for regenerative medicine. The 'cell biochips' advanced technology for 'smart implants' carrying artificial niches for MSCs will be developed which allows us to gradually replace bioinert and bioactive materials. This new bioengineering (biomimetical) approach will reduce the medical, social and economic risks for the public (compared to cell therapy).",Plasma- and electron beam-assisted nanofabrication of two-dimensional (2D) substrates and three-dimensional (3D) scaffolds with artificial cell-instructive niches for vascular and bone implants,FP7,,,15000.0 PLASMANICE,TUT Foundation - Tampere University of Technology * TTY-Säätiö - Tampereen Teknillinen Yliopisto,manufacturing,"Atmospheric plasma techniques as processing methods have a number of advantages which include their ability to tailor the surface chemistry at the nanometre level. As such, the plasma treatments are energy efficient, reproducible and environmentally clean. In-line, continuous reel-to-reel processing equipment has been developed in the last 5 years. The wide scale application of this nano-processing technology in the pre-treatment of packaging materials in reel-to-reel processing has however been severely limited. One of the main reasons for this is the relatively slow processing velocity for coating depositions. In general, the velocities need to be increased by 2-5 fold in order to fully exploit the new nano-processing techniques. This proposal will address these issues in order to assist in the transfer of atmospheric plasma processing technology from the laboratory scale to industrial level in the packaging industry. Special attention will go out to the very promising combination with sol-gel technology. A method and equipment for in-line plasma deposition of high-barrier bio-based coatings to be applied in conjunction with extrusion coating at industrial line speeds will be developed. The approach will exploit sol-gel coatings applied on the substrates by plasma deposition. The substrates include paper, cardboard and plastic films. Renewable, biobased and biodegradable materials will be used as extrusion coatings. The project aims at replacement of fluoropolymer based grease barrier materials with sol-gel coated bioplastics and substitution of non-renewable barrier packaging films with renewables based materials in general. To achive these objectives, several leading European institutes and universities in atmospheric plasma deposition technology (VITO and TUE), sol-gel development (FhG-ISC and VTT) and extrusion coating and analytics development (TUT and JSI) together with a range of industrial participants are incorporated in the proposal.",Atmospheric Plasmas for Nanoscale Industrial Surface Processing,FP7,09 June 2014,10 January 2008,4361650.0 PLASMAQUO,University of Vigo * Universidade de Vigo,photonics,"This proposal aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determination of the interaction mechanisms between mixed colonies and their manipulation through external parameters. This will involve a first stage related to the careful design of the most appropriate nanoparticle morphology and composition, as well as an understanding of their specific assembly processes (both on substrates and in solution), so that the collective plasmonic response will be optimized towards the enhancement of the Raman signal of the probe molecular codes. Coating of the nanoparticle supercrystals with a mesoporous layer will be required to protect them against contact with bacteria and cells, while permitting contact with the QS signaling molecules. Ultimately, when the sensing system has been optimized and its performance demonstrated for monitoring of QS signals and colony growth, two final and important goals will be pursued. First, the interaction between mixed colonies (bacteria-bacteria and bacteria-eukaryotic cell) will be monitored in order to get information about synergic or antagonist (toxicity) QS mechanisms during the growth and proliferation of different bacteria and interspecies. This goal will permit the design of in vitro experiments where a bacterial strain may be manipulated by means of external introduction of the appropriate QS signaling molecules. Finally, the major challenge will be the practical demonstration of the ability of these new materials in this particular configuration for understanding and manipulating the growth and communication of different types of prokaryotic and peukaryotic cells.",Development of plasmonic quorum sensors for understanding bacterial-eukaryotic cell relations,FP7,29 February 2016,01 March 2011,2247629.0 PLASMATS,Ghent University * Universiteit Gent,health,"In this project, I will explore the unique combination of two fascinating research themes: electrospinning and plasma technology. Electrospun nanofibrous matrices (so-called mats) are an exciting class of materials with a wide range of possible applications. Nevertheless, the development and functionalization of these electrospun materials remain very challenging tasks. Atmospheric pressure plasma technology will be utilized by my research group to create advanced biodegradable electrospun mats with unprecedented functionality and performance. To realise such a major breakthrough, plasma technology will be implemented in different steps of the manufacturing process: pre-electrospinning and post-electrospinning. My group will focus on four cornerstone research lines, which have been carefully chosen so that all critical issues one could encounter in creating advanced biodegradable electrospun mats are tackled. Research cornerstone A aims to develop biodegradable electrospun mats with appropriate bulk properties, while in research cornerstone B pre-electrospinning polymer solutions will be exposed to non-thermal atmospheric plasmas. This will be realized by probing unexplored concepts such as discharges created inside polymer solutions. In a third cornerstone C, an in-depth study of the interactions between an atmospheric pressure plasma and an electrospun mat will be carried out. Finally, the last cornerstone D will focus on plasma-assisted surface modification of biodegradable electrospun mats for tissue engineering purposes. Realization of these four cornerstones would result in a major breakthrough in their specific field which makes this proposal inherently a relatively high risk/very high gain proposal. I therefore strongly believe that this research program will open a whole new window of opportunities for electrospun materials with a large impact on science and society.",Plasma-assisted development and functionalization of electrospun mats for tissue engineering purposes,FP7,31 January 2019,01 February 2014,1391100.0 PLASMENTA,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"The field of quantum plasmonics has emerged as a combination of quantum optics and plasmonics with the promise of allowing nanoscale quantum circuits and communication. To achieve this goal fundamental knowledge of plasmon on the quantum scale is required but missing up to now. This project presents a first step by employing a novel approach to measure the interaction of entangled surface plasmon polaritons by nanoscale all-plasmonic detector. To achieve this goal, we will create a conceptually new plasmon detector consisting of star-shaped nanoparticles placed close to a gold surface. The detection mechanism is relies on the highly efficient up-conversion of surface plasmon polaritons mediated by the gold nanostars into higher energy photons. The created detector will be used to measure two single plasmons generated by single photons. The demonstrated single plasmon efficiency will allow us to explore the interaction of two entangled surface plasmon polaritons. From this research we hope to gain further insight into the quantum nature of surface plasmon polaritons and their interaction on the nanoscale.",Nanoscale detection of entangled surface plasmon polaritons,FP7,30 June 2012,01 April 2011,109988.0 PLASMETA,NWO - FOUNDATION FOR FUNDAMENTAL RESEARCH ON MATTER (FOM),energy,"IIn this program I will demonstrate control of light at length scales well below the free-space wavelength, leading to entirely new fundamental phenomena and important applications. The research program is built on specially engineered metamaterials composed of metal nanostructures that support surface plasmons that are embedded in a dielectric. The program is composed of three strongly related topics: 1) I will experimentally demonstrate an entirely new class of optical metamaterials that posses a refractive index that can be tuned over a very large range: -10 < n < +10. Based on coupled plasmonic waveguides, these materials will, for the first time, show true left-handed behaviour of light (n < 0) in the UV/blue spectral range. I will demonstrate negative refraction of light and use these materials to demonstrate the 'perfect lens' which enables sub-wavelength imaging of (biological) nanostructures. 2) I will use plasmonic metamaterials to engineer the flow of light in thin-film solar cells. By controlling the scattering and trapping of light using plasmonic nanostructures integrated with semiconductor waveguide slabs I will demonstrate ultra-thin solar cells with efficient collection and conversion of infrared light, aiming at beating the ergodic light trapping limit. 3) I will demonstrate strong coupling between light and mechanical motion in the smallest possible volume. Light trapped in plasmonic metamaterials exerts a force that can lead to a shift in the plasmonic resonance frequency which in turn provides feedback on the mechanical motion. We will use this nanoscale coupling mechanism to actively cool and heat mechanical motion in plasmonic nanostructures and use this phenomenon in a new type of plasmon-based quartz oscillator.",Plasmonic Metamaterials,FP7,30 June 2016,01 July 2011,2286000.0 PLASMHACAT,University of Leuven * Katholieke Universiteit Leuven,energy,"Many critical photochemical and photophysical processes, from photosynthesis in plants, to photocatalytic reactions, and to generation of electricity in solar cells, depend on an efficient light-matter interaction. In order to increase, for example, the efficiency of photocatalysis, the interaction of the photocatalyst with light has to be increased. This project will pursue two lines of investigation in order to achieve this. Firstly, the concept of light-harvesting will be exploited. Light energy can be harvested by collecting, directing and concentrating it at a reaction center, in a fashion that mimics that used by plants. Secondly, for specific types of catalysis such as noble metal nano-particle (NP) based catalysis, the plasmon light field at the metal NPs can potentially be used to enable a more efficient light-matter interaction. The applicant proposes to combine both approaches, to create a plasmonic antenna to funnel light to a reaction center, whilst at the same time using the plasmons generated as an efficient reaction field in catalysis. The outcome will make it possible to drastically increase activities of (photo)catalysts, enabling their efficient operation under sunlight or even in weak room light conditions. For this, the project firstly adevelops novel photo-induced synthesis for metal NPs, both in solution and at surfaces, as well as at arranging the NPs in effective antennae. Secondly, microscopy modes will be developed/implemented that allow monitoring the growth of the NPs in situ, that allow checking the quality of the arrays and that allow in situ monitoring of catalytic test reactions. These knowledge will be applied to 'real world' (photo)catalysts (gold NP catalysis and TiO2, respectively). This project will thus result in new light-induced synthesis and fabrication methods of NPs; in new and/or improved microscopy modes and spectroscopic schemes in order to study the relationship between plasmonic properties and chemical reactions.",Plasmonics-based Energy Harvesting for Catalysis,FP7,30 September 2016,01 October 2011,1499120.0 PLASMO-NANO-DEVICES,University of Burgundy * Université de Bourgogne,photonics,"Miniaturizing optical connections and controlling optical processes at the subwavelength scale are expected keytechnologies not only for the future of data processing but also for the development of various sensors needed innanotechnologies. Among other strategies, a promising perspective shows up from the research works on opticalnanodevices involving surface plasmon polaritons sustained by nanostructures, also called plasmonics. Duringthe last years, European laboratories succeeded to build a significant advance over concurrent groups of othercontinents. To ensure the definitive European leadership in this field of research whith a high potential ofindustrial applications, it is now essential to federate the human and technical resources spread in Europe into aNetwork of Excellence aimed at developing prototypes of surface plasmon nanodevices for controlling opticalprocesses at the subwavelength scale. In the framework of well identified scientific and technical objectives, theparticipating organizations propose as aim of the present network of excellence to test an alternative structure ofthe management, evaluation and decision making mechanisms of research projects in order to improve theincisive and target oriented character of the research program.",Surface Plasmon Nanodevices : Towards Sub-wavelength Miniaturization of Optical Interconnects and Photonic Components,FP6,30 June 2008,30 December 2003,3920000.0 PLASMOCOM,Queen's University Belfast,photonics,"This project is aimed to develop a novel concept for micro- and nano-scale dynamic and active photonic components based on metal/polymer structures. The innovation lies in utilizing unique properties of metallic systems that allow optical and electric signals to be transmitted along the same metallic circuitry. This approach will provide a route to novel integrated micro-optical devices and components combining photonics and electronics on the same chip. The target is to establish a new technological platform and create the technology for the integratable nanophotonic components with enhanced functionality for optical signal processing, on-electronic-chip optical interconnects and optical broadband applications. We plan to achieve this on a single material system using polymer-based guides on a metal surface to confine and manipulate surface plasmon waves on a subwavelength scale. The passive, dynamic and active photonic devices will be fabricated and their performance characterized and tested. Examples of electrically controlled nanophotonic devices (wavelength selective components, integrated power monitors and variable optical attenuators) will be demonstrated. The proposed technology has a unique potential using its intrinsic capability of carrying an optical information as well as control electronic and/or optical signals in the same circuitry without a need of separate electronic and optical circuits. PLASMOCOM will create new critical knowledge on fabrication and performance of dynamic and active nanophotonic devices, demonstrate new devices with enhanced parameters (low fabrication cost, smaller size, enhanced dynamic and active functionality with lower electric consumption power and low intensity of control light, convergence of electronic and photonic circuitry), and will contribute to Europe¿s competitiveness and leadership in miniaturization of photonic components and integrated photonic circuits in order to establish it as a world market leader.",Polymer-based nanoplasmonic components and devices,FP6,28 February 2010,28 August 2006,1849710.0 PLASMODESMA PROTEINS,The University of Edinburgh,information and communications technology,"Plasmodesmata are pores that interconnect plant cells and allow for the diffusion of small molecules as well as the selective intercellular trafficking of macromolecules. Recent research has shown them to be highly dynamic and regulated structures with enormous influence on cell-cell communication and plant development as well as on both the systemic establishment of viral infections and the plant and aposs defense responses (RNA silencing).The plasmodesmal permeability for macromolecules can be altered by interaction with both plant-endogenous and viral proteins and it seems that some molecules, such as transcription factors, can be trafficked directionally and in a highly selective manner. The cellular machinery underlying macromolecular trafficking is so far poorly understood, due to the inaccessibility of plasmodesmata in the cell wall and the apparent lack of conserved trafficking signals in protein or RNA sequences. This project aims to identify novel proteins that are able to self-traffic between cells, or have the ability to interact with, and dilate (gate), plasmodesmata.This will be achieved by using a novel viral vector-based transient expression system in combination with state-of-the-art live-cell-imaging techniques, together comprising a high-throughput approach that will expand the range of tools available for postgenomic functional studies in plant molecular biology. Through the identification of new trafficking and gating proteins we expect to pin down some of the elusive components of the trafficking machinery and the plasmodesmal pore itself. The results will form the basis of a mechanistic understanding of macromolecular trafficking and eventually lead to new applications in agronomically important areas such as the defense against viral crop diseases and the manipulation of plant development.",High-throughput screening for novel proteins that dilate plasmodesmata or traffic cell-to-cell,FP6,14 December 2007,15 December 2005,168798.0 PLASMOLIGHT,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"At this point in time where plasmon optics has become a mature field of research, we propose here to create new bridges with other scientific disciplines in which the optical properties of plasmonic nanostructures could successfully address major roadblocks. The proposed scientific project consists of two independent parts, in which plasmonics is combined with Nanochemistry and Quantum optics, respectively. First, we will investigate how plasmonics could contribute to control with nanometer accuracy the deposition of a wide range of molecules or other nano-objects at a surface pre-patterned with noble metal nanostructures. Our approach is foreseen to overpass some of the major limitations of existing methods by combining parallel patterning over large areas with a resolution down to 10nm. Beyond demonstrating the feasibility of this novel approach, we propose to exploit it to increase the sensitivity of bio-chemical plasmonic sensing and surface enhanced Raman scattering. The second part of the project will study the use of the recent concept of plasmon nano-optical tweezers to develop a novel integrated quantum platform. The developed platform will be tested for applications to quantum simulation.",NEW FRONTIERS IN PLASMON OPTICS: FROM NANOCHEMISTRY TO QUANTUM OPTICS,FP7,31 March 2016,01 April 2011,1146495.0 PLASMONANOQUANTA,Autonomous University of Madrid * Universidad Autónoma de Madrid,photonics,"The overall objective of this proposal is to work in depth along three ground-breaking lines of research that are at the cutting edge of the current research in Plasmonics. These three subjects have strong overlap and are: 1) Non-linear phenomena and Plasmonic lasing: the introduction of optical-gain media into plasmonic waveguides has proven to be a feasible way to overcome the inherent losses within the metal. In order to reveal the physics behind this phenomenon, we intend to develop a new ab-initio theoretical framework that should combine the resolution of classical Maxwell's equations with a quantum-mechanical treatment of the molecules forming the optical-gain medium. Within this formalism we also aim to analyze in depth very recent proposals of plasmon-based nano-lasers, the design of active devices based on surface plasmons and the use of optical-gain media in metallic metamaterials. 2) Transformation Optics for Plasmonics: we plan to apply the idea of Transformation Optics in connection with the concept of Metamaterials to devise new strategies for molding the propagation of surface plasmons in nanostructured metal surfaces. Additionally, we will use the Transformation Optics formalism to treat quasi-analytically non-local effects in plasmonic structures. 3) Quantum Plasmonics: several aspects of this new line of research will be tackled. Among others, fundamental studies of the coherence of surface plasmons that propagate along different metal waveguides after being generated by quantum emitters. A very promising line of research to explore will be plasmon-mediated interaction between qubits, taking advantage of the quasi-one-dimensional character of plasmonic waveguides. Strong-coupling phenomena between molecules and surface plasmons and the design of practical scenarios in which entanglement of surface plasmons could take place will be also addressed. We also plan to study how to generate surface plasmons with orbital angular momentum.","Frontiers in Plasmonics: Transformation Optics, Quantum and Non-linear phenomena",FP7,31 March 2017,01 April 2012,1347600.0 PLASMONICS,International Center for Research on the Frontiers of Chemistry * Centre International de Recherche aux Frontières de la Chimie,photonics,"Surface plasmons have generated considerable renewed interest through a combination of scientific and technological advances. In particular with the progress nanofabrication techniques, the properties of surface plasmons (SP) can now be controlled by structuring metals at the nanometer scale. The overall objective of this proposal is to manipulate and control the properties of the SPs to analyze fundamental phenomena through which new capacities can emerge. The project is divided in four parts with strong overlap: 1) SP enhanced devices: We plan to use the benefits provided by SPs to enhance devices or create new device architectures. Textured metal surfaces, and the associated SP modes, can be used as antennas to extract, capture and control light in a variety of applications that include imaging and polarization sensing, nano-optical elements and detectors. 2) SP circuitry: To achieve complete miniature SP photonic circuits, a number of components to launch SP, control their propagation and finally decouple SP back to light are necessary. Much progress has been made in this direction but many challenges remain at the level of individual components and complete circuits that will be explored. 3) Molecule SP interactions: Molecule - SP strongly coupled interactions are expected to modify extensively photophysical and photochemical processes that will be studied by time resolved techniques. This issue also has implications for generating all optical control needed in SP circuitry. 4) Casimir effect and SPs: The tailoring of the Casimir force by enhancing the contribution of SP modes has been proposed by theoretical studies. Experiments will be undertaken to test the relationship between Casimir physics and plasmonics using nanostructured metal surfaces which could have significant consequences for nano-electro-mechanical systems. For each of these subjects, the objectives are at the cutting edge of the surface plasmon science and technology.",Frontiers in Surface Plasmon Photonics - Fundamentals and Applications,FP7,31 December 2014,01 January 2009,2200000.0 PLAST4FUTURE,Technical University of Denmark * Danmarks Tekniske Universitet,health,"Micro- and nanometer structuring has proven to be an efficient method to functionalize surfaces, and is attractive to manufacturers of plastic products. Plastic components are volume manufactured by injection moulding. Compact Discs and Digital Video Discs are today manufactured with nanometer range lateral resolution but, only on planar surfaces. Free-form (double-curved) moulding tools today offer resolutions down to 100 μm, limited by the methods used for creating the injection moulding tools. The objective of the project is to upgrade existing injection moulding production technology for manufacture of plastic components by enhancing the lateral resolution on free-form surfaces down to micro- and nanometer length scales. This will be achieved through the development of a complete nanoimprint lithography solution for structuring the free-form surface of injection moulding tools and tool inserts. This will enable a cost effective and flexible nanoscale manufacturing process that can easily be integrated with conventional mass production lines. The proposed technology enables functionality of plastic surfaces by topography instead of chemistry. This will significantly simplify the introduction of new products to the market, safer to produce and use. The proposed technology allows production of plastic surfaces with several different functionalities using the same material. This simplifies recycling and supports a cradle-to-cradle production philosophy. The proposed technology will be developed to meet specific industry demands from partners representing the plastic industry including the automotive, lighting and toy industries. During the project the European Trade Organisation representing the European plastic industry will disseminate the PLAST4FUTURE technology towards inter-sectoral end-users. An OEM service, provided by participating SMEs and Large Enterprises, will be established to secure a lasting value supporting European competitive strength.",Injection Moulding Production Technology for Multi-functional Nano-structured Plastic Components enabled by NanoImprint Lithography,FP7,31 December 2015,01 January 2013,6000000.0 PLASTAMORPH,Claude Bernard University Lyon 1 * Université Claude Bernard Lyon 1,information and communications technology,"This project focuses on the study of the mechanical behaviour of silica-based amorphous materials, which have attracted the interest of the scientific community both for their intrinsic physical properties and for the possibility to use them in technological applications, for example in micro- and nano-electronic devices, coatings and glasses. The mechanical response of amorphous materials, such as silica and silicate glasses, is still under investigation and it has not been fully understood yet because of the difficulty to visualize the microscopic rearrangements at the atomic scale. For example, the plastic response cannot be described in terms of dislocations as in crystals. Moreover, the small-scale response can be responsible for the macroscopic mechanical properties, like e.g. plastification, rupture and densification, but a clear link between the atomic-scale behaviour and the macroscopic phenomenology has not been established yet.",Complex mechanical response of silica-based amorphous materials: from the atomic to the mesoscopic scale,FP7,11 June 2015,12 January 2011,0.0 PLATFORM2NANO,University of Zaragoza * Universidad de Zaragoza,health,"Chemically synthesized nanomaterials (NMts) are being considered as the active elements in many applications, including, photonics, catalysis, energy, medical diagnosis and treatments. In order to achieve the promise of these applications, it will be critical to have an efficient, reproducible synthesis technique to produce the NMts. Currently, nanoparticles are synthesized in a batch mode in small volumes, which is suffering from irreproducibility and lack of NMts quality from batch to batch. Furthermore there are challenges in scaling batch procedures up to quantities needed for application development. Consequently, a new technological approach is required to assure nanotechnology feasibility. This project takes as a goal the development of multi-functional platforms based on microfluidics (MF) to address the wet-chemistry weaknesses and restrictions of small-scale batch reactors. Basically, MF allow an exquisite control on synthesis variables. The superior reaction control in a microliter or even nanoliter volume, enable to nanoengineer NMts in a continuous production process, addressing some issues such as scaling up and reproducibility. Additionally, MF promote some valuable advantages, including enhancement of mass and heat transfer, feedback control of temperature and feed streams, safer operational environment and potential for sensor integration. A variety of MF approaches will be developed to fine tune the NMts: sequential addition, slug flow, microwave and ultrasound irradiation. Since the applicant is a member of the highly-interdisciplinary Aragon Institute of Nanoscience, several collaborations with researchers from other areas have already been established. This enables the NMts obtained from this emerging technology to be employed in applications related not only to catalysis, which is the applicant´s main field of activity, but also in other areas such as nanocomposites and nanomedicine, where nanoparticles play a key role.",Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications,FP7,30 September 2016,01 October 2012,100000.0 PLATON,"Centre for Research & Technology, Hellas * Ethniko Kentro Erevnas Kai Technologikis Anaptyxis (CERTH)",photonics,"PLATON aims to realize a fully integrated Tb/s optical routing system for data networks expecting to deliver important advantages to the end-users as it will enable high-speed communications and ultra-fast access to data information being stored at large computer centers whilst investing in a new technological platform of lower cost, lower power consumption and reduced size requirements. This will allow for the effective consolidation of today's Internet and computer server rooms storing huge amounts of information into smaller-size rack- or even box-interconnect environments. PLATON's routing fabric will employ novel plasmonic switching elements on a silicon motherboard and will develop novel fabrication processes for enabling the merger of plasmonics with silicon nanophotonics and electronics, targeting the combined utilization of small-footprint, high-bandwidth plasmonics structures with the low-loss functional potential offered by the more mature SOI technology. PLATON will evolve upon a whole new generation of miniaturized photonic components including: (a) a new series of fast 2x2 thermooptic plasmonic switches, (b) a small-footprint 4x4 thermooptic plasmonics switch, (c) an optically addressable 1x2 plasmonic switch operating at bitrates in excess of 10Gb/s, and (d) a 2x2 and a 4x4 Tb/s optical routing platforms. To this end, PLATON will pioneer the field of routing for optical interconnects and will provide a completely new technological toolkit, bringing Europe in a leading position world-wide with respect to research efforts in plasmonics for interconnects. Finally, it will open totally new application vistas and opportunities for European industry being active in the field of nanophotonics, given that the active participation of industry within PLATON ensures the industrial take up of the combined plasmonics/photonics functional devices from research elements to commercially available products.",Merging Plasmonic and Silicon Photonics Technology towards Tb/s routing in optical interconnects,FP7,30 June 2013,01 January 2010,2599816.0 PLIANT,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,energy,"In this proposed integrating project we will develop innovative in-line high throughput manufacturing technologies which are all based on atmospheric pressure (AP) vapour phase surface and on AP plasma processing technologies. Both approaches have significant potential for the precise synthesis of nano-structures with tailored properties, but their effective simultaneous combination is particularly promising. We propose to merge the unique potential of atmospheric pressure atomic layer deposition (AP-ALD), with nucleation and growth chemical vapour deposition (AP-CVD) with atmospheric pressure based plasma technologies e.g. for surface nano-structuring by growth control or chemical etching and, sub-nanoscale nucleation (seed) layers. The potential for cost advantages of such an approach, combined with the targeted innovation, make the technology capable of step changes in nano-manufacturing. Compatible with high volume and flexible multi-functionalisation, scale-up to pilot-lines will be a major objective. Pilot lines will establish equipment platforms which will be targeted for identified, and substantial potential applications, in three strategically significant industrial areas: (i) energy storage by high capacity batteries and hybridcapacitors with enhanced energy density, (ii) solar energy production and, (iii) energy efficient (lightweight) airplanes. A further aim is to develop process control concepts based on in-situ monitoring methods allowing direct correlation of synthesis parameters with nanomaterial structure and composition. Demonstration of the developed on-line monitoring tools in pilot lines is targeted. The integrating project targets a strategic contribution to establishing a European high value added nano-manufacturing industry. New, cost efficient production methods will improve quality of products in high market value segments in industries such as renewable energy production, energy storage, aeronautics, and space. DoW adaptations being made responding on requests from Phase-2 Evaluation Report In Phase-2 of the evaluation process, a number of points were noted by the evaluators where the project had insufficient information or could benefit from 'upgrading' or justification. Our response and actions against each point raised has been summarized and send to the project officer, Dr. Rene Martins, in a separate document.",Process Line Implementation for Applied Surface Nanotechnologies,FP7,31 January 2017,01 February 2013,9066110.0 PM-NANOMAPS,Julius Maximilians University of Würzburg * Julius-Maximilians-Universität,health,"Besides its function as a passive cell wall plasma membrane (PM), involved in signal transduction and cell adhesion, is essential to enable the formation of tissues. Understanding PM function requires molecular insights into its dynamic spatial organization. Recent studies show that membrane proteins rearrange laterally forming nanoclusters of various size. On the other hand, a hierarchical model of two dimensional PM organization has been proposed including transient confinement in membrane-actin-skeleton induced compartments and lipid rafts. However, an overall picture of the dynamic spatial organization of the PM requires the inclusion of protein trafficking since membrane proteins undergo a constitutive turnover transported in vesicles as cargo from and to the cytosol. The hypothesis of this project is that vesicle trafficking to and from the PM is responsible for the observation of nanoclusters in the PM. Due to the diffraction barrier it is impossible to image nanoclusters with conventional fluorescence microscopy. To avoid this limitation, I will use super-resolution fluorescence imaging methods such as direct Stochastic Optical Reconstruction Microscopy (dSTORM) and Photoactivated Localization Microscopy (PALM) combined with novel statistical cluster analysis to study quantitatively the dynamic reorganization of PM induced by protein trafficking, as well as the role played by actin-skeleton-induced compartments and lipid rafts during this process. I will apply this approach to study a wide family of membrane proteins involved in signal transduction and cell adhesion essential for embryogenesis, neurogenesis, and immune response. The outcome of the project is expected to provide fundamental new insights into PM architecture and organization including protein turnover. Since membrane proteins are one of the most attractive drug targets because they control the communication of cells with their environment, the results will be of high medical significance.",Dynamic spatial organization of plasma membrane proteins at the nanoscale,FP7,31 August 2016,01 September 2014,161968.0 PMELT,University of Bristol,health,"We propose to undertake an ambitious 5 year interdisciplinary programme that introduces a fundamentally new paradigm in protein-based nanomaterials research. The new approach involves two main project themes based respectively on fundamental studies on the structure, function and properties of molten protein polymer surfactant nanoconstructs, and the development of these novel nanomaterials as smart fluids, biotechnological devices and health care products. This proposal represents a new and adventurous area of work for the PI, and will allow unprecedented access to a novel class of nanomaterials with controllable architectures, unique physical properties and inherent biological functionality. In so doing, the work will open up promising new avenues of bionanomaterials research and offer significant advantages over current methods for producing protein-based nanomaterials at extremely high concentration and dosage. In general we expect the research programme to pioneer new frontiers in fundamental research and generate significant economic and societal impact as nanomaterials become increasingly integrated into medical and technological products, and new commercial markets based on nanoscience are discovered.",New Frontiers in Protein-based Nanomaterials,FP7,29 February 2016,01 March 2011,2168862.0 PNEUMONP,Fundacion Cidetec,health,"The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum antibiotics. For the treatment a nanotherapeutic based inhalable antibiotic will be developed. The therapeutic nanosystem will be based on a nanocarrier combined with an antimicrobial peptide. 3 different types of NCs will be tested with 2 AMPs to be able to obtain a novel effective inhalable antimicrobial NS. Nanotherapeutics offers many advantages in pulmonary drug-delivery, due to the huge surface area available in the lungs and their potential to achieve uniform distribution of drug dose among the alveoli. To improve this delivery to the lungs an aerosol system will also be developed. Due to the characteristics related to pulmonary delivery of NCs, topical and systemic bioavailabilities are envisaged. A diagnostic kit will be generated to monitor the efficacy and efficiency of the therapy. Once this treatment is proved to be effective, it could then be applied to any Gram-negative lung bacterial infection. The number of antibiotic resistant bacteria strains is increasing rapidly, new types of therapy are urgently required to avoid the use of standard antibiotics. Gram-negative bacteria that cause pneumonia are one of the main sources of nosocomial infections, mainly in people with a weakened immune system. Apart from pneumonia they can cause bacteremia and other infections. Early detection of the infection source combined with the development of appropriate and effective NSs to treat multi-drug resistant (MDR) bacteria caused infections will definitely radically improve the healing process of patients and avoid complications for people in hospital.",Nanotherapeutics to Treat Antibiotic Resistant Gram-Negative Pneumonia Infections,FP7,31 December 2017,01 January 2014,5682351.0 PNPCS,Royal Institute of Technology * Kungliga Tekniska Högskolan,photonics,"Photonic crystals are materials patterned with periodic dielectric structures. Since they were first proposed, in 1987, they have grown into a burgeoning research field with a rich spectrum of applications. Recent research in the field has been rapidly expanding to include nonlinear effects. Combining the compact formats and versatility of photonic crystal structures with the functionalities of optical nonlinearities could ultimately prove to be the key to tunable all-optical devices with huge impact across a broad range of disciplines, from telecommunications and quantum computing, to biology and sensing. Traditional approaches to nonlinear photonic crystals involve micro- (nano-) structuring the linear properties of a nonlinear medium. The research I wish to pursue through an IEF with the world-leading group on nanostructured ferroelectric optical materials would reverse this paradigm, to explore a brand new class of 2D periodic structures, i.e. Purely Nonlinear Photonic Crystals (PNPCs), based on micro- (nano-) structured nonlinearities. Key to the project will be the development of an integrated nonlinear nano-photonic platform in lithium niobate, a ferroelectric crystal in which the sign of the nonlinearity can be periodically modulated in space and exploited in integrated optical formats. The development of a such a nonlinear technology toolkit would enable a new class of 'parametric' photonic crystals which could manipulate all-optically the pathway, pulse shape, delay, spectrum and phase of multicolour light beams by means of purely nonlinear mechanisms (not via interference and diffraction as in ordinary photonic crystals). This could open a completely unexplored realm, holding promise for excitingly new physics and unprecedented possibilities for device engineering.",Purely Nonlinear Photonic Crystals,FP7,30 April 2011,01 May 2009,237485.0 POCAONTAS,IMDEA Nanoscience Institute * IMDEA Nanociencia,energy,"Organic solar cells (OSC) feature several advantages over 'classical' silicon solar cells: low cost, energy effective production, low weight and semi-transparency. This makes them apt for novel applications like, building-integrated photovoltaics (BIPV) with high market potential. However, both the efficiency and the long-term stability must be enhanced for OSCs to become profitable. POCAONTAS will develop highly efficient and stable OSCs based on tailored blends of polymers (P) with single wall carbon nanotubes (SWNT), that are ideally suited for OSCs due to their inherent stability, high carrier mobility and the tunability of optical gaps. Up to now, no breakthrough in SWNT based OSC has been achieved due to challenges with the control of SWNT-chirality, -aggregation, orbital energy mismatch and nanoscale sample morphology. Our consortium will address these issues: We will synthesize functional polymers that (i) allow for a tailored selection of SWNT chiralities, and (ii) match the SWNT energy levels to polymers for maximization of efficiency. The introduction of SWNT-P exchange protocols enables us to optimize (i) and (ii) with different polymers, avoiding compromises in performance. We will obtain optimized donor-acceptor blends, in which the SWNTs are light antenna and charge transporter. We unify leading European groups in time- (down to 10 fs) and spatially (down to 10 nm) resolved spectroscopies providing unique insights into SWNT-P interactions at the molecular level. Experts in multi-scale quantum chemical modeling will develop greater predictive power of charge transport. FLEXINK, a startup in optoelectronics materials, will provide tailored polymers. KONARKA, world leader in commercial OSCs, will build and test solar cells using our blends. Both full partners can directly exploit the project's outcome to strengthen their market position. Three associated industrial partners provide industry internships for each ESR maximizing their career perspectives.",Polymer - Carbon Nanotubes Active Systems for Photovoltaics,FP7,31 October 2016,01 November 2012,3421494.0 POCKET,Ghent University * Universiteit Gent,health,"Pocket will develop a novel point-of-care (PoC) urine test for the detection of tuberculosis (TB), achieving at the same time a low cost (5 to 10 euro end-user cost per test, including depreciation cost of the instrument) and a high accuracy (>80% capture of TB-positive patients, which is much better than the present solutions which reach 60%). The test positions itself between current low-end immunological urine tests with limited accuracy and between high-end expensive nucleic-acid-based tests, which are not truly point-of-care. Throughout this project, special attention will be paid to both end-user requirements (performance, cost, ease-of-use, …) and to manufacturability. Pocket will go well beyond the development of a mere laboratory prototype, as in the final year of the project, the instrument will be field-tested in Africa and India. The combination of low cost and high accuracy will be achieved through a unique integration of several state-of-the-art concepts, which the partners have separately developed and of which the maturity has already been shown: -a nanophotonic transducer with integrated spectrum analyser developed by UGent (Vernier ring resonator cascade with arrayed waveguide grating spectrometer). This will enable us to eliminate the cost associated with the inclusion of a high-end tunable laser (20k euro) that typically plagues the competing approaches using resonant optical nanophotonic sensors. -a high-confinement silicon nitride (SiN) platform running in a mature small-volume CMOS fab (imec). The use of SiN as opposed to the more traditional Silicon-on-Insulator material system will enable us to move the operating wavelength from 1550 nm to 900 nm, where both the sources and the detectors are significantly less expensive. -a novel TB detection system, based on a unique combination of high-quality antibodies for two different biomarkers.",Development of a low-cost point-of-care test for Tuberculosis detection,FP7,31 October 2016,01 November 2013,2702184.0 POCO,Fundación Tekniker,energy,"Light composite materials for load bearing applications can be made using different type reinforcements and polymer matrices. Carbon nanotubes (CNT) have been studied extensively because of their exceptional mechanical and electrical properties, yet their practical and extensive use in commercial materials is missing. The utilization of CNTs as reinforcement to design novel composites is a quite old idea. However, there is a lack of a knowledge based approach to achieve the nanostructuration level required to optimize the CNT/polymer composite performances. The main objective of POCO is to get innovative polymer composites filled with CNT in order to obtain nanostructured materials with tailor made properties. The CNT/polymer interface is, together with the CNT and the polymer, the third and most important element that will determine the final properties. Hence the chemical functionalization of CNT surfaces is of utter importance to achieve not only a proper dispersion and anchorage of the nanotubes into the polymer matrix during processing, but also to optimize the performance itself in solid state. Our approach involves the development of different CNT confinement strategies to develop novel polymer matrix nanocomposites. Several polymers have been selected as representative of thermosetting and thermoplastic materials. This ensures that the output of POCO could be applied in a wide range of applications: automotive, aeronautics, building, aerospace, wind power generation (blades), ship building, biomedicine…This project will be focused on four fundamental properties: (i) high strength for structural and mechanical components, (ii) tuneable electrical properties, (iii) low wear under fretting (low amplitude reciprocating movement) and (iv) superhydrophobicity. Multifunctionality of these materials will be an important benefit as the requirements for composite polymeric materials are quite diverse",Carbon Nanotube Confinement Strategies to Develop Novel Polymer Matrix Composites,FP7,31 October 2012,01 November 2008,5524450.0 POISE,University of Sheffield,information and communications technology,"Recent years have seen spectacular advances in the performance and functionality of quantum cascade lasers (QCLs) based on intersubband transitions in III-V semiconductor quantum wells. There remain, however, a large number of relatively unexplored areas in QCL research which offer the potential to raise performance to still higher levels, as well as shedding light on new areas of semiconductor device physics. For example, rapid non-radiative intersubband scattering by LO-phonon emission places fundamental limits on optical gain in current QCL designs, which could potentially be overcome by reducing dimensionality by application of high magnetic fields or by novel structures exploiting semiconductor quantum dots. Similarly, there is considerable need for a full understanding of the processes that lead to optical gain in THz QCLs, where the intersubband separation is below the LO phonon energy. The potential for short wavelength operation would be greatly enhanced by improved knowledge of the electronic parameters of Sb-based heterostructure systems which could lead to the development of intersubband sources and modulators at telecoms wavelengths. Another exciting prospect arises from exploiting the non-linear optical properties of QCL structures to produce a wide range of operating wavelengths by second harmonic and sum/difference frequency generation. Related studies of structures incorporating photonic crystal waveguides and/or exploiting surface plasmon effects also promise to lead to key advances in QCL functionality. The proposed research training network brings together 9 European leaders in the fields of quantum cascade lasers and non-linear optics to form a coherent body of expertise which is strongly placed to investigate these fundamental areas which promise to underpin the next generation of QCLs and other intersubband devices. The proposed research programme will provide the focus for over 400 months of Early Stage and Experienced Researcher training.",Physics of Intersubband Semiconductor Emitters,FP6,30 September 2008,01 October 2004,2311558.01 POLALAS,Durham University,health,"This project is aimed at theoretical and experimental studies of the Bose-Einstein Condensation (BEC) of exciton-polaritons in photonic microstructures, which provide two-dimensional or three-dimensional localization of light such as microdiscs, microspheres, cylindrical and spherical Bragg microcavities, and microcavities based on photonic crystals. For this purpose we will: 1) Calculate eigenmode spectrum for photonic microstructures in the case of bare optical modes and for exciton-polaritons. 2) Derive the conditions for the weak coupling-strong coupling threshold for each type of the photonic microstructure. 3) Obtain phase diagrams for exciton-polariton 4) Develop a theory for the exciton-polariton interaction with phonons in the above mentioned photonic microstructures, and analyse the relaxation mechanisms, and develop a technique for the qualitative description of polariton relaxation. 5) Analyse BEC in microstructures based on various materials, and particularly wide band gap semiconductors with large electron binding energy such as GaN and ZnO. 6) Provide modelling and a physical understanding of experimental results related to this proposal. 7) Analyze the condition of formation of BEC of exciton-polariton under the electrical injection of carriers. 8) Produce a technical specification for a realistic room-temperature polariton laser. 9) Investigate spin-related phenomena in polariton condensate in novel types of microcavities. 10) Analyse the possibility of electrical pumping of polariton devices based on photonic microstructures. 11) Produce prototypes of polariton laser operating at room temperature under electrical pumping and investigate them experimentally.",Novel photonic nanostructures for polariton lasers,FP7,30 April 2012,01 January 2009,322200.0 POLAPHEN,University of Iceland * Háskóli Íslands,photonics,"The investigation of light-matter interactions nano- scale objects attracts the growing interest of researchers. This interest is largely motivated by the possibility of reaching the strong light-matter coupling regime, where the elementary excitations -polaritons -have a hybrid, half-light half-matter nature. The unusual properties of the polaritons make them a unique laboratory for study of fundamental quantum effects such as high temperature Bose Einstein condensation, superfluidity, entanglement etc. The important property of the polaritonic systems is their polarization (spin) properties. The interplay between bosonic stimulated scattering of cavity polaritons and their spin precession under effective magnetic fields of various origin makes polarization dynamics in quantum microcavities extremely rich and interesting from fundamental point of view. Moreover, the possibility to manipulate spin of polaritons opens a way to experimental realization of optoelectronics devices of new generation, i.e. spinoptronic devices. With respect to optics, spin-optronics has the advantage of being able to use well controlled carrier interactions occurring in nanostructures. With respect to 'spintronics', it has the advantage of strongly reducing the dramatic impact of carrier spin relaxation or decoherence, which has severely limited the achievement or the functionality of any working semiconductor-based spintronic devices. Our research will be aimed at theoretical study of the coherent polarization (spin) phenomena in quantum microcavities with embedded quantum wells and dots in order to formulate practical recommendations for design of various spinoptronic devices: all- optical locical gates, optical circuits, polarization filters and sources of entangled photon pairs. In order to achieve this goal we created the distributed consortium (network) of partner institutions, located in EU and associated countries (Iceland, France, UK) and in Eligible Third Countries (Mexic",Polarization Phenomena in Quantum Microcavities,FP7,31 December 2014,01 January 2011,370800.0 POLARCLEAN,University of Brighton,information and communications technology,The aim of the project is to develop advanced methdologies for the decontamination and monitoring of emerging polar contaminants in wastewaters and drinking waters.,Advanced methods for the removal and monitoring of polar organic contaminants,FP7,08 July 2015,09 January 2011,0.0 POLARIC,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,manufacturing,"The objective of the project is to realise high-performance organic electronic devices and circuits using large-area processing compatible fabrication methods. The high performance of the organic circuits referred to here means high speed (kHz-MHz range), low parasitic capacitance, low operating voltage, and low power consumption. The related organic thin film transistor (OTFT) fabrication development will be focused to enable a high resolution nanoimprinting lithography (NIL) step, which is compatible with roll-to-roll processing environment. Applying NIL will enable smaller transistor channel lengths (down below 1 µm) and thereby an increase in the speed of the device. Another important concept to improve the performance is the self-aligned fabrication principle, in which the critical patterns of the different OTFT layers are automatically aligned in respect to each other during the fabrication. This decreases the parasitic capacitances and thereby increases the speed of the device, and is one of the key elements to enable the use of large-area fabrication techniques such as printing. Also complementary transistor technology will be developed, which will enable a decrease in operating voltage and power consumption. The high performance organic transistors will be tested in basic electronic building blocks such as inverters and ring oscillators. The technology development will be exploited in the active matrix liquid crystal display (AMLCD) and radio-frequency identification (RFID) demonstrators. In addition to showing that sufficient performance can be reached without sacrificing the mass fabrication approach, solutions for the fabrication of roll-to-roll tools in order to make serial replication viable will be provided. Finally, the design, characterization, and modeling of submicron low-power OTFTs will be done in order to support the fabrication of the demonstrators based on the technology developed in the project.","Printable, organic and large-area realisation of integrated circuits",FP7,06 June 2016,01 January 2010,9859375.0 POLARIS,University of Minho * Universidade do Minho,health,"3Bs is situated in one of the most industrialised regions of Northern Portugal (PT11) where the economy is strongly based on traditional, low-tech and small family businesses. Withstanding these traditions, the group has been a lighthouse and an example on the exploitation of the regional research potential within the biomedical area. Based on interdisciplinary research where collaboration and cooperation are hallmarks of its culture, 3Bs is worldly recognised for its excellence and innovative approaches in the field of macro and microscale processing of biomaterials. The project POLARIS aims to strengthen this position of 3Bs by boosting the group activity in the field of Nanomedicine. An action plan that involve upgrading the group infrastructure with state of the art equipments for processing and characterisation of biomaterials at nanoscale as well as recruiting experienced researchers and technical staff in this field has been created and will be attained by the close cooperation with 4 leading European institutions: Chalmers University of Technology, Max Planck Institute for Intelligent Systems, University College Dublin and University of Strathclyde Glasgow. Transfer of know-how and experience between the partners will be enhanced by several events targeting scientific community but also the general public. A local SME -StemMatters is also part of the partnership since the 3Bs aims to become dynamic 'innovation engine', facilitating and accelerating the transfer of innovative technology from basic research to industry. Thus, POLARIS seeks for actual implementation of the obtained results that can be a vital 'bridge' to growth, competitiveness, sustainability and employment in PT11.","Unlocking the research potential of 3Bs Group, University of Minho, in Nanomedicine field to strengthen its competitive position at the European level",FP7,30 September 2015,01 October 2012,2811238.0 POLAROMA,University of Rome Tor Vergata * Università degli Studi di Roma Tor Vergata,photonics,"This project is aimed at training of a new generation of researchers to develop the advanced solid-state light sources based on microcavities. Microcavity- and polariton-devices are a rapidly-expanding research and technology area of major potential impact to both international and European-based science and industry. Thus potential exists to capitalise on this skill base by adding value to current national efforts through collaboration, and to recruit, inspire and enable a cadre of young research scientists for careers in this technology. The mobility of the Chair-holder will allow to combine the efforts of two European networks and to create a Center of Excellence in polariton physics highly attractive for the young researchers. No such a centre exists in the world at present. Its creation in Roma will definitely help competitiveness of Europe in the important area of modern Opto-electronics. The Chair holder is going to lead a theoretical research on 1) Theory of Bose condensation of exciton-polaritons and polariton lasing, 2) Spinoptronics, 3) Photoinduced superfluidity of neutral and charged quasiparticles and train 3 PhD students funded by the Host in these three areas. He is also going to teach the undergraduate course “Modern semiconductor optics†and the post-graduate course “Polariton devices†for the students of physics and engineering faculties of the University of Rome II and project students from “Clermont2†and “NanoQuanta†networks.",Polariton devices: the future of optoelectronics,FP6,30 November 2009,01 December 2006,531712.53 POLDER,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"As microelectronic device dimensions continue to shrink, system performance is becoming limited by the interconnect delay. A major component of this delay arises from intralevel capacitance. The dielectric must therefore have a low dielectric constant in order to minimize the capacitance between the lines and maximize performance at reduced dimensions. Silicon oxycarbides with dielectric constant of 2.7-3.0 are already being used in advanced production processes. In order to reduce the dielectric constant further, porosity has to be introduced into the film. Initial research, performed on spin-on dielectrics, already revealed many integration issues related to the porosity of these materials. In order to achieve production-worthy processes, chemical vapour deposition is the preferred way to fabricate these films.In this project, plasma enhanced chemical vapor deposition (PECVD) is used to develop processes for ultra-low K deposition. This research project makes use of the most advanced production-compatible equipment on 300mm Si wafers. Through selection of the optimum precursors and process conditions, suitable films will be developed. The project will investigate the impact of the plasma parameters on film properties, such as uniformity, composition, dielectric constant, pore size and pore distribution, elastic modulus and strength. The films will be integrated in IMEC's back-end of line processes to investigate etch behaviour, CMP compatibility and reliability properties. Specific plasma characterization of the deposition and clean recipes will be performed to optimize both.",Porous Low-K Deposition and Characterization Research,FP6,30 April 2008,01 May 2006,80000.0 POLIGHT,Consejo Superior De Investigaciones Científicas (CSIC),photonics,"The POLIGHT project will focus on the integration of a series of inorganic nanostructured materials possessing photonic or combined photonic and plasmonic properties into polymeric films, providing a significant advance with respect to current state of the art in flexible photonics. These highly adaptable films could act either as passive UV-Vis-NIR selective frequency mirrors or filters, or as matrices for light absorbing or optically active species capable of tailoring their optical response. The goal of this project is two-fold. In one aspect, the aim is to fill a currently existing hole in the field of materials for radiation protection, which is the absence of highly flexible and adaptable films in which selected ranges of the electromagnetic spectrum wavelengths can be sharply blocked or allowed to pass depending on the different foreseen applications. In another, the POLIGHT project seeks to go one step beyond in the integration of absorbing and emitting nanomaterials into simple flexible polymeric matrices by including hierarchically structured photonic lattices that provide fine tuning of the optical properties of these hybrid ensembles. This will be achieved by means of enhanced matter-radiation interactions that result from field localization effects at specific resonant modes. The opportunity arises as a result of the recent development of a series of robust inorganic photonic structures that present interconnected porous networks susceptible of hosting polymers and thus inheriting their mechanical properties.",Polymer-Inorganic Flexible Nanostructured Films for the Control of Light,FP7,30 November 2017,01 December 2012,1497730.0 POLLUX,Stiftelsen for Industriell og Teknisk Forskning (SINTEF),information and communications technology,"The objective of POLLUX is to develop a distributed real time embedded systems platform for next generation electric vehicles, by using a component and programming-based design methodology. Reference designs and embedded systems architectures for high efficiency innovative mechatronics systems will be addressed with regard to requirements on composability, networking, security, robustness, diagnosis, maintenance, integrated resource management, evolvability and self-organization.",Process Oriented Electrical Control Units for Electrical Vehicles Developed on a Multi-system Real-time Embedded Platform,FP7,09 June 2015,03 January 2010,0.0 POLY-INTER-FACES,University of Maribor * Univerza v Mariboru,health,"Natural polysaccharides (PS) and their derivatives provide a huge variety of functional groups leading to a great number of different physicochemical properties. Therefore functional polysaccharides are promising for the coating of man-made materials such as polymer surfaces, glass or ceramics in order to increase their functionality or biocompatibility. An elegant way to obtain coatings of natural polysaccharides is shaping of trimethylsilylated PS derivatives and subsequent regeneration of these structures to the initial PS. The target of this study is to produce electrospun and spin coated polysaccharide coatings from blends of hydrophobic trimethylsilylated PS and other hydrophobic PS derivatives and to subsequently regenerate these structures to the PS with the initial (bio-)function. This will produce functional polysaccharide coatings with tunable micro- and nanofibrous structures on a variety of materials. The influence of the structure and PS composition of these coatings on the physicochemical properties will be determined by surface analytical tools (Contact Angle Measurements, X-ray Photoelectronspectroscopy). The biocompatibility of the materials will be evaluated by extended protein adsorption studies with a quartz crystal microbalance. The regeneration process from trimethylsilylated PS will it further allow to introduce micropatterns on the PS surface coatings by lithographic methods. Spatially separated regeneration of the PS derivative coatings will produce patterns of electrospun or spin coated functional PS on substrates surrounded by non-regenerated hydrophobic PS derivatives. With the approaches described in this proposal, a vast number of tunable functional polysaccharide interface will be produced which will have potential applications as anti fouling coatings, as wound dressing material, as (bio-)sensor support, as low fouling functional filter webs or as biocompatible cell scaffolds in medicine.",Micro- and Nanostructured Polysaccharide Interfaces,FP7,31 May 2015,01 June 2013,154137.0 POLYAMPHI,University of Bayreuth * Universität Bayreuth,manufacturing,"The research of the proposed network is aimed at the study of the super-molecular organization in amphiphilic macromolecular systems of complex architectures. In particular, our efforts will focus on the study the hierarchical self-assembly of amphiphilic macromolecules differing in their molecular architecture, driven by multiple types of interactions, both in aqueous solution and at interfaces. The spectrum of molecular architectures will range from simple linear structures (e.g.,block copolymers) over branched structures (e.g. graft copolymers) and more complex nanoparticles (spherical and cylindrical core-shell and Janus-type structures). We aim to understand how self-organization, the resulting structures and interfacial patterns are controlled by the interplay of macromolecular architecture of building blocks with different types and ranges of competing interactions, particularly hydrophobic and electrostatic interactions. We aim at the design of highly responsive (intelligent) systems capable for switching of the aggregation state and supermolecular organization upon variation of the external conditions. Our ultimate goal is to create and understand systems that can self-assemble in a hierarchical way. The present project aims at exploring possible approaches and should be seen as the first step in this challenging direction.The strongly complementary expertise of the participating groups (advanced synthetic techniques, a wide range of experimental characterization methods, the combination of analytical and computational theoretical modeling, as well as competence in industrial applications) and their coordinated efforts will guarantee the success of the proposed interdisciplinary research by bringing us to a qualitatively new level of understanding of self-organization of amphiphilic macromolecular systemsThis network, spanning six countries with 13 teams, is aimed to provide excellent training for the early-stage researchers in an inspiring, #",Self-Organized Nanostructures of Amphiphilic Copolymers,FP6,29 February 2008,01 March 2004,2401628.08 POLYAPPLY,STMicroelectronics Srl,information and communications technology,"Things that think and the communication of people with such things in his environment critically depend oncontactless communication technologies. RF communication devices and protocols have been developed in thepast and exist today, yet in their present form they cannot and will never be used on a large scale to allowcommunication with everyday objects. The fundamental reason for this is the cost of the silicon technologyemployed to realize it. Even in its most optimistic projection, this cost remains at least one order of magnitudehigher than the cost of a technology that has been proven to be truly ubiquitously applicable, such as a barcode.Therefore, a new generation of devices is required to enable ambient intelligence at the right cost point in orderto be truly applicable everywhere and anywhere.The objective of PolyApply is to lay the foundations of a scalable and ubiquitously applicablecommunication technology. The boundary condition is the cost of the microsystem, combining basic RFcommunication with sensor functions. The key to achieving a fundamentally different cost point than what will bereachable in the future with the evolution of the existing technologies (e.g. CMOS), is to resolutely move to adisruptive new manufacturing technology: going from batch processing to in-line manufacturing technology.The semiconductor system envisaged to this end is based on polymers. The scalable aspect refers to the factthat PolyApply does not plan to propose a solution for a certain generation of RF communication devices usefulat one point in time, but rather intends to develop generic technologies with a meaningful impact in the mid- andlong term. In other words, the developed technologies will lead to an extendable family of products, ranging from'simple' RF tags at ultra-low cost to RF communication devices with complex functionality such as integrated re-writable memory, sensory inputs, display, etc...",The application of polymer electronics towards ambient intelligence,FP6,31 March 2008,31 December 2003,1.2E7 POLYBRUSH,Technical University of Berlin * Technische Universität Berlin,health,"Polymer brushes are long polymer chains tethered to a surface by one end. They have applications in chemistry, engineering, medicine, microelectronics, etc. Many of these applications involve interactions between the brush and nanoparticles which are near or within the brush (for instance, when used to arrest toxic substances or to arrange nanoparticles in the patterned surface). Structure of these composite brush-nanoparticle systems has been largely studied but only a few works have been carried out concerning their dynamics. To be able to design the systems for the applications efficiently, a good understanding of their dynamics is essential. This project aims to provide a comprehensive description of the dynamic behaviour of brush-nanoparticle systems as a function of key parameters such as nanoparticle size, concentration, and penetration depth, polymer chain molecular weight, and grafting density. Gold nanoparticles within PDMAEMA brushes will be used as model systems and the different samples characterized using small angle x-ray scattering (SAXS), ultraviolet-visible spectroscopy (UV-Vis), atomic force microscopy (AFM), ellipsometry, x-ray reflectometry (XRR), and neutron reflectometry (NR). Thereafter, long- and short-time dynamics of brush and nanoparticles will be measured using the more recently developed techniques of evanescent wave dynamic light scattering (EWDLS), resonance enhanced dynamic light scattering (REDLS), and neutron spin echo under grazing incidence (GINSE). This will allow to gain insight into particle-polymer brush interactions which will foster development of models that can be used to optimize current applications or even originate new ones.",Dynamics in polymer brush-nanoparticle systems,FP7,31 March 2015,01 April 2013,161968.0 POLYCAT,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"POLYCAT provides an integrated, coherent and holistic approach utilizing novel polymer based nanoparticulate catalysts in pharmaceutical, crop protection and vitamin syntheses in conjunction with the enabling functions of micro process technology and 'green' solvents such as water or ethyl lactate. This provides a discipline bridging approach between fine chemistry, catalysis and engineering. This will lead to the replacement of a number of chemical or microbiological reaction steps in fine chemical syntheses by catalytic ones using more active, selective and stable nanoparticulate catalysts. In addition, POLYCAT will lead to the development of novel chiral modifiers immobilized on the polymeric supports. Micro process technology provides testing under almost ideal processing conditions, with much improved heat management, with improved costing, at high data validity, at high process confidence, and with high certainty for scale-out. The industrial applicability is demonstrated by scale-out of the industrial demonstration reactions to the pilot scale. A multi-purpose, container-type plant infrastructure will integrate individual reaction and separation modules in block format, standardised basic logistics, process control, safety installations, and on-line analytics. As guidance before (ex-ante) and during the whole development, holistic life cycle (LCA) and cost analyses will pave directions towards competitiveness and sustainability. The POLYCAT technologies have potential to reduce the environmental impact by 20% up to orders of magnitude: e.g. reduction of green house gas emissions, acids (SO2-Eq.), nutrients (NOx-Eq.), toxic substances (1,4-DCB Eq.) and finite abiotic resources (antimony eq.). With (enantio)selectivity increases up to 25%, solvent reductions of 30-100%, and products cost decreases of about 10%, a midterm impact of 30-110 Mio Euro and longterm impact of 100-560 Mio Euro result.",Modern polymer-based catalysts and microflow conditions as key elements of innovations in fine chemical syntheses,FP7,31 March 2014,01 October 2010,6998220.0 POLYCOND,AIMPLAS - Plastics Technology Centre * Asociación de Investigación de Materiales Plásticos y Conexas,information and communications technology,"PolyCond address the needs of the European plastic converters, a traditional less RTD intensive sector mainly composed of SMEs (>99%) through an ambitious multidisciplinary approach to develop new, radically innovative knowledge-based & sustainable products & services for protection against the affects of Electromagnetic Interference (EMI) & Electrostatic Discharge (ESD). This will be achieved by the development of conductive plastic composites that are eco-friendly, cost effective & with high added value. Research is based on blends of engineering polymers & Inherently Conductive Polymers (ICPs) with improved conductivity or hybrid systems of ICPs with conductive nanotubes. Innovative eco-efficient processing based on CO2 assisted technologies specifically tailored to the new materials will also be developed. Although there is existing research on ICPs; with the knowledge & technologies presently available (materials & processing) it is impossible to fulfil the demanding properties required to replace metals in EMI shielding applications. PolyCond will dramatically extend the current performance & processability of ICPs to replace metals in EMI shielding & ESD protection applications. The main barriers to overcome are: Low conductivity of existing melt processable ICPs Temperature sensitivity of existing melt processable ICPs Compatibility & dispersion problems of conductive nanofillers in complex matrixes PolyCond's approach will give: Plastic components with embedded EMI shielding functionality Weight reduction of at least 60% Total cost reduction of shielding components approaching 90% Production time reduction of 80% improving productivity PolyCond benefits plastic processors in the EU, developing new technologies addressing key long-term problems with permanent impact. A multidisciplinary & integrated approach includes technology transfer & training activities mobilising EU & Regional funding.",Creating competitive edge for the European POLYmer processing industry driving new added-value products with CONDucting polymers,FP6,31 January 2009,01 February 2005,4994129.0 POLYCONDNA,University Newcastle upon Tyne,health,"In this project we propose to develop conducting nanoscale molecular wires based on hybrid polymer materials. The concept is to use DNA as a scaffold for the attachment of polymerisable monomer units covalently bound to the DNA nucleosides. Novel synthetic nucleosides will be prepared for oligomerisation using automated solid phase DNA synthesis. It is intended to synthesise modified nucleosides, in particular the pyrimidines, which can be applied to the sequence specific synthesis of DNA strands. The nucleoside will be modified with units derived from pyrrole and thiophene since these compounds are readily polymerized to conducting materials. In using DNA as a scaffold or backbone the self-assembling properties of DNA may be exploited for the construction of large and complex nanoscale architectures. In this way it should be possible to direct the assembly of nanoscale wiring by using the inherent biological assembly process of the DNA part of the hybrid material. Established synthetic methodologies will used for the synthesis of the precursor compounds and these will be characterised using standard techniques to establish structural details, e.g. NMR, elemental analysis, ionized electrospray mass spectroscopy LC(IES-MS), spectroscopic (FTIR, UV-vis). The synthesis of DNA oligomers will rely on phosphoramidite chemistry and automated solid phase protocols. The formation of conducting polymer wires will involve oxidation of the resulting DNA-pyrrole/DNA-thiophene strands using chemical and electrochemical approaches. The resulting materials will be characterised using a range of spectroscopies (FTIR, CD, UV-vis) as well as voltammetry and probe microscopy. Finally, the conducting properties of the materials will be examined using a combination of 2-electrode devices and scanning probe methods.","Synthesis, characterization and conductivity studies of conducting polymer-DNA hybrids",FP7,30 September 2010,01 October 2008,169957.0 POLYDORM,Tel Aviv University,health,"Tumor progression is dependent on a number of sequential steps, including initial tumor-vascular interactions and recruitment of blood vessels, as well as an established interaction of tumor cells with their surrounding microenvironment. Failure of a microscopic tumor, either primary, recurrent or metastatic, to complete one or more of these early stages may lead to delayed clinical manifestation of the cancer and a state of stable non-progressing disease. Micrometastasis, dormant tumors, and residual tumor cells contribute to the occurrence of relapse, and constitute fundamental clinical manifestations of tumor dormancy that together are responsible for the vast majority of cancer deaths. However, although the tumor dormancy phenomenon has critical implications for early detection and treatment of cancer, its biology and genetic characteristics are poorly understood. We now propose to investigate the molecular and cellular changes in tumor-host interactions that govern tumor dormancy, which may lead to the discovery of novel tumor dormancy targets and provide tools for dormancy-dependent tumor therapy strategies. In order to achieve this goal, we will integrate the following basic and translational approaches: (i) Establishment of mouse models of dormant and fast-growing tumor pairs; (ii) Functional and molecular characterization of dormant versus fast-growing tumors, (iii) Design of dormancy-promoting tailor-made polymer therapeutics delivering a combination of microRNAs with chemotherapies; (iv) Polymer conjugation to a prodrug designed to be activated by specific enzymes overexpressed in tumors, Turning-ON a near infra-red (NIR) fluorescence signal. When completed, this proposal will shed light on this fundamental cancer biology phenomenon. A better understanding of tumor dormancy and the availability of markers and therapeutic targets will most likely change our perception of tumor progression and, consequently, the way we diagnose and treat the disease.",Uncovering the molecular and cellular mechanism of tumor dormancy for the rational design of theranostic nanomedicines,FP7,31 March 2019,01 April 2014,2255920.0 POLYDOT,Institut Català d'Investigació Química (ICIQ) * Institute of Chemical Research of Catalonia,photonics,"The PolyDot project aims to foster necessary progress on frontier research that integrates a number of leading concepts in the field of photoelectrochemistry in association with new concepts from areas such as nanoscience and materials chemistry. As an example, key scientific elements of the PolyDot project are the synthesis of new molecular electronic components, such as semiconducting quantum dots, the design of self-organising functional interfaces through supramolecular interactions and the evaluation of these systems for its potential technological application as light driven energy supplier devices. Thus, the proposal is at the meeting point between supramolecular chemistry, nanostructured inorganic materials science and optoelectronic device physics. It is therefore highly multidisciplinary and involves my research group, which is working in the device physics characterisation and materials science fields. We believe that this project will develop a critical mass of expertise targeting this innovative approach towards solar powered devices allowing Europe to establish a scientific world lead and will also form a secure basis for renewable energy technological exploitation.",Control of the Electronic Properties in Hybrid- Quantum Dot/Polymer-Materials for Energy Production,FP7,31 October 2014,01 November 2009,1299960.0 POLYFIRE,NetComposites Ltd.,transport,"Polyfire will develop and upscale techniques for processing halogen-free, fire-retardant nanocomposites and coatings based on unsaturated polyester resins and nanoclays. These materials will improve public safety and environmental impact by eliminating halogenated fire-retardants, which produce toxic combustion products. The ability of well-dispersed nanoparticles to enhance the fire-retardancy of thermoplastic polymers is well-established, but thermoset polyester has received relatively little attention. In a recent collaborative project, the fire-retardancy of polyester resin was dramatically improved on a lab scale by adding small amounts of organomodified nanoclay, along with significantly reduced amounts of other, non-halogen fire-retardant additives. However, significant further work is required to scale-up production and to assess the health and environmental impacts. This project will develop and upscale the nanoclay modification and will use novel mixing techniques to enable industrial-scale production of the nano-filled polyester. The project will generate turn-key solutions for easy integration into industrial SMEs. Nanocomposites and coatings will be produced and subjected to stringent tests. The technology will be demonstrated by producing 3 large-scale case study parts from construction, rail and marine sectors. Comprehensive health and environmental impact assessments will be conducted.",Processing and Upscaling of Fire-Resistant Nano-Filled Thermosetting Polyester Resin,FP7,08 July 2014,09 January 2009,2254281.0 POLYMAP,University of Warwick,energy,"The goal of the proposal is to develop unique capability and understanding of electroactive materials and their composites, for photovoltaic applications, through the use of emerging nanoscale electrochemical imaging techniques. By combining the strong background and experience of the Fellow (Josh Byers) in materials science, with the impressive facilities, equipment, infrastructure and expertise at the Host Institution, exciting new directions in hybrid photovoltaic materials will developed and explored. Nanostructured organic and inorganic materials are attractive for potential low cost photoelectrochemical energy generation for large scale exploitation. However, these materials are characterized by nanoscale features (typically tens of nm's), and it has only now become possible to study their electrochemical response on a similar length scale using scanning electrochemical cell microscopy (SECCM), recently invented by the Host Institution. The Fellow will join the Host group to expand the current capabilities to include high resolution photoelectrochemical imaging to study in detail the local (photo)electrochemical processes that occur at the interfaces of electrode materials for next generation photovoltaic devices (eg. dye sensitized solar cells), elucidating the impact of nanoscale morphology and structure on activity. Exploiting the nanoscale dimensions of the SECCM system, new methods for fabricating conjugated polymer nanostructures and composites will also be investigated to develop novel electrode materials. Through a combinatorial approach made possible by SECCM, these materials will be studied in-situ following their fabrication. The results of the project will provide a new view of photovoltaic devices at the nanoscale, ultimately allowing the rational design of improved solar cells. Dissemination to a wide audience is planned to maximise impact and opportunities in Europe.",Mapping and Manipulating Interfacial Charge Transfer in Polymer Nanostructures for Photovoltaic Applications,FP7,31 May 2015,01 June 2013,231283.0 POLYMORE,Aston University,health,"PolyMoRe will establish viable technology for a new class of tailored materials that will address pressing global demands in human healthcare and sustainable industrial development. Both sectors are priority areas in EU policy. Specifically PolyMoRe will bridge the gap currently preventing commercial exploitation of nano-sized metal clusters (MeCs) -unique materials with superb properties (photoluminescence, photoredox activity etc). To fully exploit the terrific potential of MeCs, methods will be developed to incorporate them into organic polymers to create novel materials with a plethora of applications that include bioimaging, cancer treatment, LEDs and solar cells. These materials will provide alternatives to expensive and environmentally harmful materials currently in use. Thus PolyMoRe will contribute significantly to the development of a 'knowledge-based' economy that will create wealth and improve well-being in the EU. The knowledge that results from PolyMoRe will promote the EU as a leading centre for both academic and industrial research in healthcare and materials science. Another key objective of PolyMoRe is to provide a unique training for a highly skilled female researcher (returning to science after a short career break to start a family) with extant expertise in synthesis/manipulation of MeCs. PolyMoRe will significantly complement her existing skills in inorganic chemistry by training her in organic/polymer synthesis, modern analytical techniques and biotechnology, where the host institution, associate institutions and the company 'Deliverics' have leading expertise. This will leave the Fellow uniquely qualified to pursue a high profile academic/industrial career as PI within the EU thus tackling the shortage of materials developers with genuine interdisciplinary skills. An additional legacy of PolyMoRe will be a new collaboration between the Fellow's former research group in Russia, world-leaders in metal clusters, and Aston (UK).",Polymeric ligands for molybdenum and rhenium clusters,FP7,30 April 2015,01 May 2013,231283.0 POLYPATT,University of Limerick,photonics,"Strong electric field gradients can produce forces that overcome the surface tension in a thin liquid polymer film to induce instabilities at the film surface. It is possible in this way to create structure in polymer films on a nanometre length scale. Understanding how the resultant patterns form has significant potential for improving nanodevice fabrication techniques but may also lead directly to the discovery of novel nanodevices. As part of the PATTERNs RTN, over 35 months the applicant has worked with some of the leading researchers in the thin film polymer instabilities field, and has been fully trained in the relevant experimental and theoretical methods. He has developed a new theoretical model that describes a polymer-air-polymer system under electric field and he has explored this system, not only theoretically but experimentally. The applicant has validated his theoretical model, and explored comprehensively the polymer type, thickness and viscosity parameter space of this system to provide new insights into the nucleation and spinodal processes responsible for the observed pattern formation. The experimental results are however from static measurements, and so detail of the dynamic instability formation process remains obscured. He proposes therefore to study the real-time formation of the polymer instabilities using a newly acquired optical 3-D topographic instrument modified for this purpose. In addition, the ambition of fabricating nanodevices based on these polymer instabilities requires an increased level of experimental control, and the coupling of these instabilities with nanoparticle inclusion for self-organisation into nanodevices (such as photonic crystals) is at the forefront of current research and still not well understood. He proposes therefore to develop new methods for controlling the experimental polymer instability system, and to use this control to allow fabrication and characterization of nanoparticle self-organised devices.",Control and Application of Field Induced Polymer Patterns,FP7,31 March 2011,01 April 2009,30000.0 POLYSELF,Northwestern University,manufacturing,"One of the most challenging goals in the field of materials science is the discovery of structures with surprising properties or functionality based on designed molecules that self-organise. These structures are held together by relatively weak noncovalent interactions and thus might be easily reconfigurable into a variety of morphologies. A promising starting point for the synthesis of such structures seems to be the use of templates made of organic molecules that arrange themselves into highly organized nanostructures and may direct the cells to attach, proliferate and selectively differentiate, by providing them signalling domains that regulate their function. This will allow the development biomaterials that are not only biocompatible and biodegradable, they can present guidance to cells. The design of self-assembling molecules that mimic complex biological structures hold promise for the development of novel multifunctional biomaterials that could lead to real breakthroughs in tissue repair and regeneration. In the spirit of the Marie Curie OIF, this research project aims to provide an unique prospect and an excellent training programme for an European researcher to develop her investigation, in the areas of self-assembly, templating chemistry and biomaterials, by gathering two leading research institutions in the field. The research work will be developed at the Northwestern U. (Prof. Stupp, USA) in the outgoing phase and at the U. of Minho (Prof. Reis, Portugal) in the return phase. The researcher will have the opportunity to go to a third country established research centre to acquire new skills and knowledge, professional maturity and independence, enhanced inter/multidisplinarity qualities, while broadening her international research experience. This is turn will foster the links between European and third countries's researchers and will contribute for the development of abundant and dynamic world-class human resources in the European Research system.",Functionalization of polysaccharide-based biomaterials and development of supramolecular materials using self-assembling peptides,FP6,30 April 2008,01 October 2006,241704.02 POLYSURF,University of Maribor * Univerza v Mariboru,health,"The overall objective of the project is to increase the knowladge and research level of the Institute of Textiles at the University of Maribor, on the creation of tailored and/or smart fibre forming polymers and materials that would be able to control the realise of various active compounds, or to create tailored fibre surface properties for different end-applications in the area of technical textiles, such as medical, therapeutic, hygienic and protective textiles. The project will transfer the knowladge of technologiest based on (1) colloidal micro-hydro-gelation, (2) nano-micro-(en)capsulation and (3) polymer surface coating. Additionally, (4) innovative biotechnological, green-chemistry and chemical catalysis tools, or their combination, will be applied to activate and/or modify polymer surfaces and/or colloidal particles/layers created by ecologically and toxicologically suitable processes. According to the diversity of the knowladge and expertise that shall be transfered, the project will build a highly multidisciplinary scientific group, cutting across different established research areas, i.e. textile chemists, physical chemists, biological catalysts and colloidal engineers, that will be able to prepare colloidal particles, coatings and multilayers, and subsequently apply them to different suitably pre-activated and/or modified natural and synthetic polymer surfaces. The new fibre materials with upgraded properties can be exploited either to enhance the bulk properties of existing products for better performance, or to create new value-added products with smart and/or tailored surface characteristics based on the multifunctionality. The project will increase the host research quality and overal RTD capability related to the EU competitiveness as well as contributes to the strengthening of textile and textile-oriented SMEs in order to deal with rapid change and growing competition of their products by integrating advanced technologies into the existing ones.",Development of Smart Polymer Surfaces,FP6,31 December 2009,01 January 2006,1097970.02 POLYTECT,D'Appolonia SpA,construction,"Textile structures are extensively used in construction in forms of geotextiles. The retrofitting of existing masonry walls and soil structures is particularly important for earthquake protection of historic buildings and protection of earthworks against landslides. Unreinforced masonry structures are highly vulnerable because being originally designed mainly for gravity loads they often cannot withstand the dynamic horizontal loads in case of strong earthquakes. Soil structures, such as embankments, are subjected to landslides after heavy rainfalls or during earthquakes. Hence the necessity to develop efficient methods for the retrofitting of existing masonry buildings and earthworks and of related monitoring systems to possibly prevent the structural damage. The broader aim of POLYTECT is the development of new multifunctional textile structures for application in construction for the retrofitting of masonry structures and earthworks. The different functions the textile structures need to incorporate comprise a combination of the following: to increase ductility and structural strength; to monitor stresses, deformations, acceleration, water level variation, pore pressure, to detect presence of fluids and chemicals, to measure structural health. Enabling technologies include the combination of warp-knitted grid-like reinforcing basic structure and rope-like reinforcement, the incorporation of optical fibres into textiles; the incorporation of sensors e.g. by coating fibres with nanocrystalline piezoceramic materials. The proposed breakthroughs include the: use of textile material as load-bearing part of the building; use of multifunctional textiles for stabilisation and monitoring; use of nanostructured materials to tailor the interface properties; incorporation of sensors based on nanocrystalline piezoceramics and optical fibres, development of an impedance-based health monitoring technique.",Polyfunctional Technical Textiles against Natural Hazards,FP6,31 August 2010,01 September 2006,6599769.0 POLYTRIGG,University of Basel * Universität Basel,health,"Advanced designed vaccines have to combine proper antigen with the effective immune-stimulating agents (adjuvants) and delivery strategies in order to attain successful treatment. Presently, most vaccines are given as liquid formulations by intramuscular administration. However, nano-sized carriers of antigens hold great promise to be more effective delivery systems. To achieve the desired anti-cancer therapy; the ideal antigen nano-carrier has to fulfil a number of requirements. First of all carriers need to be (hollow) particles like with diameters in the range 50-500 nm in order to be taken up by dendritic cells (antigen-presenting cells capable to induce immune response). To facilitate the development of cellular immune responses, vaccine antigen must be presented on MHC (Major Histocompatibility Complex) class I. To win the goal, the nano-carrier should selectively bind to these cells, and be taken up into endosomes. To doing this carriers should be able to display certain adjuvants as targeting and stimulating ligands on their surface, and be capable to release its cargo upon response to pH changes in the endosome. Furthermore, vesicles have to carry and release antigen (i.e. proteins) to target destination with minor side-effects (biocompatibility and non-toxicity of carrier are essential). Hence, it is the goal of proposed project to develop nano-carriers on the basis of block copolymer vesicles (polymersomes) that have all those features. The aim is to developed polymersomes based on amphiphilic poly(2-methyloxazoline) PMOXA or (polydimethysiloxane) PDMS blocks in combination with stimulus-responsive copolymers blocks and a tunable polymersome surface chemistry. Therefore, the final goal is to provide 'smart' drug delivery system with versatile surface chemistry, which will allow the attachment/incorporation of different adjuvants (e.g. saponins) and consequently enable target delivery.","Bioactive block copolymer vesicles as pH-triggerable, nano particulate carriers for cancer vaccination",FP7,30 June 2014,01 July 2012,192622.0 POP SILICA,University of Strasbourg * Universitè de Strasbourg,health,"Despite their great potential, full exploitation of mesoporous silica nanoparticles (MSiNPs) as in-vivo multi-functional theranostic agents is still held back by the lack of a controlled and complete biodegradability. Indeed removal of nano-medical tools from the biologic system after the accomplishment of their diagnostic or therapeutic function still remains a pivotal, yet unresolved issue impeding their clinical translation. A most desirable design for improving the properties of nano-medical tools would hence involve their ability to hierarchically self-degrade into renally clearable products after carrying out their function. Thus, the ambitious aim of this project targets the synthesis of novel, specific, hybrid MSiNPs-based theranostic tools, able to perform their beneficial action and subsequently fragment in smaller pieces allowing easy execration via renal system. In this way, thanks to the combination of the intrinsic biocompatibility of MSiNPs, their ease of functionalization and the newly conferred enhanced biodegradability, a superior material adaptable to a wide range of diagnostic and therapeutic applications, with great promise for clinical translation, will be achieved.",Towards Biodegradable Nanoparticles: Hybrid Organic Mesoporous Silica,FP7,28 February 2015,01 March 2014,97023.0 PORABEL,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"In this proposal we aim to address several complex biophysical problems at single molecule level that remained elusive due to the lack of appropriate experimental approach where one could manipulate independently both interacting biomolecules and in the same time measure the strength of their interaction and correlate it with their electronic signature. In particular we are interested in finding out how biopolymer finds, enters and translocates nanopore. Equally intriguing is still unresolved mechanism of phage DNA ejection. We will also investigate how exactly proteins recognize the target binding places on DNA and if the protein DNA recognition is based on the complementarity of their charge patterns. To allow addressing those biophysical problems we will develop novel experimental framework by integrating electrodes to the nanopore based force spectroscopy. The proposed strategy will enable two directions of the research: single molecule manipulation and single molecule detection /sensing equally suitable for investigating complex biophysical problems and molecular recognition assays. By exploiting superior sensing and detection capabilities of our devices, we will investigate following practical applications improved nucleotide detection, selective protein detection and protein charge profiling via nanopore unfolding. Unique combination of optical manipulation and nanofluidics could lead to new methods of bioanalysis, mechanical characterization and discrimination between specific and non-specific DNA protein interactions. This research proposal combines nanofabrication, optics, nano/microfluidics, electronics, computer programming, and biochemistry",Nanopore integrated nanoelectrodes for biomolecular manipulation and sensing,FP7,30 September 2015,01 October 2010,1439840.0 POROUS SILICON NANOV,University of Helsinki * Helsingin Yliopisto,health,"The progress of nanotechnology during the last decades has had a strong impact to the current research of biomedical applications, in particular against dreadful diseases such as cancer. It is estimated that more than 12 million cases of cancer are diagnosed every year worldwide. Multidrug resistance, rapid elimination by the immune system, enzymatic degradation, and poor targeting efficiency are still the major obstacles of the nanomedicines used in cancer therapy. The integration of imaging and therapeutic agents into a single carrier (theranostics) allows simultaneously detection, diagnostics, and treatment of the diseases, which may enhance both expectancy and quality of life of the patients. In the proposed project a systematic approach is taken towards developing and testing of novel multistage–multifunctional nanovectors based on the fusion between stage-2 nanoporous silicon nanoparticles and stage-1 polymersomes (fused materials = protocells, cell-like particles) for directed (targeted/personalized) therapy and multimodal imaging. With this approach it is aimed to decouple the quadruple functions of the protocell nanovectors in order to generate relevant preclinical information for rapid translation into the clinic: sufficient multifunctionality to avoid biological barriers, recognition of their targets, accounting for non-invasive in vivo imaging and delivery of therapeutics. The overall distinct and final milestones are: to ligand-anchored, co-loading of drug(s)-dye(s), and dual radiolabelling of the precisely tailored protocell nanovectors for simultaneously targeting the tumour vasculature cells, stimulating the immune system response and multimodal imaging in vivo. It is also aimed to evaluate the suitability and effectiveness of the designed nanodevices by employing in vitro models and in vivo imaging techniques and to achieve a comprehensive and deeper understanding on the cellular interactions between the protocell nanovectors and the cancer cells.",Multistage-Multifunctional Porous Silicon Nanovectors for Directed Theranostics,FP7,31 December 2017,01 January 2013,1499603.0 POTENT,Istituto Italiano di Tecnologia (IIT),health,"Despite significant advances in chemotherapy, the effective treatment of malignant masses via systemically injectable agents are still limited by insufficient accumulation at the biological target (<< 10% injected dose per gram tumor) and non-specific sequestration by the reticulo-endothelial system (tumor/liver < 0.1). The goal of this proposal is to engineer Discoidal Polymeric Nanoconstructs (DPNs) to preferentially target the malignant neovasculature for the delivery of imaging agents, controlled release of therapeutic molecules and thermal energy. The central hypothesis is that the size, shape, surface properties and stiffness (4S parameters) of the DPNs can be controlled during synthesis, and that therapeutic molecules (Temozolomide), Gd(DOTA) complexes and ultra-small Super-Paramagnetic Iron Oxide nanoparticles (USPIOs) can be efficiently incorporated within the DPN polymeric matrix. This will be achieved by pursuing 3 specific aims: i) synthesis and physico-chemical characterization of poly(lactic-co-glycolic acid)/poly(ethylene glycol) DPNs with multiple 4S combinations; ii) in-silico and in vitro rational selection of DPN configurations with preferential tumor deposition, low macrophage uptake and high loading; and iii) in-vivo testing of the DPN imaging and therapeutic performance in mice bearing Glioblastoma Multiforme (GBM). The innovation stays in i) using synergistically three different targeting strategies (rational selection of the 4S parameters; magnetic guidance via external magnets acting on the USPIOs; specific ligand-receptor recognition of the tumor neovasculature); ii) combining therapeutic and imaging molecules within the same nanoconstruct; and iii) employing synergistically different therapeutic approaches (molecular and thermal ablation therapies). This would allow us to support minimally invasive screening via clinical imaging and enhance therapeutic efficacy in GBM patients.",Engineering Discoidal Polymeric Nanoconstructs for the Multi-Physics Treatment of Brain Tumors,FP7,30 June 2019,01 July 2014,2390000.0 POWER DRIVER,European Thermodynamics Limited,energy,"Car CO2 emissions are to be limited to 120 g/km for all new passenger cars by 2012. If they are unable to achieve targets, then this may have a significant negative impact on manufacturers. Cars also produce emissions such as Nitrogen oxides, Hydrocarbons, Carbon monoxide and particulate matter which are subject to tight controls. For marine application, existing and forthcoming legislation is aiming at reducing the emissions of Carbon Monoxide, Hydrocarbons and particulate matter. In addition, concerns about rising fuel costs are driving the need for greater fuel efficiencies. As a result, a disruptive technology step is required that will enable the manufactures or cars and marine engines to meet the forthcoming legislative standards. One very attractive way of achieving this is to generate power from the Internal Combustion Engine (ICE) waste heat. A prototype system created by BMW can generate up to 250W of electricity under normal driving conditions that can cut fuel consumption by up to 2%. However, the thermo-electric materials used for these applications to date have a number of clear limitations as they can be easily thermally damaged, are expensive and only achieve low efficiencies. The POWER DRIVER project aims to overcome the limitations relating to the production of an automotive and marine power generation system by integrating cutting-edge nano-structured silicide and functionally graded telluride thermo-electric materials into a heat exchanger assembly that will enable electrical power to be generated from the exhaust system without affecting back-pressure or engine balance. By doing this, the exhaust system created will offer greatly improved environmental performance due to improved fuel efficiency and reduced emissions (CO2, nitrogen oxides, hydrocarbons, carbon monoxide and particulates) at a cost that is affordable to the end-user. It is predicted that (even if the additional weight of the unit is considered) fuel efficiency will increase by at least 5%, leading to a corresponding 5% reduction in emissions.",An innovative environmentally friendly thermo-electric power generation system for automotive and marine applications that is powered by exhaust waste thermal energy to reduce fuel consumption.,FP7,31 January 2014,01 February 2012,2349895.0 POWERSWIPE,University College Cork,transport,"Europe is a world leader in innovative automotive systems with competencies covering the full supply chain from the main OEMs (Audi, BMW, Daimler, Fiat, PSA, RSA, VW) to Tier1 suppliers (Bosch, Continental, Magneti Marelli) to leading semiconductor companies (Infineon, ST). The vision for electronic automotive control units in 2020 is that the battery will supply multi-core µControllers via multiple power supplies using an on-chip, granular power management system architecture, known as PowerSoC (Power Supply on Chip). The PowerSwipe proposal will address a key roadblock for PowerSoC by, for the first time, miniaturising and integrating state-of-the-art, high density trench capacitor substrate technology with novel thin film magnetics on silicon to deliver a multi-component LC (inductor-capacitor) interposer which will be combined, in a 3D heterogeneous stack, using eWLB technology, with the µController chip. To achieve this miniaturisation of the power passives, the switching frequency of the switched mode dc-dc converter needs to be increased from the traditional 1 to 5 MHz space (with 90%+ converter efficiency) into the 20MHz to 100MHz+ range, at which point the footprint of the power passives is comparable to the footprint of the individual on-chip DC-DC converter blocks (i.e. 1 to 2mm2). PowerSwipe will deliver a European supply chain for PowerSoC by addressing the challenges of system design, engineering, technology and manufacturability of integrated power management systems or PowerSoC (Power Supply on Chip) for nanoCMOS System on Chip (SOC).",POWER SoC With Integrated PassivEs,FP7,09 June 2017,10 January 2012,3295000.0 PRAIRIES,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),photonics,"PRAIRIES is an interdisciplinary and intersectorial network exposing high-profile, early-stage and experienced researchers to a broad spectrum of training and transfer of knowledge activities beyond conventional academic boundaries, thereby educating them not only to supramolecular chemistry, nanoscale science and technology, but also to complementary skills (i.e., management, communication, IPR) and preparing them for positions in academia, industry, and government labs. A personal career development plan for each researcher will define the training milestones accomplished through local and network-wide activities and transfer of knowledge actions, both at academic and industrial nodes, along with the short and long term career objectives. The overall scientific and training objectives are centered around the design and synthesis of structurally programmed molecular modules which self-assemble at precisely define host and receptor sites in a regular manner. These unique 2- and 3-dimensional architectures will result from the application of strong directional intermolecular interactions between specifically designed molecular components allowing the controlled formation of the desired networks on surfaces. Such tailored-made, tunable receptor cavities (diameters between 1 and 10 nm) will be employed to host a series of functional molecules, modulated for the different applications targeted in this project. All supramolecular assemblies will be refined for specific technological applications through a step-wise approach involving also theoretical calculations and advanced characterization using single molecule spectroscopy, electrochemistry, nanoscale imaging and manipulation via scanning probe microscopy methods. Thus, PRAIRIES will apply a cross-disciplinary approach to generate highest level of training and new knowledge in the burgeoning area of molecular biology, supramolecular-, materials-, and nano-science with impact in biosensing and optoelectronics.",Supramolecular hierarchical self-assembly of organic moleculesonto surfaces towards bottom-up nanodevices: an host-driven action,FP6,30 September 2010,01 October 2006,2701102.0 PRECISE-NANO,Aalto University * Aalto-yliopisto,information and communications technology,"The current devices used in electronics have reached nanometre dimensions where the precise nature and location of every atom matters. To further drive the development of existing technologies and to test proposals for next generation nanoelectronics, we need tools that allow structural and electronic characterization of materials down to the atomic scale. We need to be able to measure the position and nature of the atoms, as well as the local density of electronic states at a specific energy, the charge distribution, and atomic scale magnetic properties. In addition, we need methods that allow controlled manipulation of the relevant atomic-scale details of the active region of the material, where we could pick and place atoms or molecules and create vacancies at pre-defined locations.",Atomically precise nanoelectronic materials,FP7,01 July 2019,02 January 2012,0.0 PREMADIX,Stichting VU-VUmc * Foundation VU - VUmc,health,"Through ERC-funded research, Prof. Wuite developed the DN-X-PRO as a method and instrument that enables direct visualization of DNA-protein interactions in real-time, at the single-molecule level, at super-resolution, under conditions similar to the cellular environment. Using the DN-X-PRO, researchers can manipulate and measure mechanical and structural properties of DNA-protein complexes, while simultaneously localizing individual proteins on the DNA, with nanometer accuracy and super-resolution. To date, such studies can only be performed by separate application of two or three different instruments, in conditions that do not resemble the cellular environment, with lower resolution. This results in a strong proposition to biomolecular researcher labs worldwide, allowing conduct of a range of experiments that are very complicated or not possible to date. The PREMADIX project will result in a clear valorization strategy — based on elemental business insights that permit estimation of commercial and financial feasibility and business modeling and planning. Besides, a sound intellectual property (IP) strategy will be defined. In parallel, the DN-X-PRO will be physically prepared for marketing, translating the current prototype into a robust and user-friendly design accompanied by product sheets, control and analysis software, and user manuals. Finally, the PREMADIX team will assemble a business team, and start discussions with potential strategic partners and financers. By doing so, at the end of PREMADIX, the team will have strong assets for market introduction.",Preparing market introduction of DN-X-PRO - a breakthrough solution for real-time studies of DNA-protein interactions at single-molecule resolution,FP7,30 November 2014,01 December 2013,150000.0 PRENANOTOX,Tel Aviv University,environment,"The production of many consumer products based on manufactured NanoParticles (NPs) has led to a growing public and regulatory concern about the safety of nanomaterials. Since experimental toxicological testing of NPs, especially in vivo animal studies is costly and time-consuming, it is necessary to develop a novel research field and associated methods and tools to reach the goal of predictive nanotoxicology. The PreNanoTox consortium addresses three currently missing critical elements needed to develop a platform for predictive nanotoxicology and our suggested approach of providing them: (1) There is a current lack of unified large database – We suggest to form this database by applying cutting edge information extraction tools on large repository of scientific articles; (2) There is a need for better understanding the underlying mechanisms of the primary interaction of NP with the cell membrane – We suggest to apply appropriate theory and simulation assuming that the surface chemistry of a NP (affecting NP’s surface reactivity, hydrophobicity, or surface electrostatics) as well as its other physical properties (e.g. size and shape) determine the strength of the non-specific adsorption of NPs to a cell surface, leading beyond a certain adhesion-strength threshold, to efficient uptake of the NPs; (3) There is a need to extend the traditional QSAR paradigm to the field of nanotoxicology – This will be carried out by linking appropriate NP descriptors, with emphasis on those which determine the strength of adsorption of NPs to cells, with biological responses. The PreNanoTox consortium is made up of four research groups (from three scientific organizations), which lead in information technology, soft matter modeling, computational chemistry and in-vitro toxicology, yielding a synergetic output. This project will assist in safe designing of new engineered NPs as well as reducing tha extent needed for empirical testing of toxicity.",Predictive toxicology of engineered nanoparticles,FP7,12 July 2017,01 January 2013,997734.0 PRIDE,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"The overall objective is to built up expertise in the field of material science related to deep submicron CMOS processing and to investigate the irradiation hardness of these technologies. This requires a clear understanding of different disciplines such as material characterization, defect studies, silicon processing, electrical device characterization and irradiation studies. Due to the large number of processing steps in CMOS technology it is essential to either remove the process-induced defects or at least drive them towards the inactive regions of the components. This control effort is called defect engineering and gettering. Beside the process-induced defects, additional defects can also be created during the device operation having direct consequences on the lifetime of the components. The space community is more and more using the Commercially-of-the-Self (COTS) approach. This means that instead of dedicated components, fabricated in hardened technologies, commercial parts fabricated in mainstream CMOS are used for space electronics. Increasing the lifetime of components will reduce the cost, save energy and reduce the emission of greenhouse gases. A fundamental study of the nature and structure of such defects is thus necessary to advance in technological applications, in particular in the miniaturization of components. For the applicant it is a unique opportunity to work on state of the art research topics, for which there is world- wide large interest. The proposed research plan is covering a broad range of topics, combining activities on material science, silicon processing and irradiation physics. It also allows to build up expertise on how to conduct a large joint research program in an international environment. The training will not only be performed at a pure scientific level, but also at a higher level including social aspects such as team building, multi-racial and multicultural interactions, and managerial skills.",Processing and Irradiation Defect Engineering in Advanced CMOS Technology,FP6,31 August 2004,01 January 2004,144021.0 PRIMA,University of Vienna * Universität Wien,environment,"Recent findings concerning the role of inland waters in global carbon cycling is currently having a major impact of the view of the global carbon cycle. These findings highlight inland waters - such as streams, rivers and lakes - as major sites of carbon cycling, implying that they must be considered in the context of climate change. Microbial degradation of organic carbon is a process that is central to carbon cycling in all ecosystems. In soils, microbial degradation of recalcitrant carbon is often controlled by the availability of labile carbon sources. This is linked to the priming effect (PE). Mounting evidence suggests that PE is also important in aquatic ecosystems but it has yet to be explicitly addressed. Biofilms are vital components of aquatic ecosystems. In stream biofilms, heterotrophic bacteria and algae coexist in close proximity, exposing the bacteria to both recalcitrant organic carbon of terrestrial origin and labile organic carbon from the algae. This could make stream biofilms hotspots for PE. In PRIMA, I propose an innovative effort cutting across aquatic and terrestrial ecosystems, spanning single-cell to ecosystem scales, and combining methods from biogeochemistry and molecular microbiology to study PE in stream biofilms. Carbon flux in stream biofilm microcosms and in ecosystem scale stream mesocosms will be measured to quantify PE and its implications for carbon cycling in streams. The mechanisms of PE will be addressed on single-cell and community scales using cutting edge methods, such as NanoSIMS and 454-sequencing. I am an experienced researcher trained in Norway and Sweden. In PRIMA, I seek to combine my existing skills with the unique expertise and facilities of Prof. Tom J. Battin at the University of Vienna. The many conceptual and methodological training objectives of PRIMA, as well as its outstanding scientific quality, will strengthen my scientific skills and will enable me to reach my goals as an independent researcher.",Priming in an aquatic ecosystem - Stream biofilms as hotspots for carbon cycling,FP7,05 July 2015,06 January 2011,175844.8 PRIMA,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,energy,"The demand for affordable renewable energy is increasing steadily. Electricity generation by photovoltaic cells is one of the main players in this field, but is hampered by its still relatively high cost compared with other sources of energy. Within this project we investigate promising nanotechnology - based strategies to enhance the performance and/or reduce the cost of different solar cell technologies. Specifically we examine the use of metal nanostructures to enhance the optical absorption of light into different types of solar cells, including crystalline Si, high performance III-V, organic and dye-sensitized solar cells. The enhanced absorption can ultimately lead to thinner and therefore less expensive solar cells due to the use of less material. One of the remaining issues in this field, that of better physical insight in the possible plasmonic enhancement mechanisms, will be studied in detail using calculations and experiments on structures with different degrees of complexity. In parallel, we investigate the manufacturability of these nanostructures and the ease of integrating them into existing process flows for solar cells. This will allow us to examine industrially relevant structures, integrate them into solar cells and test their performance. The performance will be bench-marked and assessed by solar cell companies that are participating in the project. European science traditionally is a leader in both the fields of photovoltaics and nanoplasmonics and this project helps to maintain Europe's strong position. Moreover it provides the participating industrial partners with a competitive advantage, which should create employment and sustainable economic growth in Europe, while simultaneously contributing to a reduction of the emission of greenhouse gases.",Plasmon Resonance for IMproving the Absorption of solar cells,FP7,31 December 2012,01 January 2010,2300000.0 PRINS,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,photonics,"The project focuses on all needed preparatory actions to enable in the following phase the construction of a Research Infrastructure (RI) called Pan-European Research Infrastructure for Nano-Structures (PRINS), with the aim of enabling European innovative research for the ultimate scaling of electronics component and circuits. The platform will be truly interdisciplinary by allowing the convergence of 'top-down' technology, which is today the main enabler of Moore's law (i.e. transistor scaling), with 'bottom-up' methods derived from fundamental disciplines such as material physics, chemistry, biotechnology and particle electronics. The open access of this infrastructure provided to the Scientific Community will enable the cross-disciplinary fertilization of academic and industrial competences in the areas of nanoelectronics, nanosystems, nanobiology, nanophotonics, etc. The consortium consists of European leading Research Centres, industrial partners and Public Authorities and Funding Agencies. Key activities include 1) setting up a legal framework for the operation of the RI, 2) defining the required management structures for the daily operation of the RI, for screening and evaluating the incoming access requests, and for technical and financial aspects related to the strategy of the RI and its long term sustainability, including the role of the different stakeholders and possible funding schemes, 3) defining the legal and practical issues related to the different operation modes for giving access ad hosting researchers, and 4) defining the timeline of the RI, its different areas, and its associated business plan (operational costs, resources, funding possibilities, costs for giving access, etc).",Pan-European Reseach Infrastructure for Nano-Structures,FP7,31 March 2010,01 April 2008,1000000.0 PRIOSERS,Rovira i Virgili University * Universitat Rovira i Virgili,health,"This proposal aims the design of novel optical enhancers for surface-enhanced Raman scattering (SERS) to develop routine methods for quantitative detection of a very broad range of substances based on regular arrays of gold nanorods. As proof of concept the diagnosis of neurodegenerative diseases, such as Alzheimer or Creutzfeldt-Jakob diseases (CJD), which still pose a great challenge for international health systems because of the economic and social impact of its pandemic outbreaks. Such diseases do not induce any immunological response on the infected individuals and thus, antibody detection cannot be used because they are not produced by the host. Therefore, antibody-free detection systems are required, which are also highly sensitive and selective. Overall this presents a significant challenge which can be resolved using a new generation of SERS substrates with unprecedented degree of structural control. Therefore, the main objectives of the project will involve the fabrication of uniform gold nanorods within a wide range of sizes; their assembly into perfectly ordered supercrystals, both on planar and patterned substrates; evaluation of the SERS enhancing properties of such assemblies as a function of nanorod morphology and degree of order; comparison with theoretical modeling and prediction of the most convenient configuration; and finally the full implementation of the detection of prions using these substrates. We propose the use of SERS as a non-invasive sensor, which is able to detect and monitor prions in biological fluids (blood, urine or saliva). For this target to be achieved, the enhancing metallic substrates need to be engineered for focalization of the plasmonic modes at certain regions of the substrate and production of extremely high enhancement factors. This idea is based on the concept of field localization by nanoantennas, which will be perfectly applicable to the oriented gold nanorod colloidal crystals.",Prion Detection Through Organized Arrays of Gold Nanorods as SERS Substrates,FP7,31 March 2016,01 April 2014,230036.0 PROARGUS,International Centre of Biodynamics * Centrul International de Biodinamica,health,"Proteins aggregates are supramolecular ensembles capable to elicit significant biological responses and alter molecular reactions and quantitative, high throughput monitoring of the aggregation process is needed in high impact fields such as pharmacy and medicine. Very recent results show the possibility of ultrasensitive and conformation specific detection of proteins using sensors with Molecular Imprinted Polymers (MIP's). Formed in the presence of target analyte, these polymers retain the memory of analyte's shape. We propose to take advantage of the heightened and specific recognition properties of MIP's to build an integrated sensing platform for the simultaneous, specific detection of monomer, dimer and a higher protein aggregate. This device will circumvent the need for prior separation of protein species and will be employed to monitor the aggregation of two proteins, lyzosyme and calcitonin. The innovative platform we envisage consists in nanoarrays with layers of MIP's specific for monomer, dimer and a higher aggregate, deposited on the tips of gold nanopillars. Detection is based on the principle of impedance restoration when the 'holes' in the polymer layer are filled by target protein species. Very sensitive detection of lyzosyme and calcitonin is anticipated and feasability of MIP micro arrays for monitoring the aggregation process will be assessed through a forced protein degradation study and rigorous validation against a reference method. The project takes a multidisciplinary approach to shed light on the kinetics of orientation of protein species at MIP 'holes' and investigate non-specific adsorption, with additional knowledge to be gained through Atomic Force Microscopy, Electrochemical Methods and Surface Plasmon Resonance studies using state-of-the-art equipment available at host institution. Many answers to questions regarding aggregates themselves, their differences in shape and properties are expected to be provided in this way",Protein Aggregation - a quantitative assessment,FP7,28 February 2015,01 March 2011,100000.0 PROBI,London School of Economics and Political Science,health,"Biomaterials are revolutionising many aspects of preventive and therapeutic healthcare. They are already playing an important role in the development of new medical devices, prostheses, tissue repair and replacement technologies. This proposal addresses two of the most critical issues in biomaterials research: lack of knowledge of the fundamentals processes underlying interfacial interactions and bacterial infection. We will focus our research on materials used for ophthalmological implants and in particular on the ones used in the manufacturing of intra-ocular lenses for cataract surgery. We will study the interaction of Staphilococcus epidermidis with biomaterial surfaces with nanoscience techniques. Staphilococcus epidermidis ranks first among the causative agents of nosocomial infections. In particular, S. epidermidis represents the most common source of infections on indwelling medical devices. Based on the knowledge accumulated in recent years about the characteristics that make a successful biocompatible interface we propose to research on the properties of amphipatic fungal proteins Hydrophobins as a plausible candidate to modulate the biomaterial interface. In particular, we will investigate class I hydrophobin extracted from the basidiomycete fungus Pleurotus ostreatus, whose properties are only partially investigated. Several studies have shown that class I hydrophobins do not seem to be toxic or cytotoxic or immunogenic, thus they are susceptible to be used in various medical and technical applications. We propose to coat model surfaces with thin layers of native hydrophobin. The adhesion properties of the layer to the substrate as well as the wetting properties of the biofilm surfaces, will be fully investigated. Subsequently interaction of bacteria with hydrophobin coated surfaces will be investigated. The goal is to obtain information about the factors that may reduce the incidence of infections due to bacterial colonization on biomaterials.",PRotein cOatings to prevent Bacterial Infections,FP7,11 September 2012,12 September 2011,117213.0 PROETEX,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"ProeTEX will develop integrated smart wearables for emergency disaster intervention personnel, improving their safety, coordination and efficiency and for injured civilians, optimising their survival management. This core application area, which is of significant societal importance in itself, will drive a wide range of key technology developments, building on current and past EU and national projects and the commercial activities of partners, to create micro-nano-engineering smart textile systems - integrated systems (fabrics, wearable garments) using specifically fibre-based micronano technologies. These are capable of being combined into diverse products addressing this core application area but also a wide range of other markets from extreme sports, through healthcare to transportation maintenance and building workers. The industrial partners can address these markets. Fiber systems can integrate sensors, actuators, conductors, power management, and the emergency disaster personnel smart garment will, within a wireless ambient planning and managing environment, progressively enhance and integrate fiber systems for: * continuous monitoring of life signs (biopotentials, breathing movement, cardiac sounds) * continuous monitoring biosensors (sweat, dehydration, electrolytes, stress indicators) * pose and activity monitoring, * low power local wireless communications, including integrated fiber antennae * active visibility enhancement, light emitting fibers * internal temperature monitoring using fiber sensors * external chemical detection, including toxic gases and vapours * power generation - photovoltaic and thermoelectric and power storage. The technological base developed will concentrate on smart fibers/e-textiles, but the IP will combine these where appropriate with `conventional' microsystems (such as accelerometers, gyros, microcontrollers and wireless chips).",Protection e-Textiles: MicroNanoStructured fibre systems for Emergency-Disaster Wear,FP6,31 July 2010,31 January 2006,8100000.0 PROFI,Universiteit Utrecht * Utrecht University,information and communications technology,"In this project we aim to invent and develop new techniques for the retrieval of figurative images (such as clip art, logos, signs) from large databases. Our techniques will be based on the extraction and matching of perceptually relevant shape features, thereby overcoming many of the limitations of existing methods. This project will develop and evaluate new algorithms for:� Perceptual segmentation of raw images, and grouping of shape elements.� Matching of geometrical patterns representing shape features.� Partial matching: fitting part of one shape with part of another.� Indexing shape features in huge databases of figurative images.� Indexing the relative spatial layout of shape features within these images.The project meets the objectives of the FET programme through a highly innovative (and hence high-risk) programme to develop novel techniques for shape matching aimed at tackling one of the key problems limiting the effectiveness of current image retrieval techniques. Our project offers the possibility of significant advances at both the scientific and economic level. New in our approach is the primary role of perceptually relevant shape features, the emphasis on the unsolved problem of partial matching, and indexing over lay-out and shapes rather than over feature vectors. The newly developed algorithms will be experimentally verified in a prototype system, and subjected to rigorous evaluation on databases with independently-validated ground truth.We consider that the Profi project meets the objectives of FET Open. Specifically: � The proposed research is inherently innovative, high-risk and long-term.� It is embryonic research, showing proof-of concept.� It holds out the promise of major advances at a foundational level.",Perceptually-relevant Retrieval Of Figurative Images,FP6,29 February 2008,29 December 2004,997000.0 PROFORM,Fundación LABEIN,transport,"European Automotive industry constitutes one of the largest and dominant industries worldwide. In order to preserve its competitiveness and to give response to the rising legislative, political, social and market demands, the car makers are forced to: - Reduce manufacturing production cost - Short the product development times - Meet customer demands - Improve fuel economy and reduce pollution Compounding those challenges is an effort to reduce the delivery lead times associated with producing a built to order vehicle. The key factor to success lies in a cluster strategy that integrates the suppliers in the search and implementation of new solutions. As a consequence the players at the production level are compelled to build up cost effective and flexible processes able to meet customer demands and to short the product cycle. PROFORM is a research project that brings car manufacturers, component, tooling and equipment suppliers together with universities and research institutes for a new engineering and manufacture concept development, based in built to order system for reducing lead time and costs in producing high technology transport components for vehicle bodies The breakthough concept is based on the integration of three emerging forming technologies (roll forming RF, laser forming LF and electromagnetic forming EMF) in the frame of a simultaneous engineering and production strategy and exploiting the new capabilities in the area of new and multifunctional materials: - Micro technologies for rolls control to allow the production of complex components by RF - Ultra conductor coils and nano-reinforced resins to increase EMF efficiency - Coating/film/laminate steel to allow the production of multifunctional steel complex shape by EMF The project has a S&T multi-disciplinary nature, combining the three forming technologies with multifunctional materials, nano and micro technologies and using process simulation, optimisation and control technologi",An innovative manufacture process concept for a flexible and cost effective production of the vehicle body in white: Profile Forming,FP6,31 October 2010,01 November 2006,5993000.0 PROGRAM-NANO,Autonomous University of Madrid * Universidad Autónoma de Madrid,energy,"'Program-Nano' aims at establishing unconventional and versatile strategies towards organic architectures whose size, composition, internal structure, and function can be rationally predesigned and controlled. In a bio-inspired manner, we will 'program' functional molecules with the required information to self-assemble into unique, well-defined nanofibers or nanotubes. We want to focus on two main ambitious objectives for the application of such organic nanostructured materials. 1) The design and preparation of optoelectronic devices, such as plastic solar cells, where nanostructured fibers are integrated within the active layers. The major goal is to determine the influence of the molecular organization and the morphology at the nanoscale on the performance of the device, and to try in this way to set new records in device efficiency. 2) The fabrication of plastic nanoporous materials for the separation, storage or catalytic transformation of (bio)molecules in which the size, the shape ratio, and the internal functionalization of the nanopores can be custom-tailored.",Programmed Nanostructuration of Organic Materials,FP7,31 October 2016,01 November 2011,1300932.0 PROMENADE,Silvaco Data Systems Europe,information and communications technology,"Although the margin with regard to other parts of the world is getting smaller, European microsystem technologyis still leading and is one of the future economic domains with great potential and impact on almost all areas oftechnological development. A major reason for this success is the large variety of different microsystem processtechnologies as most of the target devices such as MEMS and MOEMS require an application specificfabrication process. To keep and to extend the margin of European microsystem technology the PROMENADEproject adds to reproducibility, manageability and time to market issues related to the maintenance ofmicrosystem processes.Today technology information derived from simulation, tests or measurements is usually kept informally and non-systematically on paper, in Excel sheets or merely in the heads of process engineers and is hence hardlyaccessible for use in future process development projects.The objectives of the PROMENADE project are to realise a computer-based environment supporting processengineers in creating, verifying, simulating, optimising and maintaining thin film Si processes with predictablecharacteristics as well as designers of micro devices by offering them a formal interface to constraints from thetechnological domain and facilitating design for manufacturing. Special attention will be paid to respect IPRprotection issues of users / partners and company specific IPR protection.A major part of the effort will be related to the generation of the simulation environment, implementing thedeveloped empirical and physical models generated by the detailed physical study. Single process stepsimulations and characterisations as well as simulations of complete process sequences will be available toderive rules forming the foundation for process validation as well as process assessment.The system is founded on a common database, industry leading TCAD (Technology CAD) tools and text truncated for the purposes of the ES",Process management and design system for microsystem technologies,FP6,31 March 2007,31 December 2003,3000000.0 PROMET,University of Bern * Universität Bern,health,"In the European Union ~200.000 men are diagnosed with prostate cancer every year and that number is likely to increase due to the aging population. Because of the progress made in the treatment of the primary tumor, mortality is increasingly linked to metastatic disease, often occult (= micrometastasis or minimal residual disease) at the time of diagnosis/therapy of the primary tumor. Understanding the complex mechanisms of metastasis (circulating tumor cells - micrometastasis - metastasis) at the molecular and physiological level is crucial for successful detection of minimal residual disease and for evolving possible strategies for the prevention of their development into overt metastasis. In this project we propose to elucidate the mechanisms and the signature of minimal residual disease in prostate cancer and to develop novel therapeutic approaches to prevent the development of minimal residual disease to overt metastasis. In close collaboration of basic scientists with clinical researchers the pathways of minimal residual disease will be explored using functional genomics and expression profiling as technology platforms, advanced experimental models of minimal residual disease using bioluminescence, multiphoton microscopy, nanotechnology and optoacoustic technology for detection and treatment. Innovative imaging and therapeutic strategies developed by the industry and selected for their potential to enhance detection and eradicate minimal residual disease will be tested in preclinical models for subsequent clinical evaluation. The goal is to identify at least 2 signal transduction targets and to develop a diagnostic test for the detection of thepresence of minimal residual disease and to define a novel therapeutic strategy for the treatment of this disease in prostate cancer. Thus, earlier detection and disease-specific treatment may decrease morbidity and mortality and ultimately have an impact on socio-economical costs.",Prostate cancer molecular-oriented detection and treatment of minimal residual disease,FP6,30 September 2010,01 April 2006,4034200.0 PROMETHEUS,University of Bologna * Alma Mater Studiorum Università di Bologna,manufacturing,"The precipitation of alkaline-earth carbonates in silica-rich alkaline solutions yields nanocrystalline aggregates that develop non-crystallographic morphologies. These purely inorganic hierarchical materials, discovered by the IP of this project, form under geochemically plausible conditions and closely resemble typical biologically induced mineral textures and shapes, thus the name ‘biomorphs’. The existence of silica biomorphs has questioned the use morphology as an unambiguous criterion for detection of primitive life remnants. Beyond applications, the study of silica biomorphs has revealed a totally new morphogenetic mechanism capable of creating crystalline materials with positive or negative constant curvature and biomineral-like textures which lead to the design of new pathways towards concerted morphogenesis and bottom-up self-assembly created by a self-triggered chemical coupling mechanism. The potential interest of these fascinating structures in Earth Sciences has never been explored mostly because of their complexity and multidisciplinary nature. PROMETHEUS proposes an in depth investigation of the nature of mineral structures such as silica biomorphs and chemical gardens, and the role of mineral self-organization in extreme alkaline geological environments. The results will impact current understanding of the early geological and biological history of Earth by pushing forward the unexplored field of inorganic biomimetic pattern formation. PROMETHEUS will provide this discipline with much needed theoretical and experimental foundations for its quantitative application to Earth Sciences. The ambitious research program in PROMETHEUS will require the development of high-end methods and instruments for the non-intrusive in-situ characterization of geochemically important variables, including pH mapping with microscopic resolution, time resolved imaging of concentration gradients, microscopic fluid dynamics, and characterization of ultraslow growth rates.",Pattern formation and mineral self-organization in highly alkaline natural environments,FP7,07 July 2021,08 January 2014,2431771.0 PROMINAS - 06,Technion Israel Institute of Technology,photonics,"The proposed 6 short training courses and the final workshop, offered in this series of events, are all related to the microelectronic manufacturing and the interdisciplinary aspect of the transition from the 'conventional' microfabrication methods (Clean Rooms) to the new environments that will incorporate novel materials and methods under development by various nanotechnologies. Trainees will be exposed to the required theoretical background, and get a direct hands-on experience in different aspects of micro and nano fabrication. The proposed series of events will cover the 'conventional' approach and extend into the various interdisciplinary aspects of nanotechnologies. The courses will illuminate the need for integration of the procedures, and thus lead to a significant step in educating scientists for work in a future nanoelectronic fab in Europe. It should be noted that the materials, methods, and equipment commonly used in nanotechnology are not always compatible with the conventional microelectronic manufacturing in 'clean room environments', and not necessary scalable to circuits comparable to present VLSI electronics. This series of events will address these issues. All that will be emphasized in the following 2 week courses: 1. Basic Microelectronic processing; 2. Organic polymer electro-optic nano-devices; 3. e-beam based tools for device/materials characterization (FIB-TEM); 4. Growth and structural characterization of semiconductor nanostructures (MBE); 5. Single electron transistors, Photonic Crystals and nano-tools; 6. Electrical and optical characterization of nanodevices. The courses will be followed by a 3 days workshop (conference type) on the convergence of conventional microelectronics and nanotechnology.",Prototyping in the Micro and Nano Scale 2006,FP6,31 December 2009,01 January 2007,647521.21 PROMINE,Geological Survey of Finland * Geologian Tutkimuskeskus,environment,"The objectives of the ProMine IP address the Commission’s concerns over the annual 11 billion € trade deficit in metal and mineral imports. Europe has to enhance the efficiency of its overall production chain putting higher quality and added value products on the market. ProMine focuses on two parts of this chain, targeting extractive and end-user industries. Upstream, the first ever Pan-EU GIS based mineral resource and advanced modelling system for the extractive industry will be created, showing known and predicted, metallic and non-metallic mineral occurrences across the EU. Detailed 4D computer models will be produced for four metalliferous regions. Upstream work will also include demonstrating the reliability of new (Bio)technologies for an ecoefficient production of strategic metals, driven by the creation of on-site added value and the identification of specific needs of potential end-users. Downstream, a new strategy will be developed for the European extractive industry which looks not only at increasing production but also at delivering high value, tailored nano-products which will form the new raw materials for the manufacturing industry. ProMine research will focus on five nano-products, (Conductive metal (Cu, Ag, Au) fibres, rhenium and rhenium alloy powders, nano-silica, iron oxyhydroxysulphate and new nano-particle based coatings for printing paper), which will have a major impact on the economic viability of the extractive industry. They will be tested at bench scale, and a number selected for development to pilot scale where larger samples can be provided for characterisation and testing by end-user industries. It will include production, testing and evaluation of these materials, with economic evaluation, life cycle cost analysis, and environmental sustainability. ProMine with 26 partners from 11 EU member states, has a strong industrial involvement while knowledge exploitation will transfer ProMine results to the industrial community.",Nano-particle products from new mineral resources in Europe,FP7,04 June 2015,05 January 2009,1.0999664E7 PROMINENT,Okmetic Oyj,information and communications technology,"Prominent aims to incorporate inkjet printing as a part of the MEMS fabrication process. By using maskless, digitally controlled, localized additive processes instead of the subtractive processes used currently, selected steps in the MEMS manufacturing can be done with simplified process sequence. This will result in",Processes for MEMS by inkjet enhanced technologies,FP7,02 May 2018,03 January 2013,0.0 PROMISING,IMEP-LAHC Laboratory,health,"Atomic Force Microscope (AFM) is now a common tool for material analysis in both academic and industrial areas because it enables non-destructive high resolution images of nanometric objects. However, the available sensors face strong limitations in liquids, making the use of AFM on living material like proteins or cells still a challenge. Thanks to our breakthroughs in MEMS sensors technology, we propose to extend the AFM potential to in vitro imaging of biological objects. Targeting beyond the academic applications, our goal is to establish a marketable force imaging technique for creating and addressing new instrumentation markets from biology and life sciences to medical analysis. The proof of concept will focus on building a dedicated microscope employing our microsystems probes for demonstrating high performance, user-friendly bio-imaging. The objectives of the present proposal are threefold: (i) verifying the innovation potential of the idea arising from the ERC Starting Grant Project 'SMART' by pushing a new instrument to a pre-demonstration stage of commercialization, (ii) establishing the viability of the concept and the near term market potential, (iii) clarifying IPR position and market launch strategy. Expected outcomes lie in the consolidation of information and data making possible to take strategic decisions and to put together a reasonable and acceptable development plan.",HIGH PERFORMANCE ATOMIC FORCE MICROSCOPE FOR IN VITRO BIO-IMAGING,FP7,28 February 2013,01 March 2012,144926.0 PRONANO,NanoWorld Services GmbH,information and communications technology,"Scanning proximity probes (SPP) are uniquely powerful tools for analysis, manipulation and bottom-up synthesis: they are capable of addressing and engineering surfaces at the atomic level and are the key to unlocking the full potential of Nanotechnology. Current SPP nanotools are limited to single probes with pitifully slow processing rates and, even at the research level, attempts at multiprobe systems have achieved only a 32x32 array. This could be a terminal limitation for the future of Nanotechnology, in particular for bottom-up manufacturing, with little prospect for economic throughputs, unless 2-dim. massively parallel probe arrays can be realised. Such a development would revolutionise Nanotechnology, triggering an avalanche of new products and processes in a wide range of applications including surface chemistry, materials and the life-health industries. This ground-breaking technology development is the ambitious principal aim of this proposal. Generic massively parallel intelligent cantilever-probe platforms will be produced through a number of techniques. The ultimate product will be, packaged VLSI NEMS-chip incorporating 128x128 proximal probes, fully addressable with control and readout interconnects and advanced software. To validate this novel technology, a series of demonstrations are planned where relevant SMEs will use this technology to carry out sub-10 nm metrology for high throughput manufacturing. Furthermore selected key applications and the results will be used to educate and inform in support of the development of new nanotechnology processes and products. It is the aim of PRONANO that the new massively parallel SPP nanotools with VLSI ASNEMS chips inside should empower nanotechnologists and drive the rapid development of nanoscience, leading to new nanotechnology processes and their industrial exploitation. They will secure the future of nanotechnology with economic throughputs leading to new manufacturing industries.",Technology for the Production of Massively Parallel Intelligent Cantilever - Probe Platforms for Nanoscale Analysis and Synthesis,FP6,30 September 2010,01 April 2005,8500000.02 PROPAGATE,Scientific Computing & Modelling N.V.,energy,"A leading European scientific software company (SCM), a research group of a private university (JacobsUni) and an associated research group with long-term history in collaborating with the industry partner (VU Amsterdam), want to collaborate in the development of advanced methods for first principles atomistic computer simulations and their application on environmentally important topics of nanotechnology and biophysics. Three ESR will develop methods allowing efficient first-principles molecular dynamics studies of the ground state, of thermally excited as well as of photo-excited states, and extended simulations using hybrid methods combining quantum mechanics with classical mechanics. The methods will be used for two applications in the fields of nanotechnology and biophysics, namely to study the high-temperature formation, solubility of mixed metal oxide heteroparticles that are interesting materials for the photoelectrolytic water splitting, the dynamics of the photo-excited states in these systems, and to investigate the signal transduction in light-sensitive proteins. The fellows will be trained in technical, industry, academic and transferable skills, all of them necessary for this intersectoral and supra-disciplinary project. PROPAGATE will be supported by an ongoing MC-IAPP scheme between JacobsUni and SCM and by a starting MC-IRSES project coordinated by JacobsUni.",New Propagation Techniques for the simulation of dynamical processes in extended systems,FP7,31 October 2016,01 November 2012,693388.0 PROSUITE,Universiteit Utrecht * Utrecht University,environment,"The main goal of PROSUITE is to develop a framework methodology, operational methods and tools for the sustainability assessment of current and future technologies over their life cycle, applicable to different stages of maturity. The project will apply the methodology for four technology cases with close consultation of the stakeholders involved, which includes cases from biorefineries, nanotechnology, information technologies, and carbon storage and sequestration. PROSUITE will show (i) how to combine technology forecasting methods with life cycle approaches, and (ii) how to develop and possibly combine the economic, environmental and social sustainability dimensions in a standardized, comprehensive, and broadly accepted way. PROSUITE will create a solid research basis for technology characterization, including the identification of decisive technology features, basic engineering modules for estimations of material flows and energy use, and learning curves. For the economic assessment, methods for the assessment for economic and sectoral impacts of novel technologies will be developed and combined with background data for scenario-based life-cycle inventory modelling. For the environmental assessment, state-of-the-art environment indicators will be proposed together with targeted method development for the assessment of geographically explicit land and water use impacts, metal toxicity and outdoor nanoparticle exposure. For the social assessment, a set of quantitative and qualitative social indicators will be selected via participatory approaches, setting the standard for future assessments. The use of various multicriteria assessment methods will be explored to aggegrate across indicators. The methods developed will be part of a decision support system, which will be output as open source modular software.",Development and application of standardized methodology for the PROspective SUstaInability assessment of TEchnologies,FP7,10 July 2015,11 January 2009,4782196.0 PROSURF,University of Modena and Reggio Emilia * Università degli Studi di Modena e Reggio Emilia,health,"Recent combinatorial biotechnologies have shown that the molecular recognition capability of proteins can be specifically oriented toward inorganic surfaces. The use of technologies based on such specificity would give European industry a competitive edge in several emerging fields (from nanoelectronics over biomaterials science to drug design), spanning different thematic areas of FP6. However, at present the principles regulating protein-surface interactions are poorly understood, thus hindering such technologies from taking off. What features of the surface and of the proteins (electronic, structural, morphological) determine which protein is able to bind to a given surface and how? PROSURF will answer this question and provide the European scientific/technological community with computational tools to enable rational design of protein-surface associations. As automated in silico docking revolutionized the process of drug discovery, so the outcomes of PROSURF will open genuinely new routes to solve several urgent technological problems, such as self-assembly of nanoelectronic devices or design of highly biocompatible materials. PROSURF is risky because it addresses a largely unexplored subject; however, the risk is compensated by the potential of enormous impact. Our strategy to probe the determinants of protein-surface specificity, and to implement the envisaged computational tools, integrates state-of-the-art computational techniques and experiments. It consists of a series of computational steps, including quantum-mechanics based parameterisation of protein-surface interactions, molecular dynamics simulation of proteins on surfaces, and the implementation of protein-surface docking software, corroborated by tailored experiments. Although the project focus is on theory, feedback from experiments will be important both to validate the computational tools, and to gain new insight into the basis of protein-surface interactions.",Computational toolbox for protein surface docking,FP6,31 December 2009,01 September 2006,1000000.0 PROTCAGE,Universiteit Twente * Twente University,health,"Protein cages appear to be common structures in biology, found in viruses but also in organelle-like containers discovered in bacteria. In this proposed program I aim to study chemical processes in nano-sized protein cages as mimics of bacterial organelles and to increase the general understanding of chemistry in confinement. Towards this goal we will investigate the controlled in vivo loading of bacterial protein cages, i.e. encapsulins, with proteins and enzymes. This will allow us to study in detail the chemical conversions that take place inside such capsules and it will increase understanding about the reasons why certain processes inside these simple organisms are encased in the protein organelles. Completely artificial protein organelles will be constructed by in vitro processes using the well-studied Cowpea Chlorotic Mottle virus cage. By employing DNA technology, cages will be loaded with a single enzyme, a sequence of enzymes or molecular probes. By obtaining this high level of control, we can not only study chemical conversions on the inside, but it will also allow us to monitor the physiochemical properties, such as internal pH, polarity and porosity of the protein mantle by encasing the relevant probes or host/guest systems. In the ultimate stage of the proposed project the formed artificial organelles will be brought into cells in order to interact with the cell metabolism. CCMV has to be introduced by surface modification, while encapsulins can be formed inside these cells; albeit with different cargo. Such experiments have, to my knowledge, not been carried out and introducing new reactions inside these organisms can lead to new potentially interesting products or interfere with cell vitality. The latter can be of importance for the controlled disruption of bacterial cells.",Chemistry in the Confinement of Protein Cages,FP7,30 April 2019,01 May 2014,1994400.0 PROTEINLED,Ozyegin University * Özyeğin Üniversitesi,health,"Green photonics aims to provide solutions that generate or save energy, reduce pollution and greenhouse gas emissions, produce environmentally sustainable outputs or enhance public health. Solid-state lighting (SSL), one of the most important green photonics technologies, offers 50% reduction in global electricity consumption for lighting that corresponds to the production by hundreds of coal plants and decrease in millions of tons of carbon emission, if the entire conventional white light sources are to be replaced with energy-efficient light emitting diodes (LEDs). However, the widely used phosphor-based white LED technology and the currently investigated nanocrystal-based white LEDs have limitations in terms of biocompatibility, energy efficiency and color quality. To this end, we propose a new class of color-conversion LEDs integrated with proteins to overcome the disadvantages of currently used and investigated color conversion materials. For this, we will work on the theoretical modeling, design, fabrication and experimental realization of these new solid-state lighting devices. The excellent optical properties of the fluorescent proteins including strong absorption, high fluorescence quantum yields and high photostability will enable us to achieve efficient and stable white light generation. Furthermore, the biocompatible characteristics of the proteins have the potential to minimize the pollution caused by the color-conversion materials and make them a strong candidate for 'green lighting'. These hybrid photonic devices will embody fluorescent and transparent silk-fibroin proteins on III-V InGaN/GaN light-emitting structures. This project aims for protein-integrated color-conversion white LEDs that are expected to simultaneously achieve high-quality, efficient and eco-friendly solid-state lighting. Therefore, this project offers a potential solution to help addressing economical and environmental challenges we are now facing due to the energy problem.","Protein-integrated white light-emitting diodes for efficient, high-quality and biocompatible solid-state lighting",FP7,28 February 2017,01 March 2014,75000.0 PROTEPROBE,National School of Mining of Saint-Etienne * École nationale supérieure des mines de Saint-Étienne,health,"ProtEprobe takes advantage of the recent cutting edge developments in protein conformation control at the Malliaras group and high sensitive protein sensing using high sensitivity factor triangular silver nanoplates by the fellow. Misfolding of a protein occurs when it becomes trapped in a local potential energy minimum where the conformation differs from the native-state structure. External electric fields have been demonstrated to distinctly alter protein secondary structures. Proteins associated with protein misfolding diseases, incuding neurodegenerative diseases such as Alzheimer's, undergo conformational changes such as the transformation of largely random coiled or α-helix structures to the highly ordered β-structures found in protein fibrils. Amyloid fibrils formed from peptide Amyloid beta (Aβ), are a major component of amyloid plaques in the brains of Alzheimer's patients. The ProtEprobe technique will use electrical potential gradients to stimulate and control the conformation transitions of proteins including the cell adhesion protein Fibronectin and Aβ on 3D electrospun conductive polymer tissue scaffolds. The high sensitive spectral response of the nanoplate monitors will be used to analyse protein conformational transitions and observe the progression of Aβ fibril formation. Investigations will be carried out to ascertain the impact of the presence of an electric field and the capacity to tune the strength in order to enable improved understanding and selection of protein conformations on tissue scaffolds, towards enhancing cell surface interactions, healing of misfolding and facilitating the restoration of the structure and function of diseased tissues. In a paradigm step towards imparting a new dimension to tissue regeneration, ProtEprobe will develop 3D bioactive scaffolds with electrically programmable protein conformation and in situ real-time protein nanomonitors paving the way for the treatment and prevention of many neurodegenerative diseases.",Electrically Controlled Protein Conformation on 3D Tissue Scaffolds,FP7,30 October 2015,01 May 2013,269743.0 PSMS-IN-INFLAMMATION,UNIVERSITAIR MEDISCH CENTRUM UTRECHT * UNIVERSITY MEDICAL CENTER UTRECHT,health,"Staphylococcus aureus community-acquired (CA)-MRSA strains are highly virulent and can cause infections in otherwise healthy individuals and are a leading cause of death worldwide. Innate immunity is our primary defense against invading staphylococci. Blood-neutrophils migrate to the site of infection where they, in concert with the complement system, engulf and kill bacteria in a process called phagocytosis. Especially CA-MRSA strains seem to be very efficient in circumventing this neutrophil killing. Interestingly, only a relative small number of virulence factors have been associated with CA-MRSA, one of which are the phenol soluble modulins (PSMs). In vivo models of experimental infection with PSM-mutants have shown a critical role for PSMs in skin and soft tissue infections. PSMs are small alpha-helical peptides which have two distinct functions on the immune system, in vitro PSMs can attract neutrophils in the nanomolar range, whereas in the micromolar range they are cytolytic for neutrophils. Recent publications suggests that these two functions complement each other for full staphylococcal virulence, although it seems counter-intuitive for S. aureus to actively attract its mortal enemy: the neutrophil. To make matters even more complicated PSMs are functionally inactivated by host serum lipoproteins, most efficiently by high density lipoprotein (HDL). The goal of this research proposal is to determine the mechanism of action for PSMs in staphylococcal disease. To this end, I will use genomic and proteomic approaches combined with cutting edge in vivo spinning-disk confocal microscopy, to dissect the functions of PSMs in host-staphylococcal interactions in; 1) neutrophil recruitment, 2) neutrophil lysis 3) HDL neutralization and liver pathology, 4) Evasion of PSM-recognition by FLIPR-L",Imaging Innate Immunity of Staphylococcal Infections,FP7,08 April 2017,09 April 2014,259582.0 PSY-NANO-SI,Polytechnic University of Valencia * Universitat Politècnica de València,health,"The project joins together two most common and apparently well-studied elements on the Earth - silicon and oxygen. Both are most important for human life: oxygen mediates biochemical reactions while silicon is the most important technological material. The project claims to explore a new type of interaction among these elements, though in their artificially created forms (silicon converted into nano-Si - with small Si clusters connected into highly porous network, and oxygen excited into highly reactive singlet state). Project will address fundamental issues of physics (optics of nano-structured semiconductors, energy transfer between molecules), chemistry (photo-chemical reactions mediated by singlet oxygen with molecules, e lectrochemistry of porous semiconductors, surface reactions), biology (photo-oxidation of bio-molecules) and medicine ( photo-stimulated apoptosis of living cells). Therefore, it will contribute to the advancement in these fields of science and will ensure continuous break-through innovations in important issues of human well-being. Technological frontiers to explore are application of highly reactive singlet form of oxygen molecule generated by nano-Si in a variety of fields vital for the improvement of human life: curing of severe diseases, fine organic synthesis, protection of environment. Specific Scientific and Technological Objectives of the project include: 1.Research and development of new process of singlet oxygen generation employing nano-Si as sensitizer; 2 Development of efficient and safe photo-sensitizers based on nano-Si; 3. Exploration of the possibilities to use nano-Si photo-sensitizers in Photo-dynamic therapy of cancer; 4. Application of nano-Si photo-sensitizers in organic synthesis and Biological applications Project explores two fundamental discoveries made by consortium members: generation of singlete oxygen by nano-Si and its biodegradability.",NANOSILICON-BASED PHOTOSYNTHESIS FOR CHEMICAL AND BIOMEDICAL APPLICATIONS,FP6,31 August 2008,01 March 2005,1650000.0 PULLNANO,STMicroelectronics SA,information and communications technology,"PULLNANO is a 30-month IP proposal for a powerful project focused on advanced RTD activities to push forward the limits of CMOS technologies. PULLNANO focuses on the development of 32 and 22nm CMOS technology nodes opening the way to the long term future of these technologies. The 1st objective of the project, to be achieved at t0+24, is the feasibility demonstration of 32nm node Front-End and Back-End process modules through a very aggressive SRAM chip and a multilevel metal stack structure. The 2nd objective is to realize research on the materials, devices, architectures, interconnects modeling and characterization to prepare the future 22nm node. For this purpose, PULLNANO incorporates an unprecedented number of Academic teams organized in clusters. The 3rd objective is to establish a common action between technology and design people in order to assess the technologies in terms of performances and power consumption. The 4th objective is to define, through a forum of European equipment suppliers, the specifications of future advanced process, characterization and metrology equipments. PULLNANO starts from the ongoing, very successful, NANOCMOS project focused on the 45nm technology. The original Consortium is enlarged to gather the best European competences in the domain. PULLNANO establishes close relation with the MEDEA+ programmes, where PULLNANO results are developed towards the industrial exploitation phase. This cooperation optimizes European funding while avoiding overlaps. PULLNANO adopts a professional management structure that deals with the complexity and ambitions of the project. PULLNANO is a reference project and a unique opportunity to increase the worldwide impact of European Nanoelectronics and create the conditions for future IST application.",PULLing the limits of NANOCmos electronics,FP6,31 December 2008,31 May 2006,2.5E7 PULMOSTENT,Aachen University Hospital * Universitätsklinikum Aachen,health,"Lung cancer is the most common cancer in terms of both incidence and mortality, worldwide. With a median age at diagnosis of 71, lung cancer is mainly affecting the aging population. Airway stenosis is a key problem with significant morbidity and premature death. Endobronchial stenting is a proven therapy to keep the airways open. Nevertheless the currently used clinical stents have major disadvantages either by rapid re-occlusion due to tumour ingrowths (metal stents) or massive mucus retention due to the interrupted mucociliary function (coated stents). The aim of the project is to develop a viable endobronchial stent (syn. PulmoStent) for the treatment of broncho-tracheal cancer diseases. The concept is based on the combination of stent technologies with the principles of tissue engineering. The PulmoStent is a multi-layered structure providing (1) a functional respiratory epithelium on the luminal side, which allows the maintenance of the mucociliary function in the stented area, (2) an embedded micro- or nanosphere formulations, enabling the sustained, local release of tumour-specific therapeutics in combination with (3) a mechanical separating layer on the external side, enabling a local tumour suppression to avoid stent displacement and restenosis by a growing tumour. The PulmoStent is a step change beyond the state-of-the-art from a passive to a viable and functional active implant tailored to the patient. It focuses on a clearly identified clinical need for the treatment of lung cancer. The combination of different kinds of biomaterials to a co-scaffold system for the bio-functionalization of the stent will lead to an improved performance of endobronchial stents and thereby to longer durability. The novel PulmoStent will improve the quality of life and increase the life expectancy of lung cancer patients, because of the reduced mucus retention in the stented area, and herewith the reduced risk of life-threatening pneumonia and the local tumour suppression.",Development & Evaluation of a Viable Stent Device for the Treatment of BronchoTracheal Cancer,FP7,31 March 2015,01 April 2012,3167699.0 PURSTEM,National University of Ireland Galway,health,"Stem cells offer a promising avenue to therapy for a wide range of complaints. However, for this potential to be realized, a consistent and plentiful supply of well-characterised stem cells is essential. There has been relatively little progress in the development of new culture technologies for the large-scale manufacture of mesenchymal stem cells (MSCs). There is a strong possibility that this limited ability to produce stem cells will result in delays to the translation of new therapies to the clinic. This will have a direct negative effect on the health of European citizens suffering from diseases untreatable by conventional medical technology and delay European efforts to promote 'NanoMedicine - Nanotechnology for Health'. PurStem will progress the state of the art in the production of mesenchymal stem cells (MSCs) in large quantities. The current state of the art has several weaknesses - there are no standards for characterisation, isolation or identification of MSCs from any tissue, nor are there standard protocols for differentiation of MSCs to various lineages. Additionally, surface markers used for MSC characterization lack specificity and cryopreservation protocols are not standardized. Critically, current production methods for MSC require the use of animal products with major contaminant implications. PurStem will • Identify the MSC 'receptome' and • Use this repertoire of growth factor receptors to • Develop novel serum-free media for MSC production. PurStem will also result in novel antibody reagents for specific MSC characterization and contribute to GMP manufacturing standards to enable rapid progression to production of serum-free MSC for clinical applications. The impact on a range of therapeutic and research domains of having a reliable supply of industrial levels of categorised MSCs will be significant. PurStem represents a key enabler for stem cell applications in a range of therapeutic fields.","Utilisation of the mesenchymal stem cell receptome for rational development of uniform, serum-free culture conditions and tools for cell characterization",FP7,30 April 2012,01 November 2008,2750367.0 Q-NET,Joseph Fourier University * Université Joseph Fourier,information and communications technology,"Q-NET will provide initial training in the general field of Quantum Nano-Electronics, in particular spintronics, molecular electronics, single-electronics, quantum dots and nanowires, nano-cooling. The recruited researchers will be trained to state-of-the-art technologies of nanofabrication, near-field microscopies, transport measurement under extreme conditions (low temperatures, magnetic field, radio-frequency irradiation) and theoretical calculations. Ultimate detectors, innovative local probes, new metrological standards, on chip micro-coolers will be developed. 25 key scientists from 8 different institutions will interact as a consistent training staff monitored by the supervisory board by reference to a 8-task detailed program. The 16 trained young researchers will be at the ESR level for 93%. The training will be implemented through systematic secondments of young researchers from one partner to several academic and private partners. The project website will be set-up to support the training strategy and the tracing of results and IPR. It will be animated by the recruited researchers under the supervision of the coordinator. Q-NET will organize sessions of the European School On Nanosciences and Nanotechnologies (ESONN) devoted to Quantum Nano-Electronics, combining both theoretical and practical training. Annual special training sessions will be organized, covering seven complementary domains such as ethics, project management, IPR, communication skills ... The consortium involves most of the leading groups in the domain which contributed these last ten years to the European leadership in Quantum Nano-Electronics. Q-NET will significantly contribute to meet the needs of the industry in terms of highly-skilled and open-minded scientists for leading the competition in “Beyond C-MOS“ Nano-Electronics.",Quantum Nano-Electronics Training,FP7,03 July 2017,04 January 2011,4022055.0 Q2M,Royal Institute of Technology * Kungliga Tekniska Högskolan,information and communications technology,"Integration of high-performance materials in microsystems (integrated electronics, systems, sensors and actuators) is limited by process incompatibility mainly (materials, temperature budget). Many technology combinations promising novel functionality in a large range of applications can therefore either not be realised today (e.g. high-performance sensors/actuators on CMOS), or are manufactured on a per-device level in a pick-and-place scheme with resulting high fabrication costs (e.g. microvalves), hindering such components from reaching the market and forcing industry to disregard the development of many novel devices. The main objective of Q2M is therefore to develop methods that allow the cost efficient combination and integration through batch-microfabrication of components and materials that are unsuited for monolithic integration. This allows novel functionality and reduced manufacturing costs. Two main strategies will be followed to push the technology beyond its current barriers. The first is the development of high quality actuator materials and their micromachining methods suited for wafer-scale fabrication. The second strategy is the development of transfer bonding methods for transferring materials and devices to semiconductor or polymer substrates. The development of both strategies will be guided by the specifications from three application areas: microvalving, micro-optics and RF-MEMS (radio frequency microelectronic components). Test structures will evaluate the developed techniques. The Consortium has six research focussed partners, each expert/pioneer in at least one core aspect of the multidisciplinary scientific challenge, and five application focussed partners (2 SMEs, 3 larger consortia), chosen to anchor the work in real industrial needs while creating the basis for further development and exploitation. Moreover, a Q2M User Group of interested companies is formed for technology spreading and exploitation outside the consortium.",Batch Integration of High-quality Materials to Microsystems,FP6,31 July 2009,31 January 2006,3200000.0 QB50,Von Karman Institute of Fluid Dynamics * Institut von Karman de Dynamique des Fluides,transport,The QB50 Project will demonstrate the possibility of launching a network of 50 CubeSats built by CubeSat teams all over the world to perform first-class science and in-orbit demonstration in the largely unexplored lower thermosphere. Space agencies are not pursuing a multi-spacecraft network for in-situ measurements in the lower thermosphere because the cost of a network of 50 satellites built,"An international network of 50 CubeSats for multi-point, in-situ measurements in the lower thermosphere and re-entry research",FP7,10 July 2017,11 January 2011,0.0 QC-LAB,Universiteit Leiden * Leiden University,information and communications technology,"The world of atoms is governed by the rules of quantum mechanics. Over the past century, quantum-mechanical phenomena such as superposition and entanglement have been observed and studied with great precision. Today, we are entering a new era in which we can hope to explore quantum mechanics in larger objects. The science of quantum mechanics in more complex objects is barely known and as a result quantum mechanics is rarely explicitly used in technology. Theoretically, superposition and entanglement could be exploited as a new resource in a wide variety of future applications. We focus on information science and investigate the use of quantum mechanics in computing, i.e. a quantum computer (QC). If information is encoded in quantum superpositions and processed by exploiting entanglement, a QC can solve computational problems that are beyond the reach of conventional computers. Building a QC is, however, an enormous scientific challenge because the fragile quantum bits need to be protected from and corrected for even the smallest disturbances by the environment. Meeting this challenge requires a synergetic effort combining the best of quantum theory, electrical engineering, materials science, applied physics and computer science. This proposal aims to achieve a robust, exemplary QC. We propose a circuit containing processor qubits (two types: superconducting transmon qubits and spin qubits in silicon quantum dots), memory qubits (two types: topological qubits with nanowires and donor qubits), and a quantum databus (superconducting striplines). Our goal is to demonstrate a 13-qubit circuit that incorporates fault-tolerance through implementation of a surface code. We will demonstrate back-and-forth quantum state transfer between processor and memory qubits. Our team brings together the required expertise into a single “QC-lab” enabling us to bring our understanding of quantum mechanics to the next level and push QC to the tipping point from science to engineering.",Quantum Computer Lab,FP7,10 July 2021,11 January 2013,1.5E7 QCCC,University of South Paris * Université Paris-Sud,information and communications technology,"'Quantum computation studies how information is encoded and processed in quantum mechanical systems. Its goal is to understand the inherent computational power of nature and although it is a rather new research area, there have already been numerous exciting results, including the algorithms for factoring and unconditionally secure key distribution. The study of the power and limitations of quantum computation is an interdisciplinary research area that lies on the boundary of computer science, physics, mathematics and brings together powerful theories and methodologies. Our scientific project will focus on the further study of quantum information and its numerous applications to classical computer science, communication and cryptography. Over the last couple of years the field of quantum information theory has developed increasing connections to other areas of theoretical computer science. Our result on Locally Decodable Codes was the first example of a classical result that uses quantum techniques in an essential way and since then, there has been an increasingly rich set of results that strengthens the relation between quantum and classical computation. We find these connections extremely promising and we would like to further investigate them. Second, we would like to continue investigating the relative power of classical and quantum information by looking at the model of communication complexity. Communication complexity has applications to VLSI circuits, data structures, automata and other areas of computer science and its study is essential towards a better understanding of the notion of information. The third axis of our research project concerns the area of quantum cryptography, which has been tested in practice very successfully. Our research goal is the study of theoretical quantum cryptography as well as collaborate with experimentalists on practical issues that arise in the laboratory.'","Quantum Information and Applications to communication, cryptography and classical computer science",FP6,02 May 2008,03 May 2006,80000.0 QCDOM,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,"Rapid progress in the field of optomechanics has undergone a paradigm shift in the last two years. It is now possible to use light to prepare and sense the quantum ground state of a nanomechanical oscillator. Alongside parallel developments in electromechanics, this success marks the emergence of a third wave of quantum technology based on mechanical systems, following in the footsteps of atomic physics in the 1970s and solid state spin ca. 10 years ago. The new field of quantum optomechanics faces key challenges on several fronts, including execution of protocols for preparation and readout of nontrivial quantum states, mitigation of fundamental sources of mechanical decoherence, and the search for robust and field-distributable architectures. The following proposal takes aim at this new threshold, exploring fundamental and practical aspects of coherence in a mechanical system optomechanically-cooled to near the quantum ground state. We build upon the capabilities of a state-of-the-art optomechanical system developed by the host group of T. J. Kippenberg at EPFL, consisting of a cryogenically-cooled silica microcavity with strongly coupled, high-Q optical and mechanical resonances. Using the recent development of quantum-coherent optomechanical coupling, we propose to demonstrate, for the first time, quantum-coherent state transfer of a nanomechanical resonator onto an optical field. Second, exploiting the tools of cryogenic optomechanics, we seek to observe and control *resonant* coupling of a micromechanical resonator to a two-level-fluctuator for the first time. Third, building upon developments in the integration of ultr-high-Q SiN nanobeams and Silica micro-disk resonators, we propose to realize a robust chipscale optomechanical system suitable for ground-state cooling using a simple table-top cryo-cooler.",Quantum Coherence and Decoherence in Cavity Optomechanics,FP7,11 June 2017,12 January 2013,0.0 QD-CQED,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"A quantum dot (QD) in a microcavity is an ideal single spin-single photon interface: the spin of a carrier trapped inside a QD can be used as a quantum bit and the coupling to photons can allow remote spin entanglement. A QD in a cavity can also generate single photons or entangled photon pairs, often referred to as flying quantum bit. Controlling the QD spontaneous emission is crucial to ensure optimal coupling of the photon and spin states. The present project relies on a unique and original technology we have developed which allows us to deterministically control the QD-cavity system. With this technique, we can fabricate a large number of identical coupled QD-cavity devices operating either in the weak or strong coupling regime. The potential of the technique has been proven by the fabrication of the brightest source of entangled photon pairs to date (Nature 2010). The objective of the present project is to build up a platform for basic quantum operations using QDs in cavities. The first aim is to develop highly efficient light emitting devices emitting indistinguishable single photons and entangled photon pairs. The mechanisms leading to quantum decoherence in QD based sources will be investigated. We will also explore a new generation of devices where QDs are coupled to plasmonic nano-antenna. The second objective is to implement basic quantum operations ranging from entanglement purification to quantum teleportation using QD based sources. The third objective of the project is to control the spin-photon interface. We first aim at demonstrating quantum non-demolition spin measurement through highly sensitive off-resonant Faraday rotation. We then aim at entangling two spins separated by macroscopic distances, using their controlled interaction with photons. This will be obtained either by making a single photon interact with two spin in cavities or by interfering indistinguishable photons emitted by two independent charged QDs.",A quantum dot in a cavity: A solid state platform for quantum operations,FP7,31 October 2016,01 November 2011,1482000.0 QDCN,ICN2 - Institut Català de Nanociència i Nanotecnologia,information and communications technology,"The aim of this project is to take advantage of the unique properties of carbon nanotubes (CNTs) for the fabrication of innovative nanoelectronic devices. The first nanodevice is a ultra-sensitive detector, designed to probe the electrical properties of individual molecules that are exposed to external perturbations, e.g. such as electric field or light. The detection scheme is based on an original approach, on the contrary to previous experiments which aimed at contacting individual organic molecules with two electrodes. With the two-electrode technique the problems have quickly appeared due to the poor control of the electrode/molecule interfaces. Here, the molecule is attached to only one electrode, a nanotube. The resistance of the nanotube is measured as a function of a gate voltage, which should be sensitive on the energy spectrum of the molecule. Low-current detection is expected to be particularly suitable for molecular electronics, since most of the molecular systems are highly resistive. This includes organic molecules, biological molecules, and semiconducting particles. Most importantly, such an approach is expected to be mostly independent on the quality of the molecule-nanotube interface, and in addition, it allows the device to be operational in higher temperature. The second proposed design of nanodevice is a non-volatile memory, which will be achieved also in one-electrode approach by combining a single nanoparticle (with diameters up to 10nm) with a carbon nanotube transistor. In the device, CNT acts as conduction channel and the charge stored in the nanoparticle behaves as a floating-gate. Charging effects will be obtained either from an atomic force microscope or directly from the nanotube. The objective will be to determine the operability of the device at room temperature and its limitation (necessary charge on floating-gate, temperature limitation).",Quantum Devices based on Carbon Nanotubes,FP7,06 December 2011,06 January 2010,159733.61 QDOTS,University of Cyprus,health,"The proposed research deals with the development of new imaging technologies with the use of semi-conductor and metal nanocrystals These new imaging technologies will continually be tested and used for the study of morphogenesis in Xenopus Laevis and other embryos. The primary goal of this project is to fully utilize the optical properties of QD;s for the study of biological processes. The study of morphogenetic movements in particular, is especially dependent on cutting edge imaging technologies, which in large part set the pace of discovery in the field. Our previous work includes the development of the first biocompatible Quantum Dots which were used for linage tracing and real time in vivo imaging of the development of Xenopus embryos. One of the first projects that we would pursue is the use of Near Infra Red QD;s for labeling and imaging of deep tissues within the Xenopus embryo. Current imaging technologies fail to provide visualization of deep tissue movements in vivo restricting our observation to the superficial layers and thus limiting our understanding. Development of deep tissue imaging will have several other applications, for example in non invasive diagnostic testing. A second objective would be the labeling of proteins with QD;s and investigating the effect of the label on a proteins function. We have successfully labeled actin monomers with QD;s and observed actin dynamics in vivo in Xenopus. We are planning to use Akt;s Plekstrin Homology domain labeled with QD;s as a biosensor to monitor the distribution of active Akt within migrating cells, in order to investigate its role in the migration of mesodermal cells. Preliminary results obtained using PH-GFP fusions suggest that Akt is involved but GFP fusions photobleach quickly and cannot be imaged in deep migrating tissues. It is expected that this IRG grant will help the principal investigator to establish a new research laboratory at Intercollege and help initiate his research activities.",Novel Quantum Dot Imaging technologies for the study of morphogenesis and other biological processes,FP6,30 September 2007,01 October 2005,80000.0 QDS,University of Santiago de Compostela * Universidade de Santiago de Compostela,health,"Quantum Dots (QDs) are a relative new semiconductor nanoparticles made from Cd/Se or Cd/Te with a shell of ZnS that have very excellent spectroscopic properties: broad absorption spectra, low photobleaching levels, narrow and symmetric emission bands, high quantum yields and large stoke shifts, which make them very attractive for fluorescence applications and, principally, for research studies in the biomedical field. The use of nanoparticles in vitro and in vivo has come in parallel with the development of water soluble QDs. However, together with the improvement in the solubility properties, there is a nascent necessity of developing efficient chemoselective methods of bioconjugation. This purpose is where is addressed this proposal to. We are going to try to use chemoselective ligations to attach peptides and proteins to QDs. In principle, we are interested in oxime, hydrazone reactions and [3+2] azide-alkyne cycloadditions, because it´s known that are very selective and happen with efficient rates at low µM concentrations (~10 µM) forming thermodynamically and kinetically stable products. Moreover, these ligation reactions have been used with success in peptide-peptide and peptide-dye conjugations. Once we have developed the conjugation methodology, we have in mind to apply it to the study of protein-nucleic acids and protein-protein interactions through the well-known FRET technique (Fluorescence Resonance Energy Transfer). We think that attaching a low number of proteins per quantum dot (around 5-10 protein molecules/QD) we can get high amplifications in the FRET signal, which will allow us to measure thermodynamic parameters like binding constants. To evaluate the method, we´ll study the system formed by GCN4 (a natural Transcription Factor) and its CRE recognition site (5´-…ATGACGTCAT…-3´), principally because there is a high literature data that help us to validate the approach.",New strategies for bioconjugation to quantum dots. Study of protein-nucleic acids and protein-protein interactions using fluorescence resonance energy transfer through quantum-dot-protein conjugates,FP7,30 September 2011,01 October 2008,225998.0 QICS,London School of Economics and Political Science,information and communications technology,"We seek to address two fundamental issues in Quantum Information and Computation (QIC), which we see as of key importance to its continued successful development. Firstly, we seek to gain a deeper insight into what Quantum Computation (QC) is in general, its structure, scope and limits, in the light of the recent development of several alternative formats for QC, in particular the measurement-based models. To this end, we will for example explore the axiomatic boundaries of QC, study QC resources and control structures, and aim to identify the essential ingredients reponsible for quantum algorithmic speed-up, with the ultimate aim of developing a convincing general model for QC. Secondly, we aim to develop high-level methods for QIC, adapting and extending the methods successfully used in classical computation, such as type systems, logics and calculi, and also the underlying mathematical structures such as categorical algebra. These high-level methods also have direct applications to QIC in their own right, e.g. for analyzing QCs with distributed resources, and in particular for the design and verification of secure quantum information protocols. These two aims are in fact inextricably inter-twined, since a deeper analysis of the fundamental concepts of QIC must go hand in hand with a sharper elucidation of its formal structure and logical content. Moreover, this research is inherently inter-disciplinary, drawing on insights and methods developed within both Computer Science and Quantum Physics. This is strongly reflected in our consortium, which includes leading figures in both disciplines. We aim to contribute to developing a common framework which brings the various communities together, establishing QIC as a systematic discipline in its own right. Our success would extend the leading European role in structure-oriented informatics research to the rapidly emerging field of QIC.",Foundational Structures for Quantum Information and Computation,FP6,30 June 2010,30 December 2006,1622500.0 QIPEST,London School of Economics and Political Science,photonics,"This early stage training network will provide doctoral training in the field of quantum computing and communication as well as in a variety of related quantum technologies. Research projects will be provided by leading UK research groups which collaborate via the nationwide Quantum Information Processing Interdisciplinary Research Collaboration (QIPIRC). Via the QIPIRC research is focussed on converting qubits between different physical systems like e.g. transferring photonic qubits into quantum dot qubits. The implementation of such basic quantum information processing tasks in physical systems like linear and nonlinear quantum optical systems, trapped neutral atoms and ions, semiconductor quantum dots and molecules inside carbon nanotubes greatly benefits from combining the strengths of physics groups in controlling the dynamics of quantum systems and the expertise of the material science groups in characterizing and modelling complex materials. The network will be embedded into the QIPIRC and several short term research projects and five full three year doctoral studentships will be offered. Short term studentships will be aimed at doctoral students in their second and third year. These students will immediately be fully integrated into current research activities of the QIPIRC and be working on projects which are related to their main area of study and will also be aimed at broadening the scope of their research. Furthermore they will have access to all skills training and postgraduate training courses. The three year students will undergo well structured research training where the first year includes postgraduate lectures, course work, skills training, careful planning of the research project, a research talk, and an oral viva. The second and third years concentrate on carrying out the research project, writing scientific publications in international refereed journals, giving presentations at conferences, further skills training and preparing the thesis.",Quantum information processing early stage training network,FP6,23 April 2010,24 April 2006,713870.24 QM,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),photonics,"Cavity optomechanics has over the past years emerged as a new research field in which basic concepts of quantum measurement theory such as quantum limited displacement sensing or backaction evading measurements as well as highly sensitive force measurements may be realized by virtue of radiation pressure optomechanical coupling to nano- and micro-mechanical oscillators. The objective of this research area is to achieve quantum limited detection of mechanical motion and ground state cooling of a mechanical oscillator. Analogous to the success of quantum limited photon detectors in the field of quantum optics, it is likely that quantum limited motion transducers will continue to lead to new advances in both fundamental science and technology. The significance of the research program lies in experimentally approaching the fundamental quantum limits of motion transduction and demonstrating quantum phenomena of a mechanical oscillator; the most tangible harmonic oscillator. This research will directly build on the recognized contributions of the participating Swiss research group, which is the Laboratoy of Photonics and Quantum Measurements of Dr. Tobias J. Kippenberg at the EPFL. The research group has over the past 4 years made many seminal and widely recognized contributions to the field of cavity optomechanics. The applicant is a French scientists who obtained his PhD at ENS in Paris in the labatory of the world renowned Quantum Physics pioneer Serge Haroche. His work has been pioneering and has been published in leading journals (including two publications in Nature). The proposed research activities are at the forefront of the rapidly developing field of cavity optomechanics - which has sparked widespread contemporary interest in Physics - , and will place the applicant in an excellent position to launch into a carreer in science. Moreover the applicant will be exposed within the Laboratory of Photonics and Quantum Measurements to complementary research projects.",Quantum Measurements and Ground State Cooling of Mechanical Oscillators,FP7,31 December 2011,01 March 2010,172565.0 QNANO,University College Dublin,health,"Nanoscale objects interact with living organisms in a fundamentally new manner, ensuring that a fruitful marriage of nanotechnology and biology will long outlast short term imperatives. Therefore, investment in an infrastructure to drive scientific knowledge of the highest quality will have both immediate benefits of supporting the safety assessment of legacy nanomaterials, as well as pointing towards future (safe) applications with the lasting benefits to society. There are immediate priorities, for few doubt that serious damage to confidence in nanotechnology, unless averted, could result in missed opportunities to benefit society for a generation, or more. QNano will materially affect the outcome, at this pivotal moment of nanotechnology implementation. The overall vision of QNano is the creation of a 'neutral' scientific & technical space in which all stakeholder groups can engage, develop, and share scientific best practice in the field. Initially it will harness resources from across Europe and develop efficient, transparent and effective processes. Thereby it will enable provision of services to its Users, and the broader community, all in the context of a best-practice ethos. This will encourage evidence-based dialogue to prosper between all stakeholders. However, QNano will also pro-actively seek to drive, develop and promote the highest quality research and practices via its JRA, NA and TA functions, with a global perspective and mode of implementation. QNano will also look to the future, beyond the current issues, and promote the growth and development of the science of nanoscale interactions with living organisms. By working with new and emerging scientific research communities from medicine, biology, energy, materials and others, it will seek to forge new directions leading to new (safe, responsible, economically viable) technologies for the benefit of European society.",A pan-European infrastructure for quality in nanomaterials safety testing,FP7,31 January 2015,01 February 2011,7000000.0 QNAO,IMEP-LAHC Laboratory,photonics,"The applicant has been recruited as a Chargé de Recherche for CNRS and will start soon at the Institut Néel (Grenoble, France) his own research activities. The Marie Curie Reintegration Grant will help him start his independent research career and support his installation at the Institute. The goal of the project is to extend the thematic of cavity optomechanics down to the nanoscale and observe the quantum first signatures with hybrid systems constituted of nanomechanical oscillators and single emitters. From their higher mechanical susceptibility, nano-resonators can facilitate the access to the quantum regime of radiation pressure and allow observing the week coupling to a single emitter. Those systems are also interesting candidates for opening links towards solid state physics at the condition to be able to detect and control their Brownian motion. The project will consist in developing an ultrasensitive nearfield sensor of the nanomotion. To do so the nano-mechanical oscillator will be approached in the evanescent tail of a high-Q optical microcavity, rendering its optical resonances sensitive to its position fluctuation. This approach allows to overpass the diffraction limit inherent to the use of light fields with sub-wavelength objects, while still benefiting from the ultrasensitive readout capacity offered by low noise laser sources. Various kinds of exotic resonators could then be studied, in particular suspended graphene membranes, nanotubes, and micropilars or photonic crystal cavities embedding single emitters. The second part of the project aims at studying the coupling of a nano-resonator to a single emitter (quantum dots / color center in diamond nano-crystals), a system that can be seen as a macroscopic trapped ion, and observes the first quantum signatures of this hybrid quantum system.",Quantum Nano Optomechanics,FP7,31 March 2013,01 April 2010,45000.0 QNEMS,Technische Universiteit Delft * Delft University of Technology,photonics,"In this project, we will investigate the quantum properties of nanoscale mechanical resonators. Suspended structures will be made of Al, SiN, GaAs, carbon nanotubes, and photonic crystals, covering frequencies in the MHz and GHz range. The vibrations will be excited by electrical means. To overcome the thermal noise, cooling of the low-frequency resonators will be performed. We will use two cooling techniques: sideband cooling due to the coupling to an electromagnetic resonator, and optical cooling. For the ultra-sensitive read-out of the displacement, optical methods will be used, as well as a novel technique based on incorporating the resonator into an arm of a superconducting interference device (SQUID). A part of the project will be devoted to developing methods of quantum manipulation with mechanical vibrations. Successful implementation of the project will require integration of mechanical and optical devices into nanoelectronic circuits. A close collaboration of theorists and experimentalists is essential for the success of the project. The theoretical research will concentrate on modeling cooling and read-out schemes by considering interaction of electrons with non-equilibrium phonons and photons. The project addresses basic research; mid-term and long-term applications are expected in the areas of sensing and quantum information.",Quantum Nanoelectromechanical Systems,FP7,31 August 2012,01 September 2009,2449218.0 QOCAN,University of Iceland * Háskóli Íslands,photonics,"A scientific trend, which has emerged in recent years, is to combine the methods of quantum optics with the advances in design and preparation of various nanostructures. This innovative field of physics, arising from the achievements of modern nanotechnology, offers the possibility of both the fundamental study of light-matter interaction in unusual artificial quantum systems and the development of optoelectronic nanodevices with unique characteristics. The proposed theoretical research lies within this interdisciplinary trend and joins two different important fields of the modern physics: the first one is devoted to the quantum optics, the second deals with the carbon-based nanostructures -carbon nanotubes and graphene. The main goal of the research is to combine the efforts of four scientific teams from Britain, Iceland, Russia and Brazil in achieving the following objectives: to develop fundamentals of the interaction between carbon nanostructures and quantum light, to reveal and analyse various quantum-electrodynamics effects in carbon nanostructures, and to create a theoretical basis for using carbon nanostructures as elements of novel optoelectronic nanodevices.",Quantum optics of carbon nanostructures,FP7,31 December 2016,01 January 2013,96000.0 QOFES,University of Vienna * Universität Wien,transport,"Quantum theory has been confirmed to extreme accuracy in a vast variety of experiments over the last century. While most of these experiments have been limited to a microscopic scale, several milestones in demonstrating quantum effects for more and more massive objects have been achieved, in particular by experiments on the interference of large molecules. In the last few years, a new approach to test quantum physics with significantly more massive objects has emerged where the electromagnetic field is used to achieve control over massive mechanical resonators, eventually into the quantum regime. In particular, quantum optomechanics deals with resonators that are coherently controlled via optical fields. Such systems allow for unprecedented levels of accuracy in the measurement of forces. Eventually, by preparing these massive resonators in non-classical states of motion, they may enable the investigation of quantum effects in a regime where gravitation becomes non-negligible. A limiting factor so far has been the coupling of the resonator to its environment. Using nanospheres levitated in optical trapping potentials, promises to overcome that limitation and will allow for high-precision measurements of gravitation as well as novel experiments on the frontier between quantum theory and the theory of relativity. Space provides an ideal environment for such experiments. Using a spacecraft like the one used in the LISA Pathfinder mission, it is possible to combine a micro-gravity environment, which allows for a much higher mass of the levitated spheres and reduces many sources of noise (e. g. seismic), with readily available optical space technology. This research proposal aims at designing possible experiments with levitated optomechanical resonators in space, testing the feasibility of these schemes in ground-based experiments, and investigating the prerequisites of fundamental optomechanical experiments in space.",Quantum Optomechanics for Fundamental Experiments in Space,FP7,02 April 2016,03 January 2011,75000.0 QOM,University of Vienna * Universität Wien,information and communications technology,"Quantum states of mechanical resonators promise access to completely new experimental regimes of physics: from unprecedented levels of force sensitivity to the generation of macroscopic quantum superpositions of massive objects containing up to 10^20 atoms. This opens up not only exciting possibilities for novel applications but also allows to (re)address fundamental questions of quantum physics, in particular its relation to the classical world. For this reason the preparation and control of mechanical quantum states has long been an enticing but far fetched goal of breakthrough character. With the advent of micro- and nano-mechanics this goal is at the verge of becoming an experimental reality. The last few years have witnessed unprecedented global progress in pushing mechanical systems towards the quantum regime. A thriving interdisciplinary field has emerged that aims to exploit the tremendous potential that lies in the control of mechanical quantum states. The main idea of this proposal is to combine the tools and concepts of quantum optics with micro- and nano-mechanical systems. Such combination provides a unique and powerful approach that allows, with a minimal set of experimental interactions, universal quantum control over mechanical systems via opto-mechanical interactions. The feasibility of the approach has recently been verified by us and by several other groups worldwide in a series of experimental demonstrations of mechanical laser cooling. The main objective of the proposed research is to go significantly beyond the current state-of-the-art and to develop the field of quantum-opto-mechanics to its full extent, both in experiment and theory. This will also increase the European visibility in this highly topical area of research. My professional background in both solid-state physics and quantum optics and quantum information will be of additional help in this highly interdisciplinary endeavour.",Quantum Optomechanics: quantum foundations and quantum information on the micro- and nanoscale,FP7,10 July 2016,11 January 2009,1670904.0 QON,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),information and communications technology,"Spins in nanostructures have emerged as a new paradigm for studying quantum optical phenomena in the solid-state. Motivated by potential applications in quantum information processing, the research in this field has focused on isolating a single confined spin from its environment and implementing coherent manipulation. On the other hand, it has been realized that the principal decoherence mechanisms for confined spins, stemming from interactions with nuclear or electron spin reservoirs, are intimately linked to fascinating many-body condensed-matter physics. We propose to use quantum optical techniques to investigate physics of nanostructures in two opposite but equally interesting regimes, where reservoir couplings are either suppressed to facilitate coherent control or enhanced to promote many body effects. The principal focus of our investigation of many-body phenomena will be on the first observation of optical signatures of the Kondo effect arising from exchange coupling between a confined spin and an electron spin reservoir. In addition, we propose to study nonequilibrium dynamics of quantum dot nuclear spins as well as strongly correlated system of interacting polaritons in coupled nano-cavities. To minimize spin decoherence and to implement quantum control, we propose to use nano-cavity assisted optical manipulation of two-electron spin states in double quantum dots; thanks to its resilience against spin decoherence, this system should allow us to realize elementary quantum information tasks such as spin-polarization conversion and spin entanglement. In addition to indium/gallium arsenide based structures, we propose to study semiconducting carbon nanotubes where hyperfine interactions that lead to spin decoherence can be avoided. Our nanotube experiments will focus on understanding the elementary quantum optical properties, with the ultimate goal of demonstrating coherent optical spin manipulation.",Quantum optics using nanostructures: from many-body physics to quantum information processing,FP7,10 July 2015,11 January 2008,2300000.0 QOQIP,Harvard University,information and communications technology,"We propose a theoretical investigation of the practical use of quantum optical systems for the implementation of quantum information processing. Employing a range of techniques and approaches, we will pursue the general scientific objective of identifying and characterizing optimized procedures for high-fidelity, robust and efficient quantum memories and gates involving atomic and condensed-matter systems. The main focus will be on coherent control of individual atoms in microscopic potentials. Existing gate proposals will be improved and new schemes will be proposed, relying on one hand on interaction mechanisms (e.g., molecular couplings) not yet fully exploited for enhancing entangling operations, and on the other hand on quantum optimal control methods to increase gate fidelities. Particular attention will be paid to the choice of qubit degrees of freedom and of manipulation procedures intrinsically less sensitive to decoherence sources and to imperfections in the control of the system, in order to relax experimental constraints for effective quantum computing. Innovative qubit manipulation and interfacing mechanisms in the context of mesoscopic condensed matter will be explored, in the sense of coupling to nanofabricated structures like quantum dots, superconducting devices and nanotubes. The training objectives concern on one hand deepening and broadening the applicant’s core competence in quantum optics and atomic physics applied to quantum information processing, and on the other hand complementing it with new knowledge in the field of condensed-matter mesoscopic systems and with new skills in the management of international scientific collaboration at the extra-European level, in view of consolidating prospects for independent research in the context of the return host institution, possibly even after the completion of the project.",Quantum Optics for Quantum Information Processing,FP6,31 May 2007,01 June 2005,247966.08 QPHOTON,University of Kassel * Universität Kassel,photonics,"Single photon emission, detection and manipulation will be explored on the basis of a novel semiconductor technology platform. By using semiconductor nanostructures like quantum dots, high-Q microcavity pillars or high-Q photonic crystal cavities, the interaction of individual photons with quantised electronic systems can be strongly enhanced to allow a full control of the light generation, detection and manipulation at the single photon level. Within the framework of the project major building blocks of future single photon systems will be developed and explored. Leading European research laboratories from universities, public research institutes and the industry with expertise in nanostructure technology, optoelectronic devices and quantum physics will work together. The project is expected to have a large impact on different areas of optical data communication (e.g. quantum cryptography) and on-chip data processing (like highly integrated single photon circuits). Several key devices, such as single photon emitters, single photon detectors as well as optical buffers, will be demonstrated.","High-Q Semiconductor Nanostructures for Single Photon Emission, Detection and Manipulation",FP6,30 April 2009,30 December 2005,1630000.0 QPOS,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),photonics,"Cavity optomechanics is a flourishing research field concerned with the study of macroscopic objects in a regime where quantum mechanical effects become apparent. A strong interaction between the optical field and the mechanical motion of optomechanical resonators, usually mediated by radiation pressure, enables both new photonic technologies as well as fundamental experiments that are at the heart of quantum mechanics. This proposal aims to study micro- and nano-optomechanical systems cooled close to their ground state of motion to advance both fundamental and applied concepts in quantum optomechanics. A first aim is to study a recently developed optomechanical device based on a 2D photonic crystal defect cavity. In particular, we aim to cool this device down to its ground state of motion by embedding it in a Helium-3 cryostat and using radiation pressure induced laser cooling to reach its ground state of motion. The high optomechanical coupling strength measured on these devices promises to allow ground state cooling with moderate efforts. A second objective is to implement the technique of motional side-band spectroscopy, adapted from ion trapping experiments, to characterize the degree of occupancy of the ground state of motion of optomechanical resonators, providing a definite quantum-mechanical signature in these macroscopic objects. Finally, we will use the recently observed effect of optomechanically-induced transparency (OMIT) in microresonators, in which the optomechanical coupling induces a very narrow transparency window accompanied by a strong group velocity reduction, for storing and stopping light pulses in optomechanical modes. This proposal will allow the applicant, a physicist recently graduated with distinction from the Institute of Photonic Sciences (ICFO) in Barcelona, to join the Laboratory of Photonics and Quantum Measurements in the Federal Institute of Technology in Lausanne (EPFL), a group with high recognition in this field of research.",Quantum Phenomena in Optomechanical Systems,FP7,30 April 2014,01 May 2012,184709.0 QSPINMOTION,IMEP-LAHC Laboratory,information and communications technology,"In quantum nanoelectronics, one of the paradigms is to use quantum mechanics in order to build more efficient nanoprocessors. In this context, the electron spin has been identified as a good degree of freedom to store and to manipulate quantum information efficiently. The defined building block of this quantum computer strategy is called a spin qubit. Towards this goal, intense experimental efforts have been invested in AlGaAs heterostructures where quantum dots with only one electron can be realized. In such a system, all the basic operations of a quantum nanoprocessor have been demonstrated in spin qubits and they constitute a very promising platform to study spin dynamics at the single electron level.",Quantum coherence and manipulation of a single flying electron spin,FP7,12 July 2019,01 January 2013,0.0 QTNMMM,University of Cambridge,information and communications technology,"Ability to exploit spin transport in semiconductor promises new logic devices with enhanced functionality, higher speeds and reduce power consumption. In addition, these new devices could be fabricated with many of the tools already used in the electronic industry. Therefore, one of the current objectives in the research in Spintronics is to develop new materials of easy compatibility with semiconductor materials and processing. Development of new materials suitable for spin-polarized transport supposes to devote many efforts and resources to the quest of 100 spinpolarized materials. The important room temperature ferromagnetic metals (Co, Fe and Ni) and their alloys have a spin-polarization of the carriers near the Fermi level of aprox. 50 %. Another research area, which provides serious challenge, is that of spin injection. Spin injection is the process by which a highly spin polarization current is transmitted from the ferromagnetic metal into another material such as another metal, a semiconductor, while retaining its spin-polarization character. The most difficult, and no doubt the most important, case of spin injection is that from a ferromagnetic into a semiconductor. However, despite considerable research efforts over the past decade, initial progress has been remarkably slow. Recent findings have been carried out by the Thin film Magnetism Group of Prof. Bland at Cavendish Laboratory concerning quantum transport in Cu nanowires. The nanowires were created by bringing macroscopic Cu wires into and out of contact, mechanically controlled break junction technique.",Quantum Transport in Nanoconstrictions made of no magnetic metals,FP6,29 February 2008,01 March 2006,168799.0 QUADOPS,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),photonics,"This project will fabricate and study devices known as spasers, which are the plasmonic analog of conventional lasers. In general, plasmonic devices exploit electromagnetic waves known as surface plasmon polaritons (herein shortened to surface plasmons) that propagate at the surface of a metal. Because these waves allow light to be concentrated in nanometer-scale volumes (hot spots), they can lead to enhanced light-matter interactions. Consequently, plasmonic structures have been studied for various photonic applications. However, because surface plasmons dissipate energy in the metal, intrinsic losses can severely limit light-matter interactions and the performance of plasmonic devices. Therefore, simple routes to counteract losses by adding a gain material to rejuvenate the surface plasmons have been sought. Moreover, by adding sufficient optical gain to a plasmonic resonator, a spaser can be created. This can lead to an extremely versatile nanoscale source of surface plasmons, photons, and/or intense electromagnetic fields. Therefore, spasers can enable fundamental studies on the limits of nanoscale optics as well as various applications. Recently, the very first spasers have appeared, leading to many open questions. To help address these, the PI will perform fundamental studies on a broad class of plasmonic devices that incorporate gain. The proposed research will take advantage of his expertise in two areas: (a) highly fluorescent semiconductor nanocrystals (colloidal quantum dots) for the gain material and (b) the fabrication of high-quality low-loss patterned metallic films. By combining these, an ideal route to spasers will be pursued. The project will develop designs and fabrication processes to create quantum-dot-decorated plasmonic resonators, and then investigate their gain, amplification, and spasing behavior. Another objective is to develop new approaches to place individual quantum dots at plasmonic hot spots and study their properties.",Quantum-Dot Plasmonics and Spasers,FP7,31 January 2019,01 February 2014,2500000.0 QUANPHOCHIP,Austrian Academy of Sciences * Österreichische Akademie der Wissenschaften,photonics,"Quantum technologies based on photons provide a promising path for building and using complex quantum photonic systems for both exploring fundamental physics and delivering quantum-enhanced technologies. While there have been impressive proof-of-principle demonstrations based upon on bulk optical elements, future technologies will require integrated optics architecture for improved performance, miniaturization and scalability. This project proposes to build a new class of quantum optics systems on a silicon chip. This integrated platform consists of integrated entangled-photon sources, high efficiency on-chip single-photon detectors and align-free quantum circuits to perform complex computing functions. This project will allow us to explore the forefront nanoscale quantum physics meanwhile simultaneously bring it to a practical engineering framework.",Quantum photonic chip,FP7,31 July 2015,01 August 2012,261853.0 QUANSIP,University of Sussex,photonics,"The proposed project has the goal to combine the benefits of two of the most successful approaches to the processing of quantum information, individually trapped ions and strong-coupling cavity QED. While ions in a radio-frequency trap are an ideal stationary system to manipulate quantum states, photons have been demonstrated to faithfully transmit quantum states over larger distances. Intertwining the two fields is a precondition for distributed quantum computation, a scheme in which a calculation is spread over several local sites. The principal challenge in the implementation of this scheme is the requirement for miniature-size traps and microscopic cavities, because only in this way suitable conditions for a strongly coupled interface between ions and photons are provided. The project will be realized by uniting researchers from the leading groups in the separate fields, which presently are spread over the European Union, to join their expertise to develop the required technologies and demonstrate their practical application. In the first phase of the project, novel methods for shrinking the mode volume of optical resonators will be investigated, including optical fibre cavities and small radius of curvature mirrors with ultra-low loss coatings. In parallel, part of the team will construct a trap with a novel architecture, based on micro- or nano-fabrication techniques. Once a suitable apparatus is constructed, a large range of applications in quantum information processing is feasible. The team will use the set-up as a very efficient single-photon source and, reversing the dynamics, as an equally efficient single-photon detector. The ability to transfer quantum states in a photonic channel can be employed to create entanglement between ions and photons, two local ions or between ions in distant locations. This achievement would clearly demonstrate quantum networking and be the first implementation of the quantum internet.",Quantum Networking With Single Ions and Photons,FP6,30 November 2010,01 March 2006,2094134.72 QUANT-DES-CNT,Weizmann Institute of Science,information and communications technology,"Quantum design, the ability to control the microscopic properties of a quantum system, has proven to be an invaluable tool in experimental physics. Carbon nanotubes are an ideal system to implement quantum design in the solid-state; their strongly interacting electrons, unusual spin properties, and unique mechanical qualities make them an excellent platform for studying quantum phenomena in low dimensions. However, for many years this potential has been hindered by the dominance of strong electronic disorder in this",Quantum Design in Carbon Nanotubes,FP7,12 July 2017,01 January 2011,0.0 QUANTIF,University of Warwick,information and communications technology,"Interfacial physicochemical processes are ubiquitous in chemistry, the life sciences and materials science, underpinning some of the most important scientific and technological challenges of the 21st century. The overarching aim of this proposal is to draw together separate strands of interfacial science by creating a unique holistic approach to the investigation of physicochemical processes and developing principles and methods which have cross-disciplinary application. To understand and optimise interfacial physicochemical processes, the major aspiration is to obtain high resolution pictures of chemical fluxes at a scale commensurate with our understanding of structure. The proposed research will address this need and break new ground by: (a) developing a family of innovative imaging methods capable of quantitatively visualising interfacial fluxes with unprecedented resolution that have wide application; and (b) establishing a common framework applicable to different fields of science through the usage of electrochemical principles. Experimental/instrumentation aspects will be supported by advanced modelling of mass transport-chemical reactivity. The research programme will focus on three distinct and important exemplar topics. (i) Electrochemical processes at new forms of carbon, including carbon nanotubes and graphene, where a major challenge is to identify the active sites for electron transfer. (ii) Membrane transport, where the goal is to identify the true factors controlling passive permeation across bilayer lipid membranes, with implications for understanding membrane function. (iii) Crystal growth/dissolution, where there is a major need to bridge kinetic and structural studies so as to understand the relationship between surface features and local flux. The project will allow a team of sufficient critical mass to be constituted to transfer knowledge between each area and establish a new way of addressing and understanding interfacial processes.",Quantitative Multidimensional Imaging of Interfacial Fluxes,FP7,08 July 2017,09 January 2010,2129141.0 QUANTUM COMPUTATION,Technical University of Dortmund * Technischen Universität Dortmund,information and communications technology,"Quantum information processing is an emerging research area where the quantum mechanical nature of physical systems is explored to improve the transmission and processing of information. In the case of quantum computation, specific algorithms use superpositions of quantum states that code information to achieve exponential speedup compared to conventional computers. The execution of such quantum algorithms in an actual implementation uses unitary transformations referred to as quantum gates to drive the system through the individual steps of the quantum algorithm. In the proposed project, we plan to design and implement such gates on the basis of geometric quantum phases. For this purpose, time-dependent control fields are applied to the system in such a way that it undergoes a closed circuit that brings it back to the initial state, up to a phase factor that depends on the geometry of the circuit. If the circuit is designed properly, this phase factor implements a quantum gate operation. It has been shown that the phase factors resulting from such circuits are immune to certain local fluctuations that may negatively affect the precision of conventional gate operations. Within this project, we plan to use this approach to design gates for one- and two-qubit operations and optimize them with respect to three main criteria: speed, robustness, and performance in the presence of noise. Experimental assessments of the performance of these gates will be carried out by NMR in liquids, which represents the most advanced implementation of a quantum information processor available today; results should be applicable to other implementations. The main benefit of this project will be an improved performance of quantum computers and a step towards reliable quantum information processing. The project should also establish a basis for a future cooperations between European and Chinese research groups working in this rapidly evolving field.",Robust Quantum Computation with Geometric Phases,FP6,30 September 2007,01 October 2005,158197.7 QUANTUM MODELLING,Consejo Superior De Investigaciones Científicas (CSIC),energy,"The aim of this project is to use insights from exactly solvable models in order to improve the accuracy of quantum Monte Carlo methods for the modelling of correlated quantum systems such as ultracold atomic gases, nuclear matter and non-conventional superconductors. This will lead to a more precise understanding of the quantum correlations that exist in such systems and will allow to extend these insights to nuclear matter, neutron-rich atomic nuclei or neutron stars. The project also aims to clarify the relation between these systems and recent experiments on ultracold atomic gases. Through the development of new numerical simulation techniques the project will have considerable impact on the fields of nanotechnology (high-Tc superconductors, carbon nanotubes), quantum computing, nuclear waste transmutation and nuclear energy production.",New computational tools for the modelling of correlations in quantum systems.,FP7,30 November 2010,01 December 2008,207317.0 QUANTUM PLASMONICS,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"I propose to unravel the quantum properties of Surface Plasmon Polaritons (SPPs), thanks to an experimental approach new in France and used by only a couple of groups in Europe. This ambitious project I propose will be conducted at the Institut Néel, in Grenoble (France), as the first project I would develop there as a newly appointed permanent CNRS researcher. SPPs, thanks to their ability to highly confine the electromagnetic field are expected to have applications in quantum optics, computing, and to foster photon-photon interactions at nanometric scales. However, whether they will truly lead to viable applications is controversial at present, because the benefits of SPPs come at the cost of high losses. Very little is known about SPPs in the quantum regime, and my project proposes to fully investigate their potential. The study will use a single photon source using nonlinear processes in a crystal, which produces phonton pairs entangled on the polarisation. The single photons are coupled into single SPPs thanks to a microscopy setup, and to appropriate design of the plasmonic devices. After undergoing the operation performed by the device, the single SPPs are then coupled back into photons and the measurements are performed on these photons. Devices will be produced to generate entanglement on ultrasmall scales and the quality of the entanglement quantified. Experiments will also be conducted under high confinement of the electromagnetic field, which is one of the conditions to reach the most challenging targets of the work: developing SPP-based quantum metrology and produce nanometric single photon switches. Success could lead to the development of novel optical quantum information processing devices of nanometric dimensions.",Quantum Plasmonics,FP7,28 February 2018,01 March 2014,100000.0 QUANTUM QUENCH,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,information and communications technology,"Compared to our understanding of equilibrium physics, the study of out of equilibrium dynamical phenomena is still in its infancy. Equilibrium systems can often be understood using mean field theory, universality and renormalisation group techniques. The situation is different away from equilibrium: there are fewer theoretical tools available, new approaches have to be developed and new organising principles have to be found.",Universality in the Non-Equilibrium Dynamics of Strongly Correlated Quantum Systems,FP7,09 June 2017,10 January 2013,0.0 QUANTUM SPACE-TIME,"Imperial College of Science, Technology and Medicine",information and communications technology,"One of the main problems of modern theoretical physics is to construct a consistent theory of Quantum Gravity (QG). Great achievements were done in this direction using non-perturbative quantization techniques (Spinfoam-Loop Quantum Gravity). If the mathematical framework is getting well understood, it is not completely clear how one should make contact with the forthcoming experiments (GLAST, AUGER) trying to measure some QG effects. The key points to make a contact between experiment and theory are for example the notion of Deformed Special Relativity, or the notion of Quantum Reference Frame. A reference frame is necessary in General Relativity to make predictions (see e.g. the Global Positioning System). One needs then to define their alter-ego in the quantum context. This prompts the idea of Quantum Geometry or Non-Commutative Geometry. This is a notion I intend to explore. With the current proposed experiments one doesn¿t expect to probe the full regime of QG, it is therefore crucial to understand how the quantum effects are renormalized to a scale far from the Planck length. In fact the renormalization idea is also a key idea in Deformed Special Relativity (DSR). In some sense this theory is the one that experiments are going to probe as it can be considered as a low energy limit of QG. It is also an example of a Non commutative geometry. We intend to study these different aspects of renormalization or classical limit, in the realm of pure quantum Gravity or more in an effective way in the DSR setting. It is interesting that some of the problems, or mathematical techniques met in the QG setting are also found in Quantum Information Theory (QIT), and Quantum Computing. For example the notion of Quantum Reference Frame is already existing in QI. We intend to create some more concrete interactions between the two fields, so that one can expect to have some new concepts and techniques to emerge, for the benefit of all.",Quantum Space-Time,FP6,31 August 2007,01 September 2005,0.0 QUANTUMCANDI,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,information and communications technology,"Coherent control and sensitive detection of quantum states in condensed matter are among the most topical challenges of modern physics. They drive the development of novel materials, theoretical concepts, and experimental methods to advance our understanding of fundamental laws of quantum mechanics and to create transformative technologies for future applications. During the past decades carbon has emerged as a new material platform to address these challenges: graphene and carbon nanotubes have been created as paradigm systems with exceptional physical properties.",Interfacing quantum states in carbon nanotube devices,FP7,12 July 2020,01 January 2014,0.0 QUANTUMDOTIMPRINT,University of Potsdam * Universität Potsdam,health,"Molecular imprinting of polymers (MIP) is a method to obtain highly functionalised polymers containing binding sites that are able to selectively recognize analyte molecules. In general, this method is based on co-polymerisation of functional monomers around the analyte. Consequently, a cavity formed in the polymer is complementary to the analyte not only in size and shape, but also by the electron density distribution. Thus the MIP is capable of selectively detecting the analyte in surrounding environment. Surface functionalised quantum dots can be applied in a variety of biological investigations, in which traditionally used fluorescent organic molecules fail due to lack of long-term stability and simultaneous detection of multiple signals. The ability to make QDs water soluble and target them towards specific biomolecules either by surface functionalisation or polymeric shell implementation leads to their promising applications in cellular labelling, deep-tissue imaging, immunoassay as well as efficient fluorescence resonance energy transfer donors or acceptors. The main objective of the project is the preparation of quantum dots having biocompatible MIP shell capable of selectively recognizing antibiotics. By combining high selectivity of the MIP and sensitivity of QDs with application of this hybrid material to medical research the project exhibits high inter- and multidisciplinary level as significantly relevant for nowadays sciences. The nanosensors will be characterized in terms of their long-term stability, sensitivity, selectivity, response time, and will subsequently be evaluated for analyte monitoring in biotechnology and medical research. The investigations on the new sensor materials will allow for the study of recognition reactions at the nanometer scale and foster the development of highly defined self-organizing nanostructures.",Quantum dots having molecularly imprinted nanoshell for recognition of antibiotics,FP7,30 September 2012,01 October 2009,45000.0 QUANTUMOPTOELECTR,Technische Universiteit Delft * Delft University of Technology,photonics,"We propose to develop an opto-electronics interface between single-electron devices and single-photon optics. The ultimate limit in the miniaturization of electronics and photonics is at the nanometer scale. Here the signal level can be controlled at the fundamental level of a single electron for electricity and a single photon for light. These limits are actively being pursued for scientific interest with possible applications in the new area of quantum information science. Yet, these efforts occur separately in the distinct communities of solid state electronics and quantum optics. Here we propose to develop a toolbox for interfacing electronics and optics on the level of single electrons and photons. The basic building block is a nanoscale pn-junction defined in a semiconductor nanowire, which is the most versatile material system for single electron to single photon conversion. We will develop the following technology: (1) growth of complex semiconductor nanowires (2) quantum state transfer for copying the information stored in an electron quantum state onto a photon state (3) single-photon optical-chip with on-chip guiding via single plasmons and on-chip detection with a superconducting detector. Besides being fundamentally interesting by itself, this new toolbox opens a new area of experiments where qubits processed in solid state nano-devices are coupled quantum mechanically over long distances via photons as signal carriers to various kinds of other interesting quantum system (e.g. solid state quantum dots, confined nuclear spins and atomic vapours).",Quantum Opto-Electronics,FP7,31 October 2013,01 January 2009,1800000.0 QUARMA,Joseph Fourier University * Université Joseph Fourier,information and communications technology,"Our project aims at observing the spatial modulations of local electron probability density along a quantum ring fabricated from a two-dimensional electron gas (2DEG) formed in an InGaAs heterostructure. As a magnetic field is applied perpendicular to the plane of such a ring, a periodic pattern of maxima and minima of electron probability density is predicted to appear, due to interferences of electron partial waves inside the ring (these interferences give rise to the well-known Aharonov-Bohm effect, causing periodic oscillations in the ring magnetoresistance). In order to observe this phenomenon, we plan to use a low temperature (4.2 K) atomic force microscope (AFM) in non-contact mode. A voltage bias will be applied on the tip of the AFM in order to create a local perturbation in the 2DEG underneath. The principle is to record the changes of conductance of the quantum ring as a function of the tip position (i.e. the perturbation position) over the quantum ring, which will produce images related to the changes of electron probability density (the technique was demonstrated for quantum point contacts in M.A. Topinka et al., Science 289, 2323 (2000)). Using voltages applied on lateral (in-plane) gates patterned close to the quantum ring, we will investigate the influence of the coupling of the ring to external electron reservoirs as well as the influence of the asymmetry of the ring. The biased scanning tip will also be used as a static scatterer on one arm of the ring, and the influence of the position of the tip on Aharonov-Bohm oscillations will be characterized. Potential outcomes of this project are in the field of experimental quantum physics, quantum computation and electron optics.",Quantum Ring Mapping,FP6,31 August 2006,01 May 2005,100914.0 QUATRAFO,Slovak University of Technology * Slovenská technická univerzita v Bratislave,information and communications technology,"The ERG will enable me to establish a research unit at the Slovak University of Technology that will capitalise on my previous postdoctoral research experience from the NANOPHASE Marie Curie RTN. This transfer of expertise, together with the active research along the scientific objectives of this proposal, and my international collaborative activities, will guarantee me long term employment at the host institution and successful career development within European science. The scientific objective of my proposal is to achieve deeper understanding of the fundamental physical processes underlining the presently rapidly growing field of molecular electronics and nanotechnology. Specifically, my attention is focused on the flow of electric current. As a result of the proposed work I will be able to(l Quantitatively describe the electronic structure of a real molecular device with accurate account for electron-electron interactions, (2) formulate and perform calculation of the conductance for interacting model electronic systems and (3) describe devices carrying current, far from equilibrium, using a novel technique based on maximum entropy principle. A substantial part of the proposed research is a joint collaboration with several nodes of the NANOPHASE RTN. At the same time it covers new collaborations with national research groups as well. As such, it is a research proposal, fully integrated into the growing European Research Area and directly contributing to its further development.",Quantum Transport in Focus,FP6,14 September 2005,15 September 2004,40000.0 QUELE,University of Camerino * Università degli Studi di Camerino,information and communications technology,"Following our successful assessment project QUELE, we aim with the present proposal at building and operating a universal scalable quantum processor consisting of 3-10 trapped electrons. Confinement will be performed in a Penning trap using a new concept of planar geometry. Ultra-high vacuum conditions will minimize the effect of the environment. The use of static fields is an advantage over rf ion traps because of weaker decoherence effects due to the absence of r.f. heating. The accomplishment of the final task requires a number of theoretical and experimental intermediate steps:- Design, set-up, and operation of a highly innovative multi-electron planar trap;- Cooling of the electron motion via mode coupling between the cyclotron and axial oscillator;- Single particle addressability by adjusting the voltage applied to the trap electrodes and introducing a small magnetic field gradient;- Initialization to a fiducial state of the qubits, encoded in the electron spin and in the quantized external degrees of freedom (axial and cyclotron oscillators);- To develop the microwave and radio-frequency sources required in one- and two-qubit operations on a single electron;- Realization of two-qubit operations on different electrons via the controlled Coulomb interaction, switching on and off resonance any two axial oscillators, by image charge coupling;- To understand the decoherence processes and estimate the relevant decoherence rates, taking into account intrinsic (thermal) and technical noise sources;- To characterize the performances of our prototype of quantum computer in terms of achievable fidelity and clock speed;- To devise and implement a strategy for measuring the final state of individual qubits.With our original prototype of quantum processor we expect to experimentally validate some quantum algorithms, to implement error correction schemes, and to assess the fault-tolerance of the device.",Quantum computing with trapped electrons,FP6,31 August 2008,31 August 2004,1400000.0 QUEST,Technion Israel Institute of Technology,photonics,"The goal of the proposed project is to employ novel states of matter for the development of new devices for quantum technologies, optoelectronics and ultrafast nanoelectronics. Speeding up and miniaturization of the existing electronics are approaching their physical limits. Novel states of mater are a rapidly growing field of science including quantum condensates and superconductors. One of the topics in the proposed project explores devices based on condensates of exciton-polaritons in semiconductors, representing both: ultrafast low-dissipation electronics due to their light-matter superfluid properties, as well as extremely nonlinear optics useful for quantum photonics. Another approach in the proposed project, which can provide a new direction in optoelectronic devices, is based on combining superconductors with semiconductors. The project takes advantage of the recent progress in high-temperature superconductors, which makes these technologies significantly more practical. Lately, a novel paradigm for finding new properties in the solid state has emerged - through the sudden change in topological invariants rather than breaking of symmetries. These topological phases of matter have been demonstrated to exist at the surface of some materials with strong spin-orbit coupling, revealing novel physical properties, including dissipationless spin currents with potential applications in spintronics and quantum technologies. A part of the proposed research focuses on devices based on proximity-induced high-temperature superconductivity in such topological insulators. This proximity effect has been predicted recently to produce the elusive Majorana fermion, which is of great interest for condensed-matter physics and quantum computation.",QUantum-device Engineering with novel STates of matter,FP7,31 March 2018,01 April 2014,100000.0 QUEST,University of Basel * Universität Basel,information and communications technology,"The quantum world is by far larger than the classical one. It is entanglement, closely linked to non-locality, that spans this larger space manifold. Entanglement plays a central role in emerging quantum technology aiming to harvest quantum space. From the experimentalist’s point of view working in nanoelectronics, there is no instrument on the shelf yet, that would measure the degree of entanglement. This we would like to change with QUEST.",Quantum Entanglement in Electronic Solid State Devices,FP7,03 July 2019,04 January 2012,0.0 QUEVADIS,University of Vienna * Universität Wien,information and communications technology,"Due to the ongoing miniaturization of devices, one of the central challenges of the 21st century's technology will be to handle quantum effects at the nanoscale. A first fundamental paradigm shift happened in the mid '90s when it was realized that quantum effects, which from the traditional point of view put fundamental limits on the possible miniaturization, could be exploited to do information theoretic tasks impossible with classical devices. The main obstacle in building such quantum devices however is the occurrence of decoherence, by which coherence within the quantum device gets degraded due to the coupling with the environment.",Quantum Engineering via Dissipation,FP7,09 June 2014,06 January 2009,0.0 QUIDPROQUO,IRCCS - Centro di Riferimento Oncologico di Aviano (CRO),health,"The main goal of this proposal is to introduce innovative devices and protocols (based on nano- topography, the response of micro-(nano-)mechanical oscillators and nano-fluidics) to carry out, precise, high throughput, high sensitivity, and low cost interactomic measurements. We aim at measuring, in parallel, the concentration of up to hundreds of proteins, in samples down to the single cell level, following the real time concentrations of several biomarkers in patient's serum down to femto-molar concentrations. We plan to develop our program a) by applying the principles and practice of intrinsically differential measurements, e.g. by building a nano-fluidic equivalent of the Wheatstone Bridge, a standard tool for differential high sensitivity electrical resistance measurements and b) by using the vertical equivalent of cantilever oscillators (pillars) that we plan to use as quartz 'microbalances' that are 10,000 time more sensitive than cantilevers w. r. t. measurable min. mass and 100 time more sensitive w. r. t. dilution. The proposal's core strategy is to exploit the PI's expertise in innovative instrumentation and his integrated physical chemistry know-how, leading a highly multi-disciplinary staff to closely interact with first class medical staff in hospital settings to solve, and validate the solution of, relevant medical problems. For instance, the sensitivity of our sensors will allow protein analysis from very small and homogeneous samples of tumor cells and the monitoring of very dilute concentrations of autoimmune response to antibody treatment allowing, in addition to improved cancer diagnostics, also the prediction of patient response to treatment. The convergence between chemistry and biology, through nanotechnology, with medical diagnostics would enable our team to come up with more versatile and reliable diagnostic tools while stimulating fundamental research in fields as diverse as stem cells differentiation and the study of cell physiopathology.","Molecular Nanotechnology for Life Science Applications: QUantitative Interactomics for Diagnostics, PROteomics and QUantitative Oncology",FP7,30 June 2016,01 July 2011,2979700.0 QUMOCA,Medical University of Graz * Medizinische Universität Graz,health,"The proposed work focuses on vascular smooth muscle cells, which control our veins and arteries. Their ability to contract is governed by the amount of calcium ions inside the cell. Sodium too in these cells helps regulate cellular calcium levels. In the past two decades, researchers have observed that during muscle contraction intracellular calcium concentration varies periodically. These variations are referred to as oscillations. Our research has helped establish a link between these oscillations and the health of the cell, and consequently of our cardiovascular system. In the past we have shown that such calcium ion movements in the thin smooth muscle cells spiraling around our blood vessels are controlled by complex ultra-structure of membranes within the smooth muscle cells. Since these molecular processes take place at a scale that cannot be visualized and measured by available instrumentation, we will develop quantitative computational models of calcium and sodium movement in these cells. This will greatly enhance our understanding of the basic cellular mechanisms behind these oscillations and of the machinery that enables these mechanisms. The project will use methods and concepts from pharmacology, microscopy and biophysics. The medical relevance of this research is related to the fact that all of our daily functions including movements of our limbs, beating of our hearts, regulation of our blood circulation, as well as short term memory are regulated by movements of intracellular calcium ions. Joining the researcher's expertise in quantitative modeling of ion transport in vascular smooth muscle and the partner's knowledge and understanding of ion transporters provides an ideal situation both to improve our understanding of the above mentioned mechanisms as well as their link to cardiovascular disease.",Quantitative Modeling of Calcium Signaling in Vascular Smooth Muscle Nanojunctions,FP7,09 February 2016,10 February 2014,248379.0 QUOMATERS,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),photonics,"Interfacing quantum optics with nanotechnology could boost the prospects for the integration of scalable quantum information technologies. Quantum information processing is a key future technology that promises superior communication and computing performance beyond classical information. Any candidate to realize its full potential will require solid-state coherent units with long-range interactions. The most promising approaches rely on photons and spins. Recent demonstrations of the quantized character of surface plasmons -oscillations of electrons bound to photons -have spurred research in miniaturized quantum optics with plasmons, known as quantum plasmonics. Despite the interest, experiments aiming at nanoscale quantum circuits and communication with plasmons are still in their infancy because of the difficult generation of a coherent interaction between different single-plasmon nanosources. Here we propose a conceptually new route to quantum plasmonics that harnesses the properties of quantum materials. These are tunable quantum systems with properties that emerge from the strong interaction between coherent units, with macroscopic states that are determined by collective quantum many-body physics. We will create a unique quantum state: a Bose-Einstein condensate of surface plasmons for which quantum properties become apparent in a many-emitter system. This will allow the construction of a quantum metamaterial, a reconfigurable optical material that exploits coherence. Topological insulators -another fascinating quantum material that is metallic on its surface, insulating in its bulk and locks electronic spin to current direction -will be shown to support plasmons and spin-plasmons (a plasmon travelling with a spin wave). This will bridge spintronics and nanophotonics, the two most promising approaches for integrated quantum information. Both plasmonic quantum materials will be novel resources for classical and quantum nanophotonic devices.",Plasmonics of Quantum Materials: from surface plasmon condensation to quantum metamaterials,FP7,28 February 2017,01 March 2014,265736.0 QUORUM,University of Naples Federico II * Università degli Studi di Napoli Federico II,environment,"Fungi have proved to be a source of bioactive natural products and industrially important target products such as (i). Enzymes, (ii). Bioplastics, (iii). Bio-dyes, (iv). Vitamins, (v)? The overall aim of this proposal is to use nanotechnology using natural molecules involved in fungal cell communications and mini-scale process parameters, to maintain and improve productivity for the white biotech industry of the commercially important bioproduct, and particularly laccases. The specific objectives of this proposal are: Using a Quorum Sensing approach at nano-scale for better understanding of biosynthesis of the industrially important target products; Quorum sensing and signal transduction in relation to fungal physiology and morphology in agitated systems; Comparative analyses of fungal cell communication in small and large scale submerged fermentations; The relevance and interrelation of traditional scale-up factors to quorum sensing in fungal cultures. The QUORUM project is based on a multidisciplinary approach, and builds a dynamic relation between 8 partners (1 SME and 7 Universities and Research Centres) from 7 countries. The QUORUM project will enhance competitiveness and sustainability of European industries by the development of leading-edge advances in environmentally respectful, energy efficiency, resource efficient processes and product technology. Two main technology innovation areas are concerned: enzymes and fine chemical productions. The QUORUM project will lead to a positive impact on economy through new/increased added value products, a beneficial impact on environmental issues, and new production models ?based on knowledge? to replace ?trial error? will be proposed to the industrial biotechnology sector in the value chain. The QUORUM project will support the ?Action Plan for environmental technology? (COM 131-2003) as well as the ?Life sciences and biotechnology: a strategy for Europe? (COM 27-2002).","Discovering Quorum Sensing in industrially useful Fungi, a novel approach at molecular level for scaling-up in white biotech.",FP6,31 October 2009,01 November 2006,1999920.0 QUOWSS,University of Bristol,photonics,"In this project I will investigate the interaction between quantum light and matter in optical structures that are at or below the wavelength scale. Such devices could provide unprecedented performance in the storage of data, the switching of light and the generation of light of tailored properties. I will address this topic through the study of 2-level systems (quantum dots, N-V centres, atoms), and non-linear materials (Ç(2) ,Ç(3) ) in various nanoscale dielectric and conducting structures. This will include: " quasi 1D systems such as pillar microcavities, " 2D systems such as microstructured fibres and suspended waveguide photonic bandgap cavities " 3D systems such as single particle assembled 3D nano-cavities I will design suitable systems using the wide suite of electromagnetic modelling softwares available in my group. This will also involve the inclusion of the allowed modes and their interaction with single two-level quantum systems and non-linear materials.",Quantum Optics in Wavelength Scale Structures,FP7,31 January 2015,01 February 2010,2500000.0 QUPOM,Institute of Physics * Institut za fiziku,health,"Our research is in quantum optics and holography. Our development, responsible for most of the R & D of optical standards in the country is based on stabilized lasers and interferometry. We provide services through accredited measurements. Senior stuff teach graduate courses at Physics Faculty and are mentors of MsC and PhD thesis. The Center has thirteen members, five senior researchers, seven graduate students and one technician. Part time members are professor from the Medical faculty and the student. All of them work together on the same project financed by the Ministry of science. We research quantum interference phenomena during laser-atom interaction that generates sub natural linewidth, enhancement of the index of refraction, non-linear magneto-optical effects with applications in a new generation of atomic clocks, standards of length, ultra precision magnetometry, communication systems for pulse compression and for optical memories. We study photon interference as a process of accumulation in time of individual events (impacts), recorded in recent experiments in grating interferometers as well as in Mach Zehnder interferometer. We develop new holographic materials, use novel applications of holographic methods and materials in biomedicine and nano-scale patterning, use optical coherence tomography for accurate measurement of internal dental structures, develop holographic nanostructures and their use in optical metrology. We have obtained support from nine leaders in our field. Their names and letters are at http://www.laser.phy.bg.ac.yu/fp6-inco.php. They will help both our students and stuff to increase knowledge and experience in modern optics. We will obtain equipment necessary for the competitive research and hire new students. The work will improve the standards of optical metrology and measuring methods, incorporate into ISO system of accredited measurements and improve quality of our services for the society.",Reinforcing research center for quantum and optical metrology,FP6,31 December 2009,01 July 2006,250000.0 QUROPE,University of Copenhagen * Københavns Universitet,information and communications technology,"Quantum Information Processing and Communication (QIPC) is a vigorously active cross-disciplinary field drawing upon theoretical and experimental physics, computer science, engineering, mathematics, and material science. Despite its young age (the first groundbreaking proposals were published in the early- and mid 90s) this novel field is by now one of the most active in natural sciences, as witnessed by a large number of publications in such prominent journals as Nature and Science. The importance of various research activities within QIPC has been recognized by the FET Open programme, and QIPC is overall one of the most active research fields within FET. At present the European QIPC community has reached a critical mass in all relevant subfields, but there is a clear lack of a structure unifying and coordinating all this variety of research, educational and commercial efforts at the European level. The proposed CA will establish a formal and structured approach for further development of strategic vision, collaboration, and dissemination. The emergence of a new QIPC technology will make an enormous contribution to the future of Europe ¿ witness the effect generated by the vast growth in conventional information technology over recent decades. Rather than replacing IT, a new QIT will emerge alongside it, creating new jobs. The new technology will enable us to perform previously impossible (or utterly difficult) tasks in computing and absolutely secure communication, and therefore contribute to improving the quality of life. The exploitation of quantum effects may revolutionize information processing in the 21st century. QUROPE will ensure a further systematic advancement of the state of the art in QIPC by converging all efforts at the European level towards building up the QIPC community, in order to develop a common strategy and vision in an orderly and democratic way and prepare the necessary input for the research programmes of the European commission.",QUANTUM INFORMATION PROCESSING AND COMMUNICATION IN EUROPE,FP6,30 November 2009,30 August 2006,1000000.0 QUSIM,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),information and communications technology,"This project's main goal is the theoretical design of a quantum simulator of magnetism that makes use of current technology for the manipulation of trapped ions. The implementation of this idea would lead to the simulation of complex spin models that are not well understood, and also to the first observation of quantum phase transitions in a system of trapped ions. The project will pursue the following objectives: (1) Elaboration of methods and protocols that experimentalists working with trapped ions can follow in order to simulate quantum magnetism, and description of the optimum conditions to minimize errors during the quantum simulation. (2) Description of the many-body state of the effective spin models to be simulated in ion traps, and, in particular, of the quantum phase transitions. Calculation of critical exponents, and properties of spin systems that can be translated into experimental observables of trapped ions (effective magnetization, and correlation functions, for example). (3) Design of proposals for the manipulation of the quantum state of the effective spins for entanglement creation and transmission of quantum information. Our project would lead to one of the first applications of the techniques developed in the field of the implementations of Quantum Information, and would fill the gap that separates current experiments from the long-term goal of quantum computation.",Simulation of Quantum Magnetism with Trapped Ions,FP6,30 September 2006,01 October 2004,142918.0 QUTECH,Ben-Gurion University of the Negev,information and communications technology,"Matter wave quantum technology (MWQT) is an emerging field in which fundamental systems are kept isolated from their environment long enough for them to be useful as quantum systems. Such systems, involving ultracold atoms or ions, have for example already set the best time standards. They are now being developed via interferometric schemes into acceleration sensors for ultra accurate navigation systems, and as highly sensitive gravitational field sensors. More futuristic applications involve secure communication (quantum cryptography) and the quantum computer. Although much progress has been made, many problems remain to be solved. In order to bring these systems closer to the level of applicable technologies, much effort has been dedicated in recent years to miniaturization and integration. A specific example of a successful effort has been the and quot; atomchip and quot; wherein techniques from the semiconductor industry are used to create magnetic fields in which atoms are trapped or guided above a chip. This combination of the fields of quantum optics and microelectronics has brought about great achievements in the past 5 years. Similar efforts have been made with the and quot; ionchip and quot; where a quantum logic gate has been achieved. This expertise serves as the base for the project, while this proposal emphasizes adding new know-how by a unique synergism of experts from the fields of molecular electronics and photonics. In this project, we suggest combining two additional, completely new fields--molecular electronics and tunable photonics--with the above atomchip and ionchip devices, thus enabling a leap in their capabilities. In both fields, much adaptation is needed of the presently available technology, but the effort is worthwhile as a final successful outcome will provide a major step forward for MWQT. The MC fellow has extensive related background. He will receive expert training in all the above four disciplines of science and technology.",Molecular Electronics and Tunable Photonics for Quantum Technology,FP6,03 June 2009,04 June 2007,172253.0 R&D ACCESS,Design And Reuse,information and communications technology,"The objective of the R&D ACCESS proposal is to identify R&D results on semiconductor design from FP7 projects and to provide these results to partners from outside the consortia. The R&D results are divided into four categories: 1) Training and Education, 2) Intellectual Properties, 3) Design Tools and 4) Design Methodologies.",Access to research results on semiconductor design,FP7,10 July 2014,11 January 2009,0.0 R2R-CIGS,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,energy,"CIGS solar module technology on rigid glass substrate is already mature and industrial companies are producing hundreds of MWp each year. Bringing flexible CIGS solar modules to industrial maturity will yield the next breakthrough for further cost reduction by taking into account the inherent advantages of thin film technology, e.g. high throughput and large scale coating with less energy and material consumption. The aim of R2R-CIGS is to develop efficient flexible solar modules by implementing innovative cost-effective processes such that production costs below 0.5 €/Wp can be achieved in large volume factories with annual capacity of 500MWp in future. The main objectives of this project are: • Flexible solar cells on polymer film with 20% efficiency and mini-module with 16% efficiency by control of composition gradient, surface, and interface properties on nano-scale • Transfer of innovative buffer layer process for roll-to-roll manufacturing and replacing problematic CBD-CdS by higher yield processes such as (spatial) ALD and ultrasonic spray • Developing fully laser based patterning technology for monolithic interconnection in R2R pilot-line • Scale-up of static multi-stage CIGS deposition process from laboratory scale towards inline R2R compatible processes • Implementation of the up-scaled multi-stage CIGS deposition process into pilot lines for R2R manufacturing of flexible CIGS modules • Development of moisture barrier with WVTR < 5x10-4 g/m2/d and cost-effective encapsulation • Decrease cost of ownership for enabling production costs below 0.5 €/Wp for a commercial plant with annual production of 500 MWp in future",Roll-to-roll manufacturing of high efficiency and low cost flexible CIGS solar modules,FP7,30 September 2015,01 April 2012,7021501.0 RABBITCELLPSU,École Normale Supérieure,health,"This project brings together a research fellow with a unique background in medical physics, electronics and chemistry to the biophysics group at ENS. The aim is to develop a new type of battery based on living cardiac myocyte cells. Through the application of newly-learnt life science skills the fellow will demonstrate how microfluidics can be used for the realization of this perpetual bio-battery. Global demographics is skewing to that of an aging population which has a higher prevalence of age related diseases and growing dependence on 'medical fixes.' Pacemakers and other medical electronics require batteries which must be surgically replaced every 5-7 yrs. The hazardous waste and pain associated with surgical replacement of implanted batteries could be removed by the creation of a cellular power supply which uses blood glucose and oxygen as fuel and oxidizer to produce usable electricity. Demand for such a power supply in the future will be huge and presents an opportunity for Europe to get ahead of America. The scientific objectives are: • To create microfluidic devices with high resolution nano-structures for confining cells to specific channel regions. • To culture rabbit cardiac myocytes both individually and in colonies of varying sizes on the microfluidic device within the special adhesion zones. • To use electrophysiological and microscopic techniques to better understand the propagation of action potential through individual and colonies of cardiac cells which are specially separated within a microfluidic channel geometry. The planned deliverables are: • A series of microfluidic devices capable of supporting individual and colonies of myocytes; • A demonstrable cellular power supply capable of producing pulsed or continuous electrical currents; • Several high quality publications relating to myocyte communication and propagation of action potentials for use in an implantable cellular power supply.",THE DEVELOPMENT OF AN IMPLANTABLE CELLULAR POWER SUPPLY BASED ON RABBIT CARDIAC CELLS.,FP7,30 November 2013,01 December 2011,185248.0 RAD-NANO-BIOMOL,The Open University,health,"This project is centered upon the experimental study of ionization induced processes in mixed clusters as model systems for complex environments. The first objective is to compare the irradiation of a molecule within a cluster with the case of the molecule in isolation, extending to the investigation of different types of radiation upon clusters of different sizes, compositions, and charge. In addition to their relevance to fundamental aspects of molecular and statistical physics, these experiments will help to bridge the 'complexity gap' between the current understanding of radiation effects in the gas phase and in a biological medium. This represents a major current research challenge for physicists, chemists, and biologists, with important applications in quantifying the effects of radiation exposure, in particular during cancer therapies. A mobile cluster source will be constructed at the Open University (UK) in order to carry out 2-photon ionization experiments which probe the effects of solvated water molecules upon the excited states of DNA and RNA base molecules and the associated dissociation pathways. The apparatus will be transported to Queen's University Belfast to perform the first ion impact experiments upon these model systems, enabling analogies to be drawn with processes initiated in hadron-therapy treatments. Further novel experiments will be carried out at the Nuclear Physics Institute of Lyon probing collisions between protons and mass-selected nucleobase-water cluster ions. The integrated research program will advance the understanding of the roles of specific molecules and inter-molecular processes in radiation induced damage to DNA and can thereby improve the reliability of bio-medical simulations. An MC reintegration grant is sought for the acquisition of a state-of-the-art mass spectrometer and to finance a PhD studentship in partnership with the Open University: key elements to enhance the development and impact of this research.",Irradiation of model biomolecular nano-systems,FP7,31 January 2011,01 February 2008,45000.0 RADAR,Centre Suisse d'Electronique et de Microtechnique (CSEM) - Recherche et Developpement,health,"RADAR is a 7-member consortium that aims to develop a robust, sensitive, and versatile label-free, biosensor platform for spot measurements and on-line monitoring of toxins and pollutants in food production processes and in the aquatic environment. Specificity towards chemical pollutants and toxins is achieved by using recombinant receptors (namely the estrogen receptor and the aryl hydrocarbon receptor) whose amino acid sequences have been rationally designed based on genomic and functional information from aquatic organisms. Sensitivity of the biosensor is increased by the unique combination of isotachophoretic pre-concentration step, and surface nanostructuring & chemical modification. The integration of the label-free detection sensors with an on-line automated sample handling and a wireless communication system will yield a best-in-class biosensor platform for robust, specific and sensitive detection of EDCs and PAHs in difficult operating conditions. To validate the RADAR biosensor the consortium will test the biosensors in fresh and marine water, in fish farms, and in food products such as fish, fruit juices, and milk. Through their contacts in these industries, the partners will evaluate the performance of the biosensors in such environments, analyzing a representative number of samples and reporting on the stability, ruggedness and accuracy of the sensors used under laboratory and real test conditions. This project is expected to have a high economic impact, since our cost-effective sensor could find a worldwide distribution in most food production and water testing lines as supported by Agilent Technologies Inc.",Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and pollutants,FP7,31 December 2014,01 January 2011,2926127.0 RADDEL,Consejo Superior De Investigaciones Científicas (CSIC),health,"The consortium RADDEL (RADioactivity DELivery) has a research-based approach for the training of the new generation of scientists in the development of novel functional nanomaterials . A well structured training program will be provided with a balanced combination of local and network-wide training through secondments, joint network meetings, workshops, schools, industrial training and the final network conference. The research program focuses on the design, synthesis, characterisation, pharmacological studies and dosimetry calculations of nanocapsules that seal in their interior radioactive materials for biomedical applications in the areas of cancer diagnosis and therapy. After sealing the chosen radionuclides, the external walls of the nanocapsules will be decorated with biomolecules to render them biocompatible and for targeting purposes. In a recent study we have recently observed that these nanocapsules allow the delivery of unprecedented radiodosage and remain stable for extended periods thus guaranteeing essentially zero leakage of the radionuclides. Surface functionalisation of these nanocapsules offers versatility towards modulation of tissue biodistribution of the radioemitting crystals in a manner determined by the nanocapsule that delivers them. The delivery of radioactivity takes place through the walls of nanocapsules (carbon) and release of the encapsulated radionuclides is therefore not needed and certainly not desired. The present research objectives go beyond the-state-of-the art in the field and innovative products and solutions are expected.",Nanocapsules for targeted delivery of radioactivity,FP7,31 January 2016,01 February 2012,3849760.0 RADSIMOS,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"This research proposal aims to study the correlation between the defects generated by the radiation and the degradation observed in the macroscopic characteristics of microelectronic devices, following this strategy, we will be able to develop and obtain new materials and devices more resistant to radiation. The research activities are divided in two branches. The first objective is to investigate the radiation hardening of silicon detectors, to be used especially in High Energy Physics experiments. Our interest will mainly focus on the evaluation of the radiation hardness of standard and oxygen-enriched High Resistivity silicon. The analysis will be performed on both, test structures and full-size radiation detectors. The main specific potential advantages and drawbacks in detectors processing with oxygen-rich material will be investigated. Based on the analysis of the experimental outcome, as well as on technological and electrical simulation results, it is expected to improve the process technology, as well as the silicon radiation detectors design. Our second objective is to study the radiation effects on the performance and reliability of thin gate dielectrics and CMOS transistors, which are essential for the correct circuits operation in high radiation environments. Our interest will focus on the mechanisms that lead to the radiation-induced degradation of the gate dielectric layers subjected to high energy irradiations. Especial emphasis will be given to the electrical stability and post irradiation response of the generated damage. The thermal and electrical annealing kinetics of the radiation-induced damage will be determined. It is expected to elaborate degradation models enabling prediction of device performance and reliability in radiation-harsh environments, as well as Guidelines for hardening the technologies.",Radiation Effects Study for Development of Radiation-Hard Silicon Detectors and CMOS Devices,FP6,20 March 2006,21 March 2005,40000.0 RAINBOW,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"Indium nitride is a new narrow gap semiconductor (<0.7 eV), which alloys with GaN (3.5 eV) and AlN (6.2 eV) will allow the spectral range from telecom to hard UV wavelengths to be covered. This narrow band gap makes InN an exciting material from which to develop highest efficiency solar cells. Moreover, due to an electron mobility of around 4000 cm2/Vs and very high saturation velocities, InN is an ideal material for the development of high electron mobility devices capable of operating in the Terahertz range. To ensure the production of reliable commercial devices, rigorous fundamental research is required to understand the layer growth mechanisms and optimize material properties. In RAINBOW, academic and industrial consortium, the theoretical work will encompass modelling of the atomic structure and properties of the material from empirical potentials to ab initio techniques. Experiments will provide correlated structural, electronic, optical and chemical information from the nano to the macroscopic scale. In a closely concerted effort, we will determine the best conditions for the growth of highest quality InN and In rich (In,Ga,Al)N alloys by the main growth techniques (MOVPE, PAMBE,HVPE ). Under the supervision of world leading experts, numerous young researchers will directly benefit from this interdisciplinary and multisectorial research and training effort. The young researchers involved in this programme will also learn to manage research and industrial projects.",High quality Material and intrinsic Properties of InN and indium rich Nitride Alloys - (The RAINBOW ITN),FP7,30 September 2012,01 October 2008,4778667.0 RAMAN,Dublin Institute of Technology,health,"Raman spectroscopy is a powerful tool for probing biochemical changes in situ at tissue level. The vibrational profile can provide invaluable molecular details for medical diagnosis and disease prognosis. Important technological as well as health and safety considerations, however, limits its clinical application, as spontaneous Raman is a relatively weak effect and high laser powers are required for rapid screening. Surface-enhanced Raman scattering (SERS) makes is possible to probe single molecules adsorbed onto a silver or gold nanoparticle, greatly enhancing the sensitivity of spontaneous Raman and therefore potentially significantly reducing screening times. However, the SERS sensitivity from spherical gold nanoparticles is still insufficient to detect trace biomolecules and/or the interaction between biomolecules, which may be overcome through using novel shape nanomaterials as SERS substrates for the improvement of the bio-detection limit. Recently, Pegylated gold nanoprisms (AuNPrs) have been successfully employed as signal amplifiers in multimodal in vivo imaging of cancer cells, and therefore pose a great potential for Raman spectroscopy as well. Excellent biocompatibility properties are known for Pegylated AuNPrs, with side lengths of 120nm and thicknesses of 10nm. They absorb strongly at a wavelength of 830 nm, with co-efficients of up to 37 µg.mL-1•OD-1, a wavelength within the tissue transparency window, promising deep penetration in vivo This project will explore the optimisation of Pegylated AuNPrs for surface enhancement of the Raman signal (SERS)of their local cellular environment for probing disease in vitro and ulimately in vivo. Lung cancer is the most common cause of death from cancer in the EU and is therefore chosen as a model for the development of a Raman based rapid screening technique for early detection of disease.",Gold Nanoprisms as Raman Signal Amplifiers for Bioimaging of Lung Cancer,FP7,31 March 2015,01 April 2013,254637.0 RAMP,University of Padua * Università degli Studi di Padova,information and communications technology,"Information processing in classical ‘von Neumann’ architectures is less efficient compared to biological counterparts when dealing with ill-posed problems and noisy data. The reason is that the biological brain is configured differently and the key is its evolving structure, where connectivity elements between individual neurons, the synapses, undergo ‘birth’ and ‘death’ as well as strengthening and weakening through a selection process, reconfiguring neuronal connectivity in a self-organizing manner and allowing the networked population of neuronal processors to adapt motor and behavioural responses to the ever changing environment. Artificial neural networks in the form of software run on conventional ‘von Neumann’ computers appear incomparable to the biological systems in terms of speed, energy efficiency, adaptability and robustness. The challenge is to propose a ‘physical’ neural network where elements overcome this deficiency by merging data storage and processing into single electronic devices and by self-organizing and reconfiguring connectivity. Along this route, we aim to create a new biohybrid architecture of natural and artificial neurons endowed with plasticity properties. Communication between artificial and natural worlds will be established through new nano- and microtransducers allowing direct electrical interfacing of a network of neurons in culture to an artificial CMOS-based counterpart. Adaptation properties of the artificial network will rely on memristive nanoelectronic devices with synaptic-like plasticity and on activity-dependent rearrangement of neuronal connectivity. As such, the biohybrid system will provide new and unique adaptive, self-organizing and evolving properties deriving from the fusion of natural and artificial neuronal elements into a new plastic entity and will represent a fundamental step towards the development of novel brain-inspired computing architectures as well as ‘intelligent’ autonomous systems and prostheses",Real neurons-nanoelectronics Architecture with Memristive Plasticity,FP7,10 July 2018,11 January 2013,2068000.0 RAQUIN,London School of Economics and Political Science,information and communications technology,"The main scientific objective of this project is the development of schemes for scalable and robust quantum computing in periodic lattice structures which are feasible with current or short-term experimental technology. We plan to achieve this by using decoherence free subspaces in ensembles of atoms stored in periodic traps and examine methods for performing robust single and two qubit gates in these subspaces. We will study implementations based on strong atomic interactions (e.g. controllable molecular interactions) and on flexible interactions mediated by a cavity field. These schemes are extended to quantum networks and we will check their suitability for implementation in concrete experimental setups. Such proposals have become realistic due to recent experimental breakthroughs in manipulating and controlling atoms in optical lattices and the networks we will investigate should allow to build special purpose quantum computers which can be used e.g. for small specific tasks in quantum cryptography or for simulations of more complicated quantum systems. The work on this project will boost my career and allow me to pursue my aim of becoming an independent researcher in the field of quantum information processing. I will be able to establish a number of new collaborations with groups in Oxford where an interdisciplinary research collaboration will link me furthermore to most of the current quantum information research inside the UK. In addition, the existing collaboration between the University of Oxford and the University of Innsbruck which both have centres for quantum computing would be strengthened and I would benefit from links to both centres in the future. A successful completion of the project will have significant impact on the field and thus contributes to enhance excellence and reputation of European research.",Robust atomic quantum information processing networks in periodic lattice structures,FP6,30 November 2006,01 December 2004,152810.0 RAVEN10,Technical University of Madrid * Universidad Politécnica de Madrid,information and communications technology,"Many of the future applications that will drive the need for greater performance are naturally highly parallel and process massive data sets, where individual point results are of less interest than aggregate statistics or behavior. Examples include statistical machine learning, rich human-machine interfaces, and physical modeling for games and virtual worlds. In this project, the goal is to develop new highly parallel many-core architectures that exploit the attributes of these parallel, error-tolerant applications to tolerate variability in a projected future 11nm process at very low supply voltages and hence attain large gains in energy efficiency. An integrated cross-disciplinary research program is proposed cutting across software, architecture, and circuits. The architecture is named Raven (Resilient Architecture with Vector-thread ExecutioN). Each Raven core is a single vector-thread lane, with an independent control processor and a vector-thread execution engine, and hundreds of such lanes will be designed to fit in the area budget. Cores with similar characteristics will be identified through the pre-characterization phase and will be grouped to form clusters. Their delay and performance will be notified to control processor, so that it can perform dynamic scheduling of tasks to cores with a goal of achieving extreme energy efficiency. Additionally, hardware delay and performance monitors will be embedded in logic so that the process variability can be controlled through immediate dynamic reconfiguration. The greatest benefits will accrue from recognizing the optimization opportunities that the individual research ideas enable across the software/architecture/circuits stack. The applicant will not only acquire multidisciplinary training through the execution of the proposed project, but will also be guided by the experts who have gained worldwide recognition in their field and will have the opportunity to collaborate with leading electronic companies.",DESIGN OF EXTREMELY ENERGY-EFFICIENT MULTI-CORE PROCESSOR IN NANOSCALE CMOS FOR MEDIA PROCESSING IN PORTABLE DEVICES,FP7,06 June 2016,07 January 2011,230027.2 RBCE-GENODIAGNOSENS,Rovira i Virgili University * Universitat Rovira i Virgili,health,"The overall objective of RBCE-GenoDiagnoSens is to exploit breakthroughs at the confluences of micro-, nano- and bio-technologies to initiate the creation of a low-cost minimally-invasive intelligent diagnosis system using a nanotechnology-based device for the early detection of DNA biomarkers involved in breast cancer, especially found in circulating tumour cells (CTCs). The device will consist of an array of nano-biosensors for the consecutive RNA/DNA analysis of cancer cells. The advantages of the exploited biosensors for RNA/DNA analysis are their sensitivity, their inherent selectivity, their versatility and their cost effectiveness. Death from cancer is usually due to metastases that are formed by hematogenic or lymphatogenic spread of cancer cells from the primary disease site. Fortunately, only a subset of these persist and have the ability to form vascularised macro metastases. Therefore, the quantification and characterisation of circulating tumour cell mRNAs in order to define the metastatic potential is of clinical relevance and may prove valuable for monitoring disease progression and patients response to treatment, and assessing the risk for metastasis or recurrence. With prognostic implications, the quantities of mRNA markers in blood could indicate the stage of cancer progression and the need for more intensive therapeutic intervention to better the outcome of cancer patients. In the frame of the RBCE-GenoDiagnoSens, the leading research scientist will design, taylor and test the optimum surface chemistry for the functionalisation and operation of the nano-biosensors, following his established expertise in the field, while the host institution will provide the complementary knowledge and training in microfabrication, DNA expertise, mass-manufacturing, regulations and commercialisation consideration as routes for the researcher to establish his own autonomy and his progression to become a successful principal investigator within the European Union",Recuring breast cancer early genetic diagnostic on a chip,FP7,28 February 2010,01 March 2008,159166.0 RDCVF,National Institute of Health and Medical Research * Institut National de la Santé et de la Recherche Médicale (INSERM),health,"The discovery of RdCVF (Rod-derived Cone Viability Factor) has provided a clue to understanding the secondary loss of cone photoreceptors (and of central and light-adapted vision) following the degeneration of rod photoreceptors as a consequence of mutations expressed only in rods in most cases of rod-cone degenerations (or retinitis pigmentosa : RP). In two different rodent models of RP, intraocular administration of RdCVF increased significantly cone survival and function. Given the unparalleled genetic heterogeneity of retinal dystrophies, including RP, the delivery of RdCVF appears as a promising, mutation independent strategy for preserving central vision, even at late stages of the disease, opening a wide window for neuroprotection. RdCVF, discovered by team 1, and developed by team 5, has been granted by the EMEA and FDA the Orphan Status. Reaching the stage of phase I/II trials with RdCVF protein therapy in RP implies several key preclinical milestones: 1) the production of GMP grade proteins and their functional validation in in vitro and in vivo assays, 2) pharmacokinetic and pharmacodynamic studies determining, the dosage, half life, site of injection of the protein, while 3) toxicology studies will be performed in normal and mutant mice and rats, and in monkeys. In parallel, based on the knowledge gained by partner 1 on tryparedoxins (the family of RdCVF) and on RdCVF sequence and paralogs, attempts will be made to 4) optimize the therapeutic protein. In order to reduce the injected dose and to provide a steady level of RdCVF, innovative delivery systems such as nanoparticules will be developed. These steps, conducted by renown academic partners in the fields of neuroprotection and toxicology, experienced industrials and subcontractants, will lead to a proof of safety and concept in advanced RP. This may provide a novel, widely applicable approach to an untreatable blinding condition, while hinting towards extension to other neurodegenerative diseases.",Rod-derived Cone Viability Factor,FP7,28 February 2013,01 March 2010,2623333.0 RE-ACT,Universiteit Twente * Twente University,health,"The objectve of Re-ACT is to establish the foundations for a long-term research effort in integrated active nanophotonic devices based on the use of rare-earth doped double tungstate crystalline materials. Re-ACT puts together several disruptive leading edge technologies in an innovative manner to solve several important problems that are hindering the complete integration of nanophotonic circuits. Research areas that will be investigated include plasmonic propagation with gain, gain assisted all-optical processing, integrated optical isolators and the use of plasmonic resonant effects for novel on-chip sensing devices and nanolasers. It is expected that the results obtained in Re-ACT will lead to several breakthroughs that will enable the realization of long searched fully integrated active nanophotonic devices. The possibility to integrate as much functionality on the chip as desired, with almost unlimited bandwidth and with very low power consumption will open the door to new concepts in telecommunications, computing and personal entertainment that will revolutionize the way human communications will take place. Several breakthroughs in diagnostics, medical imaging and environmental monitoring are also expected. In our ageing society, there is an increasing need for technologies enabling non-invasive medical diagnostics and preventive medicine. Environmental care will benefit from the deployment of distributed networks of very small and sensitive sensors that will help monitoring our fragile resources. Water could become a scarce resource in the future and the importance of having safe water is increasingly becoming a priority. These realizations will be enabled thanks to the development of novel miniaturized microspectrometers and networks of biosensors coupled with arrays of integrated low power consumption nanolasers.",Novel active nanophotonic devices in rare-earth doped double tungstates,FP7,31 July 2015,01 August 2011,100000.0 READNA,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"The REvolutionary Approaches and Devices for Nucleic Acid analysis -READNA -consortium is composed of researchers from 10 academic institutions, 5 SMEs and 3 large companies. The goals of the READNA consortium are to revolutionize nucleic acid analysis methods, by 1) improving elements necessary to use the currently emerging generation of nucleic acid sequencers in a meaningful and accessible way, 2) providing methods that allow in situ nucleic acid analysis and methods capable of selectively characterizing mutant DNA in a high background of wildtype DNA, 3) combining RNA and DNA analysis in a single analytical device, 4) providing technology to efficiently analyze DNA methylation (genome-wide, with high resolution and in its long-range context), 5) implementing novel concepts for high-throughput HLA-screening, 6) developing fully integrated solutions for mutational screening of small target regions (such as for screening newborns for cystic fibrosis mutations), 7) developing a device for screening multiple target regions with high accuracy, and 8) implementing strategies for effective and high-resolution genotyping of copy number variations. An important part of READNA is dedicated to the development of the next generation of nucleic analysis devices on individual DNA molecules by stretching out nucleic acid molecules in nanosystems, using alpha-hemolysing nanopores and carbon nanotubes. These approaches will benefit from improved interrogation and detection strategies which we will develop. Our methods and devices will boost the possibilities of genetic research by closing in on the target of 1000 Euros for the sequence of a complete human genome, while at the same time leading a revolution in cost-effective, non-invasive early screening for diseases such as cancer.",REvolutionary Approaches and Devices for Nucleic Acid Analysis,FP7,30 November 2012,01 June 2008,1.1992319E7 READRITENANO,University of Cambridge,information and communications technology,"The applied science of addressing memory elements. Ferromagnetic and ferroelectric materials are sometimes used as data storage media to encode information. I propose to investigate thin film heterostructure nanodevices in which these two ground states compete and cooperate to create extra degrees of freedom in the read-write process. Specifically, I am looking to encode information electrically and read it magnetically. This is because it is easy to write electrically and read magnetically, but the reverse statements are not true. I will therefore combine the best aspects of the existing technologies, namely, the electric-write process of FRAM, and the non-volatility and magnetic-read processes of disc-drives and MRAM. Two oxide materials systems will be explored by growing epitaxial films using pulsed laser deposition: 1)Multiferroic materials. These are single phase and ferromagnetic, ferroelectric and ferroelastic. It may be possible to address them both electrically and magnetically. 2)Ferromagnetic/ferroelectric heterostructures. By electrically writing information into a ferroelectric layer that displays strong piezoelectric effects, it will be possible to generate elastic strains that can be used to write magnetic information into an adjacent ferromagnetic layer. Nanoscale proof-of-principle devices will be fabricated in the new Cambridge Nanotechnology Centre from films of the above materials systems. A scientific study of mesoscopic texture will be simultaneously undertaken in the materials described above. There is now widespread interest in textures that extend over intermediate (sub micron) length scales. I will study such textures using the electron microscopy suite of the host institute. Exploitation. The research is novel becuase the materials systems required to co-host coupled ferromagnetic and ferroelectric order are in their infancy. I hope to develop such materials and take out patents once#",Electric-read magnetic-write nanodevices,FP6,31 August 2006,01 September 2004,159046.0 REALISE,University College Cork,information and communications technology,"The REALISE project aims (i) to develop an atomically controlled deposition process for high-k oxide layers as an enabling technology for a variety of innovative integrated circuit technologies and (ii) to advance fundamental knowledge of materials functionality in the areas of thin film growth, oxide-semiconductor interfaces, surface-precursor reactions and atomic-scale characterisation of dielectrics. These two global aims will be achieved by collaborative research across a range of disciplines. No satisfactory process exists for depositing rare earth oxide films as high-k dielectrics at present. The process that is the subject of this project is atomic layer deposition (ALD), the leading technology for deposition of nanometre-scale films. The project aims to overcome the current difficulties and limitations of rare earth oxide ALD, through project goals that span the entire process: design, synthesis, scale-up and testing of suitable precursors; characterisation of film quality and optimisation of deposition parameters. To investigate the functionality of rare earth oxides as dielectrics and to show the utility of ALD in the electronics industry, further goals of REALISE are: deposition onto variously-prepared semiconductor substrates (Si, Ge); high-resolution characterisation of the semiconductor-oxide interface; scale-up of new ALD process to industrially-sized Si wafers; testing of dielectric in capacitors for innovative memory (DRAM, NVM) and wireless (decoupling for RF) applications. REALISE thus brings together unique expertise to achieve urgently-needed materials integration solutions for the European semiconductor industry.",Rare Earth Oxide Atomic Layer Deposition for Innovation in Electronics,FP6,30 September 2009,01 March 2006,2631323.0 REALITY,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,As miniaturization of the CMOS technology advances designers will have to deal with increased variability and changing performance of devices. Intrinsic variability of devices which begins to be visible in 65nm devices already will become much more significant in smaller technologies. Soon it will not be possible to design systems using current methods and techniques.,Reliable and Variability tolerant System-on-a-chip Design in More-Moore Technologies,FP7,08 July 2012,01 January 2008,0.0 REALTIMEIMAGING,Istanbul Sehir University * İstanbul Şehir Üniversitesi,photonics,"This project describes the four years re-integration program to facilitate a successful and continuous integration of Dr. Ozdal Boyraz's research in the real time optical detection and imaging field into the EU's needs, and to support Dr. Ozdal Boyraz's re-integration to research and educational activities at the Istanbul Sehir University and in EU. Spectroscopy and imaging of biological samples with ultra high resolution are subjects of growing interest. With the advent of nanotechnology, metamaterials, and plasmonic devices the sub wavelength resolution is now a concrete possibility in microscopy. However, the current state of the art imaging tools resort to time averaged analysis to extract high resolution information from a single point at the expense of loosing information on transients and correlated events in the proximity of the focal spot. The proposed research aims to develop a real time system using time-space-wavelength encoded mesh type optical grids to capture the image in a 2-D plane in a single shot. Instead of resorting to imaging with point by point scanning via nano positioning stages, broadband coherent optical sources covering the area of interest are used to capture information from a multiple coordinates by encoding them on a designated color and a time slot to avoid scanning. The design and development of near-field focusing plates is incorporated into the project for subwavelength focusing to mitigate the resolution bottleneck and achieve sub wavelength microscopy in a single shot measurement. Space wavelength mapping has been utilized extensively for arbitrary waveform generation and microwave antenna design. The impact of this technology in bio detection and imaging is yet to be explored in subwavelength domain. Design and fabrications are compatible with conventional CMOS technology and attractive for low cost production.",Real Time Imaging with Near Field Focusing Plates,FP7,01 December 2015,01 December 2010,100000.0 REAMOFUN,University of Limerick,energy,"A key research area for composite materials is the addition of nanoscale constituents to provide multi-functionality, i.e. materials capable of meeting multiple demands, such as structural, electrical, thermal, and energy storage. Such materials are termed 'multifunctional nanocomposites'. Over the past decade, much research has been performed on carbon nanotube (CNT)-based nanocomposites, and it has been demonstrated that CNTs can enhance the mechanical properties of composites, as well as form conductive networks. More recently, research on graphene-nanoplatelet (GNP) nanocomposites has been undertaken and indications are that GNPs are superior to CNTs for transferring mechanical load. Inspired by the capability of CNTs to form conductive networks and graphene to transfer load, this project will examine hybrid CNT/GNP-reinforced thermoset matrix nanocomposites by large-scale Molecular Dynamics simulations. The objective of this interdisciplinary project is to understand the synergistic mechanisms of GNPs and CNTs in improving mechanical, electrical and thermal properties of hybrid nanocomposites, as demonstrated by a few experiments to date, and to investigate how to design nanocomposites to get optimal performance. In the process, modelling of the in-situ polymerisation of hybrid nanocomposites will be carried out for the first time, and mechanical, electrical and thermal properties of resulting nanocomposites will be predicted. The applicant has published extensively on multi-functional composites and modelling of in-situ polymerisation of polymers, while the Host has 20 years' experience in composites research in Europe, and is seeking to expand an existing highly-fruitful collaboration with EPFL, Switzerland, in this area. The EU composite community will benefit from the applicant's unique knowledge and expertise, and the development of an extensible simulation tool for predictive modelling and optimisation of multifunctional thermoset nanocomposites.",Reactive Molecular Modelling of Multi-Functional Hybrid Graphene/CNT Nanocomposites,FP7,14 October 2015,15 October 2013,254637.0 REBRAKE,Freni Brembo SpA,health,"Particulates, also known under the name of particulate matter (PM), are fine particles or soot. Particulate matter is frequently classified according to its size, i.e. PM10, PM2.5 and PM0.1 for particulates with an aerodynamic diameter D smaller than, respectively, 10 µm, 2.5 µm and 0.1 µm. PM represent an hazard for human health. Very coarse particles (D > 10 µm) are generally filtered in the nose and throat via cilia and mucus. Coarse particles (2.5 µm < D < 10 µm) can settle in the bronchi and lungs. Fine particles (0.1 µm < D < 2, 5 µm) can easily penetrate into the lungs gas exchange regions, and they might cause vascular inflammation related diseases and possibly lung cancer. Ultrafine particles (D < 0.1 µm) or nanoparticles might be even more dangerous, as they can reach intimate structure of tissues and organs and act as nucleations sites for cancer and degenerative pathologies.. Despite the emissions of PM2.5 and PM10 decreased by 16% and 21 respectively between 1999 and 2009, PM limits were exceeded widely across the EU area, a quite discouraging result. Whilst exhaust gases in the road transport are monitored and object of the European directives, less is known about the particulates originating from the wear of e.g. brakes and tyres. A recent study for the city of London regarding 2011 and future 2015 PM emissions, estimated a consistent increase of the PM wear emissions (brakes and tyres) with respect to the overall PM emissions: from 35% to 47% for PM10 and from 40% to 55% for PM2.5 The REBRAKE ultimate and tangible objectives aims at: i) at least 50% particulate matter (PM10) mass reduction from brake wear, in compliance with the EU2020 thematic strategy of 47% reduction of particulate matter by 2020; ii) deeper comprehension of the physical and chemical phenomena underlying the brake wear process, including higher comprehension and analysis of characteristics coarse, fine and UFP particles.",50% Reduction of Brake Wear Particulate Matter,FP7,28 February 2017,01 March 2013,2061716.0 RECATABI,Chemical Institute of Sarria * Institut Quimic de Sarriá,health,"Heart failure is the end-stage of many cardiovascular diseases, but the leading cause is the presence of a large scar due acute to myocardial infarction. Current therapeutic treatments under development consist in cellular cardiomyoplasty where myocardial cells or stem cells are implanted alone or encapsulated in natural scaffolds (collagens) and grafted onto infarcted ventricles with the hope that cells will contribute to the generation of new myocardial tissue. This approach seems to have a beneficial effect although it is not completely understood and optimized, yet. Thus, the urgent need of better therapeutic platforms is imminent. In view of this, we created a small interdisciplinary consortium (RECATABI) with experts in areas such as material sciences, tissue engineering, stem cell technologies and clinical cardiovascular research. RECATABI will integrate and synergise their capacities in order to obtain a novel clinical platform to regenerate necrotic ischemic tissues after cardiac infarct with a simple one-time patch technology application. The consortium will accomplish this by fabricating nanoscale engineered biomaterials and scaffolds that will match the exact biomechanical and biophysical requirements of the implanted tissue. In addition, the construct may induce rapid vascularization to ensure tissue remodelling and regeneration into a newly functional myocardium. The regenerative capacity of the implants loaded with pre-adapted cells (biomechanically and biophysically trained) will be assessed in small (rodents) and large (sheep) animal models.",Regeneration of Cardiac Tissue Assisted by Bioactive Implants,FP7,31 December 2012,01 January 2010,2328302.0 RECRYST,University of Copenhagen * Københavns Universitet,construction,"Calcite (CaCO3) plays a role in many public and industrial regimes that are critical for the health and economic well-being of society, but in many cases, a lack of understanding of the fundamental physical and chemical properties controlling calcite growth and dissolution translates to direct problems or to inefficiency in water treatment processes. A common method for removing toxic trace-metal contamination during water treatment is to add lime (Ca(OH)2 or CaO). Trace metals are trapped in growing calcite as Ca combines with CO3 from the water. However, production of lime requires burning of calcite, often in the form of limestone or chalk. This emits CO2, and though some CO2 is consumed during water treatment, considerable energy is required for lime production, which also contributes to the atmospheric carbon load. If a method could be developed to treat water directly with natural calcite, without first converting it to lime, considerable energy could be saved and CO2 emissions could be reduced. We will investigate methods to alter the surface properties of chalk, to make it more effective at trapping trace metals. Our approach is to promote Ostwald ripening, the natural process where small particles dissolve to provide material for growth of larger particles. The growing calcite traps trace-metals, removing them from the water. To achieve this, we will apply nano-technological methods for characterising particle surfaces and use a bio-technological approach to develop environmentally friendly enzymes that can degrade the organic coatings on chalk particles, which are known to inhibit natural recrystallisation. The Science and Technology results will lead to improved treatment processes for clean drinking water, and a decreased need for lime production with less consequent emissions of CO2, thus significantly improving energy efficiency and environment sustainability.",Improving water treatment processes through chalk recrystallisation,FP6,31 July 2010,01 August 2008,182403.0 RECYVAL-NANO,"L'Urederra, Fundación para el Desarrollo Tecnológico y Social",environment,"Waste Electrical and Electronic Equipment is considered to increase drastically in the coming decades. WEEE contains considerable quantities of valuable components used in high-tech applications that currently are not recycled. Europe needs to improve and develop Recovery, Recycling and Reuse of critical materials in order to avoid the dependency on imports, high prices and risk of supply imposed by countries owning mineral reserves. RECYVAL-NANO project will develop an innovative recycling process for recovery and reuse of indium, yttrium and neodymium metals from Flat Panels Displays (FPD), one of the most growing waste sources. The project will be addressed not only to the recovery of these critical elements, but also the recycling process developed will result in the direct extraction of metallorganic precursors for direct reuse in the production of high added value nanoparticles that is ITO, Y2O3:Eu3+ and Nd-Fe-B. The project will develop an integral study of the recycling process, starting with logistic issues of the waste collection, optimising mechanical sorting technologies and developing innovative ones for the recovery and concentration of smaller fractions containing indium, yttrium and neodymium, developing simplified solvent extraction routes based on tailored chemical extraction agents able to extract a 95 % of the key metal in a metallorganic extracted solutions, and using these extracted solutions as precursors in the direct production of advanced nanoparticles. RECYVAL-NANO will validate the recycling process developed through the construction, optimisation and demonstration of full pilot lines for mechanical recycling of FPDs (500 kg/h) and hydrometallurgical metal recovery processes (500 g/h). Finally, the demonstration of the superior performance application of ITO, Y2O3:Eu3+ and Nd-Fe-B nanoparticles in electronic applications of transparent conductors, LEDs and permanent magnets respectively will complete the entire cycle of the project.","Development of recovery processes for recycling of valuable components from FPDs (In, Y, Nd) for the production of high added value NPs",FP7,11 June 2018,12 January 2012,3200097.0 REDDSTAR,National University of Ireland Galway,health,"50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines and present challenging management issues for clinicians. Stromal Stem Cells (SSC) are a mixed population of plastic-adherent (PA) cells isolated from adult bone marrow. PA-SSC secrete potent immunosuppressive and angiogenic proteins and over 100 clinical trials are testing PA-SSC in 40 distinct autoimmune and ischemic diseases. Notably, preclinical studies show a single intravenous administration of un-modified PA-SSC can control rodent hyperglycaemia, prompting 10 recent clinical safety studies in diabetic patients. REDDSTAR will comprehensively examine if SSC can safely repair all 6 damaged tissues and control glycaemia in three different species. To facilitate this we identified an antibody (S2) that prospectively isolates comparable, equivalent S2+SSC from human, rat, mouse and rabbit marrow, enabling testing of pure S2+/- SSC and mixed PA-SSC from each species for the first time. Furthermore, separation of PA-SSC into S2+ and S2- fractions reveal functionally distinct populations. REDDSTAR partners have collectively developed five distinct clinically-relevant in vivo models of the 6 key diabetic complications. We will assess if S2+, S2- and PA-SSC exert differing control of glycaemia and tissue repair in each model. Finally, REDDSTAR partners are developing the first benchtop GMP-grade nanosorter, enabling clinical purification of S2+ and S2- SSC for human safety trials. We will dissect how S2+ and S2- SSC simultaneously repair tissue damage and maintain glycaemic control, an effect not observed with any current therapy.",Repair of Diabetic Damage by Stromal Cell Administration,FP7,31 October 2015,01 November 2012,5894387.0 REFREEPERMAG,National Centre of Scientific Research Demokritos Institute of Microelectronics,environment,"This proposal aims at developing a new generation of novel materials for high performance permanent magnets (PM) with energy product 60 kJ/m3 <(BH)max < 160 kJ/m3, which do not contain any rare-earths or platinum. To achieve this objective two strategies will be used: a) exploitation of shape anisotropy of high magnetic moment materials produced in the form of high-aspect-ratio (>5) nanostructures by environmentally friendly synthesis methods and b) using high-throughput (HT) thin film synthesis and characterization techniques to identify new PM candidate phases. The first strategy, through the control of the nanostructure will lead to a factor of 4 increase of the coercivity (over conventional Alnico) . The second strategy will use (HT) methods to screen hundreds of possible compositions and synthesis conditions. Investigations will focus on promising candidate materials of the type {Fe-Co}-X-Y (X = other 3d or 4d metals and Y= B,C,P or N) and Heusler alloys of the type X2YZ (where X is usually Fe, Co, Ni, Cu; Y other transition metals, most often Mn; and Z a group-B element (Al, Ga, Ge, Sn...). High Ms materials that can be stabilized in tetragonal or hexagonal structures by epitaxial growth on selected substrates are the goal with magnetic anisotropies in excess of 107 ergs/cm3.This range covers a wide field of applications and represents a sizeable market fraction of over 100 M€. All research will be performed taking into consideration the critical issues of toxicology and sustainability of the full life cycle of the materials from production to recycling. The consortium will generate breakthroughs to re-establish the EU as a leader in the science, technology and commercialization of this very important class of materials with a wide range of applications, helping to decrease our dependence on raw materials from abroad providing a positive socioeconomic impact and increased employability of young European scientists.",RARE EARTH FREE PERMANENT MAGNETS,FP7,04 June 2017,05 January 2012,3841400.0 REGMINA,"Institute of Chemistry, Technology and Metallurgy",photonics,"The Centre of Microelectronic Technologies and Single Crystals, a department within the Belgrade-based Institute of Chemistry, technology and Metallurgy, is the only Serbian institution fully dedicated to research in the fields of microsystems and nanosystems. It is oriented to applied research of different solid-state sensors and detectors, microelectromechanical (MEMS) and microoptoelectromechanical (MOEMS) structures and nanostructures for a wide range of practical applications, including industry, environmental protection, health protection, etc. The Centre covers all stages of a research cycle, starting from the fundamental theory, proceeding with simulation, micro- or nanofabrication and characterization and ending with a finished device. Our vision is to boost the Centre into a regional centre of excellence in sensor micro- and nanosystems, enabling it to fully integrate into the EU research, at the same time ensuring a sustainable growth of its research resources and wider coverage of topics. To this purpose a reinforcement of labs is necessary, continual improvement of knowledge base and skills through training and increased mobility of research personnel, networking and joint research with EU teams, but also enhancement of the Centre's visibility through knowledge dissemination to both experts and the general public. The Centre already possesses a number of advanced technologies and a large expertise and know-how in numerous fields of semiconductor science, planar technology including photolithography, chemical engineering, thin film technologies, micromachining and other procedures specific for microsystem and nanosystem technologies. In this moment the teams of the Centre are engaged in a number of modern topics, including microcantilever-based nanosensors, cavity-enhanced optical detectors and novel sensors utilizing photonic bandgap materials and electromagnetic metamaterials.",Reinforcement of Regional Microsystems and Nanosystems Centre,FP7,29 February 2012,01 May 2008,799996.0 REPLIXCEL,University of Manchester,health,"The project seeks to create a novel, efficacious vaccine against influenza virus; a new type of synthetic vaccine readily adaptable to meet whichever influenza virus subtype may arise. A new generation of RNA-replicon technology will be employed combined with nanoparticles and innovative adjuvants for targeting of dendritic cells and efficient antigen expression. The consortium comprises two SMEs and two academic institutions each having unique and patented expertise such as replicon technology, nanoparticle technology, adjuvant chemistry, and surface modification chemistry to attach targeting moieties. As a highly interdisciplinary project, extensive exchange of knowledge between the project partners will be required in particular between product focused SMEs (nanoparticles, adjuvants) and technology excellence of academic institutions (replicon technology, surface modification chemistry).",Highly efficient new generation synthetic RNA-replicon based vaccine,FP7,31 March 2014,01 April 2010,2591172.0 RESCOR,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"Spectroscopy is one of the fundamental tool in condensed matter physics, materials science and nanoscience. Resonant spectroscopies, like Resonant Inelastic X-ray Scattering (RIXS) and angle resolved Resonant PhotoEmission Spectroscopy (RPES), offer invaluable information on the system under investigation, being able to probe different types of excitations, from electron-hole pairs (excitons), to spin-flip, to collective excitations, to orbital and magnetic excitations. This proposal aims at improving the present theoretical description of these two powerful spectroscopies, in order to gain a better understanding of moderately correlated systems and, on the long term, to offer a future tool to describe resonant spectra of strongly correlated systems. The proposal relies on the combination of efforts between the candidate (whose experience is mainly in X-ray spectroscopy) and the community working in low energy excitations mainly via many body perturbation theory. Such joint effort is necessary given the difficult task of being able to describe both deep core level excitations and low energy excitations, with finite momentum transfer, which can both give signatures of the many body physics in the system. The project is mainly devoted to the improvement in the description of RIXS, in particular in the extension of the first (ab-initio) attempts done recently by collaborators of the host group to the complicated case of indirect RIXS. On the side, the candidate aims at making her previous work on RPES available to the vast community working in photoemission, creating an interface with a well established and well structured tool widely used for interpreting X-ray results. The impact of the outcomes of such proposal are huge: it will connect theoretical communities working in different energy ranges, and it will represent an invaluable tool for interpreting the huge amount of experimental output on resonant spectrscopies from European synchrotron radiation facilities.",Exploiting RESonant processes to understand CORrelations,FP7,11 May 2016,12 May 2014,194046.0 RESOLUTION,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),information and communications technology,"RESOLUTION aims at developing of a wireless three-dimensional (3-D) local positioning system with measurement accuracy in the centimetre regime and real-time ability. A novel frequency modulated continuous wave (FMCW) radar principle with pulsed active reflector is employed. This advanced local position radar (ALPR) will be implemented on basis of common WLAN systems. Due to its high data rate capabilities and large potential bandwidth, the 802.11a/n standard allocated around 5.5 GHz is applied. Special care is put on the reconfigurability by efficiently using inherent synergies between the WLAN system and the ALPR approach. Thus, the additional costs compared to standard WLAN systems are reduced to a minimum. To allow multifunctional tasks, highly integrated system on chip (SoC) frontends will be designed on advanced CMOS or BiCMOS technology. Smart power and adaptive performance control will be applied to minimise the power consumption according to application needs. In order to enhance the performance and coverage range, the transceiver features adaptive antenna combining in the radio frequency (RF) receiver. Compared to conventional approaches performing adaptive combining in the baseband, this approach significantly decreases the power consumption, size and costs, since the number of multiple components is reduced to a minimum. Because of the high 3-D resolution and real-time ability, which can even be achieved in indoor environments with strong multipath effects and fading, novel local positioning applications, e.g. for smart factories, robotics, guiding, object tracking and augmented reality are possible leading to a large economic potential. Market analyses and preparations for a market launch are performed to allow a successful exploitation of the results. The consortium consists of 1 large enterprise, 3 small/medium size enterprises, 1 research institute and 4 universities from 4 EU countries and 2 associated EU countries.",Reconfigurable Systems for Mobile Local Communication and Positioning,FP6,31 January 2009,31 January 2006,2950000.0 RESPSPATDISP,University of the Basque Country * Universidad del País Vasco / Euskal Herriko Unibertsitatea,information and communications technology,"The global objective of the project is to develop a theoretical framework for the first-principles description of the macroscopic electromagnetic response of solids with a full and accurate account of the spatial dispersion and memory effects. The new scheme will be applied to study two fundamental properties of extended systems: the natural optical activity and the magnetoelectric effect in crystals of technological relevance, such as multiferroics and topological insulators. We should state that at present there is no theory able to model the frequency-dependent response of extended systems with the full account of spatial dispersion. The response of these systems to static fields has been widely studied in recent years and among others has given rise to the development of what is known as the modern theory of polarisation. The present project aims at the extension of those theories to the time-domain and will certainly have a big impact in the fields of condensed matter, material science, nano- and bioscience. The outcome of the project would be delivered to the whole scientific community as part of the Octopus project that aims to have a fully versatile free (GNU license) code able to describe the time-dependent electron-ion dynamics of finite and extended systems to arbitrary intense and time-dependent electromagnetic perturbations.",First-principles theory of spatial dispersion in electromagnetic response of solids: Applications to natural optical activity and magnetoelectric effect,FP7,05 July 2017,06 January 2013,0.0 RESSEEPE,Integrated Environmental Solutions Ltd.,energy,"RESEEPE will bring together design and decision making tools, innovative building fabric manufacturers and a strong demonstration programme to demonstrate the improved building performance through retrofitting. The core idea of the RESSEEPE project is to technically advance, adapt, demonstrate and assess a number of innovative retrofit technologies. Reductions in the area of 50% will be achieved in terms of energy consumption .A systemic process will be also implemented that will allow the selection of the best possible retrofiting mix, customised to the needs of the particular building.. Several remarkable innovative technologies and materials will be integrated in the retrofitting process: - Envelope Retrofitting: Ventilated Facades, Aerogel-based Superinsulating mortar, Wooden Insulating Wall Panel and VIP Panel - Integration of RES: PV Energy, Thermal Collectors - Energy Storage Systems: Thermal storage and PCMs - Nanotechnologies and smart materials: EC/PV Windows - ICT: Strategies at building and district level - Intelligent Building Controls: HVAC systems The RESSEEPE framework will be validated and refined by a strong demonstration programme, envisaging the renovation of 102.000 square meters of public buildings, arriving to a total renovation of 205.000 square meters that will be deployed in the following years. The estimated average of energy consumption in the renovated demo sites, on final energy, will be 66 kWh/m2•year, representing a 63% of reduction in energy consumption compared to the current situation. CO2 emissions will be 48,15 kg/m2•year, corresponding to more than 60 % of reduction. The total emissions avoided by the demo sites will be 2257 tCO2/year. Associated investment costs to building renovation are expected to represent a maximum of 19% on average of the total costs of building an equivalent new building in the same location. On average, the return on investment will be around 7,6 years.",REtrofitting Solutions and Services for the enhancement of Energy Efficiency in Public Edification,FP7,30 June 2017,01 July 2013,8800000.0 RETINA,EADS Deutschland GmbH Corporate Research Center Germany,information and communications technology,"The project aims at developing a reliable and low cost solution for agile beamsteering in Ku- or Ka-band onboard mobile platforms, such as planes and satellites. It is based on the global concept called ReflectArray and the industrial implementation is clearly a lower cost alternative compared to active antennas. It will allow a high data rate connection between the mobile platforms and therefore enabling: - Live TV and Internet onboard to every passenger - Internet flight monitoring using the plane-satellite link The first objective with its associated services of the web will improve passengers' comfort and support quasi uninterrupted daily services for the citizen, whether for personal or professional purposes. It is also envisioned that this system could bring an added value to ATM functions, whatever the distances from the platforms to the airport areas, by participating to in-flight monitoring of flight parameters or for safety and security (live video) related purposes to generate early warnings and advised external help to the crew. Technically, the spatial steering of the beam is based on coherent combining of elementary EM cells radiation. Such a concept has been validated since some years now by using today's low cost PIN diodes for the basic key function, the phase shifter. Although successfully applied, it still has major inconveniences that outweigh by far the initial low cost of the diodes. Therefore, two alternative solutions will be considered in parallel within the project. - High-power handling RF-MEMS technologies - High-power handling ferroelectric materials They are considered by the consortium as the best technical alternatives for phase shifters up to Ka-band today and are foreseen to levelup the performances while keeping the costs at the lowest level. The project will lead research in the two domains and has a decisive milestone to choose the most suitable technology for the final reflect array approach.","Reliable, tuneable and inexpensive antennas by collective fabrication processes",FP6,29 February 2008,01 February 2005,3170000.0 RETROGRADE SIGNALING,Tel Aviv University,health,"Neuron cell death and synapse disruption seen during aging and in neurodegenerative diseases is a non-cell-autonomous process and involve a multi system progression. As neurons are highly polarized cells with very long axons, in order to remain healthy and function properly, they depend on accurate and efficient long-distance communication mechanisms. My long-term goal is to elucidate the molecular mechanisms for long distance signaling between neurons and their environment. I will combine state-of-the-art multidisciplinary approaches such as single molecule live imaging techniques, nanofluid-co-culture chambers and differential proteomics approaches on mouse model systems to address basic questions on the roles that retrograde signaling between muscle, glia and neurons play in cell survival and synapse stability. We will develop a unique in vitro microfluidic platform with motor neuron cell bodies on one-side and glia/muscle cells on the other side, which will allow us to distinguish local versus long distance signaling mechanisms and monitor retrograde axonal transport, as well as to manipulate retrograde signaling pathway regulating NMJ maintenance and cell survival. Three approaches will be taken: 1. In vitro and in vivo live cell imaging. 2. Specific cell biology. 3. Functional proteomics. Using model systems for aging and for neurodegenerative diseases will allow us to characterize the vital signaling mechanisms for NMJ/synapse maintenance and neuronal survival, as well as reveal novel stress factors that lead to nerve degeneration and cell death. Using the above strategies will provide a clearer picture of how cells use spatial localization and transport to regulate cell survival and synapse stability. The research will generate novel insights into neurodegenerative mechanisms and, ultimately, provide a molecular basis for new drugs as well as delivery methods to treat a range of neurodegenerative diseases.",Molecular Mechanisms of Neurodegeneration,FP7,28 February 2015,01 March 2011,100000.0 RFMIFICS,Queen's University Belfast,health,"This proposal aims at further strengthening the current line of the applicant's research in the area of nontraditional energy sources and structured reactors. Novel and challenging reactor concepts and technologies are proposed for newly emerging liquid phase catalytic processes for, amongst others, fine chemicals and pharmaceuticals synthesis. Catalytic processes in the liquid phase are crucial in the manufacturing of fine and specialty chemicals. It is widely accepted that the activity of a solid catalyst suspended in a liquid phase can benefit greatly from the use of smaller catalyst particles to avoid mass-transfer limitations. However, the difficulties in recovering small particles from the reaction mixture severely circumvent their industrial applications. To overcome the above drawbacks, the separation of suspended magnetic catalyst bodies from the liquid system using an external magnetic field is proposed. Functionalized magnetic bimetallic nanoparticles are leading candidates for catalytic applications as a vector for magnetic guidance. Their appclication will provide reactors and processes for synthetic routes and high-value added products with optimal space-time yields, minimum waste production, minimum energy consumption, and minimum operating costs. Two novel reactor concepts are proposed in this ERC starting grant program with the aim to develop and demonstrate continuous flow reactors, viz. (1) the RF-heated reactor where catalytically active magnetic nanoparticles are hold in the reactor by an external magnetic field while being heated, and (2) the micro-flow through reactor for magnetic NP manipulation, where mixing in laminar flow is improved by quadrupolar actuation created by a quadrupolar micro magnet arrangement along the channel.",RF-enhanced Microprocessing for Fine Chemicals Synthesis using Catalysts Supported on Magnetic Nanoparticles,FP7,31 December 2015,01 September 2011,1242000.0 RHIZO,University of Copenhagen * Københavns Universitet,environment,"In the past decades, forest productivity was maximized by the use of large quantities of fertilizers and pesticides. These chemicals are produced by complex processes, which consume high levels of energy from fossil fuels and emit large amounts of CO2. The secondary effects of the chemicals include increased ground and surface water pollution and soil degradation in all forested ecosystems in Europe and other parts of the world. Part of the problem is a lack of fundamental understanding about mineral-derived nutrient dynamics in forests, their weathering release, storage and transport in soils and roots to maintain high, but sustainable, production of high quality wood products. If practices could be developed to enhance natural processes for nutrient acquisition and transport, pesticide and fertilizer use could be reduced, energy could be saved, CO2 emission decreased, and environmental sustainability insured. Root-microbe-mineral interactions in the rhizosphere regulate mineral-derived nutrient acquisition and transport to plant roots. I will investigate these interactions to improve understanding of rhizospheric biofilms formed in symbiotic associations. My research sofar shows that these biofilms enhance silicates mineral weathering, sequester atmospheric CO2 in the hydrosphere, and decrease the loss of mineral-derived nutrients to ground and surface water. To expand on this, I will examine the chemical and physical structure of the root-microbe-mineral interface, using stat-of-the-art nano-scale techniques combined with microbiological and biogeochemical approaches under natural and controlled growth conditions. I will also characterize the biofilms under elevated CO2 levels. The science and technology results gained from this project will contribute directly the the scientific community and to the society through improvements in commercial tree production, forest health and sustainability under the increased CO2 levels.","Rhizospheric biofilms at root-microbe-mineral interfaces: A key to improve productivity, sustainability and CO2 balance in forests",FP7,06 June 2014,07 January 2010,218119.79 RIGIDITY SENSING,Tel Aviv University,health,"Recent studies show that the rigidity of the extracellular matrix is a critical determinant of cell growth, differentiation, and death. Cells sense rigidity via integrin adhesions and respond by changing their morphology, signaling, and gene expression patterns. Irregular rigidity signals or defective responses to appropriate rigidity signals underlie many medical disorders. This is especially evident in cancer, where the ability of cells to detect differences in matrix rigidity is fundamentally altered. Despite the importance of mechanosensing of matrix rigidity, findings in this field have been mainly phenomenological, and at the moment we still don't know how rigidity sensing occurs. Active rigidity sensing involves development of traction forces on integrin adhesions, yet how cells develop forces, and how these forces are used to sense and transmit rigidity signals are both unknown. This grant is focused on analyses of the steps in building the machinery used by fibroblasts to sense and transmit rigidity signals. During the outgoing phase of the studies the applicant will use a combination of nanofabricated surfaces with integrin ligands, elastic micropillars that allow measuring forces, and super-resolution microscopy to define the critical steps in the assembly of integrin adhesions and to determine which proteins are essential for force production. The return phase of the studies will focus on investigating the signaling events downstream of rigidity sensing using biophysical measurements of the interaction kinetics of signaling molecules with integrin adhesions. The proposed studies will provide a detailed spatiotemporal description of the critical components and pathways of mechanosensing of matrix rigidity, and will help explain the underlying mechanisms involved in rigidity sensing during important processes such as differentiation or cancer.",Mechanisms of Cellular Rigidity Sensing,FP7,29 February 2016,01 March 2013,264711.0 RIMANA,IMS Nanofabrication AG,information and communications technology,"The STREP proposal Radical Innovation Maskless Nanolithography (RIMANA) aims to research and develop a key maskless nano-patterning technology for low to medium volume production, essential for the semiconductor industry and emerging nanotechnology industry. RIMANA is driven by two global industrial needs: � An ML2 tool for short run and low to medium volume leading edge device manufacturers (Logic, ASIC, Silicon Foundries) � A fast Mask Writer for the leading edge high volume device manufacturers (MPU, DRAM, Logic) Both global industrial needs are addressed by the proposed RIMANA project with the following overall S/T objectives and work plans: � Concept and realisation of a new, highly-innovative compact APS (Programmable Aperture Plate System), including high-speed electronics with the ability to generate a massive parallelisation of electron beams for the 32nm technology node and beyond � Concept and realization of Data Path improvements to achieve higher data rates � Design and generation of test benches to demonstrate sub-32nm node ML2 high throughput capabilities in resist � Brainstorm of results with perspectives for potential industrial realisation The key challenges will be to explore and develop essential elements for the massive parallelisation of electron-beams and electron-optics, retaining ultimate resolution down to the nanometre scale, while minimising throughput-resolution trade-offs. The project will be carried out by a strong and diversified team from industry, academia and acclaimed European research institutes, under the leadership of IMS Nanofabrication GmbH, an SME with extensive experience in cutting-edge charged particle nanofabrication reseach and technology. RIMANA is harmonised completely with the FP6 strategic objective IST � NMP-3. In particular, RIMANA addresses the need for 'maskless nano-patterning for low to medium volume production for the 32 nm node and beyond'.",Radical Innovation Maskless Nanolithography,FP6,30 September 2008,30 September 2005,3437168.0 RISKBRIDGE,Nederlandse Organisatie voor Toegepast- Natuurwetenschappelijk Onderzoek (TNO) * Netherlands Organisation for Applied Scientific Research,health,"This proposal aims to develop an integrative risk governance model connecting risk assessment - management and -communication based on a resilience and discursive approach. The project takes: ?an open project architecture rather than a specific model as starting point; ?policy learning as the central mode of operation, allowing for input across different science fields, geographical boundaries and science-policy interfaces; ?cases related to complex risk fields where the agreement of risk government approaches is limited. ?An approach with six partners and 30 members (scientists and policymakers) The project is structured in three parts. In a preparatory phase the key partners exchange insights on risk governance practice, and transform this into a framework for risk governance learning. In the empirical work phase, six risk fields take centre stage. It concerns: Biotechnology/stem cells, Radioactive waste, Nanotechnology, Climate change, Sediments and Electromagnetic fields. For each risk field, a learning trajectory will be organized, in which 3 workshops form the focal points. Ws 1 focuses on learning about best practices across disciplines and participants within each risk field. Ws 2 ?designs? a best science-policy interface for each risk field. Ws 3 compares, analyzes and learns across risk fields resulting in an accepted governance model including transdisciplinary lessons and input from scientists and policy makers. In the integration phase the results from the workshops and risk fields will be combined an integrated in a report (book) recommending how to handle complex and emerging risks in the form of a process scheme approach. The results of the project are validated and disseminated in a conference on Risk governance. A ?Heritage? work package make sure concepts and particularly the created science-practitioner network, can be structurally liaised with and embedded in institutions such as IRGC or SRA.","Risk-BRidge (Building Robust, Integrative interDisciplinary, Governance Models for Emerging and Existing risks)",FP6,30 June 2009,01 July 2006,776105.0 RNAI IN HSC VIA NP,Tel Aviv University,health,"RNA interference (RNAi) is a ubiquitous and highly specific, endogenous, evolutionarily conserved mechanism of gene silencing. Since the discovery that RNAi occurs in mammalian cells, RNAi has emerged as a powerful tool for elucidating gene function and identifying potential drug targets. Harnessing RNAi holds enormous promise for therapeutic use for diseases that have proven difficult to treat with conventional drugs. RNAi can also be exogenously activated either by transducing cells with vectors to express small hairpin RNAs (shRNA) or by introducing already processed short double-stranded RNAs (siRNAs) into the cytoplasm of cells. To realize the potential of siRNAs for in vivo drug discovery and therapy there is a need to overcome the considerable hurdle of intracellular delivery across the plasma membrane. siRNAs are not taken up into most cells in vitro in the absence of a transfection reagent. For many cells, mixing siRNAs at nanomolar concentrations with a lipid transfection can efficiently induce gene silencing. However, some important cells, including primary lymphocytes and hematopoietic stem cells, remain highly resistant to lipid transfection schemes. We have recently developed nanoparticles that target integrin b7 that is expressed on leukocytes involved in gut inflammation. Using this approach, we revealed cyclin D1 to be a potential anti-inflammatory target in inflammatory bowel diseases. The goal of this proposal is to explore the hypothesis that targeted nanoparticles entrapping siRNAs can be developed to induce in vivo gene silencing in hematopoietic stem cells. Using this strategy, we plan to identify key genes responsible for pluripotent hematopoietic stem cells (pHSC) self-renewal properties. This will provide a powerful technique to investigate the contribution of individual genes in maintaining the phenotypic and functional properties of pHSC, and ultimately may provide a way to improve engraftment during bone marrow transplantation.",Delivery of siRNAs to hematopoietic stem cells using nanoparticles,FP7,31 December 2013,01 January 2010,100000.0 ROADTOIPS,The University of Edinburgh,health,"Induced pluripotent stem cells (iPSCs) are expected to have an enormous impact on medical research. However, the efficiency of reprogramming is still low and far from routine. Nevertheless, reprogramming with defined factors, Oct4, Sox2, Klf4 and c-Myc, is not a random event. Cells positive for SSEA-1, a marker of undifferentiated mouse ES cells (ESC), appear from cells which have lost the fibroblast marker Thy-1, prior to acquiring other pluripotent markers, e.g. Oct4, Nanog. Similarly, TRA-1-60 positive fully reprogrammed human iPSCs appear from SSEA-4 positive populations. Based on these observations, I hypothesize that there are essential ordered stages that the cells must undergo as they are directed toward pluripotency. To explore this hypothesis, I plan to perform three projects: 1. Identifying gene expression signatures during the successful reprogramming process. 2. Investigating serial changes of reprogramming factor binding, chromatin modifications and chromatin structure on the route to a pluripotent state. 3. Functional analysis of the candidate gene(s) identified for successful reprogramming. Based on my latest publication in Nature, I have developed an original highly efficient reprogramming system, in which almost all cells differentiated by retinoic acid treatment generate iPSCs by day 12 post reprogramming factor induction. The homogenous culture allowed by this system enables the unique execution of the objectives above, and for the first time will shed light on the molecular mechanisms of the reprogramming process. Accurate and more informed understanding of these ordered processes will allow derivation of strategies to improve the reprogramming technology.",Dissection of molecular signature transformation during the process of pluripotency induction,FP7,30 November 2015,01 December 2010,1359000.0 ROBOCON,University of Rome Tor Vergata * Università degli Studi di Roma Tor Vergata,photonics,"Enormous progress in material engineering, research tools and methods very frequently lead to revisiting the traditional topics of Condensed Matter Physics and their study under the very original and unexpected view-point. In the current project we propose to consider the possibility and realization of such textbook phenomena as Bose-Einstein condensation in three, on first glance different systems: 1. Carbon-based systems: Graphite, Graphene and Nanotubes 2. Exciton-Polariton excitations in semiconductors 3. Perovskite Oxides close to Metal-Insulator transition. that, according to the very recent studies demonstrate the very common feature: the Bose statistic of current (mass) carriers and tendency to form the condensed superconducting or/and superflluid state at high temperatures. It is this feature that unify the leading experts on these materials in the proposed Multidisciplinary Marie Curie IRSES project ROBOCON which has the final objective to understand the realization of BEC phenomena on the experimental and theoretical level in the proposed systems and elaborate practical recommendations for their further applications in High-Tech industry: polariton lasers for CD and DVD players and laser printers, novel Carbon- and Oxide- based microelectronics for computer RAM and CPU devices etc. Basing on this common subject we created the distributed consortium (network) of partner institutions, located in EU (France, UK, Italy) and Eligible Third Countries (Morocco, Brazil). Each of them has its own specialization and related with others by virtue of already existing bilateral collaborative links. In course of the project we suppose to amplify and order these collaborations and create the new links between partners under central common idea of study and optimization of mechanisms and realization of BEC. Series bilateral visits, training workshops and meetings are previewed for this purpose.",Routes to Bose-Einstein Condensation at Room Temperature,FP7,31 December 2012,01 January 2009,459000.0 ROBUSPIC,AMI Semiconductor Belgium BVBA,information and communications technology,"Smart power circuits and technologies contribute in a unique way to the realization of the system-on-chip concept by combining digital logic with analogue signal processing and power and high voltage switching. The main objective of this project is to enable a robust design of smart power circuits leading to a first-time-right design with built-in reliability and thus avoiding very costly over-dimensioning. To achieve this ambitious goal, compact models will be built that accurately describe power device operation including extensions to verify safe-operating area conditions. The devices to be modelled include the lateral DMOS, vertical DMOS and LIGBT fabricated in bulk silicon and power devices realized in advanced SOI technology. Model extensions are planned for device ageing due to hot-carrier injection, statistics due process variations, device matching and layout effects such as large area closed-cell matrices. An important feature will be an accurate description of the internal device temperature plus a coupling to package thermal models and EMC modelling. The final goal is to achieve a system level design flow for smart-power SoC using complex transistor level simulations or generated black-box models. Full smart power circuits will be simulated with the new design flow and models will be assessed and calibrated against experimental measurements. The gain in performance and robustness will be quantified.The project therefore aims at providing the EC 'power' industrial community with new, highly robust tools to design and characterize smart power devices and circuits. This will strengthen and significantly advance ECs position as a fast growing, world supplier of smart power technologies. Design and fabrication of highly reliable and efficient Smart Power circuits is one of the most important strategic ways to reduce drastically energy losses in power systems by ensuring optimal energy conversion at all times.",Robust Mixed-Signal Design Methodologies for Smart Power ICs,FP6,31 March 2007,30 November 2003,2600000.0 ROCOCO,University of Manchester,health,"We aim to offer to science a molecular scale mechanism for communication and control. Using stereochemical information and conformational control as the mechanism by which that information is transmitted and processed, we take inspiration from the phenomenon of allostery in biology, and will put to dynamic use a set of conformationally controlled foldamer structures. We will use these structures to convey information over multi-nanometre distances, allowing control of chemical function from a remote site. By embedding the foldamers into membranes, we will control chemistry (eg catalytic activity) within an artificial vesicle by communicating information through the chemically impermeable phospholipid bilayer. To achieve our aim we will synthesise oligomeric and polymeric compounds with well-defined helical conformations, and use a stereochemical influence located at one terminus to induce a conformational preference (for the left or the right handed form of the helix) which is relayed to a site many nanometres distant. Precedent suggests that by employing polymeric structures we will achieve control even over micrometre scales. Simple but powerful new techniques will quantify the remote (on a molecular scale) transmission of information by NMR, circular dichroism spectrophotometry and/or fluorescence. The result of the information relay will be a detectable change in chemical reactivity or binding properties and one aim will be to vastly increase, by orders of magnitude, the distance over which remote stereochemical control is possible (from the current 2.5 nm to the order of >100 nm). The feature which distinguishes biology from chemistry is information, and in particular the ability to encode and process information using molecular interactions. Our project will take a step towards the development of designed chemical structures which can mimic, using far simpler molecules, the function of biological communication systems.",CONFORMATIONAL COMMUNICATION AND CONTROL,FP7,31 March 2016,01 April 2011,2426106.0 ROD-SOL,Leibniz Institute of Photonic Technology * Institut für Photonische Technologien,energy,"Thin film solar cells, based on non-toxic, abundant and air-stable silicon (Si) will probably, based on forecasts, dominate the photovoltaic market in the future and thus replace bulk Si from its leading position. This prognosis is fostered by the strong cost reduction potential due to highly effective materials utilization at low energy consumption. However, thin film Si suffers from inherently small grains, which limits efficiencies to ~10% due to carrier recombination at grain boundaries. A radical innovation of the Si thin film materials synthesis route is needed to circumvent this problem. ROD_SOL aims at the synthesis of Si nano-rods, densely packed at sufficiently large diameters (few 100 nm's) and lengths (>1µm for sufficient carrier absorption in indirect semiconductors) directly on cheap substrates like glass or flexible metal foils. The idea is to grow Si nano-rods from the gas phase that are inherently defect free, with a wrapped around pn-junction that bares the potential to decouple absorption of light from charge transport by allowing lateral diffusion of minority carriers to the pn-junction, which is at most a few hundred nm away, rather than a few µm as in conventional thin film solar cells. That way, efficiencies as in bulk Si are expectable, however, with the advantage that the 'nano-rod carpet' layer, is at most a few µm thick. A 'nano-rod carpet' that thin shows a strongly increased optical absorption. Thus, the 'nano-rod carpet' is not only the active solar cell element but at the same time its own light trapping structure. For synthesis of the nano-rods, development of suitable contact materials and characterization of physical and structural properties four experienced research institutes have joined forces. Despite the fundamental materials research to be in focus, three companies joined the consortium to directly test and implement the novel materials and processes in a well proven, industrially viable thin film solar cell concept.",All-inorganic nano-rod based thin-film solarcells on glass,FP7,31 December 2011,01 January 2009,2699842.0 RODIN,Chalmers University of Technology * Chalmers Tekniska Högskola,information and communications technology,"The RODIN-project, which seamlessly integrates experimental, industrial and theoretical work, is organized around the concept of suspended single-and few-layer graphene nanostructures and annealed diamond-like carbon films. These structures are ideal for accessing and engineering the intrinsic material properties of graphene. In particular we will focus on engineering and measuring the mechanical and electromechanical properties. This will be done through sculpting of the suspended structures to desired shapes as well as using thermal post-processing methods. Initially, the graphene will be obtained using standard prototype techniques such as exfoliation and plasma assisted chemical vapor deposition. The main goal of the project, one that requires going beyond the current state of the art in multiple areas and has rapid and substantial industrial impact, is the fabrication and demonstration of a tunable graphene resonator with electronic readout. The performance of a mechanical resonator depends sensitively on materials quality, which makes it an ideal test application for a materials-oriented project.",Suspended Graphene Nanostructures,FP7,09 June 2015,10 January 2010,2894280.0 ROLLED,Technical Research Centre of Finland Ltd. * Valtion Teknillinen Tutkimuskeskus VTT Oy,information and communications technology,"Organic light emitting devices (OLED) are developing rapidly towards high performance displays. However, they also have huge potential for new low cost applications e.g. in packaging and printing industry. Even simple low resolution segment displays, displays with low pixel count or just fixed pattern light sources offer a wide area of new applications. To reach the cost level required for this application field the production of the devices must be transferred to the low cost roll-to-roll processes, which can be integrated to the conventional printing and packaging processes used in industry. On the contrary to the typical semiconductor light sources, OLEDs have potential to be processed in continuous roll-to-roll processes. This requires selection and modification of suitable materials, effective patterning technologies, development of the manufacturing processes and improved encapsulation technologies. This development will be done keeping all the time the application, the potential and the required performance in mind. The project's goal is the development of a cost-effective, volume-scale, roll-to-roll manufacturing technology for the realization of flexible OLED devices with arbitrary size and shape pixels and displays on web. These technologies are developed in order to achieve a well understanding of the production process structure. Technologies are tested and demonstrated in the manufacturing process of demonstrator displays.",Roll-to-roll manufacturing technology for flexible OLED devices and arbitrary size and shape displays,FP6,31 July 2008,31 July 2004,2249005.0 ROMA,Warsaw University of Technology * Politechnika Warszawska,information and communications technology,"MicroElectroMechanical Systems, or MEMS, represent an extraordinary technology that promises to transform whole industries and drive the next technological revolution. These devices can replace bulky actuators and sensors with micrometer ¬scale equivalents that can be produced in large quantities by silicon micromachining. This reduces cost, bulk, weight and power consumption while increasing performance, production volume, and func¬tionality by orders of magnitude. MEMS improved functionalities and potential capabilities have brought in range many different application fields, including optical communications, medicine, guidance and navigation systems, RF devices, weapons systems, biological and chemical agent detection, and data storage. Because the field of commercial MEMS is still in its infancy, there is nevertheless an important issue for MEMS which still requires advanced research, i.e. MEMS reliability. Reliability is a particular challenge for MEMS because directly influences the acceptance, competitively and reputation of a technology. Many promising MEMS applications are to be found in safety critical systems and in harsh environments, where the cost of failure might be catastrophic. MEMS technology is evolving rapidly with the introduction of new processes, materials, and structural geometries. This brings many new failure mechanisms, which are poorly understood compared to the well known failure mechanisms for common integrated circuits. The grand objective of this Project is to develop and apply reliability procedure for micro-actuators during their chip-production and their long-term characterisation by the development of measurement and data analysis procedures, the proposition of novel optical instrumentation in experimental measurement for reliability, the development of hybrid numerical-experimental methodologies to increase the understanding of performance, and to support modelling of failure modes.",Reliability of microfabricated actuators,FP6,31 August 2006,01 September 2005,0.0 ROMANS,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The purpose of this PoC project is to develop a prototype of portable, highly sensitive and low cost technology for point-of care detection of inflammatory diseases biomarkers. At DTU Nanotech we have developed a completely new technology which holds a great potential to become, in a short period, an extremely useful tool for small medical facilities, family doctors, and chronically ill patients. The core readout element is represented, as in the HERMES project, by an optical pickup head, as used in CD, DVD-ROM or BLU-RAY, which embeds in a single optical path both a laser source and a high-resolution photodetector. By measuring how the light is scattered by magnetic nano-particles actuated by an external AC field we have demonstrated that it is possible to detect low concentration of analytes present in the sample. The key feature of our invention is that blood preconcentration and analyte readout are integrated into the same magnetic-based operations, leading to a compact, low-cost and user-friendly device. Doctors will benefit from our technology which allows performing multiple analyses without relying on centralized laboratories. A fast technology capable to detect multiple parameters would for example allow patient screening at the family doctors' offices, or would allow chronic diseases patients to be monitored without the need of regularly going to the hospital. The scope of the project is both to provide a benchmarked prototype and to identify the best approach to commercialize the invention. The PoC grant will provide the instruments for understanding the low-cost point-of-care market more deeply, in order to start addressing as soon as possible the challenges of breaking through a complex market such as human diagnostics. Thanks to the intrinsic low-cost of the machine components, several cycles of production/testing/evaluation are expected to be performed, facilitating a constant and fast improvement of our platform development and testing.",Rotating Opto-Magnetic Analysis System,FP7,31 December 2014,01 January 2014,149833.0 ROOTHZ,University of Salamanca * Universidad de Salamanca,health,"ROOTHz project addresses the bottleneck of Terahertz Science and Technology, where the fabrica-tion of room temperature, continuous wave, compact, tunable and powerful sources (at low cost, if possible) is the prime challenge. THz radiation (also called T-rays), whose frequency range lies between microwaves and infrared light in the electromagnetic spectrum, opens the possibility for a new imaging and spectroscopic technology with a broad range of applications, from medical diagnostic (without the damage pro-duced by ionizing radiation such as X-rays), industrial quality control or security-screening tools. T rays sources must be obtained at the limits of electronics from one side and optical systems from the other, resulting in a lack of efficient and practical radiation sources. In ROOTHz we propose to exploit THz Gunn oscillations in novel (narrow and wide bandgap) semiconductor nanodevices, which have been predicted by simulations but not experimentally confirmed yet. We aim at the fabrication not only of solid state emitters but also detectors at THz frequencies by exploiting the properties of both wide and narrow bandgap semiconductors and the advantages pro-vided by the use of novel device architectures such as slot-diodes and rectifying nano diodes (nano-channels with broken symmetry so called self-switching diodes, SSDs). The simplicity of the tech-nological process used for the fabrication of these diodes is remarkable, since it only involves the etching of insulating trenches or recess lines on a semiconductor surface (a single step of high reso-lution lithography). Furthermore, their particular geometry allows providing Gunn oscillations overcoming the classical frequency limit (around 300GHz). The fabrication of THz detectors with the same technology will complement this objective and allow the demonstration of a simple THz detection/emission subsystem at the conclusion of the project.",Semiconductor Nanodevices for Room temperature THz Emission and Detection,FP7,30 June 2013,01 January 2010,1567109.0 RPSII,University of Cambridge,energy,"Photocatalytic water splitting is an attractive means of efficiently converting solar energy into a storable hydrogen fuel, offering a clean and renewable source of energy that can replace fossil fuel. In this study, the Photosystem II (PSII) enzyme is employed as a biological catalyst in important proof-of-principle studies to establish the basic principles behind emerging artificial photosynthetic devices for efficient light-driven water splitting. Currently, the maximal output of PSII-based photocatalytic water splitting systems is capped by a number of factors, most significantly the non-ideal 'wiring' of the enzymes to the electrode giving rise to inefficient electron transfer. The present Marie Curie International Incoming Fellowship (IIF) project proposes to enhance the performance of benchmark PSII-based photocatalytic systems by 'rewiring' the electron transfer from the bio-catalyst to the anode to eliminate inefficient steps, and hence establish new maximal outputs achievable by such systems. This will be achieved by directed immobilisation of the PSII to the anode, followed by the inhibition of redox events in the electron flow pathway to bypass the rate-limiting step. Moreover, current photocatatlyic water splitting systems rely on expensive rare-earth components which are ultimately non-sustainable and uneconomical for use in future photocatalytic devices. In this study, newly accessible nano-structured earth-abundant substrates will be investigated as electrode material to ultimately encourage the development of more sustainable systems for photocatalytic water splitting.",Re-wiring of photosystem II enzymes to metal-oxide electrodes in artificial photosynthetic devices for enhanced photocatalytic water splitting performance,FP7,10 March 2015,11 March 2013,221606.0 RTNNANO,Lancaster University,information and communications technology,"The proposed RTN will link the activities of world-leading groups working on the fundamentals of nanoelectronics, which will ultimately
revolutionise the electronics industry. By maximising the potential of our scientific expertise, human resources, infrastructures and funding,
the proposed RTN will enhance the EU's basic understanding of future nanoscale devices, increase the efficiency of pre-competitive
research, educate the next generation of students and researchers, reduce fragmentation, increase the awareness of industry and the general public and underpin new developments in standards and metrology.
We shall have impact on the field, not only by generating new knowledge, training early-stage researchers and effectively disseminating this
knowledge, but also by helping to restructure the European landscape of training activities in nanoelectronics. By creating a new RTN which will act as a focus for fundamental nanoelectronics research, we shall also attract the best international scientists to Europe.
This proposal is based on an existing 10-node RTN and past TMR and HCM networks. During the past 30 months the RTN has produced
over 220 joint publications (over 50 of which were in Physical Review Letters, Nature or Europhysics Letters) and trained over 20 E.U.-
funded pre- and postdoctoral researchers in the theory of nanoscale dynamics. By working together we have achieved a level of visibility
unattainable by a single team and have made major advances ahead of competitors in the United States and Japan. The forefront of the field
of nanoscale physics is moving ahead at a breathtaking pace and the new research to be undertaken will sustain Europe's leading position in the fundamentals of nanoelectronics. The new 12-node network involves world-recognised leaders in this field and is ideally placed to tackle leading-edge problems.
The research objectives of the proposed RTN are expected to generate major breakthroughs and will help to #",Fundamentals of nanoelectronics,FP6,30 April 2008,01 May 2004,1748013.0 S-CH PERTURBATION,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),environment,"The proposed project provide a comprehensive study of the chemical response of a host grain on volumetric changes connected with phase transition of inclusions in ultra-high-pressure rocks. The main goal is to investigate the effects of stress induced diffusion in a solid of uniform composition by means of an integrated approach including combination of conventional petrology methods with material science analytical techniques and numerical approaches. Though the interplay between stress and diffusion has been described in material science, the chemical response on stress induced during the solid phase transition has not been studied in geo-materials so far. The proposed hierarchic structure of observations on a wide range of length scales, from the thin section scale down to the nanometer scale will thus give a new and profound insight into the interplay of the kinetic processes, which control the microstructure and chemical evolution during solid phase transformation. The detailed analysis of these small scale processes in ultra high pressure natural samples will also offer valuable data for modeling larger scale processes in Earth interior. Moreover, as the diffusional relaxation modifies elastic state of the material which affects the mechanical properties of the phase, explicit formulation of relaxation kinetics and mass transport for natural, complex chemical system on small scale will provide insights relevant to problems in material science, ceramic industry as well as to radioactive waste disposal programs.",Stress and chemical perturbation around mineral inclusions,FP7,04 June 2015,05 January 2011,177601.6 S-PULSE,Leibniz Institute of Photonic Technology * Institut für Photonische Technologien,information and communications technology,"The proposed Support Action S-PULSE aims to prepare Superconducting Electronics (SE) for the technology generation beyond the CMOS scaling limits ('beyond CMOS'). Scaling laws in CMOS technology indicate that some concepts cannot be simply extrapolated, and new physical effects that have been negligible up to now, have to be taken into account in the future. Due to the total different physical base in SE, it never had a scaling law, and quantum limits define the ultimate speed. This provides already demonstrated logic operation speed above 100 GHz with typically power dissipation of 1 aJ per logic operation with a 1 µm feature size metal based process. The European activities in SE are currently coordinated by the non-profit Society FLUXONICS e.V., a SCENET initiative under FP6 for a dynamic technology platform in SE. As a major outcome of this network, a circuit foundry for SE was established, a cell library was made available and a first roadmap was drawn up in the field. S-PULSE supports joint efforts of European academic and industrial groups in the superconducting technologies field. The action is to strengthen the vital link between research and development on the one _x000d_",Shrink-Path of Ultra-Low Power Superconducting Electronics,FP7,06 June 2012,01 January 2008,0.0 S-SCIL,Rubotherm GmbH,health,"The aim of S-SCIL is the development and testing of new standards to measure the selective sorption for multigas application. This technology, which is not yet available, brings huge advantages for various kinds of chemical, pharmaceutical, environmental, food and energy processing. These new standards can be used to characterise the substances which are used to perform the process (porous solids, (nano- )particles, polymers, liquids) concerning their selective behaviour in gas-mixtures as well as to investigate the process itself in terms of temperature, pressure and composition. In addition, the main single gas sorption measuring standards, including the multi gas ones developed by this project, will be investigated and adapted for the characterisation and investigation of pure and multigas processing based on ionic liquids. Targets are: investigation of several methods for gas analysis concerning their potential for combined sorption measurements in a wide range of temperature and pressure; development of a simple and economic sensor combination for a wide range of temperature and pressure; combination of gas analysis modules with two high end sorption measuring apparatus, one combined gravimetric / volumetric for measurements in static atmospheres and one gravimetric for measurements in a forced flow through; design and manufacture of a prototype of a commercial instrument based on the development previously done; adaptation and testing of sorption measuring standards, including the new ones to characterize ionic liquids and investigate chemical processing realized by using ionic liquids.",Development and Testing of new Standards for Sorption Measurement and Characterisation of Ionic Liquids (S-SCIL),FP6,31 March 2007,01 January 2005,781000.0 S3,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The objective of S3 is developing breakthrough technologies in gas sensing that will provide higher sensitivity and selectivity at reduced cost. This objective will be pursued by bringing together excellence and complementary skills of ropean Union and Russian groups. Enhanced sensitivity and selectivity will enable toxic and explosive gases to be detected against a background of air constituents and ubiquitous air contaminants. This task will be pursued by studying sensors and sensing principles based on semiconductor nanowires (NWs) molecularly engineered, in terms of doping level, the used additives and /or functionalization processes and heterostructures and deposited onto SiO2/Si and/or alumina MEMS heater platforms. These platforms will be configured in innovative ways to obtain multiple signals from one and the same sensitive layer. Signals recovered will include resistive, field-effect, ion emission and catalytic/thermal conductivity response of the NW materials. Low power operation and additional enhancements in selectivity will be obtained through pulsed-temperature operation and combined self-heated operation mode using dynamic and steady state responses and modulated optical excitation. Furthermore, the increased stability of NW-based sensing materials will positively affect the reliability of the developed sensors. In order to meet application demands, S3 will further explore novel concepts of sampling, filtering and preconcentration of target substances based on nanostructured filter and enrichment materials. The development and the modelling of this new generation of nanostructured gas-sensing and ion emitting materials will be supported by a wide range of morphological and physico-chemical characterisation techniques. The cooperation between EU Union and Russian groups will be improved and strengthened by short and long term exchanges of researchers, the organization of common workshops and tutorials and the establishment of joint doctoral degrees","Surface ionization and novel concepts in nano-MOX gas sensors with increased Selectivity, Sensitivity and Stability for detection of low concentrations of toxic and explosive agents.",FP7,08 July 2014,09 January 2009,1548529.0 S^3NANO,University of Sheffield,information and communications technology,"This network brings together an exceptionally strong group of world leading experts in nano-science and technology in order to achieve breakthroughs in understanding and successful utilisation of nanoscale systems in future devices. The focus of the consortium is on few spin nano-systems in solid-state materials including III-V semiconductors and Carbon-based structures: carbon nano-tubes, graphene and diamonds. Such wide material base emphasizes the truly intersectoral character of this collaboration opening opportunities for crossing the boundaries between several areas of solid-state physics and technology. In order to ensure the highest impact of this collaboration in the emerging supra-disciplinary field of physics and applications of spin nano-systems, we bring together the expertise of the world top class research institutions and industry from 4 European countries. The network will deliver top international level multidisciplinary training to 11 early stage researchers and 5 experienced researchers, offering them, in particular, an extended program of multinational exchanges and secondments. The research and development under this network will undertake a broad scope of tasks important for implementation of spin nano-systems in future devices, such as non-volatile ultra-compact memories, nano-magnetometers, spin qubits for quantum information, and high-efficiency single photon sources. The objectives of the network include: (1) Realization and optical control of coherent single spins in nanostructures; (2) Spin-orbit interaction and spin-orbit qubits in nanostructures; (3) Advanced techniques for manipulation of nuclear spins on the nanoscale; (4) Generation of long-distance entanglement between single spins.",Few Spin Solid-State Nano-systems,FP7,12 July 2017,01 January 2012,4000024.0 SA-NANO,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"Shape controlled nanocrystals increase the functionality of nanoparticles significantly by modifying optical, electrical and chemical properties compared to those of spherical nanocrystals. This can be used advantageously in diverse applications in optics, electronics, bio-medicine, catalysis, but only if viable self-assembly schemes using bottom-up approaches can be realized for these systems. To this end, the project Self Assembly of Shape Controlled Nanocrystals (SA-NANO) will bring breakthrough innovations in the control and understanding of the self-assembly of rod and tetrapod shaped nanocrystals. Rods and tetrapods will be developed so as to posses a functional part and a recognition element for the purposes of self assembly in analogy to biological systems. As one main example, gold tips will be selectively grown on the edges of rods and tetrapods to serve as the recognition elements. These anchor points will be used in the self-assembly of these objects in solution to create rod chains and tetrapod-rod assemblies. Alignment and positioning of these objects onto pre-patterned surfaces, also prepared using self assembly, will be developed. External biases including electric and magnetic fields, as well as microfluidics, will be used to achieve rod alignment and assembly. Theoretical modeling on self-assembly and computation of electronic and optical properties to support the experiments will be also performed. Assemblies of shape-controlled nanocrystals will reveal new collective phenomena that will be studied by diverse techniques including optical spectroscopy, magnetic studies, and scanning probe methods. SA-NANO will advance the self assembly of shape-controlled nanocrystals to the extent that the methods, concepts and understanding of the process will be available for broad implementation in device fabrication based on nanocrystal building blocks, with clear impact for the future of nanotechnology in Europe.",Self Assembly of Shape Controlled Colloidal Nanocrystals,FP6,31 May 2008,01 February 2005,2138864.4 SABIO,Polytechnic University of Valencia * Universitat Politècnica de València,health,"SABIO is a multidisciplinary project involving the emerging fields of micro-nano technology, photonics, fluidics and bio-chemistry, targeting to contribute to the development of intelligent diagnosis for the healthcare of the future. SABIO will address this objective through the demonstration of a compact polymer-based and silicon-based CMOS-compatible micro-nano system. It integrates optical biosensors for label-free biomolecular recognition based on a novel photonic structure named slot-waveguide with immobilised biomolecular receptors on its surface. This structure offers the possibility of confinement and guidance of light in a nanometer-size void channel enhancing the interaction between an optical probe and biomolecular complexes (antibody-antigen). A slot-waveguide interferometric biosensor is predicted to exhibit a surface concentration detection-limit lower than 1 pg/mm2. that is the state-of-the-art in label-free integrated optical biosensors, with additional advantages such as the possibility of multiplexed assay, which, together with reduced reaction volumes, leads to the ability to perform rapid multianalyte sensing tests, offering further advantageous possibility of quantitatively assaying several parameters simultaneously (e.g. several cancer-associated antigens in one sample or several diseases antigens). Consequently, statistical analysis of these results can potentially increase the reliability of a diagnostic over single-parameter assays. In addition, SABIO has the potential to be fast and easy to use, making routine screening of diseases more cost-effective. The ultimate targeted by SABIO is demonstrating the fast diagnostics `outside¿ of laboratory settings (eg. at `point of care¿, in such as General Practitioner¿s surgery, in the field or in urgent situations). A final demonstrator consisting of a packaged biochip will be used on clinical samples in order to detect important diseases such as hepatitis B, CMV and liver cancer.",Ultrahigh sensitivity Slot-wAveguide BIOsensor on a highly integrated chip for simultaneous diagnosis of multiple diseases,FP6,31 December 2008,31 December 2005,2200000.0 SADEL,Innovhub - Stazioni Sperimentali per l'industria,health,"The SME-based SADEL consortium intends to develop the first generation of oral bio-therapeutics tackling disease targets in the digestive tract, by making optimal use of the Nanofitin (Nf) protein scaffold. Nf based drugs will progress through routes not travelled by antibodies while interacting with targets not modulated by chemical compounds. Existing Nf hits against validated targets will progress to the preparation of Phase I Clinical trials in Ulcerative Colitis (UC). To achieve this, SADEL assembles a virtual biopharmaceutical company with SMEs (70%), academics, clinicians and pharma industry with all cutting-edge skills: production (including GMP), analytics, formulation, preclinical and clinical development, up to licensing. Nfs are small (optimal tissue penetration), exhibit strong resistance to pH and human intestinal fluids (long half-life in digestive track) and their high affinity implies low effective concentration. They also demonstrate strong potential for optimizing pharmacological properties, including reducing immunogenicity. The Nf based drugs will be administered orally, reducing the systemic exposure and avoiding the safety issues reported with systemic administration of antibodies. This requires large quantities of proteins for frequent administration. Nfs are produced in bacterial systems for which GMP-compliant processes are broadly adopted in the industry, with a low cost of goods. The resulting proteins will be formulated for optimal release at the sites of action. The project is designed to address unmet technical challenges while avoiding external risks beyond those related to the scaffold behaviour itself. All additional elements are chosen for documented validation, from targets to evaluation protocols. Achieving SADEL aims will solve unmet patient needs by providing affordable, safe, efficient products in a format raising comfort and compliance to treatment. It will also assess the therapeutic potential of the Nanofitin platform.",Scaffolds for alternative delivery,FP7,31 December 2016,01 January 2012,4951792.0 SAE_SNSP_UVA,University of Vienna * Universität Wien,health,"Soils contain the largest pool of carbon on Earth. Cellulose is a major constituent of this carbon since it is a key component of plant structural carbon. Members of the bacteria and fungi are essential for degrading cellulose and thus are essential for cycling carbon. However, the majority of our knowledge on cellulose degradation has been restricted to organisms that we can grow in the laboratory. The reliance on these growth-based methods to understand soil function can be misleading. My previous molecular-based studies, DNA-stable isotope probing (SIP), identified active cellulolytic bacteria and fungi in a collection of different soils, some of which were previously known to degrade cellulose along with other, putatively novel groups. However these studies did neither delaminate the specific bacterial and fungal contributions to cellulose degradation in these soils nor did they reveal systematic differences in the time course of cellulose degradation among these active groups. Furthermore, the putative novel cellulolytic fungal and bacterial groups warrant follow-up work to ascertain if these groups were responsible for the primary breakdown of cellulose and were not only detected as the result of cross feeding. In order to overcome these issues and expand on my previous SIP work, I propose to use SIP with 13C-cellulose in combination with Halogen In Situ Hybridization-Secondary Secondary Ion Mass Spectrometry (HISH-SIMS) to determine and to quantify the in situ contributions of active cellulolytic microorganisms in the soil environment in a previously unachievable manner. The expected scientific outcome include: (1) system-level understanding of the metabolic networks of cellulose degradation; (2) basic understanding of the degree and efficiency cellulose is degraded by microorganisms; (3) improved understanding of primary and secondary responding populations to cellulose; and (4) better characterization of the seemingly unknown groups of cellulose degraders.",NanoSIMS Enabled Approach to Understand Bacterial and Fungal Cellulose Degraders in Soils,FP7,31 March 2014,01 April 2012,180191.0 SAFE PIPES,VCE Holding GmbH,manufacturing,"Our industrial infrastructure is aging affecting society, economy and industry. Risk assessment and lifetime management gains importance with the progressive aging of industrial installations. The overall objective is to develop a complete integrated monitoring system that allows to rate industrial piping systems over their whole service life and to increase the general safety. The goal is to reduce investment cost for maintenance, inspection and loss of production as well as to limit accidents, hazardous to mankind and environment. This proposal addresses important industrial lifecycle issues of the nuclear industry and the sector of chemical plants. Current, visual inspection based, methodologies shall be replaced by online sensor and decision support systems. No limit for the assessment throughout the lifecycle shall remain. The conceptual objective is to demonstrate the opportunities for the advanced technology to deliver a radical new approach to the lifecycle control and maintenance of structures. This will be achieved by showcasing the optimisation of piping systems in industrial installations that is enabled through a new rating paradigm for risk assessment, management, maintenance and retrofit. A complete integrated monitoring system will allow to rate industrial piping systems over the whole service life and to increase the general safety. One of the main obstacles in pipe monitoring is the existence of non accessible parts of the system, for example if pipes are passing river basins, running subsurface or inside concrete structures. The objective is to use novel technologies like acoustic emission, guided mechanical wave propagation, tomographic imaging and flexible piezoelectric fibre sensors to overcome that obstacle. The fibres are produced in a nanoscale sol-gel process. The goal is to enable the monitoring of non-accessible parts of the piping system to identify critical faults and to localise the damage in the system automatically.",Safety Assessment and Lifetime Management of Industrial Piping Systems,FP6,31 August 2008,01 September 2005,1500000.0 SAFEDNA,Braunschweig University of Technology * Technische Universität Braunschweig,health,"In this project we will prepare the commercialization of a new patent-protected signal amplification scheme for simpler and faster molecular diagnostics of pathogens such as Chlamydia trachomatis (CT). CT causes more cases of sexually transmitted diseases (STD) than any other bacterial pathogen, making CT infections an enormous public health problem throughout the world. Nowadays, diagnosis is commonly carried out using nucleic acid detection by fluorescence readout after polymerase chain reaction (PCR). However, DNA amplification requires technical equipment too sophisticated for application in developing countries or in standard labs in a medical practice. For cheaper, faster and even point-of-care diagnostics, a simpler amplification mechanism for a testing method capable of detecting DNA in small concentration is required. Here, we suggest applying a new and universal signal amplifying approach that does not require any extra steps after target recognition. It relies on direct enhancement of the fluorescence readout signal using a self-assembled nanolens that was invented within the framework of the ERC starting grant SiMBA. The self-assembled nanolens is capable of enhancing the intensity of fluorescent dyes in a nanosized hotspot by more than two orders of magnitude. Further enhancement is conceivable. Braunschweig University of Technology has filed a broad patent application securing intellectual property rights for the project. We will test this direct fluorescence enhancement scheme for the fast and sensitive detection of CT. Therefore, the self-assembled nanolens will be adapted for the detection of a CT target DNA by equipping the nanosized hotspot of the nanolens with probe DNA sequences. The target is then visualized by sandwich hybridization of a second specific, fluorescently labeled DNA strand. We envision an improved test for CT detection: it should be faster, simpler and price-competitive.",safeDNA - self-assembled fluorescence enhancers for the Detection of Nucleic Acids,FP7,31 January 2015,01 February 2014,149491.0 SAFEHOSE,Sims Engineering Systems Ltd.,transport,"This project proposes to generate new scientific understanding of the processing of thermoplastics using microwave energy for targeted, controlled melting, drilling by ablation and controlled hardening. It also proposes to generate new understanding of resonant vibration attenuation in fluid transmission systems, barrier properties of thermoplastics (eg using nano-fillers), recycling of multi-material assemblies and selective stiffening of fibrous reinforcement by infiltration of thermoplastic melt. This new knowledge will initially be used to develop a radically innovative production process for fluid transmission systems to produce single-piece, multi-channel, selectively stiffened, internally-drilled hoses with inherent and specific vibration attenuation characteristics, enhancing the performance and functionality of hydraulic systems. Integrated with this will be smart end fittings, incorporating an innovative low-cost self-sealing device with built in system sensing and diagnostics, and the entire assembly will be designed with inherent recyclability and a fully developed recycling strategy. This represents a major advance on current manufacturing methods involving assembly of metallic and rubber sections of tube, enabling lighter, cheaper and more reliable products. The production process will be based on parametric methods to reduce the need for tooling, thus increasing flexibility and reducing lead times. The process developed will be disseminated beyond the automotive case study to other fluid transmission applications in industry, aerospace, white goods, agriculture and so on.Furthermore, the technology will be adapted and disseminated throughout Europe to SMEs in other applications where the core technology is applicable, thus encouraging the shift of traditional, resource-based SMEs towards an RTD-focussed, knowledge-based economy.This will then launch other development programmes to deploy the core scientific understanding in many varied applications.","A Radically Innovatie New Production Process for Single-Piece, Recyclable Fluid Transmission Systems with Self-Diagnostic Capability to Fluid Loss Potential",FP6,31 August 2008,01 September 2004,2749193.0 SAFEPROTEX,Materials Industrial Research & Technology Center (MIRTEC),health,"The idea that constitutes the basis of the proposed project is to address the main issues that currently limit the wide acceptance of protective garments, i.e. protection against multiple hazards, extension of the life-cycle of protective garments, physiological comfort and mechanical parameters. Overall, the proposed research activities aim at addressing the complex risky conditions met in various types of emergency operations, e.g. during accidents involving the threat of chemicals, extreme weather conditions (flood, wind storms, hail etc), small scale fires, or combinations of those. The manufacture of three prototypes is provisioned. In order to achieve these objectives, progress beyond the state of the art is required in a variety of fields. In fact, the project is highly multidisciplinary and requires developments in diverse areas such as polymers science and technology, polymers processing, new additive masterbatches development and fiber spinning, nanotechnology, plasma technology, sol-gel technology, smart thermoregulating materials, microencapsulation, ergonomic garment design, etc. The major innovations regard, but are not limited to, the development and application of specific functionalizing materials, capable of providing multiple protective functions. More specifically, the main materials to be examined include layered silicates, carbon nanotubes, alkoxysilane primers, chromic materials, antimicrobial microspheres, etc.",High-protective clothing for complex emergency operations,FP7,30 September 2013,01 April 2010,3099368.0 SAFER,Rovira i Virgili University * Universitat Rovira i Virgili,health,"The establishment of non-invasive markers for prenatal diagnosis and is a very important research goal. Current invasive procedures have (1) a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psychological distress. The overall objective of this project is to exploit breakthroughs at the confluences of bio-, micro- and nano- technologies to create a low-cost non-invasive intelligent diagnosis system using a nanotechnology-based device for the isolation, enrichment and detection of foetal cells from maternal blood so as to facilitate non-invasive pre-natal diagnosis. Advances in molecular biology and biosensor technology and the integration of nanostructured functional components in macro and microsystems will facilitate the separation of foetal cells from maternal cells on the basis of cell size, deformability, surface chemistry, novel markers, and charge. Addressing health care requirements of the future of an individualised theranostic approach, the specific application that will be demonstrated will be the isolation of foetal cells with the platform technology being applicable to the isolation of early cancer cells as well as stem cells in peripheral blood. The proposed technology is highly ambitious in nature and meets the ADVENTURE requirements of being a visionary, far-reaching, multidisciplinary project, that contributes substantially to the state-of-the-art with novel technologies of immense impact, with potential applications in non-invasive prenatal diagnostics, cancer diagnostics and theranostics and isolation of stem cells, not to mention the second tier of simpler devices exploiting some of the proposed modules for POC diagnostics, environmental and food quality control monitoring. The proposed technology does not fall directly within the domains of research of the FP6 thematic priorities.",Isolation of foetal cells from maternal blood: A nanomolecular approach,FP6,14 February 2008,15 February 2005,2000000.0 SAFETECHNOPACK,Scientific and Technological Research Council of Turkey * Türkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK),health,"TUBITAK MRC Food Institute (FI) aims to become one of the leading food science and technology institutes in the EU. In order to achieve its aim FI analysed its weak points, and food packaging technologies are one of them. The main objective of this project is to improve the scientific and technological (S&T) capacity of FI in food packaging technologies. It is believed that FI will increase its participation in FP7 projects by the achievement of this proposal. Specifically, it is aspired to improve the research capacity in chemical contamination from the food contact materials, and developing new food packaging materials using nanotechnology and active antimicrobial packaging technologies. SAFETechnoPACK addresses completely the general objectives of the FP7 REGPOT-2007-1. In order to accomplish the main objective, FI has established the following specific objectives corresponding to the below work packages: •Upgrading S&T equipment infrastructure: involves the upgrading of the S&T equipment infrastructure of FI on packaging technologies, •Recruitment of researchers: involves the recruitment of two researchers in the field of chemistry and polymer science on new packaging technologies, •Networking and co-operative activities: involves participation in international conferences, technical visits to centres in Member States (MSs), organization of brokerage events, international conference and Advisory board meetings, •Improvement S&T experience and knowledge of researchers: involves the improvement of scientific and technological experience of researchers by long term and short term trainings in MSs, and exchange of know-how and experience by inviting expert scientists from MSs. •Information and dissemination activities: involves the setting up project web page, preparation of leaflets, organisation of info days and participation",Improving the Scientific and Technological Research Capacity of Food Institute on Safety and Technology of Food Packaging,FP7,31 January 2012,01 February 2008,950000.0 SAHNMAT,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"The construction of nanostructured objects of well-defined size is of outmost importance for nanotechnology to surmount claims for potential applications and exploit improved chemical, physical or biological properties of a functional nanofeatured material. Biomedical imaging is one particular field of interest for water-compatible chemical self-assembly of nanosized objects. The outlined project aims to develop a methodology for the preparation of nanostructured objects in aqueous media with the emphasis lying on the precise control over the size, shape and degree of functionalisation of the features. The goal is to build upon supramolecular helical scaffolds for the development of self-assembled functional structures in the nanoscopic range, which are to be used in magnetic resonance imaging (MRI) applications. MRI has made a significant impact to the area of diagnostic medicine, predominantly due to advances in the development of contrast agents (e.g. paramagnetic Gd(III)-complexes). We believe that a supramolecular approach based on self-assembled Gd(III) chelating molecular units can combine the benefits from both low and high molecular weight derivatives: high contrast agent efficiency or contrast enhancement on one hand, and an improved control over the pharmacokinetics on the other hand, because of the non-covalent dynamic nature that holds the objects together. Furthermore, challenges in the field of MRI contrast agents will be met by the development of multivalent target-specific structures. Advantages include the accumulation of MRI signals in a region of interest, and the combination of 1H MRI contrast enhancement with a second imaging label. 19F MRI is a highly promising probe because of the high sensitivity of the 19F nuclide and the absence of any background interference in living systems.",Self-assembly of Helical Functional Nanomaterials,FP7,28 February 2011,01 March 2009,160028.0 SALINAME,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),manufacturing,"The goal of this project is to study and control the self-assembly of superparamagnetic iron oxide nanoparticles (NPs) stabilized by a shell of responsive polymers at liquid-liquid interfaces in order to crosslink them into ultra-thin, mechanically stable, responsive membranes. This novel “smart†material will have unique properties suitable for applications in miniaturized lab-on-chip and other microfluidics devices. The interdisciplinary nature of the project contributes to its scientific novelty and impact, and constitutes an extraordinary training experience for the applicant. In the first part of the project, the applicant will develop a novel combination of experimental techniques to characterize the fundamental aspects of core-shell NP adsorption at liquid-liquid interfaces. By means of advanced confocal microscopy and particle tracking, complemented by pendant-drop tensiometry, this project will yield an exhaustive characterization, both from a microscopic and macroscopic point of view, of such system, so far practically unexplored. The obtained understanding - of high scientific relevance in its own right - will be used to optimize the design and fabrication of crosslinked responsive NP monolayer membranes. Using superparamagnetic NPs stabilized by a shell of crosslinkable thermoresponsive polymers, the applicant will produce ultra-thin robust assemblies which can respond reversibly to external stimuli. Temperature changes and consequent responses can be imparted to the system locally by exploiting the magnetic functionality of the NP constituents (heat transfer in an AC magnetic field). Moreover the crosslinked membranes can be actuated in DC magnetic fields as envisaged for applications. The responsive properties of the resulting materials, which have no current equivalent, will be investigated by means of optical and atomic force microscopy (structural properties) and microrheology and colloid-AFM force spectroscopy (mechanical properties).",Self-assembly of magnetic core-shell nanoparticles at liquid-liquid interfaces for the fabrication of ultra-thin responsive membranes,FP7,06 June 2014,07 January 2010,173065.2 SALMOVIR,Helmholtz Centre for Infection Research * Helmholtz-Zentrum für Infektionsforschung,health,"Salmonella are motile, gram-negative, pathogens that infect eukaryotic cells. Outbreaks of salmonellosis are a great economic and health problem worldwide. Many bacteria, like Salmonella, swim through liquid environments by rotating a helical organelle, the flagellum. This sophisticated nanomachine is functionally and structurally related to virulence-associated type-III secretion systems (T3SS) of pathogenic bacteria. The ability to move is of crucial importance for Salmonella virulence and infection of eukaryotic cells. Although the importance of bacterial motility and T3S in virulence of Salmonella is established, a detailed understanding of the expression and molecular interplay between the flagellar and virulence systems during infection is missing. The aim of this research program is to study the mechanisms of bacterial motility during bacteria-host interactions and the molecular function of T3SS using an unique combination of sophisticated bacterial genetics, microscopy, biochemistry and infection biology techniques. Both flagellar motility and the process of T3S are essential for virulence and represent attractive targets for novel anti-microbial agents. Therefore, I will analyze the general importance of flagella and bacterial motility during the Salmonella infection process (Aim 1). In complementary projects, I will focus on the molecular mechanisms of bacterial T3SS like the mechanism of substrate translocation (Aim 2), and screen for compounds that inhibit T3SS (Aim 3). The proposed research program will provide novel and fundamental insights into our understanding of the molecular details of Salmonella virulence. Thereby, the initial events required for the commitment of the bacteria to invasive diseases could become clear. Importantly, this knowledge could be used to design specific inhibitors of bacterial T3SS, which might have the potential for new anti-bacterial agents that are urgently needed at a time when antibiotic resistance is increasing.",Molecular mechanisms of bacterial motility and type-III secretion in virulence of Salmonella,FP7,31 March 2017,01 April 2013,100000.0 SAMCYLINS,University of Bristol,manufacturing,"In this proposal a plan is outlined which aims to develop the solution self-assembly of metal-containing block copolymers. The program will develop novel cylindrical nanostructures and explore their applications as nanosize wire-like architectures. The materials will combine the novel functional properties imparted by the presence of metal atoms to the core of the nanostructure. The interdisciplinary project will involve synthetic polymer chemistry, detailed characterization and studies of physical properties. Applications of the materials in nanoscience, for example in devices and as etch resists, will then be explored. Applications in the nanomaterials area will be studied not only in the Manners laboratory but also by i) making use of membership in the UK's Interdisciplinary Research Centre in Nanotechnology ii) the facilities in the new Bristol Nanoscience and Quantum Information Building to be completed in 2006 andiii) developing collaborative interactions within the EU.A key aim will also be to develop interactions with world leading scientists elsewhere in Europe interested in the applications block copolymers in nanoscience. The aim will be to create interactions which will facilitate information and expertise exchange and which will ultimately set up possibilities for new collaborative research projects which utilize the expertise of the applicant (Manners) and which open up new vistas with the EU at the cutting edge of this globally competitive area. This will be accomplished through travel of the applicant to these groups and institutions to visit, interact, and to give lectures.'","Self-Assembled Metallized Cylindrical Nanostructures: Creation, Manipulation and Function",FP6,31 December 2007,01 January 2006,80000.0 SAMSFERE,University of Valencia * Universitat de València,information and communications technology,"Organic materials offer unique properties like: i) processablility and plastic technology compatibility, ii) monodispersity and tunability and iii) long time spin coherence that make them appealing for spintronics devices and hence, a great number of proposals exits about its use in spintronics applications. Nevertheless, organic spintronics is in its infancy and so far only a small number of different organic materials have been used in spintronic research to realize an even smaller number of this proposals. First reports on the integration of organic materials into spintronic devices date back to 2002. Self-assembled monolayers with their special characteristics are an invaluable tool set for the developing and understanding of spin transport. As tunnel barriers SAMs i) Can be easily engineered: Are modular and their parts can be exchanged while keeping the others unchanged, ii) Are intrinsically nanometre thick: Film thickness will be determined by molecule size and SAM structure, iii) Have defined structures: SAM formation is a self-assembly process, structure is preprogramed and iv) Are promising to candidates to work at high-bias. SAMSFERE aims to expand the current know-how in the field of organic spintronics and lay the base of a solid understanding of the spin-transport through interfaces by the growing of a completely new set of SAMs over FM electrodes that will be employed in the development of devices based on magnetoresistive effects(organic magnetic tunnel juntions) and beyond (spin organic light-emmiting diodes).",Self-Assembled Monolayers over Ferromagnetic Electrodes for Organic Spintronics,FP7,11 June 2017,12 January 2012,75000.0 SAMUFLU,Novartis Vaccines & Diagnostics Srl,health,"Influenza (Flu) virus infections lead to thousands of deaths annually worldwide and billions of dollars of economic burden. Vaccination is the primary strategy for Flu prevention; however, effective protection requires a perfect match with the seasonal circulating strains. Seasonal vaccines target the hemagglutinin (HA) and neuraminidase (NA) proteins of the two predominant A and one B circulating strains, and induce high neutralizing antibody titers. Emerging Flu viruses escape host immunity by modifying HA glycosylation and masking the immunodominant epitopes of previous years' strains. In consequence, yearly seasonal Flu vaccines have to be developed. Therefore, there is a need for a universal Flu vaccine that would protect against most variants. Patterns of HA glycosylation show that there are only 5 -6 alterations in a century of evolution, reflecting the limited possibilities for the virus to escape host immunity while retaining its infectivity. Therefore, by developing a vaccine that includes most relevant past seasonal (H1, H3, and B) and pandemic (H5, H7) strains, it might be feasible to develop a universal Flu vaccine. The project will combine HA selection with the novel self-amplifying mRNA (SAM®) vaccine technology, which consists of a synthetic RNA delivered by lipid nanoparticles, and already proved immunogenic in mice with Flu H1 and H7. We will design five SAM(HA) vectors encoding combinations of four HA, prioritized to cover up to 20 relevant strains, and characterize their immunogenicity in mice by measuring hemagglutination-inhibition and virus neutralization titers. In-depth characterization of germinal center B cells and follicular helper T cells will be performed by mass cytometry (CyTOF). Finally, HA-specific CD4 and CD8 T-cell cytokine and cytotoxic responses will be determined by mass cytometry for correlates of protection. At the end of this proposal, the development of a universal Flu vaccine should be achieved.",Self-amplifying RNA technology applied to the development of a universal influenza vaccine,FP7,31 March 2016,01 April 2014,187414.0 SAMUL-NANO-HEP,University of York,health,"This proposal targets the development of self-assembling nanoscale systems to bind heparin. Heparin is widely used as an anti-coagulant during major surgery, but once surgery is complete, it is necessary to remove the heparin and allow clotting to begin. The current therapy is protamine, a protein extracted from shellfish which acts as a powerful heparin binder, but unfortunately, causes allergic response and other problems in significant numbers of patients (ca. 10%). We are therefore targeting the development of novel synthetic nanoscale protamine replacements which may avoid some of these difficulties. Our unique strategy is to develop small molecules which self-assemble into nanoscale heparin binders. This has the advantage of being highly tunable and uses low molecular-weight (drug-like) building blocks -allowing structure-activity relationship understanding of the binding event to emerge. The self-assembled structures will be optimised in terms of their charge density, morphology, display of functional groups and ability to degrade, to maximise heparin binding and surgical potential. This project will provide fundamental insight into the requirements of an effective heparin binder. Our optimised systems will be tested in clotting and toxicity assays, and may have longer-term applications in a medical setting.",Self-Assembling Multivalent Biodegradable Ligands for Nanoscale Heparin Binding,FP7,30 September 2016,01 October 2014,221606.0 SANAD,Global Nanotechnologies SA,information and communications technology,"The efficiency of modern transportation is severely compromised by the prevalence of turbulent drag and icing. The high level of turbulent skin-friction occurring, e.g., on the surface of an aircraft, is responsible for excess fuel consumption and increased carbon emissions. The environmental, political, and economic pressure to improve fuel efficiency and reduce carbon emissions associated with transportation means that reducing turbulent skin-friction drag is a pressing engineering problem.",Synthesis of Advanced top Nano-coatings with improved Aerodynamic and De-icing behavior,FP7,12 July 2018,01 January 2013,0.0 SANDIE,Leipzig University * Universität Leipzig,photonics,"The Network of Excellence is dedicated to the formation of an integrated and cohesive approach to research and knowledge in the field of Self-Assembled semiconductor Nanostructures (SAN). These nanostructures can then be cemented in position by the deposition of further layers of the substrate material. By varying the semiconductor materials involved, the growth conditions, and by vertically stacking layers of nanostructures, a rich variety of novel materials can be produced for the study of the fundamental properties of strongly confined systems, and for the development of advanced electronic and optoelectronic devices. The resources and the approach of the Network reach from the study of fundamental phenomena to their exploitation for the design of novel materials and structures for use in advanced electronic, photonic and optoelectronic devices. In particular the activities on devices are tightly integrated with European industrial partners of the Network. The Network will spread excellence outside the Network, in particular to the new member states via gateway institutes in the new member states. A measurable integration of the human resources, equipment and methods in the European research area will be achieved by the Network with a program of joint activities. The integration pertains to people, facilities, research, training and education and exploitation. In particular the Network funds will be used for supporting the exchange of personnel, joint PhD programs, increased availability, access and throughput of experimental facilities, the design, preparation and execution of joint research projects, education and training programs including workshops, schools and technical training courses, outreach to the scientific community and the general public and the exploitation of scientific and technological results together with the industrial partners.",Self-Assembled semiconductor Nanostructures for new Devices in photonics and Electronics,FP6,30 June 2008,01 July 2004,9200000.0 SANES,University of Szeged * Szegedi Tudományegyetem,information and communications technology,"We propose to develop a new integrated self-adjusting nanoelectronic sensor (SANES) based on functionalized carbon nanotubes as active elements. The multifunctional sensor micromodule will consist of a matrix of differently functionalized CNTs which are integrated into an electronics package (electronics and software also developed in the framework of the project) capable of: - recording and analyzing the signal of a very small number (target: only one single nanotube) of sensing elements - monitoring several factors (e.g. temperature, pressure, gas atmosphere etc.) simultaneously - actively change the local chemical environment of the sensor component CNTs (self-adjusting behavior) The primary objective of this proposal is to design, construct and analyse such novel sensor modules integrated in an intelligent micromodule. We intend to build the working prototype of the modul and perform its complete evaluation regarding sensitivity, selectivity, stability and reproducibility. We will conclude the project by performing a feasibility study on the possibilities of the production scale-up for the developed sensor module.",INTEGRATED SELF-ADJUSTING NANO-ELECTRONIC SENSORS,FP6,31 March 2009,01 April 2006,1201500.0 SANOWORK,National Research Council * Consiglio Nazionale delle Ricerche (CNR),environment,The main goal of Sanowork project is to identify a safe occupational exposure scenario by exposure,Safe Nano Worker Exposure Scenarios,FP7,02 April 2017,03 January 2012,0.0 SANS,London School of Economics and Political Science,energy,"Widespread uptake of inorganic semiconductor solar cells has been limited, with current solar cell arrays only producing arround 10 GW of the 15 TW (~0.06%) global energy demand, despite the terrestrial solar resource being 120,000 TW. The industry is growing at a cumulative rate of over 40% per annum, even with effects of the financial crisis. However, to contribute to global power this century, growth of around 100% pa is required. The challenge facing the photovoltaic industry is cost effectiveness through much lower embodied energy. Plastic electronics and solution-processable inorganic semiconductors can revolutionise this industry due to their relatively easy and low cost processability (low embodied energy). The efficiency of solar cells fabricated from these 'cheap' materials, is approaching competitive values, with comparison tests showing better performance for sensitizer activated solar cells with reference to amorphous silicon and CIS in Northern European conditions. A 50% increase of the output will make these new solar cells commercially dominant in all markets since they are superior in capturing photons in non-ideal conditions (angled sun, cloud, haze) having a stable maximum power point over the full range of light intensity. To enable this jump in performance in a timely manner, a paradigm shift is required. The revolutionary approach to these solar cells we are undertaking in the SANS project is exactly that and matches the desires of the IEA for mitigation of climate change. Our objectives are to create: highly efficient panchromatic sensitizers, ideally structured semiconducting metal oxide materials and composites; optimized non-volatile and quasi solid-state electrolyte compositions and solid-state organic hole-transporters; achieve full comprehension of the physical processes occurring during solar cell operation; and realization of a 40,000 hrs out door lifetime, being the springboard for commercialization.",Sensitizer Activated Nanostructured Solar Cells,FP7,31 December 2013,01 January 2011,3991060.0 SANTS,University of Leeds,health,"Molecular events occuring at the nanoscale impact on the macroscopic level in many different areas and rules for nanoscale manufacture are important to understand. The SANTS project will improve knowledge in nanoscale manufacturing and create new molecular materials for both biosensors and biocatalysed synthetic chemistry, using techniques inspired by natural biosilication processes. The project is based on proven observations that natural silaffin proteins, synthetic peptides based upon them and synthetic peptide mimics are able to efficiently catalyse biosilication. One key project innovation is to engineer and covalently tether these peptides and peptide mimics to gold or other materials to create self assembling nanostructured biocatalytic and biosensor surfaces. The project targets NMP-2004-3.4.1.2-1 'Using nature as a model for new nanotechnology based processes'; NMP-2004-3.4.1.3-1 '3D nano-structures based on elements other than carbon' and NMP-2004-3.4.2.1-1 'Interfacial phenomena in materials'. The project goes beyond the state of the art in many areas involving synthesis of spontaneous self-assembling precursors to immobilise enzymes, including multifunctional enzyme cascades, giving significant strategic impact for the EU i n nanoscale manufacturing and addressing community societal objectives in two distinct ways. 1) the production of new sensors for enviromental, healthcare and process industry targets, e.g. OP pestcides/ stroke markers: and 2) new stable and efficient biocatalysts that will impact the EU's sustainable chemical policy of moving towards greener chemical production. The project is structured into 8 workpackages including peptide and peptide mimic production that initiate nanostructured silicate formation, enzyme immobilisation for biocatalyst and nanostructured sensors, microfluidics and characterisation of the interfacial interactions and 3D structures produced and involves a world class team of 8 partners.'",Synthesis and nanotechnologial application of tethered silicates,FP6,31 January 2010,01 August 2006,2399896.0 SAPHIR,Compagnie Industrielle des Lasers (CILAS) SA,transport,"Industrial needs in terms of multifunctionnal components are increasing. Several sectors are concerned, ranging from mature high volume markets like automotive applications, high added value parts like space & aeronautic components or even emerging activities like new technologies for energy. Also are concerned domains with a planetary impact like environment and new products and functions for health and safety of people. Nanotechnologies could play a key role in promoting innovation in design and realisation of multifunctional products for the future, either by improving usual products or creating new functions and new products. Nevertheless, this huge evolution of the industry of materials could only happen if the main technological and economic challenges are solved with reference to the societal acceptance. Those concern the mastering, over the whole life cycle of the products, of the potential risks, by an integration of the elaboration channels, while taking into account recycling. The general objective of the project is the safe, integrated and controlled production of high-tech multifunctional nano-structured products including their recycling, and ensuring competitiveness. It means that i) all along the production sequence, no nanoparticle release will be encountered. This includes synthesis, recovery (direct liquid recovery), conditioning (advanced granulation), processing and handling; ii) the whole production sequence will consist in linking in a safe way existing or emerging elementary processes (direct plasma spraying, laser 3D direct manufacturing, and powder consolidation techniques); iii) the production sequence will be controlled by innovative systems covering process efficiency, product reliability, global safety production, & traceability; iv) recyclability issues will be addressed and v) generic tools will be developed.",CONTROLLED PRODUCTION OF HIGH TECH MULTIFUNCTIONAL PRODUCTS AND THEIR RECYCLING,FP6,30 November 2010,01 October 2006,8097100.0 SAPNOB,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),information and communications technology,"Nanotechnology involves the creation and utilization of materials and devices on the nanometer scale. In our days, biosensors are among the most promising nanotechnological achievements. They have emerged as reliable analytical tools in biomedicine, biology and environmental control. Recent developments of fabrication processes in the nanometer range by template based synthesis and deposition techniques have supplied new impetus to the concept of biosensor membranes. Methods for the production of individual parts with such small dimensions are quite readily available, but the controlled and efficient assembly of these parts into structures of higher order still remains a challenge. Besides, the production of a highly effective biosensor membrane requires not only miniaturization of the desired nanostructures into greater hierarchy, but also extreme care in the selection of correct functional groups and their optimum density.Based on the template synthesis technique, two different strategies to prepare well-ordered arrays of poly (gamma-Benzyl-L-Glutamate), PBLG polypeptide nanotubes as basis for optical biosensor applications are proposed here. By combining synthetic chemistry, photolithography for the assembly of nanotubes, and immobilization of biomolecules of special interest, well-ordered biosensor membranes with particular electro-optical properties should be obtained. Special emphasis is placed on the ability of PBLG biosensor membrane to quantify the amount of adsorbed biomolecules through the changes of the refractive index. The challenges and the architectural design strategies of the proposed research study are highlighted in detail. Additional emphasis is put on the characterization of the arrays of polypeptide nanotubes: electro-optical, structural and mechanical properties will be investigated. Finally, the quality of the two proposed techniques will be compared on the basis of the results of the aforementioned characterizations.",Synthesis and Assembly of Polymeric Nanotubes for Optical Biosensing,FP6,31 December 2007,01 January 2006,149722.0 SARISTU,Airbus Operations GmbH,transport,The project proposal concerns the challenges posed by the physical integration of smart intelligent,Smart Intelligent Aircraft Structures,FP7,08 July 2017,09 January 2011,0.0 SAVEME,Tel Aviv University,health,"SaveMe project will address current urgent needs for pancreatic cancer diagnosis and treatment by exploiting partners' expertise and most recent research achievements for the design and development of novel modular nanosystems platform integrating new functionalized nano-core particles and active agents. The modular platform will enable the design of diverse active nanosystems per diagnostic or therapeutic application as defined by their active agent compositions. For diagnostics, superior tracers will be developed for molecular MR/PET and gamma camera imaging, enabling efficient diagnosis and guided surgery respectively. Novel functionalized nano-core systems will be conjugated with semi-confluent active shell layer. Three types of shell layers will be design: (1) novel iron oxide nanoparticles as advanced MRI contrast agents and/or (2) DOTA complexes for MRI (with Gd3+), or PET (with Ga-68), or gamma camera (with Ga-69); (3) Integrating within one tracer both iron oxide nanoparticles and DOTA-Ga-68 complexes for a sequential or simultaneous MR/PET imaging. For therapeutics, active nanosystems will be developed to deliver (1) therapeutic siRNAs or (2) anti-MP-inhibitory-scFVs. These non-classic anti-tumor drugs will be designed based on an extensive tumor degradome analysis for combining blockage of selective matrix MPs, thus preventing basic invasive and metastasis steps, with siRNA based neutralization of secondary molecular effects induced by the specific protease inhibition. Individualized degradome analysis will be developed for potential profiling of anti-MP and siRNAs based therapy per patient. To facilitate the above diagnostics and therapeutic effects, advanced tumor targeting and penetration active agents will be linked to nano-core functionalized groups, including a biocompatible PEG layer linked to tumor selective MMP substrate molecules and highly safe and potent novel somatostatin analogue peptides targeting SSTR overexpression.","A Modular Nanosystems Platform for Advanced Cancer Management: Nano-vehicles; Tumor Targeting and Penetration Agents; Molecular Imaging, Degradome based Therapy",FP7,28 February 2015,01 March 2011,1.05E7 SAVVY,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),health,"The Self-Assembled Virus-like Vectors for Stem Cell Phenotyping (SAVVY) project relies on hierarchical, multi-scale assembly of intrinsically dissimilar nanoparticles to develop novel types of multifunctional Raman probes for analysis and phenotyping of heterogeneous stem cell populations. Our project will address a large unmet need, as stem cells have great potential for a broad range of therapeutic and biotechnological applications. Characterization and sorting of heterogeneous stem cell populations has been intrinsically hampered by (1) lack of specific antibodies, (2) need for fluorescence markers, (3) low concentration of stem cells, (4) low efficiencies/high costs. Our technology will use a fundamentally different approach that (1) does not require antibodies, aptamers, or biomarkers, (2) is fluorescence-label free, and (3) is scalable at acceptable cost. The approach uses intrinsic differences in the composition of membranes of cells to distinguish cell populations. These differences will be detect by SERS and analysed through multicomponent analysis. We have combined the necessary expertise to tackle this challenge: Stellacci has developed rippled nanoparticles that specifically interact with and adhere to cell membranes (analogues to cell penetrating peptides). Lahann has developed bicompartmental Janus polymer particles that have already been surface-modified with rippled particles and integrate specifically in the cell membrane (analogues to viruses). Liz-Marzan has developed highly Raman-active nanoparticles and has demonstrated their selectivity and specificity in SERS experiments. These Raman probes will be loaded into the synthetic viruses to enable membrane fingerprinting. Stevens has developed a Bioinformatics platform for fingerprinting of stem cell populations using cluster analysis algorithms. The effort will be joined by two SMEs, ChipShop and OMT, that will be able to develop the necessary microfluidic and Raman detection hardware.",Self-assembled virus-like vectors for stem cell phenotyping,FP7,31 December 2015,01 January 2013,3782729.0 SAWQUBIT,University of Cambridge,information and communications technology,"The proposal is aimed at the experimental development of a novel solid-state quantum computation scheme and its interface to quantum optics. The computation scheme, put forward at the University of Cambridge, uses the spin of an electron trapped in the dynamic potential associated with a surface acoustic wave (SAW) as a “flying” qubit. The capture of single electrons in moving quantum dots occurs when the SAW passes along a depleted 1D channel. Channels in parallel provide the set of qubits, forming the core of a SAW-based quantum processor. The objective of this proposal is the development of such SAW-driven single-electron quantum devices and the optical readout of the spin of the electron to extend the capabilities of the quantum processor into the optical domain for quantum communication. A lateral n-p junction will be introduced into a GaAs heterostructure, where each electron recombines, leading to single-photon emission. The measurement of the polarization of the emitted photon will determine the spin of the electron, since the conservation of the angular momentum dictates that the photon will have left or right circular polarization depending on the sign of the component of the electron’s spin in the direction of propagation of the photon. Therefore, the flying-qubit processing scheme may permit the distribution of quantum information quickly over large distances across the quantum circuit, to interface with quantum memory registers at fixed localizations or static qubits, and to transfer a qubit from an electron in a quantum dot to a polarized photon. In addition, the fact that the flux directly measures the average spin alleviates the need for single-shot spin or photon measurements and greatly improves the signal-noise ratio. The cutting-edge research of this proposal will permit the fellow to acquire a strong hands-on experience on the most advanced techniques of nanoelectronics, which will have an enormous impact on his career development.",SAW-driven single-electron quantum devices with optical readout of the spin,FP7,12 July 2013,01 January 2010,171867.63 SBL,Technion Israel Institute of Technology,information and communications technology,"One of the main goals of scientific research nowadays is to develop methods to prompt and control natural processes at nanometre and micrometre resolutions for advancing technological capabilities at such length resolutions. Many corresponding examples exist, from which we bring the field of molecular electronics; although advanced remarkably in recent years, this field lacks cheap and efficient integration methods for fabricating nano- and micro-scale complex and inter- and intra-connected artificial structures made of large quantities of electronic building-blocks such as gold nano-particles, carbon nano-tubes, polymeric semiconductor wires, and other molecules of electronic viability 2-5. The PI is proposing to study the physics associated with translating complex electronic signals, comprising MHz to GHz frequencies, to uniquely determined micron and submicron non linear flow patterns, capable of integrating particulate suspensions into structures at related resolutions; flow is invoked through the intermediate step of translating electronic signals to packets of Rayleigh surface acoustic waves (SAWs) atop a piezoelectric SAW device in contact with particle suspensions that undergoes attachment/detachment processes according with the spatial strength and directionality of the flow and attraction/repulsion DLVO forces between the particles themselves. The PI will, foremost, elucidate the physics of SAW induced complex micron and submicron stable and unstable stagnant flow patterns in microchannels, and will further study stability of multiple particle suspensions, crumbed into patterns by flow, using principles of colloid science and the physics of particle interactions. This proposed study thus suggests a new approach for managing and controlling natural processes in nanometre and micrometre resolutions.",Study of high frequency vibration induced steady wetting and of high frequency vibration induced nanoparticle assembly for molecular electronics,FP7,10 July 2019,11 January 2013,100000.0 SCAFFOLD,Fundación Tecnalia Research & Innovation,construction,"Manufacturated nanomaterials and nanocomposites are being considered for various uses in the construction industry and related infrastructure industries, not only for enhancing material properties and functions but also in the context of energy conservation. Despite the current relatively high cost of nano-enabled products, their use in construction materials is likely to increase because of highly valuable properties imparted at relatively low additive ratios, rapid development of new applications and decreasing cost of base MNMs as they are produced in larger quantities.","Innovative strategies, methods and tools for occupational risks management of manufactured nanomaterials (MNMs) in the construction industry",FP7,04 June 2017,05 January 2012,0.0 SCALA,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"The goal of SCALA is the realisation of a scalable quantum computer, by using individually controlled atoms, ions and photons in order to encode, store, process and transmit qubits. This long-term goal is divided into two specific objectives, achievable during the project duration: A) Realisation of interconnected quantum gates and quantum wiring elements, which are required as building blocks of a general purpose quantum computer. B) Realisation of first approaches of 'operational' quantum computing, which include (i) systems able to perform small-scale quantum algorithms, such as error correction (ii) special-purpose quantum processors, such as quantum simulators, and (iii) entanglement-assisted metrology. In order to achieve these objectives, the IP teams will use all the tools and methods of atomic, molecular and optical physics. Experiments will involve strings of individual ions in Paul or Penning traps, arrays of neutral atoms stored in dipole traps, optical lattices or micro-magnetic traps ('atom chips'), and a great variety of cavity QED techniques. In addition, broader theoretical studies will explore the path towards a scalable general purpose quantum computer. The objectives A and B are actually associated with two ways for achieving scalability : a 'bottom-up' route consisting of developing elementary registers, gates and processors, and then networking them, and a 'top-down' route starting with large, strongly interconnected, distributed systems, such as atoms in optical lattices, which are natural candidates for quantum simulators. Combining both approaches is a guiding principle in SCALA, and would be a major achievement for the future of quantum computers. SCALA will be organized to optimize flows of information between the participating teams. The results will be disseminated by scientific publications, and the spin-offs will be exploited by an industrial partner specialized in metrology, and through connections with many SMEs.",Scalable Quantum computing with Light and Atoms,FP6,31 January 2010,31 October 2005,9360000.0 SCALENANO,Catalonia Institute for Energy Research * Institut de Recerca en Energia de Catalunya (IREC),energy,"This project will exploit the potential of chalcogenide based thin film photovoltaic technologies for the development and scale-up of new processes based on nanostructured materials for the production of high efficiency and low cost photovoltaic devices and modules compatible with mass production requirements. Cu(In,Ga)(S,Se)2 (CIGS) chalcogenide based devices have the highest efficiency of all thin film PV technologies, having recently achieved a record value of 20.3% at cell level. These technologies have already entered the stage of mass production, with commercial modules that provide stable efficiencies in the 11-12% range, and a predicted world-side production capacity over 2 GW/a for 2011. However, current production methods in CIGS industrial technologies typically rely on costly, difficult to control (over large surfaces) vacuum-based deposition processes that are known for low material utilisation of 30-50%. This compromises the potential reduction of material costs inherent to thin film technologies. At the forefront of this, the SCALENANO project proposes the development of alternative environmental friendly and vacuum free processes based on the electrodepositon of nanostructured precursors with the objective to achieve a much more efficient exploitation of the cost saving and efficiency potential of CIGS based PV. The project also includes the exploration and development of alternative new processes with very high potential throughput and process rate based in the use of printing techniques with novel nanoparticle ink formulations and new cost effective deposition techniques, that will allow proposing an industrial roadmap for the future generation of chalcogenide based cells and modules",Development and scale-up of nanostructured based materials and processes for low cost high efficiency chalcogenide based photovoltaics,FP7,31 July 2015,01 February 2012,7541468.0 SCIFRI,Universiteit Leiden * Leiden University,information and communications technology,"There is no fundamental law that dictates the necessity of losing energy in a sliding contact. In spite of its apparent simplicity, we have a relatively poor understanding of the mechanisms that determine how energy is lost when two bodies are forced to slide over one another. The SciFri project will launch a research attack on friction that will not only deepen our fundamental insight into this important phenomenon but also involves the development of several strategies to significantly lower or ‘lose’ friction under practical circumstances.",Science Friction,FP7,06 June 2018,07 January 2011,0.0 SCINSCEF,Cardiff University,health,"Millions of people worldwide suffer from spinal cord injury (SCI), with devastating consequences and costs. Various clinical approaches have been attempted to treat SCI with little satisfaction due to the limitation of self-regeneration of axons. Neural stem cell transplantation is an alternative approach with great potential to treat SCI, but the mechanisms controlling migration of implanted stem cells are unclear. A recent SCI clinical trial using implanted electric stimulators to promote axon regeneration showed promising results. However, the mechanism underpinning this technique also remains elusive. We shall investigate genes and molecules regulating the electric fields controlled neural stem cells migration. We have shown before that electric signals play essential roles in directing cell migration during wound healing, and that PI3K and PTEN are critical in the regulation of this event (Zhao, Song et al. Nature 2006). Pax6 and ephrin are also proved to be important in guiding cell migration, however the interactions between PI3K, PTEN and Pax6, Eph-ephrin pathways are unknown. We shall further investigate their potential interactions in this project.. Apart from electric signals, neural stem cell migration can be also regulated by chemical, physical, and haptotactic guidance cues. This project shall use multidisciplinary approaches to combine neural stem cells transplantation with electric stimulation and nanotechnology, to optimize a novel stem cell replacement therapy. We shall use multiple peptide structures to engineer diverse adhesion peptide motifs on the nanofibers, and embed EGF/bFGF into 3D nanofibers scaffold to encapsulate neural stem cells for the transplantation study. These shall be tested in both 2D / 3D in vitro and in SCI animal models in vivo.",Repair Spinal Cord Injury by Controlling Migration of Neural Stem Cells - multidiciplinary approaches of electric stimulation and nanotechnology,FP7,31 December 2015,01 January 2010,1759613.0 SCOMOC,University of Franche-Comte * Université de Franche-Comté,photonics,"The conventional scanning confocal microscopes are bulky bench-top instruments, not appropriate for Lab-on-a-Chip functionality, where size reduction and portability are desired. In many Lab-on-a-Chip applications (e.g. molecule recognition, monitoring of cell growth, investigation of metabolic mechanisms inside the bacteria), there is a strong need to image the molecular features by non-invasive optical methods yielding high spatial resolution and tree-dimensional reconstruction capability. However, the miniaturized imaging systems offering both high resolution and imaging capability are actually not available. The goal of the proposal is the design, fabrication and experimental validation of a miniature Scanning Confocal Optical Microscope on-chip (SCOMOC) for Lab-on-a-Chip applications. The operation of this fully integrated microscope combines the 3-D transmissive steering of VCSEL laser beam by microlens MOEMS scanners, and active signal detection, based on the use of optical feedback in the VCSEL laser cavity. Major challenge includes realization of miniaturised confocal microscope scheme and array-type integration of the microscopes on top of microfluidic network. This proposal has strong multidisciplinary aspects. The realisation of proposal objectives requires advanced knowledge in silicon micromachining, semiconductor lasers, optical sensing and imaging techniques, and microfluidics. The association of photonics and MOEMS technology should make low cost, reliable and massively parallel nano-instrumentation device, matching FP6 objectives.",Scanning Confocal Optical Microscope On-Chip for Lab-on-a-Chip applications,FP6,30 June 2009,01 July 2007,158786.02 SE2A,Texnologies Fotonikon Kai Hlektronikon Systhmatvn AE,information and communications technology,"The societal need for a transport infrastructure based upon the availability of safe, fuel-efficient and environmental-friendly cars is clearly recognized by the European citizens and the European Commission. The fulfillment of this ambition is not to be taken for granted, as it requires the development of a host of automotive technologies, systems, software and tools. It is the objective of this project to create an integrated automotive control platform, enabled by breakthroughs in the areas of efficient fuel consumption, reduced CO2 emission and safe driving, to be achieved by the development of nanoelectronic components, subsystems and architectures.","Nanoelectronics for Safe, Fuel Efficient and Environment Friendly Automotive Solutions",FP7,12 January 2011,01 January 2009,0.0 SE2ND,University of Basel * Universität Basel,information and communications technology,"SE2ND is a joint experimental and theoretical effort. SE2ND strives to develop a highly efficient and continuous solid-state source of spatially separated spin-entangled electrons. A source of this kind, integrated with other electronic elements, will be of great importance in future quantum processors, where they provide, for example, entanglement distribution required to synchronize quantum circuits, and enable secure communication. The project will exploit entangled electron pairs that naturally occur in the ground state of a superconductor. The key target device of SE2ND is an electron-pair splitter with two defining key functions: 1) it ensures that pairs are emitted one by one, and 2) the two electrons of the pair are spatially separated by directing them into two different output channels, while maintaining their entanglement. Both objectives can be realized in carefully tuned double quantum dots. Hybrid double quantum dots will be realized in high-quality low-dimensional materials (semiconducting nanowires, carbon nanotubes and graphene) and integrated together with superconducting injectors, serving as sources of the electron pairs, ferromagnetic elements and microwave cavities in order to assess the degree of pair splitting and electron entanglement. SE2ND will explore the relevant material and fabrication parameters, optimize the splitting efficiency, assess the spin relaxation rate, coherence and the degree of entanglement to provide an optimized source with near to unity efficiency. SE2ND will extensively develop hybrid nanodevices which exploit the unique properties of quantum dots in proximity to superconductors and ferromagnetic materials, thereby providing a novel toolbox for electron-based quantum information technology, helping to maintain Europe at the forefront of this rapidly evolving field.",Source of Electron Entanglement in Nano Devices,FP7,01 July 2017,08 January 2011,2480264.0 SEA-NET,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"Main objective of the IP ¿SEA-NET¿ is to validate emerging semiconductor manufacturing equipment for the 65nm - 22nm nodes, together with advances in equipment for cleaning/etch, handling, metrology/ analysis, modelling/APC and production control for Nanoelectronic CMOS. SEA-NET will strengthen the European equipment industry in a sustainable way by combining advanced RandD with equipment sub-projects involving a wide community of equipment suppliers, users and research institutes. The selection of additional projects will be done in a ¿competitive call¿ starting after 12 months. The equipment companies involved have a high proportion of SMEs who will benefit from their involvement with such organisations and the credibility that results. Joint RandD including; advanced process control capabilities, enhanced wafer and equipment logistics, virtual equipment engineering compliance and control of communication interfaces. Applications will be evaluated for FEOL, BEOL that will improve equipment manufacturing and design criteria thus impacting equipment perfomance and time to maturity. All this will provide ¿progress beyond the current state-of-the-art¿ and lead to cost effective equipment development. Each sub-project will be refined for the progressively emerging technology nodes. This will be done by optimizing the inputs from ITRS and the user requirements as identified within SEA-NET and will provide the benchmark for the assessment metrics. A powerful and flexible management structure is identified for this IP, which has high numbers of; sub-projects, assessment sites, SME´s and users from both, IC-industry and industrially oriented research institutions. The management is structured at the Integrated Project and Sub-Project level. The sub-projects deal with their specific equipment applications/evaluations/own dissemination whilst the IP management covers the independent monitoring of sub-projects and efficient management of the resu",Semiconductor Equipment Assessment for NanoElectronic Technologies,FP6,30 June 2009,30 December 2005,1.124E7 SEA-ON-A-CHIP,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"Early warning systems that can provide extreme sensitivity with exquisite selectivity are required to assess chemical contamination of estuarine and coastal areas. SEA-on-a-CHIP aims to develop a miniaturized, autonomous, remote and flexible immuno-sensor platform based on a fully integrated array of micro/nano-electrodes and a microfluidic system in a lab-on-a-chip configuration combined with electrochemical detection for real time analysis of marine waters in multi-stressor conditions. This system will be developed for a concrete application in aquaculture facilities, including the rapid assessment of 8 selected contaminants from 5 groups of compounds that affect aquaculture production (compounds which are toxic, bioaccumulative, endocrine disruptors) and also those produced by this industry that affect environment and human health (antibiotics and pesticides), but it is easy adaptable to other target compounds or other situations like coastal waters contamination analysis. Each device will be able to perform 8 simultaneous measures in duplicates and it will be build in order to work with one-month autonomy and measuring in real time at least once per hour. As many devices as needed could be connected simultaneously to the same platform resulting in a very flexible and inexpensive system. Sensitivity for Sea-Water analysis is guaranteed thanks to the use of gold microelectrodes arrays with metalocarborane doped functional polypyrrol. Thank to the use of MEMS and microlectrodes in flexible polymeric substrates the costs of production will be reduced. The units will be tested throughout the lifetime of the project and calibrated to state-of-the-art of chemical analytics: first in laboratory studies, second under artificial ecosystems and finally during 3 field experiments in the installation of 2 aquaculture SME facilities. The last test phase will be performed in a way that will include dissemination of the findings with a clear view of commercializing the devices.",Real time monitoring of SEA contaminants by an autonomous Lab-on-a-chip biosensor,FP7,05 July 2019,12 January 2013,5751459.0 SEAM,Royal Institute of Technology * Kungliga Tekniska Högskolan,transport,"Nano-satellites are becoming a reality and are being used for increasingly complex missions. However, to facilitate more advanced scientific missions greater capabilities are needed in terms of mission life-time, communication bandwidth and attitude determination and control. Many science applications of nano-satellites are currently being explored for future implementation, especially in the US, and the SEAM project will ensure that Europe develops the required technology to maintain and strengthen our current leading role in the nano-satellite market.",Small Explorer for Advanced Missions,FP7,10 January 2016,10 January 2013,0.0 SEARCHERS,University of Southampton,transport,"The structure of a molecule or material dictates it properties and provides the key to understanding and enhancing these characteristics for a new generation of functional chemicals. These molecules and materials are central to the future of the EU in terms of enhancing the human environment and maintaining a competitive position for advanced chemicals in areas such as nanomaterials, information technology, aeronautics and space, sustainable development, global change, ecosystems and smart/adaptive functionalities, which have been identified by the EU as priority Thematic Areas in Framework 6. This project will be undertaken by a dynamic team of researchers at the forefront of this subject area who will provide the best training possible for Early Stage Training Fellows (ESTF) in Structural Chemistry. This is be achieved by delivering the following elements Ø access to world leading facilities, both in Southampton and at other European centres, for structure determination and modeling Ø comprehensive training in (a) scientific knowledge through dedicated lectures and courses and (b) generic skills in scientific project management, safety and presentation of knowledge. Ø a research project at the forefront of structural chemistry supervised by world renown scientists Ø excellent opportunities to collaborate on interdisciplinary projects within the University and with key, associated European research centres Ø a structured series of milestones to be reached that leads to the award of the PhD degree for successful researchers EST Fellows trained by this programme will have all the skills and knowledge to undertake scientific research projects central to many disciplines within, for example, chemistry, materials science, environmental science, condensed matter physics and biochemistry.",SOUTHAMPTON EARLY STAGE TRAINING IN STRUCTURAL AND MATERIALS CHEMISTRY,FP6,31 January 2010,01 February 2006,1241754.01 SECM-CRDS,University of Warwick,information and communications technology,"This IIF project aims to bring a top class young female scientist - Meiqin Zhang - from a leading group at Peking (Beijing) University to work on the characterisation and application of a new instrument at Warwick that combines two state of the art techniques: scanning electrochemical microscopy (SECM) and cavity ring-down spectroscopy (CRDS). This instrument has recently been developed in a joint venture between the Warwick Electrochemistry and Laser Spectroscopy groups and we are very excited by its potential. The candidate matches well to the project by having a truly outstanding track record in SECM and electrochemistry which she will be able to develop significantly by being one of the first young researchers to work on the new technique of SECM-CRDS. In essence SECM-CRDS adds a spectroscopic component to SECM for the first time and should be capable of providing considerable new insights into many interfacial processes in chemistry and its borders with the life sciences and materials science. This project will characterise the instrument (spatial resolution, time resolution and chemical sensitivity) and apply it to two major scientific topics: (1) the measurement of lateral proton diffusion along model bilayer lipid membranes and (2) charge transport in conducting polymer films. The first topic is important because this process underpins bioenergetic processes, yet the mechanism and rate of proton transport remains elusive. The second topic relates to understanding how the organisation of conducting polymer films affects charge transport and conductivity, which is important in molecular electronics. In each case we expect to make major advances in understanding due to the exquisitely sensitive nature of the SECM-CRDS technique. This project would ensure that Europe was at the forefront of developments in SECM (of considerable interest throughout the world) and establish links between leading groups in China and Europe (Warwick and its partners).",Combining Electrochemical Scanned Probe Microscopy and CAvity Ring-Down Spectroscopy: A New Direction for the Study of Interfacial Processes,FP6,31 July 2009,01 August 2007,169365.98 SECOQC,AIT Austrian Institute of Technology GmbH,information and communications technology,"Secure communication is an essential need for companies, public institutions and in particular the individual citizen. Currently used encryption systems are vulnerable due to the increasing power of computer technology, the emergence of new code-breaking algorithms, and the imperfections of public key infrastructures. Methods considered as acceptably secure today will have a significant risk of becoming weak tomorrow. On the other hand, with quantum cryptography a technology has been developed within the last decade that is provably secure against arbitrary computing power, and even against quantum computer attacks. When becoming operational quantum cryptography will raise communication security on an essentially higher level. The vision of SECOQC is to provide European citizens, companies and institutions with a tool that allows facing the threats of future interception technologies, thus creating significant advantages for European economy. With SECOQC the basis will be laid for a long-range high security communication network that combines the entirely novel technology of quantum key distribution with components of classical computer science and cryptography. Within the project the following goals will be achieved: - Realisation of a fully functional, real-time, ready-to-market Quantum Key Distribution (QKD) point-to-point communication technology; - Development of an abstract level architecture allowing high security long-range communication by integrating the QKD technology and a set of cryptographic protocols; - Design of a real-life, user-oriented network for practical implementation of QKD based long range secure communication. To achieve this goal, all experience and resources available within the European Research Area are to be integrated and combined with the expertise of developers and companies within the fields of network integration, cryptography, electronics, security, and software development.",Development of a Global Network for Secure Communication based on Quantum Cryptography,FP6,30 September 2008,30 March 2004,1.1352183E7 SEE 2 SENSE,Technische Universiteit Eindhoven * Eindhoven University of Technology,information and communications technology,The goal of the project is to image supramolecular binding processes on the molecular level with the purpose to gain fundamental understanding of how a sensor operates. This understanding will subsequently be applied as a basis for new sensor design.,Image supramolecular binding processes on the molecular level by STM for fundamental understanding sensor,FP7,11 March 2014,09 January 2011,0.0 SELECTNANO,Bar-Ilan University,health,"Metals and moreover nanometallic particles will play a major role in the sustainable growth of European industries such as: chemical, automotive, pharmaceutical, etc. This due to the fact that they offer improved properties in comparison to bulk materials in use. Modernization and leadership in European heavy industry would require development of new nanometallic multifunctional powders with dedicated characteristics. Their development and production will be based on unique innovative methods. SELECTNANO intends to manufacture new metal and transition metal nanoparticles for dedicated new applications, using the novel process, namely - SONOELECTROCHEMISTRY. Sonoelectrochemistry is a new emerging technology .This technique combines electrolysis and sonolysis. The sonication horn serves as a cathode for the electrolysis process and as a transducer releasing US (Ultrasonic) waves. Short electric pulses, which reduce ionic species and deposit the mechanic nanoparticles on the cathode are followed by US pulses causing the nanoparticles to fall to the bottom of the cell. Scientific and technological Objectives: 1. Application of Sonoelectrochemistry for synthesis of multifunctional nanometallic particles 2. Development of new technologies for stabilization of nanometallic particles in different matrices 3. Processes scale up 4. New industrial applications - 4.1 Use of metallic nanoparticles for security issues such as: detection and authentication of articles by printing conductive labels and coding of information based on a printed pattern. 4.2 Nanostructured metallic coating by Cold Gas Dynamic Spray deposition 4.3 Development micron and submicron sized shell structures for release of encapsulated active materials 4.4 Adaptation of the new developments into: High intensity colour pigments; Novel cosmetic ingredients; Nanoscale conductive structuring materials; Novel coating additives",Development of Multifunctional Nanometallic Particles using a New Process - Sonoelectrochemistry.,FP6,28 February 2009,01 March 2005,2725003.0 SELF ASSEMBLY,University of the Basque Country * Universidad del País Vasco / Euskal Herriko Unibertsitatea,manufacturing,"Low-dimensional structures and molecular assemblies in the nanometer range exhibit an enormous potential for applications in future electronic data storage and processing devices. Such structures are particularly interesting when created through the process of self-assembly on suitable substrates. Vicinal surfaces are ideally suited as patterned templates for the mass fabrication of one-dimensional structures on the nanometer scale, where conventional lithographic techniques are no longer feasible or affordable. Vicinal surfaces display a two-fold symmetric morphology and, consequently, a complete anisotropy of all physical properties that is retained upon atom or molecule adsorption and thin-film growth. Furthermore, one-dimensional patterns of steps, facets and atomic rows with periodicities on a scale of 1 nm to 100 nm can be produced. We will investigate the structure and electronic properties of (i) low-dimensional structures (quantum wires, dots, and stripes) and (ii) molecular assemblies of periodic structures prepared on vicinal semiconductor and metal substrates. Our interests are specially centred on the formation and final structure of atomic or molecular chains and their corresponding electronic structure. In the latter case we will focus on the reconstruction of the electron wave functions and the temporal evolution of quasiparticles (holes and electrons), characterised by a finite lifetime that can be analysed by scanning tunnelling and photoemission spectroscopy.",Structure and electronic properties of low-dimensional systems and molecular assemblies,FP6,03 October 2007,04 October 2005,137582.0 SELF-CLEANING GLASS,Saint-Gobain Recherche SA,construction,"Superhydrophobic or hydrophobia coatings have been used in the recent years for several applications, such as easy-to-clean surfaces. Since 2001, photocatalytic self-cleaning glazing have been launched on the European market. These latter products are based on the photocatalytic property of a thin layer of TiU2 deposited at the surface of the glass. When exposed to UVA radiations, TÌ02 reacts with the oxygen and water molecules present in the atmosphere to produce free radicals leading to oxidative species. These species are able to degrade organic stains adsorbed on the surface into volatile molecules. Both technologies gather products designated by the general term of 'self-cleaning'. At the moment, self-cleaning glazing are only tested according to existing appropriate national or international standards to qualify optical and energetic properties. In building applications for example, these new glazing must pass the EN-1096 standard. But there are no certified nor normalized tests to evaluate the self-cleaning performances of these products. hi order to define appropriate tests for the self-cleaning properties of nano-structured surfaces, the project will be based on three main achievements. - The acquisition of a thorough understanding of the real soiling mechanisms at microscale level on glass and self cleaning coated glass. - The enhancement of fundamental knowledge on the interactions between self cleaning coating ability and pollutants, occurring at a nano scale level. The development of measurement methods for self cleaning ability and the carrying out of a prenormative study on glass soiling and self cleaning glass. A certification test definition for self-cleaning properties, based on the benefits they bring to customers will be provided.","Nano-structured self-cleaning coated glasses: modelling and laboratory tests for fundamental knowledge on thin film coatings, EC normalisation and customer benefits",FP6,28 February 2007,01 March 2004,2292584.0 SELFBIOLOGICS,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"Whether a cell adheres to the extracellular matrix, or biological signals propagate within and between cells, highly selective interactions occur between the molecular 'partners' that materialize the process. Supramolecular chemistry studies the basic features of these interactions (knowledge) and their implementation for the design of non-natural systems (technology). This field bridges molecular chemistry and physics with biology, providing a interdisciplinary platform to understand biological structure (self-assembly) and function (recognition, reactivity and transport). Peptides that self-assemble in ordered nanostructures are a particular case of supramolecular chemistry. Peptides possess the biocompatibility and chemical diversity found in proteins, being particularly interesting for regenerative medicine and nanomedicine. Until now, peptide self-assembly systems have been studied individually. However, biological structures form in highly dense and heterogeneous molecular environments, such as the cytosol and extracellular matrix. The main scientific objective of this project is to recreate part of this complexity, by creating multi-component peptide self-assembly systems that form independent nano-assemblies in the same physical space. These systems will be used to provide technological solutions for the regeneration of ischemic neuronal tissues (artificial extracellular matrix) and the refined release of growth factors (capsules). These systems are also designed to be intermediate steps towards much more challenging future career objectives, namely cell-like bioreactors with the ability of protein production, self-maintenance or, even, self-replication. The beauty of this endeavor is that in the way towards such challenging scientific objectives, quite promising technological solutions can be derived, benefiting mankind health and welfare in ways that at the moment can just be painted with the faint colors of our imagination.",Mimicry of biology supramolecular logics towards self-assembly of artificial components for life,FP7,31 March 2014,01 April 2011,246360.0 SELFCHEM,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),manufacturing,"Today, one of the greatest challenges facing physics, chemistry, and (bio)materials science, is to precisely design molecules so as to program their spontaneous bottom-up assembly into functional nano-objects and materials, based on recognition and self-organization processes. Beyond that, in order to reach higher-performing new materials and to bridge the gap between materials science and life science, it appears essential to bring together both multiple responsive levels of hierarchical organization and time-dependent processes.",Information Transfer through Self-organization Processes in Systems Chemistry,FP7,10 July 2017,11 January 2010,0.0 SELFCLEAN,National Technical University of Athens,health,"Hygiene/antimicrobial issues in public places (hospitals, schools, hotels, public transportation etc) are of crucial importance as inattention could lead to spread of viral diseases or epidemics and consequently to deaths. A typical example is that of hospital acquired infections (HAI). According to The European Centre for Disease Prevention and Control (ECDC) in the EU, about 3,000,000 are infected annually with HAI and about 25,000 patients die from this. Such infections also bring extra healthcare costs and annual productivity losses of at least €1.5 billion. It is estimated that 15% of these infections is due to transmission through inanimate objects. Although sanitization and disinfection of surfaces using chemical liquids as chlorine or alcohol is a common practice to prevent transmission of diseases, many times such procedures are skipped, skimped or in the case of public transportation not practically feasible. There exists a great need for anti-bacterial/viral surfaces to reduce the spread of diseases. The SMEs of the consortium having identified this need propose the solution of self-cleaning, antibacterial electrolytic coatings of high aesthetics and durability. These composite coatings will consist of Sn-Ni matrix with doped TiO2 nanoparticles as a reinforcing mean. Doped-TiO2 nanoparticles having the ability to absorb visible light can be activated indoors and thus present enhanced photocatalytic activity. The incorporation of these doped-TiO2 nanoparticles in the Sn-Ni matrix will have as a result the self-cleaning and antibacterial properties. Of crucial importance is the percentage of the incorporated nanoparticles. In order to increase the co-deposition rate and consequently the photocatalytic activity, pulse current plating will be utilized. With this method higher co-deposition rate of nanoparticles can be achieved compared to the conventional direct current plating. These kind of coating will be able to operate under indoor light irradiation and can be applied to common touched objects (knobs, taps, handles) reducing the risk of infection's transmission by 50-100%.","Novel Self-cleaning, anti-bacterial coatings, preventing disease transmission on everyday touched surfaces",FP7,28 February 2015,01 March 2013,1139000.0 SELFMEM,Centre for Materials and Coastal Research * Helmholtz-Zentrum Geesthacht – Zentrum für Material- und Küstenforschung GmbH,environment,"The aim of SELFMEM is to develop innovation in the field of nanoporous membranes. This will be achieved by taking advantage of the self-assembly properties of block copolymers leading to highly porous membranes with adjustable, regular-sized pores of tailored functionalities. Both polymeric and inorganic (silicon) membranes will be developed. In the case of isoporous polymeric membranes focus will be laid on the formation of integral-asymmetric block copolymer membranes with an isoporous top layer as a function of the block copolymer structure and the preparation conditions. Isoporous inorganic membranes will be prepared by using a thin block copolymer film as a mask for selective etching. The possibilities to systematically vary the pore size and density by varying the block copolymer mask structure will be investigated. The block copolymers will be synthesized by controlled polymerisation techniques (anionic, group transfer, and different radical polymerisations), depending on the chosen monomers. The characterisation during and after formation of the membranes will be carried out by light and various x-ray scattering techniques, by scanning force microscopy, and by different electron microscopic techniques. Both types of membranes will be post-functionalized in order to tune their final properties. The membranes will be tested for their applicability in different areas. Separation of gases (like H2/CO2) and proteins as well as water purification will be addressed in this project. Modeling and theory will support the understanding of the structure formation of these membranes and help to optimise membrane design. The results of SELFMEM will increase European competitiveness in strategic markets such as gas purification, water treatment and molecular biology. The consortium consists of 12 partners from 10 countries, including 4 companies from 3 countries.",Self-Assembled Polymer Membranes,FP7,08 July 2014,09 January 2009,3599734.0 SELFPHOS,University of Regensburg * Universität Regensburg,manufacturing,"In view of current developments in the fields of porous materials and discrete nano-sized molecules and aggregates the lack of organometallic-based compounds acting as nodes together with functionalized organic linkers in such materials and as linkers and building blocks for nano-sized spheres and aggregates is obvious. By using organometallic polyphosphorus compounds it was possible to synthesize unprecedented prototypes of such materials and molecular nano-sized superspheres. These ground-breaking discoveries will be subsequently further developed to excess a qualitatively novel level of research by using polypnictogen starting materials. Key targets will be the generation of rigid 3D organometallic-based materials, discrete supramolecular nano-sized aggregates (charged moiety approach) and novel fullerene-like supramolecules as nano-spheres, nano-capsules and nano-wheels (neutral moiety approach). Especially the latter approach will generate unprecedented spheres and molecules which are extreme in size and function as there are multifunctional binding sites; multi-magnetic properties; tuning templates in size; generating, encapsulating and releasing highly reactive intermediates and reaction components. Finally, the work will move beyond our knowledge of known structurally characterized fullerenes by the development of non-carbon based alternatives within and beyond the fullerene topology.",Design and Self-Assembly of Organometallic-Based Polypnictogen Materials and Discrete Nano-sized Supramolecules,FP7,01 July 2021,02 January 2014,2499853.0 SEMANTICS,Trinity College Dublin,energy,"We will develop simple, scalable methods to exfoliate layered compounds into monolayer nanosheets. These materials have exciting properties. Recently, graphene has taken the nanomaterials community by storm. However graphene is only one branch of a family of two dimensional layered compounds. Other examples include hexagonal BN, metal dichalcoginides such as MoS2 and metal oxides such as MnO2. We propose that all layered compounds can be exfoliated in certain solvents by the addition of ultrasonic energy. Such a method has not been demonstrated because the vast majority of solvents are unsuitable for this. We propose that suitable solvents can be identified by matching their surface energy to that of the nano crystal, rendering the exfoliation process energy neutral. This will open the gate to a wide range of nano-materials science and makes possible experiments that have been impossible using standard techniques. We will pick a set of layered compounds such as the semiconductors; hexagonal BN, MoS2 and TaO3 and the metals TaS2 and MnO2. We will learn to exfoliate these materials, studying the physics and chemistry of the solvent-nanosheet interaction. Once we can generate large volumes of highly exfoliated nanosheets at high concentration, we will study the physics of these materials. We will start at the macroscale, preparing free standing films of restacked sheets and polymer-sheet composites for mechanical applications. Thin films can also be studied as transparent conductors and capacitor dielectrics. Hybrid films can be used to study electroluminescence or photovoltaic action. At the nanoscale, single BN layers would make ideal gate dielectrics for monolayer MoS2 transistors. In addition overlapping layers of MoSe2 and MoTe2 could make atomic scale solar cells. Overlaying TaS2 and MnO2 sheets on either side could act as the electrodes. Thus these materials represent a nanoscale playground to study mechanics and electronics on scales from nano to macro.",Semiconducting and Metallic nanosheets: Two dimensional electronic and mechanical materials,FP7,30 September 2015,01 October 2010,1405632.0 SEMINANO,Middle East Technical University * Orta Doğu Teknik Üniversitesi,photonics,"The primary objective of this project is to develop fundamental knowledge on the production techniques, characterization and methods of applications of semiconductor nanocrystals to light emitting devices and floating gate memories. Three main research directions can be identified in the project : First, physics and chemistry of a number of elemental, alloy and compound semiconductor nanocrystal formation and mechanisms of charge tranport and light emission will be studied in a systematic way to acquire fundamental knowledge. Second, methods and technology of obtaining new materials with well characterized nanocrystals suitable for use in device work will be developed.Finally, devices such as Metal Oxide Semiconductor (MOS) for use in flash memories and light emitting devices (LEDs) will be designed, fabricated and tested as prototypes of devices incorporating the unique features of nanocrystals. Full cycle starting from material processing to the demonstration of devices will be covered. Different materials, production techniques, processing conditions and characterization techniques will be employed to reach comprehensive results for the science and technology of semiconductor nanocrystals. As its main objectives are strongly related to the size dependent phenomena in semiconductors and its outcomes will form the basis for the new production techniques in the modern microelectronic and photonic industry, this project addresses topics with the following activity codes of NMP Work Program: 3.4.1.1. , 3.4.3.1.The project has been broken into 3 main workpackages : WP1 deals with the Si and Ge nanocrystals prepared in different media and processed by various techniques. WP2 is related to the production and characterization of some alloy and compound semiconductor nanocrystals. WP3 deals with the application of the materials studied in the first two workpackages to the devices mentioned above.","PHYSICS AND TECHNOLOGY OF ELEMENTAL, ALLOY AND COMPOUND SEMICONDUCTOR NANOCRYSTALS: MATERIALS AND DEVICES",FP6,31 August 2007,01 September 2004,2219556.0 SEMISPINNANO,University of Nottingham,information and communications technology,"The proposed research programme addresses important issues in the field of ferromagnetic semiconductor spintronics which are of fundamental and potential technological importance. At the core of the project are the objectives of measuring the carrier spin polarisation in ferromagnetic semiconductors (a key quantity for spintronics) and of producing nanoscale ferromagnetic semiconductor single electron transistors which promise new spintronic functionalities. The applicant and the host Semiconductor Spintronics Group are uniquely matched to make this timely and important project possible. The applicant is an expert in the field of superconductivity and its interplay with magnetism who has extensive experience of focused ion beam nano-patterning and Point Contact Andreev Reflection spectroscopy, which makes possible the measurement of spin polarisation. The host Semiconductor Spintronics Group are internationally-leading in the field of ferromagnetic semiconductor materials and device development. This research project is very complementary to, but clearly differentiated from, existing research projects at Nottingham. In essence the intention is for the applicant to apply her particular expertise and techniques to materials fabricated at Nottingham for the realisation of important advances in semiconductor spintronics, thus greatly benefiting applicant and host institution.",Semiconductor Spintronics: Spin Polarisation and Nanodevices,FP7,03 July 2013,04 January 2009,181350.76 SEMISPINNET,University of Nottingham,information and communications technology,"We propose an Initial Training Network for advanced nanoscale semiconductor spintronics. This is a coordinated programme of technological, experimental and theoretical research, training and knowledge transfer, by a consortium of leading European academic and industrial research groups. Spintronics is becoming increasingly important as downscaling and power usage in microelectronics approaches fundamental limits. This ITN will provide a framework for structuring research and training efforts in this field and exploiting the new technology. The programme will move well beyond the worldwide state-of-the-art, through development of novel multifunctional nanospintronic devices, by transfer of device concepts to room temperature operation, and by exploration of the potential of low-dimensional systems. This coordinated wide-ranging and multidisciplinary programme is only achievable through a cross-European approach. The ITN will supply the required multidisciplinary and intersectorial training in materials development, device physics and technology and theory, which is crucial for ensuring a highly developed research infrastructure and a critical mass of qualified researchers in this key research area. Researcher mobility will be encouraged, with all appointed fellows spending periods at academic and industrial hosts. Industrial partners will be central to the training programme, ensuring that fellows have an understanding of the needs of end-users of the research. Transferable skills training will be supplied to meet wider employment market needs. The proposal is highly relevant to the ITN objectives, the Information Society Technologies and Nanotechnologies thematic areas of FP7, and ERA strategies to network centres of excellence, increase researcher mobility, and improve cohesion in research. The ITN will provide a body of highly skilled scientists, equipped with the expertise to ensure that European research continues to flourish in this vital area.",Initial Training Network in Nanoscale Semiconductor Spintronics,FP7,11 June 2014,12 January 2008,3209394.84 SEMOFS,Chemnitz University of Technology * Technische Universität Chemnitz,health,"The aim of the SEMOFS project is to develop a radically new concept for biosensors: a polymer-based card type integrated 'Plasmon enhanced SPR'-sensor. The card will combine biologically active surfaces with integrated optics (light source, detection ) and biocompatible multichanel micro-fluidics. The project aims to achieve a significant breakthrough, since all functions will be totally integrated on a single polymer-based chip. The final product shall be manufactured with large scale, mass production techniques. The card will therefore be extremely low cost and disposable while providing increased sensitivity and diagnosis possibilities. The project will focus on: - Nanotechnology based biosensing concept 'Plasmon enhanced SPR' - increases detection sensitivity and access to new information of the biological sample - Micro fluidics on polymer substrate enabling multichanneling (further enhancing sensitivity by parallel analysis) and integrated fluid actuators. - Integrated optical detection concept based on Organic Light Emmitting Display (OLED)/waveguide/miniaturised spectrometer enabling card type integrated solution and multi-channelling. - Hybrid micromachining to ensure compatibility of the mastering and replication protocols with constraints of industrial scale manufacturing. - Validation of expected applications and Evaluation of clinical viability - Cancer diagnosis. The consortium of the SEMOFS project involves 9 partners from 6 EU countries (B, DK, CH, D, F, UK). REC: CEA (Surface functionalisation and biochemistry, encapsulation), CSEM (Micro Optics); HE: Chemnitz University (Micro Fluidic, technical coordinator), Cardiff University (Production technologies / micro machining); 2 SME's: Eurogentec (Biological probes/targets), Bayer (Schweiz) ex. Zeptosens (Bio sensing solutions); IND: SMB (Up-scaling of the micro fluidics components) and OTH: Centre Hospitalier Regional de la Citadelle (Medical expertise, pre-validation test on short population of",Surface Enhanced Micro Optical Fluidic Systems,FP6,28 February 2009,28 August 2005,1899956.0 SENFED,Technical University of Munich * Technische Universität München,photonics,"Nanowires are filamentary crystals with a very high ratio of length to diameter, the latter being in the nanometre range. From a fundamental point of view, semiconductor nanowires are of significant interest because they exhibit new physical and chemical properties owing to their large surface-to-volume ratio, low dimensionality and confinement in one dimension. From a technological perspective, they constitute attractive building blocks for the assembly of novel nano-electronic and nano-photonic systems, as well as biochemical sensors. This proposal combines three complementary aspects of semiconductor nanowires: synthesis, characterization of their structural, optical and electronic properties, and application to field effect devices. All three aspects will run semi-simultaneously in and inter-related way. The synthesis oriented part of the project will concern the study of the growth mechanisms of nanowires, the synthesis with alternative catalysts and the understanding of the synthesis of new crystalline structures. In parallel with the synthesis studies, the optical and electronic properties of the nanowires at low temperatures will be fully characterized. In order to deterministically dispose the nanowires on a substrate, for the adequate electrical characterization, the fabrication of horizontal porous alumina as templates for nanowires will also be studied. Finally, the initial results and methodologies will be combined to the realization of field effect devices, both electrically and chemically gated.",Semiconductor Nanowires and Their Field Effect Devices,FP6,30 September 2010,01 October 2006,1020792.39 SENSATION,"Centre for Research & Technology, Hellas * Ethniko Kentro Erevnas Kai Technologikis Anaptyxis (CERTH)",health,"Sleep loss, excessive fatigue, stress and inattention constitute the social diseases of our century. Within the '24 hour society' people tend more and more to exchange sleep and serenity for gain or pleasure. This gradually leads to an excessive rate of sleep disorders, roughly 20% of the population suffer from one, at least mildly or temporarily, as well as to a boom of stress and anxiety related diseases. In addition, a significant percentage of severe traffic and industrial accidents seem to be caused by the involuntary human transition from wakefulnessto sleep or by prolonged inattention. SENSATION aims to explore a wide range of micro and nano sensor technologies, with the aim to achieve unobtrusive, cost-effective, real-time monitoring, detection and prediction of human physiological state in relation to wakefulness, fatigue and stress anytime, everywhere and for everybody.Thus, the different states of human brain are analysed within SubProjectl. Big databases with recordings of normal and involuntary (during task-execution) transition from wakefulness to sleep from hundreds of people will be created to serve as development and reference basis. In Subproject 2, 17 micro sensors and 2 nano sensors are developed. They include brain monitoring, wearable, eye-related posture and motility and autonomie functions sensors; all wirelessly integrated through a body/local/wide area network. These sensors are combined into medical systems for medical diagnosis and treatment within Subproject 3. They will be also integrated in a system for operator's hypovigilance detection and prediction, to be used in various industrial operations and environments within Subproject 4. The overall IP is coordinated by a series of cross-project activities within Subproject 5, which cover management, training, system architecture, dissemination, evaluation, exploitation, user awareness enhancement, standardisation, ethical and legal issues.","ADVANCED SENSOR DEVELOPMENT FOR ATTENTION, STRESS, VIGILANCE and SLEEP/WAKEFULNESS MONITORING",FP6,30 April 2008,30 December 2003,9999960.0 SENSBIOSYN,Biosensor Srl,health,"The purpose of this 2-years project is to develop sensors and biosensors for on-line monitoring growth parameters of industrial bioprocesses for the production of algal biomass and antioxidant compounds such as Xanthophylls. As a model for the design and in-field testing, the following industrial process and culture system have been selected: the natural production of Astaxanthin from the green microalga Haematococcus pluvialis in a tubular photobioreactor. Key parameters such as biomass, pigment content and accumulation profile during the induction process are now experimentally determined offline everyday at commercial production sites by means of complex manual analyses. This routine monitoring further increases production costs, being critical time consuming and requiring manpower. This is a major challenge faced by microalgae companies today, especially in the production of natural carotenoids in comparison with the relatively cheap synthetic analogues. SENSBIOSYN intends to offer a solution to the lack of existing devices able to provide online rapid automatic and reliable information on active compounds accumulation profile and efficacy during their biosynthesis. The proposed project will bring the following competitive advantages to microalgae companies: Increased production - online monitoring will ease decision about time of harvest and culture performance; Reduction of production cost - the introduction of the proposed biosensors in the process control will allow to save work time and manpower and reduce the production cost by at least 30%, which is a big industrial breakthrough. Two optical sensors, for chlorophyll fluorescence measurement and culture medium density, and two electrochemical biosensors, based on the direct measurement of Phosphatidylcholine peroxidative damage by screen printed electrodes and the PSII activity by nanowire FETs, will be manufactured.",Biosensors and Sensors for the industrial biosynthesis process of widely used commercial antioxidants: nutraceuticals as additives for food and aquaculture promoting public health and safety.,FP7,31 October 2011,01 November 2009,945860.0 SENSHY,nanoplus Nanosystems and Technologies GmbH,photonics,"The SensHy proposal focuses on novel photonic gas sensors for the detection of hydrocarbons. Hydrocarbons can be detected most sensitively in the 3.0 to 3.6 µm wavelength range. Two particular challenging applications with significant market potential are investigated within the project. Unfortunately there are no application grade semiconductor lasers in this wavelength range yet: On the short-wavelength side of this range interband lasers are available (RT cw operation for emission up to about 3.0 µm), while intraband quantum cascade lasers were demonstrated on the long-wavelength side (RT cw operation for emission above about 3.8 µm). An additional complication for applications in gas detection is given by the maximum available tuning range for suitable mono mode laser diodes, which is currently limited to a few nanometers. Concepts for an increased tuning range have so far been predominantly investigated at wavelengths around 1.55 µm for telecom applications. The aim of the SensHy proposal is to overcome these limitations and to achieve the following goals: - realize GaSb based laser material enabling RT cw operation in the wavelength range from 3.0 to 3.6 µm - develop multi-section DFB/DBR Lasers with increased electrical tuning capability - demonstrate highly sensitive hydrocarbon detection making use of widely tuneable lasers and novel digital-signal-processing schemes to identify various gas constituents within a multi-component hydrocarbon gas mixture In order to reach these goals significant challenges have to be overcome in various fields ranging from epitaxial semiconductor growth via laser design and processing to mid infrared sensor development of the project. For this the consortium comprises renowned research groups, academic and industrial partners including SMEs from across Europe with a range of complementary competencies covering all aspects from semiconductor material and characterization to photonic components and sensor systems.",Photonic sensing of hydrocarbons based on innovative mid infrared lasers,FP7,29 August 2011,01 March 2008,2350000.0 SENSINDOOR,Saarland University * Universität des Saarlandes,information and communications technology,"SENSIndoor aims at the development of novel nanotechnology based intelligent sensor systems for selective monitoring of Volatile Organic Compounds (VOC) for demand controlled ventilation in indoor environments. Greatly reduced energy consumption without adverse health effects caused by the Sick Building Syndrome requires optimized ventilation schemes adapted to specific application scenarios like offices, hospitals, schools, nurseries or private homes. These must be based on selective detection and reliable quantification of relevant VOCs such as formaldehyde or benzene at ppb or even sub-ppb levels in complex environments. Priority scenarios and corresponding target gases and concentrations will be defined together with an advisory board representing health standard experts and major industrial stakeholders. The project addresses two sensor technologies with MEMS-based metal oxide semiconductor gas sensors and SiC-based gas sensitive field effect transistors. Gas sensitive layers for both sensor technologies are realized by Pulsed Laser Deposition for well-defined, stable and highly sensitive nanostructured layers. These are combined with gas pre-concentration to boost the sensitivity of the overall system. Dynamic operation of the gas sensor elements by temperature cycling combined with pattern recognition techniques is employed to further boost sensitivity and selectivity and expanded to optimally use the gas preconcentration. The project thus combines physical and chemical nanotechnologies for extremely sensitive and selective gas sensing, MEMS technologies for low-power operation as well as low-cost manufacture and finally dynamic operating modes together with advanced signal processing for unrivalled system performance. Sensor elements and systems are evaluated under controlled lab conditions derived from priority application scenarios. The final demonstration of the SENSIndoor technology will include field tests with sensor systems integrated into building control systems.",Nanotechnology based intelligent multi-SENsor System with selective pre-concentration for Indoor air quality control,FP7,12 July 2018,01 January 2014,3399995.0 SENSING FORUM,Linköping University * Linköpings Universitet,information and communications technology,"The proposed 'Sensing Forum' at Linkoping University, Sweden, is primarily built on two existing organizations. Forum Scientium that is a multidisciplinary graduate school within Life ScienceTechnologies and Biomedicine with an emphasis on Sensing Science, and S-SENCE that is a Swedish Centre of Excellence in Bio- and Chemical Sensor Science and Technology. The research in the early stage training programme is chosen to allow a multidisciplinary approach to scientific questions within the sensing science area. The main research area concerns multisensorsystems, e.g. electronic noses and electronic tongues. In these, signals from sensors with different sensitivities are combined to a response pattern specific for e.g. an odour. Biosensors based on synthetic peptides, as well as DNA and protein arrays using molecular electronics are examples of research projects well aimed for the students participating in the proposed programme. The work includes both exploratory projects as well as application driven projects with industry. In all areas there are ongoing high-level research, which will secure that a fellow choosing to work in any of these areas, will be given excellent supervision and support. All students in the training programme will take part in the regular activities of the graduate school in which altogether 57 PhD-students have so far been admitted. Of these five were/are from other European countries than Sweden. It has also hosted so far seven students participating in the Marie Curie Training Site that started here during end of year 2000. In the beginning of 2004, there are 22 PhD-students in the graduate school. All activities are done using the English language. Examples are weekly meetings, study visits to interesting companies, interesting seminars, trainees at other laboratories, summer schools, and common PhD-courses.",Forum Scientium Sensing Science Early Stage Research Training Centre,FP6,31 August 2008,01 September 2004,927403.0 SENSNET,Department of Information Engineering - University of Padua * Dipartimento di Ingegneria dell'Informazione - Università degli Studi di Padova,information and communications technology,"Dramatic advances in MEMS, DSP capabilities, computing, and communication technology are revolutionizing our ability to build massively distributed, easily deployed, self-calibrating, disposable wireless sensor networks. Soon, the fabrication of inexpensive millimeter-scale autonomous electromechanical devices containing a wide range of sensors including acoustic, vibration, pressure, temperature, humidity, magnetic, biochemical, will be readily available. These potentially mobile devices, provided with their own microprocessor and power supply, will be able to communicate with close neighbor sensors devices via low-power wireless communication, and forming a wireless sensor networks with up to 100,000 devices. Sensor networks can offer access to an unprecedented quality and quantity of information. This information can revolutionize an individual’s control of the environment, and their ever-decreasing cost will make sensor networks ubiquitous in many aspects of our lives. These include home-automation, environmental monitoring, transportation systems, automotive control, autonomous systems for space exploration, and manufacturing automation. Our project will consider the control issues and requirements arising from distributed control applications which exploit large sensor networks for the monitoring and control of large, rapidly changing environments. In contrast to the current research trend, which is mainly concerned with the co-development of hardware and software tools for the rapid prototyping of software, we will focus on defining a language that will describe the tradeoffs between computation, communication, energy usage, and control accuracy. The main innovative claims that will be generated from this project include (1) development of new concepts and tools for the abstraction and analysis of sensor networks, (2) design of control systems under communication constraints, and (3) real-time processing of distributed sensory data.",Analysis and design of large scale sensor networks for distributed control applications,FP6,30 June 2007,01 July 2005,80000.0 SEPON,National Research Council * Consiglio Nazionale delle Ricerche (CNR),manufacturing,"Oxide nanostructures in low dimensions on well-defined metal surfaces form novel hybrid systems with tremendous potential and impact in fundamental research and for the emerging nanotechnologies. The focus of the project is on the fabrication of two-, quasi-one-, and quasi-zero-dimensional oxide nanostructure model systems suitable for elucidation of their emergent properties in terms of structure, electronics, magnetism, and catalytic chemistry. This will be achieved by controlled self-assembly in ultrahigh vacuum, with atomic-scale precision, and in-situ characterisation employing the full palette of modern surface science methodology. Established kinetic preparation routes as well as a new approach to steer the self-assembly via external fields will be applied to the growth of a variety of transition metal oxides on suitable substrate surface templates. The stabilisation mechanism of polar oxide surfaces in nanoscale oxide objects, the catalytic chemistry of a nanoscale inverse model catalyst consisting of oxide nanowires coupled to an array of one-dimensional metal step atoms, and the magnetic properties of a surface-supported oxide quantum dot superlattice will be among the emergent phenomena to be probed in this project. Such fundamental questions will be addressed in a close collaboration between state-of-the-art experimental and theoretical techniques. The possibility to separate dimensionality from nanoscale effects made possible by the model systems created here will add an extra dimension in the understanding of oxide nanophase systems.",Search for emergent phenomena in oxide nanostructures,FP7,11 June 2015,12 January 2008,2026800.0 SEQUOIA,III-V Lab,photonics,"Silicon photonics is a powerful way to combine the assets of integrated photonics and CMOS technologies. The SEQUOIA project intends to make significant new advances in silicon photonic integrated circuits by heterogeneously integrating novel III-V materials, namely quantum dot and quantum dash-based materials on silicon wafers, through wafer bonding. Thanks to the superior properties of those innovative materials, hybrid III-V lasers with better thermal stability, higher modulation bandwidth and the possibility of generating a flat wavelength-division-multiplexing comb will be demonstrated. Moreover, the hybrid integration of nano-structured materials on Si allows to exploit the advantages provided by silicon. In particular, optical filters can be directly integrated with hybrid quantum dot/quantum dash/Si lasers to create chirp-managed lasers, which have an enhanced modulation bandwidth and extinction ratio compared to directly modulated lasers. As an illustration of the technology developed in SEQUOIA, transmitters with a total capacity of 400 Gbit/s (16x25 Gbit/s) will be designed, fabricated and characterized. The hybrid integration of nano-structured III-V materials in silicon through a wafer bonding technique is generic, and the concepts and technology developed inside the SEQUOIA project can be further extended to other types of transmitters, for example with extended link range, higher bit rate, higher WDM channel number and other types of modulation formats. In addition, a broad range of applications, such as sensing, health-care, safety and security, can benefit from the technology developed in SEQUOIA.The SEQUOIA consortium is highly complementary, covering all skills required to achieve the project objectives, from the growth of the nano-structured materials to the assessment of high bit rate digital communication systems, and has the potential to set up a comprehensive supply chain for the future exploitation.",Energy efficient Silicon transmittEr using heterogeneous integration of III-V QUantum dOt and quantum dash materIAls,FP7,30 September 2016,01 October 2013,3330000.0 SESBE,CBI Concrete Institute * CBI Betonginstitutet AB,construction,"There is a vastly growing demand for increased energy efficiency, safety and improved health of the buildings we live and work in. These demands need to be addressed by a mostly SME oriented building industry, which traditionally responds sluggish to technological advancement. This is partially due to restrictive building codes, which all too often delay new developments but also because the cost and time pressure on the building sector gives SMEs not much room for technological development and the implementation of innovation. The SESBE consortium, consisting of three SMEs, four industrial and five research partners, addresses this and will provide new solutions for lightweight, energy efficient and safe façade elements. For the first time nanomaterials and nanotechnology are suggested for this type of application. It will be used as a tool to custom design functional and performance properties of façade sandwich elements for new constructions and half elements for refurbishment of existing buildings as well as a new type of sealing tape and intumescent coating for fire protection. It is highly expected, the new solutions will have a significant impact on the building sector, not only commercially and societal but also giving impulses to SMEs to invest more in innovation and to partner-up with competent research partners whenever possible. This approach could be a role model for the partnership of research, industry and SMEs in achieving the mutual goal of making housing sustainable, energy efficient, affordable, safe and healthy.",Smart elements for sustainable building envelopes,FP7,01 July 2019,08 January 2013,3482745.0 SESQ.COM,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"The development of efficient sources of single photons is a major challenge in the context of quantum communications and quantum information processing. The state-of the art solid state based single photon sources (SPS) are based on III-V quantum dots embedded in micropillar cavities. Despite intensive research two main challenges remain to date: First, the efficiency of single photon generation is low, due to the limitations in efficient micropillar output coupling. Second, the degree of indistinguishability of the photons obtained is insufficient for practical applications. Here we propose to address both of the aforementioned challenges. In a first research phase single photons will be generated using quantum dot embedded in photonic crystal microcavities. In a second phase, a novel approach will be introduced in order to significantly increase the SPS efficiency; a quantum dot microdisk will be directly coupled to an optical tapered fiber. These novel SPS should should find utilisation in cascadable quantum gates and quantum information systems or in experiments on the fundamental concepts of quantum mechanics, two areas that mobilize the international physics community and in which Europe has a lead. The training aspects of the project involve a significant enlargement of the scientific field of the applicant into a fast-advancing new area of quantum optical devices, acquisition of cutting-edge nanofabrication technical skills, and the development of project management and apprentice guidance methods, essential for an independent research career. The hosting institution is the Laboratory for Photonics and Nanostructures (LPN), the main French nanofabrication facility and one of the leading laboratories in nanofabrication and quantum optics worldwide.The applicant is a German scientist, with Ph.D. training at Caltech in the USA, returning to Europe to launch his career and choosing LPN and the scientific opportunities it provides, as his entry point.",Spontaneous Emission of Semiconductor Quantum DotsControlled in Optical Microcavities,FP6,31 July 2008,01 August 2006,153072.37 SETNANOMETRO,Istituto Nazionale di Ricerca Metrologica (INRIM),health,"According to European Commission [EC, COM (2012) 572, 3.10.2012] important challenges at European level are related to the establishment of validated method and instrumentation for detection, characterization and analysis of nanoparticles. In the framework of the SETNanometro project, the use of various measurement techniques for the determination of the NPs properties will allow to move from the currently used 'trial and error' approach toward the development of well defined and controlled protocols for the production of TiO2 NPs. A particular care will be devoted to the establishment of correct metrological traceability chain in order to ensure the reliability of the results. The lack of international measurement standards for calibration is an aspect of particular relevance in nanotechnologies as it is difficult to select a universal calibration artefact to achieve repeatability at nanoscale. The materials produced according to such procedures, will be hence sufficiently characterised and homogeneous in their properties to become candidate Certified Reference Materials to be used in various applications where the lack of metrological traceability is encountered. The project results are expected to lead to fundamental impacts on the following areas: Environment: the increased knowledge of TiO2 NPs will improve the photocatalytic properties for the treatment of pollutants in air and water Energy: the better knowledge of dimension and electronic structure of TiO2 will allow to improve the traceability of DSSC measurements. Health: the engineering of topographic and surface composition of TiO2 nanostructured coatings of orthopaedic and dental prostheses will support the design of rules for the production of devices exhibiting otpimized interfacial properties for a better and quicker integration of the implants in the hosting bone tissues.",Shape-engineered TiO2 nanoparticles for metrology of functional properties: setting design rules from material synthesis to nanostructured devices,FP7,31 March 2017,01 December 2013,4349462.0 SFINX,Lancaster University,information and communications technology,"We propose to launch an exhaustive investigation of hybrid nanostructures incorporating superconducting (S) and ferromagnetic (F) metal components. We will investigate experimentally and theoretically fundamental quantum electronic and magnetic phenomena occurring in superconductor and ferromagnet-based hybrids, dynamic and kinetic transport effects, the processes of spin filtering and spin injection, and the possibility of coherent manipulation of an individual electron spin. In the course of this work, we shall master the metal- ferromagnet interface technology, and develop techniques for manufacturing micron and submicron-size circuits. The exciting new feature of S-F hybrid structures consists of the competition between ferromagnetism and superconductivity, representing two antitheses in condensed matter physics, which is of abiding interest in fundamental and applied materials science and occurs naturally only in few exotic materials. Now we aim to produce it artificially in nano-structured composite materials, such as S-films with embedded magnetic nano- clusters, in S-F-S and F-S-F multi-layers, and in sub-micron size hybrid circuits. The mutual proximity between superconductivity and ferromagnetism, possible as these are brought together within a nanometre scale, will create new quality with not yet known quantum ground state and kinetic properties. In the long term, new emergent quantum and mesoscopic phenomena will be found that are not observed in bulk materials, only in such artificial structures. Understanding of the physics involved will be combined with the search for novel guiding principles for the next generation magnetic memory and, in the long term, enhancing the material and device functionalities via combining the specific properties of ferromagnets and superconductors.",SUPERCONDUCTIVITY - FERROMAGNETISM INTERPLAY in NANOSTRUCTURED HYBRID SYSTEMS,FP6,30 September 2007,01 April 2004,2112110.0 SHAPES,Atmel Roma Srl,information and communications technology,"There is no processing power ceiling for low consumption, low cost, dense DSP for future embedded human-centric applications treating audio, video, ultrasound and antenna signals. Nanoscale systems on chip will integrate billion-gate designs. The challenge is to find a scalable HW/SW design style for future CMOS technologies. The main problem is wiring, which threats Moore's law. Tiled architectures suggest a possible HW path: 'small' processing tiles connected by 'short wires'. The SW challenge is to provide a simple and efficient programming environment. SHAPES investigates a groundbreaking HW/SW architecture paradigm. The heterogeneous SHAPES tile is composed of a VLIW floating-point DSP, a RISC, on chip memory, and a network interface. For optimal balance among parallelism, local memory, and IP reuse on future technologies the tile gate count is limited to a few million gates. The SHAPES routing fabric connects on-chip and off-chip tiles, weaving a distributed packet switching network. 3D next-neighbors engineering methodologies will be studied for off-chip networking and maximum system density. For efficient programming, SHAPES will investigate a layered system software which does not destroy algorithmic and distribution info provided by the programmer and which is fully aware of the HW paradigm. For efficiency and QoS, the system SW manages intra-tile and inter-tile latencies, bandwidths, computing resources, using static and dynamic profiling. The SW accesses the on-chip and off-chip networks through a homogeneous interface. The same HW and SW interface is adopted for integration with signal acquisition and reconfigurable logic tiles. Generation after generation, the number of tiles on a single-chip will grow, but the application will be portable. SHAPES will set a new density record with multi-Teraops single-board computers and multi-Petaops systems exploited by an efficient programming environment.",Scalable software Hardware Architecture Platform for Embedded Systems,FP6,31 December 2009,31 December 2005,6297377.0 SHIELD,Vento NV,health,"The construction industry routinely experiences environments that demand excellent insulation performance -in terms of high humidity or applications demanding high fire resistance. These environments often present complex shapes and limited and difficult to reach space for such insulation materials. Whilst many insulation materials are available commercially, few combine a wide range of high level performance with a low price based on an excellent processability (spraying/injection). This project aims to address the market 'gap' of low-cost, fire-resistant, low-weight insulation materials coupled with excellent processability. It will develop a group of novel insulation materials which exhibit these desirable properties in industrial products by combining clay-nano-composites with supporting additives. The project will develop a suitable processing route for these clay-based insulation materials which minimises production cost by fully automating the spraying/injection production process. The project will develop and test first prototype applications. It will develop a high-performance insulation material offering a combination of: • low thermal conductivity (comparable to aerogel materials), • excellent fire resistance, • ease of processing (sprayable or injectable), • hydrophobicity (long term insulation stability in humid environments), • high durability • and low cost.","Development of a novel, low-cost fireproof Insulation Material",FP7,28 February 2015,01 March 2013,1194950.0 SHYMAN,University of Nottingham,health,"It is vital that nanomanufacturing routes facilitate an increase in production whilst being 'green', sustainable, low cost and capable of producing high quality materials. Continuous hydrothermal synthesis is an enabling and underpinning technology that is ready to prove itself at industrial scale as a result of recent breakthroughs in reactor design which suggest that it could now be scaled over 100 tons per annum. Academic specialists with international reputations in reactor modelling and kinetics and metrology will develop the 'know how' needed to scale up the current pilot scale system. Selected project partners with expertise in sustainability modelling and life cycle assessment will quantify the environmental impact and benefits of a process that uses water as a recyclable solvent, whilst producing the highest quality, dispersed and formulated products. In addition to scale up production, the process will be improved through case studies with industrial end users in four key areas -printed electronics with SOVY; surface coatings with CRF, PPG and SOVY; healthcare and medical with ENDOR and CERA; hybrid polymers and materials with TopGaN and REPSOL. Further value will be added to the Project by working on new materials that have been identified as key future targets but cannot be currently made, or made in significant quantities. The consortium is founded on the principle that the whole value chain (from nanoparticle production to final product) must be involved in the development of the technology. This will not only inform the development stages of the production process but also maximise 'market pull', rather than simply relying on subsequent 'technology push'.",Sustainable Hydrothermal Manufacturing of Nanomaterials,FP7,30 April 2016,01 May 2012,6863305.0 SI-BONE-POC,University Medicine of the Johannes Gutenberg-University Mainz * Universitätsmedizin der Johannes Gutenberg-Universität Mainz,health,"Silicatein is a unique enzyme from siliceous sponges that is able to catalyze the formation of an inorganic material, silica or 'biosilica' which forms the inorganic skeleton of these sponges. Another exceptional property of this protein is its dual function, as we discovered for the first time in the ERC Advanced Grant 'BIOSILICA' (Grant no. 268476): silicatein both (i) acts as an enzyme (biosilica formation) and (ii) exhibits structure-forming/guiding activity. Even more important with regard to the biomedical application of silicatein: the product of the enzymatic reaction, biosilica, is osteogenic and biocompatible and allows the formation of a moldable material -the ideal basis for the potential application in bone healing, as we found. Moreover, we demonstrated that biosilica not only increases the expression of bone morphogenic protein 2 (BMP-2), but also modulates the ratio of expression of two proteins, osteoprotegerin (OPG) and RANKL, that are crucial in pathogenesis of osteoporosis. Hence, biosilica has potential in prophylaxis and therapy of osteoporosis, a major health threat worldwide. Measures to prevent the development of osteoporosis have become increasingly important due to the demographic development in many industrialized countries. Our idea arising from the ERC-funded project is to apply the silica-enzymes fused to a hydroxyapatite-binding protein tag for the formation of bioactive biosilica-based scaffold / nanocomposite materials for bone regeneration and repair in osteoporotic patients and patients with related bone diseases. The proposed project aims at bringing this idea to a pre-demonstration stage by conducting a proof of concept and verifying its innovation potential. The potential commercialization opportunities and the IPR position of this idea will be clarified.",Silica-based Nanobiomedical Approaches for Treatment of Bone Diseases: Proof-of-Concept,FP7,31 December 2013,01 January 2013,149366.0 SIAM,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"SiAM aims at exploiting in future ICT devices and circuits the atomic nature of dopants used throughout microelectronics. The key idea is to use the very sharp, deep and reproducible potential created by a dopant in a semiconductor host crystal. Despite its small size (on the scale of the Bohr radius), the donor state of a single dopant can be addressed with conventional lithography techniques, and is therefore perfectly suitable for realistic devices exploiting the quantum nature of single atoms. The project relies on: - The extremely mature silicon technology in which, however, no quantum mechanical or atomic properties are at play when dopant atoms are used. - The very atomic nature of these dopants. The consortium will investigate dopants: - At the device level, with the demonstration of atomic devices (single dopant) and molecular devices (coupled dopants). A crucial effort towards integration of deterministic implantation in CMOS technology will be made. - In the theoretical understanding, for exploiting the specific features of dopant-based devices, especially time-dependent processes. - At the system level, with circuits exploiting the atomic characteristics of dopant based devices. The consortium brings together three methods for fabricating single-atom transistors: top-down silicon fabrication, bottom-up growth of nanowires and Scanning Tunneling Microscope (STM)-assisted fabrication. This is a unique combination of expertises only available in Europe. In addition, metrology and theory experts will exploit time-dependent phenomena in atomic devices for applications such as electron pumps. Another opportunity is to address directly the spin of a single dopant and make use of its extremely long coherence time to make a single atom quantum bit, crucial for applications in spintronics and quantum computation. Target outcomes: - Dopant-based devices: (i) atomically-precise dopant junctions realized with STM-assisted hydrogen resist lithography, (ii) single-atom transistors and pumps made in a silicon foundry and (iii) single atom spin quantum bit made in bottom-up silicon nanowires. - Time-dependent theory: the apparent limitation of non-adiabaticity will be turned into an advantage by exploiting the dynamical delays due to non-adiabaticity for robust single-gate operation. - Integration of the dopant-based CMOS devices in a circuit will be realized. STM-assisted lithography will be performed on silicon-on-insulator wafers with special surface preparation and capping, in order to avoid the usual surface preparation at very high temperature. Finally, the development of nanovias will pave the way for reintegration of STM defined donor device chips into a CMOS flowchart.",Silicon at the Atomic and Molecular scale,FP7,30 September 2016,01 October 2013,2040000.0 SIBESQ,University of Vienna * Universität Wien,photonics,"The scheme of coherent photon conversion (CPC) promises to break with a single device the two main conceptual roadblocks of scalable photonic quantum information processing: the scalable creation of single photons and the implementation of a deterministic photon-photon interaction. This could bring the vision of efficient and scalable optical quantum computing within reach of current technology. Such a future working quantum computer would revolutionize many fields of science and technology. After the first successful demonstration of a process suitable for CPC, published last year, the challenge is to reach sufficiently high effective nonlinearities. Silicon photonics, offers several distinct advantages for enhancing the effective nonlinearity making this possible. Also, it utilizes highly mature CMOS-fabrication technology with excellent design flexibility. The core research objective of the proposal is pioneering the design, fabrication and utilization of efficient CPC-devices based on integrated micro-cavities on a silicon-chip. The outgoing hosts Profs. Gaeta and Lipson at Cornell University (USA) have a world-leading expertise in fabricating and using novel silicon integrated-optics devices. In combination with the outstanding expertise of the return host Prof. Zeilinger at the University of Vienna (Austria) in photon-based quantum computing, this is ideal for the success of this proposal. There will be extensive micro-fabrication training at the renowned Cornell Nanofabrication Facility (CNF). Moreover, the broad complementary training program allows the fellow to reach an advanced level of professional maturity, enhanced by many international collaborations. The EU will gain direct access to a frontier technology: the design and fabrication of integrated (quantum) silicon-photonic devices. Besides the quantum information-based research (an EU priority under the FET-program), it also has an immense impact in telecommunication and on-chip signal processing.",Silicon-Chip Based Efficient and Scalable Quantum Processing and Production of Photons,FP7,31 July 2016,01 August 2013,272443.0 SICCATALYSIS,University of Burgundy * Université de Bourgogne,health,"Searching for the alternative energy sources and particularly for liquid fuel is strategic task for the nearest future. Renewable biomass, large deposits of natural gas and coal can be such sources. A major challenge for this direction is to develop efficient the gas-to-liquid process. The heart of such process is Fischer-Tropsch (FT) synthesis (CO hydrogenation by hydrogen) that takes place on Co or Fe catalysts supported on Al2O3 or SiO2. The FT reaction is usually carried out at 200 - 350 °C and at elevated pressures (up to 40 bars). At these stress conditions the chemical nature of the support material plays an important role. Significant support interaction is observed for Al2O3 and TiO2 leading to the formation of inactive compounds (so-called SMSI effect). SiO2 support exhibits a weaker interaction. However, its low thermal conductivity provokes overheating of the metals due to a high exothermic nature of the FT reaction. It leads to sintering of the active compounds. Consequently, these effects cause irreversible deactivation of the catalyst. The main objective of the proposed project is the development of new catalysts which demonstrate high activity/selectivity with improved stability towards extreme hydrothermal conditions in FT reaction. To do so, we propose to apply porous silicon carbide (pSiC) as a support in the catalyst. The use of pSiC prevents sintering and chemical reaction of cobalt metal with a support thanks to its high thermal conductivity, outstanding chemical inertness and mechanical strength. Moreover, silicon carbide demonstrates mesoporous framework enabling its impregnation with cobalt particles. This will lead to higher activity/selectivity in comparison to nonporous supports in terms of mass unit of the catalyst. For more benefit concepts of nanotechnology in catalyst preparation will be introduced to control the size and shape of cobalt nanoparticles, known as hot injection method.",Porous Silicon Carbide as a support for Co metal nanoparticles in Fischer–Tropsch synthesis,FP7,30 June 2014,01 July 2012,165300.0 SIGLAC,Leibniz Institute for Analytical Sciences * Leibniz-Institut für Analytische Wissenschaften eV (ISAS),manufacturing,"The goal of the project is the development of a novel analytical tools allowing in-vivo speciation of metal-protein complexes. The interest in this topic is driven by the fact that this information turns out to be crucial for the understanding of the molecular mechanisms of metal transport, chelation, and biotransformation which govern the bioavailibility of the metal and resistance of an organism to metals present in high concentrations in the environment. There is sufficient evidence in human for the carcinogenicity of cadmium and cadmium compounds; therefore the project is focused on the detection and characterization of proteins that are molecular targets for cadmium in model organisms such as Arabidopsis thaliana. The analytical tools are going to be based on two complementary approaches. In the first one, consisting of in vivo screening for a non-denaturating 2D gel electrophoresis, laser ablation ICP MS detection will be developed. In the alternative approach, a library of proteins of an organism will be created by the conventional (denaturating) 2D electrophoresis and made react with cadmium. For screening the library, electrophoresis on a chip coupled with ICP MS via a dedicated nanonebulizer will be developed for the high-throughput detection of the metal-protein complexes in the biological environment. Structural information of cadmium-protein will be obtain by use of molecular mass spectrometry MALDI-TOF (matrix assisted laser desoption ionization time-of flight) MS and ES (electrospray) MS/MS.",High throughput analytical screening for metal-protein complexes in the biological environment,FP6,31 October 2007,01 November 2005,157630.0 SIINN,Juelich Research Centre * Forschungszentrum Jülich,environment,"The primary aim of the SIINN ERA-NET is to promote the rapid transfer of the results of nanoscience and nanotechnology (N&N) research into industrial application by helping to create reliable conditions. In order to strengthen the European Research Area and to coordinate N&N-related R&D work, the project has the aim of bringing together a broad network of ministries, funding agencies, academic and industrial institutions to create a sustainable transnational programme of joint R&D in N&N.",Safe Implementation of Innovative Nanoscience and Nanotechnology,FP7,07 July 2017,08 January 2011,0.0 SILAMPS,University of Surrey,health,"This project is a six year programme of work to develop fully integrated optical emitters, lasers and optical amplifiers in silicon. Recent years have seen tremendous advances in the development of silicon photonic devices. However, the last hurdle to full silicon photonic systems and optical data transfer on and between integrated circuits are electrically pumped optical amplifiers and lasers in silicon using a CMOS compatible technology. Consequently, there have been massive efforts worldwide to search for efficient light emission from silicon. Our team made a major initial breakthrough producing the first LED in bulk silicon - published in NATURE (1997). Although a world first, this device only operated efficiently at low temperatures. This problem was solved using a new nanotechnology - dislocation engineering - reported in NATURE (2001) - and crucially uses only conventional CMOS technology. The development of this into a silicon injection laser and optical amplifiers is the essential next step for high technology high value applications. We have recently made a further breakthrough by obtaining extraordinary optical gain in erbium doped silicon that now offers a realistic route to this goal. Currently the incorporation of lasers and amplifiers on silicon platforms can only be achieved hybridizations of active devices based on III-V materials 'pasted' on to silicon waveguides and cavities. Gain has been reported using four-wave-mixing and Intel has recently demonstrated a Raman laser in silicon but both rely on purely optical-to-optical transitions and are fundamentally unable to be electrically pumped. We believe we have the only route that has the potential to produce electrically pumped amplifiers and lasers with room and higher temperature operation and that is capable of genuinely being fully integrated into silicon using standard silicon process technology.",Silicon integrated lasers and optical amplifiers,FP7,31 December 2014,01 January 2009,1928020.0 SILICON EUROPE,Silicon Saxony Management GmbH,information and communications technology,"Four of the leading European micro- and nanoelectronics regions are joining their research, development and production expertise to form the transnational, research-driven cluster “Silicon Europe”. Involved in this national “triple-helix” consortia are the following high-potential mature clusters: the German Silicon Saxony, centred in Dresden, the Dutch Point-One, centred around Eindhoven in the South Eastern part of the Netherlands, France’s Minalogic, centred in Grenoble, and Belgium’s DSP Valley, centred at Leuven.",Developing a leading-edge European Micro- and nanoelectronics cluster for energy efficient ICT,FP7,09 June 2017,10 January 2012,0.0 SILICON_LIGHT,Energieonderzoek Centrum Nederland * Energy Research Centre of the Netherlands,energy,"In this project we will increase the efficiency of thin-film silicon solar cells on flexible substrates by solving the issues linked to material quality, interface properties and light management, thus enabling lower production costs per Watt-peak. The general technological objectives of the project are the development of better materials and enhanced interfaces for thin film silicon solar cells, and to transfer the developed processes to an industrial production line. The most important project goals are: 1) Reduction of optical reflection and parasitic absorption losses: Design and industrial implementation of textured back contacts in flexible thin film silicon solar cells. 2) Reduction of recombination losses: Development and implementation of improved silicon absorber material. 3) Reduction of electric losses: Graded TCO layers which minimize the work function barrier between the p-layer and the TCO layer without loss of conductivity and transmission of the TCO. In addition, the top layer of the TCO stack should provide a good protection against moisture ingression. In order to achieve these objectives more in-depth knowledge is needed for several relevant key areas for thin film silicon solar cells. The main scientific objectives are: 1) Identification of the ideal texture for the back contact. This structure should maximize the light trapping in thin film silicon solar cells without deterioration of open-circuit voltage and fill factor. 2) Paradigm shift for the growth of microcrystalline silicon. In this project we want to show that it is possible to use microcrystalline silicon with high crystalline fractions leading to better current collection without voltage losses, and without crack formation when grown on nano-textured substrates. 3) Deeper understanding of moisture degradation mechanisms of common TCO's like ITO and AZO.",Improved material quality and light trapping in thin film silicon solar cells,FP7,31 December 2012,01 January 2010,5779519.0 SILICONSPIN,Chalmers University of Technology * Chalmers Tekniska Högskola,health,"Spintronics is the vision of using the spin of the electrons instead of its charge to perform information storage and processing. These spin based devices has the potential to make the future computers non-volatile, faster, with memory and processing integrated into a single chip, all with reduced energy consumption. A profound impact on the development of spintronics could come from exploiting spin degree of freedom in the main stream semiconductor like silicon at room temperature. The first goal of this proposal is to establish a physical understanding of the fundamental processes of efficient generation, sensitive detection, and effective manipulatipon of spin current in silicon. Spin polarization in silicon will be created by different methods such as - electrical spin injection, thermal spin injection, spin pumping, and spin Hall effect using ferromagnet/silicon heterostructures. Detection of the created spin polarization will be performed by combination of different techniques both in local and non-local geometry, for example by use of spin-valve measurements, Hanle measurements and inverse spin Hall effect measurements. Finally the manipulation of such spin polarization will be controlled by magnetic field and electric field. The aim of this proposal is to achieve all these operations in both n-type and p-type silicon at room temperature. The second goal is to implement silicon spintronic devices by integrating different functionalities obtained from our first goal. While relevant for the development of a spin based transistor, this work aims to go well beyond that, aiming for new routes to create and control spins in silicon nanostructures. For realization of this we propose to develop novel approaches for fabrication of silicon based nano-spintronic devices and design new transport measurement techniques which will lead to these fundamental physics experiments, and possibly new applications.",Spin Transport in Silicon Nanodevices,FP7,31 January 2016,01 February 2012,100000.0 SILINANO,Technical University of Munich * Technische Universität München,information and communications technology,"Silicene, the silicon analogue for graphene, has recently been discovered. It retains many of the interesting phenomena of graphene (2D geometry, strength, durability, the Dirac cone at the Fermi level), however it displays a significant buckling out of plane relating to the preference of silicon to form sp3, rather than sp2, hybridised bonds. This buckling is predicted to allow greater control over the electronic properties of silicene than has been traditionally been found in graphene, with silicene predicted to have a quantum spin Hall-effect and applications in valleytronics. Additionally, the use of silicon, rather than carbon, will allow silicene devices to be more readily integrated into current electronic technology.","Silicene, a new material for nanoelectronics",FP7,,,0.0 SILTRANS,SAV - Institute of Materials and Machine Mechanics * Ústav materiálov a mechaniky strojov,transport,"The SILTRANS project focuses on the development of novel composites consisting of percolating shaped bodies made from refractory metals (Nb, Mo, W) which are embedded in silicide-matrix. In such composites the silicide matrix provides excellent oxidation resistance at high temperature (forming silica), while percolating refractory metal reinforcements enhances their strength at high temperature, ductility and creep resistance. The continuous metallic skeleton serves as efficient tool against crack propagation, thus improving toughness of material at both high and low temperatures. The volume content of silicides will gradiently increase from the refractory core, forming continuous skin at the surface. The design of these tailored gradient materials (FGM) will be based on multiscale modelling, characterisation and non-destructive evaluation techniques developed to understand the role of residual stresses and acting degradation mechanisms. The infiltration technique for manufacturing of complex near-net shape parts having self-healing oxide coating will open a cost efficient way for wide range of structural applications in space, automotive and energy production sectors, especially when reliable performance at high temperature (above 1500 K) in oxidizing environment is required. The large involvement of industrial partners guarantees the rapid market uptake for developed materials.",Micro and Nanocrystalline Silicide - Refractory Metals FGM for Materials Innovation in Transport Applications,FP7,09 June 2015,10 January 2009,2997671.0 SILVERCROSS,Vivid Components Ltd.,transport,"Currently there are no suitable materials on the market that may be used for recording high quality full-colour holograms or holographic optical elements (HOEs). This lack of commercially-available material is crippling holographic-based industries, and consequently this remarkable technology is restricted to laboratories and research centres. Full colour holography is unquestionably the most perfect imaging technology known to science: the images it produces are almost indistinguishable from the original scene. Developments in other technology areas have created many applications for full-colour holograms and HOEs but these new market areas are unexploited due to this lack of a suitable recording material. This project aims to solve this problem by developing a new nanoparticle (5-10 nm), high sensitivity (<;2 mJ/cm2) low light-scattering, panchromatic silver halide emulsion which may be used for high quality imaging recording techniques, including full colour holograms and HOEs. A commercial product would allow the evolution of a whole new industry, which has a potential market size of several billion euros and could create up to 10,000 European jobs. The spheres of impact include security (through a virtually uncopiable imaging technology), 2-dimensional display systems (including LCD displays and head-up displays for aircraft and road vehicles), cultural heritage (perfect copies of exhibits from galleries and museums could be displayed at any location), art and portraiture, advertising and in the future 3-dimensional holographic dynamic imaging systems (i.e. 3D-TV). This project will: * Develop and verify nanoparticle (5-10 nm) panchromatic, isochromatic silver halide emulsions with high sensitivity (< 2 mJ/cm2) * Identify a process of coating these emulsions onto glass plates * Verify the performance and storage characteristics of this recording material * Develop a prototype manufacturing apparatus and process for this recording material",Mass production of silver halide recording material for full colour holographic applications,FP6,27 February 2007,29 November 2004,918344.0 SIM-MMT,Royal Institute of Technology * Kungliga Tekniska Högskolan,health,"The demand for micromachining is currently increasing with the reduced device dimensions in medical, electronics, aerospace and defense fields. As nanotechnology advances in leaps and bounds, the mechanical interface of these devices becomes more critical. Unfortunately, the techniques of micromachining have not been able to keep up with the advances in nanotechnology. This disparity between the two provides an opportunity for research. To bridge this gap, new techniques in micromachining need to be created Machine choice is a critical step in the micromachining. The rigidity of the machine tool is important as the small vibrations are amplified relative to the smaller tool diameter (e.g. vibration of 0.001 mm is a much larger fraction (1%) of a 0.10 mm end mill) and reduce the precision and damage tools In contrast to large machine tools, meso-scale machine tools (MMT) are apt due to their small footprint, reduced energy consumption and less cost. However, the manufacture of MMT is at its nascent stage. The existing approaches considers the dynamics of machine tool subsystems individually, which can not represent the performance of machine tool in operation Hence, in this work, a generic framework is proposed for building of high performance MMTs based on coupled simulation approach that consider the dynamics of - integrated MMT, controller and machining process, without building the prototype. This approach will reduce time and cost of manufacture and increases the performance of machining The model of the existing MMT is developed by including the model of proposed novel dampers and the performance will be improved by coupled dynamics simulations. This approach is validated by physically modifying the existing design of MMT with suggested changes by simulations. From the gained knowledge, a generic framework will be developed for building of MMT and will be demonstrated The training activities include development of technical (multibody dynamics, machine tool d",Novel miniature machine tool design and realization for next generation high performance micro-components: A coupled-dynamic modelling and simulation approach,FP7,08 December 2013,09 December 2011,185964.0 SIMAG,Consejo Superior De Investigaciones Científicas (CSIC),information and communications technology,"The framework of this project is the research on nanostructures for magnetoelectronic devices. For the development of semiconductor spin-electronics (spintronics), it is important to find out materials exhibiting ferromagnetic behavior at room temperature, high spin polarization at the Fermi level, and which are structurally compatible with the semiconductor platforms used in the electronic industry. Heusler intermetallic alloys represent a promising set of compounds because most of them are ferromagnetic, with attractively high Curie temperatures, exhibit high spin polarization, and offer tailoring possibilities as magnetic materials similar to the tailoring possibilities of compound semiconductors as electronic materials. Diluted ferromagnetic semiconductors are also materials of high interest in spintronics because of their optimal compatibility with semiconductor platforms, such that they are ideal candidates as sources for spin injection. The project focuses on the MBE synthesis and analysis of thin films of these two types of materials.Thin films of full Heusler alloys of the type X2YZ with X=Co, Fe, Y=Mn, and Z=Si, Ge will be deposited on Si substrates. Major challenges are achieving good film quality despite the lattice mismatch, controlling the composition, atomic ordering, and defects, both in the film itself and at interfaces. The structural, electronic, magnetic, and transport properties of the films will be investigated, and compared with theoretical predictions.Si (Ge) layers incorporating transition metal elements (Mn, Cr, Co, Fe) at high concentrations will be epitaxially grown on Si (Ge) substrates. Specific growth conditions will be searched to avoid phase separation. The intrinsic properties of the layers will be analyzed in order to determine the applicability in spintronic devices, and for a general understanding of the mechanism of ferromagnetism in diluted magnetic semiconductors.",Ferromagnetic-semiconductor hybrid nanostructures for Si-based spintronics: Synthesis and properties,FP6,31 December 2005,01 January 2005,40000.0 SIMBA,Braunschweig University of Technology * Technische Universität Braunschweig,health,"In order to advance single-molecule fluorescence spectroscopy to the next level, handling and analysis of single molecules has to become broadly available. A further quantum leap is required to proceed to commercially successful applications such as drug screening and medical diagnostics. In this project, I suggest a strategy to overcome the fundamental gap between the nanomolar concentration regime of current optical single-molecule spectroscopy and the nano- to millimolar dissociation constants of typical biomolecular interactions. I will use nano-apertures, which confine the detection to sub-attoliter volumes and allow single-molecule studies at elevated concentrations. To overcome unspecific binding and deteriorated fluorescence signals in the nano-apertures, I will use tailor-made DNA nanostructures produced by DNA origami. These nanostructures will match the nano-apertures like a plug in a socket. Inserting molecules at programmed positions in the nanostructures will open up a new realm of applications by the ability to immobilize exactly one molecule per nano-aperture and by obtaining comparable signals from every nano-aperture. I will spectroscopically characterize the nano-apertures creating a fluorescence map of their inside. I will exemplarily use the new abilities for previously impossible applications such as several folds improvement of single-molecule DNA sequencing, direct single-molecule RNA sequencing by reverse transcriptase for cancer screening, for paralleled drug screening of HIV protease inhibitors and for studying the chemomechanical coupling of single helicases. In summary, I envision a broadly applicable platform that has the potential to become a golden standard by enabling both ground breaking fundamental research and commercial applications.",Single-Molecule BioAssays at Elevated Concentrations,FP7,31 October 2015,01 November 2010,1456374.0 SIMONE,Chalmers University of Technology * Chalmers Tekniska Högskola,photonics,"The development of micro fabrication and field effect transistors are key enabling technologies for todays information society. It is hard to imagine superfast and omnipresent electronic devices, information technology, the Internet and mobile communication technologies without access to continuously cheaper and miniaturized microprocessors. The giant leaps in performance of microprocessors from the first personal computing machines to todays mobile devices are to a large extent realized via miniaturization of the active components. The ultimate limit of miniaturization of electronic components is the realization of single molecule electronics. Due to fundamental physical limitations, single molecule resolution cannot be achieved using classical top-down lithographic techniques. At the same time, existing surface functionalization schemes do not provide any means of placing a single molecule with high precision at a specific location on a nanostructure. This project has the ambitious goal of establishing the first method ever allowing for self-assembly of multiple single molecule devices in a parallel way and thereby provide the first method ever allowing for multiple individual single molecule components to operate together in the same device. The impact of the technology platforms described herein goes vastly beyond the field of single molecule electronics and utilization in ultra-sensitive plasmonic biosensors with a digital single molecule response will be explored in parallel with the main roadmaps of the project.",Single Molecule Nano Electronics (SIMONE),FP7,31 January 2019,01 February 2014,1500000.0 SIMS,"University of the West of England, Bristol",environment,"The widespread availability of smart miniaturised systems is limited by the inability to integrate a sufficient number of functionalities into a single device at low cost and high volume using traditional production technologies. Organic, flexible and printed electronics (OFPE) offers this possibility. However, it too must overcome some significant challenges relating to device interfacing and fabrication. Key among these is the availability of subsystems (sensors, displays, power and circuitry) suitable for integration through OFPE, as well as the ability to combine these components through compatible processes.","Development of a Smart Integrated Miniaturised Sensor System for analytical challenges in diagnostics, industry and the environment",FP7,02 April 2016,09 January 2010,0.0 SIMTECH,University of Bordeaux * Université de Bordeaux,photonics,"This project is devoted to the new trends in superconductivity. It contains both experimental and theoretical component. We intend to realize the new superconductive nano-systems with high critical parameters, to study the possibility of superconductivity in the system of relativistic electrons in graphene, pumping effect in Josephson systems, a new mechanism of interaction between electrons of two Fermi seas, mediated by excitations of a Bose-Einstein condensate of exciton-polaritons, to develop a new diagnostic methods based on the fluctuation spectroscopy, to apply them for investigation of the pseudo-gap state properties of HTS. In the present project the experts in superconductivity of the highest international recognition take part side by side with young researchers from five institutions of four countries. The network institutions are located in the EU countries (France, Italy) and in the Eligible Third Countries of the former Soviet Union (Russia, Ukraine). Each of them has its own specialization and is related with others by virtue of already existing traditional collaborative links, partially supported by different national or bilateral programs. In the course of the project we are going to exploit the existing collaboration links and to create the new ones between partners. The main goal of the project is studying and optimization of the mechanisms of realization of the superconductivity in novel systems and materials. Series of bilateral visits, training workshops and meetings are planned for this purpose.","New Century of Superconductivity: Ideas, Materials, Technologies",FP7,31 October 2014,01 November 2010,712800.0 SINANO,France Innovation Scientifique et Transfert (FIST),information and communications technology,"SINANO aims to strengthen European scientific and technological excellence in the field of electronic,Si-based nanodevices for terascale integrated circuits. Over the next quarter century considerablechallenges exist to push the limits of silicon integration down to nanometric dimensions. These can bestbe addressed by integration, at the European level, of the individually excellent research capabilitiesalready existing in the main university and national research centers. SINANO's activities, with long-term and multidisciplinary objectives, could herald a revolution in 1C technology, involving integrationof nanoscale CMOS and emerging post-CMOS logic and memory devices. SINANO will work toenhance device performance and integration, to meet the ever increasing demands of communicationsand computing. The network includes partners with expertise required to develop these advanceddevices, from basic materials science through design and fabrication to characterisation and devicemodelling. This ambitious programme will make Europe the world-leading center for nanoelectronicdevices - from fundamentals through to realisation, advancing this crucial technology to underpin theEuropean economy over the coming decades.The proposed Joint Programme of Activities includes significant integrating activities: coordination ofthe partners' activities leading to the extension of specialisation, a joint technical research programme,sharing Joint Research Platforms for Processing and Characterisation, management of knowledge, staffexchanges, electronic communication (e-mail, conferencing, website), activities to spread excellence(training researchers, students and technical staff, dissemination of results by open EuropeanWorkshops). It will be orchestrated by a unified management structure comprising a Governing Board,Executive and Scientific Committee consisting of WP leaders and representatives of the main industrial partners, and WP leaders.",Silicon-based Nanodevices,FP6,28 February 2007,28 December 2003,9900000.0 SINANOTUNE,University of Aveiro * Universidade de Aveiro,energy,"Silicon nanostructured films are promising materials for photovoltaic applications. By exploring confinement effects and changing the surface morphology, it is possible to vary the optical absorption threshold energy without the resource to different semiconductors. However, to exploit the potential of this class of materials, it is necessary to achieve a detailed understanding and control of n- and p-type doping. Here, a study of the interaction of dopant atoms with the surface of stand-alone silicon clusters is proposed. The investigation will be carried out using density functional theory electronic structure calculations, and observable properties will be applied to the interpretation of experimental results. The aim is to find the combination of dopant species, surface passivation and post-processing treatments that leads to optimum n- and p-type doping efficiency.",Dopant-surface interactions in silicon nanoclusters,FP7,31 December 2012,01 January 2011,148283.0 SINAPS,University College Cork,health,"The aim of the SiNAPS project is to develop standalone 'dust'-sized chemical sensing platforms that harvest energy from ambient electromagnetic radiation (light) and will enable miniaturisation below the current mm^3 barrier. Current solutions in nanoelectronics are enabled by new materials at the nanoscale. It is proposed to use high-density semiconductor nanowire arrays, such as Si and Ge, as efficient photovoltaic units and low-power chemical sensing elements on small volume modules to be integrated, via 3D system in a chip, in a miniaturised platform that transmits the acquired information wirelessly for further processing. To demonstrate the proof-of-concept without committing huge resources in optimization the SiNAPS project has set a pragmatic but ambitious, miniaturisation target ~10^8 µm^3, beyond the state-of-the-art. With further development of the energy harvesting and sensing technology, 10^6 µm^3 and below can be possible. SiNAPS brings together a consortium to address the two topics of the ICT-Proactive call, namely: (a) fundamentals of ambient energy harvesting at the nanoscale and (b) development of self powered autonomous sensor devices, with target dimensions of 1 mm^3. These topics are of great interest in the areas of energy supply, energy use in ICT, smart(er) buildings, medical diagnostics, e-health and integrated smart systems. SiNAPS involves the development of the capacity of nanowires for use as a nanoscale energy harvester and a (bio-)chemical sensor for the prototype biotin-streptavidin system via fundamental studies. Miniaturised CMOS electronics will be developed for efficient power management and sensor interface. Existing IP for wireless communication will be used to avoid costly development. The integrated modules will be used to demonstrate the SiNAPS mote concept. Concluding SiNAPS, a set of new technologies for self powered autonomous devices and beyond will be available for further development towards commercialisation.",Semiconducting Nanowire Platform for Autonomous Sensors,FP7,31 October 2013,01 August 2010,2369999.0 SINERGY,Consejo Superior De Investigaciones Científicas (CSIC),energy,"This proposal selects a series of relevant examples of power microgeneration and storage (thermoelectric generators, vibrational harvesters and microstructrured batteries) and pushes them further into their development and performance maturity. With that goal in mind the emphasis is put on the materials themselves and their integration route into a technology able to bring the eventual solutions closer to an exploitable phase. For this reason we consider novel silicon technology compatible materials as our starting point. The combination of those materials with device-making silicon micro and nanotechnologies is especially well positioned to make breakthrough developments in the microdomain regarding energy harvesting and storage. This approach enables (a) nanostructuration of the materials themselves, (b) dense device architectures by means of 3D high aspect ratio microstructures -which increase the resulting energy density, and (c) open the path for miniaturized complete systems through the compact assembly of the different elements involved (e.g. harvesters, batteries, power control electronics, devices to be powered) by means of hybrid or monolithic integration strategies. Wafer level processes will be favored to assure an easier transferability of the results to a fabrication stage. The high density architectures and system manufacturability provided by silicon micro and nanotechnologies endorse the use of silicon friendly materials even when their intrinsic properties may lag behind other technologically exotic material alternatives. Two application scenarios, engine/machinery fault prevention and tire pressure monitoring systems, relying on self-powered wireless sensor networks, have been chosen as frame of reference for our microenergy developments since they offer different harvesting opportunities (vibrations and waste heat) and realistic and long term scenarios to work on.",SILICON FRIENDLY MATERIALS AND DEVICE SOLUTIONS FOR MICROENERGY APPLICATIONS,FP7,31 October 2016,01 November 2013,3794913.0 SINGLE ATOM CONTROL,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),information and communications technology,"Manipulation of single atoms and ions is a rapidly developping field. It has shown implications for quantum information processing that directly utilizes quantum mechanics to encode, process and store information onto single ions, single atoms and single photons. In particular, neutral atoms are promising candidates for quantum information processing, as they are believed to be scalable using large optical architecture. The two objectives of this proposal aim at implementing the steps necessary to prove the individually addressed neutral atoms as suitable candidates for quantum information processing. The first objective will demonstrate the deterministic loading of single atoms into the ground state of tight optical tweezers. This will be achieved by producing a Bose-Einstein rubidium atom condensate in a cross dipole trap using diode lasers - a challenging but significant result. We will then superimpose onto the condensate a tightly focused optical tweezer, which we will adiabatically turn on to deterministically trap one atom in the vibrational ground state of the optical tweezer. The second objective is to implement the controlled collision between two trapped atoms. It will be achieved by starting with two atoms trapped in two optical tweezers, where one tweezer is able to move with respect to the other. Bringing the tweezers into contact allows the atoms to interact in the controlled way as they accumulate a phase shift due to their interaction energy. This type of interaction is a first step towards showing a quantum phase gate - one of the few elementary gates required to perform quantum computations. The project will take place in Orsay, in the Quantum Optics Group of the Institut d'Optique, who already developped a strong expertise in trapping single atoms. This work will be part of new long-term collaboration between the Orsay group and the Australian National University.",Deterministic loading of single atoms in optical tweezers and controlled collision,FP6,31 December 2008,01 January 2007,151938.36 SINGLE-MOLEC-SWITCH,University of Barcelona * Universitat de Barcelona,information and communications technology,"Today, one of the central themes in the Nanoscience is Molecular Electronics which relies on the ability to measure and control electrical current through molecular scaffolds. As in the case of conventional semiconductor electronics that took several decades of research to reach commercial applications, the concept of using few molecules or even a single molecule as active components in electronic devices is now closer to reality. Molecular Electronics research continues in deepening our understanding of the properties of single molecules and is anticipated to lead to novel organic (opto)-electronic devices. However, the question remains “when will this fundamental science turn into a commercial technology?” The answer for this question is “soon”. However, this field is still in its infancy and there are several unsolved issues, the most critical one being optimizing molecular contacts with electrodes and controlling current flow through molecular junctions.",Developing single-molecule switches for applications in nanoscale organic devices,FP7,10 February 2016,10 March 2014,0.0 SINGLECELLDYNAMICS,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),health,"Immune cells constantly receive signalling inputs such as pathogen-emitted molecules, use gene regulatory pathways to process these signals, and generate outputs by secreting signalling molecules like cytokines. Characterizing the input-output relationship of a biological system helps understanding its regulatory mechanisms, and allows building models to predict how the system will operate in complex physiological scenarios, such as population tissue response to infection. A major obstacle in this endeavor has been the so-called 'biological noise', or significant variability in measured molecular parameters between cells. Such variability makes time-dependent single-cell analysis crucial to understand how biological systems operate. Development of new analytical tools with improved functionality, accuracy, and throughput is needed to realize the full potential of single-cell analysis. We propose to develop automated, high-throughput, Optofluidic single-cell analysis systems with unprecedented capabilities, and to use them in understanding how immune cells organize in tissue during response to infection. Microfluidic membrane-valves, nanodroplets, optics, and automation will be integrated to achieve an unparalleled degree of control over single immune cells. Multi-functional lab-on-chip devices will simultaneously measure: a) The activity of immune regulatory proteins such as NF-κB, and b) Inflammatory cytokines secreted from single immune cells in a time-dependent manner, under precisely defined biochemical inputs. Characterizing macrophage cytokine secretion dynamics under combinatorial regiments of bacterial and apoptotic-cell signals will allow dissecting the signalling mechanism responsible from the resolution of inflammation. We will identify the role of the NF-κB pathway in regulation of cytokine dynamics. We will use our data to develop a computer model of tissue-level immune response to pathogens through the NF-κB pathway and cytokine signaling.",Optofluidic toolkit for characterizing single-cell dynamics in systems immunology,FP7,30 September 2018,01 October 2013,1499165.0 SINGLEION,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The progress in optical spectroscopy has made it is possible to study individual quantum emitters. However, only a few select 'bright' emitters have been detected so far, leaving a large gap in the choice of critical parameters such as wavelength, coherence time, and energy level schemes. In this project, we develop methods for the detection of single emitters with long fluorescence lifetimes. In particular, we concentrate on rare earth ions embedded in crystals, which are of great technological and fundamental interest. To achieve this goal, we exploit methods from ultrahigh resolution microscopy, laser spectroscopy, scanning probe technology, cavity quantum electrodynamics, and plasmonics. The first approach to the detection of single ions at cryogenic temperatures will be to perform direct fluorescence excitation as well as absorption spectroscopy to address single Pr3+ ions spectrally within the inhomogeneous line of the sample. Here, we will develop a tunable laser system with sub-kHz linewidth for probing the narrow transitions of the ions. We expect a signal-to-noise ratio of about 10 in this first step. In order to improve this, we will enhance the emission of ions by pursuing two strategies. In the first case, we shall embed doped crystalline films in monolithic Bragg microcavities. In the second approach, we use plasmonic nanoantennas to reduce the radiative lifetime of the ions in the near field. The well-defined energy levels of ions provide ways for the preparation of long-lived coherent states for use in quantum information processing. Furthermore, access to the homogeneous spectra of ions at different temperatures and doping concentrations will shed light on fundamental open questions regarding their interaction with their matrices.",Spectroscopy and microscopy of single ions in the solid state,FP7,31 July 2016,01 August 2011,1925673.0 SINGLEMOTOR-FLIN,Vereniging voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek en Patientenzorg * Association for Christian Higher Education Scientific Research and Patient Care,health,"The recently invented fluorescence lifetime imaging nanoscopy (FLIN) provides a groundbreaking tool for the study of single molecules (SM) and single molecular motors (SMM) as well as a broad array of phenomena in the NanoWorld. Previous limitations for SMM studies, resolution, short observation times, and photo-dynamic reactions, are now overcome by minimal-invasive picosecond FLIN. FLIN is the extension of the extremely successful fluorescence lifetime imaging microscopy (FLIM) into the nano-domain, with 10 to 100 nm space resolution. FLIN results from the combination of 4pi-microscopy with novel ultrasensitive, nonscanning imaging detectors, based on time- and space-correlated single photon counting (TSCSPC) that allows ultra-low excitation levels. This results in long-period (#gt; 1 hour), minimal-invasive observation of living cells and SM/SMM, without any cell damage or irreversible bleaching. Minimal-invasive FLIN (MI-FLIN) with global point spread function modelling allows observation of SMM movement at 1-nm accuracy and 10-nm resolution. Parallel to (i) MI-FLIN/FLIM implementation, the consortium will (ii) improve sensitivity, time- and space-resolution as well as throughput of the TSCSPC detectors, (iii) explore an array of novel applications provided by MI-FLIM/FLIN, such as nanometer SMM-tracking, (iv) develop a super-background-free TIRF microscope to improve detectability of SM/SMM, and (v) examine the behaviour of four different types of SMM and their dependence on energy-input. Enhanced basic understanding of biological and artificial machines and motors will lead to improved model systems and proceed one day to the design of artificial systems, improving the interface of biological and non-biological worlds. Furthermore, biological SMM are involved in many disease states such as Alzheimers, Werner syndrome and infectious diseases. Our studies aim to improve understanding of how these motors operate and how they break down in disease.",Long-Period Observation of Single (Bio)-Molecular Motors by Minimal-Invasive Fluorescence Lifetime Imaging Nanoscopy (FLIN),FP6,30 November 2008,01 June 2005,1660000.0 SINGLEREPLISOME,Rijksuniversiteit Groningen * University of Groningen,health,"The study of biological processes at the single-molecule level has greatly influenced our view of the molecular mechanisms that define life. However, studies so far have mainly focused on individual, purified proteins in non-physiological environments. Since cellular processes are typically not mediated by single proteins, but rather by large complexes of dynamically interacting components, the development of the tools to study such large complexes with single-molecule sensitivity is an important direction. With our initial successes in developing the single-molecule tools to study DNA replication, we have begun to open the field of single-molecule biophysics to the study of large, multi-component complexes. Here we describe how we will develop new single-molecule approaches to study the physical interactions and molecular mechanisms that control the DNA replication machinery, both in simple model systems and in higher organisms. By measuring the elastic properties of DNA and simultaneously visualizing fluorescently labeled replication proteins acting on the same DNA we will be able to relate the physical structure and composition of the replication complex to its mechanism of action. We will also develop the tools to study the replication machinery in cellular extracts of higher organisms; an environment that is compatible with our nanomanipulation and fluorescence tools, but faithfully mimics the complex environment in which these processes normally take place. Our objective is to arrive at a complete molecular understanding of how DNA replication works. We will use the tools described in this proposal to address a number of poorly understood issues: What is the mechanism of coupling between DNA unwinding and synthesis? How are the two DNA polymerases coordinated? How does replication deal with roadblocks on the DNA? Our approach to obtain 'molecular movies' of the replication process represents an entirely novel strategy to understand these issues.",Under the hood: Single-molecule studies of the DNA replication machinery,FP7,31 January 2017,01 February 2012,2000000.0 SINGLESENS,Johannes Gutenberg University of Mainz * Johannes Gutenberg-Universität Mainz,health,"Optical spectroscopy of single plasmonic nanoparticles (NPs) has evolved into a recognized tool for nanoscopic sensing applications, using the sensitivity to the NP's environment,charge, size, shape, and proximity to other NPs. Here, I propose taking advantage of the nanoparticle s minuscule size approaching molecular dimensions in novel ways. Single particle plasmon sensors are in many ways the smallest possible giving unprecedented access to molecular events. The small size amplifies fluctuations by molecular events, allows massive parallel detection of analytes within tiny devices, and to monitor single nanoparticle formation and electrochemical surface reactions in real time. The objective of this project is therefore to develop and explore single-particle plasmon spectroscopy as a novel tool to study such molecular processes. The objective will be reached by (1) building three new setups progressing far beyond current technology and increasing time resolution, spectral sensitivity, and parallelization capability many orders of magnitude, (2) synthesizing nanoparticles with optimal plasmon sensing properties, and (3) simulating plasmon properties to guide the experiments and understand the physics behind the observed phenomena. The single-particle plasmon spectroscopy technique will be applied in four scientific directions to demonstrate its potential: (4) analyzing distance fluctuations of particle pairs linked by (bio-)polymers, (5) recording coverage fluctuations of biomolecules bound to nanoparticles, (6) demonstrating parallel detection of many analytes in multiplexed microfluidic devices, and (7) following particle formation and chemical reactions in a single particle reactor . Single-particle plasmon spectroscopy has the potential to provide a revolutionary new tool to study molecular processes and to become a major commercial analytical tool, especially for pharmaceutical research and development.",Single metal nanoparticles as molecular sensors,FP7,31 December 2015,01 January 2011,1510000.0 SINOXYGEN,University of Crete * Panepistimio Kritis,health,"Novel synthetic methods are vital to the work of a host of key chemical disciplines; from new materials and nanotechnology to pharmaceuticals, practitioners constantly need cleaner, greener, milder and more efficient ways to synthesize their chosen targets. In this proposal, we seek to develop, and then apply to some very challenging scenarios, a set of particularly powerful and beyond the state-of-the-art new methods, using singlet oxygen, that will meet all these tough criteria. Singlet oxygen is a remarkable reagent; it is a natural, cheap, green and atom-efficient oxidant. It also makes an ideal initiator for cascade reaction sequences through which molecular complexity is enhanced very rapidly and effectively. With this chemistry protecting groups and toxic heavy metal oxidants, both normally associated with the construction of molecules rich in oxygen functionality, are not needed. In the projects described within this proposal, singlet oxygen will be manipulated to orchestrate a diverse range of cascade reaction sequences, and 'super cascade' reaction sequences, by which complex polyoxygenated and polycyclic molecular architectures will be synthesized, from very simple and readily accessible furan precursors, in one-pot. Polyoxygenated-polycyclic motifs are common synthetic targets across a range of disciplines. In our case, we will focus research efforts towards bioactive natural products because these highly complex and intricate structures provide the best, and most challenging, testing grounds for any new set of chemical methods. The natural products chosen belong to the azaspiracid, pinnatoxin/pteriatoxin, spirolide and pectentoxin families, respectively. We also hope to further promote the widespread application of these singlet oxygen-based chemical solutions to a host of problems by developing a prototype Continuous Flow Reactor that will facilitate large scale photooxygenations.",Advancing the Green Chemistry of Singlet Oxygen and Applying it to Synthetic Challenges,FP7,30 September 2016,01 October 2011,1338000.0 SINPHONIA,Technische Universiteit Eindhoven * Eindhoven University of Technology,photonics,"This project targets the development of near-infrared single-photon optical detectors based on nanostructured superconductors. These detectors will achieve ultimate sensitivity and temporal resolution for application in long-distance optical communications, quantum cryptography, diagnostics and testing, and remote sensing. We will pursue the following objectives: - Fabricate single-photon optical detectors with unprecedented performance at telecom wavelengths (four orders of magnitude more sensitive and three orders of magnitude faster than commercially-available avalanche photodiodes and photomultipliers) - Demonstrate their implementation in several IST applications by industrial partners In order to achieve these goals, the following approach will be taken: - Material development, nanofabrication and optical characterisation will be pursued by academic and public research institutions - Applications will be demonstrated by SMEs and major industrial players with a leading position in optical communications, professional electronics and advanced optical technologies. The project will make an impact on European competitiveness by: - Advancing the state-of-the-art in strategic nanomaterials - Providing the European industrial and scientific community with a tool whose performance will open new opportunities for industrial use and fundamental science - Facilitating the industrial take-up of a nanophotonic technology by spanning the value chain from devices to applications.",Single-photon nanostructured detectors for advanced optical applications,FP6,31 March 2009,01 January 2006,1916856.0 SINPLEX,German Aerospace Center * Deutsches Zentrum für Luft-und Raumfahrt,transport,"The main goal of the SINPLEX project is to develop an innovative solution in order to reduce significantly the mass of the navigation subsystem for exploration missions which include a landing and/or a rendezvous and capture or docking phase. It is a contribution to the strengthening of the European position for space exploration. It targets increasing the scientific return of exploration missions, enabling new types of missions and targets, and reducing launch cost and travel time.",Small Integrated Navigator for PLanetary EXploration,FP7,12 July 2015,01 January 2012,0.0 SISPIN,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),information and communications technology,"Quantum spintronics aims at utilizing the quantum nature of individual spins to bring new functionalities into logic circuits, either to make classical information processing more efficient or to implement spin-based quantum algorithms. Two critical aspects for quantum spintronics are a long spin coherence time and a strong, tunable spin-orbit interaction for fast electrical manipulation of spins. Up to now, experiments have mainly focused on III-V semiconductor nanostructures, where hyperfine coupling with nuclear spins limits electron-spin coherence. Low nuclear spin materials, and in particular group-IV semiconductors, were found to be a natural alternative. However, in most of the currently studied group-IV based systems, spin-orbit coupling is very weak, preventing fast electrical manipulation of spins.",Silicon Platform for Quantum Spintronics,FP7,08 July 2018,09 January 2013,0.0 SISQ,Universiteit Twente * Twente University,information and communications technology,"The objective is realising the first silicon single-electron spin quantum bits, which will be a significant step towards the realization of the first generation quantum computers. Quantum computers are expected to dramatically outperform the largest classical supercomputers in solving specific important problems. Applications involve data encryption (for intrinsically secure communication), the efficient simulation of quantum systems (such as chemical reactions), and support in many emerging forms of artificial nanotechnology, and in our understanding of the nanomachinery of biological molecules.",Silicon Spin Quantum Bits,FP7,07 July 2017,08 January 2011,0.0 SKIN TREAT,Ahava Dead Sea Laboratories Ltd.,health,"Economical and health interests of skin problems are fast growing issues in Europe, following the remarkable extension in life expectancy in western countries, together with the increased awareness of UV radiation risks. Personalized health care approach has been discussed over the past few years and had been accompanied by developing innovative technologies capable of identifying specific biomarkers, supporting a personalized diagnosis and treatments, especially concerning bio-compatibility of drugs. Skin Treat intends to develop and validate nano-chemical and bio- technologies to achieve an accurate matching of drugs, and drug delivery vehicles, to skin diseases and sub pathogenic skin conditions in their individual context. The project will design novel generation of pharmaceutical products, as well as consumer personalized service, in order to fit customers' tailored needs with a support of strategic consortium based on partnership among SMEs and research organizations. The development of personalized skin therapy protocols requires achieving an accurate diagnostics of skin condition and an extensive analysis of biological markers. Non invasive methods as well as minimal invasive skin sampling, will support the establishment of a range of biological profiles corresponding to skin diseases and skin sub pathologic conditions. Statistical processing of these data will allow defining biomarkers patterns specifically associated with given clinical conditions. A bio-informatics data mining protocol will be elaborated, together with multifunctional biomarker analysis software, to build a refined, personalized diagnosis method. Finally, the computer data analysis will yield a decision support system (DSS) to assist dermatologists, chemist and clients for prescription of personalized treatment. Skin Treat concept will be evaluated by a wet pilot study of the whole ervice chain on a few, selected skin disorders like psoriasis, contact dermatitis, and UV skin photo-aging damages.",Novel approaches for the development of customized skin treatments and services (Test case: Dead Sea Minerals and Conventional drugs),FP7,31 August 2012,01 September 2008,3950035.0 SKYHIGH,University of Leeds,information and communications technology,"Skyrmions are particle-like solutions of nonlinear equations that are now found in many physical contexts, such as Bose-Einstein condensates, the quantum Hall effect, and liquid crystals. Chrial magnetic skyrmions have recently been discovered, manifesting themselves as whirling spin structures including all possible spin directions. These novel spin textures are now being studied in earnest due to their prospects for applications in data storage.",Skyrmion devices and their high frequency dynamics,FP7,03 July 2018,04 January 2014,0.0 SLIC,Ayanda Biosystems SA,health,"Molecular diagnostics of microbial pathogens is an integral part of modern medicine. The growing need for direct genotyping and/or the screening of the transcriptome calls for the development of alternative technologies. The STREP consortium plans to develop a cost-effective platform for the identification bacterial species based on the SLIC-Nanobiosystem. Using tmRNA transcripts of the bacterial ssrA gene, we will be able to detect, quantify and identify bacterial species in a single homogenous assay format. The SLIC-Nanobiosystem consists of a self-assembled lipid bilayer membrane that integrates a synthetic ligand-gated ion channel (SLIC). The SLIC comprises a capture molecule that can specifically bind a given analyte, a process that is monitored via electrical impedance spectroscopy. With this system the effect from even a few channels can be resolved thus providing an ultra-sensitive, highly stable and versatile biosensor platform. We intend to employ transcripts (tmRNA) of the ssrA gene in order to identify bacterial species present in clinical samples. These transcripts occur in high abundance and contain a core sequence that is species specific, a feature which will be exploited to identify infectious disease pathogens. Identification of the different bacterial tmRNA transcripts will be accomplished by displaying a library of nucleic acid capture probes on the SLIC. This will enable species identification and discrimination between one or more species present in the sample if mixed species infection is present. Since the detection equipment will be based on electronics, the realization of miniaturized/compact and cost-effective instruments will be possible. Our approach will lay the foundation for a new generation of multiparametric molecular testing systems, that will open novel opportunities within the area of point-of-care applications in the clinical diagnostics market.",SLIC-Biosensors in Molecular Diagnostics: Nanotechnology for the Analysis of species-specific Microbial Transcripts,FP6,31 December 2007,01 January 2005,1999980.0 SM-TRANSCRIPTION,London School of Economics and Political Science,health,"The overall objective of this project is to study the initial phase of gene-transcription -i.e., the transformation of genetic information from DNA to RNA -at the level of individual molecules. State-of-the-art single-molecule fluorescence spectroscopy will be used in combination with a nanoscale 'spectroscopic ruler' (a method based on the phenomenon of fluorescence resonance energy transfer, also known as FRET) to capture the transient intermediates and conformational changes of RNA polymerase, the protein machine that orchestrates transcription. This analysis will complement the static snapshots of transcription complexes, which have been obtained using X-ray crystallography. Single-molecule fluorescence methods are well suited for real-time studies of initial transcription, since the available temporal resolution is sufficient for monitoring conformational changes during the addition of a single nucleotide to an RNA chain. The specific aims are to develop novel real-time assays for detecting promoter-DNA opening and promoter-escape in vitro; to use the in vitro assays for studying the effect of specific DNA sequences on promoter-proximal pausing and promoter escape; and to take the first steps towards developing similar single-molecule FRET assays that report on transcription in living bacterial cells. The proposed work will contribute to the understanding of initial transcription, providing insights applicable to the transcription systems of higher organisms such as humans. The proposed toolbox will also find extensive use in the study of other important protein-DNA interactions, both in vitro and in vivo.",A single-molecule view of initial transcription,FP7,31 August 2011,01 March 2010,172740.0 SMAC,STMicroelectronics Srl,information and communications technology,"Smart systems consist of heterogeneous subsystems and components providing different functionalities; they are normally implemented as “Multi-Package on a Board”. To fully exploit the potential of current nanoelectronics technologies, as well as to enable the integration of existing/new IPs and “More than Moore” devices, smart system miniaturization and “Multi-Chip in a Package” implementation are unavoidable. Such goals are only achievable if a flexible software platform (i.e., the SMAC platform) for smart subsystems/components design and integration is made available to designers and system integrators.",SMArt systems Co-design,FP7,03 June 2017,10 January 2011,0.0 SMALL,University of Nottingham,information and communications technology,"The overarching aim of the SMALL ITN project is to train Early Stage Researchers in the field of ‘molecular recognition at surfaces’ from fundamental science to novel applications. For this task, SMALL combines European experts from surface science, nanotechnology, theory, chemical synthesis, physics, biology and industry, and thus takes a highly integrated approach to the training. The researchers will work within a well-structured scientific programme aimed at molecular recognition, underpinning the next generation of molecular sensors, catalysis, biomimetics, and molecular electronics. The programme of training will foster scientists who, in addition to being specialists in particular branches of molecular nanotechnology, have broad interdisciplinary experience in the experimental and theoretical techniques of molecular nanotechnology. Their hands-on training will be substantiated by a well-developed network training programme which will address both scientific and complementary skills. In their projects, the Early Stage Researcher will explore the nature of the interactions responsible for molecular and atomic recognition and the role that these play in the massively parallel self-assembly of supramolecular nanostructures, using a collaboration of cutting edge experimental and theoretical techniques. They will investigate how to achieve chemical selectivity at surfaces, including enantioselective recognition, by molecular and atomic surface modification as a route to novel catalysis and nanoscale sensors, drawing on expertise across different scientific disciplines and pioneering industrial partnerships.",Surfaces for molecular recognition at the atomic level,FP7,12 July 2015,01 January 2010,4899085.18 SMALLINONE,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"A breakthrough of Proton Exchange Membrane Fuel Cells (PEMFC) requires a radical performances improvement of the key fuel cell material components (catalysts and protonic membrane) as well as highly innovative solutions to overcome the membrane assembly and integration limitations. Actual PEM fuel cells presents Membrane Electrode Assembly (MEA) architecture corresponding to a proton conductive membrane hot pressed between two catalytic electrodes. However, the MEA performance is limited by the interface effect between catalytic layer and membrane. To overcome this problem, the SMAllInOne project introduces a 'SMart All in One' membrane concept. In this approach, a catalytic network is directly implanted in the thin film protonic membrane. This novel composite material is particularly well adapted for fuel cell technologies as there is no boundary between the membrane and the electrodes. Moreover, several functionalities will be added to this material in order to confer it smart properties such as water and crossover management, tailored porosity and 3D conformability. The scientific and technological objectives of the project are: • To synthesize bifunctional polymerizable and volatile precursors (alkenyl & sulfonyl) to prevent the destruction of the acidic functions during the thin film membrane realization • To create a network of percolated platinum nano-particles inside both faces of the membrane to ensure simultaneously a good catalytic efficiency and electronic conductivity • To enhance electronic conductivity by a tailored doping of material with gold particles by the surface • To study and propose a water and crossover management solution by adding functional hydrophilic particles to keep the membrane wet and Pt particles to getter hydrogen linkage • To avoid the fuel depletion by controlling the porosity using a porogen approach The consortium consists of 7 partners from 5 European countries including 2 SMEs.",Smart Membrane for hydrogen energy conversion: All fuel cell functionalities in One Material,FP7,31 March 2012,01 April 2009,1825000.0 SMAMEMS,Autonomous University of Barcelona * Universitat Autònoma de Barcelona,manufacturing,"Shape memory alloys (SMA) exhibit unique and useful effects, such as a capacity to cycle a component between two different macroscopic shapes by cycling the temperature. In the recent years MEMS components made of shape memory alloys have attracted considerable interest in the research field as they offer a high output work density and exhibit specific desirable thermomechanical effects. As a consequence, many research studies have been focused on the development of shape memory thin films which could be integrated into the planar technology of microsystems. However, there are few works in the literature where the effects of the grain size (d)/sample size (D) ratio are studied, and those that do exist are insufficient to draw general conclusions.",Thermomechanical response of Cu-based shape memory alloys suitable for micro-electro-mechanical systems (MEMS) applications: interplay between grain size and sample size effects,FP7,02 May 2018,09 January 2013,0.0 SMART,Imperial College London,health,"The development of efficient drug carriers is a major challenge in the field of drug delivery. Most existing delivery systems do not deliver their cargo efficiently or are rapidly inactivated by the immune system leading to unwanted side effects or no effect at all. Shedding microvesicles are cell-derived membrane vesicles constituting the body's own intercellular 'shuttle service'. Due to their physiological constitution and stability in biological liquids these carriers hold great promise in fundamentally improving efficient drug delivery. The goal of this project is to assess the potential of shedding microvesicles as drug delivery vehicles by means of an innovative and broadly applicable assay for the detection of enzymes in living cells. Measurement of intracellular enzyme activity is crucial for the elucidation of molecular disease mechanisms and the development of efficient treatment strategies. The versatile enzyme assay is based on a novel nanoneedle system which allows parallel detection of intracellular enzyme activity. Nanoneedles are functionalized with different enzyme-specific, short fluorophore-labelled peptides. Once introduced into living cells, peptides will be cleaved intracellular releasing the fluorophore leading to a specific emission pattern depending on which intracellular enzymes are active. The assay constitutes a simple but broadly applicable technique for the measurement of any intracellular enzyme activity and can be adapted to monitor other cellular processes. In this regard, I propose to study shedding microvesicles and to develop them as unique drug loaded 'Trojan horses' using the versatile enzyme nano assay. These microvesicles have not been explored in-depth for drug delivery purposes. Thus, this project will pave the way towards a better understanding of successful drug delivery. It will enable a plethora of new treatment strategies which will be highly beneficial for patients and will strengthen scientific excellence in Europe.",Shedding microvesicles as drug loaded Trojan horses (SMART) -an exploration of unique drug carriers using a versatile enzyme nano assay,FP7,31 December 2015,01 January 2014,231283.0 SMART,Trinity College Dublin,information and communications technology,"The Advanced Materials Synthetic Research Team at Trinity College Dublin has developed a strong and growing reputation in the synthesis of electron rich materials. It has been the first to develop an intelligent and reproducible synthetic strategy for the generation of N-doped aromatic graphenes. These are SMART molecules whisch exhibit an unprecendented degree of aromacity and electron delocisation. The specific placement of N atoms within and at the periphery of these Carbon-rich materials confer tunable opto-electronic properties to the molecules and indicative of the potential for the application of these SMART systems as supermaterials in OLED and energy transport devices.The development of these molecular systems for materials and naotechnological applications, requires that the group maintains its lead in the field. It is vital that a strengthened interdisciplinary approach is taken to the synthesis, design, characterisation and testing of the molecules. The requirement is for new competency to drive the research forward and to set-up an international research group of high-standing. The new competence sought is compliments existing expertise but adds a new dimension to the areas of novel synthetic organic chemistry, excited state computational chemistry, coordination photophyiscs / electrochemistry, thin film formation and testing, and UHV surface science on large molecular systems. This critical momentum that will be achieved by a fuller treatment of our new N-doped but C-rich electronic materials will impact on the departmental, national and European effort in materials and nanotechnology.",Smart molecules for super materials,FP6,10 January 2010,11 January 2006,961704.0 SMART,Sapienza University of Rome * Università degli Studi di Roma La Sapienza,manufacturing,The study of living matter has to be considered as an exciting and substantive,Statistical Mechanics of Active Matter,FP7,10 July 2019,11 January 2012,0.0 SMART,IMEP-LAHC Laboratory,information and communications technology,"This SMART application proposes a technological breakthrough in the field of Atomic Force Microscopy (AFM). It aims at introducing Micro/Nano Electromechanical Systems (MNEMS) as a new generation of AFM probes having outstanding performances in terms of sensitivity and acquisition rate. More precisely, we aim at using bulk mode microresonators to drive an oscillating nanotip in the GHz range. Many applications are expected in the emerging fields of nanobiosciences. AFM systems have been widely used for 20 years in academic and industrial work. They give access to microscopy images at the nanoscale and derived techniques allow many physical characterizations. Many labs are currently trying to use the oscillating mode of AFM to probe biological nanosystems and their dynamics in a liquid environment. However, AFM performances are limited by the AFM oscillator itself. It is typically made of a tip supported by a cantilever beam whose oscillating properties are drastically degraded once placed in a liquid. This phenomenon is due to the hydrodynamic drag and the added mass of the liquid. Consequently, the resonant frequencies and quality factors are too low in liquids to support the force sensitivity and acquisition rate required to probe biological nanosystems dynamics. The SMART project proposes to change the overall AFM oscillator and to choose an oscillation mode in the GHz range that reduces the liquid velocity gradient around the resonator. This new generation of high sensitivity AFM force sensor will be an unprecedented tool for imaging biological and chemical systems at the nanoscale and the possibility of kinetic spectroscopy in liquids. AFM performances are expected to be increased by 3 orders of magnitude. The SMART investigator has a 10 year background in AFM and a 7 year experience in MNEMS resonators. Today, there is no project strictly similar to this one at international level. If successful, Europe could become a leader in this high level competition.",Scanning Microscopy using Active Resonating nanoTips,FP7,08 July 2015,09 January 2008,1500000.0 SMART NANOGELS,Free University of Berlin * Freie Universität Berlin,health,"Recent advances in medicine and biotechnology have prompted the need to develop nanoengineered delivery systems that can encapsulate a wide variety of novel therapeutics. Moreover, these delivery systems should be 'smart', such that they can deliver their payload at a well-defined time, place, or after a specific stimulus. The ideal drug delivery system should be biodegradable and biocompatible, should benefit from an active and passive targeting, should target only the desired cells, and should release its cargo (high loading capacity) at the desired intracellular space. In addition, recent trends in nanotechnology have developed the concept of theranostic, i.e., imaging, therapeutic and diagnosis in one. To date, only a few examples of nanocarriers that fulfil all of these criteria have been reported and therefore this research field still remains almost unexplored. In addition, the application of all these concepts to polymeric nanogels constitutes nowadays a challenge, and the achievements of the proposed objective will pave the road for future biological and biomedical applications of these polymeric systems.",Stimuli-responsive theranostic nanogels based on hyperbranched polyglycerol,FP7,31 July 2014,01 August 2012,167390.0 SMART-BIOMEMS,D'Appolonia SpA,information and communications technology,"Inherited human genetic characteristics govern the way people may be affected during their life from cardiovascular diseases, cancer, drug response. These illness represent the first three cause of death in worldwide population. The knowledge of genetic factors affecting human susceptibility to genetic-related diseases could enable physicians to safely adapt treatment to each patient. State-of-the-art techniques still suffer from time-consuming and labor-intensive procedures, which require costly and bulky equipment, as well as great quantity of costly reagents, taking several hours to deliver results. Due to needed tedious steps, these processes are also specially prone to human error. The development of rapid, low expensive and high-reliable methodology aimed at providing accurate information related to hundreds of genes in a few minutes is strongly deemed. The SMART-BioMEMS project aims to develop a novel DNA chip with fully integrated functionality, including sample preparation, amplification, gene detection and data processing, ideally suited for ultra-fast, cost-effective point-of-care genetic analysis. Latest advances in MEMS (Micro Electro Mechanical System) technology will be addressed, possessing the appropriate potential to enable complete DNA analysis, with increased functionality and performance, at reduced costs due to the optimised consumption of costly reagents. As well, innovative active flow control elements will be integrated with the chip to precisely move minute amounts of DNA sample and reagents in a controlled way, thus maximising the performance of the whole lab-on-a-chip system. Finally, advanced optical flow visualization techniques, including micro-PIV (Particle Image Velocimetry) and LIF (Laser Induced Fluorescence), and special micro-fluidic CFD-applications will be developed to locally quantify the flow through the micro-fluidic channels, thus leading to significant improvement in the optimisation of micro-fluidic device performance.",Development of an Integrated MEMS (Micro Electro Mechanical System) based DNA Analysis Chip with Active Flow Control Components,FP6,31 May 2009,30 November 2005,2096000.0 SMART-EC,Research Center Fiat * Centro Recherche Fiat (CRF) SCPA,energy,"SMART-EC aims at the development of self powered (energy harvesting and storage) EC device integrating EC thin film transistor component on a flexible substrate for energy saving, comfort and security in automotive, e-cards and smart packaging sectors. The objective is to overcome the current limitations related to low switching time and manufacturing costs; the switching time can be reduced (<1s) by introducing nanostructured EC materials, innovative EC transistors and high ionic conductive solid electrolytes. Radical innovative cheap manufacturing technologies on large area PVD, inkjet and roll-to-roll processes on low cost plastic will be developed. These processes are fully compatible with heterogeneous integration of several functions to produce a completely autonomous device (thin film battery, PV cell, sensors and communication) with great added value respect to traditional solutions. The optimization of co-integrated (separated building blocks laminated together) and convergence (using same materials for different building blocks) approaches will allow to fabricate a fully autonomous system. The first step will be the optimization of deposition and patterning technologies in terms of processes parameters and in-situ monitoring to allow the high control of film growth; the second step will be the heterogeneous integration of the different building blocks to produce the self-powered systems for the targeted applications. Four academic and research institutes guarantee a high level interdisciplinary research on solid-state physics, material chemistry and integration; this will assures the proper technology transfer to industrial partners at all product chain levels (materials, devices and end users) for a successful exploitation of results. SMART-EC materials and technologies are original and will pave the way for future generation smart surfaces with great potential impact at medium and long term (flexible and transparent electronics) applications.",Heterogeneous integration of autonomous smart films based on electrochromic transistors,FP7,31 August 2014,01 September 2010,5100000.0 SMART-NANO,Centre Suisse d'Electronique et de Microtechnique (CSEM) - Recherche et Developpement,environment,"SMART-NANO will develop an innovative, cost-effective technology platform that provides a total solution “from sample-to-result” for the detection, identification, and measurement of nanoparticles in complex matrices in Consumer Products, in Food, in the Environment and in situ in Biota. A key innovation is the miniaturized, application-specific, cartridge-based system integrating separation, detection, and quantification. On top of this CORE innovation, plug-in modules for sample preparation, high sensitivity size measurement, and hypersensitive identification, provide the necessary sensitivity and flexibility to this technology platform. Highly innovative approaches also lie in the supercritical CO2 isolation of Engineered Nanoparticles (ENPs) from complex matrices and the ICP-MS based hypersensitive identification of ENPs.","Sensitive MeAsuRemenT, detection, and identification of engineered NANOparticles in complex matrices",FP7,05 July 2018,06 January 2012,0.0 SMARTCANCERSENS,"Institute of Technology, Tallaght",health,"Oncologists still rely heavily on biological characterisation of tumours and a limited number of biomarkers which have demonstrated clinical utility. Routine cancer diagnostic tools may not be always sensitive enough and may only detect proteins at levels corresponding to an advanced stage of the disease. Recently, new genomic and proteomic molecular tools (molecular signatures) are being employed which include genetic and epigenetic signatures, changes in gene expression, protein profiles and post-translational modification of proteins. Such advanced diagnostic tools are not always readily adapted to clinical cancer screening due to their complexity, costs and the requirement for highly-qualified operators. Novel bioanalytical methodologies for detection of specific biomarkers/ biomolecules, based on nanostructured electronic sensors (rapid, sensitive devices capable of miniaturisation and deployment on site or in small clinics), fulfill the necessary requirements and have the potential to compliment time- and labour consuming clinical analysers used in medical laboratories currently. The primary objective of this proposal, therefore, is to gather together an international and interdisciplinary consortium of ten research teams from EU Member States, Third (including ENP) countries with EU agreements on S&T, in order to share and jointly exploit knowledge and expertise in the development of micro/nanosensors as tools in early cancer diagnosis. A key scientific target is the realisation of intelligent electronic devices which respond to biomolecules such as formaldehyde, amines, metal ions, saccharides, activities of amine oxidases, arginase and glutathione-S-transferase. This will entail design, development and characterisation of nano-scale transducers suitable for testing in clinical samples.",Micro/nanosensors for early cancer warning system - diagnostic and prognostic information,FP7,31 December 2016,01 January 2013,584800.0 SMARTDRUGENTITIES,Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.,health,"I propose to develop sophisticated anti-tumor agents targeted particularly to the location of activity. My team has recently introduced a new family of Ti(IV) complexes that demonstrates higher activity than known compounds with substantially higher stability and defined hydrolytic behavior, properties that were found to be essential. I propose to study various derivatives and identify the parameters affecting activity, including steric and electronic effects, enantiomeric purity, ligand lability etc., and elucidation various mechanistic aspects of reactivity. More importantly, I propose to construct pH-sensitive transport units that will allow protection of the sensitive active species throughout their delivery and release only near the target location based on the variable pH conditions of different human tissues. In particular, unique spherical molecules held together by metal-ligand interactions will be prepared. The building blocks will consist of the planar ligands of C3-axis bound to three biocompatible Ti(IV) ions each with defined angles and geometry. The resulting spherical compounds will be utilized to encapsulate the active complexes and release them upon hydrolysis at the desired pH based on the pH-dependent hydrolysis pattern already established for related compounds. Preliminary calculations have confirmed the possibility of forming these compounds, which are particularly matching in their expected size to encapsulate our complexes. Larger spheres will also be prepared as cavities for larger molecules, which may be linked together for the delivery of multiple drugs. These compounds may find applications in various areas where a protected environment or delivery of sensitive compounds is required, such as in gene therapy, nano-technology, and catalysis.",Sophisticated Well-Targeted Therapeutic Entities based on Biologically Compatible Ti(IV) Active Cores and Building Blocks,FP7,30 September 2014,01 October 2009,1400000.0 SMARTFIBER,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,energy,"In this project, we will develop a smart miniaturized system which integrates optical fiber sensor technology, nano-photonic chip technology and low power wireless technology. The smart system will enable for the first time fully embedded structural health monitoring of composites used as structural parts in e.g. wind turbine blades, satellites, airplanes, civil constructions, oil and gas wells, boat hulls. Due to the innovative approach of integrating micro-technologies, SMARTFIBER will demonstrate a smart system so small (order mm's) that it can be embedded as a whole in the fiber reinforced polymer. As such, the system takes away the main technical roadblock for the industrial uptake of optical fiber sensors as structural health monitoring technology in composite structures: embedding of both fiber sensor and fiber interrogator omits the fragile external fiber coupling to an external interrogator. SMARTFIBER will drive ICT to make truly intelligent composites. The technologies to be integrated –optical fiber Bragg grating sensors, nano-photonic chip technology and low power wireless technology- have all proven practicability. SMARTFIBER envisages the high risk of integrating the technologies to a system that both complies with the composite manufacturing process and performs well when embedded in a fiber reinforced polymer. The technology will be integrated and demonstrated in a real production environment. The large industrial involvement in SMARTFIBER is significant. The value chain of the microsystem is fully covered by the partners' activities. This strategy gives industrial take-up and commercial development of the technology a huge chance. The smart miniaturized systems will provide the user a continuous record of structural data which will inform decisions on maintenance, thereby obviating the need for expensive, periodic maintenance, as well as warning of potentially catastrophic mechanical failures, increasing safety remarkably.",Miniaturised Structural Monitoring System with Autonomous Readout Micro-Technology and Fiber sensor network,FP7,28 February 2014,01 September 2010,3050000.0 SMARTGATE,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),information and communications technology,"Ultra-low voltage/power operation is expected to be an important requirement for future nanoelectronics allowing more dense and fast circuits on one hand and enabling the operation of energy efficient intelligent autonomous systems on the other. In present day devices quite a lot of power is consumed during switching since it requires a minimum bias of 60 mV on the gate to overcome a potential barrier and increase the transistor current by a decade, a process which is fundamentally limited by thermal Boltzmann statistics. We propose the development of novel negative capacitance “smart” gates with a positive feedback and internal amplification to overcome the “Boltzmann tyranny” and obtain steeper slope “green” transistors capable of operating at very low voltage. Metallic systems with a low density of states could provide the required dominant negative contributions to the capacitance due to strong carrier correlation effects. Such metallic systems made of 2D Dirac fermions with linear dispersion bands are supported in graphene and on the surface of the newly discovered topological insulators having the very interesting property that they offer a nearly zero density of states at the band crossing near the charge neutral point. We propose here the graphene and Bi2Se3-based topological insulators as the key components of the targeted “smart” gates. We aim at developing complex gate structures facing the challenges of growth of high purity and high crystalline quality graphene and Bi2Se3 thin films in combination with conventional dielectrics and metals on Si semiconductor in an effort to obtain the required properties and ensure their robust functionality at room temperature. Possible negative capacitance effects will be investigated in terms of generic capacitor electrical characterization, while transistor devices with optimum smart gates will be fabricated to prove the principle of steep slope switching.",Smart Gates for the 'Green' Transistor,FP7,12 July 2017,01 January 2012,1221611.0 SMARTHEALTH,University Newcastle upon Tyne,health,"Driven by clinical applications and MNT and IST technology, SmartHEALTH will develop an open integrated architecture for new biodiagnostic systems to support European companies exploiting bioassays or new application concepts. Initial system has a disposable fluidic cartridge with a desktop basestation linking to the ambient eHealth environment - health cards, patient data, online services. This concept will be miniaturised and cost engineered into a portable and consumer product. It will perform multianalyate sensing and interpretation, for nucleic acids, proteins and others and will handle multiple biological sample types. Results will be interpreted and presented using bioinformatics. Systems will be healthcare user identity and ambient environment aware, respecting confidentiality and information access rights. The IP will enable enhanced medical diagnosis, leading to earlier and more precise results contributing to an increased quality of life as well as increasing the competitiveness of the European IVD sector. The IP will include: selection of probes, sample preparation, fluid handling, concentration, filtering; sensors and transducers, (label free systems and rapid nucleic acid detection systems); surface modification/integration of nanoscale elements; system development - controllers, actuators, data processing, communications and integration with ambient intelligence, on-line information services; understanding of fit to healthcare, input to medical management - user factors, costs, approvals, regulations, ethics. Clinical areas are in Cancer Diagnostics - breast cancer recurrence monitoring, cervical cancer case finding, colorectal cancer - diagnostic/theranostic/prognostics. Each application includes clinical validation and commercial exploitation partners. The consortium is a powerful set of 3 Universities, 9 Research Institutions, 10 SMEs, 4 larger Companies and 4 Clinical Groups covering all the relevant issues.",Smart Integrated Biodiagnostic Systems for Healthcare,FP6,30 June 2010,30 November 2005,1.229821134E7 SMARTMET,Max Planck Institute for Iron Research * Max Planck Institut für Eisenforschung,health,"The design of advanced high strength and damage tolerant metallic materials for energy, mobility, and health applications forms the engineering and manufacturing backbone of Europe's industry. Examples are creep-resistant Ni-alloys in power plants and plane turbines; ultrahigh strength steels, Al- and Mg-alloys for light-weight mobility and aerospace design; or Ti-implants in aging societies. Since the Bronze Age the design of metallic alloys rooted in trial and error, owing to the complexity of the physical and chemical mechanisms involved and the engineering conditions imposed during manufacturing. This traditional approach has two shortcomings. First, current alloys are not developed via systematic design rules but via empirical methods. This approach is time consuming and inefficient. Second, the increase in strength via traditional hardening mechanisms always causes a dramatic decrease in ductility, i.e., making the material brittle and susceptible to failure. SMARTMET aims at solving this inverse strength-ductility problem: The joint use of advanced synthesis and atomic characterization (expertise of PI) together with ab initio modeling (expertise of Co-PI) opens a new path to the design of next generation metallic alloys. The objective is to use these methods to identify and utilize strengthening mechanisms that allow to overcome the inverse relationship between strength and ductility. The key idea is to incorporate phases into alloys that are close or beyond their mechanical and thermodynamic stability limit. They undergo transformations under load acting as self-organized repair mechanism. SMARTMET contains risks and gains: (i) Mechanical stability through unstable phases includes the risk of material weakening but it may break the inverse strength-ductility principle. (ii) New metallurgical alloys (PI) designed via quantum mechanics (Co-PI) is risky owing to the complexity of metallic nanostructures but allows alloy tailoring based on first principles.",Adaptive nanostructures in next generation metallic materials: Converting mechanically unstable structures into smart engineering alloys,FP7,31 January 2017,01 February 2012,2920000.0 SMARTNANOTUBES,University of Trieste * Università degli studi di Trieste,health,"'The ability to miniaturise devices has completely changed our society and modern technology is constantly pushing towards smaller and lighter devices with enhanced and more diverse functionalities. Future technologies will increasingly rely on materials that respond to their environment in a manner that suggests a degree of ''intelligence'' and nanoscience may offer many of the tools and opportunities that are required in order to a build a foundation for the next scientific revolution. The design of a library of carbon nanotubes functionalized with task-oriented molecules for the development of responsive, i.e. “smart†nanomaterials is the main focus of this interdisciplinary research program. The nanodevice itself will be composed of a carbon nanotube because it offers biocompatibility as well as the necessary structural scaffolding. In order to render the vehicle soluble and stable in water, the nanotube will be suitably functionalised on the surface. In order to make this into a smart material, a molecular switch will be covalently attached to the vehicle. The role of the switch is to activate the drug delivery system or to function as a sensor. Once the switch is triggered by the external stimulus (such as light, heat, chemicals or changes in pH) it will undergo a conformational change that can release biologically active ions and molecules in a controlled manner. Alternatively, the switch can be constructed such that it responds to specific chemical inputs (such as different metal ions or amino acids). Finally, the possibility of using the nanotube (which has excellent thermal conductivity) as a light/heat-absorbing antenna that can transmit energy directly to the attached switch will be explored. If near-IR radiation could be used as input/trigger for this kind of delivery/sensing vehicle it would represent a major breakthrough because such radiation is of low energy and relatively harmless to human tissue and biotic systems.'",Synthesis of smart materials: Functionalizing nanotubes with molecular switches,FP6,31 August 2007,01 September 2006,40000.0 SMARTNET,Technische Universiteit Delft * Delft University of Technology,manufacturing,"SMARTNET (“Soft materials advanced training networkâ€) is an ITN at the interface of chemistry, physics, and biology, and deals with the science and technology of molecular soft materials. Soft matter (e.g. gels, emulsions, membranes) is of great societal and economic impact in fields such as food industry, cosmetics, oil extraction and increasingly in high value areas such as biomedicine and nanotechnology. Soft matter is formed when fluids are mixed with molecular additives, giving rise to molecular level structuring. Polymers and inorganic materials have been widely used in this context, but are unlikely to meet future performance requirements for high-tech applications. SMARTNET is focused on conceptually novel approaches towards the next generation of soft matter, based on self-assembling small molecules as promising alternatives to existing systems. The design of molecular components and control of self-assembly processes allows for organization across length scales leading to emergent properties and functions, and will impact on 21st century health care, biomedicine and energy-related technologies. SMARTNET provides a unique multidisciplinary training opportunity and a step change in understanding and exploitation of these systems. A competitive advantage will be achieved by close integration of world-class expertise in molecular design, self-assembly and nanofabrication, photo-chemistry and -physics, multiscale modeling, state-of-the-art scattering and spectroscopy, with application areas such as biomedical, opto-electronic and catalytic materials. SMARTNET consolidates, through international and cross-disciplinary coordination and integration of 9 teams, leading EU research efforts in the area of supramolecular soft matter and offers unique opportunities to the highest level of training-through-research projects.",Soft Materials Advanced Research Training Network,FP7,10 July 2018,11 January 2012,4129500.0 SMARTONICS,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,photonics,"The target of the Smartonics project is the development of Pilot lines that will combine smart technologies with smart nanomaterials for the precision synthesis of Organic Electronic (OE) devices. The Smartonics objectives are: 1.Development of smart Nanomaterials for OEs (polymer & small molecule films, plasmonic NPs and super-barriers) by process and computational modeling optimization. 2.Development of smart Technologies (r2r printing and OVPD machines combined with precision sensing & laser tools and processes). 3.Integration of Nanomaterials & Technologies in Pilot lines for precision synthesis of Nanomaterials & OE devices, optimization, demonstration and evaluation for Industrial applications. Smartonics will develop three Pilot lines: a) OVPD Pilot line equipped with in-line optical sensing tools, b) r2r printing Pilot line, which will combine optical sensing and laser processing tools, and c) s2s Pilot line for the precision fabrication of OE devices (e.g. OLEDs, sensors from state-of-the-art Nanomaterials) and for the evaluation of encapsulation of these devices. The above will be up-scaled in Industrial processes. More specifically: - The parameters for small molecule OPVs will be up-scaled to Industrial scale OVPD machine. - The process parameters for r2r OPVs will be up-scaled and demonstrated in r2r printing machines. - The advances and precision in the synthesis of nanomaterials by the optical sensing tool will be evaluated for flexible displays. - The advances for the r2r printing process will be evaluated for large-scale production of OPVs. - The flexible OPVs will be validated and implemented in automotives applications. All the above are consistent with the topic NMP.2012.1.4-1 since the the targets of project are including the development of Pilot lines that will be combined with production machines (gas (transport and printing), precision and fabrication tools and processes for the precision synthesis of Nanomaterials and OEs.","Development of smart machines, tools and processes for the precision synthesis of nanomaterials with tailored properties for Organic Electronics",FP7,31 December 2016,01 January 2013,7987000.0 SMARTPIEZOCOMPOSITE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"The project proposal addresses field of 'smart' piezoelectric materials based on polymer-inorganic nanocomposites. The research will be divided into following main sub-streams: investigation of nanocomposites based on poly(vinylidene fluoride), investigation of materials based on poly(L-lactic acid) and study on the influence of differently shaped nanoparticles on crystallization and general phase behavior of the materials. For the purpose of this project, the nanocomposites will be prepared by compounding either in solution or in the melt and also by methods based on chemical synthesis. The main efforts will be directed at finding factors essentially affecting polymer-nanoparticle interactions in order to control both the polymorphism and mutual orientation of nanoparticles and structure units at the nanoscale. Achieving this goal is crucial as it defines the possibility to render the materials piezoelectric. It is expected that spatial orientation of anisometric nanoparticles in the molten polymer matrix will force the polymers to crystallize in certain preferred direction and crystal structure, which will enable formation of piezoelectric materials using simple methods typical for processing of thermoplastics as e.g. injection molding. From the technological point of view, such an improvement will allow to simplify the production methods of piezoelectric plastics and also will reduce the production costs of such materials. Currently, the state-of-the-art piezoelectric polymers are processed mainly to the form of foils and fibers, which limits the area of their possible application in devices. The main improvement proposed in this research relies on the possibility to process the nanostructured material to complex geometries, which will expand the field of potential application -especially in robotics, measuring devices and monitoring systems.",Crystallization of Polymers in the Presence of Inorganic Nanoparticles - a Way Towards Piezoelectric 'Smart' Nanocomposites,FP7,30 September 2012,01 October 2010,168969.0 SMARTPTDRUGS,The University of Edinburgh,health,"Chemistry has made major contributions towards fighting cancer (Europe's major cause of death) by developing small molecules which can act as anticancer drugs. But despite extensive research efforts, defeating cancer is proving to be an enormous challenge. Inorganic chemistry has made its most important contribution in the form of platinum (Pt) complexes, which provide highly effective chemotherapy for testicular, ovarian, neck, cervical and esophageal cancers. Drug resistance and toxic side effects means that there are many occasions when Pt-based treatment must be discontinued and limit the ability of Pt drugs to cure other forms of cancer such as the more common colon and breast cancers. The problem is that the drugs are not 'smart' -they are not capable of identifying cancer cells and they react with a wide range of molecules. Another significant limitation is that it is not possible to control when and where they exert cytotoxicity. Here we propose a novel methodology to make: 1) Pt complexes capable of identifying cancer cells, 2) Pt drugs with a built-in security device –a switch which we can turn on externally to make the Pt drug active only when it reaches the tumour.",Fluorescent nanocrystals for activation and delivery of platinum drugs,FP7,30 September 2012,01 October 2010,173240.0 SMARTSTRUCTURES,University of Bristol,health,"In this proposal, we intend to combine the advantages of virus and polymersome structural motifs into one integrated model as a promising strategy to construct hybrid structures that are efficient delivery vehicles. First, folic acid-modified polyN-(2-hydroxypropyl)methacrylamide-poly(L-cysteine) conjugate (FA-PHPMA-b-PLC) will be synthesized. The biocompatible PHPMA is used as the hydrophilic part, and PLC is chosen for its ability to aggregate in water (by either hydrogen or covalent bonding via beta-sheet formation or disulphide linkage). Not only do the thiol groups in PLC chain play an important role for covalent loading of drugs/proteins/genes via thiol exchange with disulfide groups, but also the oxidation of the cysteine residues to form intra- and intermolecular disulfide bridges further stabilize the polymersome structure. After forming the polymersome, the biomolecules will be incorporated by either covalent or noncovalent mechanisms. Finally, zinc oxide nanoparticles modified by disulfide-linked pyridine will be covalently encapsulated into the PLC shell to obtain the hybrid virus-like structure with ZnO nanoparticles as a key component of the coronal layer. We anticipate that the constructed hybrid structure will enter the target cell by endocytosis. The low pH in the endosome (pH~5) will then accelerate the dissolution of the ZnO nanoparticles and release the biomolecules. Subsequently, glutathione in the cytoplasm will reduce the cross-linked disulfides in PLC shell and lead to the disassembly of the polymersome. Therefore, as a new hybrid structure that integrates significant advantages of both the polymersome and virus models of biomolecule delivery, it is reasonable to believe that it will provide a new advance for the design of delivery vehicles for the cure of cancer-related diseases.",Synthesis of Smart Virus-like Hierarchical Structures Based-on Polymer-Peptide Conjugates and the Potential Application in Drug Delivery,FP7,30 June 2014,01 July 2012,209033.0 SMD,Consorzio per il Centro di Biomedicina Molecolare (CBM),health,"Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measurements. We will design and fabricate novel devices for the generation of plasmon polaritons as well as combine photonic crystals and plasmonic nanolenses. These new devices will be able to detect few/single molecules through Raman, InfraRed and Terahertz (THz) signals and in combination with Atomic Force Microscopy and Optical Tweezer force spectroscopy with a spatial resolution in the sub-10 nm for Raman and IR and sub-100 nm for the THz region. The complete characterization of single unknown molecule will be demonstrated through: i- investigations on the chemical and physical properties of membrane receptors, such as rhodopsin, odorant receptors and ionic channels; ii- identification of new molecules involved in cancer development and metastasis. The new devices will allow the acquisition of THz images and we will explore the possibilities of this new spectral region for biomedical scanning. The SMD proposal is based on an original idea of the coordinator, prof. E. di Fabrizio and will be exploited thanks to the complementary expertise present in the different sites and to a tight coordination between the various groups. The design, fabrication and testing will be performed at UMG, TASC and CBM Integration in a single instrument will be carried out at TASC, CBM, IIT Nanotec, RUB. Validation activities will be performed by all the partners taking advantage of the world leading expertise of the TUDO and the STRATH- AC in spectroscopy of natural and artificial biological systems. The SME NANOTEC and CBM will provide the commercial exploitation of the obtained results.",Single or few molecules detection by combined enhanced spectroscopies,FP7,30 June 2012,01 July 2009,3421500.0 SMDR,University of Bath,health,"This project will develop a new paradigm in spinning disc process intensification technology: the spinning mesh disc reactor (SMDR). The SMDR uses a high surface area rotating mesh supporting a catalyst to create process intensification. A liquid is centrifugally forced and accelerated into the mesh creating rapid mixing and increased heat and mass transfer rates compared to conventional reactors, accelerating reaction rates. It is superior to conventional spinning disc reactors as the mesh keeps all of the catalyst in the intensified (spinning) reaction zone and helps to protect these catalysts from deactivation from excessive hydrodynamic forces, allowing fragile nanostructured catalysts and enzymes to be used. Therefore the aim of this research is to fully characterise the SMDR for two important reaction systems: (1) nanostructured photocatalytic systems for the degradation of harmful trace pharmaceuticals in wastewater, (2) enzymatic biochemical transformations of waste oils (in particular to biodiesel). Reaction rates and mechanism, mass transfer effects, catalyst reusability and durability, all compared to conventional reactors, will be evaluated both experimentally and mathematically. Residence time distributions, high speed camera analysis of mesh flows and computational fluid dynamics will be used to evaluate reactor hydrodynamics and operation. This project will enable Dr Patterson to successfully integrate into the EU by providing him with a secure basis from which to transfer, build and extend his existing research base from New Zealand to the University of Bath. It will provide him and his research group with the funds to access the analysis and characterisation equipment needed to produce high impact research. Ultimately this grant will provide the foundation from which Dr Patterson will build a world leading group in the EU in the area of Nanostructured and Tuneable Materials for sustainable applications in Separation and Reaction Engineering.",Spinning Mesh Disc Reactors: A New Paradigm for Photocatalytic and Enzymatic Reaction Intensification,FP7,31 March 2017,01 April 2013,100000.0 SME-SAT,University of Surrey,transport,"Fueled by mass market demand, terrestrial consumer electronics continue to drive technology advancement in the field of microelectronics devices. Many of these technologies are spearheaded by the contributions of Small and Medium Enterprise (SME). There is a clear opportunity to revolutionize space technologies by leveraging advancement in the commercial electronics market. However, despite the obvious benefits to the space industry, it remains difficult for SMEs to get involved due to the significant cost, effort, time, and paper work to qualify parts for space applications. A trend toward smaller and cheaper satellites allows for a novel approach to space qualification and testing. Nanosatellites (between 1kg and 10kg) can be launched at a relatively low cost as piggy back payloads for larger satellite missions. Since the cost of failure is an order of magnitude lower than conventional satellites, nanosatellites offer an ideal platform for high risk demonstration missions.",Small and Medium Enterprise Satellite (SME-SAT),FP7,12 July 2017,01 January 2013,0.0 SMI-DDR,University of Sussex,health,"Accurate DNA replication is key to maintaining genomic stability. Replication is immensely complex requiring error-free duplication of several billion bases each time a human cell divides. The DNA replication machinery must deal with a wide range of DNA damage, aberrant secondary structures and DNA:protein complexes; obstacles that cause replication forks to arrest. Arrested replication complexes are actively stabilised by checkpoint pathways, but in some cases component proteins still dissociate from the site of DNA incorporation, resulting in fork ¿collapse¿. Collapsed forks can be restarted by homologous recombination (HR)-based processes, but are strongly associated with gross chromosomal rearrangements. Thus, the advantage gained by restarting a collapsed fork comes at the expense of an increased potential for genome instability. Structural, biochemical, and molecular techniques identified the main components and regulators of these processes, but are inherently limited to studying the system in bulk, thereby averaging events and limiting our understanding of the dynamics and behaviour of molecular participants. To overcome these limitations and to study single molecules at a single arrested or collapsed fork I propose to develop an nTIRF-PALM ¿super-resolution¿ microscopy platform that will allow the identification of individual protein molecule as well as very small numbers of molecules at <50 nanometer resolution inside the nucleus of a living eukaryotic cell. I propose to apply this methodology to the model organism fission yeast (S. pombe) to study the organization and structure of normal and restarted replication forks. To achieve this I propose to extend the development of site-specific and temporally controlled replication fork arrest systems to manipulate a single replication fork at a defined DNA locus. By creating a variety of fluorescent protein tags we will record 'molecular movies' to provide insight into the dynamics and reaction mechanisms.",Single Molecule Imaging of the DNA Damage Response in Live Cells,FP7,30 April 2016,01 May 2011,2366576.0 SMILE,Aristotle University of Thessaloniki * Aristotelio Panepistimio Thessalonikis,health,"Although the detailed pathophysiologic triggers responsible for the individual natural history trajectory of each atherosclerotic plaque are unknown, the local, dynamic interplay between low endothelial shear stress (ESS) and vascular inflammation is likely to be critical. The purpose of the proposed project is to combine ESS with inflammation in a plaque risk classification scheme aiming to predict high-risk plaque at early stages of its development before its rupture. Enhancing our understanding of the magnitude of local hemodynamic stimulus with respect to inflammation (i.e. ESS), as well as the extent of local inflammation would allow us to detect early, minimally stenotic, atherosclerotic lesions and stratify the risk of them evolving into high-risk plaques. The latter classification is of utmost clinical importance as it can provide a rationale for innovative diagnostic and/or therapeutic strategies for the management of coronary patients, as well as the prevention of acute coronary syndrome. Identification of a high-risk plaque at its early stages of development would potentially justify highly selective, prophylactic local interventions, such as implantation of stents or targeted nanoparticle-based delivery of anti-inflammatory drugs, supplemented by an intensive systemic pharmacologic approach to limit the severity of inflammation, stabilize the plaque, and thereby avert a future acute coronary event. The clinical and economic implications of identifying and treating high-risk individual coronary lesions before an adverse cardiac event can occur are anticipated to be enormous.",Combination of Shear Stress and Molecular Imaging of Inflammation to Predict High-Risk Atherosclerotic Plaque,FP7,11 April 2014,12 April 2010,100000.0 SMILEY,National Research Council * Consiglio Nazionale delle Ricerche (CNR),energy,"SMILEY aims to develop and apply a 'bottom-up' approach to build nano-structured devices with smart multi-functional properties: bio-mineralization, self-assembly, self-organization are an ensemble of concomitant phenomena, inspired by nature, that will be properly directed to generate elementary nano-sized building blocks organized in macroscopic devices for application in EHS (Environment, Health, Safety) Biomedical and Energy fields. SMILEY will exploit the ability of such a cascade of biologically-inspired processes to form complex hybrid nano-composites, starting from abundant and environmentally safe raw materials such as natural polymers and fibres, whose characteristics and organization are mediated by the activation of control mechanisms and structural confinement conferring defined functionalities to the final devices. The processes of self-assembling and mineralization, scaled at pilot plant, will be directed and adjusted to obtain 3-D porous hybrid nano-composites to be used as: i) filters for air purification from nano-particles; ii) biomedical devices exhibiting high mimesis with human hard tissues, addressed to dental regeneration; iii) fibrous integrated photovoltaic devices. The control mechanisms inherent in the whole process will allow to establish a technological platform based on highly repeatable, scalable and cost-effective technology for the manufacturing of multi-functional devices with huge economic, environmental and social impact. This will also represent a proof of concept for further development of smart devices obtained by biologically-inspired self-assembling processes; in this respect, roadmaps addressing wider industrial exploitation will be prepared, basing on the knowledge gained in the development of SMILEY.",Smart nano-structured devices hierarchically assembled by bio-mineralization processes,FP7,30 November 2015,01 December 2012,3996103.0 SMONDEP,İzmir Institute of Technology * İzmir Yüksek Teknoloji Enstitüsü,photonics,"This research activity aims to demonstrate an economically viable and scalable nano-manufacturing method using a modified Chemical Vapor Deposition technique and a nano pattern transfer method based on silicon nanomembrane technology for the fabrication of nanostructured polymeric device components for electronics and photonics. The multidisciplinary nature of the proposed research will fuse science and engineering to overcome technological roadblocks for heterogeneous integration of polymeric materials into conventional micro- and nano-fabrication processes. The economically viable and scalable nano-manufacturing methods will enable the use of polymeric materials in conventional & future device designs opening new opportunities for electronic and photonic applications. The research will also address the need for novel polymeric materials with better chemical and thermal stabilities, and scalable processes that can take advantage of these chemistries to fabricate electronic/photonic devices reliably at low temperatures and at a reduced cost. The proposed method of integration of polymeric nanostructures into conventional nano-fabrication processes is scalable to a wafer size process and can also be optimized for roll-to-roll processing. The proposed work will advance the use of polymeric materials in semiconductor manufacturing in a real and significant way.",Scalable Manufacturing of Organic Nano Devices for Electronics and Photonics,FP7,31 July 2016,01 August 2012,100000.0 SMS-STM,Lawrence Berkeley National Laboratory,information and communications technology,"This project consists on the study of the interaction of single molecules on surfaces and their manipulation with a Low Temperature Ultra High Vacuum Scanning Tunnelling Microscopy (LT UHV STM). In order to study the interaction between single molecules, the electronic and vibrational properties of individually selected and targeted molecules will be measured.The project can be divided into two parts:The first part, carried out during the outgoing phase of the project, will be dedicated to study the interaction of water with different systems. First, the interaction of water with hydrophobic and hydrophylic molecules will be studied in order to understand the wetting of water at the molecular level. After that, the interaction of water molecules with biological molecules such as aminoacids and nucleotides will be studied. The exact atomic positions at the water-adsorbate and water-surface interfaces will be determined by means of electronic and vibrational spectroscopy and arranging a controlled envirnonment by manipulating the molecules with the STM tip.The second part, carried out in the re-integration phase, will consist on the study of the electronic properties of nano-objects, focusing on single organic molecules that can be used in molecular electronics. The main part of the project will consist on how these are integrated into the electronic devices, i.e. the interface between the molecules and the leads. In order to understand the effect of the leads on the electronic properties of the molecules, a precise analysis is needed at the atomic scale, and LT UHV STM has proved so far to be the only technique capable of relating in-situ atomic structure to electronic properties.The interest of the project covers a large number of fields, such as nanoelectronics, nanocatalysis, biophysics or environmental science.","Single molecule on surfaces: manipulation and study of chemical, electronic and vibrational properties with a low Temperature Ultra High Vacuum Scanning Tunnelling Microscopy",FP6,14 October 2007,15 April 2005,207562.0 SMSMS,Autonomous University of Barcelona * Universitat Autònoma de Barcelona,photonics,"The aim of this project is to build an experimental set-up for single molecule fluorescence detection with the goal of studying multichromophoric systems with potential application in nanotechnology. Single molecule fluorescence spectroscopy (SMFS), a powerful tool to address the behaviour of matter at the nanoscale, has nowadays evolved to a new frontier in science with high impact in a wide range of disciplines. One of the areas where SMFS has found a widespread application is in the investigation of multichromophoric assemblies, an issue of current interest due to the unique optical properties displayed by those systems, which are promising components for molecular photonic and electronic devices. Herein two types of artificially synthesised chromophoric assemblies will be studied. First, attention will be focused on model systems where excitation energy transfer takes place between coupled units of donors and acceptors. An enhancement of the energy flow efficiency is expected for those systems. This mechanism will be studied at the single molecule level and, subsequently, applied to build and investigate long dye arrays susceptible to allow for energy flow over Iarge distances. To develop this project, the applicant has already reintegrated to a research institution in his own country with a contract for a period of five years. The experience of the host group with the synthesis of chromophoric systems will complement the applicant and apos;s expertise on the SMS field acquired during the initial Marie Curie action in the University of Twente, then ensuring the successful development of the project. The applicant will acquire a fruitful training in nanoscience and nanotechnology during the reintegration period, two thematic priorities of the 6th Framework Programme of the EU. This will benefit the applicant and apos;s long-term job stability in the framework of several research centres in nanotechnology recently launched in his region of origin.",Building a set-up for single molecule fluorescence detection. Application to the study of multichromophoric systems with application in molecular photonics and electronics.,FP6,30 June 2005,01 July 2004,40000.0 SMW,TILL I.D. GmbH,health,"This proposal aims at the development and application of an innovative single molecule workstation, enabling advances in the research happening throughout Europe and the rest of the world around the investigation of living cells. By combining three most advanced microscopic techniques into a single workstation, we aim at reaching a new quality level in the study of the molecular biology of living cells. The proposed single molecule workstation will be composed of three key elements: (i) inverted light microscope (ILM); (ii) atomic force microscope (AFM); and (iii) optical tweezers (OT). A true virtue of this initiative is that by combining several ultra-sensitive microscopy techniques into a single workstation completely new horizons for molecular biology related studies are opened. The aim of this combined ILM-AFM-OT setup is to look at the surface topography using high-resolution AFM, to study the distribution of cellular molecules using high sensitive fluorescence and contrast enhanced light microscopy (ILM), and to measure molecular interaction forces with ultra-sensitive optical tweezers. As a complementary method, photo-thermal nano-spectroscopy (PTNS) will be used to investigate spectroscopic properties of cellular material with a spatial resolution down to sub-100 nm which will enable chemical analysis of sub-cellular components. The combined setup will provide a qualitatively new level in microscopic studies, giving unprecedented versatility in the detection and monitoring of cellular events with highest spatial and temporal resolution. The proposed single workstation will be used for the study of the correlation between structure and function of living cells with applications in immunology and cancer research.",Single Molecule Workstation,FP7,30 November 2011,01 December 2008,2066150.0 SNAL,Rovira i Virgili University * Universitat Rovira i Virgili,health,"SNAL is a multidisciplinary programme specially designed to provide scientific and transferable skill training and career development for early stage researchers and experienced researchers in membrane research. Working in a multidisciplinary network will give the researchers a broad perspective on their research field as well as the basic ability of pursuing a research project from basic sciences to industrial applications. The broad aim is to train a new cohort of researchers with systemic thinking equipped with generic skills in combining experimental studies and computer simulations to prepare them for fruitful careers in academia and industry. One challenge for the project is the design and synthesis of novel biomaterials able to modify membrane properties. This requires deep understanding of the interactions of lipid membranes with nano-objects including functional biomimetic polymers, polymeric micelles, carbon nanotubes and polymer therapeutic complexes/conjugates to enable the intelligent design of novel materials with improved bilayer modifying properties. To achieve this goal we have assembled a highly interdisciplinary team of leading groups all having synergies in their established research interests in the field of lipid bilayer -nano-objects interactions. The project combines computer simulations, chemical synthesis, clinical and industrial expertise, physical and biological experiments. The industry involvement in the project is very high with full participation of Unilever and Biopharma, the companies from different sectors. Complementarity of partner skills provides a logical basis for a collective training programme. The full cycle of the design process, from theoretical models to synthesis and experimental and clinical validation, is of particular importance for training of ESRs and their future career development.",Smart Nano-objects for Alteration of Lipid-bilayers,FP7,31 March 2018,01 April 2014,3645408.0 SNAPSUN,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"Renewable energy production is a key driver for innovation in the material domain. Researchers and industries look to reduce the energy cost and to increase the efficiency of PV solar cells. Nanotechnologies and nanomaterials show broad opportunities. Indeed, at the nanoscale level, energy band gaps depend on nanomaterial architectures (nanoparticles size, bulk dispersion, interfaces with embedding matrix). Silicon nanocrystals allow the design of highly efficiency architectures, like multijunction solar cells or low-cost, optimised, thin film solar cells. The usual elaboration technique is based on the deposition of either multilayer or nanocomposite material in which excess silicon is aggregated into nanoparticles through high temperature annealing. No control of nanoparticle size and bulk dispersion is possible. Moreover, only limited surrounding materials could be considered (silicon containing). This prevents any knowledge-based tuning of the material properties. The main objective of SNAPSUN project is to develop a nanomaterial with reliable and tailored characteristics. To overcome limitations described above, fully tailored silicon nanoparticles will be optimised, in terms of size (3nm) and size dispersion (>10%;0.3nm). The SNAPSUN innovation is the incorporation of these silicon nanoparticles in a wide band gap material, such as silicon carbide or Transparent Conductive Oxides (TCO). This architecture will allow band gap engineering through accurate structure control, together with exceptional electrical characteristics (resistivity, carrier lifetime, etc.) in order to produce high conversion efficiencies above 25 %. Control of material structure will arise from the development of very promising processes allowing the separation of nanoparticle generation and embedding matrix codeposition. Vacuum and wet technologies will be used to target low-cost solar cells with a target production cost below 0.5 €/Wpeak.",Semiconductor Nanomaterial for Advanced Photovoltaic Solar cells Using New concept of nanocrystal and conductive host,FP7,31 May 2013,01 June 2010,2294535.0 SNB09,Technical University of Madrid * Universidad Politécnica de Madrid,energy,"The overall objective of the proposed project is the development of novel optoelectronic and photonic devices based on ordered arrays of GaN/AIGAN and InGaN/GaN nanorods. The mechanisms of spontaneous nucleation and growth of such nanorods on Si substrates, under specific experimental conditions, have been recently clarified and understood. However, the realization of true devices relies on the achievement of ordered arrays of nanorods by localization of the epitaxial growth on predetermined preferential sites. This challenging issue would be tackled by controlling the growth of such heterostructures by plasma-assisted molecular beam epitaxy (PA-MBE) growth on nanomasks and nanopatterned substrates, and by the subsequent processing of the nanodevices arrays. Ordered growth following a predefined pattern is a critical step to allow subsequent applications. Nanomasks and nanopatterning will be achieved by e-beam lithography and dry etching. Three different devices will be developed as demonstrators, namely, arrays of nanophotodetectors in the IR, white light nanoLEDs, and nanocolumnar Solar Cells. It is worth to remark that all these devices are beyond the state-of-the-art and will benefit from the very high and unique crystal quality of nanorods. Other advantages of such nanostructures are a wide absorption surface and the capability to exploit Photonic Crystal effects for light extraction. The objectives of this project, being very ambitious, are perfectly feasible because all devices are based on the same basic structure of nanorod arrays (building block). The project, aside from very relevant scientific aspects, will offer the young researcher a full training program on technological and complementary issues.","Substrate nanopatterning by e-beam lithography to growth ordered arrays of III-Nitride nanodetectors: application to IR detectors, emitters, and new Solar Cells",FP7,31 December 2012,01 January 2011,153917.0 SNCB,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),photonics,"This multidisciplinary proposal will utilize smart plasmonic concepts to solve intriguing biological and chemical problems. The plasmonic nanostructures will be arranged using biochemical linkers to provide sharp multipolar resonances which are highly sensitive to structural changes in space. The resulting plasmon rulers enable high-resolution plasmon spectroscopy and render possible optical detection of cellular activities and 3D dynamic behavior of bioentities. These smart plasmonic nanostructures will help to answer many profound questions in biochemistry that have eluded definite conclusions. These innovative concepts will pave the way towards a whole new era in research by bridging prosperous disciplines, plasmonics, physics, biology, and chemistry.",Smart Nanoplasmonics for Chemistry and Biology,FP7,28 February 2017,01 March 2013,100000.0 SNM,Technical University Ilmenau * Technische Universität Ilmenau,manufacturing,"To extend beyond existing limits in nanodevice fabrication, new and unconventional lithographic technologies are necessary to reach Single Nanometer Manufacturing (SNM) for novel ‘Beyond CMOS devices’. Two approaches are considered: scanning probe lithography (SPL) and focused electron beam induced processing (FEBIP). Our project tackles this challenge by employing SPL and FEBIP with novel small molecule resist materials. The goal is to work from slow direct-write methods to high speed step-and-repeat manufacturing by Nano Imprint Lithography (NIL), developing methods for precise generation, placement, metrology and integration of functional features at 3 - 5 nm by direct write and sub-10nm into a NIL-template. The project will first produce a SPL-tool prototype and will then develop and demonstrate an integrated process flow to establish proof-of-concept ‘Beyond CMOS devices’ employing developments in industrial manufacturing processes (NIL, plasma etching) and new materials (Graphene, MoS2). By the end of the project: (a) SNM technology will be used to demonstrate novel room temperature single electron and quantum effect devices; (b) a SNM technology platform will be demonstrated, showing an integrated process flow, based on SPL prototype tools, electron beam induced processing, and finally pattern transfer at industrial partner sites. An interdisciplinary team (7 Industry and 8 Research/University partners) from experienced scientists will be established to cover specific fields of expertise: chemical synthesis, scanning probe lithography, FEBIP-Litho, sub-3nm design and device fabrication, single nanometer etching, and Step-and-Repeat NIL- and novel alignment system design. The project coordinator is a University with great experience in nanostructuring and European project management where the executive board includes European industry leaders such as IBM, IMEC, EVG, and Oxford Instruments.",Single Nanometer Manufacturing for beyond CMOS devices,FP7,12 July 2018,01 January 2013,1.2012E7 SNO,National Hellenic Research Foundation * Ethniko Idryma Erevnon,health,"The main idea of the 'Science Night Out' proposal is to offer to the general public a night of going out and enjoying themselves with science. A common opinion that goes around when people are talking about science is that it is boring and somehow not relevant to their everyday life and personal interests. Researchers are though of as people with grey hair and white robes hiding inside their -if not secret then definitely isolated -laboratories working on subjects hardly understood by anyone else than themselves. On the other hand, people nowadays don't leave their home without their iphone and use at least once a day an internet application. Moreover, they are interested in anti-aging and find science fiction movies really cool. Isn't this an oxymoron of our times? Why iphone is great but nanotechnology seems frightening? It is because people don't connect them. People are using high tech gadgets in their every day lives ignoring their origin, are fascinated by the Milky Way pictures knowing nothing on radio astronomy and are looking forward to the latest anti-aging therapies but haven't heard of stem cells. What is missing here is the bond between the researchers and the general public. The aim of the 'Science Night Out' is to bring closer researchers and people from all different ages and backgrounds, let them know about the fascinating science hidden in their everyday lives and about the research going on in Europe, get them inspired of the latest scientific achievements, introduce them to real life researchers and academics and have them enjoy themselves and having a nice time while doing so.",Science Night Out,FP7,31 December 2012,01 June 2012,34299.0 SOAFNPCM,Autonomous University of Madrid * Universidad Autónoma de Madrid,health,"We plan to use supramolecular chemistry and self-assembly as a tool to organize p-conjugated molecules of the family of the phthalocyanines in a controlled way, in order to build well-defined, nanometer-sized functional objects. More concretely, we want to synthesize phthalocyanine-like molecules that are able to aggregate by p-p stacking interactions forming stable nanowires or nanoparticles. These assemblies are expected to have unprecedented physical properties, which will be studied both in solution and in the solid state, our final goal being the incorporation into nanoscale devices for organic photovoltaics, data storage or sensors that yield an enhanced performance and/or derive in novel potential applications.",Supramolecular Organization and Application of Functional Nanostructures of Phthalocyanine-like p-Conjugated Molecules,FP7,30 September 2011,01 October 2008,45000.0 SOCATHES,Eberhard Karls University of Tübingen * Eberhard Karls Universität Tübingen,information and communications technology,"Solid state physics and atomic physics have developed in a way that the combination of the two fields will produce massive synergetic effects and new physics. Thin film structures can be patterned and controlled down to the atomic level. Mesoscopic structures are used to create well defined two level systems and are presently explored in terms of their capability of being the basis of a quantum computer. The quantum dynamics of single electrons on a quantum dot or single Cooper pairs or flux quanta in case of superconductors can be controlled very well at temperatures in the Millikelvin range. Complementary, atomic physics has learned to control atoms and molecules almost perfectly and has turned to large ensembles of cold atoms forming e. g. Bose Einstein Condensates at low temperatures. In the present proposal we aim on the realization of such coupled solid state - atomic objects, starting with superconducting structures on the solid state side and with Rubidium atoms on the quantum optics side. We plan to investigate their fundamental properties and explore possible applications. In a second stage we consider including mechanical systems - nanoresonators - into our investigations. The heart of the experiments will be a ultra high vacuum millikelvin environment realized by a properly designed 3He-4He dilution refrigerator combined with a cold atom/BEC system. In terms of fundamental physics we will investigate the quantum nature of systems consisting of a macroscopic object like a flux quantum coherently coupled to a microscopic object like an atom. Combining solid state devices with atoms could lead to novel architectures in the field of quantum devices. In a similar spirit, ultrasensitive solid state detectors could be combined with atomic detection schemes, allowing for novel high precision measurement systems. We thus envision enormous potential for precision measurements and quantum engineered devices.",Solid State/Cold Atom Hybrid Quantum Devices,FP7,12 July 2015,01 January 2009,2344800.0 SOFC600,Energieonderzoek Centrum Nederland * Energy Research Centre of the Netherlands,energy,"The objective of this proposal for an Integrated Project is the development of stack components for the operation of SOFC systems at 600oC. Reducing the operating temperature to this level will have a great impact on lifetime and costs of SOFC system, thereby facilitating the commercial introduction of clean and efficient SOFC technology for combined heat and power generation in society, as well as auxiliary power for transport applications. The emphasis of the project is on the basic research and development of materials and processes for producing advanced stack components at low costs. The major components that the project works on are anodes, cathodes and electrolytes, as well as the integration of these components into cells. Furthermore, interconnect materials and contact materials will be evaluated and developed. For achieving the performance targets, nano-sized materials and electrode structures materials are considered essential and therefore the development of such materials is also addressed by the project. The significantly lower operating temperature compared to state-of-the-art SOFC technology enables the use of new sealing options for stacks, which will be developed in the project. Development will be aiming at components for hydrogen containing fuels (e.g. reformate compositions) and for internal reforming SOFC fuelled with natural gas. The validation of the technology developed will be by operation of short stacks.",Demonstration of SOFC stack technology for operation at 600C,FP6,28 February 2010,01 March 2006,6769923.0 SOFST,Huazhong University of Science and Technology,photonics,"The proposed knowledge transfer project on Smart Optical Fibre Sensor Technology (SOFST)via this International Incoming Fellowship (IIF) programme will bring the knowledge and expertise of the Marie Curie IIF Fellow Dr Qizhen Sun from the University of Huazhongin Chinawith the integration of the advanced optical fibre devicesfabrication technology and sensing applications of the EU host -Aston Institute of Photonic Technologies (AIPT) of Aston University to (1) develop advanced fibre grating and nano-micro structure based sensor platform; (2) explore speciality optical fibres for high function and multi-parameter sensors; (3) utilise functional nano and bio coating materials for sensor performance enhancement; (4) develop fibre laser based sensor systems for high resolution detection; (5) develop label-free on-line fibre sensor detection systems for food quality and security control. Together with proposed collaboration with 4 academic and 4 industrial co-hosts in Europe, the outcome of this project will not just enhance the EU leading position in smart fibre sensor technology but also the competiveness in commercialisation and wide range applications of this technology.",Knowledge Transfer of Smart Optical Fibre Sensor Technology,FP7,,,15000.0 SOFST,Aston University,photonics,"The proposed knowledge transfer project on Smart Optical Fibre Sensor Technology (SOFST)via this International Incoming Fellowship (IIF) programme will bring the knowledge and expertise of the Marie Curie IIF Fellow Dr Qizhen Sun from the University of Huazhongin Chinawith the integration of the advanced optical fibre devicesfabrication technology and sensing applications of the EU host -Aston Institute of Photonic Technologies (AIPT) of Aston University to (1) develop advanced fibre grating and nano-micro structure based sensor platform; (2) explore speciality optical fibres for high function and multi-parameter sensors; (3) utilise functional nano and bio coating materials for sensor performance enhancement; (4) develop fibre laser based sensor systems for high resolution detection; (5) develop label-free on-line fibre sensor detection systems for food quality and security control. Together with proposed collaboration with 4 academic and 4 industrial co-hosts in Europe, the outcome of this project will not just enhance the EU leading position in smart fibre sensor technology but also the competiveness in commercialisation and wide range applications of this technology.",Knowledge Transfer of Smart Optical Fibre Sensor Technology,FP7,05 March 2016,06 March 2014,231283.0 SOI-HITS,"Microsemi Semiconductors, Ltd.",information and communications technology,"SOI-HITS is an ambitious, innovative and timely STREP project that will enable significant energy consumption savings and reduce waste in processes such as: combustion in domestic boilers; oil & gas storage and transportation; CO2 capture and sequestration. It aims to deliver at least 15% saving of energy consumption in domestic boiler industry (~40 million domestic boilers in the EU with a growth rate of 15% per year); equating to 3.6 billion Euros saved per year. For this ambitious goal, SOI-HITS will develop innovative CMOS-compatible, Silicon-on-Insulator (SOI) integrated smart microsensor systems, capable of multi-measurand (water vapour, temperature, gas, flow, UV/IR) detection under harsh environment conditions (to 225oC, high water vapour level). SOI technology has several advantages over bulk silicon: enhanced electro-thermal isolation giving lower power consumption, ease of forming arrays of MEMS membranes, option of tungsten as a high temperature CMOS metal, direct integration of high-performance temperature and UV optical solid-state sensors. The smart multisensor chip will comprise multiple micro-hotplates with tungsten micro-heaters onto which selective nanostructured and thin film metal oxide sensing layers have been deposited. For the gas sensors (CO2 (concentration 6-10%, CO (0-1000ppm), and H2S (0-100ppm)), we will achieve fast thermal response time of a few ms and loss per micro-hotplate below 0.2mW/oC. Water vapour sensors, flow sensors (for liquid & gas) and precision on-chip temperature controllers will be also integrated. On-chip processing electronics, including drive circuitry, filters, amplifiers, processing circuits and analogue to digital interfaces, operating at 225oC, will be developed. The extension of the SOI platform to optical detectors, such as UV photodiode flame detectors and IR combined sources/detectors, will be explored. Finally development of a High Temperature SIP (system in a package) will enable real-world demonstrators.",Smart Silicon on Insulator Sensing Systems Operating at High Temperature,FP7,12 July 2016,09 January 2011,3025382.0 SOILARCHNAG,University of Abertay Dundee,environment,"A lack of understanding of the human and environmental health implications of nano-materials has deterred public and scientific support for nanotechnology evolution across industries. Nano-silver in particular has gained increasing popularity due to its biocidal properties in the garment industry to create odor-free clothing. An increase in “nano-litter” release to the environment is expected from erosion by product use and land application of nano-litter enriched wastewater sludge. This project will investigate the transport of nano-silver in soils through laboratory experiments using a novel 3-dimensional soil model technique that creates reproducible replicates of real soil pore networks, and simulations that combine non-equilibrium statistical physics of particle-solid interactions with information of Lattice-Boltzmann flow fields. The objectives are to: i) determine the effect that soil structure has on the transport of nanoparticles, ii) assess the capacity of soils under different land management practices (and therefore different soil architectures) to filter out suspended nano-litter from groundwater, and iii) develop a modeling tool to help industry forecast the propagation of nano-enabled products and their derivatives through soil environments from product use and disposal. The findings of this study are expected to directly impact environmental policy in the host country as well as worldwide.",EFFECT OF SOIL ARCHITECTURE ON TRANSPORT AND RETENTION OF SILVER NANO-LITTER,FP7,10 July 2016,11 January 2012,200371.8 SOILCY,Fundación Tekniker,environment,"Many times when a product, process or service is evaluated, the whole life cycle is not consistently consider, and although the unsustainability may be detected, no solutions are get in practice to promote a real sustainability. Part of the blame of this circumstance is due to the fact, that technical solutions, science developments and environmental measures do not go together. The aim of this integrated project is the optimisation of the new sustainable life cycle of an environmentally friendly, safe and human health compressor oil, taking into account all life phases and joining science, technology and environment disciplines, bringing to a less resources consuming and eco-efficient use industry. This approach includes the optimisation of initial life phases using glycerine from biodiesel as renewable resources and developing a clean production technology to transform it, in a polyglycerol esters derivate oil to be used in compressor applications. On the other hand, the optimisation will be completed taking into account a traditionally no consider phase, the use phase, by designing an innovative compressor device base on micro/nano-materials to replace harmful antioxidant additives and to lengthen the oil life making it more efficient.The new knowledge obtained from these activities will serve as input information to develop a ecoindicator based on biodegradability and toxicity measurements, which will fill the gap existing for a reliable environmental assessment of bio-lubricants.",NEW SUSTAINABLE COMPRESSOR OIL PRODUCTION AND USE. TOWARDS A LONG ECO-EFFICIENT LIFE CYCLE,FP6,28 February 2009,01 September 2005,4938697.0 SOLAMON,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The objective of the SOLAMON project is to develop high potential Plasmon Generating Nanocomposite Materials (PGNM) which will pave the way to the generation III solar cells (high efficiency & low cost). The objective is an augmentation in the External Quantum Efficiency resulting in an increase of 20% in the short circuit current density of the thin film solar cells. To achieve such an ambitious goal, the project will focus on the development of fully tailored building block nanoparticles able to generate a plasmon effect for enhanced solar absorption in thin film solar cells. Such nanoparticles designed for an optimum absorption will be integrated in solar cells matrix using a recently developed room temperature deposition process. This step will result in the specific design of PGNM for solar cells using a knowledge based approach coupling modeling at both scales: nanoscopic (plasmonic structure) and macroscopic (solar cells). SOLAMON will address three different classes of solar cells: a-Si:H thin films, organics and dye sensitised. Developing the PGNM on these three classes aims at maximizing the project impact and not to compare them because scientific background acquired on these technologies could be easily transferred to other ones. As a matter of fact, a-Si:H technology targets mainly the BuiIding Integrated PV (BIPV) market (large surfaces) whereas the two others are most suitable for the consumer good market (nomad applications). The project workprogram, the critical path and the contingencies plans are designed to maximize both social and economic impact. For this reason, the BIPV applications (i.e. a-Si:H based technology) will be firstly considered when a strategic choice occurs, keeping in mind that, even of large economic importance, the two other technologies do not have the same key BIPV environmental and social impact.",Plasmons Generating Nanocomposite Materials (PGNM) for 3rd Generation Thin Film Solar Cells,FP7,31 January 2011,01 February 2009,1599948.0 SOLAR BEYOND SILICON,University of Cambridge,energy,"This project aims to combine two recent breakthroughs in solution-processed thin-film solar photovoltaics (PVs) to demonstrate a low-cost, stable PV device with an efficiency approaching conventional crystalline silicon devices. The aim will be achieved by integrating singlet fission, a process capable of pushing PV efficiencies beyond conventional limits, with recent exciting perovskite results. The researcher is uniquely suited to this ambitious project, which will engage him with world-leading techniques, collaborations, and transferrable skills and help him to achieve his goal of establishing a leading UK-based device spectroscopy research group. The project comprises an outgoing phase in Prof. Valdimir Bulovic's Organic & Nanostructured Electronics Group at the Massachusetts Institute of Technology, where their unrivalled expertise in the deposition and nanopatterning of materials will be applied to perovskite/singlet fission devices. This expertise will be transferred back to Prof. Sir Richard Friend's Optoelectronics (OE) Group at Cambridge University, world-leaders in ultrafast spectroscopy. Device behaviour will be elucidated and performance optimised by studying ultrafast phenomena such as the dynamics and mechanism of charge generation. Such a partnership of high-end nanoengineering and ultrafast spectroscopy is yet to be achieved and is likely to lead to revolutionary breakthroughs. The work will ensure that state-of-the-art expertise not currently available in the European Research Area (ERA) is transferred to the European community. This will create strong international links between the two leading groups, with enormous potential for intellectual property generation and industry involvement through OE Group spin-outs and partners and knowledge transfer from interaction with successful enterprises in the Boston area. This will increase Europe's competitiveness in the solar energy sector and ensure its energy security and emission targets are reached.",Nanoengineering High-Performance Low-Cost Perovskite Solar Cells Utilising Singlet Fission Materials,FP7,,,294219.0 SOLAR BIO-HYDROGEN,University of Oxford,energy,"The need to establish renewable energy supplies, both as a strategic economic requirement and as a wedge against climate change is leading organizations to invest in research on capturing solar energy. There is particular interest in artificial photosynthesis, using photons to produce electricity or fuels using a man-made device rather than a plant. In natural in-vitro system for hydrogen production, complex molecule i.e. chlorophyll harvest solar energy and subsequent electronic excitation leads to ejection of electrons from the chlorophyll dimer and then passed on to various electron-transferring mediators. This electron donor system may be replaced with the visible light sensitized inorganic photocatalyst. At present, the photocatalysts that have been synthesized and tested fall far short of the efficiency and catalytic rates of enzymes that catalyze either H2 production (hydrogenases) or O2 production (the Mn cofactor of Photosystem II). Therefore the enzymes themselves represent important benchmarks for gauging the possibilities for building water-splitting photocatalysts from inorganic and organic photophysical materials. In such devices enzyme molecules are linked to the semiconductor surface in such a way that they are stable and electrocatalytically active. Therefore, the proposed project is focused on the fabrication of chalcogenide semiconducting nanostructures (mainly nanotubes / nanowire / gyroid having few nm thick wall) and grafting of redox proteins onto these nanostructures for their subsequent exploitation in photoelectrochemical hydrogen production. The exploration of the photoelectrochemistry involved and properties of enzymes which govern the hydrogen generation will also be undertaken. In addition, various other parameters such as the electrolyte pH, nature of sacrificial reagents, combination of chalcogenide photocatalyst- redox proteins (eg. Hydrogenase etc.) will be optimized to maximize solar hydrogen production efficiency.",Design of Hybrid Nanostructured Bio-photocatalyst for Their Application in Bio-photoelectrochemical Hydrogen Production,FP7,31 August 2012,01 September 2010,181103.0 SOLAR-PLUS,University College London,health,"Maximizing the Efficiency of Luminescent SOLAR Concentrators by Implanting Resonant PLASmonic Nanostructures(SOLAR-PLUS) is a four-year interdisciplinary research project in optical electromagnetic modeling, material engineering and nanotechnology fabrication, whose aim is to reduce the cost of harvesting solar energy by exploiting advanced nanophotonic concepts. The main technical objective of the proposed work is to double the energy conversion efficiency of a typical monolayer luminescent solar concentrator (LSC) system, currently standing at <4% to >8%, by harnessing the interplay phenomena between fluorescence and localized surface Plasmon resonances. The deliverables of the project are: i) To understand the fundamental interactions between plasmonics and fluorescent molecules and through the gained physical insight to derive a set of design rules for metallic nanoparticles tailored to LSC applications, ii) to develop a generic simulation platform that combines nanoscale and macroscale modeling, to allow for rapid prototype performance assessment before proceeding to expensive fabrication, iii) to fabricate highly efficient prototype plasmonic-LSCs and, iv) to explore completely new research avenues that can bring about radical improvements to LSC efficiency. Improving the energy conversion efficiency of LSCs and reducing their cost are important steps towards the commercial viability of this technology, which will assist in the EUs efforts to limit its dependence on fosil fuels. In addition, the project will serve to ensure the long term professional stability of the fellow by assisting him in securing a permanent position in the department of Electrical and Electronic Engineering at University College London.",Maximizing the Efficiency of Luminescent Solar Concentrators by Implanting Resonant Plasmonic Nanostructures (SOLAR-PLUS),FP7,31 August 2015,01 September 2011,100000.0 SOLARIN,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),energy,"The target of this project is the establishment of a technology platform for the fabrication of a new generation of multi-junction photovoltaic cells based on nanostructured InGaN layers synthesized on silicon substrates. Currently, the photovoltaic market is dominated by single-junction crystalline silicon modules because of their low cost and long-term reliability. However, higher conversion efficiencies are obtained using advanced multi-junction techniques operating under concentration. In this context, this project aims at a major break-through in the solar domain by introduction of InGaN-on-Si solar cells. The ultimate objective is to implement a tandem cell with an InGaN junction in series with a silicon solar cell, in order to achieve a photovoltaic device with high conversion efficiency at a moderate production cost. Furthermore, the outstanding physical and chemical stability of III-nitrides enables them to operate in harsh environments, showing high stability under concentration conditions and superior resistance to high-energy particle radiation. We propose a completely new approach to the nitride-based solar cell, addressing directly nitrogen-polar high-In content layers on low-cost Si(111) substrates. The project must face a number of technological challenges: new state-of-the-art for nitride material design, growth and fabrication technology adapted to the InGaN specificities. As relevant novelties, three novel approaches are incorporated into the solar cells design: (i) growth of N-polar material by introducing a new concept of 3D buffer layer to improve the carrier collection, (ii) incorporation of InGaN/GaN nanostructures (quantum wells/dots) in the active region to enhance indium incorporation, facilitate the strain management and increase the spectral response in the infrared spectral range, and (iii) incorporation of heterostructured p-type region.",Solar cells based on InGaN nanostructures on silicon,FP7,10 March 2015,11 March 2013,194046.0 SOLHYCARB,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),energy,"The SOLHYCARB proposal addresses the exploration of an unconventional route for potentially cost effective hydrogen production with concentrated solar energy. The novel process thermally decomposes natural gas (NG) in a high temperature solar chemical reactor. This process results in two products: a H2-rich gas and a high-value nano-material, Carbon Black (CB). H2 and marketable CB are thus produced with renewable energy. Solar energy is stored as a transportable fuel. The fuel has zero CO2 emission: carbon as opposed to CO2 is sequestered, and fossil fuels are saved. Potential impacts on CO2 emission reduction and energy saving are respectively: 14 kg CO2 avoided and 277 MJ per kg H2 produced, with respect to conventional NG steam reforming and CB processing. The proposal aims at designing, constructing, and testing innovative solar reactors at different scales (1-10 kW and 50 kW) for operating conditions at 1500-2300 K and 1 bar. First, two prototypes based on different concepts of solar receiver/reactor (direct and indirect heating concepts) will be developed and studied. A critical analysis of the results from experiments and modelling will determine the best reactor concept suitable for solar methane splitting. Based on the concept retained, a 50 kW power pilot reactor will be developed. The targeted results are: methane conversion over 80%, H2 yield in the off-gas over 75%, and CB properties equivalent to industrial products. This experimental work is highly combined with advanced reactor modelling, study of separation unit operations, industrial uses of the produced gas, and determination of CB properties for applications in batteries and polymers. Decentralized and centralized commercial solar chemical plants (and hybrid plants) will be designed for 50/100 kWth and 10/30 MWth. Projected cost of H2 for large-scale solar plants depends on the price of CB: 14 Euros/GJ for the lowest CB grade sold at 0.66 Euros/kg and decreasing to 10 E/GJ for CB at 0.8 E/kg",Hydrogen from Solar Thermal Energy: High Temperature Solar Chemical Reactor for Co-production of hydrogen and carbon black from natural gas cracking,FP6,28 February 2010,01 March 2006,1997300.0 SOLHYDROMICS,Polytechnic University of Turin * Politecnico di Torino,energy,"Leaves can split water into oxygen and hydrogen at ambient conditions exploiting sun light. Prof. James Barber, one of the key players of SOLHYDROMICS, was the recipient of the international Italgas Prize in 2005 for his studies on Photosystem II (PSII), the enzyme that governs this process. In photosynthesis, H2 is used to reduce CO2 and give rise to the various organic compounds needed by the organisms or even oily compounds which can be used as fuels. However, a specific enzyme, hydrogenase, may lead to non-negligible H2 formation even within natural systems under given operating conditions. Building on this knowledge, and on the convergence of the work of the physics, materials scientists, biochemists and biologists involved in the project, an artificial device will be developed to convert sun energy into H2 with 10% efficiency by water splitting at ambient temperature, including: -) an electrode exposed to sunlight carrying PSII or a PSII-like chemical mimic deposited upon a suitable electrode -) a membrane enabling transport of both electrons and protons via e.g. carbon nanotubes or TiO2 connecting the two electrodes and ion-exchange resins like e.g. Nafion, respectively -) a cathode carrying the hydrogenase enzyme or an artificial hydrogenase catalyst in order to recombine protons and electrons into pure molecular hydrogen at the opposite side of the membrane The project involves a strong and partnership hosting highly ranked scientists (from the Imperial College London, the Politecnico di Torino and the GKSS research centre on polymers in Geesthacht) who have a significant past cooperation record and four high-tech SMEs (Solaronix, Biodiversity, Nanocyl and Hysytech) to cover with expertise and no overlappings the key tasks of enzyme purification and enzyme mimics development, enzyme stabilisation on the electrodes, membrane development, design and manufacturing of the SOLHYDROMICS proof-of-concept prototype, market and technology implementation studies",Nanodesigned electrochemical converter of solar energy into hydrogen hosting natural enzymes or their mimics,FP7,30 June 2012,01 January 2009,2779679.0 SOLICOAPS,University of Bristol,energy,"Major interest exists and research activities have grown over the last decade to investigate the development of renewable energies generated from natural sources, especially in the area of solar cells (or photovoltaics, PV), a high priority area of research in the European Research Area (ERA). Central to addressing this challenge is the development of novel materials with tunable optoelectronic properties. However, one class of materials that has received almost no attention at all is the aniline-based materials (polyaniline and its lower oligomers). The proposed research focuses on the design and synthesis of Self-Organising Liquid-Crystalline OligoAnilines for Photovoltaic Applications, making use of newly developed synthetic approaches to produce such tunable materials. Several series of oligomers with new architectures, liquid-crystalline properties and varied conjugation architectures and lengths will be produced. These will be characteristed and combined with suitable inorganic semiconductors. The nanoscale morphology of such photoactive blends will be optmised, and utilised to produce proof-of-concept photovoltaic devices. This research will open unexplored avenues through its interdisciplinary and multidisciplinary approach, i.e., it will rely on modern synthetic organic chemistry, chemicophysical analyses of optoelectronic properties, morphologies and structure relationships, self-assembly in the solid state, device fabrication and testing. It is expected that the research and training outcomes of this proposed research will impact across the mentioned range of disciplines, and contribute highly trained researchers and knowledge to a high priority area for both society and research within the EU as well as on an international level.",Self-Organising Liquid-Crystalline OligoAnilines for Photovoltaic Applications,FP7,02 May 2013,03 May 2011,208592.0 SOLID,Chalmers University of Technology * Chalmers Tekniska Högskola,photonics,"The SOLID concept is to develop small solid-state hybrid systems capable of performing elementary processing and communication of quantum information. This involves design, fabrication and investigation of combinations of qubits, oscillators, cavities, and transmission lines, creating hybrid devices interfacing different types of qubits for quantum data storage, qubit interconversion, and communication. The SOLID main idea is to implement small solid-state pure and hybrid QIP systems on common platforms based on fixed or tunable microwave cavities and optical nanophotonic cavities. Various types of solid-state qubits will be connected to these "hubs": Josephson junction circuits, quantum dots and NV centres in diamond. The approach can immediately be extended to connecting different types of solid-state qubits in hybrid devices, opening up new avenues for processing, storage and communication. The SOLID objectives are to design, fabricate, characterise, combine, and operate solid-state quantum-coherent registers with 3-8 qubits. Major SOLID challenges involve: Scalability of quantum registers; Implementation and scalability of hybrid devices; Design and implementation of quantum interfaces; Control of quantum states; High-fidelity readout of quantum information; Implementation of algorithms and protocols. The SOLID software goal is to achieve maximal use of the available hardware for universal gate operation, control of multi-qubit entanglement, benchmark algorithms and protocols, implementation of teleportation and elementary error correction, and testing of elementary control via quantum feedback. An important SOLID goal is also to create opportunities for application-oriented research through the increased reliability, scalability and interconnection of components. The SOLID applied objectives are to develop the solid-state core-technologies: Microwave engineering; Photonics; Materials science; Control of the dynamics of small, entangled quantum systems",Solid State Systems for Quantum Information Processing,FP7,30 September 2013,01 February 2010,5412000.0 SOLPROCEL,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),energy,"The triggering of SOLPROCEL took place when COMSA EMTE and ICFO realized the potential that an organic photovoltaic (OPV) based technology has to be incorporated in transparent modules to generate electricity. Indeed, the OPV technology is the only one capable of producing semitransparent colorless cells providing a clear and undistorted image when looking through the device. It can be perfectly integrated in buildings façades offering an enormous potential for electricity production units to penetrate in urban areas. However, COMSA EMTE is well aware that transparent OPV cells are not yet ready for a module production phase and priority must be given to material research. Several issues, spanning from the development of low cost module fabrication to having stable and durable devices, must be addressed. Much of the success rests on having the materials for such low cost module fabrication. To achieve an optimal light harvesting in a solution-processed semitransparent OPV cell, we propose to combine the device processing developed by FAU with the photonic control developed by ICFO. Encouraged by COMSA EMTE and FAU, ICFO took the lead of SOLPROCEL. The project incorporates 3 companies which will be able to industrially produce the PV and nano materials needed in solution-processed OPV cells: Specific Polymers the PV polymers, Nanograde the nanoparticles used in the buffer layers, and RAS the Ag nanowires used in the electrodes. In SOLPROCEL such companies will be guided by three research institutions which can provide complementary knowhow in three of the fundamental aspects of OPV technology: nano-fabrication (FAU), light management (ICFO), and organic synthesis (FhG-IAP). The quantifiable goal of SOLPROCEL is to obtain the materials needed for fully solution-processed high performance transparent OPV cells and to raise the efficiency of such cells from 5.6% to 9%. This later value corresponding to 80% of the 12% efficiency of the corresponding opaque cell.",SOLUTION PROCESSED HIGH PERFORMANCE TRANSPARENT ORGANIC PHOTOVOLTAIC CELLS,FP7,31 October 2016,01 November 2013,2860434.0 SOLVER,Flemish Institute for Technological Research * Vlaamse Instelling voor Technologisch Onderzoek (VITO),health,"Solvents are widely used in process industries such as chemical, petrochemical, pharmaceutical, food, biotechnology and microelectronics. The recovery of spent solvents containing all types of impurities presents a vast market, targeting thousands of small to medium sized companies in Europe that are generating highly as well as marginally polluted solvent streams. Many current solvent purification and manufacturing practices utilise a traditional, energy-intensive distillation-based technology in the production and/or recovery of liquid chemicals. This method of processing is costly, inefficient and produces a significant volume of hazardous waste. This project, SOLVER, proposes to debottleneck the heating step as well as the thermal chemical reactions involved, and replace them with membrane separation techniques working at room temperatures and able to achieve separations at the molecular level, i.e. pervaporation (PV) and organic solvent nanofiltration (OSN). Such chemical process intensification in solvent recovery and purification is expected to lead to significant improvements in product cost, materials usage, energy and waste reduction, as well as a decrease in risk and hazards. Thanks to the interdisciplinary and complementary skills of the consortium members, SOLVER aims at demonstrating the potential of OSN/PV technology in solvent manufacturing through lab-scale and pilot testing, but also at more fundamentally understanding the processes and the behavior of the membranes during filtration. The latter will be pursued by advanced characterization and on-line process monitoring tools. SOLVER joins two types of innovative SME end-users building out new business lines to stay ahead of competition. Two SMEs are active in solvent recycling/manufacturing, the other two in OSN/PV membrane production. The SME partners form a strategic supply chain and are expected to continue to leverage on the technological head-start after the project, take the results of the RTD work directly to the market, find new applications for their products, and be the market leaders in their respective sectors.",Solvent purification and recycling in the process industry using innovative membrane technology,FP7,01 December 2012,02 December 2010,658734.0 SOMABAT,Technological Institute of Energy * Instituto Tecnológico de la Energía,energy,"SOMABAT aims to develop more environmental friendly, safer and better performing high power Li polymer battery by the development of novel breakthrough recyclable solid materials to be used as anode, cathode and solid polymer electrolyte, new alternatives to recycle the different components of the battery and cycle life analysis. This challenge will be achieved by using new low-cost synthesis and processing methods in which it is possible to tailor the different properties of the materials. Development of different novel synthetic and recyclable materials based carbon based hybrid materials, novel LiFePO4 and LiFeMnPO4 based nanocomposite cathode with a conductive polymers or carbons, and highly conductive electrolyte membranes with porous architecture based on fluorinated matrices with nanosized particles and others based on a series of polyphosphates and polyphosphonates polymers will respond to the very ambitious challenge of adequate energy density, lifetime and safety. An assessment and test of the potential recyclability and revalorisation of the battery components developed and life cycle assessment of the cell will allow the development of a more environmental friendly Li polymer battery in which a 50 % weight of the battery will be recyclable and a reduction of the final cost of the battery up to 150 €/KWh. The consortium has made up with experts in the field and complementary in terms of R&D expertise and geographic distribution.",Development of novel SOlid MAterials for high power Li polymer BATteries (SOMABAT). Recyclability of components.,FP7,31 December 2013,01 January 2011,3700896.0 SOMAGNANOSURF,Paris Diderot University * Université Paris Diderot - Paris 7,information and communications technology,"The objective of the project is the elaboration of new magnetic nanostructures and the investigation of their magnetic properties. These magnetic nanostructures will be elaborated in the 'bottom-up" approach. Once developed the original nanostructures, we will perform in-situ the investigation of their magnetic properties (reversal of magnetization, superparamagnetism an interactions). The control of the epitaxial growth under ultra-high vacuum conditions will allow the fabrication of new kinds of nanostructures. Two methods will be used to achieve this goal: self organisation and co-adsorption of two immiscible metals in volume. In the self-organisation approach, the host group has the experience of previous work during the last ten years. Nanostructures with macroscopic order architecture will be created. Current systems wil te Co and Fe nanostructures grown on templates such as Au(l 11) vicinais or Pt(l 11) vicinais. We wil explore the combination of step arrays with dislocations networks since the pioneering system of Co/Au(788) has already revealed promising results. The second approach to develop nanostructures will be the co-adsorption of two immiscible metals in volume under surface stresses induced by the substrate. This happens when the adsorbed metals have a bulk lattice parameter respectively smaller and larger than the one of the substrate. Systems such as Co and Ag on Ru or Rh substrates will be studied. This will also provide supported dilute magnetic systems interesting for nanomagnetism. After the development of the nanostructures, we will focus on their magnetic properties. We will study the energetic barrier for magnetisation reversal of one particle versus the size of the particle, which is still a challenging question in such small magnetic nanostructures. We will also study other magnetic properties that are essential in information storage and/or in spin electronics, like magnetic anisotropy, and magnetisation flipping processes.",Self-organised Magnetic Nanostructures Supported on Crystalline Surfaces,FP6,31 December 2005,01 January 2004,158786.0 SOMATAI,Juelich Research Centre * Forschungszentrum Jülich,environment,"Soft nanotechnology is generally considered as a field that will have a major impact on technological developments in near future. However, the fundamental understanding of the wealth of new structures lacks far behind, despite supporting activity from material science. Such an understanding is indispensable for sustainable growth of this important research domain and its applications. A physics-oriented interdisciplinary education is urgently needed to guide young researchers to the point where they can tackle the relevant fundamental questions. SOMATAI is set up to provide just such training by combining two distinct scientific fields: Soft matter science is a well established interdisciplinary field for the bulk investigation of polymers, colloids, and liquid crystals with response amplitude and time to external stimuli as a function of soft matter structure being of special interest. The second highly relevant field is interface science, since nano-structured materials contain a huge area of internal interfaces which have an essential impact on material properties. The application of the soft matter approach to interfaces promises new and deeper understanding of interfacial phenomena. Interfaces of a water phase to a solid, liquid or gaseous second phase are of special interest and a focal point of SOMATAI. Such interfaces are highly relevant to products from European industry (food, cosmetics, paints) and processes (washing, coating, water purification). They have an outstanding importance from a scientific point of view due to specific interactions at such interfaces. This carefully planned teaching and research programme in a network of 10 leading academic partners, 1 large scale companies, 2 SMEs, and 4 top-level associated partners from Germany, Taiwan and the USA will ensure that young researchers are given an excellent training in a pioneering research domain of high scientific and technological relevance, where Europe can take a leading position.",Soft Matter at Aqueous Interfaces,FP7,09 June 2018,10 January 2012,3562776.87 SONO,Bar-Ilan University,health,"Hospital-acquired (nosocomial) infections are a major financial issue in the European healthcare system. The financial impact of these infections counteract medical advances and expensive medical treatments by increasing the length of hospital stay by at least 8 days on average per affected patient, hence adding more than 10 millions patient days in hospitals in Europe per year. The statistics on patient safety in the EU show alarming tendencies : - 1 in 10 patients are affected by hospital-acquired infections - 3 million deaths are caused by hospital-acquired infections An active infection control program of patients and personnel and hygiene measures, have proven to significantly reduce both the number of infections and hospitalisation costs . The SONO project directly addresses the above problems by developing a pilot line for the production of medical antibacterial textiles. The pilot line will be based on the scale-up of a sonochemical process developed and patented at BIU laboratories. The pilot line will use a sonochemical technique to produce and deposit inorganic, antimicrobial nanoparticles on medical textiles, e.g. hospital sheets, medical coats and bandages. Sonicators are used industrially for heavy and light duty cleaning, for water disinfection and for sewage treatment. It is also used in the food industry for emulsification and drying. The proposed concept based on one step sonochemical process to produce nanoparticles and impregnate them as antibacterial factors on textile is novel and does not exist on an industrial scale. The concept has already been proven (and patented ) on a lab scale where sonochemistry was applied to impregnate nanoparticles in a single-step process. It was demonstrated that due to the special properties of the sonochemical method the antibacterial nanoparticles are adsorbed permanently on the fibres even after 70 'laundry cycles'. The sonochemical impregnation process is a one-step procedure in which the nanopa",A pilot line of antibacterial and antifungal medical textiles based on a sonochemical process,FP7,30 September 2013,01 October 2009,8300000.0 SONO ENGINEERING,University of Liverpool,energy,"This research aims to harness ultrasonication as innovative thermal treatment tool to effectively engineer the electronic structures of colloidal particles. The main objectives of this project are: 1) to develop various interfacial strategies to establish a general and innovative low cost ultrasonication based thermal treatment protocol; 2) to gain novel and effective sono-engineering methodologies for introducing intrinsic/extrinsic defects in seminconductor nanoparticles; and 3) to acquire innovatively enhanced photovoltaic behaviors of from the sono-engineered semiconductor nanostructures. The anticipated thermal treatment will be easy, cheap, easily accessible, and feasible for massive production in comparison with conventional black-body-radiation-based thermal treatment. This will enable one to gain in-depth insight to the physics of acoustic bubbles and especially the energy release during bubble collapse and to effectively transform existing semiconductor particles to be photovoltaic and photoelectrochemical more active for efficient storage and conversion of solar energy and exploitation, thus making a significant step forwards in solar energy exploitation. The proposed project is a multidisciplinary one, and the results of the project can be of great interest for scientists and engineers from diverse areas including colloids and interface science, material science, nanotechnology, condensed matter physics, sonochemistry, electrochemisty and photovoltaics. According to the project objectives, the proposed project contributes to the 'Nanosciences, Nanotechnologies, Materials and new Production Technologies (NMP)', one of the themes of the 7th European Framework Cooperation Programme. Successfully carrying out of this project will result in significant economic, environmental and strategic impact to energy industry and our sustainable society.",Electronic Structures Sono-Engineering of Semiconductor Nanoparticles for Efficient Solar Energy Exploitation,FP7,30 September 2016,01 October 2014,231283.0 SONODRUGS,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,health,"The demographic changes in Europe towards an aging society will coincide with increasing morbidity of the population. European citizens need improved access to state-of-the-art medical care especially in oncology and cardiology, while keeping expenditures on healthcare affordable. New therapeutic options such as externally triggered local drug release at the diseased area hold promise to solve urgent medical needs: improved treatment with reduced side effects, fewer burdens to the patient and faster recovery after intervention. Nanomedicine, the application of nanomaterials and nanotechnology to healthcare, will enable breakthroughs in clinical practice. SONODRUGS addresses clinical needs by developing novel drug delivery technologies for localised treatment of cardiovascular disease and cancer. SONODRUGS develops drug delivery concepts where drug release can be triggered by focused ultrasound induced pressure or temperature stimuli within the diseased tissue. New drug loaded nanocarriers will be designed for tailored drug delivery systems that respond to either of the two stimuli. Medical imaging, i.e. magnetic resonance imaging and ultrasound imaging, will be used to guide, follow and quantify the drug delivery process. Therapy efficacy using different drug delivery systems will be assessed in vitro and subsequently in preclinical studies. Starting form research on a broad range of materials and drugs, two nanocarriers will be finally selected, optimized and produced on a pilot scale in combination with image-guided delivery tools and methods. SONODRUGS binds expertise in materials research (Philips, TUE, GhentRGN, HBBG); material production (Nanobiotix, Lipoid); clinical knowledge in oncology (UTours, HBBG) and cardiology (UKB); in vitro and preclinical validation (UTours, ErasmusMC, UKB); research on imaging techniques (UCY, Philips, IMF); pharmacokinetics, toxicology and biodistribution (ULSOP, IPT).",Image-controlled Ultrasound-induced Drug Delivery,FP7,31 October 2012,01 November 2008,1.07839E7 SOUND PHARMA,UNIVERSITAIR MEDISCH CENTRUM UTRECHT * UNIVERSITY MEDICAL CENTER UTRECHT,health,"The principal objective of the Sound Pharma project is to increase the therapeutic index of potent, often toxic treatments through personalized image-guided treatment, which ultimately decreases adverse effects of drugs by better controlling the pharmacokinetics (PK) and pharmacodynamics (PD) of therapy. For local disease, exogenous energy will be used to to release drugs entrapped within nanoparticles circulating through the tumor. This will be achieved via a combination of Focused Ultrasound, and drug nanocarriers that are sensitive to bio-effects of ultrasound. The drug ¿magic bullet¿ is at the heart of Pharma¿s business model. However, targeted drug delivery is increasingly being recognized as a key limiting factor of drug efficacy. Nanotechnologies are providing new formulations as well as novel methods for targeting. The combination of nanotechnologies and external triggering will provide novel technologies to achieve spatio-temporal control of drug delivery. The effect of ultrasound in tissue allows the local deposition of drugs from nanocarriers circulating in the blood, and/or their local activation. This is the case when using nanocarriers sensitive to mechanical forces and/or to small temperature elevations. Extravasation and membrane permeability are also enhanced by ultrasound. This new field of Image Guided Drug Delivery opens up opportunities for Pharma to expand applications for their existing small drugs (e.g. doxorubicin, cisplatin, irinitecan) in cancer by altered pharmacokinetics. This project intends to develop new focused ultrasound methods for drug delivery, based on local control of temperature and pressure, and by monitoring and validating intracellular uptake in real time using optical and MRI methods. The developed FUS methods will be applied to treatment of liver cancer using nanocarriers containing well known chemotherapeutica, via animal models, as well as in the clinic.",Image Guided Local Drug Delivery from Nanocarriers using Focused Ultrasound,FP7,30 November 2016,01 December 2011,2500000.0 SOWAEUMED,Autonomous University of Barcelona * Universitat Autònoma de Barcelona,environment,"The project foresees the synergic work of participants of various scientific profiles by improvement of scientific relationships, exchange of know-how and experience between the participating centres, including training in MS of Ph.D. students and/or post-doctoral researchers, to upgrade S&T research capacities of centres in MED countries dealing with waste treatment technologies both conventional, advanced and nanoscience based. The proposal includes one SME (Environmental Engineering) in order to give to the project a complementary and applied - business dimension. To be able to participate in the project on an equal-footing basis, the different technological developments of the groups should be balanced by reinforcement of MED countries research infrastructure and improvement of their human potential. This will be achieved by upgrading research equipment in the laboratories of less developed countries and by hiring new senior researchers in these groups. Thus, the transfer and exchange of know-how will be accelerated and the potential of the groups can be better exploited. This approach will prepare laboratories from MED countries to participate more efficiently in European projects. Moreover, it will enable MED countries to increase their contribution in the ERA, making them interesting partners to scientists from MS.",NETWORK IN SOLID WASTE AND WATER TREATMENT BETWEEN EUROPE AND MEDITERRANEAN COUNTRIES,FP7,11 June 2014,12 January 2009,881856.52 SPAJORANA,University of Linz * Johannes Kepler Universität Linz,health,"A renewed interest in Ge has been sparked by the prospects of exploiting its lower effective mass and higher hole mobility to improve the performance of transistors. Ge emerges also as a promising material in the field of spin qubits, as its coherence times are expected to be very long. Finally, it has been proposed that strained Ge nanowires show an unusually large spin orbit interaction, making them thus suitable for the realization of Majorana fermions. In view of these facts, one is able to envision a new era of Ge in information technology. The growth of Ge nanocrystals on Si was reported for the first time in 1990. This created great expectations that such structures could provide a valid route towards innovative, scalable and CMOS-compatible nanodevices. Two decades later the PI was able to realize the first devices based on such structures. His results show that Ge self-assembled quantum dots display a unique combination of electronic properties, i.e. low hyperfine interaction, strong and tunable spin-orbit coupling and spin selective tunneling. In 2012, the PI's group went a step further and realized for the first time Ge nanowires monolithically integrated on Si substrates, which will allow the PI to move towards double quantum dots and Majorana fermions. In view of their exceptionally small cross section, these Ge wires hold promise for the realization of hole systems with exotic properties. Within this project, these new wires will be investigated, both as spin as well as topological qubits. The objective of the present proposal is mainly to: a) study spin-injection by means of normal and superconducting contacts, b) study the characteristic time scales for spin dynamics and move towards electrical spin manipulation of holes, c) observe Majorana fermions in a p-type system. The PI's vision is to couple spin and topological qubits in one 'technological platform' enabling thus the coherent transfer of quantum information between them.",Towards spin qubits and Majorana fermions in Germanium self-assembled hut-wires,FP7,31 December 2018,01 January 2014,1675020.0 SPAM,ASML Netherlands BV,manufacturing,"Today, markets demand smaller, cheaper, energy friendly and more different consumer products. Last decades micro technology has opened possibilities for mobile communication, safety and health science products. To meet these demands, the industry is encountering technological barriers that prevent the industry from evolving from the micro to a nanotechnology era. To resolve these barriers, the industry and research institutes need to initiate research programmes, and need to structure and integrate its research programmes and transfer the knowledge that as been acquired in these programmes. “New†researchers have to be trained with excellent research skills, knowledge on the specific technology, and understanding of market demands, application development, and so on. For this purpose 4 industrial, 5 academic and 3 research institutes have defined the 4 year SPAM research and training program; “a Supra-disciplinary approach to research and training in surface Physics for Advanced Manufacturing - SPAMâ€. Research objectives are: • identify and develop crucial knowledge in the field of surface physics, • enable the manufacturing of smaller semi-conductors and hence technology to print under 32 nm; extreme positional accuracy (< 4 nm); at competitive cost, • use this knowledge to further develop lithography technologies/tools needed for cost efficient development of nano-electronic devices, including manufacturing processes. Training objectives are: • provide personalised individual training, in particular for 16 ESR but also for 6 ER, to prepare and optimise their research in SRTs, with the help of 9 VS. • provide a network-wide training, fully exploiting the network potential and complementarities, leading to 12 network events. • transfer existing knowledge between partners through the SRTs and to transfer newly gained knowledge. Meeting the objectives are the responsibility of 4 Supra-disciplinary Research Teams (SRT) and 5 interlinking Training Exchange Pools.",Surface Physics for Advanced Manufacturing,FP7,09 June 2014,10 January 2008,4300696.82 SPANAMICO,University of Western Australia,environment,"The activity of microorganisms in soil is regulated by soil-water-oxygen interactions, the availability of a habitable space and a food source. The relationship between the spatial location of microorganisms in soil and the actual physical structure of the soil has a major influence on nitrogen (N) cycling processes. However, to date the international research community knows very little about the interactions between soil physics and soil biology. This is because of a prior lack of sensitive techniques and equipment to apply to this emerging field of research. However, this is now possible with use of the latest technology available in microscopy, stable isotopes and molecular techniques. This can be achieved through collaborative research between the University of Newcastle upon Tyne (United Kingdom) and the University of Western Australia (UWA). The recent acquisition of the nano-Secondary Ion Mass Spectrometer at UWA (one of only 10 in the world) which links high-resolution microscopy to N isotope analysis provides the previously missing piece of the jigsaw in this proposed research. This means that the Marie Curie Fellow will be at the forefront of this emerging field of soil research. The aim of SPANAMICO is therefore to improve our understanding of how the soils 3-Dimensional (3-D) chemical and physical matrix regulates the cycling of N within the soil and from the soil to water and air. The main objective is to understand the direct importance of the soils 3-D matrix on the regulation of microorganisms involved in denitrification, nitrification and immobilisation. With the latest developments in technology this is now achievable at a micro- to nano-meter scale. Findings will be of direct relevance to the sustainable management of N in soil and from soil to water and atmosphere. In particular we address three key areas of thematic priority No 6: (i) greenhouse gases, (ii) water cycle and soil, and (iii) sustainable land management.",Spatial distribution of N processes and microbial communities in arable soils at micro- and nano- scales,FP6,31 January 2008,01 February 2005,217912.0 SPANG,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),manufacturing,"Carbon nanotubes grown by chemical vapour deposition or carbon arc method are fairly cheap but contain a considerable amount of defects and therefore the electrical and mechanical properties are far below their theoretical limits. In the laser ablation technique, nanotubes are produced under much better control of carrier gas flow and thermal gradients, but throughput is low and lasers are expensive. In channel spark ablation thermal gradients and gas flow are similar, but the process is much cheaper. The Arc-Jet method improves the flow conditions in the carbon arc (Kraetschmer) generator by injecting the carrier gas through a nozzle into the electric arc. The consortium will set up generators for channel spark ablation (Bologna), laser ablation (Stuttgart), and Arc-Jet production (Shanghai) and compare the products from these methods. To this end procedures for quality control and quality standardisation will be developed. These methods are based on optical and Raman spectroscopy, X- ray diffraction, and thermogravimetric analysis, as well as on mechanical investigations and electrical and thermal transport measurements (on pressed pellets, entangled films, and composites). The Austrian company AT&S Austria Systemtechnik AG is one of the largest producers of printed circuit boards. There is a general tendency to make these boards 'smarter' and to transfer passive electronic elements (resistors and capacitors) from the chips to the boards. AT&S envisages to use the nanotubes produced in this project for electronic elements integrated into their boards. AT&S has just started a subsidiary in China so that both the Chinese daughter and the European mother are likely to benefit from this project. The present project will produce high quality nanotubes at much larger quantities than presently available and at prices which are more than two orders of magnitude lower. We expect this to lead to a considerable breakthrough in #",Spark Ablation for Nanotube Growth,FP6,31 March 2007,01 January 2004,965000.0 SPANGL4Q,University of Bristol,photonics,"The goal of this project is the development of a suite of nanophotonic devices that interface with spins, for application in quantum information and quantum-enabled classical communi-cation technologies. Our technologies will be based on electron and nuclear spins in semi-conductor quantum dots (QDs) embedded in nanophotonic devices. We will combine knowledge of the physics of semiconductor spins, photonics and cavity quantum electro-dynamics, with quantum information and optical communication technology. In this FET-Open project, we anticipate that a wealth of novel devices and fundamental un-derstanding will result from the solution to one key problem. What is the best form for a hybrid spin-photon quantum memory, how does one transfer quanta of angular momentum from it to a single photon, and how will this angular momentum be encoded? This is an issue that is inadequately addressed so far, and we take highly novel approaches towards it. We address this question on several fronts. From the photonics side, polarization engineering in photonic nanostructures will be investigated, moving beyond linear polarization to exploit the full light angular momentum states. In terms of quantum memories, we will create the technology for long-lived (>1s) nuclear spin memories, long enough to achieve entanglement over large distances. These might one day be used over 1000's km and via satellites to po-tentially anywhere on the globe. Photonic crystal structures will be used for integrated quantum-optical circuit technology and plasmonic nanoantennas will enable a spin-dependent near-to-far field coupling, and ultra-fast control of the electron spin. One may use this spin-photon interface to entangle very large numbers of photons, with the memory allowing time for measurement operations of a quantum algorithm. The compatibility of these QD technologies means that the components may be combined, paving the way towards an entirely QD-based 'quantum internet'.",Spin-Photon Angular Momentum Transfer for Quantum-Enabled Technologies,FP7,28 February 2015,01 March 2012,2362711.0 SPANS,Consejo Superior De Investigaciones Científicas (CSIC),photonics,"This STREP project aims to study the underlying physical mechanisms of optical switching based on single-particle phase transitions triggered by light or electron-beam excitation and to demonstrate new types of nanophotonic switches based on this principle. The implementation of these ambitious research aims will require the development of new techniques to study active nanophotonic structures. We will for the first time combine nanophotonics with electron microscopy - employing sub-nanometre resolution diagnostic capabilities to achieve the deepest possible insight into the photonic switching process and to exercise electron-beam controlled switching. This technique will be particularly suited to the study of optical switches and will employ the evanescent field of the electron beam to truly probe the near-field regime of these devices in a non-intrusive fashion. More specifically, a new all-optical switch will be developed using light-induced phase transitions in nanoparticles where two or more phases can co-exist in metastable form. The reversibility of the phase transisions will be addressed, and the effect of the nanoenvironment will be investigated. Nanoparticles will be trapped by tips and analyzed both by measuring (1) scattering and absorption of light driven to the nanoparticles down optical fibers, (2) electron energy losses within transmission electron microscopes, and (3) light induced by those electrons. Our ultimate goals are (1) to demonstrate the ability of some specific nanoparticles to act as single-photon switches based upon optically-driven phase transitions and (2) to provide a general photonic nanostructures characterisation technique based upon electron microscopy that can have a significant impact in both the nanophotonics and the electron microscopy communitites.",Single Particle Nanophotonic Switching - Bridging Electron MIcroscopy and Photonics,FP6,31 October 2009,01 May 2006,755000.0 SPARKNANOTE,Queen Mary University of London,energy,"There is an increasing demand for alternative energy technologies to reduce our reliance on fossil fuels. One approach is to use thermoelectric (TE) materials to scaving waste heat energy and to convert it into useful electrical energy. Thermoelectric materials have the additional potential advantages that they could be: small, inexpensive, lightweight, quiet and pollution-free. These applications call for thermoelectric materials with high zT which requires higher Seebeck coefficient, higher electrical conductivity, and lower thermal conductivity. In this project, two strategies are used to reduce lattice thermal conductivity and then improve the zT: one is phonon-glass substitution within the unit cell by creating point defects such as interstitials and vacancies; another is the introduction of more interfaces on the nanometre scale. Using these approaches, we will identify promising optimised compositions, control the grain morphology and size, and sinter plate-like powders by Spark Plasma Sintering (SPS), to produce (Ag, Se, Ba, Yb, et al) doped Bi2Te3 and CoSb3-based bulk layer-textured nanomaterials. Through the optimization of the compostion, sintering process and microstructure it may be possible to significantly enhance zT. The main objective of this work is to develop thermoelectric nanomaterials and devices with zT values >2 to replace current commerical materials. Meanwhile, The research will also improve the fundamental understanding of these materials. At the microscale, stress and size effects on the thermal conductivity and zT properties will be studied and the mechanisms involved will be established.",Spark Plasma Sintering Nanostructured Thermoelectrics,FP7,14 October 2013,15 October 2011,210092.0 SPECCNT,Pierre and Marie Curie University * Université Pierre et Marie Curie,energy,"There has been considerable interest in derivatization of carbon nanotubes to modify their electronic, chemical, transport, etc. properties. Some examples are: i) functionalization of nanotubes to facilitate their manipulation, enhance their solubility, and make them more amenable to composite formation; lithium intercalated carbon nanotubes have attracted considerable interest for energy storage devices; the introduction of donor/acceptor levels through substitutional doping of the material to control the electronic properties; etc. However, from a theoretical prespective little is know about functionalized and intercalated nanotubes. This research project is dedicated to the theoretical/numerical characterization of intercalated and functionalized carbon nanotubes by the interpretation of nuclear magnetic resonance (NMR) and Raman spectroscopic data. These two techniques have an extremely high sensitivity to the local environment of a C bond. In particular, we will provide reference NRM and Raman theoretical spectra, in the search for clear signatures of the microscopic structure of the nanotubes. The signatures can be used to characterize macroscopic samples of tubes. To achieve these objectives, we will use state-of-the-art ab initio computational methods, due to their predictive power and reliability. This work will be done in close connection to experimental groups. In one hand, input from experiment will help assessing and validating the theoretical models. On the other hand the theory may be helpful to drive further experimental studies.This project will contribute to the building-up of basic knowledge in the strategic and highly impact area of nano-technology. In addition, the multidisciplinarity character of the project and its objectives will help to enhance European scientific excellence.",Theoretical Study of NMR and Raman Spectra of Functionalized and Intercalated Nanotubes,FP6,30 September 2005,01 December 2004,149670.31 SPECIAL,University of Minho * Universidade do Minho,health,"The SPECIAL project aims at delivering breakthrough technologies for the biotechnological production of cellular metabolites and extracellular biomaterials from marine sponges. These include a platform technology to produce secondary metabolites from a wide range of sponge species, a novel in vitro method for the production of biosilica and recombinant technology for the production of marine collagen. Research on cellular metabolites will be based upon our recent finding that non-growing sponges continuously release large amounts of cellular material. Production of biosilica will be realized through biosintering, a novel enzymatic process that was recently discovered in siliceous sponges. Research on sponge collagen will focus on finding the optimal conditions for expression of the related genes. Alongside this research, the project will identify and develop new products from sponges, thus fully realizing the promises of marine biotechnology. Specifically, the project will focus on potential anticancer drugs and novel biomedical/industrial applications of biosilica and collagen, hereby taking advantage of the unique physico-chemical properties of these extracellular sponge products. The consortium unites seven world-class research institutions covering a wide range of marine biotechnology-related disciplines and four knowledge-intensive SMEs that are active in the field of sponge culture, drug development and nanobiotechnology. The project is clearly reflecting the strategic objectives outlined in the position paper European Marine Strategy (2008); it will enhance marine biotechnology at a multi-disciplinary, European level and provide new opportunities for the European industry to exploit natural marine resources in a sustainable way. In particular the biotechnological potential of marine sponges, which has for a long time been considered as an eternal promise, will be realized through the SPECIAL project.",Sponge Enzymes and Cells for Innovative AppLications,FP7,30 November 2013,01 December 2010,2991682.0 SPEDOC,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),health,"Cancer causes an increased expression of Heat Shock Protein HSP70 in the peripheral blood, at the surface of, and in cancer cells as a result of different sources of stress, including anti-cancer treatments. It was recently demonstrated that tumorigenicity, metastatic potential and resistance to chemotherapy correlated with an increased of expressed HSP70 in cancer cells. On the contrary, HSP70 depletion using combinatorial small peptides called peptide aptamers sensitizes cancer cells to die and could help in cancer therapy. The core goal of this project is to combine the latest advances of nano-optics, optical manipulation and microfluidics with the ultimate understanding of HSP70 to develop a novel integrated and ultra sensitive sensing platform for early cancer detection. An early detection would benefit to traditional but also new cancer therapies based on peptide aptamers which could be delivered sooner and at lower doses. The planned sensing device, based on surface plasmon resonances supported by micro and nano-structures, will operate in a microfluidic circuit to minimize the volumes of analytes and increase reproducibility. Enhanced and confined plasmonic fields will be engineered at the nanoscale to implement two main sensing schemes: (i) ultra sensitive tracking of HSP70 proteins circulating in the peripheral blood based on resonance shift induced by specific protein/receptor binding, (ii) individual cell optical trapping (exploiting latest generation of plasmonics tweezers) combined with scattering imaging and Surface Enhanced Raman Scattering to monitor the concentration of HSP70 proteins at the membrane surface and achieve systematic cancer cell screening. These transduction mechanisms and plasmonic tweezers will be integrated into a compact platform to operate in a biological laboratory environment. Such a portable device should be seen as a precursor of a future device enabling point of care diagnostics in a medical environment and leading to individualized therapy.",Surface Plasmon early Detection and Treatment Follow -up of Circulating Heat Shock Proteins and Tumor Cells,FP7,30 June 2013,01 January 2010,1900000.0 SPIDERMAN,Leibniz Institute for Solid State and Materials Research Dresden * Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden eV,information and communications technology,"In 1990 Eaglesham and Cerullo [Phys. Rev. Lett. 64, 1943 (1990)] reported for the first time that three dimensional SiGe islands can be grown crystalline on Si, creating thus high expectations that these nanostructures could provide a valid route towards innovative, scalable and CMOS-compatible nanodevices. Two decades later the researcher has investigated for the first time their electronic properties by fabricating three terminal devices after integrating them on silicon on insulator substrates. The first results obtained so far indicate that SiGe self-assembled quantum dots have a rather unique combination of properties, i.e. low hyperfine interaction and strong spin-orbit coupling. The aim of this project is to study the potential of SiGe self assembled quantum dots for novel nanoscale devices including operation at room temperature. The objective of the present proposal is above all to: a) study spin-dependent transport in self assembled QD aiming to identify signature of spin precession induced by the spin orbit coupling b) study the characteristic time scales for spin dynamics in the SiGe QD system and move towards fully electrical coherent spin manipulation and c) realize a high performance p-type nanoscale transistor operating at room temperature. The experimental research proposed here may provide a new handle on the physics and control of electronic spins in silicon-based nanostructures with possible relevant implications for spintronics and spin-based quantum computation.",Electronic Transport and Spin dynamics through SiGe self-assembled quantum dots,FP7,09 June 2017,10 January 2011,100000.0 SPIDME,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The SpiDME (Spintronic Devices for Molecular Electronics) project aims both at the understanding of the interaction between the electron spin and its solid-state environment and at the fabrication of a new generation of molecular spin devices, which exploit the spin degree of freedom to store, carry and manipulate information. Spin and molecular electronics will be merged in the present project, with a view to expand the frontiers of current knowledge and deepen our fundamental understanding of spin transport phenomena at the molecular level. This would also pave the way to the fabrication of conceptually new devices at the interface between molecular electronics and spintronics, exploiting spin transport in molecules and molecular magnets. Our approach can be considered as a potential 'step forward' in the direction of future nanoelectronics. It has a clear advantage with respect to classical 'scaling down' solutions for spintronics: it builds electronic elements by using elementary functional units (molecules or nanometer scale clusters) that can be, to a large extent, engineered to match the requirements of the particular spin-application.",Spintronic Devices for Molecular Electronics,FP6,30 June 2010,01 November 2006,1299351.0 SPIN CURRENTS,University of Regensburg * Universität Regensburg,information and communications technology,"The proposed research topic belongs to the dynamically evolving field of semiconductor spintronics. In this field one tries to combine magnetic properties of semiconductor materials ('spin') with their versatile electronic properties ('electronics'). Adding the spin degree of freedom to the conventional semiconductor charge-based electronics or using the spin degree of freedom alone will add substantially more capability and performance to electronic products. The objective of the project is to explore novel schemes of generating and detecting spin-polarized currents in low-dimensional electron systems. This issue is still the fundamental problem in spintronics, as spin injection from metals into semiconductors using ohmic contacts turned out to be inefficient due to the conductivity mismatch problem. We want to focus on two methods of generating spin polarized currents. The first one employs the circular photogalvanic effect occuring in two-dimensional systems under illumination. We want to provide an experimental proof that resulting photocurrent is indeed spin-polarized, as predicted by theory. In the second of dicussed methods we plan to use a ferromagnetic semiconductor (Ga,Mn)As as a spin injector. This way we want to overcome a low degree of spin injection into semiconductors achieved so far due to conductivity mismatch problem. The degree of obtained spin polarization will be measured using Quantum Point Contacts formed within a two-dimensional electron gas. We believe that the project will contribute to the progress in the field and will advance the spintronics expertise within the EU, increasing its scientific competitivness. Simultaneously it will provide the researcher with the advanced training in spintronics-related research and prepare him to the independent research career.",Generating and probing spin-polarized currents in low-dimensional semiconductor systems.,FP6,30 April 2007,01 May 2005,160466.0 SPIN-OPTRONICS,"Blaise Pascal University * Université Blaise Pascal, Clermont-Ferrand II",photonics,"We propose to join the forces of ten leading European teams in order to achieve a critical mass in the new research field of Spin-Optronics, a vast novel research area at the crossroads of fundamental physics of quantum-mechanical spin, optoelectronics and nanotechnology, and establish the European leadership in this area on a world-wide scale. All three main directions of the Network research activities -growth and technology, spectroscopy and theory - will be concentrated on novel spin and light polarisation effects in nanostructures, utilising confinement of not only charges and spins, but also photons. In this field, the information is ultimately carried out by the spin of photons, can be encoded in the confined spin state and manipulated on the nano-scale and redelivered in a form of polarised photons. The four main project objectives are : 1°) Coherence of individual spin, storage of quantum information. 2°) Semiconductor entangled light sources. 3°) Interaction of free and localised spins in diluted magnetic semiconductors and hybrid structures. 4°) Spinoptronic devices based on cavity exciton polaritons. We are going to deliver a top level international level multidisciplinary training to 13 early stage researchers and 5 experienced researchers, offering them, in particular, a vast program of multinational exchanges and secondments. We will organise 4 project meetings, 3 schools and one final conference widely open to the whole scientific community. We expect this collaboration to achieve a breakthrough in establishing the fundament for the creation of new quantum devices and to overcome the existing severe fragmentation of research and training in this strategically important area, which is the main goal of our project.",Spin effects for quantum optoelectronics,FP7,30 September 2013,01 October 2009,3280068.0 SPINAM,University of Montpellier 2 Sciences et Techniques * Université Montpellier 2 Sciences et Techniques,energy,"This project leads to the development of novel MEAs comprising components elaborated by the electrospinning technique. Proton exchange membranes will be elaborated from electrospun ionomer fibres and characterised. In the first stages of the work, we will use commercial perfluorosulfonic acid polymers, but later we will extend the study to specific partially fluorinated ionomers developed within th project, as well as to sulfonated polyaromatic ionomers. Fuel cell electrodes will be prepared using conducting fibres prepared by electrospinning as supports. Initially we will focus on carbon nanofibres, and then on modified carbon support materials (heteroatom functionalisation, oriented carbons) and finally on metal oxides and carbides. The resultant nanofibres will serve as support for the deposition of metal catalyst particles (Pt, Pt/Co, Pt/Ru). Conventional impregnation routes and also a novel 'one pot' method will be used. Detailed (structural, morphological, electrical, electrochemical) characterisation of the electrodes will be carried out in collaboration between partners. The membranes and electrodes developed will be assembled into MEAs using CCM (catalyst coated membrane) and GDE (gas diffusion electrode) approaches and also an original 'membrane coated GDE' method based on electrospinning. Finally the obtained MEAs will be characterised in situ in an operating fuel cell fed with hydrogen or methanol and the results compared with those of conventional MEAs.",Electrospinning: a method to elaborate membrane-electrode assemblies for fuel cells,FP7,31 December 2017,01 January 2013,1352774.0 SPINAPPS,SpinRoc SAS,information and communications technology,"Nanoelectronics will pave the way for industrial innovation in Europe in the next decade, and novel nanoelectronics areas such as spintronics offers solutions to many current problems by means of smaller, lighter, faster and better performing materials, components and systems. Applied spintronics is expected to make some essential contributions to solving increasingly acute problems of miniaturization in the wireless marketplace. It promises to deliver wireless devices that combine all common radio standards while keep power consumption to a minimum. It makes possible life-saving vehicle radar systems at a fraction of the prize of today’s systems. A huge positive impact on the safety and security of the European citizen is expected. The core technology of our SpinApps proposal is the Spin Torque Oscillator (STO). By utilizing a novel technology similar to that used in the recently introduced magnetoresistive read access memory (MRAM), a sub-micron radio frequency oscillator can be realized, with a wide operating frequency range and without any of the limitations of the classical oscillator circuit. This IAPP project bring together highly driven Euroepan researchers and engineers from Sweden's largest technological university and a laureated French start-up company. This unique combination offers the possibility to bridge the gap between laboratory demonstrations and commercial applications. It connects two different regions, two different sectors and promotes knowledge transfer across both borders. The SpinApps IAPP is the kind of project that Europe needs to stay competitive through constant innovation. Where large companies often cannot introduce the necessary disruptive technologies, SMEs and start-up companies must collaborate with universities to fill in in their place.",Spin Torque Oscillators for Wireless and Radar Applications,FP7,02 May 2014,03 January 2008,519776.0 SPINKOND,Adam Mickiewicz University in Poznań * Uniwersytetu im. Adama Mickiewicza w Poznaniu,energy,"The unavoidable limitations of further miniaturization of electronic circuits stimulate the search for new information and storage technologies. Spintronics is one of the major new directions that emerged in recent years - it aims at using the additional degree of freedom, namely the spin, to store and process information. One of the most promising candidates for future spintronics devices are nanostructures such as molecules and quantum dots. However, in order to exploit such devices in spin nanolelectronics, it is crucial to fully understand their behaviour and properties. The main objective of this research project is to gain further insight into spin-resolved transport properties of complex quantum dot and molecular structures coupled to leads exhibiting either ferromagnetic or superconducting correlations. The emphasis will be put on the strong coupling regime, where electronic correlations lead to the Kondo effect. In particular, the considerations will include the analysis of the SU(4) Kondo effect in double quantum dots and carbon nanotube dots and thermoelectric effects in spin-resolved transport through Kondo quantum dots and molecules. The transport characteristics of hybrid quantum dots, in which one of the leads is ferromagnetic while the other one is superconducting, will be also considered. All these nanostructures have become particularly interesting in view of recent experiments. The calculation of transport properties will be performed by using the numerical renormalization group methods with state-of-the-art improvements -these are known as the most powerful and exact methods to address transport through quantum dot and molecular systems. The results obtained will provide new insight and understanding of current and future experiments on transport through various magnetic nanostructures in the Kondo regime. They will be also published in refereed scientific journals and presented at international conferences and workshops.",Spin effects in transport through magnetic nanostructures in the Kondo regime,FP7,31 January 2016,01 February 2012,100000.0 SPINMANYBODYSEMINANO,University of Regensburg * Universität Regensburg,photonics,"We propose systematic extensive investigations of many-body spin phenomena in semiconductor nanostructures, with a goal to find effective magnetic/spin mechanisms to tailor various electronic anisotropies, potentially useful in device structures. The two principal Bychkov-Rashba (BR) and Dresselhaus (D) spin-orbit interactions (SOI) will be explored. We plan to calculate the anisotropy of the Friedel oscillations and of the many-body renormalization of the electron mass. We propose to design a device scheme to control the effective mass through the relative strength of the BR and D couplings. We'll study the effect of exchange and correlations on the SOI induced anisotropy of plasmons. Another goal is to investigate the SOI effects on the charge and spin Coulomb drag (CCD and SCD). We'll focus on two effects, related to (i) the new drag channel, induced by the inter-chirality transitions, and (ii) the dominance of large-angle-scattering events in CCD and SCD. This requires accurate calculations with the use of the exact Lindhard polarization function. Recently we have shown that SCD is suppressed in wide quantum wells. Here we propose to study a crossover from Coulomb to phonon-mediated spin drag with an increase of the carrier density and the well width. Another goal, related to the phonon system, is the calculation of spectral and damping properties of new complexes, coupled plasmon-optical phonon modes, in the presence of BR+D SOI. Next we propose to study spin phenomena in hybrid ferromagnetic-semiconductor nanostructures. We will focus on the SOI induced modifications of the magnetic edge states (the snake and cycloid orbits of electron spin) and on the induction and manipulation of spin currents along magnetic interfaces. Finally, we'll study side jump SOI as a mechanism to induce Spin Hall Drag in bilayers, coupled via Coulomb interaction. We put forward a method to probe electron spins in spatially separated layers with many-body interaction, and vice versa.",Spin and Many-Body Interaction Phenomena in Semiconductor Nanostructures,FP7,31 March 2011,01 April 2009,222124.0 SPINMET,University of Iceland * Háskóli Íslands,photonics,"The rapid progress of nanotechnology made possible the realization of nano-devices in which the motion of the carriers obeys the laws of quantum mechanics. They offer a unique laboratory for study of fundamental quantum effects, such as entanglement, topological phase and new states of matter arising from many- body correlations. Besides, mesoscopic objects can serve as components of the electronic and optoelectronic devices of new generation. In this perspective the study spin related phenomena is of particular importance as use of the spin degree of freedom opens a way to practical realization of such nanodevices as single electron memory elements, spin transistors, quantum beam splitters and spin filters. Another important topic in the field of mesoscopic transport is connected with many- body correlations, which manifest itself via variety of intriguing physical phenomena. In many of them spin plays a major role. The analysis of an interplay between spin dynamics and mesoscopic many- body correlations is thus an actual task. In a current Multidisciplinary Marie Curie FP7-PEOPLE-IRSES project SPINMET we plan to analyse many body spin related phenomena in various types of mesoscopic structures focusing on following main topics: i) Spin- interference phenomena in non-single connected mesoscopic objects ii) '0.7 anomaly' and related phenomena in 1D ballistic transport iii) New states of quantum spinor 1D liquids. iv) Spin currents and spin accumulation in real mesoscopic structures. The final objective to understand the mechanisms governing mesoscopic spin dynamics and its interplay with many-body correlations and formulation of practical recommendations for their applications in High-Tech industry: silicon spin transistor without ferromagnetic contacts; resistance standard based on the quantum spin Hall effect etc.",Spin related phenomena in mesoscopic transport,FP7,31 May 2014,01 June 2010,396000.0 SPINMOL,University of Valencia * Universitat de València,information and communications technology,"In this project we intend to design new magnetic molecules and new classes of magnetic molecular materials which, conveniently nanostructured, can be of interest in molecular spintronics, quantum computing and, in general, in nanomagnetism. The project pretends to cover either the development of molecule-based materials with interesting spintronic properties (molecule-based spintronics), as well as the design and study of magnetic molecules of interest in unimolecular spintronics and quantum computing. The objectives will be the following: - Use of molecule-based magnets for the preparation of multilayered spintronic structures (molecular spin valves) - Design of molecule-based magnetic materials exhibiting multifunctional properties (ferromagnetic superconductors, magnetic multilayers and magnetic/conducting multilayers) - Nanopatterning of magnetic nanostructures on surfaces via a molecular approach. - Chemical control of quantum spin dynamics and decoherence in single-molecule magnets based on magnetic polyoxometalates with the aim of developing qu-bits based on these inorganic molecules. - Positioning and addressing magnetic polyoxometalates on surfaces. An unconventional strategy of this project is the use of purely inorganic building blocks, as well as of inorganic magnetic molecules to design these magnetic materials, instead of using metal-organic molecular systems. This purely inorganic molecular building-block approach will benefit from the robustness of this kind of molecules and materials. Another characteristic feature of this project is the combination of top-down and bottom-up approaches for the processing of the molecules / materials. Thus, the project will exploit the advantage of using lithographic techniques (high throughput, easy scalability, etc.) in combination with the chemical bottom-up design of the molecular system, for the nanopatterning of the materials and the positioning of the molecules on surfaces with nanoscale accuracy.",Magnetic Molecules and Hybrid Materials for Molecular Spintronics,FP7,02 April 2017,03 January 2010,1679700.0 SPINTORQOSC,University of Barcelona * Universitat de Barcelona,health,"The project aims at studying spin-wave excitations from nanocontacts and implementing biological inspired computations with wavefronts in nano-structures, likely in terms of spin waves in ferromagnetic films. This implies building a bridge between Mathematical Neuroscience and Applied Physics. It is also of great importance to create a new research line at the emph{Magnetics Laboratory Group} at UB with Prof. J. Tejada and Dr. J. M. Hernandez based on nanofabrication of magnetic devices sensors in order to study gyromagnetic phenomena and the patterning of spin dynamics at the quantum level. Nanoscale, current controlled spin-torque oscillators (STOs) are of great fundamental interest and also of interest for signal processing and communication, including on-chip communication via spin-wave propagation. However, the fundamental characteristics of the spin-waves emitted by STOs are unknown. STOs, consisting of a point contact to a thin film ferromagnet (FM), were first proposed theoretically in 1996. High DC current densities generate a high-frequency dynamic response (up to 100 GHz) in the FM layer and can result in the emission of spin-waves. Studies of STOs to date have relied primarily on electronic transport characteristics. Further studies have shown these oscillations may be phase-locked to an external rf source, via a process known as injection locking, providing a means of conducting time-resolved spatial imaging. The aim of the proposed work is to study the fundamental characteristics of spin-waves generated from STOs using full-field transmission x-ray microscopy (TXM), combined with x-ray magnetic circular dichronism (XMCD) to provide magnetic contrast. We will determine the physical requirements for implementation with STO's of a novel computational framework based on polychronous wavefront dynamics using temporal and spatial patterns of activity in pulse-propagating media.",Spin torque oscillators with applications in non digital computing science and communications.,FP7,31 May 2014,01 April 2011,234337.0 SPINTRANSFER,IMEP-LAHC Laboratory,information and communications technology,"Control and manipulation of spins is undoubtly one of the major challenges in nanoelectronics for the next decades. The goal of this ambitious project is to realize coherent transport of a single electron spin in a scalable condensed matter system. Presently, one can achieve extremely high control of an electron spin using semiconductor quantum dots, the elementary brick for spin based quantum computer. In order to manipulate and control spins individually on a large scale one has to be able to transport coherently a single electron spin from one place to another in quantum nanoprocessors. The coherent spin transport is the missing piece to the teleportation protocol and to the non-local interaction between distant qubits. Such an approach will open new possibilities to the field of spin-based quantum information processing and is an essential step towards coherent control of a large number of Q-Bits.",Coherent transport of a single electron spin in semiconducting nanostructures,FP7,09 June 2013,10 January 2008,45000.0 SPINTROS,Centro de Investigacion Cooperativa en Nanociencias (CIC nanoGUNE),health,"Spintronics is an area of electronics that aims to exploit the spin of the electron. Although it is one of the areas selected to play a role in the post-CMOS electronics, spintronics still has to prove its full potential in many fields. A particularly important is the long distance spin transport and manipulation. Organic semiconductors (OSC) can play an important role in the development of spintronics as they have very small spin-orbit and hyperfine interactions, which lead to very long spin coherence times and make them ideal for spin transport. However, the basic mechanisms of spin injection, transport and manipulation in OSC are still obscure, thus impeding further advances in the field. The objective of this project is to understand and control spin transport in organic semiconductors. To achieve this ambitious objective we will employ a multidisciplinary approach, merging materials science, electronics and physics. In the two initial workpackages, we will study the unique combination of ferromagnetic spin-polarized injectors and OSC spin transporters, especially their energetic and magnetic interactions at the interface. We will also create optimized organic field-effect transistors (OFET) with nanometre channel lengths, the only device that would allow us to understand spin transport in a controllable fashion. In the third workpackage we will create and investigate the Spin OFET. Thanks to this device we will quantify the spin coherence length of OSC and we shall be able to control spin transport either by external (magnetic or electric field) or internal (crystallographic) effects. Finally, we will produce and characterize spin single molecular FETs. With this radical downscaling we will explore effects inaccessible in other transport regimes. For example, we will look at the direct coupling between the spin and molecular vibrational modes, or to the effect of the spin on the Kondo effect.",Spin Transport in Organic Semiconductors,FP7,31 March 2016,01 April 2011,1283400.0 SPINVALLEY,Universiteit Twente * Twente University,information and communications technology,"Spin-valleytronics is a promising new paradigm in electronics. Besides the spins of electrons and holes, valleys in the electronic band structure of some materials may provide another robust identity for information processing. Transition-metal dichalcogenide (TMD) monolayers, exhibiting a layered graphene-like structure, have intrinsically strong spin-valley coupling, essential for harnessing this new physics. However, the quality of the monolayers available at present precludes their use in prototype devices. This proposal aims to alleviate this. As a first objective, methods for high-quality epitaxial TMD monolayer growth using Van der Waals epitaxy will be developed. We aim at (i) simultaneous control over crystallinity, lateral size and thickness, and (ii) all in-situ growth and characterization using state-of-the-art surface science techniques. Next, we will develop non-destructive surface capping, for ex-situ characterization/processing, and molecular charge transfer doping techniques. The latter uses organic donor/acceptor molecules to tune the charge carrier density in TMD monolayers. Last, coupled spin-valley phenomena will be studied in TMD monolayers, for the first time by all-electrical schemes. These tasks require different disciplines, well matched with the applicant’s unique, well-documented profile, combining experience in magnetism, (organic) semiconductors, hybrid interfaces, nanofabrication, and surface science- and magneto-transport techniques. The strong expertise of the outgoing host (National University of Singapore) ensures training in the specialist growth and doping techniques, which have been pioneered mainly in Asia. After transferring these skills to the European host (University of Twente), magnetotransport studies of nanoelectronic devices are enabled by the excellent infrastructure available there. This fellowship will provide the applicant with a new level of professional maturity, enhancing and diversifying his research career.",Epitaxial transition-metal dichalcogenide monolayers for spin-valleytronics,FP7,04 June 2019,05 January 2014,301557.3 SPIRIT,Helmholtz-Zentrum Dresden-Rossendorf (HZDR),health,"SPIRIT is an Integrating Activities project integrating 7 leading ion beam facilities and 4 research providers from 7 Member States and 1 Associated State. The 7 partners providing TransNational Access supply ions in an energy range from ~10 keV to 100 MeV for modification and analysis of solid surfaces, interfaces, thin films and nanostructured systems. The techniques cover materials, biomedical and environmental research and technology, and are complementary to the existing synchrotron and neutron radiation networks. The partners have highly complementary equipment and areas of specialization. SPIRIT will increase User access and the quality of research by sharing best practice, balancing supply and demand, harmonizing procedures and extending the services into new emerging fields and to new users especially from the NMS and industry. An independent International User Selection Panel will examine proposals under a common SPIRIT procedure. Networking activities include the development of common standards for quality assessment; training and consultancy for User researchers and foresight studies. Joint Research Activities will promote emerging fields such as targeted single ion implantation for irradiation of living cells; ion-beam based analysis with ultrahigh depth resolution; ion-based 3-D tomography, and chemical and molecular imaging. Joint efforts are necessary to improve the systems for detection of ion-induced secondary radiation and to develop means to reduce sample deterioration by the analyzing ion beam. Finally, a unified software package for ion-beam based analysis shall be developed and made available to the community. The management structure of SPIRIT will consist of a Management Board, 3 Activity Boards (Networking, Transnational Access and Joint Research) and a Project Steering Team. A European Users Panel will provide input on user needs, evaluate service improvements against the benchmark level and assess new capabilities resulting from the JRA.",Support of Public and Industrial Research using Ion Beam Technology,FP7,31 August 2013,01 March 2009,6990864.0 SPIVOR,NASU - А. Usikov Institute of Radio Physics and Electronics,photonics,"The project is intended to reveal a unifying nature and fundamental geometrical features of the spin and vortex dynamics of classical electromagnetic and quantum-mechanical matter waves. The Berry phase, Magnus effect, and spin-Hall effect are attracting ever-increasing interest of scientists because of their potential applications in nano-physics, spintronics, quantum computing, etc. Simultaneously, the modern optics (including nano-optics, photonics, and plasmonics) offers unique possibilities to test and apply fundamental quantum-mechanical ideas within classical systems. The striking similarities of the spin and vortex dynamics in electromagnetic and matter waves call for an in-depth theoretical analysis which will be given within the framework of the present project. We will carry out extensive theoretical investigations of the propagation and scattering of electromagnetic waves in inhomogeneous and anisotropic media. A special attention will be paid to dynamics related to spin (polarization) and orbital (optical vortices) angular momenta of light. The research will be concentrated on various manifestations of spin-orbit-type interactions between intrinsic and extrinsic degrees of freedom of electromagnetic waves and quantum particles. We aim to develop a unifying theoretical approach to be able to describe specific features of behaviour of spins and vortices evolving in external fields. The approach will include the fundamental geometro-dynamical effects: the Berry phase, spin-Hall effect, and Magnus effect. Using scope of the host laboratory, we are going to perform experimental test of fine manifestations of these effects in classical optics, with potential applications to fiber optics, metamaterials, and remote sensing of turbulent atmosphere. We anticipate that realization of the project will contribute to the ability to control complex wave fields of different nature and, thus, will have a profound interdisciplinary impact and applications.",Geometrical aspects of spin and vortex dynamics in electromagnetic and matter waves,FP7,30 January 2013,31 January 2012,15000.0 SPIVOR,National University of Ireland Galway,photonics,"The project is intended to reveal a unifying nature and fundamental geometrical features of the spin and vortex dynamics of classical electromagnetic and quantum-mechanical matter waves. The Berry phase, Magnus effect, and spin-Hall effect are attracting ever-increasing interest of scientists because of their potential applications in nano-physics, spintronics, quantum computing, etc. Simultaneously, the modern optics (including nano-optics, photonics, and plasmonics) offers unique possibilities to test and apply fundamental quantum-mechanical ideas within classical systems. The striking similarities of the spin and vortex dynamics in electromagnetic and matter waves call for an in-depth theoretical analysis which will be given within the framework of the present project. We will carry out extensive theoretical investigations of the propagation and scattering of electromagnetic waves in inhomogeneous and anisotropic media. A special attention will be paid to dynamics related to spin (polarization) and orbital (optical vortices) angular momenta of light. The research will be concentrated on various manifestations of spin-orbit-type interactions between intrinsic and extrinsic degrees of freedom of electromagnetic waves and quantum particles. We aim to develop a unifying theoretical approach to be able to describe specific features of behaviour of spins and vortices evolving in external fields. The approach will include the fundamental geometro-dynamical effects: the Berry phase, spin-Hall effect, and Magnus effect. Using scope of the host laboratory, we are going to perform experimental test of fine manifestations of these effects in classical optics, with potential applications to fiber optics, metamaterials, and remote sensing of turbulent atmosphere. We anticipate that realization of the project will contribute to the ability to control complex wave fields of different nature and, thus, will have a profound interdisciplinary impact and applications.",Geometrical aspects of spin and vortex dynamics in electromagnetic and matter waves,FP7,31 July 2011,01 August 2009,183468.0 SPLASH,University of St Andrews,information and communications technology,"SPLASH addresses the issues of optical switches, tunable delay lines and optical buffering that is essential for realising the vision of all-optical data processing. The consortium will realise these functions by exploring optical slow light structures based on coupled ring resonators and photonic crystal waveguides. The core demonstrators are, a) Broadband slow light. Photonic crystal waveguides that combine sizeable slowdown factors with broad bandwidth and efficient optical coupling. b) Tunable coupler. By exploiting slow light phenomena in photonic crystals, the coupler will be very compact (10's of µm), yet require only refractive index changes of order 10-3 for complete switching. Tuning will be thermo-optic, electro-optic and all-optical. c) Tunable delay line. Tunable ring resonators will be used to continuosly control the delay properties of a system of coupled resonators. d) Switchable optical storage. By tuning/detuning the elements of a coupled resonator delay line, optical information will be stored. Structures will be realised in silicon on insulator technology to achieve the maximum compactness and maximum number of bits stored/unit area.",Slow Photon Light Activated Switch,FP6,30 June 2010,30 December 2006,1300000.0 SPOTLITE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"We intend toppling one of the most prominent paradigms in science: the diffraction resolution limit of an imaging or writing system relying on focused light. To achieve this goal we will pursue a radically new concept. We argue that effecting a reversible saturable transition with a focal intensity distribution featuring one or more local zeros should allow imaging and writing at the molecular scale. Compared to reported efforts (from our own group), the imaging and the writing shall be performed at 1000 to 1,000,000 times lower power. Unlike the established electron beam and scanning probe approaches, our technique accesses the sample's depth. Thus it will allow the non-invasive 3D-visualization of live cells and the writing of nanostructures in 3D. Imaging live cells on a macromolecular scale (<10 nm) would revolutionize our understanding of cellular function and disease. Verification of our concept will profoundly impact the field imaging and may even challenge the current multibillion ?/$ efforts in nanolithography to translate optical technology into the problematical deep-UV and X-ray regime. Our endeavour does not fall into the thematic priorities of FP6. It is risky but footed on quantitative predictions. Requiring joint efforts of chemists, biologists, and physicists alike, a broadly based breaking of the diffraction barrier is a truly interdisciplinary task. Conversely, light-based nanoscopy would reflect back on these disciplines as well as on their commercial exploitation. Our success will enhance the capabilities of key industrial areas, as diverse as the biomedical industry and information technology. The project's ambition is to establish optical nanoscopy in the same way, as the scanning probe microscopes were established in the 1980's. Breaking the diffraction barrier of focusing optical systems is one of the most challenging yet realistic goals in science to date, with great potential reward.",Molecular resolution with focused visible light,FP6,31 January 2008,01 February 2005,1300000.0 SPP,University of Exeter,photonics,"The project aims to establish the basis for a new type of photonics; one based on metallic materials rather than dielectric and semiconducting materials that dominate present day photonics technology.Metallic photonic materials demonstrate unique properties due to the existence on metals of electromagnetic surface waves known as surface plasmons (SPs). SPs are set to become part of the photonics revolution in which the interaction between light and matter is controlled by producing patterned structures that are periodic on the scale of the wavelength of light. SPs open up a wealth of new possibilities for photonics because they allow the concentration and propagation of light below the usual resolution limit. The field is now at a critical stage; impressive pioneering results have been reported but doubts persist about the practical utility of using SPs. The damping of SPs by absorption in the metal is usually considered to be serious enough to prevent exploitation. This project will expand on recent work indicating that such problems can be overcome by nano-structuring the metals involved, thus opening the way for exciting new photonic elements and devices. The project partners will provide long term interdisciplinary research into the phenomena that underlie surface plasmon photonics.. Nanostructure will be used to control the coupling between SPs and light and to control the propagation of light. Proof-in-principle demonstration experiments relevant to optical and photonic devices that employ SPs will also be undertaken. A particular feature of the project is the strong collaboration between theoretical and experimental researchers. Through such collaboration this project will develop new knowledge and provide an ability to design metallic nano-structures for specific photonic purposes.By providing a critical assessment of the viability of SPs for photonics the project will enable the potential for a new technology to be assessed.",SURFACE PLASMON PHOTONICS,FP6,31 December 2006,01 January 2004,1649113.0 SQUTEC,University of Stuttgart * Universität Stuttgart,health,"The development of quantum devices by nanoscopic control of constituents is expected to be one of the largest and most intriguing challenges of modern solid state physics. Among the degrees of freedom which allow exploiting most quantum phenomena are spins. Their long coherence and relaxation times make them of interest to any kind of quantum spin'tronics' from spin memories to quantum computing and ultrasensitive sensors. In well chosen and engineered environments spin state control and readout can be easy and robust even under ambient conditions. It is the aim of the present proposal to develop complex single spin systems from diamond defects and other dopant/host systems to a degree known hitherto only in atomic physics in terms of controllability and isolation from their environment. These systems should be used to investigate fundamental physical properties, e.g. the quantumness of solid state spins as well as their utilization in sensory devices. To this end spin defects should be implanted into ultrapure diamond materials with a spatial precision below 10nm. Their relaxation properties should be optimized to the ultimate (spin phonon interaction) limit and individual spin quantum states should be read out in a quantum non demolition-type measurement with highest possible fidelities. This on the one hand will allow the set up of versatile quantum arrays to e.g. study quantum many body physics. On the other hand such structures will yield sensors for magnetic and electric fields with unprecedented sensitivity and scale spatial resolution. Such devices might have revolutionary impact on imaging applications in various fields from materials' investigation to bio sciences.",Solid State Quantum Technology and Metrology Using Spins,FP7,29 February 2016,01 March 2011,2308000.0 SQWIRE,University College Cork,information and communications technology,"The aim of the SQWIRE project is to develop a disruptive, industry-compatible CMOS technology based on novel silicon nanowire transistor structures. The co-ordinator has demonstrated both theoretically and experimentally that nanowire MOS transistors can be fabricated at wafer level using silicon-on-insulator (SOI) substrates. These novel devices have shown electrical properties that are comparable or even superior to those of regular transistors.",Silicon Quantum Wire Transistors,FP7,08 July 2015,09 January 2010,0.0 SRPNICVD,Sabanci University * Sabancı Üniversitesi,health,"One dimensional nanotubular structures have a wide range of applications due to their unique physical and chemical properties that are different from the bulk materials. Metal and semiconductor nanotubes are being used as sensors, optoelectronic devices or transistors. Furthermore, polymeric nanotubes have great potential as biomedical devices due to the biocompatible nature of the polymers used. However, they are not as widely studied due to the difficulty of fabricating the nanotubular structures using common thin film deposition techniques. In this research, we propose to use initiated Chemical Vapor Deposition (iCVD) to fabricate polymer nanotubes. iCVD technique has been shown to successfully deposit polymer thin films while keeping the chemical moieties of the monomers intact. Furthermore, the crosslinking density and the wall thickness of the nanotubes can easily be tuned using iCVD as opposed to other techniques, such as solution-based techniques where the polymer should be soluble. Our proposal aims to develop nanocarrier systems of polymer nanotubes for various potential applications. A wide range of stimuli responsive polymers (SRP) will be used to fabricate the nanotubes and the mechanical and response characteristics of these nanostructures as a function of crosslinking density will be explored. In the next stage, coaxial nanotubes with both layers made of SRPs will be fabricated and the effects of the interaction between the layers on the release mechanism will be studied. The results of these studies will help us better understand the dominant mechanisms during uptake and release and thus enable us to fabricate the nanocarriers according to the response desired. Furthermore, these nanotubes with improved performance will have significant impact as drug delivery systems or sensors.",Stimuli Responsive Polymer Nanotubes by Initiated Chemical Vapor Deposition,FP7,31 August 2014,01 September 2011,75000.0 SSHOES,Instituto Tecnológico del Calzado y Conexas (INESCOP),health,"This project addresses the development and demonstration of new sustainable production capabilities for diabetic feet and fashion high added value consumer-centred product concepts, such as footwear and insoles and the conception and definition of industrial paradigms and infrastructures which relate to the footwear industry, characterised by large numbers of traditional SMEs exposed to global competition. The aim is to capitalise on new competitive strategies based on demand product differentiation and personalisation to deliver high quality to individual consumers. Specific addressed RTD topics will include: -innovative 3D integrated digitalization and design tools and solutions dedicated to personalised biomechanical and biomedical as well as style and aesthetics aspects; -adaptive production processes and technologies guaranteeing functionality, quality, performance and health; -micro and nano devices providing the product with innovative sensing and actuating functionalities, such as comfort, ease of use, control and modification of product properties (thermal, pressure distribution); -innovative high-performing materials with self-adaptive capabilities to optimally fit consumers physique and ergonomics, whilst guaranteeing comfort and aesthetic quality; -materials and production processes to achieve full ecosustainability of the product; -development of specific methodology for functional assessment of products considering environment of use and individual consumers; -dynamic human behaviour modelling, in particular lower limb (feet).",SPECIAL SHOES MOVEMENT,FP7,30 June 2012,01 July 2009,3509000.0 SSM-ILOPSH,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),information and communications technology,"Exploring the different relaxation mechanisms leading to spin decoherence and thus the realization of long spin lifetimes in single electron nanodevices is one of the central issues in nowadays spintronics. Although such effects have been widely studied in 2DEG-based nano-constrictions, the possibility of the utilization of stronger correlation phenomena characteristic to valence band holes on the transport properties of confined 2DHG systems has remained still unexplored. Recently it has become possible to C-dope (100) AlGaAs heterostructures for high-mobility 2-dimensional hole gases (2DHG) showing clear signatures of the fractional quantum Hall effect. Such structures lend themselves for the fabrication of quantum wires, quantum point contacts and quantum dots, provided they can be grown close (less than 100 nm) to the sample surface and that stable charging configurations can be obtained. The host institute has pioneered the fabrication of nanostructures with local oxidation of semiconductor heterostructures by using the biased tip of an atomic force microscope (AFM). The host has already demonstrated that oxide lines lead to laterally insulating behavior separating the plane of the 2DHG into various electrically disconnected areas. The proposed project aims to develop novel schemes for determining spin-related material parameters (g-factor, spin-orbit coupling strength) in various AFM lithographically defined 2DHG nanostructures via transport measurements. This is essential in order to explore electron spin dynamics, decoherence and relaxation in quantum dot and double-dot semiconductor spin qubits, and to determine conditions for coherent transfer of spin in nano/micro-circuits as well as methods of detection of spin currents. These experiments help to understand and control the coherent spin states of individual charge carriers, which is fundamental for the field of quantum computation in a solid state environment.",Single spin manipulation in locally oxidized p-type semiconductor heterostructures,FP7,08 July 2012,09 January 2008,178163.71 STABILIGHT,University of Eastern Piedmont * Università degli Studi del Piemonte Orientale,photonics,"The aim of STABILIGHT is the design and demonstration of novel nano-photonic devices based on all inorganic nanostructured materials operating at low DC voltage with enhanced photoemission activity and thermal stability to be used both in passive and active (transistor) light emitting devices. Materials and technologies involved are addressed to large consumer-markets such as automotive, information displays and lighting. Specifically advanced mesoporous films and new photonic nanostructures will be demonstrated along with their application to automotive display and info panel devices. The light emitting device developed in STABILIGHT will be characterized by an all inorganic active layer and electrodes on the same plane. The light is emitted on both sides. This device is designed to overcome the current limitations of OLED technology for automotive applications (low life-time at 80�C, very high investments, high cost because of the materials needed and relatively low yield because of the production complexity). The active layer is characterized by a host conducting porous matrix with a network of well organized nanocavities in which are embedded luminescent semiconductor nanocrystals. The nanosized ordered cavities in the form of a mesoporous film will be grown on substrates which can be either thin glass or nanocomposite polymeric materials with tuned bulk and surface properties with the addition of inorganic fillers (e.g. layered silicates). The porosity of the film will be tuned so as to trade off high light efficiency against reduced complexity of the device. The development of novel inorganic nanostructured materials having superior quality, reliability, sustainability and cost-effectiveness will allow an optimal incorporation into new nano-photonic devices. The proposed products and technological solutions are alternative to displays based on both organic and inorganic LEDs which are mostly developed outside Europe.",Novel Inorganic Nanostructured Materials and Devices with Enhanced Photoemission Activity and Thermal Stability,FP6,31 December 2008,31 August 2005,2331869.0 STAG,Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM),health,"Different multifunctional materials by design and their architecture can be switched to a different state or configuration at different length scales by means of an external stimulus. In STAG, we explore groups of organic molecular, supramolecular and polymeric materials that can be blended with polymers to add specific sensing capability to a thin film. The target will be to devise new functional systems who are responsive to exposure to a temperature above a threshold value and/or exposure to UV light. Chemical design will be synergically used together with nanotechnology processing based on bottom-up approaches to achieve specific patterns whose variations in size, shape, motion and local response of an anisotropic property (optical, electrical, magnetic) will indicate the time of exposure of the system to the external perturbation agent. Different paradigms for reading the exposure time will explored based on phenomena such as nanostructuring, emergence of correlation length scales, and cooperativity. These new materials together with the technology that will be developed could form the basis for a novel class of tags and storage media where digital information at high density will be coupled to sensing functionality to record the history of ambient exposure of products. Socio-economical impact of these class of materials in the long term is enormous, offering completely new capability to packaging, especially for food, beverage, pharmaceutical, and for their use in health, monitoring, anticounterfaction, safety and security.","Switchable multifunctional materials for quantitative monitoring Temperature, Ambient, and liGth exposure",FP6,30 November 2009,01 December 2006,2000000.0 STCSCMBS,Technical University of Berlin * Technische Universität Berlin,manufacturing,"The aim of the project is to perform advanced theoretical and computer simulation studies of nonuniform fluids involving complex molecules. It comprises of three work packages: (i) fluids in contact with tethered layers formed on surfaces and in pores, (ii) substrate driven self-assembly of supramolecular structures formed by complex organic molecules, and (iii) substrate induced self-assembly of nanoparticles with chemical dichotomy.",Statistical Thermodynamics and Computer Simulations of Complex Molecules in Bulk and at Surfaces,FP7,03 July 2016,04 January 2011,0.0 STEELPROST,European Convention for Constructional Steelwork,construction,"Current methods to provide fire protection of light steel structures include the nowadays most efficient approach of intumescent paints, which are typically applied on-site on a mounted structure using brushes or spray guns. Such treatments are generally achieved through the preparation of the surface by grit/shot blasting, followed by the application of a primer, and followed by the application of several layers of intumescent coatings. This methodology has a number of drawbacks for a large community of end users, including: a)Drying times of intumescent coatings are very long, resulting in high cost associated to labour, site disruption, and space required for painting; b) As a consequence of those significant costs and burdens, the reality is that many end users, particularly SMEs, end up applying fewer layers than required, uneven or irregular layers, or none at all, breaching therefore current legislation, facing serious penalties and fees and endangering the security of their own installations. The STEELPROST project aims to provide a solution to current surface treatment limitations, by developing a second generation of fire-protective coatings that are: easier to paint on, covering a larger area faster, having improved adhesion and quick drying properties. This will be achieved through 3 core innovations: 1)Development of low cost fire-retardant agents using novel tin-based technology, based on nontoxic halogen-free additives ; 2)Combination of the above fire retardant agents with further nanoparticle additives to confer the paint outstanding adhesion to the metal, and increase abrasion and wear resistance properties; 3)Design and optimisation of a procedure for fast curing of the coating using existing heating source technologies such as infra-red (IR). The proposed technology is expected to reduce steelwork treatment cost in constructional projects on a 25% for on-site applications and 50% for off-site application.",INNOVATIVE FIRE PROTECTIVE COATINGS FOR STEEL STRUCTURES,FP7,10 July 2014,05 January 2010,1871649.0 STEEPER,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),information and communications technology,,Steep subthreshold slope switches,FP7,11 June 2015,06 January 2010,0.0 STELE,Royal Institute of Technology * Kungliga Tekniska Högskolan,manufacturing,"New magneto-transport phenomena have been discovered in magnetic multilayers and are now being optimized for industrial applications, extending the conventional electronics with new functionality. However, most of the current research on magnetic multilayer materials and its device applications rely on conventional equilibrium electron transport. The full potential of nano-structuring, which leads to a broad spectrum of novel non-equilibrium transport phenomena, is therefore not realized. In this research project we will focus on practically unexplored functional principles that can be implemented in nanostructures produced by state-of-the-art lithography and surface manipulation techniques. Our main idea is to use electrically controlled spin currents in highly non-equilibrium regimes with respect to energy and temperature; hence “spin-thermo-electronicsâ€. The large amount of heat generated in nanoscale devices is today one of the most fundamental obstacles for reducing the size of electronics. In this proposal we turn the problem around by instead using electrically controlled local heating of magnetic nano-circuits to achieve fundamentally new functionality, relevant to several key objectives of the information and communication technology. Particular emphasis will be put on investigating and technologically evaluating the interplay of spin, charge, and heat in magnetic structures of sub-10 nm dimensions. Such structures, although inaccessible by today’s lithographic means, are in our view crucial for further miniaturization of electronic devices.",Spin-Thermo-Electronics,FP7,06 June 2014,01 January 2009,1741000.0 STEM CELLS COCOONING,Linköping University * Linköpings Universitet,health,"Stem cell therapy is believed to be the most viable method for restoration of cardiac function after Myocardial Infarction (MI), the leading cause of death in Europe. Despite numerous attempts at injecting stem cells into post-MI heart to affect regeneration, the consensus is that anoikis (cell death) induced by the lack of contact between the cells and the tissue scaffold during injection, the harsh environment at the injection site, and powerful myocardial contractions cause massive cell loss rendering the therapy ineffective. The goal of this project is to enhance treatment efficacy by individual cocooning of bone marrow stem cells in bioengineered collagen-based microspheres. The cocoon provides the tissue support for cell survival, promotes integrin upregulation for better engraftment of the cells onto the heart tissue, and protect the cells from the harsh post-MI environment. The spheres will be grafted with recognition moieties for the infarct areas, e.g. NGR peptide to enhance targeting. They will also contain growth factor VEGF to promote re-vascularization of ischaemic areas, and gold-coated silicon nanoparticles for in vivo tracking. The cocooned cells will be tested in vitro for their safety and efficacy (e.g. spheres degradation rate, cytotoxicity), and in vivo in MI mice models for their effectiveness in restoring heart functions by echocardiography, and for their traceability by dual-energy CT. As a Canadian researcher, I already joined the Liedberg group at Linkoping University, Sweden, in March 2011 as an Assistant Professor on a temporary, short-term basis to establish this project. My expertise in biomaterials and cell encapsulation combined with peptide, nanoparticle, and imaging expertise of the host laboratory are an excellent match for the success of the project. If the funding is granted, it enables me to extend my stay in Sweden to meet the goals of this beneficial project that will enhance collaborative research between Europe and Canada.",Stem Cell Cocooning for Targeted Cardiac Cell Therapy,FP7,31 October 2014,01 November 2012,181418.0 STEMOX,Complutense University of Madrid * Universidad Complutense de Madrid,photonics,"Here, we propose to explore and characterize new emerging phenomena in low dimensional (LD) and artificially structured oxide based systems by means of advanced electron microscopy techniques. Complex oxides have a large range of applications, since their properties change drastically as their precise composition and structure changes. When obtained in LD configurations new functionalities arise which are of fundamental interest in electronics, spintronics, energy or nanophotonics. We will use atomic resolution imaging and spectroscopy in the aberration corrected electron microscope to map their electronic, optical and magnetic properties by means of electron chiral dichroism. We intend to combine spectroscopic magnetic imaging with plasmonic measurements in order to explore, for the first time ever, the sensitivity of electron spectroscopy to magneto-optical properties at high spatial resolution. Our scientific mission will be to a) synthetize and characterize high quality oxide based LD systems and develop new imaging techniques, in order to b) explore new phenomena in systems showing unexpected behaviors. Our approach relies on comprehensive studies with atomic resolution, in real space, and when possible, at work (under the relevant temperature or pressure conditions). We will combine experiments with theory in order to interpret results and design new avenues to follow. This proposal has also a dual strategic component: 1) to create a new group in Spain devoted to study materials physics in such a way, and 2) to establish a world-class collaboration connecting the group to established growers and theorists, assembling a multidisciplinary team. The potential payoffs we envision are large, and many new and unusual materials, devices and phenomena are anticipated.",Under the light of electrons,FP7,31 October 2015,01 November 2009,1700000.0 STEMTRACK,University of Liverpool,health,"Regenerative therapies involving stem cells are now beginning to realise their potential. Their use for bone marrow transplantation is already a reality and their potential for the treatment of other degenerative diseases is being studied in clinical trials throughout the world. One of the challenges in stem cell therapy is the possibility to monitor the fate of stem cells once they are transplanted to a patient. This is of relevance given the need of stem cells to localise at the target tissue only, as their migration to other parts of the body can lead to adverse consequences. In this project, we aim at developing the technology which is necessary for long-term stem cell tracking. This will be based on the use of magnetic resonance imaging (MRI) in combination with contrast agents based on superparamagnetic iron oxide nanoparticles (SPION). Although contrast agents based on SPION are commercially available, none offer the potential for long-term tracking of stem-cells. This limitation is based on the observations that after a few weeks, these contrast agents are not retained by stem cells anymore. Additionally, the SPION tend to be slowly degraded in the cells, limiting the time frame in which they can be used. As potential adverse effects caused by stem cells would likely arise in a time scale of months or years, the need for monitoring them for such periods is of importance. Here, we aim at developing new SPION with multifunctional surface properties that will address these limitations. SPION will be designed and synthesised in order to exhibit targeting moieties that allow their internalisation and long-term retention within stem cells. The developed SPION will be evaluated in vitro in order to assess their cytotoxicity, internalisation dynamics and retention. Nanoparticles which are shown to be suitable for long-term tracking via MRI in vitro will be finally studied in vivo by monitoring bone marrow stem cells implanted in mice displaying a renal injury.",Engineering multifunctional superparamagnetic nanoparticles for long-term stem cell tracking,FP7,28 February 2014,01 March 2011,45000.0 STEPUP,MBN Nanomaterialia SpA,health,"An innovative mechano-chemical approach (based on the high energy ball milling) will be used for the development of innovative nanopolymers to be used in Rapid Manufacturing (RM) based on Selective Laser Sintering (SLS),by: 1.Structural modification (up nanopolymers stage) using a currently widely used polymer like Polyammide PA (a 'nanoPA' will be produced); 2.Alloying (at nanoscale) with different polymers to tune mechanical properties; 3.Nanocharging of polymers (development of nanocomposites). Moving from this background, the project will make a real, LARGE, step up in polymers and composites properties by including nano features into the base materials and the final products. The final products will benefit from radically extended performances (i.e. operating temperatures, increased strength). In this way it will be possible, using existing prototyping machines, to realize freeform manufacturing technologies for the direct automated and customised production of parts and products from small to medium size batches for a wide range of possible applications (from vehicle applications to biomedical devices). The following are the project S/T objectives of SLS materials and parts produced using the modified PA -New nanostructured materials based on Poliammides (PA) -Agglomerated (scale of 20-50 micron) nanophased (scale of 10-20 nm) particles suited for RM via SLS -Properties improvements in materials and RM/SLS parts properties (referred to conventional PA) of more than 200%. -Parts having improved properties and wider application window for automotive sector, consumer goods and medical instrumentation. For these reasons STEPUP responds quite well to the call topics by: introducing new concepts for the micro/nano fabrication (usage of nanoplymers); enabling transition of RM to customised solutions integrating materials design and simulations.",STEP UP IN POLYMER BASED RM PROCESSES,FP7,31 December 2012,01 January 2009,3159200.0 STIFNANO,ICN2 - Institut Català de Nanociència i Nanotecnologia,information and communications technology,"Integration of magnetic functionalities into electronic circuits requires the use of low cost, scalable methods focusing on the manipulation of magnetic moments by electric fields, as opposed to external magnetic fields. Spin polarized carriers can exert a torque to control the magnetization orientation. These carriers can be injected from ferromagnets (FM). They can also originate from the spin-orbit interaction, by using the Rashba, Dresselhaus and spin Hall effects. Ultimately, one may take advantage of the spin-textured states at the surface of topological insulators (TIs), a recently discovered new state of matter. The later 'spin-orbit torques' (SOTs) were recently observed in heavy-metal/FM and semiconducting structures. However, the mechanisms in play are under fierce debate, which is hindering technological progress.",Spintronics with Topological Insulator/Ferromagnet Nanodevices,FP7,03 July 2018,04 January 2014,0.0 STIMESI,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"The goal of the STIMESI Stimulation Action is to stimulate European universities and research institutes to adopt MEMS and SiP technologies in different ways. First of all the ¿more experienced¿ universities active in MEMS design/technology will be stimulated to increase MEMS research activities and design and fabricate more MEMS circuits and SiP components. Secondly it is also the goal to stimulate other universities to actively start teaching/research MEMS/SiP activities. In order to stimulate those universities and research institutes, they must be helped, guided, trained and they must get access to user-friendly design kits. In order to make sure that the MEMS/SiP technologies can be accessed easily by universities, qualified, robust and user-friendly design kits and design flows are being developed in the project. The development of robust MEMS design kits must link and include process capability, material properties, statistical and material tolerances. All this information must be integrated into the available MEMS CAD tools. As soon as the first versions of the design kits become available (second half of first year), training courses will be organised by the foundries. It is very important that trainees when returning home from courses and starting to make home exercises get additional technical support. The foundries organising and lecturing the courses will therefore provide technical assistance to the trainees for a certain time. It is also important that the courses can be used at the university to develop new teaching material so that the MEMS technology can be added in the curricula. A stimulation activity can only be successful with a good dissemination plan. This will include following activities such as a specific WEB site, leaflets and flyers on the different MEMS technologies, promotion of the training courses through various channels, an annual Workshop, etc.",Stimulation action on MEMS and SiP design,FP6,31 December 2009,31 December 2005,2320000.0 STIRENA,Queen Mary University of London,health,"This project aims to develop new stimuli-responsive nanoparticles (SRN's) reacting to changes in temperature and pH, and to evaluate their applications for both topical and transdermal drug delivery. New multifunctional materials, thermoresponsive as well as nanogels and dual pH-Tm responsive materials, using a combination of poly(N-isopropylacrylamide), poly(2-oxazolines) and chitosan will be synthesized and characterized. The main objective of this project will be to develop stimuli responsive nanoparticles based on the new multifunctional materials and evaluate their use as drug delivery nano-systems for skin application. Different techniques such as coprecipitation, oil/water solvent evaporation and high dilution radical polymerization will be used to generate nanoparticle with different physicochemical characteristics. Their clinical potential will be evaluated using preclinical in vitro skin models. The stimuli responsive nanoparticles proposed in this project may be characterized as an innovative approach to the development of new multifunctional skin delivery systems allowing the drug to be released, only when the tissue itself give the appropriate message, in terms of temperature and/or pH response.",Dual stimuli-responsive nanoparticles as novel topical drug delivery systems.,FP7,31 May 2015,01 June 2013,221606.0 STMOLTRANSTS,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),information and communications technology,"The aim of this project is to investigate the electronic transport through a single molecule bonded to a metallic electrode by local probe spectroscopy at low temperatures (0.5-6K) in atomistically controlled environments. We want to complement morphology, electronic and vibrational structure of the molecules obtained by scanning tunneling microscopy/spectroscopy by transport properties extracted from point contact spectroscopy. The direct comparison of point contact spectra with tunneling spectra offers a unique opportunity to deepen our understanding of the role played by the electronic and vibrational excitations in molecular electronic transport, and to get insight into the determining influence of the molecule-metal contacts. Our research will focus on molecules which can be considered as good candidates for the realization of an electronic switch. To this end, functional molecules with structural and/or electronic/magnetic bistability will be attached to a metal surface via carboxylate bonding. We aim to characterize the metal-molecule contact and also to tune the electronic transport through manipulation of the local contact environment. Another important issue which will be addressed in our investigation is the influence of magnetic interactions in the transport through a molecular wire, more specifically, we will focus on spin polarized transport of electrons through single molecules and in the Kondo screening. With the realization of this project we expect to get insight into the microscopic understanding of the electronic transport through a single molecule bonded to a metal, which is crucial in order to be able to employ molecules as electronic components at the molecular scale. Moreover, the training objectives of the project will complement and extend the applicants previous research experience resulting in a significant boost of his scientific career.",Probing single molecule-metal contacts and electronic transport by STM-STS,FP6,17 October 2008,18 October 2006,149154.0 STOMAMOTOR,Stichting Katholieke Universiteit * Catholic University Foundation,health,"The main goal of this ERC proposal is to harness a completely new approach to constructing biocompatible nanomotors, using supramolecular assembly of amphiphilic block-copolymers for loading the engine and catalysis as the driving force for autonomous movement. Polymersomes assembled from amphiphilic block copolymers can be further re-engineered to perform a controlled shape transformation from a thermodynamically stable spherical morphology to a kinetically trapped stomatocyte structure with controlled opening. These stable structures can selectively entrap catalytically active nanoparticles within their nanocavity making their design ideal for nanoreactor applications. The decomposition of hydrogen peroxide by an entrapped catalyst has been shown to generate a rapid discharge of gases and consequently generate thrust and directional movement. The design of the loaded stomatocytes is a truly miniature monopropellant rocket engine in which the catalytically active nanoparticles are the motor, the hydrogen peroxide is the propellant and the controlled opening of the stomatocyte is the nozzle. Their unique shape allows for added capabilities, extra compartmentalization for loading efficiency, polymeric PEG surface for biocompatibility and entrapped particles for catalytic activity. The supramolecular approach to assembling the motor allows facile alteration of its constituent parts: motor, fuel and cargo to make it more suitable for biological applications (type of catalytic particles, surface modification for cellular uptake or suitable biofuels). The appropriate design of the motor with recognition sites on the surface can facilitate the recognition, isolation and transport of specific type of cells, or can navigate the payloads within the cell via chemotaxis. Besides their initial role to overcome random diffusion, these 'ship-in-a-bottle' loaded stomatocytes open interesting possibilities for designing new targeted drug delivery and nanoreactor systems.",Stomatocyte Nanomotors: Programmed Supramolecular Architectures for Autonomous Movement,FP7,31 August 2017,01 September 2012,1500000.0 STONECORE,IBZ Salzchemie GmbH & Co. KG,construction,"STONECORE is a project dealing with the development and application of nano materials for consolidation and conservation of natural and artificial stone. Six SMEs, four universities, one public research organisation and one public body from seven countries have jointed together in order to find a new approach for refurbishment. The idea is to develop and test nano materials compatible to the components originally used during construction together with non destructive stone assessment methods. Colloidal sols of calcium hydroxide, calcium / barium carbonate, calcium sulphate or related compounds will be in the centre of interest. These materials will be used also as new, biozide free agents for mildew removal. The project will lead from laboratory investigations and small scale applications on trial areas to the use of the developed materials on selected real objects. It is a project that aims on knowledge based refurbishment of buildings as well as monuments of cultural heritage and that combines natural sciences and the art of conservation. Thus, main subjects of STONECORE are: • The development of nano materials compatible to natural and artificial stone for refurbishment of buildings, monuments, fresco, plaster and mortar, • The development and test of suitable technologies for their application and • The development and test of non destructive assessment methods (such as georadar) in combination with traditional assessment methods (SEM, XRD, drilling resistance and other). The project will have duration of three years. The results will be presented to the public and interested companies in three workshops, in which interested parties are invited to test the developed materials and techniques on own objects. The project contributes to the EC objectives by the development of materials and technologies allowing a reduction of the material and energy consumption during refurbishment, creating new business opportunities for SMEs and protecting the cultural heritage.",Stone conservation for the refurbishment of buildings,FP7,08 July 2013,09 January 2008,2453300.0 STREAM,University of Bayreuth * Universität Bayreuth,health,"This proposal aims to establish a novel type of kinetic experiment by combining microfluidics with micro-x-ray technology to develop a fundamental understanding of nucleation and growth of organic and inorganic nanoparticles, thus aiming to help producing these particles more efficiently in times of constraint materials resources. The methodology maps particle growth kinetics form the time- to the length scale. The proposed combination with microbeam x-ray diffraction extends the temporal resolution, determined by the spot-size of the microbeam, into the microsecond regime. This enables to elucidate nanoparticle nucleation and growth from early nucleation states to late growth states during which the shape of the particles is decided, thus opening pathways to new particle morphologies and improving existing synthetic procedures. The method is applied to the investigation of amphiphile self-assembly kinetics, inorganic nanocrystal growth and ultrafast polymer nanoparticle formation, where any improvement in the understanding of the growth mechanism is expected to directly lead to a more rational design of the synthesis, extending the range of morphologies and applications. That way, it is expected that STREAM can clarify particle nucleation and growth to expand the possibilities of nanoparticle synthesis to provide new and better materials for energy, information and medical technology.",Structural evolution at the nano- and mesoscale,FP7,30 April 2017,01 May 2012,2407400.0 STRENGTHNANO,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"In the proposed project, I will engineer the electronic and mechanical properties of freely suspended 2D crystals such as graphene by strain engineering. Although strain engineering has been aready proposed as a powerful way of fine-tuning the electrical and mechanical properties of 2D crystals to create artificial 2D materials with novel functionalities, experimental studies of the role of strain in the electromechanical properties of 2D crystals are still very scarce.",Strain engineering of atomically-thin nanomembrane-based electromechanical devices,FP7,03 July 2017,04 January 2013,0.0 STROCOMP,Autonomous University of Madrid * Universidad Autónoma de Madrid,photonics,"The improvement of fabrication technology over the last decades enables the accurate creation of almost arbitrarily shaped nanoscale metal structures. In such systems, quasi-bound surface modes (plasmons) provide strong, sub-wavelength confinement of electromagnetic fields. This confinement leads to strongly increased coupling between light and matter, and increases the possible spatial resolution to far below the diffraction limit. These properties make plasmonics a quickly growing and multidisciplinary subject, with applications in physics, chemistry, biology and engineering. A particularly relevant topic is the coupling of quantum emitters (such as atoms, molecules, quantum dots, or color centers in diamond) to plasmons. By concentrating light with the use of plasmons, the mismatch between the absorption cross section of the emitter and the size of the light beam can be circumvented. It is then even possible to reach the strong coupling regime, where the elementary excitations become hybrid states with mixed light-matter character. The major aim of StroCOMP is to develop new insights into the strong coupling between plasmons and organic molecule excitations, forming so-called 'plexcitons'. Due to the complex molecular structure, organic molecule plexcitons are still not fully understood. In addition to the system itself, we will study two relevant applications: One is the manipulation of chemical structure and reactions through strong coupling, exploiting the modification of the chemical potential energy surface. The second application is plexciton condensation, driven by their Bose-Einstein statistics. This exploits the possible ultralight effective mass of plexcitons to enable condensation and quantum degeneracy even at room temperature, and in addition to being of fundamental interest could represent a pathway towards a very low-threshold coherent light source.",Strong Coupling of Organic Molecules and Plasmons,FP7,31 August 2017,01 March 2014,87500.0 STROFUNSCAFF,Queen Mary University of London,health,"This work proposes the development of novel material and fabrication platforms to generate strong, tunable, and highly biomimetic nanofibrous hydrogel scaffolds with an unparalleled level of control of both signaling and mechanical properties. The break-through element is the combination of elastin-like polymers (ELPs) and self-assembling peptide amphiphiles (PAs) to create nanofibrous hydrogels with an unprecedented combination of strength, tenability, and bioactivity. The proposed work aims to provide solutions to the current main limitations of self-assembling hydrogels. In addition, it describes novel fabrication methods to create unique biomimetic environments. The work is divided into 2 work packages. The first Work Package (WP1) aims to develop two material platforms designed to combine the benefits of ELPs and PAs. The second Work Package (WP2) aims to develop scaffold fabrication platforms with unprecedented complexity and precision exhibiting defined hierarchical features and spatio-temporal control of physical and chemical signals designed for cartilage or disc therapies. All the scaffolds will be validated in vitro using human cells. This is a critical component for the generation of human-based models and more efficient regenerative therapies.","Strong, functional, tunable, self-assembling hydrogel scaffolds for regenerative medicine",FP7,31 July 2018,01 August 2013,1492686.0 STROKECELLFUSION,Consejo Superior De Investigaciones Científicas (CSIC),health,"In the last years it has been shown that transplanted adult bone marrow derived stem cells (BMSCs) have the ability to fuse with cells of other types and restore several pathologies such as congenital liver failure and muscular dystrophy. On the nervous system, it was recently reported that bone marrow transplantation (BMT) made 24 hours after the stroke leads to a functional outcome. Cell fusion is one of the underlying mechanisms as it has been shown that it is indirectly implicated in the formation of vasculature after stroke. Thus, stroke is a pathology susceptible to be treated with this cell therapy mechanism. Despite the great potential of this mechanism of regeneration, the low frequency of fusion events, especially in the brain, has veiled and hindered the true regenerative potential of cell fusion. Therefore, the main objective of this project is to identify fusogenic factors that will increase cell fusion events to an effective level for cell therapy of neurological disorders. For this, firstly we will screen in vitro new putative fusogenic with the help of an in vitro cell fusion detection system and FACS analysis. Later, chitosan nanoparticles will be developed for the controlled release of the putative fusogenic factors. Finally, we will evaluate the in vivo efficacy of these factors trough a series of intravenous BMT co-administered with nanoparticles loaded with the selected factors in the mouse model of stroke. We will correlate an increment in the cell fusion events with the putative improvement in stroke symptoms. With this project we will improve our knowledge about adult stem cell plasticity and explore cell fusion process as a neuroregenerative process for the treatment of stroke.",Cell fusion as regenerative tool for stroke treatment,FP7,30 June 2012,01 July 2010,152917.0 STSON NANOSTRUCTURES,Autonomous University of Madrid * Universidad Autónoma de Madrid,information and communications technology,"The main goal of the research project that I propose for the next three years is the study of the electronic properties of nanostructures at the atomic scale. The investigation will be performed by means of low temperature scanning tunnelling microscopy/spectroscopy in ultrahigh-vacuum environments (UHV-LTSTM), a unique technique which allows the study of these electronic properties in a local way with atomic resolution. Thanks to this technique it will be possible to get the local electronic information of the nanostructures with ultimate energy resolution (<1meV) and also to modify the systems in a controlled way by direct manipulation using the STM tip. This will open the possibility to selectively modify the local environment of the nanostructures to study and also to create new nanostructures using as elemental building-blocks atoms and/or individual molecules. The investigation will be structured in three main research lines: On one side the electronic properties of nanostructures electronically decoupled from the substrate by means of ultrathin insulating films will be studied Two main kind of nanostructures will be examined; bidimensional metallic films and molecules both in single and self-assembled arrangements. In a second line these same nanostructures, now adsorbed on epitaxial graphene, will be investigated. Special emphasis will be put in the influence of the Dirac quasiparticles of graphene in the electronic properties of the nanostructures and also in understanding and/or controlling how the adsorption of these nanostructures locally or even globally modify the electronic properties of graphene itself. The third research line will be focused on the study of phase transitions in the metal semiconductor systems Pb/Si(111), Pb/Ge(111) and Sn/Ge(111) at 4K. One of the fundamental questions to understand the temperature evolution of these 2D systems is precisely to know which is the true ground state at the lowest temperature.",Investigation of the electronic properties of nanostructures at the atomic scale by means of low temperature scanning tunneling microscopy/spectroscopy in ultrahigh vacuum conditions,FP7,10 July 2014,11 January 2009,45000.0 STUFFOR,Keele University,health,"The use of Acellular Technology to stimulate the body's own repair processing is an emerging direction in regenerative medicine, which may tackle one of challenges in orthopedic treatment where how to treat bone loss or bone fracture due to osteoporosis is unsolved. The main objective of this project is to biofabricate new bioinspired scaffolds enabling off-shelf, scalable and stimulating multiple cellular actions including stem cell infiltration/adhesion; differentiation of osteoblast and endothethial cells for treatment of bone defects. The proposal will develop new multifaceted 3D composite scaffolds combined the advantages of electrospun nanofibers, porous foam and active chemicals conjugation enabling to provide biological, physical and mechanical properties for mesenchymal stem cells adhesion, migration, and differentiation and angiogenesis. The proposal will also develop an in vitro dynamic culture model mimicking bone development in vivo to evaluate the efficiency of scaffolds in order to reduce the use of animal models. The project proposes to bring an outstanding young researcher, Dr Lü, who was trained in the State Key Laboratory of Bioelectronics in Southeast University, the top 20 university in China, to undertake such multidisciplinary research project with host institution in Keele University, UK. Dr Lü has worked in biofabrcation field in past 5 years, and have established excellent track record in smart nanofiber fabrication and applications. The fellow's experience and knowledge will be effectively transferred to host group and other European research groups through the delivering the targets of the project and disseminating of her previous research outcomes by seminar, joint publication and visiting other laboratories. The fellowship will also aim to build collaboration with third country through Dr Lü's research links in China after the fellowship, which will enhance European knowledge-based economy in general and healthcare in specifically.",Smart acellular scaffolds for bone repair,FP7,08 December 2015,09 June 2014,173462.0 STUFFOR,Southeast University,health,"The use of Acellular Technology to stimulate the body's own repair processing is an emerging direction in regenerative medicine, which may tackle one of challenges in orthopedic treatment where how to treat bone loss or bone fracture due to osteoporosis is unsolved. The main objective of this project is to biofabricate new bioinspired scaffolds enabling off-shelf, scalable and stimulating multiple cellular actions including stem cell infiltration/adhesion; differentiation of osteoblast and endothethial cells for treatment of bone defects. The proposal will develop new multifaceted 3D composite scaffolds combined the advantages of electrospun nanofibers, porous foam and active chemicals conjugation enabling to provide biological, physical and mechanical properties for mesenchymal stem cells adhesion, migration, and differentiation and angiogenesis. The proposal will also develop an in vitro dynamic culture model mimicking bone development in vivo to evaluate the efficiency of scaffolds in order to reduce the use of animal models. The project proposes to bring an outstanding young researcher, Dr Lü, who was trained in the State Key Laboratory of Bioelectronics in Southeast University, the top 20 university in China, to undertake such multidisciplinary research project with host institution in Keele University, UK. Dr Lü has worked in biofabrcation field in past 5 years, and have established excellent track record in smart nanofiber fabrication and applications. The fellow's experience and knowledge will be effectively transferred to host group and other European research groups through the delivering the targets of the project and disseminating of her previous research outcomes by seminar, joint publication and visiting other laboratories. The fellowship will also aim to build collaboration with third country through Dr Lü's research links in China after the fellowship, which will enhance European knowledge-based economy in general and healthcare in specifically.",Smart acellular scaffolds for bone repair,FP7,,,7500.0 SUBLIMA,Philips Technologie GmbH,health,"The SUBLIMA project aims at truly simultaneous, fully integrated, solid-state PET/MR technology for concurrent functional and anatomical imaging with unsurpassed image quality. It will combine the extremely sensitive functional imaging possibilities provided by PET with the excellent soft-tissue contrast and complementary functional imaging capabilities of MR. For the first time, time-of-flight (ToF) and depth-of-interaction (DoI) correction will be introduced together into a PET/MR system. SUBLIMA will also be the first to exploit the unique advantages of truly simultaneous PET/MR acquisition by enabling fully 4D MR-derived motion correction. Furthermore, artefacts seen in PET-CT will be eliminated by developing MR-based, motion-compensated PET attenuation correction. The SUBLIMA platform will thus realize a breakthrough in image quality and enable novel applications in oncology, cardio-vascular medicine, and neuro-degenerative diseases. SUBLIMA will not only introduce new methods and technologies in each important component of the imaging chain, but it will also analyse the system performance as a function of all relevant design parameters, in order to push the image quality to the physical limits by optimally merging these innovations into 7T preclinical and 3T whole-body human demonstrator systems. This integrated approach also warrants adaptation of the project results for optimum performance in stand-alone PET and SPECT applications. The consortium, lead by Philips, consists of universities, research institutes, industrial partners, and SMEs, spread over 7 different countries including the USA. While each partner has shown exceptional quality in its own field, the consortium brings together the wide and complementary range of expertise necessary to push the performance of ToF-PET/MR to the physical limits.",SUB nanosecond Leverage In PET/MR ImAging,FP7,28 February 2015,01 September 2010,1.1746804E7 SUBTLE,Julius Maximilians University of Würzburg * Julius-Maximilians-Universität,information and communications technology,"With increasing miniaturization of semiconductor electronics an increasing fraction of the power to the circuit is converted into nondeterministic signals that add to the ambient noise. In commonly used device concepts noise degrades the performance. Interestingly, there are cases where noise, instead of degrading the device performances, can lead to enhanced signal to noise ratios, if principles of Stochastic Resonance (SR) are used. The partners of the present proposal plan in a combined effort of groups working on device theory, nanofabrication and device characterization to investigate the feasibility and potential of SR nanoelectronic semiconductor devices. Using e.g. special FET like devices with tailored internal feedback the nonlinear dynamic transport properties in this regime will be explored for sensing and switching of sub thermal signals with the help of stochastic resonance-like dynamics. Within the proposal several key devices like 'residence time detectors' and 'electrochemical capacitance feedback transistors' will be realized and investigated for the first time. Concepts of integrated nanoscale circuits with efficient readout schemes, enhanced signal resolution in a noisy environment and stochastic resonance enhanced detection will be tested. By utilizing nonlinear transport in nanosystems the proposal has the potential to open a new window for electronic applications covering stochastic resonance phenomena, sub thermal switching and on chip noise control applications.",SUB KT LOW ENERGY TRANSISTORS AND SENSORS,FP6,30 September 2009,30 September 2006,1650000.0 SUBTUNE,Technical University of Darmstadt * Technische Universität Darmstadt,environment,"Wavelength-tunable lasers are key components for future reconfigurable optical networks and for cost-effective and compact telecommunication infrastructures. Moreover, a broadband and continuously tunable laser with high purity emission spectrum is a versatile tool for many sensing applications, e.g. for greenhouse gases (laser absorption spectroscopy) or deformations of buildings (fiber Bragg grating sensors).",Widely Tunable VCSEL using Sub Wavelength Gratings,FP7,12 July 2013,04 January 2008,0.0 SUGERT,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,"This Specific Support Action refers to the current IST Strategic Objective 'Pushing the Limits of CMOS, Preparing for Post-CMOS'. In order to achieve this goal and a good competitive situation of Europe in this area, well-directed and highly cooperative research activities are mandatory. The objective of SUGERT is to promote the optimization of European research activities in the field of Technology Computer Aided Design (TCAD), which is extremely important e.g. to reduce costs and time spent during the development of new semiconductor processes and devices. To this end, SUGERT will start from the consolidated industrial specifications for process and device simulation defined by the preceding IST User Group UPPER+, which will within SUGERT be updated according to the development of the industrial requirements and of the scientific state-of-the-art. In order to support and promote the implementation of research actions required to fulfill these specifications, SUGERT will transmit these specifications to relevant research groups in industry, at institutes and at universities. It will interact with these research groups to promote the efficient use of resources available from European, national or regional sources to carry out the research needed to match the industrial requirements. Furthermore, consolidated information on these industrial requirements and on the related expertise available in Europe will, together with suggestions for research activities, be given to relevant public authorities to support them in establishing their research programmes. SUGERT will organize the European contributions to the 'International Technology Working Group' on 'Modeling and Simulation' within the 'International Technology Roadmap for Semiconductors', which has the objective of defining world-wide specifications in their technical area. Overall, SUGERT aims at the optimum use of expertise and resources available in Europe in the field of TCAD.",Strategic User Group for European Research on TCAD,FP6,31 January 2008,31 January 2005,399999.8 SUN,Ca' Foscari University of Venice * Università Ca' Foscari Venezia,environment,"SUN (Sustainable Nanotechnologies) is the first project addressing the entire lifecycle of nanotechnologies to ensure holistic nanosafety evaluation and incorporate the results into tools and guidelines for sustainable manufacturing, easily accessible by industries, regulators and other stakeholders. The project will incorporate scientific findings from over 30 European projects, national and international research programmes and transatlantic co-operations to develop (i) methods and tools to predict nanomaterials exposure and effects on humans and ecosystems, (ii) implementable processes to reduce hazard and exposure to nanomaterials in different lifecycle stages, (iii) innovative technological solutions for risk management in industrial settings, and (iv) guidance on best practices for securing both nano-manufacturing processes and nanomaterials ultimate fate, including development of approaches for safe disposal and recycling. In summary, SUN stands for an integrated approach for the long-term sustainability of nanotechnologies through the development of safe processes for production, use and end-of-life processing of nanomaterials and products, as well as methods reducing both adverse effects and exposure to acceptable levels.",SUSTAINABLE NANOTECHNOLOGIES,FP7,03 July 2019,10 January 2013,1.0249962E7 SUNARQ,Consejo Superior De Investigaciones Científicas (CSIC),health,"The main goal of this project is to develop novel environmental friendly photocatalysts. The work would follow three principal directions: 1.Synthesis of novel heterogeneous TiO2 catalysts 2.Identification of the reaction mechanism 3.Applications in environmental/human-health problems, such as priority organic pollutants and harmful microorganisms in gas and liquid phase. Many of the photocatalytic reactions reported so far are activated by UV light and do not exploit the 'green' potential of the method. Here, new TiO2 catalysts will be developed to achieve efficient photocatalytic activity in the visible light range based on: i) the exhaustive exploration of co-doping of TiO2 controlled nanoarquitectures (size/shape) with metallic (Fe, V, W) and nonmetallic (N) ions. ii) Synthesis of novel hybrid TiO2 based biomaterial with an inorganic component based in step i) or alternative sunlight-active photocatalysts. These materials pose extended antimicrobial activities and will allow production of thin films and/or membranes. Polymer-oxide materials act as true 'remote' photocatalytic systems, eliminating the need of direct contact between the photoactive oxide and the pollutants. They will be used for biological and/or chemical depollution, with easy recovery and reuse and long term stability, eliminating most of the drawbacks of powder TiO2 based photocatalysts. For the solid characterization and the identification of the reaction mechanism a joint and not explored Electron Paramagnetic Resonance, Diffuse Reflectance Infrared Spectroscopy, X-ray Absorption Spectroscopy and computational chemistry approach will be used. Emphasis will be put on the innovative use of time-resolved spectroscopies in a 'differential mode' at real 'operando' conditions and theoretical interpretation to unravel most important aspects of charge carrier handling, e.g. capture and fate while at surface and to firmly establish structure-activity relationships.",Novel sunlight-active nanoarquitectures for environmental and human health protection studied with a new multi-technique methodology at operando conditions,FP7,02 September 2012,03 September 2010,154417.0 SUNGREEN,University of Nova Gorica * Univerza v Novi Gorici,environment,"The SUNGREEN project seeks to reinforce the University of Nova Gorica, strengthening its innovative approach for research and development of new knowledge in environmental science and novel nano-structured materials. The reinforcement will be realized through establishment of strategic partnerships with top European R&D centres, recruitment of experienced researchers, acquisition of state-of-the-art research infrastructure, enhancement of UNG visibility and its collaboration with different stakeholders in the region. Through the implementation of the project, UNG will reach its full potential for research and technological innovation and will become one of the leading European research centres in the field environmental sciences and nano-materials. Excellent environmental science reputation of UNG is the result of integration of physics, chemistry, biology material science and computational science disciplines. Main objective of the project is strengthening of the research potential of UNG that needs new knowledge and research equipment. Project will enhance the capacity of UNG to successfully participate in research activities at EU level. The objective will be achieved through networking with other European world class research players, upgrading of relevant RTD infrastructure, recruitment of experienced researchers as well as through dynamic contribution to the regional and European sustainable socio-economic development through networking and dissemination activities.",Strengthening University of Nova Gorica Research Potential in Environmental Sciences and Novel Nanomaterials,FP7,01 July 2018,10 January 2011,0.0 SUNLIGHT,IMEP-LAHC Laboratory,energy,"In the search for cost-effective solar cells, colloidal inorganic semiconducting nanocrystals (NCs) have received much interest due to their readily-tunable absorption across the visible/near-IR, their high absorption coefficients and photostability. Yet many state-of-the-art NCs for photovoltaics are either based on toxic compositions or scarce elements on earth. It thus becomes essential to develop new systems from environmentally benign and earth-abundant elements with strong absorption properties. This project identified a few potential candidates, namely FeS2, Cu2S, CuO and Cu2ZnSnS4, due to their low raw material cost, their suitable band gaps, their high absorption coefficients and the availability of NC synthetic protocols. Relatively little work has been done on applying these NCs in solution-processed solar cells compared to those from II-VI/IV-VI groups, the Cu(InGa)(SeS)2 and Si systems. Specifically, this project involves the following aspects: 1. Optimization of synthetic methods for the above-mentioned NC systems. 2. Functionalization of NC surfaces with difference ligands via ligand exchange. 3. Realization of field-effect transistors based on NC thin films and investigation of the effects of NC size/morphology and ligands on charge transport. 4. Realization and optimization of solar cells based on NCs or NC/organic hybrids by correlating the effects of different synthetic and ligand conditions, improvement in light harvesting by the tandem cell approach. It can be anticipated that, by developing solar cells based on these new NCs, this project will gain fundamental understandings on how different NC and surface properties can impact the charge dissociation, transport, and recombination processes. The Marie-Curie grant would also consolidate the current efforts of this applicant, establish her further in her research and provide the ideal platform for her to become internationally leading in the field of applying colloidal NCs in optoelectronics.",Solution-processed nanocrystal photovoltaics from environmentally benign and earth-abundant elements,FP7,01 May 2017,01 January 2013,100000.0 SUPER,University of Strasbourg * Université Louis Pasteur de Strasbourg,energy,"SUPER will offer a multidisciplinary training to young researchers in the art of nanoscience and nanotechnology, in particular on the building-up of key units for the future organic nanoelectronics. Research will include synthesis, analysis, self-assembly of supramolecular (SM) architectures at surfaces, their characterization across a wide range of length and time scales and their use in the fabrication of wires, switches and motors operating at surfaces. Scanning Probe Microscopies (SPMs) will grant study of the nanoscale physico-chemical properties of self-assembled complex arrangements and the manipulation of single molecules embedded in a SM ensemble. Observing how the induced mechano-chemical transition is reflected on the neighbouring molecules, one can tune the properties of the SM architecture at surfaces, paving the way towards prototypes of nanowires. Nanofabrication of metallic nanoelectrodes and SM synthesis provide tools for the implementation of nanowires. Systematic studies on the optimisation of the conductivity of SM anisotropic objects will be done varying the wire (1) chemical composition; (2) conformation; (3) length; (4) doping. This will offer protocols for the fabrication of SM nanowires.SM switches operating at surfaces will be developed, where the motion will be triggered by different stimuli, i.e. light, variation of pH, an applied redox potential. Rod-like molecules capable of switching between coiled to rigid conformations will permit to bridge and unbridge the gap between two nanoelectrodes, controlling the on-off switching. Prototypes of molecular motors based on rotaxanes, where the switching is accompanied by an action, i.e. a delivery of a small moiety, will be fabricated. This research on the fabrication of key units for future nanoelectronics, will be vital for implementing organic based integrated circuits and for the optimisation of macroscopic devices, such as Light Emitting Diodes, Solar Cells and Field Effect Transistors.",Supramolecular devices at surfaces,FP6,30 June 2009,01 October 2004,670204.79 SUPERANTIBODIES,Imperial College London,health,"The project 'Superantibodies' encompasses an interdisciplinary approach to accomplish the first instance of a biohybrid, yet fully synthetic three dimensional recognition element by converging the benefits of natural biorecognition with those of a synthetic approach. The bio-inspired concept is modelled on the antibody binding site whose binding capacity is the result of a defined three-dimensional structure in which loops of polypeptides cooperatively interact with the antigen through specific biomolecular interactions. The project implements a combination of modern biomolecular and bioanalytical techniques to identify peptides within these structures that are pivotal for the interaction with the antigen, and to use organic chemistry to synthetically mimic these peptides whilst maintaining their biological function. Affinity driven self-assembly between these peptides and their specific antigen is used to produce templates for a subsequent molecular imprinting process, resulting in a site-specific integration of peptides into the structural backbone of a molecularly imprinted polymer. It is hypothesised that it will be possible to rationally engineer recognition elements with tailored affinities by changing the number and the type of the embedded peptides to rationally create structures whose affinity can outperform that of naturally derived antibodies. This proposal is built on the expertises and scientific strengths of Dr Heiko Andresen while taking him in new directions. The multidisciplinary group of Dr Molly Stevens provides a fertile environment for the scientific and professional development of the applicant, and Imperial's infrastructures and dedication to high-quality professional and personal career development strongly support Dr Andresen in reaching a position of professional maturity. The project proposal is in line with aims and policy objectives of the FP7, with particular high relevance for the theme-crossing FP7 initiative 'NanoMedicine'.",Synthetic Superantibodies -Bioinspired Engineering of Artificial Receptor Structures,FP7,30 April 2011,01 May 2009,171300.0 SUPERBLEND,Fundació Privada Ascamm * Ascamm Technology Centre,transport,"Since thermoplastic matrices can be replacing thermoset matrices in aircraft structural applications, the next step is to get eco-friendly thermoplastic materials able to be manufactured with less energy than PEEK.",Development of Thermoplastic Polymer blend with Low Melting Point and with Similar Properties than PEEK,FP7,09 June 2014,04 January 2011,0.0 SUPERIOR,University of Strasbourg * Universitè de Strasbourg,energy,"SUPERIOR aims at providing top-quality cross-disciplinary and supra-sectoral training to a pool of promising young researchers, in an area at the interface between Supramolecular Chemistry, Materials- and Nano-Science, Physics and Electrical Engineering. SUPERIOR appointees will be formally trained in lecture courses, dedicated schools and workshops, and through an ambitious and carefully planned research activity that benefits both from the expertise of world-leading senior investigators and of younger and energetic PIs with remarkable track records in both training and research. SUPERIOR is designed to generate new scientific and technological knowledge by combining supramolecularly-engineered nanostructured materials (SENMs), mostly based on organic semiconductors, with tailor-made interfaces to solid substrates and electrodes, for fabricating prototypes of optoelectronic devices. We are particularly interested in developing multiscale SENMs for transistors (FETs), in-plane diodes single-photon emitters, and especially solar cells (PVDs) and organic light-emitting diodes, OLEDs. The specific training and research objectives are: 1. Supramolecular synthetic chemistry of electrically/optically 1D and 2D (macro)molecules 2. Hierarchical self-organisation of multifunctional SENMs at surfaces. Multiscale SPMs studies of physico-chemical properties 3. Time-resolved photophysical studies of single-molecules and SENMs 4. Time-resolved spectroscopy of materials and devices 5. Modelling the geometric and electronic structures and the optical properties of SENMs 6. Advanced devices processing/(nano)fabrication 7. Formation of controlled interfaces of SENMs with substrate and electrodes 8. Devices I: FETs: Measurement of charge mobility in stacks, also upon photodoping. 9. Devices II: PVDs -addressing the charge collection problem. 10. Devices III: Emissive devices - Single photon emitters and OLEDs 11. Dissemination and strategic development 12. Management",SUPramolEculaR functional nanoscale archItectures for Organic electronics: a host-driven network,FP7,30 September 2013,01 October 2009,3793675.0 SUPERLION,Uppsala University * Uppsala Universitet,health,"On-board microbattery power is fast becoming essential in many of today's emerging technologies. Down-scaling in the micro-electronic industry has far outpaced advances in small-scale electrical power supplies. The absence of on-board power is a hinder to advances in many critical areas: micro-electronic devices and biomedical micro-machines. However, nano-materials and -structures provide new resources to attack the problem. MEMS devices will change our lives completely - given micropower sources. These include microsensor arrays, micro-vehicles, identification cards, memory backup, and biomedical micro-machines (pacemakers, defibrillators, neural stimulators, drug delivery systems). Insufficient power from 2D-MB configurations inspires this search for a 3D-MB using cheap and light micro-/nano-fabrication materials. We also probe whether related techniques can improve the performance of conventional Li-ion batteries. Can multicomponent assembly be replaced by a single interpenetrating nano-architectured anode/cathode element separated by an electrolyte? This would greatly cheapen conventional rechargeable Li-ion batteries for typically EV/HEV applications. Our major objectives are: • Synthesis and fabrication of novel nano-architectured battery materials and MB components. • Implementation in fully integrated thin-film 3D-MBs with current and power densities per unit footprint area of 70-100 μAh and 150-200 μW for 50-100 reversible cycles. • Implementation of at least some of these 3D-MB concepts in conventional normal-scale Li-ion battery fabrication. • 'Proof-of-concept' by showing that some 3D-MB device from the project can power both a MEMS and a medical device. The project thus establishes 3D nano-architectures, micro-/nano-fabrication approaches, and the enabling Science for a whole new generation of microbatteries.",Superior Energy and Power Density Li-Ion Microbatteries,FP7,31 August 2011,01 September 2008,2800000.0 SUPERQIP,Swiss Federal Institute of Technology * Eidgenössische Technische Hochschule Zürich (ETHZ),information and communications technology,"Recently it has been demonstrated that a single two-level system (the cooper pair box) can be coupled to a single (microwave) photon in a new on-chip superconducting architecture, circuit quantum electrodynamics (QED). This realizaton of cavity QED in solid state has great promise in quantum optics and quantum information processing. Investigation of this system will open up exciting possibilities of interconversion of quantum information between stationary and flying qubits, interfacing with other important quantum technologies (such as ion traps), and coupling between multiple spatially separated qubits. In this fellowship the system will be specifically explored for application to quantum computing, targeting the demonstration of qubit-photon and qubit-qubit entanglement, and multi-qubit quantum algorithms. The pursuit of these goals will be enabled by first experimentally optimizing qubit coherences and maximizing the qubit read-out fidelity. The project is hosted by a pioneer of the research field, and is set in the environment of world class facilities and high expertise in cavity QED at ETH Zurich. The fellow has valuable relevant experience in nanoscale device fabrication and microwave techniques, and will gain new skills in superconducting circuit fabrication, experiments at millikelvin temperatures, ultra-low noise and high speed microwave measurements, and expertise in the physics of quantum information processing and cavity QED. A high level of interaction with other research groups in Zurich, Switzerland and Europe is planned. The fellowship will hence be of considerable benefit to the fellow and apos; s career, and for the structuring of EU research in the emerging technology of quantum information processing.",Superconducting Quantum Information Processing with Circuit QED,FP6,31 January 2009,01 February 2007,173831.0 SUPERRAD,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),photonics,"Superradiance (SR) refers to spontaneous quantum phase transition, in which a self-organized build up of coherent radiation within an ensemble of quasi-degenerate emitters occurs. It was first noted by Dicke back in 1954 that, with increasing their density, the collection of N radiators starts to emit much faster and stronger comparing to spontaneous emission of individuals. More precisely, when packing up N identical emitters into the space comparable with a cube of the radiation wavelength, instead of observing isotropic and exponentially decaying emission, one produces a fierce, directional radiation burst, having a lagged peak intensity scaling like N2 and N-times reduced duration with respect to the spontaneous emission. Apart from the fundamental aspect, the research for SR is motivated by the prospects in producing ultra-short, intense, coherent light pulses - in alternative to lasers. The prerequisite for creating a SR emission is a spectral uniformity of participating transitions. For that reason SR was first successfully observed in atomic and molecular ensembles. As concerns semiconductor nanostructures, nowadays widely used in optoelectronics, the evidence for SR has never been provided, as the SR effect is obscured by the spectral inhomogeneous broadening in a semiconductor matrix. The goal of this project is to achieve the first proof for SR within an ensemble of individual emitters embedded in a nanostructured semiconductor. To this aim, we will focus our efforts on donor-bound-excitons (D0X), which are excitons (Coulomb correlated electron-hole pairs) localized on donor impurities in a semiconductor, for instance Si replacing Ga atoms in a GaAs lattice. D0Xs are characterized by small, sub-meV, inhomogeneous broadening, large oscillator strength and a few hundreds ps lifetime - all acting in favor for inducing SR. Our approach will employ methods of both linear (PL, streak camera) and nonlinear (up-conversion) time-resolved optical spectroscopy.",Demonstration of superradiance in a semiconductor nanostructure,FP7,28 February 2014,01 March 2011,45000.0 SUPERSONIC,AGH University of Science and Technology * Akademia Górniczo-Hutnicza im. Stanislawa Staszica w Krakowie,health,"The basic scientific and technological concept of the project is to use agglomerated nanophased powders to be transferred onto a substrate in the form a coating with very little or none change of crystal structure. This will allow to obtain nano-structured coatings with a crystal size very close to the powder one. The concept will be extended to an important breakthrough concept that is the 'Supersonic deposition of nanostructured surfaces' using multifunctional 'reactive' aggregated nanopowders for coating deposition: the residual chemical energy stored inside the material (uncompleted chemical reactions) can be developed during the deposition to assist deformation effects and contributing to bond together particles onto the substrate via creep/liquid phase sintering mechanisms. Many different systems will be explored pertaining to the aeronautical, mechanical and biomedical fields. The main S/T objectives of the project are: • Materials design of based on performance requirements; • Development of agglomerated (typically 20-50 microns size) nanophased powder classes (crystal sizes 10-20 nm) suitable for deposition using cold spraying containing either solid lubricants and/or residual chemical enthalpy in proper metal matrix; • Cold spraying process development for the 'reactive' deposition (wide range of adds in temperature), and self lubricating nanostructured coatings (synthesis of 'new' nanocomposite materials); • Development of three classes of nanostructured coatings for very relevant tribological applications (with self lubricating properties, abrasion and fretting resistance, biocompatibility) which suffer from a complete lack of solutions in the fields of bearings, machines parts and medical devices; The above objectives relates perfectly to the call content since it is intended to develop: novel nanostructured coatings; improved wear behaviour; chemical inertness; new generation of solid lubricants and tribological materials",SUPERSONIC DEPOSITION OF NANOSTRUCTURED SURFACES,FP7,30 November 2013,01 December 2009,4600000.0 SUPERTHEME,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,information and communications technology,,Circuit Stability Under Process Variability and,FP7,09 June 2017,10 January 2012,0.0 SUPERTRI,University of South Paris * Université Paris-Sud,information and communications technology,"In Superconductor/Ferromagnet (S/F) bilayer and F/S/F/S/F multilayer structures with ferromagnets with non collinear magnetizations of the F layers, Fominov and Volkov [1, 2] have predicted that a triplet component (i.e. Cooper pairs with electron spins pointing in the same direction) generated artificially. This effect occurs at angles where the magnetization of the F layers is no parallel to each other. In addition to the realization of the triplet state in these types of S/F multilayers, there is also the prediction of a transition from 0 to ¿ phase shift between neighbouring S layers. The possibility of switching between 0 and ¿ junctions opens a whole new range of applications in superconducting devices based on ¿triplet¿ ¿ -junctions. The aim of the proposed research is to investigate these types of structures for different angles of magnetization of the F layers and verify the predicted induced triplet state superconductivity. Triplet ¿ ¿junction research is a very promising field with new applications in the field of superconducting devices and quantum computing. The project here presented gives the possibility to realise these junctions with triplet pairing. A device which can switch from 0 to ¿ junctions and from singlet to triplet state superconductivity by applying external field would exhibit a functionality that is not possible using current S/F (singlet based) ¿ -junctions. Finally we have designed an experiment to investigate non locality of cooper pairs. The main idea is to share the two electrons of a Cooper pair in two different magnetic domains and measure the Josephson current for the parallel and antiparallel configurations. We expect the Josephson critical current to be zero in the parallel configuration, and finite in the antiparallel one. [1] Ya. V. Fominov, A.A. Golubov, and M. Yu. Kupriyanov. JETP Lett. 77, No 9, 510, (2003) [2] A. F. Volkov, F.S. Bergeret, and K. B. Efetov, Phys. Rev. Lett. 90, 117006 (2",Non-locality and triplet superconductivity in S/F hybrid nanostructures,FP6,31 August 2007,01 September 2005,0.0 SUPOCOSYS,Technische Universiteit Eindhoven * Eindhoven University of Technology,manufacturing,"This ERC Grant proposal aims to explore the many challenges offered by non-covalent synthesis of functional supramolecular systems. This proposal will use the many possibilities of supramolecular polymers and how we envisage the construction of supramolecular compartmentalized systems based on specific secondary interactions. By studying the mechanisms of the formation of supramolecular polymers, new entrees are foreseen to limit the degree of supramolecular polymers by anti-cooperative mechanisms and to control both the depolymerization and polymerization aiming at supramolecular polymerization processes out of equilibrium. These insights will be used to design, synthesize and self-assembly materials that dynamically adapt their properties to cells that are brought in contact with these biomaterials. With these materials, parts of a bioartificial kidney will be made. With all the knowledge obtained through the years, we have recently introduced a concept to stepwise create folded macromolecules making use of our well-known supramolecular units. These single chain nanoparticles with internal structure are now proposed to be the starting point for making compartmentalized three-dimensional systems that possess functionality similar to proteins. Therefore, also novel techniques to synthesize well-defined polymers are introduced.",From Supramolecular Polymers to Compartmentalized Systems,FP7,03 July 2017,04 January 2010,1947937.0 SUPRA-BIO,Brunel University,energy,"Economic and sustainable production of fuels, chemicals and materials from biomass requires capture of the maximum energy and monetary value from sustainable feedstock. SUPRA-BIO achieves this by focussing on innovative research and development of critical unit operations, by using process intensification to match economic production to the scale of available feedstock and by process integration that provides energy from process waste, optimises utilities to minimise environmental impact and maximises value from the product mix. A technology toolbox for conversion and separation operations is developed that adapts to various scenarios of product mix and feedstock. These are contextualized by full life cycle and economic analysis of potential biorefinery schemes. Based on lignocellulose, microbial/organic waste or microalgae feedstock, innovation and intensification are used to improve the economics and carbon efficiency of fractionation, separation, bio and thermochemical conversions to produce biofuels, intermediates and high value products. Strain selection, genetic manipulation, molecular design and nanocatalysis are used to improve productivity and selectivity; reactor design, intensification and utilities integration for economics. Fermentation to 2,3 butanediol is demonstrated. Mono and multiculture processes are researched for high value products and feedstock streams. Separation is developed for omega oils and specific lignochemicals. Nano and biocatalytic processes are developed for biofuels and bioactive molecules. Integration into potential biorefinery schemes is explored in laboratory pilots of integrated reactors, by piloting on sidestreams, by exchanging separated fractions between partners and by process evaluations. The project includes all the scientific, engineering and industrial skills required to produce the step changes required for biorefineries to impact significantly on realising the aims of the European Strategic Energy Technology Plan",Sustainable products from economic processing of biomass in highly integrated biorefineries,FP7,31 July 2014,01 February 2010,1.2318163E7 SUPRABIOMAT,University of Münster * Westfälische Wilhelms-Universität Münster,health,"Nanostructured functional materials are undoubtedly one of the main focal points in academic and industrial research communities. Nature's own 'bottom-up' strategy for the construction of immensely complex and sophisticated nanoscaled systems have served as an inspiration for ground-breaking developments in the field of supramolecular chemistry. I aim to combine self-assembly and self-organization for the fabrication of complex supramolecular systems with specific functionality. I propose to use peptide discotics for the controlled self-assembly of supramolecular functional nanoparticles in water and target molecular imaging studies in order to develop Supramolecular Biomedical Materials. I will establish a set of semi-empirical rules, a packing parameter, for the design of supramolecular colloidal particles. The strategy of frustrated growth will aim to balance out positive non-covalent interactions with repulsive forces. Thereby the growth, stability and biocompatible surface functionalisation of the architectures can be controlled, aiming at sizes below 20 nm. The resulting supramolecular materials will be applied in molecular imaging, the development of nanoparticulate targeted and multimodal contrast agents. The elegance and uniqueness of these Supramolecular Biomedical Materials is that following the initial targeting event, the self-assembled scaffolds will disassemble into their small building blocks. This optimises secretion by the renal system and at the same time, the highly 'effective' imaging is also retained because of the high local concentration of the imaging agent, thus enhancing overall contrast, sensitivity and resolution of for example cardiovascular disease processes. This will significantly reduce the residence times of the targeted agent, which is one of the major limitations in current biomedical applications using non-reversible nanoparticulate imaging.",Supramolecular Biomedical Materials,FP7,31 March 2016,01 April 2012,100000.0 SUPRACRYST,Consorzio per lo Sviluppo dei Sistemi a Grande Interfase,health,"Research towards 2D and 3D supramolecular crystal engineering is expected to play a key role in the development of controlled bottom-up fabrication of nanostructured devices. The ability to predict the self-assembly at different length scales, ultimately allowing to attain a full control over the interplay of kinetics and thermodynamics ruling the hierarchical self-assembly in inorganic and biological systems, is a fundamental prerequisite to the progress of the field. SUPRACRYST aims at contributing to the advance of such a central technological field in Europe, and in particular it will focus on the development of new DNA- and nanoparticle-based devices. The final goal will be the controlled engineering of 2D and 3D supramolecular crystals made of inorganic nanoparticles linked through the recognition of DNA single strands. The possibility of interfacing DNA with gold and magnetic nanoparticles, controlling both the geometry and the valence, will be explored. Structural DNA nanotechnology has opened up perspectives for the directed self-assembly of nanoparticles into patterned nanostructures that can lead to promising applications, such as photonic antennas and controlled plasmonic interactions. In this framework, the high-fidelity of DNA pairing code is exploited to program the assembly schemes, and single-stranded DNA (ss-DNA) will be used as couplings arms to steer the assembly of nano-units into functional 2D or 3D assemblies. The formation of ordered and disordered self-assembled condensed phases and their dependence on geometry and valence will be investigated. Controlling the length and flexibility of the binding DNA arms, as well as the architecture of the bonding pattern via the use of spacers and linkers, we aim to manipulate the obtained crystal structures and to tune the characteristic lattice spacing toward arrays of low nanoparticle density.",Self-Assembly of DNA-Functionalized Nanoparticles: a viable approach towards Supramolecular Crystals,FP7,31 October 2012,01 November 2009,45000.0 SUPRAFUNCTION,International Center for Research on the Frontiers of Chemistry * Centre International de Recherche aux Frontières de la Chimie,health,"SUPRAFUNCTION aims at mastering principles of supramolecular chemistry, in combination with top-down nanofabrication, to achieve a full control over the architecture vs. function relation in macromolecular materials for organic electronics, by analyzing and optimizing fundamental properties through which new capacities can emerge. Highly ordered supramolecularly engineered nanostructured materials (SENMs) will be self-assembled from conjugated 1D/2D molecules, and ultra-stiff multichromophoric arrays based on poly(isocyanides). Their interfaces with chemically functionalized top-down/bottom-up nanofabricated electrodes and with dielectrics will be tailored to reach SENM energy barriers with height <0.1eV and interface roughness of 3-7Ã…. Multiscale characterization of SENMs, nanoelectrodes and various interfaces will be done by Scanning Probe Microscopies, ultraviolet photoelectron spectroscopy and other methods, especially to quantitatively study 3 relevant properties, viz charge injection at interfaces, charge transfer, and photoswitching current through a molecular material. Prototypes of nanowires and Field-Effect Transistors (FETs) will be fabricated especially focusing on (1) unravelling charge transport vs. charge injection, (2) the effect of photo-doping in electron acceptor-donor dyad based SENMs, and (3) novel photo-switchable FETs based on either (i) photo-responsive azobenzene SAMs chemisorbed on electrodes/dielectrics to reversibly modulate the charge injection at interfaces, or (ii) electroactive SENMs of dithienylethenes featuring extended conjugation in the side arms to promote a light tuneable p-p stacking among adjacent molecules, ultimately affecting the charge transport in stacks. The generated knowledge will offer new solutions to nanoscale multifunctional organic based logic applications.",Supramolecular materials for organic electronics: unravelling the architecture vs. function relationship,FP7,31 March 2016,01 April 2011,1500000.0 SUPRANANOASSEMBLY,University of Bristol,manufacturing,"The development of nanostructured soft materials based on the solution self-assembly of polymers is an area of intense global interest. The self-assembly of semicrystalline-coil block copolymers is virtually unexplored but offers new opportunities to prepare well-defined micelles and enhances the opportunities to fabricate and manipulate novel nanostructures with tailored properties. This represents an important challenge for the successful exploitation of their potential for future technological applications ranging from stimuli-responsive nanoscaffolds to composite materials with improved functional characteristics. Recent advances in processing approaches using crystalline-coil systems with metalloblocks have provided new levels of tailorability to the self-assembled structures formed by block copolymer assemblies in solution. The generalization of this approach to other materials renders feasible the precise bottom-up formation of a broad range of unique functional nanostructures. As a result of the distinctive physical properties and functions of the constitutional components, diblock copolymers containing crystalline stereocomplexed polylactide or polycaprolactone segments will be studied as they provide an exciting opportunity to access novel hierarchically structured polymeric nanoobjects with predetermined properties.",Complex Supramolecular Architectures via the Micellization of Semicrystalline-Coil Block Copolymers: Synthesis and Hierarchical Self-Assembly,FP7,03 July 2015,04 January 2011,0.0 SUPRHAPOLYMERS,Queen Mary University of London,health,"Sugars and amino acids are natural building blocks which are used to form precisely regulated sequences in carbohydrates and proteins, respectively. While the field of proteomics has advanced immensely during the last past years, the field of glycomics is much less developed. The advance in synthetic polymer chemistry is allowing the possibility of controlling monomer sequences in synthetic macromolecules with diverse chemical structure providing many scientific and technological applications. 'SuprHApolymers' project aims to design and synthesize glycopolymers mimicking the composition and structure of hyaluronan (HA), a linear polysaccharide composed of repeating disaccharide units of N-acetyl-glucosamine (GlcNAc) and glucuronic acid (GlcUA), but with many important biological functions. Linear glycopolymers, made solely of GlcNAc or GlcUA sugars (homopolymers) or containing both sugars (copolymers) will be synthesized to study their interaction with synthetic peptides bearing HA-binding motifs (peptide library). The synthesis of HA-based glycopopymers with branched architecture will be also attempted to explore different polymer configurations and to create optimal interactions with peptides. The self-assembly of HA glycopolymers with peptide amphiphiles containing selected HA-binding sequences will be investigated to form de novo peptide-polymer hybrid supramolecular materials with different molecular and macroscopic properties. Finally, the formed functional assemblies (nanostructures and supramolecular gels or films) will be explored for applications in synthetic biology and biomedicine.",Engineering macromolecular self-assembly of hyaluronan (HA)-based glycopolymers with peptides,FP7,28 February 2018,01 March 2014,100000.0 SURFACE ENDOCYTOSIS,Heidelberg University * Ruprecht-Karls-Universität Heidelberg,health,"Cell-substrate interactions have a pronounced effect on cell attachment, growth and proliferation in healthy tissues and disease. The complexity of the in vivo setting has fueled in vitro studies on different aspects of cell behavior in response to different material properties. The proposed research project aims at establishing links between substrate properties and the fundamental process of endocytosis, on which limited knowledge currently exists. The use of mechanically and chemically defined, nano-patterned surfaces to probe the cellular mechanisms of regulation of different internalization pathways will be achieved through use of specialized cargoes, fluorescent labeling and imaging techniques. Strong emphasis will be placed on cancer cells, where both derailed endocytosis and abnormal extracellular matrix contribute to the disease. The combination of the researcher's strong background on endocytosis of nano structures and the host laboratory's expertise on surface fabrication and cell-surface interactions guarantee implementation of the project. The anticipated results will have a pronounced impact on our understanding of this fundamental cell process and are likely to be of technological interest in the fields of drug delivery and tissue engineering in the near future.",Effect of nano-patterned substrate properties on cell attachment and endocytosis,FP7,31 July 2012,01 August 2010,162661.0 SURFACET,Consejo Superior De Investigaciones Científicas (CSIC),health,"Biomaterials and drug delivery systems are complex composite systems, often made by applying organic solvents and additives, which have well-known disadvantages like toxicity and flammability. Furthermore, with increasing materials complexity and size reduction to nanoscale, classical solvent approaches are destructive because the used liquids destroy the functional surfaces they are helping to create, due to viscosity and surface tension. Technology based on supercritical carbon dioxide (SCCO2) is an alternative to overcome the problems associated with the use of traditional solvents. SCCO2 is a non-destructive solvent adequate to manipulate complex functional materials and nanostructures. Furthermore, the technology allows obtaining end-products free of residual solvents. SCCO2 technology is proposed here for the production of a great range of knowledge-based multifunctional materials with better control of surface properties and purity, and for the industrial - high-rate, high-volume - fabrication of surface hybridized or composite materials. The project is centered in pharmaceuticals (drug delivery and targeting with biomacromolecules), biomedical (tissue engineering) and cosmetics (ointmers) products prepared using this technology. Moreover, technology transfer to the plastics and fillers industries is addressed.",Sustainable Surface Technology for Multifunctional materials,FP6,31 May 2008,01 June 2005,1997225.0 SURFOIDS,University of Montpellier 2 Sciences et Techniques * Université Montpellier 2 Sciences et Techniques,manufacturing,"The ability to control regular spatial arrangements of particles is one of the central issues of the ‘‘bottom-up’’ approach to nanotechnology. Self-assembling of colloidal particles has arisen as a very hopeful alternative. However, these studies are typically performed in aqueous media where the interparticle interactions are poorly controlled. In this project we will study the interactions between particles trapped in a novel challenging interface consisting of a nematic liquid crystal and an isotropic fluid. Our fist objective is to exploit the unique properties of the nematic phase to achieve a high degree of control in the interaction of the particles trapped in the interface. In this geometry, the particle-particle interactions are triggered by capillary forces resulting from the interface distortion. We will employ electric/magnetic fields as well as sophisticated anchoring conditions for the nematic to tailor these distortions in terms of range, amplitude, and directionality. We will address questions concerning crystallization, melting and aggregation in a 2-dimensional space. To quantify the interface deformations we will use a technique based on Michelson interferometry and optical tweezers. Our second objective is to study the effect of particle anisotropy in the formation of ordered patterns. We will consider both spherical particles with anchoring gradients and particles with exotic geometry. Despite the richness of behavior expected, the relationship between the anisotropy of colloids and their collective behavior when trapped in an interface is still largely unknown. Finally, we will analyze how the behavior of the colloidal particles is affected by the interface curvature. Some elegant theoretical predictions show that equilibrium positions are located in the points of constant Gaussian curvature. This behavior is still completely unexplored experimentally and may find practical relevance in pickering emulsions, solid stabilized foams, etc.",Organization and self assembly of colloidal particles trapped on a Isotropic-Fluid/Liquid-Crystal Interface: Effects of particle anisotropy and interface curvature,FP7,12 July 2013,01 January 2010,168279.59 SURFPRO,Rijksuniversiteit Groningen * University of Groningen,information and communications technology,"Inspired by the possibility to create an artificial electronic band structure through the interplay of a molecular nanoporous network with the surface state electrons of a metallic substrate (recently reported by us), the utilization of this new concept for controlling the electronic surface properties of a material as well as establishing understanding of the underlying principles for the observed behavior is the overall aim of this project. The modification of the electronic surface properties also affects the material properties in general, such as conductivity, surface catalysis properties and reflectivity. Thus, the proposed concept has great potential for materials research and will ultimately result in the development of new materials with adjustable electronic properties. Such materials will find applications in e. g. (nano)electronic devices or sensors.",Tuning electronic surface properties by molecular patterning,FP7,12 July 2019,01 January 2013,0.0 SURFUNCELL,University of Graz * Karl-Franzens-Universität,health,"The projects main R&T objective is to create new, smart and bio-based surface nanostructured polymer composites showing exceptional surface functionality (mechanical, chemical, selective interaction properties). These new materials will be composed of nano-scaled polysaccharides layers with embedded nano-particles, coating different celluloses matrices. The compounding is restricted to the biopolymers surface and outer layers, providing the 'filler' to the area where it is required and avoiding the deterioration of the matrix materials mechanical properties. The project will investigate these new effects - cellulose dissolution, structuration with nano-particles and irreversible coating -will develop their understanding and mastering and exploit their applicability. Several routes will be opened to prepare a completely new class of high-value biobased materials with tailored functions and properties applicable in many different fields: • Separation technologies: providing selective interaction properties tuneable by environmental properties • Technical fibres and foils: Specific surface modifications (strength, abrasion, thermal and chemical stability, hydrophilicity/hydrophobicity …) • Improved properties as flame resistance, conductivity, antimicrobial activity, barrier properties • Medical and hygienic devices: Formation of depots for humidity, drugs (controlled release), antimicrobial compounds. • Sensors, displays, electronic devices: performing structural changes under the influence of an external field. The project will have impact to Nanoscience by the development of knowledge and new strategies to handle nanoparticles and to design multifunctional nanostructured composite materials based on renewable resources. Nanotechnology by the development of technologies to design new materials based on the elaborated scientifice knowledge.",Surface functionalisation of cellulose matrices using cellulose embedded nano-particles,FP7,30 November 2012,01 December 2008,5472795.0 SURFUND,University of Huddersfield,health,"This proposed project explores fundaments and principles for surface measurement and characterization for ultra/nano-precision non-Euclidean geometry and deterministic surfaces, which are vital for making possible key areas of 21st century science - pure and applied, engineering and bio-engineering. The research will explore an original integrated measurement and characterization system with two major aspects: (1) Characterization: to develop radical new thinking as to what are the fundamental building blocks of a texture-characterization system and apply that thinking to non-Euclidean and deterministic surfaces. It will explore necessary and sufficient mathematical operations and principles, surface decomposition models, distortion-free representation of texture etc. (2) Measurement: to investigate principles and enabling optical methods to on-line/in-line measurement for ultra/nano-precision non-Euclidean geometry and deterministic surfaces. The fruits of this research project will significantly facilitate surface-manufacturing control and functional performance of surfaces applied in 21st Century Science and Engineering over a wide set of sectors. Examples are surfaces used in optics and target shells in high-power laser-energy systems, optics in new earth/space-based large telescopes (e.g. the 42 m E-ELT telescope), interfaces in fluid-dynamics (energy-efficient jet engines, aircraft fuselages and wings), long-life human-joint implants, microelectronics and MEMS/NEMS devices in nanotechnology applications. The capability to perform surface quantitative measurements and characterization on the above key components does not exist today. This confronts the state-of-the-art in surface-measurement science with regard to new surface characteristics (structured or patterned surfaces), extremity of size (1 m - 2 m), ultra precision (1 in 10^9), quality, complexity of shape (non-Euclidean geometry), or combinations of these aspects.",Fundaments and Principles for Measurement and Characterization of 21st Century Science and Engineering Surfaces,FP7,31 December 2014,01 January 2009,1895152.0 SURMOF,Ruhr University Bochum * Ruhr-Universität Bochum,energy,"Control of growth and properties of structures on a length scale down to molecular dimensions is one of the major challenges in nanotechnology. The project tackles this challenge by merging surface science with coordination chemistry. Metal-organic frameworks (MOFs) which are coordination polymers consisting of organic ligands linked together by metal ions, are most promising systems due to the virtually unlimited flexibility in their design. Besides appealing properties of the MOF framework itself which makes MOFs most interesting as electrochromic, magnetic, and storage materials, it is the fact that the framework can be loaded with other molecular compounds by employing a guest-host chemistry. This possibility creates a tremendous technological potential in a variety of different fields, in particular with respect to catalysis and hydrogen storage. Further applications, e.g., in sensors and in electronics where the length scale below 20 nm requires solutions beyond established concepts, emerge when MOFs are attached to surfaces. Contrasting existing strategies which are based on the anchoring of bulk-synthesised MOFs on a surface, the present project takes a qualitatively new approach by using surfaces to initiate and control the growth of MOFs. Combining a bottom-up (building of the MOFs from molecular subunits) with a top-down (different types of lithographies) approach, control of MOF patterns in three dimensions is envisaged. Involving coordination and synthetic organic chemistry, surface science, and modelling a comprehensive approach is adopted. Ranging from fundamental aspects of nucleation and growth of MOFs to application related issues of their host-guest chemistry different schemes will be explored by experiments on different types of MOFs under conditions which range from ultrahigh vacuum to electrochemical environment.","Anchoring of metal-organic frameworks, MOFs, to surfaces",FP6,30 September 2009,01 October 2006,2500000.0 SURPASS,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),manufacturing,"The purpose of the restructured SURPASS project is to develop key technologies to achieve super-resolution beyond the diffraction limit in air at visible wavelength. The application fields covered by the project are optical data storage, wafer inspection, maskless optical lithography and confocal microscopy. The first super-resolution technology is based on so-called super-RENS materials (Super-Resolution Enhanced Near-Field Systems). These materials, such as the semiconductor InSb, undergo a local modification of their refractive index properties above a certain power threshold of a focused laser spot. As a consequence they produce a reduction of the effective size of the laser spot. Super-RENS materials are developed mainly for optical ROM discs to allow the readout of recorded marks smaller than the resolution limit of the optical readout system. The maximum capacity of single-level Super-RENS discs will be studied theoretically and experimentally. In parallel, semi-transparent Super-RENS levels will be developed and the industrial potential of this technology for multi-level discs will be evaluated. The purpose is to propose a technological solution for the extension of the Blu-Ray format from 25 GB to 75-100 GB for high-definition video content distribution. The second super-resolution technology is based on micro-solid immersion lenses (µ-SILs) which enable to reduce a focused laser spot by a factor equal to the refractive index of the µ-SIL. A low-cost manufacturing process will be developed on 200 mm silicon wafers. The resolution of µ-SIL should be further enhanced by using engineered polarization, high index material, plasmonic nanostructures at focus or functionalization with a Super-RENS layer. The performances of high-resolution optical heads including a µ-SIL will be studied in various application fields such as wafer inspection, optical lithography and confocal microscopy.",SUper-Resolution Photonics for Advanced Storage Systems,FP7,30 November 2011,01 June 2008,3448917.0 SUSNANO,University of Birmingham,energy,"Sustainable generation of energy is arguably the biggest challenge facing society. Investment into energy research is considerable (e.g. ~€2.5billion in EU FP7), with one key goal being the capture of solar energy. Production of electricity from sunlight (photovoltaics) is perhaps the most well-known option, but is restricted to less than 0.1% of the current market due to cost and problems with long term storage. An alternative approach, inspired by photosynthesis, is the use of sunlight to generate storable, transportable chemical fuels. These can include hydrocarbons from carbon dioxide and hydrogen from water splitting. While considerable advances have been made in artificial photosynthesis, efficient visible light catalysts are still a major challenge. Furthermore, any feasible large-scale system must be based on abundant materials and facile fabrication processes. This is emphasized in a recent White Paper prepared by the UK, US, Japanese, German and Chinese Chemical Societies. They state the need for, 'new catalysts and materials from low-cost, earth-abundant elements that can be used to build affordable, sustainable solar energy transformation and storage systems' This proposal will directly address this challenge by creating new photocatalyst/cocatalyst composites based on earth-abundant elements and facile methods. These unique approaches will enable H2 production in an economically viable and sustainable manner.",Sustainable Nanocomposites for Photocatalysis,FP7,30 September 2017,01 October 2013,100000.0 SUSTAINCOMP,Innventia AB,health,"The SustainComp project aims at the development of a series of completely new wood-based sustainable composite materials for use in a wide array of market sectors, ranging from the medical, transportation and packaging to the construction sector. A primary goal is to substitute fossil-based materials used in these sectors. The performance of today's biocomposite materials is not sufficient for a range of applications. The approach is to better utilize the inherent properties of cellulosic fibres and nanocellulose fibrils in such materials. The project encompasses the whole chain from production of modified fibres and nanocellulose through compounding and moulding to the final ecodesigned product for a number of product families. These new materials will integrate today's large enterprises on the raw material and end-use sides (e.g. pulp mills and packaging manufacturers) and small and medium sized enterprises on the composite processing side (e.g. compounders and composite manufacturers). It is envisioned that this will help the transformation of the traditional Forest Products Industry to more highly value added materials through the adaption of a set of advanced technologies such as the production of nanocellulose in larger scale, tailoring of fibres and nanocellulose, wet commingling, nanostructuring, layer by layer deposition and fibre spinning using nanocellulose fibrils. More specifically the objective is to demonstrate new products within the following product families: i) Nano-reinforced foams (to replace styrofoams in the packaging and construction sector) ii) Moulded type of compounds, to introduce cellulose reinforced renewable biocomposites in the transportation and construction sectors iii) High throughput nanostructured membranes with designed selectivity for small-scale liquid applications in the medical field to large scale municipal applications This project conforms to the envisioned composite program in the Forest Technology Platform.",Development of Sustainable Composite Materials,FP7,31 August 2012,01 September 2008,6500000.0 SWIFT,IMEP-LAHC Laboratory,photonics,"This proposal focuses on the design, fabrication, characterization and optimization of novel groundbreaking communication nano-devices. SWIFT proposes resolutely innovative concepts adopting metal-based optical nano-antennas as a disruptive technological vehicle. Nanoscale electronics and photonics exploit novel fascinating physical phenomena and are among the most promising research areas for providing functional nano-components for data transfer and processing. The aim of this proposal is to interface these two device-generating technologies to create the first electrically-driven nanoscale optical antenna transceiver. The concept will enable electron/photon transduction at the nanoscale by a unique surface plasmon-assisted metal-based design, a significant leap at the forefront of research in nanoelectronics and nanophotonics. SWIFT proposes a series of fundamental advances motivated by application-driven perspectives that will push the burgeoning field of optical antenna to a new area. Deploying optical antenna transceivers enables a paradigm shift in optical interconnects and communication at ultimate device densities through the following innovations: • Development a whole new class of plasmon-assisted transducing optical functional nanodevices.This unique concept addresses the development for ultracompact nanocomponents. • Prototyping self-sustained plasmonic in/out electrical ports on SPP waveguiding platforms, removing thus complex optical interfacing that cannot be miniaturized. • Pioneering a technological breakthrough enabling nanoscale wireless broadcasting of optical information. • Using these functionalities, we will prospect new research directions by proviing a unique ground for (i) generating ultrafast electron surges in an integrated electronic layout enabling ultrafast transport studies in molecular electronics and (ii) for realizing ultrasmall THz sources enabling thus penetration of THz technology at the nanometer-scale.",Surface Plasmon-Based Wifi for Nanoscale Optical Information Transport - SWIFT,FP7,31 January 2018,01 February 2013,1495288.0 SWIMSYNTHETIC,University of Cambridge,health,"The future of medicine requires the development of novel devices and methods enabling detection, diagnosis, and treatment of diseases. These tasks, especially targeted therapy and diagnostics, could be achieved through the action of synthetic self-propelled swimmers at the micrometer and nanometer scale. In this project, I combine two of the thematic areas from the 7th framework program (health and nanosciences) and propose to conduct theoretical studies to discover the physical principles behind such artificially-propelled small-scale swimmers in complex fluids. Specifically I propose to quantify the dynamics and stability of artificial swimmers driven by magnetic or acoustic fields, model the dynamics of synthetic swimmers in complex fluids as relevant to the biomedical world, and derive a mathematical framework quantifying the role of stochastic forces on the dynamics of artificial swimmers. The research approach is fundamental and consists of theoretical and computational studies purposely positioned upstream of experiments. The ultimate goal of this project is to advance our knowledge in the fundamental physical principles of small-scale locomotion while deriving the guiding principles necessary to design of a wide class of artificial swimmers for use in biomedicine. The support of the CIG will allow me to return to Europe after a productive 12-year academic career in the United States; provide a financial support for my research activities in an outstanding scientific environment (the University of Cambridge); enable the communication of my past expertise and the knowledge acquired during the project to my immediate environment and broadly in the European Union; establish new collaborations in Europe; build on my track record in teaching by educating European students; reach the general public through extensive outreach efforts; and encourage further research in the development of novel nanotechnologies relevant to the future of healthcare in Europe.",Physics of synthetic small-scale propulsion in complex fluids for biomedical applications,FP7,31 July 2017,01 August 2013,100000.0 SWITCHROM,University of Manchester,information and communications technology,"The inherent limitations of current semiconductor-based electronics regarding speed, scale and mode of operation have inspired much research in molecular electronics and photonics. Within this broad scientific field, nonlinear optical (NLO) and liquid crystalline materials are especially interesting. NLO effects allow the manipulation of laser light beams and can be used in electro-optical data processing, and also revolutionary all-optical technologies. Simple organic liquid crystals (LCs) have long proved useful, for example in display devices. We propose to synthesise two new classes of organotransition metal compounds designed to show very large NLO effects. The first group comprises amphiphilic ruthenium complex salts which are intended to form Langmuir-Blodgett (LB) or related thin films displaying bulk NLO behaviour. By depositing such films onto optically transparent electrodes, we aim to achieve the first convincing demonstration of reversible switching of optical properties via metal-based redox. The second group of target compounds are neutral ruthenium complexes that are expected to form LC phases. All new compounds will be fully characterised in-house using standard techniques including NMR and UV-visible spectroscopy and electrochemistry. The project also involves collaborations with leading research groups in Europe and the USA. Molecular optical and electronic properties will be measured in Leuven (Belgium) using hyper-Rayleigh scattering, and using Stark spectroscopy at the California Institute of Technology (USA). Various advanced calculations including time-dependent density functional methods will also be pursued with experts in Zaragoza (Spain). LB or related thin films will be fabricated in Leuven, and LC behaviour will be investigated locally with specialists in physics. This work is driven primarily by scientific curiosity, but the long-term goal is to create new materials which may be useful in future optical data processing devices.",Redox-Switchable Nonlinear Optical Metallochromophores: Towards Functional Materials,FP6,31 October 2007,01 November 2006,168231.96 SYBHEL,University of Bristol,health,"Synthetic Biology (SynBio) is a relatively new field of scientific endeavour. Rather than seeking to understand living organisms, SynBio researchers aim to design and build entirely new living systems at the molecular, cellular, tissue and organism level. SynBio uses methods and tools from many disciplines, notably engineering, genetics, biotechnology and biochemistry; but also nanotechnology, physics and computational modelling. A key attribute is the use of principles of engineering with components from the life sciences to build or exploit living organisms rather than machines. Applications of SynBio research include environmental and health benefits, for example bio-fuels, biosensors and therapeutics. Researchers in SynBio are keen to address the ethical, legal and social aspects of their work. To date, however, ELSI considerations of SynBio have targeted safety and regulatory aspects of the field as a whole. No studies have focussed specifically on the ethical implications of SynBio for human health. The SYBHEL project will address this gap to provide the first detailed analysis of one of the key global applications of SynBio. SYBHEL will examine several aspects of SynBio as it applies to human health including: philosophical and social understandings of life (including new human-like entities); appropriate methodology for bioethical analysis in SynBio for health; ethical issues arising in utilising SynBio for health; regulatory and commercial aspects and public policy in SynBio for health care. The RTD work-packages will be underscored by several cross-cutting themes to ensure maximum flexibility and relevance of outcomes. SYBHEL will therefore be informed by existing work on: the definition and scientific state of the art of SynBio; safety aspects and issues of distributive justice. SYBHEL will adopt an approach that recognises the non-reductionist, non-essentialist, dynamic and integrative nature of SynBio and will develop a comparable ethics response.",Synthetic Biology for Human Health: Ethical and Legal Issues,FP7,30 September 2012,01 October 2009,803587.0 SYLO,Budapest University of Technology and Economics * Budapesti Műszaki és Gazdaságtudományi Egyetem,photonics,"Sustainable development in information technology calls for an ever increasing information processing and storage capability. A promising route to maintain exponential growth capability, i.e. to keep on the Moore's roadmap, is to turn to the electron spins as information carriers rather than their charge. This field, spintronics, has enormous potential whose exploitation requires solid knowledge in the fundamentals of spin dynamics and spin transport. Herein, novel nanomaterials are suggested for spintronics purposes, such as graphene and single-wall carbon nanotubes (SWCNTs). These, fundamental two- and one-dimensional carbon allotropes are promising candidates for such purposes, carbon being a light element with a low spin-orbit coupling which results in a long spin coherence. There are several fundamental open issues, e.g. the dominant spin orbit coupling mechanism in graphene, whether bulk electron spin resonance can be observed for this material, and the length of the spin diffusion length. For SWCNTs, the ground state of isolated metallic tubes is known to be the Tomonaga-Luttinger liquid (TLL), which greatly limit the spin coherence, but it is at present open whether this state is destroyed when an ensemble of interacting metallic tubes is studied. The decay time and spin symmetry of optical excitations (excitons) in semiconducting SWCNTs is yet unknown. Our goal is to pursue electron spin resonance in graphene and carbon nanotubes and to perform optically detected magnetic resonance in carbon nanotubes. We will commission a magnetoptical spectrometer with a substantial added value. The expected results are characterization of spin transport capabilities of these materials and understanding of the spin decoherence mechanisms. The PI leads magnetic resonance studies of these materials, shown by his more than 300 citations to this field (the total being over 470) and his 15 Physical Review Letters papers in this field (of which for 9 he is main Author).",Spin dynamics and transport at the quantum edge in low dimensional nanomaterials,FP7,31 October 2015,01 November 2010,1230000.0 SYMBIOSIS-EU,Agricultural University of Athens,health,"The SYMBIOSIS-EU project will bring together 14 partners from 6 EU countries (plus one each from NZ and US) to study meat safety & quality. The overall aim is to identify and quantitatively evaluate practical and easy to use chemical, biochemical and molecular indices and establish their applicability as quality monitors for inspection of meat safety and quality. The project will apply a multidisciplinary system-wide approach relying on converging technologies (bioinformatics, nanotechnology, modelling) to obtain knowledge for meat safety that will be translated into simple devices and practical indicators of quality and safety. The main objectives are (i) to develop and/or validate easy to use chemical/biochemical methods (e.g. biosensors, fluorescence, FT-IR), molecular methods (DNA microarrays), (ii) to develop a suitable software platform for data sharing and integration, (iii) to apply multivariate statistical methods and machine learning (neural networks, fuzzy logic, genetic algorithms) to identify robust multiple compound quality indices, (iv) integration of the sensors and information platform and development of a system to automatically transform data acquired from a sample into a 'diagnosis' of meat safety and quality. The project plan designed to meet these objectives comprises 3 Sections: 1 Microbial status and their major metabolomic, molecular profiling of spoilage bacteria, 2. Development of an easy to use integrated system to monitor meat safety and quality 3. Development of protocols for simple, effective and cheap evaluation of meat quality and safety in industry, based on new indices of quality and safety relying on detection of metabolites by simple sensors, driven by user friendly software that facilitates practical use of the developed methods. The project will be of benefit to the EU meat industry, providing useful tools and fundamental knowledge of the spoilage and hazard. It will also impact on the research and informatics communities.","Scientific sYnergisM of nano-Bio-Info-cOgni Science for an Integrated system to monitor meat quality and Safety during production, storage, and distribution in EU",FP7,31 March 2012,01 October 2008,2280098.0 SYMONE,Chalmers University of Technology * Chalmers Tekniska Högskola,information and communications technology,"The SYMONE long-term vision is to build multi-scale bio-/neuro-inspired systems interfacing/connecting molecular-scale devices to macroscopic systems for unconventional information processing with scalable neuromorphic architectures. The SYMONE computational substrate is a memristive/synaptic network controlled by a multi-terminal structure of input/output ports and internal gates embedded in a classical digital CMOS environment. The SYMONE goal is the exploration of a multiscale platform connecting molecular-scale devices into networks for the development and testing of synaptic devices and scalable neuromorphic architectures, and for investigating materials and components with new functionalities. The generic breakthrough concerns proof-of-concept of unconventional information processing involving flow of information via short-range interactions through a network of non-linear elements: switches, memristors/synapses. These will require several breakthroughs concerning the functionality of reasonably complex networks of simple components, and the fabrication of networks of devices, including self-assembly and multi-scale interfacing/contacting between such networks.",SYnaptic MOlecular NEtworks for Bio-inspired Information Processing,FP7,08 July 2017,09 January 2012,0.0 SYNABCO,Aston University,energy,"SYNABCO will increase the efficiency and lifetime of organic solar cells (OSCs) by creating a highly original and industrially viable polymer layer which will bind critical components together within the device. Finding an inexpensive, clean and completely renewable energy source is the most pressing challenge of current times. OSCs offer superb potential to meet this challenge but are currently not able to do so because they are inefficient and lack long term stability. It is critical that the technological break-through required to bring solar energy to every household across the world is explored while we are still in a position to do so. The scientific goal of SYNABCO is to provide just such a step-change technology platform. SYNABCOs multidisciplinary solution will exploit polymer nanotechnology and so although it will be 'smart' it will also be cheap and readily scaleable. Moreover, as it will be developed in concert with Konarka, the largest manufacturer of OSCs in the world, it will be immediately applicable in a global marketplace. The IP, papers and seminars that result from SYNABCO will also help maintain the EU as a leading centre for both academic and industrial research into OSCs. SYNABCO will also provide a unique training opportunity to develop a highly skilled fellow with broad OSC-relevant scientific skill and knowledge sets. The SYNABCO fellow will additionally receive training in a broad range of complementary skills. The training, skills and knowledge base with which SYNABCO will imbue the fellow will ensure that upon successfully completing the project he will be capable of becoming a leading research figure in OSCs within the EU. The ERA will thus reap considerable benefit from the development of an independent and mature researcher with a truly transnational background who will be able to contribute a significant and long term research effort into a pivotal area of research in which it is vital that the EU remains at the forefront.",Synthesis and Application of Block Copolymers for Interfacial Stability in Organic Solar Cells,FP7,31 August 2013,01 September 2011,209092.0 SYNAPSE,National Research Council * Consiglio Nazionale delle Ricerche (CNR),transport,,SYnthesis and functionality of chalcogenide NAnostructures,FP7,11 June 2017,12 January 2012,0.0 SYNAPTIC,STMicroelectronics Srl,information and communications technology,"This proposal addresses Objective ICT-2009.3.2: “Design of Semiconductor Components and Electronic Based Miniaturized Systems” by development of “methods and tools to cope with the design challenges in the next generations of technologies” and focuses on the objective “design for manufacturability taking into account increased variability of new processes”. The project described in this proposal targets the optimization of manufacturability and the reduction of systematic variations in nanometer technologies through exploitation of regularity at the architectural, structural, and geometrical levels. We propose the creation of a methodology and associated suite of design tools which extract regularity at the architectural and structural level and automate the creation of regular compound cells which implement the functionality of the extracted templates. The cell creation will employ Restricted Design Rules (RDR’s) and other regularity techniques at the geometrical level to maximize manufacturability and reduce systematic variations. Since the majority of designs in the nanometer regime employ some form of SRAM the project will include a study of the effects of RDR’s on SRAM in terms of performance and manufacturability and the subsequent definition of a set of RDR’s which allow manufacturability optimization for logic functions while remaining compatible with SRAM technologies. To this end we have assembled a consortium of European academic, research and industrial experts with world class experience in regularity approaches at the various levels. In order to ensure the successful commercialization and deployment of the resulting tool suite the consortium includes a European EDA vendor with significant expertise in the field of design optimization through automated cell creation. This project will enable European industry to play a leading role in the definition of next generation design methodologies and challenge the US domination in the area of design automation.","SYNthesis using Advanced Process Technology Integrated in regular Cells, IPs, architectures, and design platforms",FP7,02 January 2013,11 February 2009,3520000.0 SYNBIOSIS,"JIC, zájmové sdružení právnických osob",construction,"The main objective of SyBIOsys project is to pull together two research-driven clusters in the field covering the intersection of biotechnology/life science and ICT, more specifically, in the domains of bioinformatics, nanobio, computational biology and biomedicine. The two partner regions – South Moravia (CZ) and Friuli-Venezia-Giulia (IT) - share an interest in this particular research domain and also an interest in developing unique research infrastructures for this domain. While the Italian region has an existing unique research infrastructure in place (AREA Science Park with the Free Electron Laser, a part of ESFRI Road Map), South Moravia is in the process of designing its new research infrastructure and plans to fund it primarily from the EU Structural Funds. The focus of the project is thus on the valorisation of research infrastructure in these regions and strengthening collaboration with business sector. Emphasis is laid on collaboration, search for complementarities, synergies with activities of the Structural Funds, and on exploiting the experience of other EU regions in respect of opening up research infrastructures to collaboration with business sector. Mentoring will be used as an instrument that will especially contribute to a better design of the newly built infrastructure in South Moravia and, in case of both partner regions, to increase the economic relevance of research infrastructures and their tighter integration with the local economy. Simultaneously, emphasis will be laid on developing partnerships with other regions in the EU with a similar profile and interest with a special emphasis on the Central European region. The project aims, as a part of its activities, to enrol not only stakeholders in the two partner regions, but also to extend the network to the geographically proximate regions (Vienna/Austria, Bratislava/Slovakia, Ljubljana/Slovenia) with a view to share the experience and seek complementarities in research infrastructures.",Maximizing Synergies for Central European Biotech Research Infrastructures,FP7,08 July 2014,09 January 2009,938955.0 SYNINTER,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"We aim to design smart substrates and suitable detection techniques to understand better the dynamics and spatial organization found in the immunological synapse, with the ultimate goal of developing new diagnostic tools for sensitive detection of immune deficiency diseases that arise from faulty adhesion. The immunological synapse (IS), formed at the interface between a T-lymphocyte and an antigen presenting cell, has been the target of intense multidisciplinary research in the last decade. Studies point to a crucial role for adhesion mediated by protein clusters for the stability and activity of the synapse. However, even the cluster size - micro or nano scale - remains contentious. Furthermore, while in vivo, the synapse is formed in a soft 3D environment, most in vitro experiments are on hard 2D surfaces. Clearly, one way to probe how the micro/nano environment of the T-cell influences the IS is by interrogating it with artificial substrates that are soft, three dimensionally structured and exhibit motifs down to the cluster length-scale. We shall develop 3D and soft polymeric structures with controlled placement of adhesion molecules and antigens on a single molecule level. The structure, assembly and signalling for stable as well as dynamic IS, on such substrates, will be investigated. Mechano-transduction at IS will be probed by using soft substrates of tunable Youngs modulus. Advanced optical techniques will be developed for quantitative and dynamic mapping of proteins and the cell-cell interface topography. Quantitative reflection interference contrast microscopy, will permit characterization of adhesion of native cells without the need of a special labelling strategy. Our advanced substrates and observation techniques will open up new ways to probe inter-cellular adhesion in general and the immunological synapse in particular. The acquired knowledge will be used for fabricating a cell sensor device for diagnosing T-cell pathology.",Smart interrogation of the immune synapse by nano-patterned and soft 3D substrates,FP7,31 December 2017,01 January 2013,1133565.0 SYNQPSK,University of Paderborn * Universität Paderborn,information and communications technology,"Synchronous quadrature phase shift keying (QPSK) transmission combined with return-to-zero (RZ) coding and polarization division multiplex is an extremely attractive modulation format for metropolitan area and long haul fiber communication. Compared to standard intensity modulation the line rate is 4 times lower, the needed number of photons per bit less than half as high, the tolerance to chromatic dispersion about 8 times better, the tolerance to polarization mode dispersion about 3 times better, and the tolerance against fiber nonlinearities, in particular cross phase modulation, is excellent. Moreover, all linear optical distortions (polarization transformations, polarization mode dispersion, chromatic dispersion) can be equalized without losses in the electrical domain. Distinct advantages exist also over all other modulation formats, including duobinary, DPSK and DQPSK. So far, synchronous QPSK has not been realized because the necessary components were not available, for example lasers with linewidths in the lower kHz region. For the implementation of synchronous RZ-QPSK transmission with polarization division multiplex this project aims at the realization of all necessary components which can not be found on the market: LiNbO3 QPSK modulators in the transmitter, LiNbO3 optical 90� hybrids, InP balanced photoreceivers - reliably co-packaged with the 90� hybrids - and SiGe/CMOS integrated electronic circuits for signal conditioning in the receiver. Standard distributed-feedback (DFB) lasers are tolerable for signal and local oscillator lasers due to a novel carrier recovery concept that requires no phase-locked loop. It is implemented in the receiver by analog-to-digital conversion and subsequent CMOS signal processing. The symbol rate is 10 Gsymbols/s which amounts to 40 Gbit/s, plus FEC overhead. All components and contributions shall be validated in a synchronous QPSK polarization division multiplex transmission testbed.",Components for synchronous optical quadrature phase shift keyingtransmission,FP6,30 June 2008,30 June 2004,1695000.0 SYNTHAFLEECE,Fraunhofer Society for the Advancement of Applied Research * Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eV,health,"The SME Participants in the SynthaFleece project (NANOVAL, BBS, ASTERIE, STERIPACK) aim to create a new, totally synthetic medical device based on a poly-lactide (PLA) polymer platform that is capable of the sustained release of ionic silver, antibiotics and bone morphogenetic proteins (BMPs) whist stimulating haemostasis and encouraging bone growth and healing. With such a device we can target the market for healing of potentially infected wounds arising from bone and joint surgery worth in excess of €220 million in 2007. To achieve our objective we need to develop new scientific knowledge in: PLA polymer technology and in particular the creation of high density fleece materials for the release of active agents; how the variation of polymer density in a spun-bonded fleece can modify the release characteristics of silver ions, antibiotics and BMPs; the basis for physical and/or chemical induction of haemostasis; and to translate this knowledge into creation of PLA-based micro-fibres to be spun-bonded into a fleece that can bind silver ions, antibiotics and BMPs and release them over a period from seven days to two weeks. The fleece should degrade in the wound bed and be absorbed over the same time period whilst causing immediate and long-lasting haemostasis. Whilst the SMEPs form a complete supply chain for the manufacture of the ultimate fleece product we have neither the facilities nor the resources to undertake the necessary R&D. The Research for SMEs funding instrument provides the ideal solution allowing us to outsource the R&D to three RTD Performers -FhG, HERI and IMM-recherche. The Foreground Intellectual Property (FGIP) generated in the SynthaFleece project will be owned by the SMEPs and exploited in partnership with a large enterprise (BIOMET) which will provide a route to the global market for wound-healing devices. The SMEPs will benefit from sales and licensing of the FGIP to the tune of €XXX million over a ten year period.","Creation of a synthetic, absorbable, haemostatic fleece for delivery of active agents into healing wounds",FP7,31 May 2011,01 September 2008,1017918.0 SYNTORBMAG,University of Duisburg-Essen * Universität Duisburg-Essen,health,"Monodisperse magnetic nanoparticles (3 -200 nm) have a huge potential for applications in medicine like tumor therapy, gene sequencing, contrast agents in magnetic imaging, bio-labeling, or drug delivery agents and also in information technology relevant areas like non-volatile data storage and sensor applications. Most of the magnetic nanoparticles have the disadvantage of either being bio-incompatible or not thermally stable due to too small a magnetic anisotropy energy. The goal of the network is to synthesize and characterize new types of core shell particles (in the size range between 3 and 200 nm) consisting of a magnetic core with a large magnetic anisotropy (e.g. FePt , CoSm) protected by an inert, bio-compatible shell of few atomic layers of noble metals (Au, Ag ,Pt) or iron oxides.. Atomic layer control over the shell thickness and the core diameter shall be achieved. The new combination of ferromagnetic core (3d metal) and ferrimagnetic shell materials (e.g. 4f metals or oxides) will yield high coercive nanoparticles which can be used as building blocks for novel magnetic materials. The complex interface and surface magnetism of individual nanoparticles which are unique in terms of their high surface-to-volume and interface-to-volume ratio (r=0.2 to 0.5), will be investigated by ferro-/paramagnetic resonance and magnetic circular dichroism, which allows the determination of element specific magnetic moments and the distinction of orbital contributions from the core, the interfaces or the surface. The results of this basic research will provide a better understanding for the functionalization of the interface properties which control the response of magnetic sensors exchange bias) or the compatibility to medical applications. The added benefit is the focus on the interdisciplinary training in organochemical synthesis of complex nanoparticles, the work at large synchrotron user facilities using unique magnetic and chemical characterization technique",Synthesis an Orbital magnetism of core-shell nanoparticles,FP6,31 October 2008,01 November 2004,1448326.0 SYSAFEBION,Stichting Katholieke Universiteit * Catholic University Foundation,manufacturing,"The aim of the proposed research is to construct and study new amphiphilic architectures built from the ferritin protein cage as a hydrophilic headgroup and a single synthetic polymer as the hydrophobic tail. These so-called giant amphiphiles have been prepared before in the host group using single enzymes as the headgroup. However, the use of an intact protein cage is novel and no such structures have been reported in the literature. The aimed biohybrid polymer/protein architecture is even bigger than the giant amphiphiles studied so far, and the use of the ferritin cavity opens the way to introduce different functionalities (e.g. catalysts). Ferritin is particularly suited for this purpose as it is monodisperse and robust, and furthermore its demetallated analogue (apo-ferritin) can be used to encase a variety of inorganic potentially catalytic compounds, i.e. forming a self-assembling nanoreactor. The project consist of three work packages: 1) The first one will focus on the modification of the (apo-)ferritin with synthetic polymers. A single attachment point on the protein mantle will be introduced to which a polymer can be coupled or to use it as an initiator to grow a polymer from the nanometer sized bio-particle. 2) In work package 2 a detailed study of the self-assembling properties of the novel amphiphilic protein/polymer biohybrids will be carried out. The aggregation process will be studied by a variety of procedures such as spectroscopic studies, calorimetry, microscopy and scattering techniques. 3) In the final work package the potential application of the apo-ferritin protein cage as a nanoreactor will be investigated. Catalytic (inorganic) compounds can be introduced in this cavity, and assembling amphiphiles including different catalysts may eventually lead to a mimic of natural multi-enzyme systems. These complex architectures may be able to carry out a cascade of reactions in which the product of a reaction is the substrate for the next one.",Synthesis and Self-Assembly of Ferritin-Based Novel Biohybrid Nanoparticles,FP6,31 December 2008,01 January 2007,149276.0 T3NET,University Medical Center Hamburg-Eppendorf * Universitätsklinikum Hamburg-Eppendorf,health,"Cardiovascular and cancer-related diseases are the leading causes of human mortality and disability. The underlying mechanisms originate from chronic interstitial cell activation leading to pathological tissue remodelling and malfunction of cells. These depend on three fundamental processes: cell adhesion, migration, and modulation/degradation of the extracellular matrix (ECM), which together determine tissue invasion and remodelling. The proposed ITN Tissue Transmigration Training Network (T3Net) is aimed at promoting excellence in training in these areas, with an emphasis on cutting-edge technologies and complementary skills training. T3Net is very timely and has a multidisciplinary training approach unavailable within a single country of the EU. T3Net will be crucial in bundling current and future European expertise and to thus consolidate the momentary European leadership in these emerging key areas of biomedical research. The academic and industrial partners will provide training in new areas of research including the cell structures mediating invasion such as podosomes and invadopodia, as well as the application of materials sciences, nanotechnology and state-of-the-art in vivo imaging. These techniques will be applied to study ECM-cell interactions, in models encompassing vascular remodelling, immunity, inflammation and bone physiology, as well as the pathophysiology of cancer invasion. T3Net trainees will thus be at the forefront of current research, with innovative, complementary expertise in ECM remodelling and tissue transmigration in physiology and pathology. They will also benefit from valuable complementary skills training including communication, entrepreneurship and intellectual property rights. The strength and appeal of the T3Net proposal thus lies in the unique prospect to establish a long-term European network based on a new cohort of young professionals with the potential to exploit their knowledge in academic, clinical or industrial settings.",Tissue Transmigration Training Network,FP7,31 August 2013,01 September 2009,2857635.0 TAILPHOX,Polytechnic University of Valencia * Universitat Politècnica de València,photonics,"TAILPHOX project addresses the design and implementation of Silicon phoXonic crystal structures that allow a simultaneous control of both photonic and phononic waves. The final goal is to push the performance of optical devices well beyond the state of the art by this radically new approach. By merging both fields (nanophotonics and nanophononics) within a same platform, novel unprecedented control of light and sound in very small regions will be achieved. The project will cover from the development of theoretical and numerical tools to deal simultaneously with light and sound to the application to three high-impact scenarios in the field of ICT: i) phonon-assisted light emission in Silicon, ii) control of photon speed (delay and storage) by SBS in Silicon photonic chips, and iii) realization of highly-sensitive dual phoXonic sensors.",TAILoring photon-phonon interaction in silicon PHOXonic crystals,FP7,30 October 2012,01 May 2009,2111088.0 TANOGAPPS,University of Bristol,photonics,"The overarching aim of the proposed research is to advance the understanding and design of conjugated oligomeric materials with tunable optoelectronic properties, in particular materials based on oligo(aniline)s, for applications in the EU priority area of organic electronics. To underpin and support this innovation, key new routes to novel molecular architectures and nanostructures will be explored. The proposed research deals with the designed synthesis of a library of nanostructures based on star-like oligo(aniline)s from the Buchwald-Hartwig cross-coupling strategy and ionic self-assembly technique. Controlling the molecular architecture and acids dopants will allow for tuning of and controll over band gaps, physical dimensions and localized defects. This approach will lead to optimised nanostructured morphologies and ensure efficient charge separation and transport. As a result, enhanced mobility, sensitivity and selective interactions with external stimuli will offer smart nanomaterials for gas sensors. The project will open unexplored avenues in this priority area of organic electronics through its inter- and multidisciplinary approach, i.e., the proposed research will rely on modern synthetic organic chemistry, chemicophysical analyses of optoelectronic properties and structure relationships, self-assembly in the solid state, device fabrication and testing. It is expected that the outcomes of this proposed research will substantially impact across and beyond the mentioned range of disciplines. This project will therefore 1) aid in continuing to establish European excellence and competitiveness in the field of organic electronics, a priority research area in the European Research Area, and 2) is expected to accelerate the development of selective and tunable sensors, which will have major impact on ERA scientific communities, public health and EU security.",Star-like Oligo(aniline)s with Tunable Band Gaps for Tailored Nanostructures in Advanced Electronic Applications,FP7,28 July 2015,29 July 2013,231283.0 TAQUS,Cardiff University,photonics,Self-assembled semiconductor quantum structures are the subject of world-wide interest because of their potential use in quantum information technologies and nanoscale optoelectronics. This project will advance this field by obtaining nanoscale movies of III-V quantum structure formation. This will be achieved by establishing a € 1 million Low Energy Electron Microscope (LEEM) which is the only instrument in the world capable of obtaining nanoscale movies of compound semiconductor growth under arsenic flux. The understanding gained from this work will facilitate a new level of control over specific quantum features for device applications.,Tailored Quantum Structures,FP7,31 May 2015,01 June 2013,309235.0 TARCC,National Institute of Health and Medical Research * Institut National de la Santé et de la Recherche Médicale (INSERM),health,"This project aims at improving drug delivery to cancer cells by developing targeted radiotherapy with alpha-emitting radionuclides. Alpha particles emitted by radionuclides have short tracks (about 100 microns) in body tissues. As a result, they should be most appropriate to treat small-size tumours and isolated cancer cells. This project proposes the development of improved vectors and targeting technology based on specific targeting agents (recombinant antibody fragments and synthetic peptides), pretargeting approaches and nano-colloids especially designed to deliver alpha-emitting radionuclides to cancer cells after local or systemic administration. The concept of in situ generator, that allows the use of longer half-life parents of alpha-emitting radionuclides will be developed. Several approaches to prevent the release of radionuclides after parent isotope disintegration, including encapsulation in nano-colloids, are proposed. Improved targeting methods will be tested in animal models of small-size tumours and associated dosimetry (including micro-dosimetry) and toxicity studies will be performed. The final goal of the project will be to propose one or several new products for targeted delivery of alpha-emitting radionuclides for clinical development.",Targeting alpha-particle emitting radionuclides to combat cancer,FP7,30 June 2011,01 January 2008,3000000.0 TARGET,FTW Research Center for Telecommunications Wien Betriebs * FTW Forschungszentrum Telekommunikation Wien Betriebs-GmbH,information and communications technology,"The aim of TARGET is to overcome the fragmentation of European research in the field of microwave power amplifiers for broadband wireless access by creating a progressive and durable integration of research capacities of the network partners. Ultimately, European technology and research in the fields of active power devices beyond CMOS, of the characterisation and simulation of materials and devices, of amplifier design and linearisation, and in the field of broadband transmitter system design shall attain a leading role in the world. This challenge has been rightly acknowledged by the European Commission in making 'Pushing the limits of CMOS and preparing for Post-CMOS' a strategic objective of the IST work programme 2003-2004.TARGET will bring together 45 top amplifier research groups consisting of 168 researchers and 67 doctoral students (coming from 12 EU member countries, 3 candidate countries, and 2 associated countries) that have in the past three years published more than 1000 papers. This integration will be pursued with the aim to - create a co-operative network- establish a virtual centre of excellence- stimulate and co-ordinate world-class research.TARGET will follow a well-designed methodology to integrate research in this field. As a general principle, it will use research itself for the purpose of achieving a desire to integrate among the participants. A total of 26 work packages in the fields of integration, joint research, dissemination of knowledge, and of network management are defined for the first 18 month period. To account for the special needs and interests of female researchers a gender action plan is foreseen.Over the four years funding period an average funding rate of only 2,000,000 ? per year is requested. To prepare for time after community support, TARGET will submit itself to an annually decreasing budget so that there will be need for the network to achieve its own financing.",Top Amplifier Research Groups in a European Team,FP6,31 December 2007,31 December 2003,8000000.0 TASMANIA,University College London,photonics,"Communication networks and molecular plasmonics are two scientific disciplines, which at first sight might seem completely unrelated but which are about to meet in the emerging fields of nano-networks and nano-communication. Currently networks on chips are still using electronics, which is limited by dissipation losses and low speed. Optics cannot be used on nanoscale because of the diffraction limit of light. Plasmonics on the other hand offers high speeds and can be confined in nanoscale waveguides. In order for it to be really applicable to nano-networks, active devices such as switches and repeaters have to be created. A promising path to explore in the search for active devices on the nanoscale is the coupling between molecules and plasmons. The project aims to study the coupling between archetypal optically active molecules, the metal phthalocyanines and surface plasmon polaritons. It will also look at the scattering of plasmons from molecules and their subsequent propagation in order to identify possible anisotropy, which would allow for the application of the molecules as a plasmonic switch. A preliminary theoretical study has given promising results in this direction. Thus, even though theoretical, the project could have important practical results. The third objective is even more audacious: it aims at looking for interactions between the molecular spin state and the surface plasmons. Such an interaction would constitute huge breakthrough and allow control of the plasmons on quantum level as well as single-shot readout of the molecular spin. Furthermore the project will allow the researcher to undertake an inter-disciplinary experience and establish her as an independent scientist. In this way she can fully utilize her multi-disciplinary, multi-sector background to contribute to the synergy of ICT and nano-technology, thereby increasing European competitiveness in the emerging fields of nano-networks and nano-communication.",TheoreticAl Study of MoleculAr Spin PlAsmonics for Nanoscale CommunIcAtions,FP7,28 February 2013,01 March 2011,172403.0 TASNANO,National Polytechnic Institute of Lorraine * Institut National Polytechnique de Lorraine,information and communications technology,"Scanning proximity probes (SPP) are uniquely powerful tools for molecular analyses, and sensing: they are capable of addressing and manipulating surfaces at the atomic level and therein are keys to unlocking the full potential of Nanotechnology. Current SPP nanotools are limited to several probes with optical readout and slow processing rates, mostly at the research level. This presently constitutes a severe limitation in the manufacturing viability of this technology. Through the realisation of 2-dimensional massively parallel probe arrays with integrated piezoresistive readout and their individual and/or modular nanofunctionalisation, an avalanche of new tools and processes for a wide range of applications including sensing, electronics and the life-sciences industries would be viable. We expect breakthroughs in a new generation of tools for molecular level characterization and manipulation methods along the following directions: - A generic Nanotool provided by a Massively Parallel Nano-Electro Mechanical System (MP NEMS) chip incorporating array of intelligent proximal probes with integrated actuator and piezoresistive readout, fully addressable, for high-speed data analysis or bottom-up product synthesis. - The modular generic NEMS-chip will be 'Nanofunctionalised' to generate a family of application specific NEMS-chip packages (AS NEMS) for integration into a range of new intelligent, cantilever based Nanotools. - Prototypes of experimental Nanotools based on the functionalised AS NEMS chips developed in TASNANO will be produced and demonstrated in selected applications and the results used to support the development of new Nanotechnology processes and products. It is the aim of TASNANO that the new modulariy functionalised nanotools with MP ASNEMS 'chips inside' should empower nanotechnologists and drive the development of nano-scale science, leading to new nanotechnology processes and their industrial exploitation.",Tools and Technologies for the Analysis and Synthesis of Nanostructures,FP6,30 June 2008,01 January 2005,2150000.0 TAT MACHINE,Rijksuniversiteit Groningen * University of Groningen,health,"Bacterial protein secretion is a fundamental biological process of the utmost relevance to human health. On one hand, this process can be exploited successfully to the benefit of human health through the biotechnological production of biopharmaceuticals. On the other hand, secreted bacterial toxins and virulence factors represent a major threat to human health. The Twin-arginine translocation (Tat) machinery represents a recently discovered, but widely conserved system for bacterial protein secretion. This multi-subunit nanomachine can transport fully folded proteins and thus has a huge potential for biopharmaceutical production in bacterial species that are already used for this purpose, including Bacillus, Escherichia coli and Streptomyces. It has furthermore been demonstrated that critical virulence factors are secreted via Tat in important pathogens, such as Pseudomonas aeruginosa and E. coli O157. The Tat machine programme aims at the multidisciplinary functional genomic characterisation of the Tat nanomachine for both biotechnological and biomedical purposes. We will: (A) eliminate the current bottlenecks in the Tat nanomachine that limit biopharmaceutical production in Bacillus, E. coli and Streptomyces; and (B) characterise the structure and function of Tat nanomachines from a few selected Gram-positive and Gram-negative bacteria, including major pathogens. To reach these goals, the full potential of bioinformatics, comparative and structural genomics, and proteomics will be exploited. The Tat machine partnership has a proven track record in the application of these cutting-edge technologies and includes Europe's leading groups in the field of Tat machinery analysis.",Functional genomic characterization of the bacterial Tat complex as a nanomachine for biopharmaceutical production and a target for novel anti-infectives,FP6,31 October 2008,01 November 2004,2000000.0 "TBID,CL AND CYT C",Technical University Dresden * Technische Universität Dresden,information and communications technology,"One of the main control points of programmed cell death affects the release of cytochrome c and other proapoptotic factors from the mitochondria. The detailed mechanism by which cytochrome c is completely and rapidly liberated to the cytosol is not yet well understood, but it appears to involve two steps: i) redistribution of the cytochrome c stored in the mitochondrial cristae and ii) selective permeabilization of the outer mitochondrial membrane. tBid, a proapoptotic protein of the Bcl-2 family, has been recently related to the lipidic reorganization that takes place at the mitochondria during apoptosis. Addition of tBid to mitochondria induces quick morphological changes which interconnect cristae and make cytochrome c available at the outer mitochondrial membrane. This activity seems to depend on interactions with the mitochondrial lipid cardiolipin, which, being an anchor to cytochrome c at the inner mitochondrial membrane, redistributes during apoptosis, and mediates the selective targeting of tBid to the outer mitochondrial membrane. Recently, it has been observed by epifluorescence microscopy that tBid induces the appearance of novel cardiolipin microdomains in monolayers. Single molecule optical techniques have been applied to study raft-associated proteins and lipid mobility in vivo and in vitro. Fluorescence correlation spectroscopy uses the temporal dimension and constitutes a powerful tool to study lipid and protein dynamics in domain-forming membranes. It is the objective of this project to characterize the formation of cardiolipin enriched domains induced by the presence of tBid in connection with the process of mitochondrial cytochrome c redistribution that occurs during apoptosis, by means of fluorescence correlation spectroscopy and microscopy in membrane model systems and mitochondria.",Mitochondrial membrane reorganisation induced by tBid during apoptosis: cardiolipin and cytochrome c redistribution analysed by single molecule spectroscopy and microscopy,FP6,31 December 2008,01 January 2007,149722.0 TCAMMD,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The constant improvement of microelectronic devices is based on their miniaturization from the micrometer to the nanometre scale. This continuous scaling down calls for new materials and new device concepts. At the nano-scale, the thermophysical properties of the materials have a fundamental impact on the electronic behaviour of the device. Despite this, a non destructive experimental technique capable of determining the thermophysical properties of the key materials in a real microelectronic device is still lacking. The goal of this project is to develop a technique, based on the infrared radiation measurement, capable of addressing the device nano-scale. To achieve this objective the experimental technique must be combined with the heat transfer modelling in the device under investigation. The project will focus on specific microelectronic devices such as ultra-scaled metal-oxide-semiconductor field-effect transistors (MOSFETs) as well as novel non-volatile memories (NVM) based on phase-change materials (PCM). In the latter case the determination of the thermal properties of the active material (calchogenides) and of the heater (TiN) is very important for the device functional characterization. An additional objective of the project is also to use the developed technique to address the thermophysical properties of thin films, such as oxides with high and low dielectric constant, which today are considered as substitutes of silicon oxide both in the front as well as in the back end of near future CMOS technology. This study will be carried out in collaboration with an important European industrial partner, STMicroelectronics. This work will therefore contribute to a relevant technological evolution in the field of microelectronics with consequent economical repercussions.",Thermal Characterization of Advanced Material in Ultra-scaled Microelectronic Devices,FP6,31 August 2006,01 September 2005,103240.0 TCPBRCBDP,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"One promising strategy for the production of biofuels from cellulosic, hemicellulosic and lipid materials is to use polyols as a platform. Recent advances have led to direct and (potentially) large scale production of polyols such as ethylene glycol, glycerol and sorbitol. Nevertheless, the downstream production of valuable fuels from polyols is comparatively lacking. In this project we intend to bridge this gap by developing a new strategy that could directly convert polyols into valuable acetals. To achieve this, a one-pot multi-step process through tandem catalysis is envisaged. Acetals will be produced through classical acetalisation reactions between polyols and aldehydes, with the latter being produced in situ from syngas by a tandem Fischer-Tropsch (F-T) reaction and hydroformylation reaction. An efficient, dual functional hybrid catalyst based on a nanoparticle core to which a homogeneous catalyst is tethered that is capable of both F-T and hydroformylation reaction will be designed and synthesized, which to our knowledge represents the first approach of tandem F-T/hydroformylation catalyst. In-situ spectroscopic techniques, such as IR and NMR, will also be applied to study mechanistic aspects of the reactions. The approaches described herein are of high novelty with respect to both biomass conversion and heterogeneous/homogenous catalysis potentially leading to be the more efficient use of renewable resources.",Tandem catalysis for the production of biofuel related chemicals from biomass derived polyols,FP7,30 April 2012,01 May 2010,181970.0 TDRFSP,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"One of the most important developments in the communication microelectronics in the last decade was the invention and popularization of “Digital RF”. It transforms the radio frequency (RF) analog functionality of a wireless transceiver into digitally-intensive implementations that operate in time-domain. They are best realized in mainstream nanometer-scale CMOS technologies and easily integrated with digital processors. As a result, RF transceivers based on this new approach now enjoy significant benefits. Consequently, the RF transceivers based on this architecture are now the majority of the 1.5 billion mobile handsets produced annually.",Time-Domain RF and Analog Signal Processing,FP7,08 July 2019,09 January 2012,0.0 TECHNOTUBES,University of Cambridge,information and communications technology,"Carbon nanotubes are materials with a set of unique electrical, mechanical, surface and thermal properties. Yet their adoption in mainstream applications has been limited by mass production and device integration. This project develops the first 300mm wafer-scale equipment for production of carbon nanotubes on surfaces. The project will cover the design, engineering, process control, quality assurance, qualification and process development. It will develop applications in cathodes for time resolved X-ray sources for X-ray tomography, cathodes for high power microwave amplifiers, interconnects for VLSI, thermal management surfaces, low stiction surfaces for micro-fluidic channels and filters, wafer scale fabrication of spin valve devices, and sensor surfaces for integrated sensors on CMOS.",Technology for Wafer-scale Carbon Nanotube Applications,FP7,04 June 2014,05 January 2009,5300000.0 TEM-PLANT,National Research Council * Consiglio Nazionale delle Ricerche (CNR),manufacturing,"TEM-PLANT project focuses on the development and application of breakthrough processes to transform plant-derived hierarchical structures into templates for the exploitation of innovative biomedical devices with smart anisotropic performances and advanced biomechanical characteristics, designed for bone and ligament substitution. Natural bio-structures usually have properties superior to those of analogous synthetically manufactured materials with similar phase compositions. The remarkable biomechanical properties of bone and ligament tissues depend on their hierarchic structure which is an organized assembly of structural units at increasing size levels. In fact, these structures are highly organized from the molecular to nano-, micro- and macro-scales, always in a hierarchical manner, with intricate but extremely functional architectures able to constantly adapt to ever changing mechanical needs.The TEM-PLANT project primary addresses the nano-biotechnologies area and will push the current boundaries of the state-of-the-art in production of hierarchical structured biomaterials. By combining biology, chemistry, materials science, nanotechnology and production technologies, new and complex plant transformation processes will be investigated to copy smart hierarchical structures existing in nature and to develop breakthrough biomaterials that could open the door to a whole new generation of biomedical applications for which no effective solution exists to date. Starting from suitably selected vegetal raw material, ceramization processes based on pyrolysis will be applied to produce carbon templates, which will be either infiltrated by silicon to produce inert SiC ceramic structures or exchanged by electrophoresis deposition to produce bioresobable ceramics. For ligament yielding two processes will be developed: pH-controlled and electrophoresis- controlled fibration to generate fibrous collagenous cords with high tensile strength and wear-resistance.",New Bio-ceramisation processes applied to vegetable hierarchical structures,FP6,31 March 2011,01 October 2006,2600000.0 TEMADEP,University of Leuven * Katholieke Universiteit Leuven,information and communications technology,"Template-based deposition for the synthesis of nanowires and nanotubes is extensively reported for metals, alloys, and semiconductors. Properties and possible applications of such nanostructured materials were investigated to some extent; inclusive by parties cooperating in this project, but there is still a large need for an ample scientific study in order to support a future implementation in the European industry. This multidisciplinary project comprises research activities in electrochemistry, materials science, surface technology, film/nanostructures characterization, tribology, and corrosion science, and includes the electrodeposition, structural, mechanical, morphological characterization of deposits, corrosion and wear protection. The low cost electrodeposition of the following alloys is of interest in this project, namely alloys containing iron group metals, tungsten-containing iron group alloys, Mo-Ni alloys. Taking into account the large potential of such procedures for the electroforming of nanostructures and MEMS, the objective of this project is to intensify research activities to select and to improve existing procedures and plating bath formulations to deposit nanocrystalline films with a roughness equal or less than the roughness of the substrates. The films/coatings must posses pre-specified structural, mechanical, tribological, and chemical properties that are necessary to apply them in electroformed nanostructures such as nanowires/nanotubes, and in MEMS. Mapping of tribological, thermal, magnetic and corrosion behavior of films/coatings and nanowires/nanotubes, and MEMS will perform. The market potential of obtained results will analyze.",TEMPLATE-ASSISTED DEPOSITION OF FUNCTIONAL MATERIALS AND DEVICES,FP7,12 July 2015,01 January 2011,104400.0 TEMPSYNTHFIX,Technische Universiteit Eindhoven * Eindhoven University of Technology,photonics,"A unique construction process for supramolecular assemblies in the 10-100 nm length scale that act as (opto)electronic and/or solar energy processing devices is proposed. For the fabrication of these nanoelectronic components, oligonucleotides (DNA) or oligopeptides (PNA) will be used as a template for the construction of perfect-defined p-conjugated oligomer assemblies. Different p-conjugated molecules, such as oligo(p-phenylene vinylene) and perylene bisimides, that contain a specific hydrogen-bonding unit will be synthesized. This supramolecular recognition motif will be complementary to one of the bases of the single-stranded DNA/PNA template. In such a way, semi-conducting stacks will be constructed that are monodisperse and well-defined, that is, have a specific number of building blocks in a precise position. The self-assembled stacks will be covalently fixed at this stage by photopolymerization reaction of suitable pendant groups. The fixation process will increase the stability and processability of the materials for their transfer to solid substrates or their connection to electrodes. These structures are ideal systems to investigate fundamental issues within the nanometer scale like light harvesting, exciton diffusion length, energy and electron transfer processes and the conversion of light into chemical or electrical energy. The project, having a very interdisciplinary and technological character, is perfectly suited for the young applicant. On one hand, his vast postgraduate experience in the organic chemistry and properties of molecular materials make him a perfect candidate to accomplish the different tasks successfully. On the other hand, the clear orientation of the project towards the supramolecular organization of organic functional compounds will enrich and complement his scientific skills and outlook for a brilliant independent professional future.",Templated synthesis and fixation of self-assembled p-conjugated oligomers using DNA and PNA,FP6,31 October 2007,01 November 2005,149276.0 TEOX,Queen Mary University of London,energy,"Thermoelectric (TE) materials are of considerable interest because they can convert waste heat to useful electrical energy and will contribute to reducing the global energy crisis. They have been successfully applied to power generation from exhaust heat of automobiles, and have many other potential commercial applications. To realize such applications, TE materials are required that have not only good TE properties, but are also low cost, environmentally friendly, thermally stable and oxidation resistant. Oxide ceramics meet these criteria. Among the large family of oxides, the layered perovskite-related oxides with low lattice thermal conductivity due to the layered structure and possibly high power factor due to the transition metal-oxygen octahedral networks are promising high performance TE materials. So in this proposal AE-Nb-O (AE=alkali earth metals Ca, Sr or Ba) based layered perovskite-related oxides are considered, and their TE properties will be evaluated and improved by using multidisciplinary approaches, including theoretical screening for high TE performance materials, spark plasma sintering of the highly textured ceramics picked out by screening, doping to optimize the TE properties, modeling of the nanosheets containing ceramic composites to utilize the low dimensional effects, and spark plasma sintering of the composites with optimal parameters for high TE performance. The idea of the nanosheets containing ceramic composites is particularly novel and has not been previously reported, and the whole research involves several state of the art concepts and techniques in the TE field and materials science. The main objective is to develop TE oxide with zT>1 above 800K, which corresponds to a heat-to-electricity conversion efficiency greater than 10%, while at the same time improving the understanding of the underpinning physics. This work could make a highly original and significant contribution to the TE field and materials science.",New Thermoelectric Oxides for Energy Harvesting,FP7,19 September 2016,20 September 2014,231283.0 TERA,TeraVil UAB,energy,"TERA proposes to perform a joint industry academia research programme capitalising on the knowledge and expertise of the partners through exchanges of researchers and transfers knowledge between research centres in Photonics and Nanoscience at the University of Dundee and SME UAB TERAVIL with expertise in different aspects of laser physics, material science and THz radiation. The aims are to overcome scientific and technical barrier to the realisation and adoption of low-cost technologies for the fabrication of compact room-temperature terahertz sources emitting few tens of ïW powers at 0.3–1.5 THz and beyond for Biophotonics and Safety and Security applications. The THz radiation will be obtained by difference frequency generation from CW or pulsed dual wavelength laser produced by combination of laser diodes with novel volume Bragg reflectors . Together the project partners will evaluate several variants for the THz generation procedures. Photoconductive mixers based on traditional and new materials and photovoltaic travelling-wave mixers will be assessed, targeting increased conversion efficiency",Novel Compact Terahertz source based on Dual Wavelength Lasers and Photomixers,FP7,29 February 2016,01 March 2012,1104208.0 TERABIT CHIPS,Technische Universiteit Eindhoven * Eindhoven University of Technology,manufacturing,"Dramatic progress has recently been made in the development and convergence of communication and computing technologies. Increasing numbers of networked consumer goods and remote electronic services requiring instant bandwidth are adding a huge burden to existing electronic infrastructure. While optical technologies are being deployed in increasingly diverse information systems, making a major impact on the use of ethernet networks, switching and routing functions remain in the electronic domain. This results in major bottlenecks, and while photonic integrated circuits have the promise to process ultrahigh speed data, stringent cost, power and space constraints have so far prevented deployment.TERABIT CHIPS provides a route map to high capacity active integrated photonic circuits using cutting edge fabrication solutions, advanced photonic design concepts, and sub-system architectures by exploiting parallel processing concepts. While the size of photonic circuits may be constrained by the wavelength of light, interaction lengths for electrooptic phenomena and limits to lithography, exploiting parallelism through wavelength multiplexing within the photonic circuit is identified as a highly efficient way to unleash a potential multiterabit capacity without prohibitive space, management or power overheads. This work proposes the multiwavelength components to realise such circuits.This proposal targets fast nanosecond reconfigurable routers for data traffic as the demonstration technology for prototyping high functionality high capacity integrated circuits. The designs will be deployed to ensure near digital operation with minimal signal impairment. Prototypes will be fabricated and demonstrated for broadband loss-free transmission, and nanosecond scale network reconfiguration times. The technology will exploit cutting edge fabrication, being compatible with off the shelf hardware, linking in to existing physical layer standards.",Photonic integrated circuits for ultrahigh speed reconfigurable data networking,FP6,31 March 2009,01 February 2006,557197.01 TERACAN,University of Exeter,information and communications technology,"Creating reliable portable devices working in the terahertz (THz) range of electromagnetic spectrum is one of the most formidable tasks of contemporary applied physics, with nanostructures being at the heart of the most promising proposals. This project aims at elaborating a general approach to the description of electromagnetic processes in various carbon-based nanostructures, investigating their electromagnetic properties, and developing a physical basis for utilizing these properties in novel THz nanodevices. The complementary characters of the two key factors inherent in solid-state nanostructures, the spatial confinement of charge carriers and intrinsic nanoscale inhomogeneity of electromagnetic fields, drastically modify their electronic and optical properties. Whereas the first factor lies in the focus of current research activity of the nanoscience community, the role of the second factor was underestimated before. The proposed research is focused to fill this knowledge gap for carbon-based nanostructures. As a whole, the project contributes to the novel interdisciplinary research field, the nanoelectromagnetics, which represents a synthesis of macroscopic electrodynamics of inhomogeneous media and microscopic theory of electronic properties of nanostructures. We will study carbon nanotubes (CNTs) and graphene representing latest trends in carbon-based nanotechnology. As shown in our proposal, unique physical properties of these nanostructures provide the basis for novel THz applications. To achieve the ambitious goals of this project, the consortium involves scientists from both electromagnetic and nanostructure communities. Intensive transfer of knowledge between them is essential for success of the project.",Terahertz applications of carbon-based nanostructures,FP7,12 July 2014,01 January 2009,86400.0 TERAEYE,C. Engineering Srl,transport,"The objective of TERAEYE is to develop an innovative range of inspecting passive systems, based on Terahertz (THz) wave detection, to detect harmful materials for homeland security. Main applications will be related to airports security systems, surveillance of crowded areas such as railway and metro stations; detection of chemical and biological harmful substances and hazards in post and goods. TERAEYE aims at a technological breakthrough in the THz sector through the development of a new fabrication process for cheap nano-fabricated 2-D matrix array of detectors that will strongly reduce the production cost of the THz sensors. These technological developments would constitute the basis for the longterm breakthrough introduction of totally new detection and scanning systems to be applied for security applications, thus opening up new market perspectives for a new set of products and services based on the passive THz detection, and thereby supporting a radical transformation in the security sector. TERAEYE has been conceived as an IP, being a large-scale industry-driven research initiative aimed at creating new applicable knowledge and integrating breakthrough technological solutions, having a strong inter-disciplinary character, in a full range of products and services. The project addresses vertical integration of the full value-chain of innovation stakeholders from the basic nanoscience-based development of the sensor through the industrial technology development, to the final product design and development. TERAEYE addresses horizontal integration as it fosters scientific multidisciplinarity (nanoscience, electronics, cryogenics, spectral imaging) and promises to trigger innovation in a variety of secondary industrial sectors.",A low cost and fully passive Terahertz inspection system based on nano-technology for security application,FP6,30 June 2011,01 January 2007,5999983.0 TERAFILM,Free University of Berlin * Freie Universität Berlin,photonics,"We propose a time-resolved Terahertz (THz) investigation of ultrafast dynamics in semimetals and carbon nanotubes. The THz spectroscopy is a direct and powerful tool to explore the optical properties in the far- and mid-infrared. When combined with a visible pump beam, it can measure the transient dielectric response of an excited system with time resolution better than 100 fs. This unique capability has been already exploited to observe the building up of electron-hole plasma in semiconductors and the excitonic transitions in heterostructures. On the track of these promising results, we aim to characterize hot electrons dynamics in graphite. Our goal is to extend the investigation to the carbon nanotubes and observe the influences of the reduced dimensionality on the fast conductivity transients. The project chaises also the optimization of innovative gas sensors that would detect toxic and polluting species. It is well established that the conductivity of metal-phtalocyanine films changes dramatically under NOx exposure. Together with the electronic transport, also the thickness and the optical properties of the film modify considerably. We propose a THz investigation of these solid-gas systems in order to characterize the plasma frequency, the quasiparticle scattering rate and the molecular vibration during the absorption of the sensing gas.","Time-resolved Terahertz investigation of semimetals, carbon-nanotubes and gas-sensing films.",FP6,31 October 2007,01 November 2005,149155.0 TERAGAN,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"T-rays, often called terahertz radiation or submillimeter waves, are loosely defined as the wavelengths from 30 µm to 1, 000 µm, or the frequencies from 10 THz to 300 GHz. This non-ionizing radiation appears as a harmless alternative to x-rays in medical, biological and security screening. Current solutions in terms of coherent sources of T-rays either require cryogenic temperatures or are relatively bulky equipments based on optically-pumped materials. The solid-state recourse consisting of GaAs-based quantum cascade lasers presents an intrinsic limitation in operation temperature: The low energy of the longitudinal-optical (LO) phonon in arsenide compounds hinders laser emission beyond 180 K at 4 THz, and forces operation below the liquid nitrogen temperature (< 70 K) for frequencies below 1 THz. Overcoming this limitation requires a technology revolution through introduction of a new material system. This project aims at exploring a novel semiconductor technology for high-performance photonic devices operating in the T-ray spectral region. The advanced materials that we will investigate consist of nitride-based [GaN/Al(Ga, In)N] superlattices and nanowires, where we can profit from unique properties of III-nitride semiconductors, namely the large LO-phonon energy and the strong electron-phonon interaction. Our target is to adapt the quantum cascade design and fabrication technology to these new materials, characterized by intense internal polarization fields. Our project aims at pushing intersubband transitions in this material family to unprecendently long wavelengths, in other to cover the whole T-ray spectral gap with coherent solid-state sources operating at room temperature and above.",GaN Quantum Devices for T-Ray Sources,FP7,31 December 2016,01 January 2012,1627236.0 TERAMIX,Chalmers University of Technology * Chalmers Tekniska Högskola,photonics,"Terahertz heterodyne receivers are valuable tools for molecular gas spectroscopy both for space (radioastronomy, planetary science) and terrestrial applications. They provide both high resolution spectral data, as well as broad bandwidth line survey data. Due to the progress in device physics, such receivers can now reach several THz. At such high radio frequencies, neither electronic nor photonic approaches for THz detectors work, but rather a combination of both is required. Superconducting devices have proven to provide sensitivity levels close to the quantum limit, hf/k. Superconducting Hot- Electron Bolometers (HEB) based on ultrathin NbN and NbTiN films are currently the only devices which are used as mixers for frequencies above 1.2THz (SIS mixer limit). However, their speed (i.e. the instantaneous bandwidth) is limited by the finite electron energy relaxation rate, of 40-100 ps. It corresponds to the bandwidth of maximum 4-5GHz. Such applications in radio astronomy as extragalactic spectroscopy, molecular line survey require this bandwidth to be doubled to say at least. In this project we will investigate response rate in ultra thin MgB2 superconducting films. Preliminary investigation measured the electron-phonon interaction time as short as 1ps. Our recent data, point out on the response rate being limited by the phonon dynamic in the thick films. We will develop technology for ultrathin MgB2 film deposition, and processing THz nanobolometers. The response rate will be investigated with regards to the film parameters. In particularly, the phonon diffusion in superconducting nanobolometers will be studied in order to enhance the instantaneous bandwidth of MgB2 mixers. We estimate that the bandwidth of the novel THz detectors will be at least doubled compared to the existing once, providing completely new functionalities for THz radio astronomical receivers.",Study of Novel Low Noise Superconducting Mixers for Terahertz Radio Astronomy,FP7,30 September 2017,01 October 2012,1497775.0 TERNANOMED,University of South Paris * Université Paris-Sud,health,"Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challenging project will be performed under Patrick Couvreur s leadership who has settled up a worldwide recognized multidisciplinary research team, unique in the nanomedicine world.",TERPENOYLATION: AN ORIGINAL CONCEPT FOR THE DISCOVERY OF NEW NANOMEDICINES,FP7,31 May 2015,01 June 2010,2198799.0 TETTRA,IBM Research GmbH,information and communications technology,"Tunnel transistors are currently considered promising candidates for future low-power high performance information processing applications. The proposed project TETTRA – Towards Enhanced III-V Tunnel TRAnsistors – is dedicated to the fabrication and characterization of III-V nanowire tunnel field-effect transistors (FETs). III-V semiconductor heterostructure nanowires, grown on Si substrates by means of the selective-area-epitaxy method, serve as basis for the tunnel FETs. The project concentrates on n-type tunnel FETs and furthermore focuses on one specific realization with regard to the choice of materials involved; i.e. n-type tunnel FETs consisting of a p-type GaSb source, an InxGa1-xAs channel, and an n-type InAs drain. This sequence of III-V materials is grown in the form of vertical heterostructure nanowires directly on silicon substrates, with InAs being in contact with the substrate and GaSb forming the nanowire tip. The heterostructure nanowires are then processes into vertical, gate-all-around tunnel FETs. The fabrication of the nanowire heterostructure and the processing of the III-V nanowire tunnel represent one of two main objectives of the project. Investigations on the growth of GaSb on InxGa1-xAs, on the p-doping of GaSb, and on metal contacts to GaSb are preceding the tunnel FET fabrication. The second objective of the project comprises the electrical characterization of the nanowire-oxide interface properties and the electrical characterization of III-V tunnel FETs. For characterizing the nanowire-oxide interface properties two independent techniques will be employed: capacitance-voltage measurements and the charge-pumping technique. Both deliver the interface trap level density, Dit, and both have been demonstrated to be applicable to single nanowire capacitors and FETs, respectively. Characterization is complemented by detailed investigations of the electrical properties of the III-V nanowire tunnel FETs.",Towards Enhanced III-V Tunnel Transistors,FP7,03 July 2016,04 January 2012,184709.4 THE FUSION MACHINE,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Cells release neurotransmitters, hormones and other compounds stored in secretory vesicles by a process called exocytosis. In this process, the molecules are released upon stimulation by a nanomachine forming a fusion pore that connects the vesicular lumen to the extracellular space. Similar fusion events are also essential for intracellular transport mechanisms and virus-induced fusion. Here I propose a multidisciplinary approach using highly innovative techniques to determine the nanomechanical mechanism of fusion pore formation. The proposal is based on the hypothesis that the vesicle fusion nanomachine is formed by the mechanical interactions of the SNARE proteins synaptobrevin, syntaxin, and SNAP-25 and that the fusion pore is opened by intra-membrane movement of the transmembrane domains. I will combine fluorescence resonance energy transfer microscopy with detection of individual fusion events using microfabricated electrochemical detector arrays to demonstrate that fusion pore formation is produced directly by a conformational change in the SNARE complex. I will estimate the energies that are needed to pull the synaptobrevin C terminus into the hydrophobic membrane core and the forces that are generated by the SNARE complex for wild type and a set of specific mutations using molecular dynamics simulations. I will determine how these energies and forces relate to inhibition and facilitation of experimentally observed fusion, performing patch clamp capacitance measurements of vesicle fusion in chromaffin cells expressing wild type and mutated SNARE proteins. Based on these results I will develop a detailed picture of the molecular steps, the energies, and the forces exerted by the molecular nanomachine of fusion pore formation and will ultimately generate a molecular movie of this fundamental biological process. Understanding cellular and viral fusion events will likely lead to novel treatments from spasms and neurodegeneration to cancer and infectious disease",The nanomechanical mechanism of exocytotic fusion pore formation,FP7,31 March 2018,01 April 2013,2165200.0 THECOSINT,University College London,information and communications technology,"The recently emerged discipline of quantum information promises to have a profound impact on the information technologies that so deeply permeate our society. The search for an actual quantum information processor involves different physical systems, thus motivating an exciting interdisciplinary research ground. In this framework the present project will involve contributions from various branches of quantum science, with emphasis to cutting-edge quantum technologies in condensed matter and quantum optical systems. The project -besides enhancing the competence diversification of the candidate- is properly tailored for his scientific trajectory which, starting from investigations on quantum information and quantum optics, aims at progressively acquire expertise in the field of many-body systems. This, in turn, is expected to strongly support the candidate in attaining a leading independent position. Specifically, the main objective of the project is to investigate theoretically novel approaches to quantum simulators (QS) and quantum computation (QC) properly tailored for new quantum technologies. The two major quantum information paradigms will be considered: discrete and continuous variables. The first goal is to individuate the benefits offered by novel technologies such as circuitQED, microcavities, and nano-elecromechanical oscillators. Then these technologies will be exploited to find novel proposals for QS of strongly interacting many-body systems (both spin and bosonic systems). The presence of thermal noise will be addressed by using new ideas emerged in the field of quantum thermodynamics. Finally, the last goal is the search for new continuous variable schemes for QC. We will focus on measurement based QC, a new computation paradigm which exploits the synergies between quantum information and many-body systems. To face the drawbacks that historically affect continuous variable QC the benefits offered by the above mentioned technologies will be harnessed.",Theory of Quantum Computation and Many-Body Simulation with Novel Quantum Technologies,FP7,01 June 2015,01 July 2013,165540.8 THEOFUN,University of Ulm * Universität Ulm,health,"The aim of this project is to understand the mechanisms behind the functionalisation of metal surfaces with organic and biological complexes under realistic electrochemical conditions. Focusing on low-index surfaces of gold and platinum, which are also the electrodes in corresponding experiments, we will use a series of theoretical methods applicable for different time- and lengthsscales to investigate the geometry and electronic properties of different complexes attached to these electrodes as function of the surrounding (e.g. electrolyte) and the environmental conditions: temperature, pressure/concentrations, and electrode potential. As complexes we will consider small organic molecules such as 4-mercaptopyridine, 4-ATP, or alkane-chains of variable length, as well as biological complexes, i.e. DNA-sequences. Within the first step we will establish a deeper understanding of how these complexes interact with the metal electrodes and how adlayer structures can be manipulated by applying specific temperature, pressure, or potential-conditions. Since the intermolecular interactions are rather weak, the presence of the external electrode potential could lead to drastic changes of the interfacial morphology. In this respect, particular attention will be spend to the highly-reversible folding and unfolding of DNA-sequences, which has recently had been realized experimentally. Based on thus functionalized electrode surfaces, we will investigate their potential as templates for growing nanoparticles of desired size and shape, which would allow for bridging the gap between well-defined single crystal surfaces and nanoparticles. It is now a matter of establishing the predictive capacity for these methods, an expansive process that itself will open new doors of research.",Theoretical studies on the functionalisation of metal surfaces with organic and biological complexes under electrochemical conditions,FP7,31 March 2016,01 April 2011,1409400.0 THERAGLIO,IRCCS - Istituto Nazionale Neurologico Carlo Besta,health,"Microbubbles (MBs) are used as contrast agent in ultrasound (US) imaging for a variety of tumours while little has been done for glioblastomas, a rare cancer. Intraoperative Contrast-Enhanced US-imaging (CEUS) using lipidic MBs hold promises in increasing extent of resection of such tumors. Furthermore, MBs gained recently interest as a delivery system for drugs. We will develop a new generation of multimodal MBs, acting simultaneously as contrast agent for Magnetic Resonance Imaging (MRI), CEUS and intra-operative fluorescence for multimodal real-time image-guided resection of glioblastomas. We plan to transform MBs by replacing air with perfluorcarbon gas and/or attaching super-paramagnetic-iron-oxide nanoparticles for MRI visualization. We will also engineer MBs with RGD-motif to adhere selectively to pathological endothelial integrins and with near-infrared fluorophores for simultaneous US deep tissue imaging and direct microscopic tumour visualization to maximize resection. A software will be developed for integration of preoperative MRI, intraoperative US and microscopic imaging. We will focus on lipidic and polymeric MBs. Lipidic MBs are approved for clinical use; therefore, once modified, more easily translatable into clinical applications to reach a feasibility study on patients. In addition, we will improve multifunctional, polymer-based MBs. Multifunctional-stabilized-polymer-MBs are more stable and more versatile to be complexed with different molecules or nanoparticles as compared to lipidic Mbs and will be designed as a platform for delivering standard and/or experimental chemotherapeutic drugs to the tumour, acting as an innovative way for local targeting and delivering any kind of agent to a specific target, in a safe and controlled fashion. This would be a big step forward in the field of personalized medicine, moving standard MG image-guided treatment towards more effective, safer, molecular-based tailored interventions to specific patients.",Microbubble driven multimodal imaging and theranostics for gliomas,FP7,30 September 2018,01 October 2013,5998890.0 THERALENS,Aston University,health,"design and development of biocompatible and biomimetic polymers, in the form of hydrogels as soft tissue analogues for biomedical applications, especially those related to the cornea such as contact lenses. Synthesis of nanoparticles to encapsulate therapeutically active molecules and development of a hydrogel layer encapsulating the loaded nanoparticles for contact lenses technology improvement. Development of methods to detect living tissue-biomaterial interactions. The project will encompass synthesis, fabrication, physico-chemical characterization and in vitro testing.",biomimetic therapeutic hydrogel layers for interaction with corneal tissues,FP7,30 April 2015,01 May 2013,299558.0 THERAVAC,German Cancer Research Center * Deutschen Krebsforschungszentrum (DKFZ),health,"At least 20% of human malignancies are caused by consequences of persistent infections. High-risk human papillomavirus (HPV) types cause over 500.000 cancer cases per year, rendering HPV the #2 human carcinogen after tobacco. Infection-related tumors are attractive targets for cancer vaccination, as they provide the opportunity to target antigens that are immunological non-self. Vaccination can be prophylactic, inducing immune responses preventing infection in the first place, or therapeutic, stimulating the immune system into eradicating established disease. Prophylactic immunization against HPV has become the paradigm for cancer immunoprevention. Unfortunately, current HPV vaccines have no therapeutic effect on existing infections. Studies on spontaneously regressing HPV-induced lesions show that cell-mediated immune responses are crucial in clearing established HPV infection. Cytotoxic T cells (CTL) kill infected cells after recognizing viral epitopes presented on HLA molecules on the cell surface. There are hundreds of different HLA types, and a given epitope is only applicable for the fraction of patients with the relevant HLA molecule. This project will define a set of T cell epitopes that elicit CTL-mediated HPV protection in the entire population, by including epitopes for all HLA supertypes. The applicant has established a methodology of determining which viral epitopes are presented on target cells during her past mobility period in the US. HPV-transformed cells of various HLA backgrounds are analyzed by nanospray mass spectrometry. Identified peptides are tested for immunogenicity and the ability to induce CTL. From these tests, a minimal set of functional epitopes providing >95% population protection coverage is selected for vaccine formulation. The technology is currently transferred to the DKFZ. If this epitope-specific, yet widely applicable therapeutic vaccination approach is successful, it can be used as a platform technology in other malignancies.",Development of a therapeutic HPV vaccine via target epitope identification by mass spectrometry,FP7,30 November 2015,01 December 2011,100000.0 THERMALCOND,AIMPLAS - Plastics Technology Centre * Asociación de Investigación de Materiales Plásticos y Conexas,energy,"The main goal of the project is to develop a new family of low cost polyolefin based components (sheets, pipes and fittings) to be used in the manufacture of flat-plate solar thermal collectors. These components are expected to be a viable alternative to current collector's metallic components. However, due the current limitations of thermoplastics materials (low thermal conductivity and low resistant coatings) two main developments will be claimed in this project: • Polyolefin nanocomposites by using different nanoparticles with high thermal conductive properties as additives. • A novel and specific surface treatment based on SAM technology to provide an energy absorber flexible coating (based on metallic oxides, e.g. TiO2 or ZnO) to the different components. These developments will allow novel low cost and low weight components design's with enhanced thermal conductivity and high solar energy absorption to develop high efficiency thermal collector designs. The use of plastics components instead of metallic ones offers additional advantages: folding and easy assembling structures design, low energy consumption in motorized thermal collectors (follow sun light), corrosion resistance, low friction coefficient (less pump energy consumption), prevent theft or vandalism (due the low cost of components in comparison with copper). The solar thermal collector parts to be substituted by the new thermal conductive materials and flexible absorber coatings will be the extruded pipes and injected fittings of the collector heat absorption circuit and extruded sheets which will be used as absorber plate. In this context, the polymeric materials appear as a real alternative to develop new low cost procedures in which a wide variety of component's designs could be obtained to optimize the thermal energy obtained per thermal collector surface. Due to their properties, plastics permit to produce any type of part with a free design at very competitive cost.",Polymeric composite materials with enhanced thermal conductivity properties for heat exchangers applications,FP7,30 November 2012,01 December 2010,1056160.0 THERMIQ,Queen's University Belfast,energy,"A quantum technology going beyond microscopic borders will be confronted with aspects of thermodynamics that are yet to be understood. This is important, both from a fundamental perspective and with a view to development of quantum devices. Here we propose a comprehensive research programme — which we dub TherMiQ — aimed at developing a general framework that brings together thermodynamics and the physics of mesoscopic open quantum systems. The programme builds on an active interplay between theoretical and experimental work. Specifically, we pursue three scientific lines: 1. To provide unambiguous definitions of thermodynamical quantities that are genuinely quantum. 2. To construct mesoscopic thermal engines able of realising heat, mass and entropy transport at the quantum level. 3. To test the foundations of quantum mechanics through thermodynamical concepts. TherMiQ will provide the theoretical backbone for a new generation of experiments in mesoscopic systems. In particular, we will focus on a) Entropic transformations and heat exchange processes in quantum-optomechanical devices and their hybridized versions comprising the interface with simple atomic systems and levitating nanoparticles; b) The construction of thermodynamical cycles and super efficient machines using ultracold atoms placed in controllable optical potentials; c) The design and implementation of schemes for thermometry of strongly correlated quantum systems through novel diagnostic tools. Our programme will build on an information-theoretical approach and aims to provide a clear route towards the development of a self-consistent, experimentally viable apparatus for exploring and eventually exploiting quantum thermodynamics.",Thermodynamics of Mesoscopic Quantum Systems,FP7,31 December 2016,01 January 2014,2110564.0 THERMO-SPINTRONIC,University of Zaragoza * Universidad de Zaragoza,energy,"In view of the global energy and environmental demand, the necessity to use the energy sources more efficiently becomes relevant. Since most of energy is still being lost into the environment as waste heat, significant amount of renewable energy remains unused. In this context, thermoelectric materials, which can generate electricity from waste heat, could play an important role in a sustainable energy solution optimizing its consumption. However, the application of thermoelectric generation based classical Seebeck effect is limited to specific cases due to efficiency problems. The control and re-use of heat are therefore important topics in thermoelectricity as well as for the development of spin-based electronics, called spintronics. A recent discovery of spin-Seebeck effect (SSE), reported as a measurement of a redistribution of spins along the sample or 'spin voltage' induced by a temperature gradient, generated strong interest in the research community. The existence of this novel effect was recently demonstrated in metallic ferromagnets, diluted magnetic semiconductors and even in oxide insulators. This work aims to obtain a more efficient heat-to-electricity conversion by the combination of these two properties: the classical Seebeck effect and Spin-Seebeck effect being pioneer in applying this concept. To study the interplay between these two effects, suitable binary oxides and perovskite system will be fabricated in insulator/metal hybrid systems (oxides/ferromagnets) and in high-quality superlattices and/or nanoparticles. The insulator will provide the low thermal conductivity which enables to suppress the energy loss due to heat conduction and the SSE could augment the thermoelectric generation efficiency. For this project, modern synthesis methods and state-of-the-art characterization will be employed. The results will highlight the engineering of heat transport in spintronic devices and facilitate the functional use of heat.",High Performance Energy Conversion by the interplay between Thermoelectricity and Spin Seebeck Effect,FP7,31 August 2016,01 September 2012,100000.0 THERMOCS,AIT Austrian Institute of Technology GmbH,transport,"Within the Clean Sky JTI, the use of a nanocomposite material for primary structures of a Green Regional Aircraft is going to be thoroughly studied and analysed. The nano-filler modified matrix have a great potential to exhibit high performance in terms of thermal, mechanical and electrical properties. The modified resins should able to be used in the prepreg route for composite fabrication, which means that the uncured resin must exhibits proper rheological properties and dispersion in liquid phase compatible with the impregnation of dry fiber fabrics. The objective of AIT is to manufacture nanomodified resins to fulfil the requirements of the Clean Sky roadmap. In a first step, nanoparticles will be selected among 1D (needle shape like carbon nanotubes or nanofibres), 2D (plate shape like nanoclays) and 3D (ball shape like Al2O3, ZrO2, or Boehmite) geometries. Then AIT will benefit of its experience in nanotechnology to set-up the dispersion methods, to produce batches of modified resin (12 different types are planed), to set up the curing parameter, to produce samples and finally, to characterize them. The proposed test campaign will investigate the chemical, physical, morphological, rheological, thermal, mechanical and electrical properties. The dissemination and exploitation of the result will be assure by the management Team in close communication and collaboration with the ITD leaders and other CS-RTD partners.",Thermosetting resin for Clean Sky,FP7,09 June 2012,01 January 2010,74250.0 THERMOMAG,European Space Agency * Agence Spatiale Européenne,energy,"The core concept of the ThermoMag project revolves around developing and delivering new energy-harvesting thermoelectric materials and proof-of-concept modules, based on nanostructured bulk Mg2Si solid solutions. This class of TE material would have the following attractive characteristics: (i) ZT value >1.5 for both n-type and p-type doped material, (ii) operational in the temperature range 300-550ºC, (iii) very low density of 2 g/cm3, especially suitable for transportation applications, (iv) high melting point of >1000ºC, and good thermal stability up to 600ºC, (v) good oxidation and corrosion resistance and mechanical strength, (vi) isotropic thermoelectric properties, (vii) non-toxicity of elements, (viii) widely-available pure materials with very large EU supply chains and (ix) low raw material cost <15 Euros/kg, combined with low manufacturing costs. A number of methods will be looked at to achieve 3D bulk nanocrystalline Mg2Si including low-cost combustion synthesis, mechanical alloying and high-temperature solid-state synthesis in inert crucibles. Various ball milling approaches will be used to produce doped Mg2Si nanoparticle constituents that can then be compressed via rapid spark plasma sintering or hot pressing in vacuum. 3D nanocomposite material will also be produced with the addition or in-situ production of inert nanoparticles, as well as thin films using multilayer approaches. Doping using various elements will be predicted by ab-initio density-functional theory modelling. These methods will lead to the safe production of nanostructured n- and p-type legs for further thermoelectric and materials testing. In order to prove the concept works, demonstrator modules will be assembled that integrate the new energy-harvesting nanostructured material. Such modules have widespread applications in automotive, aerospace and manufacturing sectors, where waste heat can be usefully recovered, with clear environmental benefits.",Nanostructured energy-harvesting thermoelectrics based on Mg2Si,FP7,31 October 2014,01 May 2011,3986980.0 THERMONANO,Polytechnic University of Turin * Politecnico di Torino,health,"Low temperature heat recovery is often limiting the energy efficiency of industrial processes. Low temperature differences imply large exchange surfaces which are unfeasible from the economic (expensive metal are needed to withstand the presence of condensates) and technical (too large volumes for the specific application contexts) viewpoints. The present project aims at developing nanofilled-polymer-based heat exchangers enabling: i) effective heat conductivity due to the percolation network of carbon or metal fillers; ii) cost reduction compared to metal materials (stainless steel, Cu-alloys,…); iii) design flexibility for an intensive volume exploitation; iv) superior corrosion resistance; v) promotion of the highly effective drop condensation with hydrophobic polymers. Three main application areas are devised: 1. Intercoolers increasing the efficiency of large diesel engines, where heat conductive plastics can provide a cheaper alternative to Cu-alloys when seawater is used as the cooling media (e.g. large naval engines or power plants close to sea side). 2. Heat recovery systems from combustion flue gases acting below 300°C, where commercial metal-based systems loose cost-effectiveness. 3. Application in the chemical and process industries where harsh chemicals or corrosive environments have to be faced. The project is divided into three main work lines: i) development of compounds in which a range of polymers (nylon, PET,…) and fillers (carbon fibres, carbon nanotubes, metal coated nanoparticles, …) will be considered; ii) tailoring of plastic forming techniques (injection moulding, pressing, extrusion); iii) manufacturing & testing of up to two proof-of-concept heat exchangers. The partnership includes two Universities (POLITO-I, TUBAF-D), two research centres (CEA-F, PISAS-SK), three SMEs (Astrarefrigeranti-I, Nanocyl-B, Starom-RO) and two large companies (Simona-D, SGL Carbon-D) selected for their specific expertise to undertake the above challenges.",LOW-TEMPERATURE HEAT EXCHANGERS BASED ON THERMALLY-CONDUCTING POLYMER NANOCOMPOSITES,FP7,30 June 2012,01 January 2009,2638387.0 THERMOSOMENANOREACT,University of Basel * Universität Basel,health,"Polymer nanoparticles have found applications in high performance materials and in medical applications. An attractive route to these particles is the use of templates. However, templating methods have the disadvantage that one templating entity is needed for every object that is formed. The ideal template for polymerizations would therefore be a nanoreactor that regenerates itself once the nanoparticle is formed. Nature provides us with a protein assembly that, when further modified, may fulfill this requirement. The thermosome from Thermoplasma acidophilum is a protein complex which encloses two central cavities with a void volume of 130 nm3. Each cavity is accessible via several small pores and one large pore. The large pore is gated by a build-in lid, whose opening and closing can be controlled by ATP. I propose to use the thermosome as a nanoreactor for Atom Transfer Radical Polymerization (ATRP). To this end, an appropriate catalyst will be covalently linked into the cavity of the protein complex. In the thermosome's closed conformation, monomers, crosslinkers and initiators can enter the cavity through the small pores, and a polymer particle will form inside of the protein. The cavity of the thermosome acts as template in order to generate nanoparticles of defined size and shape. By opening the lid, the particles will then be released into the surrounding media and the nanoreactor regenerated for further reaction cycles. The objective is to run the process in a continuous way, so that the production of the nanoparticles becomes catalytic. To this end, the formation of the particles will be synchronized with the opening-and-closing cycle of the thermosome. Furthermore, the effect of the confined reaction space provided by the cavity will be exploited to achieve an enhanced control over the ATRP reaction in order to synthesize polymers of narrow molecular weight distribution with significantly less copper-based catalyst than normally needed for aqueous ATRP.",Nanoreactors for controlled radical polymerizations based on the thermosome from Thermoplasma acidophilum: Templating synthesis of polymer nanoparticles and in-situ regeneration of the template,FP7,28 February 2011,01 March 2009,184203.0 THINK,Aix-Marseille Université * Aix-Marseille University,health,"In this project, we propose to explore a new area in biological research aiming at dissecting emerging of properties of the innate immune responses. Our system model is the Natural Killer (NK) cell. Specifically, we will investigate the mechanisms by which these players of innate immunity achieve tolerance to self and participate to immune responses. Multidisciplinary approaches will be combined to achieve groundbreaking results at nanoscopic and macroscopic scales on the following issues: - How NK cells are educated to self-tolerance? - How NK cells distinguish their targets from normal cells? - How NK cells participate to immunological memory? THINK (THe Immune function of Natural Killer cells) is a challenging project supported by an array of preliminary data obtained by our team of investigators in various fields of expertise: - innate immunity and NK cells in human and mouse models - random insertional mutagenesis in the mouse - genome-wide epigenetic, transcriptomic and RNAi analysis and - state-of-the-art optical imaging techniques from intravital biphoton microscopy to the quantification of proteins in nano-sized areas of the cell. THINK is thus a multidisciplinary project that bridges disciplines: immunology, biophysics, genetics and epigenetics. In a scientific perspective, we think that this project will open new technological and scholar horizons, in reassessing the actual concepts on the links between innate immunity, tissue homeostasis and stress response. In a clinical and translational perspective, we also think that this project will help to design innovative NK cell-based therapies and immunomonitoring protocols.",The Immune function of NK cells,FP7,30 June 2016,01 July 2011,2500000.0 THREADMILL,University College London,energy,"THREADMILL aims at enabling cross-disciplinary training and research at the interface between Supramolecular Chemistry, Electrical Engineering, Physics, and Nanoscience. The overall goal is the generation of new knowledge underpinning the exploitation of supramolecular wires (namely conjugated polyrotaxanes) in the fabrication and investigation of prototypical systems, both at the level of single-molecule devices, and of large-area polymer applications (LEDs, PVDs, ultrafast photonic switches). The training and research objectives of THREADMILL are: 1 Supramolecular synthesis. Engineering of van der Waals, ionic, and p-p stacking interactions, leading to prototypes of multifunctional nanowires. Special emphasis on polyelectrolytic, conjugated polyrotaxanes. Synthetic and processing breakthroughs sought by combining Anderson synthetic chemistry expertise with that on ionic liquids of Mecerreyes. 2 Nanofabrication of electrodes nanostructures (metals and conductive plastics) 3 Self-organisation. self-assembly of hybrid metallic-supramolecular architectures. Scanning probes, XPS, and TOF-SIMS. 4 Applications I: single-molecule devices. Fabrication of organic nano-optoelectronic devices incorporating prototypes of supramolecular wires operating at surfaces. 5 Transport studies. Measurement of charge transport and mobility in organic semiconducting wires bonded between homogeneous/heterogeneous electrodes. A theory component will be provided by collaboration with an independent, ongoing project at UCL. Details and a letter of support will be provided if invited to submit a full proposal. 6 Ultrafast spectroscopy. evaluation of the TMWs potential for ultrafast switches. General photophysical characterisation of ultrafast processes. 7 Applications II: large area devices. optoelectronic devices incorporating large ensembles of the supramolecular wires. Target applications: LEDs and photovoltaic diodes. 8 Dissemination and strategic development.",THREADed Molecular wIres as supramoLecularly engineered muLtifunctional Materials,FP6,30 September 2010,01 October 2006,2706476.99 TICAL,European Organization for Nuclear Research (CERN),health,"This 4-year project proposes a breakthrough in particle detectors by developing a highly granular calorimeter with high-resolution timing information, thus providing precise information of the space-time development of electromagnetic and hadronic showers. The objective of this project is to develop a completely new imaging calorimeter that uses light encoding methods, and thus simultaneously records: - the total energy deposited in the calorimeter cells with a time tag in the 10 picosecond (ps) range; - the high-precision spatial distribution of the energy deposition in the calorimetric volume both for low energy (photo-electric and Compton) and high energy (shower components); - the time structure of the signals corresponding to the different components of the shower. The key point in this novel approach is to introduce light production, collection and detection techniques that are now accessible due to spectacular technological advancements in this field, in which the PI is directly involved. Examples are: - new crystal production technologies (micro-pulling-down (μ-PD,) ceramics, nano-crystals); - photonic crystals, plasmonic resonances and nano-optics; - single-photon-counting silicon photomultipliers, both digital(d-SiPM) and analogue (a-SiPM). The use of precise time information in the tens of picosecond range in calorimetric techniques will have a large impact on different applications in many domains: - High Energy Physic (HEP), in particular at new high energy and high collision rate colliders; - Medical imaging in Time of Flight Positron Emission Tomography (TOF-PET); - Spectrometry of low energy γ- quanta; - Homeland security: crystals of higher sensitivity always be in demand; - Space applications.",TICAL: 4D total absorptionTime Imaging CALorimeter,FP7,31 January 2018,01 February 2014,2258000.0 TIFFE,Research Center Fiat * Centro Recherche Fiat (CRF) SCPA,energy,"The project is devoted to the development of an innovative Integrated Vehicle Thermal System based on the integration of vehicle thermal systems to improve the on board thermal management and the energy efficiency. The major project contents are: - Dual loop air conditioning: one loop to transfer the cooling power and one loop to reject the heat - Two-levels temperature heat rejection system: one temperature to reject the high temperature heat (e,g. engine waste heat) and one temperature to cool locally the vehicle auxiliary systems - Innovative heat exchangers: new generation of compact fluid-to fluid heat exchangers and application of innovative technologies for fluid-to-air heat rejection - Use of innovative coolants (e.g. Nanofluids): to improve the heat rejection and redesign the heat exchangers TIFFE benefits can be summarised in a Cost Reduction (due to resize of the systems and their integration) and Fuel Economy increase of 15% on real use thanks to the: - improvement of the aerodynamics due the new front end design - increase of auxiliary systems efficiency thanks to the local cooling - engine overall efficiency thanks to a fine control of heat exchange, local cooling (turbocharge, fuel, ...) and improvement of the engine intake - the reduction of engine re-starts on Hybrid or Stop&Start vehicle due to cabin thermal comfort: the dual loop air conditioning with a designed thermal inertia guarantees thermal comfort when the thermal engine is off - compact Refrigeration Unit compliant with Low GWP refrigerants -R744 or flammables (e.g. R152a, R1234yf) Two prototypes will be realised and validated: • a gasoline passenger car with Stop & Start function • a diesel Light Commercial Vehicle with hybrid power train Both will undergo to a complete series of road and climatic chamber tests and a long range road test - e.g. from Catania (I) to Cape North (N) - to verify the reliability and effectiveness of the system and to promote its exploitation.",Thermal Systems Integration for Fuel Economy,FP7,31 March 2013,01 June 2009,2042075.0 TIME,Aalborg University * Aalborg Universitet,health,"Amputation of a limb is a surgical intervention used as a last resort to remove irreparably damaged, diseased, or congenitally malformed limbs where retention of the limb is a threat to the well-being of the individual. The procedure traumatically alters the body image, but often leaves sensations that refer to the missing body part, the phantom limb. In 50-80% of cases, these sensations are painful and currently, there are no effective treatment modalities. Given sufficient control over a large number of nerve fibers, a neural interface may be able to artificially evoke sensations of touch, or counteract the phantom limb pain. The application of Micro/nano technologies with functional electrical micro stimulation can not only pave the road towards a treatment, but also also provide amputees a means to sense virtual environments directly. The ultimate aim of this project is to develop this novel Human Machine Interface (HMI). A novel microfabricated neural interface, the Thin-film Intrafascicular Multichannel Electrode array, and implantable multichannel stimulator system will form the key core technological developments in the project. The work is structured in 10 work packages in three phases. The technological development phase will model, design, manufacture and characterize the multi-channel electrode (TIME) and design, manufacture and test an implantable, multi-channel stimulator. In vivo characterization phase will evaluate the TIME electrodes for biocompatibility, stability and chronic safety in animals and develop a psychophysical test platform for system integration. Finally, pre-clinical evaluation will test the system in short-term implants in amputee subjects. The work will provide direct contribution to the next-generation smart systems in the ICT-2007.3.6 Nano/Micro priority, strengthen Europe's leading position in advanced electronic systems/biomedical applications, and improve the quality of life for amputees with phantom limb pain","Transverse, Intrafascicular Multichannel Electrode system for induction of sensation and treatment of phantom limb pain in amputees",FP7,30 April 2013,01 May 2008,3650000.0 TISA TD,University of Stuttgart * Universität Stuttgart,health,"Although hardly visible in daily life, today precision laser micro-machining is employed in a broad and rapidly growing range of medical and industrial applications significantly affecting everybody's life. Short and ultrashort pulsed lasers enable producing structures with sub-micron accuracy, for example diesel injection nozzles which help reducing air pollution significantly when compared to nozzles made by conventional fabrication techniques. So far, most of the powerful industrial ultrafast laser sources are operating in the picosecond range, which is sufficient for precision micro-machining of metals. On the other hand, to achieve optimum precision in micro-machining of transparent materials like glass and ceramics, pulse durations in the order of 100 femtoseconds are required. Therefore, the main objective of the project is to demonstrate the feasibility of industrial high-average power ultrafast Ti:sapphire (Ti:Sa) lasers and their excellent qualification for demanding high-productivity precision laser mate-rial processing applications. To achieve the targeted high output powers, the thin-disk (TD) geometry shall be employed, which already enabled the efficient generation of up to 740 W of cw fundamental mode power from one Yb:YAG crystal. Symmetrical double-sided cooling with two transparent diamond heat spreaders shall be used to optimize the cooling of the thin Ti:Sa crystal. Within the project, two ultrafast Ti:Sa TD laser systems, one with chirped pulse amplification (CPA) to obtain high-energy pulses and the other without CPA for high repetition rates, both with a maximum average output power of at least 200 W at a pulse duration of well below 100 fs shall be demonstrated. The CPA system, comprising a multipass TD amplifier, shall achieve a pulse energy of 10 mJ at 20 kHz repetition rate. The multipass amplifier will be pumped by two nanosecond pulsed frequency-doubled solid-state lasers developed within the project which are operating at 532 nm with an average output power of 300 W each. The high-repetition rate system shall be a high-power TD oscillator with a pulse energy of 20 µJ at about 10 MHz. A commercial cw Yb:YAG TD laser with intracavity frequency doubling emitting about 500 W at 515 nm shall be used as pump source. To demonstrate the excellent qualification of the ultrafast oscillator for fast, ultra-precise micromachining of transparent materials, high-speed cutting of glass, e.g. Gorilla® glass, which is widely used for mobile phones and tablets, will be investigated as high-volume reference application. With the CPA system, which is especially well suited for ultra-precise drilling, the ultra-high aspect ratio percussion and single-shot drilling of transparent substrates shall be investigated. Other potential applications, including -but not limited to -large area precision volume structuring for microfluidics or integrated optics, enabled by the new powerful femtosecond sources will also be studied in the project.",Ultrafast High-Average Power Ti:Sapphire Thin-Disk Oscillators and Amplifiers,FP7,30 November 2016,01 December 2013,3130000.0 TITOXPATH,Ludwig Maximilian University of Munich * Ludwig-Maximilians-Universität München,health,"The rise in use of nanotechnology has significantly increased risks of human exposure and interaction of nanoparticles with the immune system, potentially jeopardizing host responses to infection. There is a critical need to define the functional immunological consequences of chronic nanoparticle exposure. Lack of this knowledge could potentially confound efforts to prevent, diagnose, and treat infectious diseases in people whose immune system responses may have been affected by exposure to nanomaterials. The objective of the proposed studies is to define genetic and innate immune responses of zebrafish neutrophils to exposure to nano-TiO2 as well as functional consequences in host responses to disease causing pathogens. The hypothesis is that exposure to nano-TiO2 will 1) cause measurable changes in leukocyte transcriptome response and neutrophil function; and 2) increase morbidity and mortality in disease challenged zebrafish. The rationale for the proposed research is that insights into nano-TiO2 dependent changes in host immune response to pathogens will allow better assessment of risks associated with chronic exposures to metallic oxide nanoparticles. The public health relevance of the proposed research is reflected in the fact that nano products are rapidly accumulating in the environment and their potential for causing adverse health effects is growing proportionately, but the contribution of environmentally-relevant nanoparticle doses to modulation of infectious disease pathology remains unclear. The proposed research is significant because it is expected to increase our mechanistic understanding of the biological activity of nano-metallic oxides and assess their potential for chronic toxicity, and to allow us to evaluate the safety of metallic oxide nanoparticles. Integration of Dr Palic to EU scientific community network will be greatly enhanced with this opportunity to retain and expand collaborations with knowledge transfer from the U.S. to Germany.",Role of Nano-Titanium Dioxide Immunotoxicity in Infectious Disease paThology,FP7,31 August 2017,01 September 2013,100000.0 TNP-HGNS,Gazi University * Gazi Üniversitesi,health,"The functionally controllable molecules that are activated upon irradiation, have received a significant attention as nano-scale delivery tools in biomedical applications. Among these, photolabile caged therapeutic molecules are chemically blocked species which can be liberated in their active form by exposure to ultraviolet (UV) radiation. By precise tuning of UV source, the use of these photosensitive probes becomes a unique tool to treat a selected biological target spatially and temporally. This technique has been successfully employed in a variety of biological studies; however, it is mostly limited to in vitro applications. The restriction is mainly due to the destructive effects of UV light which has shallow tissue penetration with strong absorption. Quite the contrary, near-infrared (NIR) radiation is known to have deep tissue penetration with minimum absorption. This outstanding property of NIR, with the aid of strong NIR absorbers, can be utilized to trigger a mechanism in cells for therapeutic and diagnostic (theragnostic) purposes. Among other metal nanoparticles that have been extensively studied for such purposes, gold nanoparticles, such as hollow gold nanostructures (HGNs), emerge as ideal tools for these applications since they possess optical tunability, easy functionalization, inertness, non-toxic behavior, accumulation in tissues, and intense absorption of NIR light. During the NIR absorption process, the absorbed energy by HGNs will be transferred into thermal energy that consequently heats the surroundings. This NIR mediated heating process can be employed for thermal cleavage of chemical bonds within the molecules, so called 'thermolabile caged compounds'. This project proposes a novel design and synthesis of NIR driven thermolabile caged molecules as a nano-scale delivery tool, and their self-assembly on HGNs for targeted therapy and optical imaging applications.",Self-Assembled Thermo-NanoProbes on Hollow Gold Nanoparticles For Theragnostic Applications,FP7,31 May 2013,01 June 2010,75000.0 TOMECS,Technical University of Denmark * Danmarks Tekniske Universitet,information and communications technology,"Molecular electronics is expected to become a key technology in the 21st century with extensive current research. Owing to its future importance, molecular electronics is included in one of the seven FP6 priority areas, viz Nanotechnologies and Nanoscience. Our project will contribute to both the theoretical understanding of functional molecular electronic devices, and to their development and application. Target systems are inorganic transition metal complexes attached to suitable conducting leads. These systems exhibit molecular conductivity features that mimick electronic components such as diodes or transistors. However, most work published so far has been at low temperatures in vacuum or air. We intend to expand the area to ambient temperatures using in situ STM and scanning tunnelling spectroscopy (STS) in electrochemical environments. The in situ STM electrode configuration consisting of a reference, a counter and a working electrode, resembles closely a molecular transistor with source, drain and gate contacts. Together with cooperation partners who will synthesize identified classes of inorganic complexes, we will develop molecular designs that are most suitable for our experimental requirements. Electrochemical experiments using ultrapure, atomically planar single-crystal metal electrodes will help to test the novel designs, e. g. concerning stability, prior to in situ STM experiments. In parallel, condensed matter charge transfer theory and detailed electronic structure calculations of the molecular tunneling junction will correlate molecular conductivity features to its properties. A profound understanding of this correlation is a pre-requisite to tailoring molecular tunneling properties, a key issue in present and forthcoming molecular electronics research.",Single-Molecule Resonant Tunnelling in Small Transition Metal Complexes - Towards Molecular Electronics,FP6,30 September 2006,01 November 2004,178433.6 TOPBIO,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),health,"Two-photon absorption is a photophysical process with diverse applications in medicine (photodynamic therapy), neurophysiology, cell biology (microscopy, photo-activated drugs) and biomedical engineering (fabrication of micro-needle arrays and tissue scaffolds). Many of these applications will only have a major impact when better dyes become available with stronger two-photon absorption, as well as improved secondary properties (photostability, biocompatibility, etc). Advances in optical engineering will also be critical. Two-photon absorption is an important newly emerging supra-discipline at the intersection of Biology, Chemistry, Physics and Engineering. This network will be the first initiative of its kind in this area. TOPBIO will train young researchers in many different aspects of the field, by coupling together research groups with internationally recognized expertise in synthesis, molecular design, theory, photophysics, photobiology, cell biology, engineering, nanotechnology, microscopy and laser physics. We aim not only to train ESR and ER in an interdisciplinary manner but also (by developing new generations of functional dyes and applying them in real biomedical applications) to improve the quality of life in Europe and to strengthen the EU economy. TOPBIO will provide an excellent mechanism for promoting interdisciplinary training, by exchanging PhD students on secondments between collaborating laboratories, through regular progress meetings, workshops and tutorial schools. TOPBIO brings together leading experts from universities and private sector organizations across Europe. It has an exceptional ratio of private to academic partners (1:2). The perfect match of complementary expertise, multidisciplinarity, high involvement of companies and focus on the real needs of society will enable us to deliver high quality training in skills which are perfectly matched to the needs of future employers, thus producing a workforce which will be in high demand.",Two Photon Absorbers for Biomedical Applications,FP7,30 November 2014,01 December 2010,3232751.0 TOPCRYST,National Centre of Scientific Research Demokritos * Ethniko Kentro Erevnas Fysikon Epistimon Dimokritos (EKEFE),health,"The elucidation of 3-dimensional structures of proteins and other biological macromolecules and complexes is essential for rational drug design, targeting and delivery, biocatalysis, the design of environmentally friendly agrochemicals, the development of biosensors and other nanobiotechnological applications. The most powerful tool for structural analysis is X-ray crystallography, which crucially depends on growth of high diffraction quality crystals. Crystallisation is the least controllable and usually rate-limiting step of the process that goes from cloning a gene to using the structural information for predicting and designing function. TOPCRYST, an academia-industry project, will use Dual Polarimetric Interferometry, pioneered by Farfield Scientific Ltd., to probe crystallisation at its earliest, most crucial stages. This will allow to predict the outcome of crystallisation trials when they are still at their earliest stages and thus to rationally design such experiments in order to lead them to the desired result, i.e. well-diffracting crystals. Transfer of knowledge between academia and industry will tackle the problem of detecting crystal nucleation phenomena at the very earliest stages of crystallisation and holds a number of promises that will be investigated in its course: (i) to guide the choice of pH and buffer, temperature, precipitating agent, additive(s) etc, starting from a limited number of preliminary experiments, thus obviating the need for extensive screening; (ii) to allow to unequivocally distinguish crystalline from amorphous material, something which is not always easy even for an experienced crystalliser, with obvious possibilities of extension to high-throughput environments; (iii) to allow optimisation of conditions under real-time control; (iv) to provide an experimental underpinning to the theoretical understanding of nucleation phenomena (v) to develop novel instrumentation for crystallisation of macromolecules.",Novel tools for crystallisation of macromolecules,FP7,29 February 2012,01 March 2008,514764.0 TOPOPLAN,IBM Research GmbH,health,"The controlled synthesis of nanoparticles in the form of spheres, rods and wires has led to a variety of applications. A much wider spectrum of applications e.g. in integrated devices would be available if a precise placement and alignment relative to neighbouring particles or other functional structures on the substrate is achieved. A potential solution to this challenge is to use top-down methods to guide the placement and orientation of nanoparticles. Ideally, a precise orientation and placement is achieved for a wide range of particle shapes, a so far unresolved challenge. Here we propose to generate a tunable electrostatic potential minimum by exploiting double-layer potentials between two confining surfaces in liquid. The shape of the potential is determined by the local three-dimensional topography of the confining surfaces. This topography can be precisely tailored using the patterning technology that has been developed in our research group. The potential shape can be adapted to fit to a wide range of particle shapes. The trapping energies exceed the thermal energies governing Brownian motion and trap and orient particles reliably. After trapping, the particles are transferred in a subsequent step onto the substrate by external manipulation. The separation of the trapping and placement steps has several unique advantages over existing strategies. High aspect ratio structures or fragile pre-assembled structures like nanoparticles linked by DNA strands can be pre-aligned in the trapping field and placed in the desired geometry. For applications like the placement of quantum dots into high fidelity cavities, the trapped particles can be examined optically and repelled if the spectral properties do not match. In particular the precise positioning of nanowires is promising to build up complex circuits for (opto-)electronic applications. Additionally, the trapping and placement processes proceed in parallel and high throughput values can be achieved.",Topographically guided placement of asymmetric nano-objects,FP7,30 September 2017,01 October 2012,1496525.0 TOPOSPIN,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"In the last thirty years great progress in solid state physics was mainly driven by the discovery of novel highly unique material systems. Materials such as high tc superconductors, carbon nanotubes, semiconductor nanowires and graphene reshaped our understanding of modern solid state physics. In particular, each of these materials opened a new chapter in the multidisciplinary fields of nanotechnology and nanoscience.",Scanning tunneling spectroscopy of topological interfaces for future spintronics,FP7,02 April 2017,03 January 2012,0.0 TOPPCOAT,Juelich Research Centre * Forschungszentrum Jülich,energy,"The aim of this project is to make significant improvements to thermal barrier coating (TBC) systems used for gas turbine applications by introducing a number of key innovations.TBC's consist of an oxidation resistant (Co,Ni)CrAlY bond coat and a insulating yttria-stabilized zirconia top coat. The top coat is deposited by air plasma-spraying (APS) or by electron-beam physical vapour deposition (EB-PVD). The use of the much more expensive EB-PVD process has been due largely to the columnar structure of the coatings resulting in improved strain tolerance and improved reliability. The in-service life of these coatings is now around 8000 hours. Conventional APS coatings are deposited onto a random, rough grit blasted surface. A new method which produces a controlled, 3D surface morphology will be used to both improve bonding and, crucially, enable control of the TBC microstructure. In particular providing a much higher segmentation crack density. Most failures in TBC systems occur at the interface between the topcoat and the bond coat. Interfacial adhesion will be improved by the introduction of nano-crystalline inter-layers. Finally, new processes for the deposition of the TBC will be studied. These include; thin film - LPPS, plasma enhanced CVD, nano-phase suspension PS and high speed PVD. Unlike EB-PVD, they will enable advanced TBC materials such as alumina based to be used. The project aims to provide significant improvements to TBC systems using a number of innovative steps. It is expected that this work will not only extend the life of conventional TBC's but also provide the breakthrough necessary to achieve 'next generation' TBC systems.Maintaining a lead in gas turbine technology is strategically important for Europe. The participation of all the key European companies in this sector not only underscores the importance of this project but also ensures that the results will have the widest possible impact and benefit.","TOwards design and Processing of advanced, comPetitive thermal barrier COATing systems",FP6,31 January 2010,01 February 2006,2125950.0 TOSCA,University of Leeds,health,"Over the last 10 years, research in the terahertz (THz) frequency region of the electromagnetic spectrum has grown dramatically. The most significant development has been the demonstration of the first THz frequency quantum cascade laser (QCL) in 2002 by my EC FP-V consortium, WANTED. These advances have been accompanied by an equally important industrial applications-pull, with exploitation envisaged in the pharmaceutical and security sectors, for medical imaging and atmospheric sensing, and for high frequency electronics and communications. Yet, the enormous potential of the THz range has still to be unlocked, principally as there remains a lack of versatile, compact THz systems. My vision here is to address this, creating a step-change in the exploitation of THz technology. I will develop the patterning of periodic and aperiodic grating structures both lithographically, and for the first time, electronically, to engineer the photonic properties of THz QCLs. I will demonstrate the use of surface acoustic waves to modulate QCLs piezoelectrically, creating dynamically tunable sources. A continuous wave system-on-a-chip based on a QCL source, waveguide and integrated solid state detectors will be developed, together with an on-chip continuous-wave THz interferometer, and proven in the study of low-dimensional, nanostructured systems. I will develop a compact fibre-coupled broadband THz system, based on 1.55µm fs-laser excitation of photoconductive antennae. Investigations into the fundamental science underlying THz QCLs will include magnetic field gain measurements of THz QCLs to probe the role of non-Markovian transport in superlattice optoelectronic structures. This programme, comprising the symbiotic development of THz engineering and science, will be unique internationally and will open new opportunities and directions in the study and exploitation of THz frequency electronics and photonics.",Terahertz Optoelectronics - from the Science of Cascades to Applications,FP7,31 March 2015,01 April 2010,2491989.0 TOTALCRYST,Technical University of Denmark * Danmarks Tekniske Universitet,health,"The aim of this project is to develop a method for characterization of the structure and dynamics of polycrystals on length scales from the atomic-level to that of the sample. The method, TotalCryst, determines the atomic arrangement within each grain as well as the 3D position and morphology of the grains. The structure of each grain can be solved and refined with an accuracy presently obtainable only by studies of large single crystals. The method applies to inorganic structures as well as macromolecules and probes grains on all length scales from 100 nm to 1 mm. In this project it will be applied to studies within:Chemistry: TotalCryst will enable the identification and structural quantification of numerous complex or dilute structures which cannot be characterized by present methods. The method may find a widespread use in the pharmaceutical industry. Firstly, it accelerates the process of structure determination, a bottleneck in the process of registration of a new drug. Secondly, it enables characterization of drug content, polymorphism and homogeneity in tablets.Structural biology: Attempting to solve ever-larger structures, crystal quality and radiation sensitivity are major concerns. TotalCryst is a novel strategy for overcoming these issues.Time-resolved studies: TotalCryst offers a number of attractive and unique properties making it highly suitable for time-resolved studies. This includes conventional dynamic studies with time constants of the order of seconds as well as studies in the nano- to femto-second regime based on stroboscopic methods involving a laser pump / X-ray probe scheme. An example is the possibility to, for the first time, study photo-sensitive materials, e.g. photoactive switches for photovoltaic devices and pigments.The consortium comprises a group of crystallographers, X-ray physicists and computer scientists as well as experts in pharmacy, structural biology and time-resolved studies.",Total Crystallography: Structure and dynamics of polycrystals,FP6,31 July 2009,01 February 2006,1425600.0 TOTALPHOTON,Heriot-Watt University,health,"How can we construct a high-resolution camera capable of imaging the time-of-arrival, polarisation and wavelength of each of the maximal 10Gphoton/s emitted from a labelled, biological cell? Such a measurement would capture the complete information available in the optical signal, and significantly enhance our ability to observe the organisation, movement and interactions of cellular components at molecular scales. Advances in single molecule light microscopy are steadily improving our understanding of the processes underlying normal cellular function, and their alteration in disease states. However, these technologies are unable to reach their full potential due to their reliance on pre-existing, suboptimal detectors. A dedicated camera technology is now required to permit simultaneous, multidimensional measurements of large cohorts of molecules at high temporal and spatial (sub-diffraction limit) scales through total imaging of the photon flux. Today's digital cameras capture photons in packets of 10-100 thousand and provide them for external display or recording at fraction of second intervals. In order to process photons individually rather than as packets we must develop a camera operating 10-100 thousand times faster. Each pixel must be capable of capturing single photon parameters without compromising the high resolution and sensitivity achieved by current technology. The 'total photon' camera will be realised in nanoscale CMOS technology, based on recent breakthroughs in ultra-miniature single-photon detectors. We will combine these with novel approaches to pixel circuits, image processing and high-speed readout electronics to provide a fundamental research tool for the emerging area of computational microscopy. We will provide access to the full record of photon emission from live cells, and hence the clearest possible visualization of dynamic cellular processes in a single device capable of wide-field molecular spectroscopy and superresolution imaging.",A Total Photon Camera for Molecular Imaging of Live Cells,FP7,31 January 2019,01 February 2014,2280232.0 TOUCHMORE,Polytechnic University of Turin * Politecnico di Torino,transport,"Recent trends in embedded system architectures brought a rapid shift towards multicore, heterogeneous and reconfigurable platforms. This makes chip design enormously complex and imposes a large effort for the programmers to develop their applications. For this reason, new and more efficient tools for software development are needed to ensure software productivity and time to market of new applications. In particular, the automation of the software design process starting from high level models all-the-way down to a customized and implementation on specific architectures is a key factor to increase programmer productivity.",Automatic Customizable Tool-chain for Heterogeneous Multicore Platform Software Development,FP7,05 July 2016,09 January 2011,0.0 TOXDROP,French Alternative Energies and Atomic Energy Commission * Commissariat à l'Energie Atomique et aux Énergies Alternatives (CEA),health,"Implementing highly parallel cell based assays able to replace animal testing is crucial for a large variety of industries. Some cell-based assays have already been achieved using multi-wells plastic plates where individual cell cultures and their stimulations are realised in wells. Unfortunately these novel technologies did not allow to get the level of discoveries that was expected when phenotyping cells for drug discovery and toxicology. DNA chips experiments have already permit massive analyses of animal and human genomes particularly used for in vitro toxicological studies. More information could be obtained replacing the DNA spots by drops of cell culture allowing to establish the relationship between cell phenotypes and chemical toxicity. The aim of this two year ToxDrop project is to develop a Cell on Chip technology where various phenotypes illustrating cytotoxicity can be characterised through the phenotyping of cells in highly parallel cell based reactions on a single chip. The substrate of the biochip will allow to achieve the necessary precision in the formation of the cellular nanodrops and the high content analyses of cell cultures based on fluorescent, high contrast optical based detection as well as mass spectrometry phenotypic signatures. The project will help three European SMEs to get access to the pioneer technology of the Cell on Chip which could be used in particular for cell based in vitro toxicological studies by the industry. The ToxDrop validation will be planned through discussions with ECVAM and realised through tests in cellular nanodrops by academic laboratories specialised in pharmacological and chemical toxicological studies. In order to reproduce on the Cell on Chip several assays previously tested in animals, toxicity will be carried out in nanodrops containing several types of cells issued from various organs of several species. In particular some problems never solved without the use of animal will be tackled on the ch","Highly parallel cell culture in nanodrops, a new format for high content cell based toxicity screening on Cell on Chips.",FP6,31 December 2006,01 January 2005,1615888.0 TPLDS,Technische Universiteit Delft * Delft University of Technology,information and communications technology,"The recent advances in molecular conduction and nanoscale fabrication of electrodes has led to a newavenue of physics research into conduction through low-dimensional systems. There is currently a basiclack of understanding of the microscopic physical mechanisms that control conduction through suchsystems. Studies of microscopic charge-conduction processes in low-dimensional systems are relevantto hi-tech device technologies that rely both on organic and inorganic semiconductors, as the reductionin commercial device dimensions continues. This is equally true of the magnetic media industry, whichis interested in the manipulation of magnetic moments at the extreme limit of magnet size reduction: asingle magnetic cluster.We propose to study transport through low-dimensional systems at the nanometer length scale. Firstly,we wish to study the quantum aspects of the charge-density wave (CDW) conduction mode in quasi-one-dimensional systems at the length scale approaching the amplitude-amplitude coherence length inthese systems (about lOnm), in charge-density wave conductors NbSes and TaSa. This includestunneling of the CDW quasiparticle excitations across weak links and barriers, and Coulomb Blockademeasurements on CDW dots. Secondly, we will study the magnetic and electrical transport propertiesof molecular magnetic quantum dots. This innovatively combines two major areas of recent research:spintronics and conduction through single organic molecules.Our background and expertise in CDW physics will enable a unique perspective on the understandingof conduction in single molecule devices.",Study of in one-dimensional conduction in nanoscale charge-density wave conductors and single molecule magnets,FP6,,,149843.0 TPN,University of Bath,energy,"Mass transport through nanoscale pores (i.e. pores in the nanometre size range) has been studied for many years in disciplines as diverse as membrane science, soil permeability and cell physiology. However, in all these fields, though, the emphasis has always been placed on the macroscopic outcome, while the effects on fluid behaviour of intermolecular forces or physical and chemical interactions between the liquid and the solid surface have often been neglected. The primary objective of the proposed research is to understand quantitatively the behaviour of liquids flowing in nanoscale pores. In particular, a focus will be placed on the nature of interactions between liquids and the pore structures. This can be achieved by systematically studying the effect of pore size, shape, surface chemistry and structure on fundamental nanoscale transport phenomena including wall slip, liquid velocity, surface tension and contact angle of liquids. In order to achieve this objective, I propose the development of an innovative fluidic chip that combines nanochannel manufacturing with traditional microfabrication techniques. This capitalizes on my previous experience in the field of nanoporous alumina synthesis and liquid flow through carbon nanotubes. A detailed description of the nanofluidic chip design is provided in the proposal along with details about the fundamental fluid physics phenomena that will be investigated Although the proposed research focuses on the fundamental understanding of liquid behaviour at the nanoscale, the development of the proposed nanofluidic device will have applications beyond the scope and duration of the work proposed here: Understanding the interactions occurring between liquids and the pore walls they flow through represents a key to optimizing the performance of many systems such as water filtration and desalination processes, separation of liquids, and energy storage systems such as supercapacitors.",Transport Phenomena at the Nanoscale,FP7,31 August 2012,01 September 2008,100000.0 TRAMS,Polytechnic University of Catalonia * Universitat Politècnica de Catalunya,information and communications technology,"Technology projections indicate that future electronic devices will keep shrinking, being faster and consuming less energy per operation. In the next decade, a single chip will be able to perform trillions of operations per second and provide trillions of bytes per second in off-chip bandwidth. This is the so called Terascale Computing era, where terascale performance will be mainstream, available in personal computer, and being the building block of large data centers with petascale computing capabilities. However, these smaller devices will be much more susceptible to faults and its performance will exhibit a significant degree of variability. As a consequence, to unleash these impressive computing capabilities, a major hurdle in terms of reliability has to be overcome. The TRAMS project is the bridge for reliable, energy efficient and cost effective computing in the era of nanoscale challenges and teraflop opportunities.",TERASCALE RELIABLE ADAPTIVE MEMORY SYSTEMS,FP7,12 July 2014,01 January 2010,0.0 TRANDSSAT,Royal Philips Electronics NV * Koninklijke Philips Electronics NV,information and communications technology,"The research fellows in the TRANDSSAT project look for innovations in the enabling electronics to substantially reduce the power consumption of a portable transceiver to the level where they can have lifetime operation from a single battery, which results in a microwatt transceiver. Two fellows will focus on the design of the RF front end and two others on the AD/DA converters. In the integration phase close collaboration between all fellows aims at the design of the microwatt transceiver with reduced power consumption by an order of magnitude, compared to current state-of-the-art.The power reduction is of utmost importance for the development of and brings several design issues. Innovative system design approaches on silicon are required to solve the issue of disproportional power dissipation while increasing the computing power. Because the CMOS process technology development is mainly focussed on purely digital design, special design techniques are needed to integrate for instance the A/D and D/A conversion functions on the same die as the digital signal processing part. The integration complexity is even growing if also the RF front-end needs to be integrated on the same die. Furthermore, it is becoming increasingly difficult to achieve the required analogue performance with a technology that is not optimally suited for analogue circuit design. Several breakthroughs are needed in the IC design methodology, which mostly relate to the combination and integration of complex digital circuitry and highly sensitive, analogue blocks. The main anticipated breakthroughs are on the circuit and architectural level:- Realization of an integrated microwatt transceiver- Reducing power consumption to levels where the energy supply can be through a single battery without the need for replacing or recharging, or even the use of energy scavengers (i.e. energy is gained from the environment)- Overcoming substrate bounce while integrating RF, analogue and digital circuitry.",Total Realization of Analogue and Digital Systems on Silicon for Ambient Technology,FP6,31 December 2009,01 January 2006,666166.93 TRANS-INT,University of Santiago de Compostela * Universidade de Santiago de Compostela,health,"Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication). The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective.",New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier,FP7,30 April 2017,01 May 2012,8000000.0 TRANSEXMAT,University of Nottingham,photonics,"Simulating the interaction of electromagnetic interaction plays a centrol role in the design of new, exotic materials for use in electronic, photonic, and optical systems. In order to design these systems subject to all technical and economic constraints, broad band information on their behaviour is indispensable. Moreover, modern exotic materials and the devices in which they are used can exhibit nonlinear behaviour. This leaves transient (i.e. time domain) simulation the only viable option. The aim of this project is the development of a design methodology and the corresponding software tools for the exotic electromagnetic materials for use in photonics, transformation optics, biomedical imaging, and nano-technology. This project is innovative because it will enable for the first time (i) the design of nonlinear exotic electromagnetic materials, (ii) the design of devices comprising both regions containing uniform and regions containing non-uniform exotic materials, (iii) the design of exotic materials of size and complexity as encountered in practical situations, and (iv) the deployment during the design process of computing infrastructure that is heterogenous and unreliable, allowing the use of more affordable hardware and leading to true scalability.",Transient Analysis of Exotic Materials for Electromagnetics,FP7,31 July 2016,01 August 2012,100000.0 TRANSFECTDNA,Lund University * Lunds Universitet,health,"Cationic lipids (CL) are the most promising candidates for efficient and safe gene-delivery vectors for gene therapy. Compared with viral capsids, CLs do not induce a response from the immune system. Moreover, while viral capsids have a maximum DNA-carrying capacity of about 40 kbp, CLs, which form self-assemblies with distinct lamellar LαC and inverted hexagonal HIIC, or HIC nanostructures when complexed with DNA, place no limit on the size of the DNA. Despite all these promises, transfection efficiency (TE; a measure of the expression of an exogenous gene that is transferred into cells) remains low, and only a substantial increase in the knowledge of relative interactions between CLs, DNA and cell's components can lead to the design of optimal CL-DNA complexes for gene therapy. Here we propose to design and study novel surface-functionalised PEG-CL-DNA complexes with a RGD and SV 40 peptide sequences. The use of PEG is required to avoid opsin complexation (hence, removal from the organism), while the RGD sequence is expected to induce endocytosis, allowing entrance of the complexes into cells. The SV 40 (a nuclear localisation sequence -NLS) is expected to lead to transport of the smaller sized complexes into the nucleus, permitting the usage of CLs as vectors in slowly or non-dividing cells. To test these hypotheses, transfection studies and confocal microscopy will be carried out in cells, whereas the structures and interactions of the complexes will be characterised with synchrotron x-ray diffraction. The interactions between CLs, DNA and cell components (mainly cytoskeleton filaments and cytoskeletal proteins) will be studied in-vitro with synchrotron x-ray diffraction, confocal microscopy and cryo-transmission electron microscopy. The whole of these studies will permit the rationalisation of the crucial parameters affecting TE, based on the structures of CL-DNA complexes and their interactions with the cytoskeleton.","'SURFACE FUNCTIONALISED' CATIONIC LIPOSOME-DNA COMPLEXES CONTAINING PEPTIDE-LIPIDS WITH POLY(ETHYLENE GLYCOL) SPACERS: STRUCTURE, TRANSFECTION EFFICIENCY AND INTERACTIONS WITH THE CYTOSKELETON",FP7,31 January 2014,01 February 2011,250273.0 TRANSFORMERSURFACES,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),health,"The last decades have been characterized by a great interest on nanotechnology applied to biology and medicine. Nanoparticles play a leading role thanks to their novel properties relative to their bulk material counterparts. Within TransformerSurfaces the training-through-research is targeted at synthesizing silica nanoparticles, coated with a molecular monolayer that can in turn be reversibly functionalized with different ligands following the principles of the Dynamic Combinatorial Chemistry (DCC). The goal is to obtain a new surface suitable for a larger range of possible functionalization. In particular, taking inspiration from the striped gold nanoparticles that have been recently discovered in the group, this project is targeted to functionalize the outermost coating of the silica nanoparticles with higher order patterns, especially stripes. In fact, these 'striped' nanoparticles are capable of penetrating cell membranes without porating (creating transient holes associated with leakage and cytotoxicity) as viruses do. Additionally by combining the biocompatibility of silica with the low toxic effect given by the optimization of the ligands arrangement on the surface, we aim to erase the toxicity of nanoparticles.",Dynamic Libraries for the Synthesis of New Multifunctional Silica Striped Nanoparticles,FP7,30 June 2014,01 July 2012,184709.0 TRANSLOCATION,Jacobs University Bremen gGmbH,health,"Multidrug resistant bacteria are now ubiquitous in both hospitals and the larger community. Drug-resistant pathogens are becoming increasingly pervasive, for example, the resurrection of tuberculosis provides one ominous example highlighting the risk associated with evolved drug resistance. Moreover, many pharmaceutical companies abandoned this field and no truly novel active antibacterial compounds are currently in clinical trials. Obviously we need new antibacterial molecules and maybe, novel strategies to develop antibiotics. The novel aspect here is to use state-in-the art techniques to quantify rate limiting steps of individual components involved antibiotic penetration and to validate them at the cellular level. Such a system biology approach identifies bottlenecks of existing antibiotics and might suggest novel antibiotic therapy. In Gram-negative bacteria, where influx and efflux systems located in the Outer Membrane represent a physical bottleneck for any antibiotic to reach a potential target. The aim is to investigate the molecular and cellular mechanisms at the basis of the influx and efflux processes and to teach scientists with different scientific background to go beyond the classical faculty boarder. Bringing nanotechnology, physics, chemistry, computer modeling, pharmacology, microbiology together will facilitate the transfer of expertise acquired within the network in both academic and industry. To achieve these goals we propose a training program allowing young researcher to collaborate across traditional faculty boarder. Three partners from the private sector will actively participate, the first one is a SME developing unique nanodevices allowing high-throughput drug screening in the field of electrophysiology, the second one is engaged in developing novel antibiotics and the third one is working on drug screening and characterization. Moreover three global pharmaceutical companies will accept students for secondments.",MOLECULAR BASIS OF ANTIBIOTIC TRANSLOCATION,FP7,31 August 2017,01 September 2013,3304341.0 TRANSPINS,Autonomous University of Barcelona * Universitat Autònoma de Barcelona,information and communications technology,"A Monte Carlo spintronic device simulator will be developed. This simulator will be the first of its kind taking into account the concurrent action of the D'yakonov-Perel', Elliot-Yafet, Bir-Aronov-Pikus and hyperfine interaction spin relaxation mechanisms. The underlying band structure model for the simulator will be extended to include spin and the relevant spin splittings, and from there the spin dynamics will follow. The Datta-Das and the Resonant Spin Lifetime transistors will be analysed. Other proposals for spin injectors (ferromagnet/tunnel barrier/semiconductor, RTD with dilute magnetic semiconductor well layer, asymmetric RTDs) will be studied, and improved and/or novel designs will result. Since lots of the suggested devices rely on transport with purely quantum effects (e.g. resonant tunnelling, interface properties) in nanostructures, different methods for the computation of the transmission coefficients will be studied. In particular, the performance of the Multiband Quantum Transmitting Boundary Method will be tested against the Green's function approach. The transmission coefficients (scattering matrices in their general form) completely characterise quantum transport, and they will be used to treat the coupling of the semiclassical and quantum regions in the device simulator.",Transport of Spins in Semiconductors,FP6,31 August 2007,01 September 2005,80000.0 TRANSPORET,University of Leuven * Katholieke Universiteit Leuven,health,"This research programme is dedicated to the development of rationally designed transmembrane molecular machines. Proteins that undergo nanomechanical transitions to facilitate transmembrane communication, or that operate as transmembrane pumps, rotary motors, and molecular transporters are ubiquitous in nature. Despite much progress in the development of solid-state and chemical nanomechanical devices such as molecular rotors, walkers and logic devices, no such systems have been developed that operate across lipid membranes. Thus, by exploiting our knowledge of biological and synthetic supramolecular components we seek to construct some of the first ever transmembrane molecular machines built to man-made specifications. Mirroring the operation of biological transmembrane molecular machines, compartmentalisation facilitates the construction of nanomechanical devices that can be driven by electrochemical gradients, or those that operate in the reverse sense by turning over chemical fuels to establish non-equilibrium conditions. We intend to demonstrate these principles by combining nanopore-based techniques and DNA-recognition processes to assemble a range of membrane-spanning nanomechanical devices that can be operated, controlled and monitored down to single-molecule levels: Project 1 -Transmembrane logic & signalling on the single-molecule level. Project 2 -A transmembrane transporter. Project 3 -A transmembrane reciprocating pump. Project 4 -A transmembrane rotary motor.",Transmembrane Molecular Machines,FP7,31 August 2018,01 September 2013,1499780.0 TRASNADE,Leipzig University * Universität Leipzig,manufacturing,"TRANSNADE is designated for the study of the transport properties of nanoscale assemblies and devices fabricated from polymers and polyelectrolytes, such as polyelectrolyte multilayers, polyelectrolyte brushes, polymer micelles, and polymersomes. Transport properties are fundamental for the rational design of delivery devices since the mechanism of transport will finally define release properties. For most of the mentioned nanodevices, transport properties are adjusted in an empirical way. A deeper understanding of the underlying principles and mechanisms of transport of matter is highly desirable. Polymer nanoassemblies in aqueous environments are heterogeneous and at least partly random systems. A complex scenario of interactions for the diffusing species with the nanomaterial can be expected resulting in unusual transport properties. Measuring transport properties at the nanoscale requires novel experimental and theoretical approaches. A multidisciplinary approach is needed, ranging from synthesis, self assembly, to physical chemistry and theoretical physics. TRANSNADE is formed by an international team with the required and complementary expertise. The expertise of Prof. Gao, from Zhejian University , in synthetic chemistry and self assembly together with the expertise of Dr. Moya, from CIC biomaGUNE, in materials science will be paramount for the creation of polymer with specific functions to be integrated on devices and assemblies. Prof. Donath from the University of Leipzig will develop a novel reaction-diffusion approach for diffusion measurements in nanoassemblies. Electrochemical measurements of transport will be performed by Dr.O.Azzaroni, from INIFTA and Dr.Moya will focus on solvent transport by designing an optical setup combined with QCM. Prof.V.Arakelyan from the Yerevan State University and Prof. Donath will join together their expertise in theoretical and soft matter physics to model experimental data and establish a mechanism for transport.",Transport studies on polymer based nanodevices and assemblies for delivery and sensing,FP7,05 July 2016,12 January 2010,306000.0 TRIBO-SCALE,National Center for Scientific Research * Centre National de la Recherche Scientifique (CNRS),transport,"Wear induced by debris formation and ejection is becoming a critical problem in many industrial applications. Fretting wear associated to small oscillating sliding displacement is considered as a plague in many contacted systems submitted to vibrations loadings (aeronautics, energy, biotechnology, nanotechnologies etc …). Hence, there is a critical interest to formalize wear degradations and wear rates to predict the contact endurances. Unfortunately, the current formalisms (Archard's law etc …) are still empirical and can take into account the contact size effect. Developing a micro-macro description of fretting wear phenomena, the applicant has recently introduced an extended energy wear formulation which permits to take into account the contact size effect. However, there is now a critical interest to optimize this approach for micro-nano contact scales. Hence, the objective of this IOF project is to extend this research through a 14 months mobility at the Department of Materials Science & Engineering (Nanolab / Suresh group) of MIT (USA). By coupling experimental and modeling developments our common objective is to develop an unified wear approach to quantify the wear rate from nano to macro contact size ranges. In addition to this scientific objective, this IOF project will permit the acquisition of competencies on nano tribology and research management that will be transferred after the return phase to the LTDS-DFI group (France) headed by the applicant.",Development of an unified energy wear approach to quantify the wear rate from nano to macro contact size range: Application to the Fretting Wear Problem,FP7,08 July 2012,08 January 2008,133393.99 TRICEPS,Foundation for Research & Technology Hellas (FORTH),manufacturing,"Polarimetry is a crucial tool in both fundamental and applied physics, ranging from the measurement of parity nonconservation (PNC) in atoms, to the determination of biomolecule structure, and the probing of interfaces. These measurements tend to be extremely challenging as the change of the polarization of light is usually extremely small; typical differences in polarization states are of the order of 10^-5 to 10^-8. Current experimental techniques often require acquisition times of the order of seconds or, in the case of PNC, even many days, limiting the possibilities of time-resolved measurements. Here, I propose to develop optical-cavity-based techniques which will enhance measurements of the polarization sensitivity and/or the time-resolution by 3-6 orders of magnitude. Preliminary data from prototypes and feasibility studies are presented. I propose to demonstrate how these breakthroughs will revolutionize polarimetry, by addressing some of the most important multidisciplinary problems in fundamental physics, biophysics, and material science: a) Testing the limits of the Standard Model with atomic PNC measurements. Current PNC experiments, and more importantly theory, for cesium atoms are limited to precision of about 0.5%. The novel and robust experimental technique I am proposing here affords 4 orders-of-magnitude higher sensitivity, thus giving access to lighter atoms, where the theory can be better than 0.1%, for the most stringent test of the Standard Model, while seeking new physics. b) The measurement of protein folding dynamics. Highly sensitive time-resolved spectroscopic ellipsometry, providing novel dynamical information on protein folding: nanosecond resolved, position measurements of functional groups of surface proteins, which map out the time-dependent protein structure. c) Determination of thin film thickness and surface density with nanosecond resolution, for the study of processes such as laser ablation and polymer growth.","Time-resolved Ring-Cavity-Enhanced Polarization Spectroscopy: Breakthroughs in measurements of a) Atomic Parity Violation, b) Protein conformation and biosensing and c) surface and thin film dynamics",FP7,12 July 2016,01 January 2009,909999.0 TRIUMPH,Karlsruhe Institute of Technology * Karlsruher Institut für Technologie (KIT),information and communications technology,"This consortium proposes the development of network architectures and system solutions suitable for future broadband networks. The main objective is to provide Transparent Ring Interconnection Using Multi-wavelength PHotonic switches and processing to significantly increase the network functionality and capacity. The proposed scenario refers to a high capacity network with transparent connectivity between core/regional-metro rings supporting up to 160Gb/s and metro-access rings supporting up to 40Gbit/s. The required functionality in such architecture will be provided through an optical switching node located at the interconnection points between rings. The design and development of this node will be the focus of the project with the aim to provide a cost effective solution that can transparently offer interdomain connectivity. This solution apart from transparent optical switching will support functionalities currently unavailable in the optical layer. Our breakthrough approach will offer transparent optical grooming/aggregation and multi-wavelength optical regeneration. This transparency enables a variety of rates, protocols and formats that are present in the metro and access network environments and are associated with the requirements of new and emerging services and applications that are rapidly becoming available to the end users. This will be performed using novel passive and active optical technologies offering reduced cost able to replace existing complicated and expensive equipment. These technologies will be developed and deployed in the system context by the project consortium that has a unique combination and complementarity of the required technical expertise and know how. The functionality and performance of the optical switching node will be demonstrated through a network lab trial in which it will be used to interconnect two collector and one core-metro rings.",Transparent Ring Interconnection Using Multiwavelngth PHotonic switches,FP6,31 March 2009,28 February 2006,2749123.79 TROJAN-LIPID-SENSOR,Stichting Katholieke Universiteit * Catholic University Foundation,health,"Modulation of leukocyte adhesiveness is critical to leukocyte function during the immune response. In order to extravasate from the blood stream, leukocyte rolling must be followed by integrin-mediated rapid arrest. Intergins play a crucial role on chemokine-induced arrest of leukocytes on blood vessels. Signaling events mediating adhesion are extensively studied. Increasing evidence underlays the essential role of lipid second messenger as important fine regulators of signaling cascade leading to integrin affinity modulation. To date, no technology has ever been developed to monitor intracellular production and localization of specific lipids in the context of leukocyte recruitment. Imaging of small molecules in real time in living cells is usually accomplished with genetically encoded sensors, which are typically fluorescent proteins flanking a ligand-binding domain. However, sensor development is difficult since proteins undergoing conformational changes upon binding a desired target molecule are minimally available. In this scenario, my project aims to produce sensors for fluorescence imaging of small molecules using RNA. These RNA-based sensors comprise a ligand-binding RNA aptamer and Spinach, an aptamer that binds and switches on the fluorescence of a small- molecule fluorophore allowing imaging of the dynamic changes and cell-to-cell variation in the intracellular levels of phosphatidic acid (PA) and phosphatidil-inositol-4,5-biphospate (PIP4,5P2). This tool could be the first of this kind and could be useful to study many aspects of signaling cascade events, not only for leukocyte recruitments. By using lipid Nano-Biosensor I could be able to make FRET and FRAP studies in order to obtain in vivo qualitative and quantitative data allowing topological and dynamic reconstruction of signaling networks. Moreover lipid Nano-Biosensors could be developed as innovative new markers for cell sorting in FACS and in ImageStream Technology.",Trojan-Lipid-Sensor,FP7,15 September 2017,16 September 2014,359081.0 TRUEVIEW,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),photonics,"Due to the promising potential of evanescent optical waves and surface plasmon polaritons to successfully merge current photonic and electronic technology on the nanoscale, they are generally envisioned as the information carriers of the future. This, however, requires the advanced miniaturization of integrated optical circuitry, which demands great effort not only in fabrication and design, but even more so in the development of accurate control and, above all, a deepest scientific understanding of sub-wavelength-confined light. At present, the thorough understanding of the nanoscale behaviour of evanescent fields and the details of the underlying light-matter interactions are missing, but key elements in modern optoelectronics research. TRUEViEW aims to provide the currently missing fundamental knowledge, by implementing innovative electron imaging techniques as the ultimate tools to directly visualize and characterize photonic and plasmonic nanostructures in both space and time with nanometer and femtosecond resolution. The project takes a bottom-up approach throughout, yielding a systematic and consistent route towards unravelling the working principles of nanoscale-confined optical waves and gaining practical expertise on the manipulation of light in optoelectronic nanostructures. At the same time, the project will pioneer and establish the field of ultrafast electron microscopy in the European research community, as well as newly introducing the novel technique of in-situ Photon-Induced Near-field Electron Microscopy. On the whole, TRUEViEW will lay the groundwork for a myriad of future optoelectronic applications, which include - among many others - sub-wavelength optics, light generation and data storage, nanolithography, quantum computing, quantum cryptography, biophysical spectroscopy and nanosensing. As such, the project will have a strong impact not only all across the scientific board, but also in the European commercial and technological industry.",Time-Resolved Ultrafast Electron Visualization of Evanescent Waves,FP7,30 April 2016,01 May 2014,199317.0 TUCAL,Institute of Photonic Sciences * Institut de Ciències Fotòniques (ICFO),information and communications technology,"This proposal concernes the theoretical investigation of ultra-cold atoms in lattices, with special attention to the strongly correlated regime. The scientific objectives consist in the application of innovative methods for strongly correlated systems to describe novel physical situations, obtained through the engineering of the Hamiltonian. We will solve the Bose-Hubbard Hamiltonian using the Gutzwiller ansatz, the dynamical mean-field (DMF) method, the time-evolving block decimation (TEBD) method, as well as exact numerical solutions for small systems. The DMF and the DEBD are respectively a traditional method in condensed matter physics and a completely innovative method for slightly entangled systems, which look very promising for the study of ultra-cold gases. First, we will devote our attention to the study of the excited states and the dynamics of ultra-cold dipolar atoms in a lattice. We will investigate in particular whether the system is characterised by a multitude of almost degenerate states and how in this respect it compares with disordered systems. Our final aim is to draw the bridge with possible applications as neural networks or quantum memories. Second, we will investigate the physics of ultra-cold atoms in non-abelian gauge fields in a lattice, starting from the single particle behavior (presently under investigation), to the weak interacting (mean-field) and strongly interacting (correlated) regime. Our ultimate goal is the investigation of Berry phases, non-abelian Aharonov-Bohm effect and area or perimeters laws for Wilson or t'Hooft loops. The training objectives of the proposal are aimed to bring the applicant to master the named techniques and acquire experience in multidisciplinary fields, ranging from neural networks, quantum field theory and quantum computation implementations, this last area being strongly interconnected with the present proposal from the point of view of theoretical and experimental methods.",Theory of Ultra-Cold Atoms in Lattices,FP6,31 January 2008,01 February 2006,137292.0 TUMOR REPROGRAMMING,Tel Aviv University,health,"Glioblastoma multiforme (GBM) is both the most common and lethal primary malignant brain tumor. In the last century we have accumulated tremendous amounts of data on this type of cancer, but we have achieved very little improvement in its treatment. Despite decades of concerted effort and advances in surgery, radiation and chemotherapy, the median survival is 15 months. The inadequate progress in treatment led us to reexamine the gliomagenesis theory and reconsider the cell of origin of this deadly disease. We recently developed a mouse glioma model using Cre-inducible lentiviral vectors that faithfully recapitulate the pathophysiology of human glioblastomas. Using this model, our results suggested that most differentiated cells in the central nervous system (CNS) upon defined genetic alterations undergo reprogramming to generate a neural stem cell (NSC) or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas. We also reported the transdifferentiation of tumor cells to form tumor derived endothelial cells (TDEC) to generate new tumor blood vessels. I propose a multidisciplinary approach to investigate the mechanisms of tumor cell reprogramming and the potential development of novel therapeutic modalities. I will combine molecular biology, cancer biology, immunology, biochemistry and nanotechnology to address these lines of investigation both in vitro and in vivo in a novel mouse model of GBM.",Targeting Glioblastoma Reprogrammed Stem Cells,FP7,,,100000.0 TUNAMOS,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,information and communications technology,"None of the RF oscillators existing today combines a high quality resonance, a high level of integration (for low power and low cost) and wideband tunability. The recent discovery of the `magnetic flute�, a nanopatterned ferromagnetic device in which high quality tunable microwave oscillations can be generated by a small DC current [S.I. Kiselev et. al., Nature 425, 380 (2003)], opens perspectives to solve the paradigms in microwave engineering design. This project aims at demonstrating the breakthrough concept of the magnetic flute in a nanoscale microwave integrated X-band oscillator for application in the domain of wireless integrated devices. The frequency of the oscillation can be tuned by a magnetic field as well as by the current in a range of 5- 40 GHz. Quality factors as high as 18000 have been observed, making the magnetic flute a natural current-controlled RF oscillator (CCO). This fully electronic device is extremely suitable for integration because of the nanoscale dimensions (diameter of the contact 100 nm) and the simple structure of the metallic magnetic multilayer that is compatible with the back end flow of standard Si or III-V technology. The projects aims to study the oscillating modes as well as the influence of parameters (e.g. temperature, geometry,�) on the microwave frequency, power and phase noise. A potential bottleneck for exploitation of this nanomagnetic oscillator is low output power, however, monolithic integration with a high-gain RF amplifier is expected to boost the output power to levels desirable in wireless applications. The integrated oscillator will be implemented in the standard CMOS 65/90 nm technology node to fully profit from the cost/scalability economics reflected by Moore�s law. This oscillator has the potential of bringing closer the vision of integrating flexible and agile low-cost radio capability into every silicon product of the intelligent environment of tomorrow�s society.",Tuneable nano-magnetic oscillators for integrated transceiver application,FP6,31 August 2008,31 May 2005,1660775.0 TUNEFIELD,University of California,information and communications technology,"The tunability of physical properties by application of an external electric field has created great excitation, mainly related to the development of new field effect transistors (FETs). The use of the field-effect approach to materials other than semiconductors brings many interesting opportunities in basic science and for the design of new electronic devices. This recent line of research is very appealing for electronic structure methods based in first principles, because a quantum mechanical description at the atomic level is required to understand the physical processes involved. The problem of a periodic crystal in a finite macroscopic electric field is a challenge from a fundamental point of view. The difficulties come from the unbounded nature of the quantum-mechanical position operator, and the fact that in a macroscopic field the electronic wavefunctions are no longer of the Bloch form because the potential is 'non-periodic'. Only recently have these fundamental problems been understood, and a few 'ab initio' implementations of the algorithms required for studying electric fields in materials are now available for studying relatively simple systems (few atoms). This is enough for basic research, but not for the application of these methods to realistic nanodevices. Computer simulations of materials are a powerful scientific tool in physics, material science, surface science, chemistry, biology, or earth sciences. Nanotechnology will require simulations of systems with hundreds of atoms under the effect of electric fields. This research project proposes the implementation of tools to perform these calculations. Our main interest is the use of these tools for the study of the new electronic devices whose physical properties can be tuned by electric fields. The dielectric properties of SrTiO3/BaTiO3 superlattices, the electro-optical properties of semiconductor nanostructures and the electromechanical properties of nanotubes will be investigated.",First principles studies of the field-inducedtunability of dielectric properties,FP6,15 September 2008,16 September 2005,251595.0 UCHEM,University of Nottingham,information and communications technology,"The Applicant has an outstanding track record of achievement and an international reputation for independent research in non-aqueous uranium chemistry. This high-impact, challenging CoG Proposal integrates four innovative ideas in uranium chemistry into a single overarching inter-/multi-disciplinary project to open up new horizons across molecular, catalysis, materials, magnetism and energy research. The Applicant’s ERC StG has been very successful and opened new doors to several new avenues of pioneering research that were not even conceivable before the work was done. This work extends out from the knowledge achievements of the StG into new, exciting research areas that are completely different. This is a strategically vital to understand yet poorly developed area due to legacy nuclear waste. This project will deliver innovation through studying: (i) uranium-nitrogen triple bonds as benchmarks for uranium bonding and for generating new small molecule activation and materials applications; (ii) homologation of CO to close the carbon cycle and sustainably remove reliance on dwindling oil; (iii) single molecule magnets that have applications in data storage, quantum computing, spintronics; (iv) uranium-metal bonds which act as exemplars for intermetalloids and bonding. This CoG will afford the freedom and impetus via consolidated funding to undertake fundamental, speculative research to deliver ‘big-hits’, whole new fields of actinide chemistry, and, based on this higher platform of understanding, new ways of thinking. This will induce previously impossible paradigm shifts in uranium chemistry and be included in future textbooks. This project addresses priority subjects in FP7 and the ERC, and, via an extensive network of international academic and industrial collaborations, will consolidate the PI’s team in an exciting, curiosity-driven environment, reverse a strategic skills shortage, and deliver high calibre, cross-disciplinary scientists for the EU.","Frontier Non-Aqueous Uranium Chemistry: Structure, Bonding, Reactivity, and Nanomagnetism",FP7,09 June 2021,10 January 2014,2122596.0 UCNANOMAT4IPACT,Center for Cooperative Research in Biomaterials * Centro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE),health,"Upconversion nanoparticles (UCNPs) have outstanding optical and magnetic properties, which make them extremely suited for application in cancer phototherapy and imaging. They efficiently convert low energy near infrared (NIR) light to higher energies in the visible. The so-generated upconverted luminescence can be exploited to photoactive anticancer metal complexes, a promising class of compounds studied as novel photochemotherapy agents. UCNP-mediated NIR activation will allow overcoming metal complexes' light absorption limitations, simultaneously achieving considerably higher tissue penetration and preserving photochemical reactivity. Indeed, the rich photochemistry of metal complexes can result in unique cell killing modes, critically important in the development of novel anticancer prodrugs. The project aims at investigating the use of UCNPs in the photoactivation of promising anticancer metal complexes, and more specifically at developing new nanomaterials where these two components are integrated to give a superior prodrug. Anchoring photoactive anticancer coordination compounds on UCNPs can produce materials with optimal photophysical and photochemical properties for chemotherapy. Moreover, the chemical versatility of UCNPs offers opportunity for functionalization with biological vectors, which improve biocompatibility, targeting and selectivity features of these integrated nanomaterials in cells and tissues. Remarkably, UCNPs are also excellent new candidates for multimodal (optical/MRI/PET) bioimaging. Their upconverted luminescence, magnetic resonance relaxivity and radioactivity (ease of 18F-labeling) will serve to visualize fundamental biological events with high spatial resolution, which are key to study the photoactive nanomaterials' anticancer action as well as for their medical use. All such features combined together have the potential to deliver innovative therapeutic and imaging agents for cancer phototherapy.",Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy,FP7,14 January 2017,15 January 2013,100000.0 UDENOP,King's College London,photonics,"After a decade of existence, and driven by a remarkable expansion in research and development, plasmonics –the technology that exploit the unique optical properties of metallic nanostructures to enable routing and active manipulation of light at the nanoscale- has entered a defining period in which researchers will seek to answer a critical question: can plasmonics provide a viable technological platform which includes both passive and active nanodevices? The design of these devices is driven by a two-fold objective: 1) to manipulate electromagnetic energy at the nanoscale, including harvesting, guiding and transferring energy, with high lateral confinement down to a few tens of nanometers, and 2) to generate ultrafast and strong non-linear effects with low operating powers to produce basic active functions such as transistor or lasing actions. Utilizing the resonant properties –field enhancement and spectral sensitivity- of Surface Plasmons Polaritons (SPPs) is generally thought to represent a practical avenue to achieving this objective. In this context, this research aims to assess the potential for defects to enhance the non-linear optical properties of plasmonic crystals. The objective is to integrate defects, made of plasmonic cavities, in plasmonic crystals to create a focal point for electromagnetic energy stored in surface plasmon waves at the crystal's interfaces. The role of the defect is then to transfer this energy to a neighbouring non-linear material in order to change its optical properties at the femtosecond timescale, thus creating an active functionality. This research, largely based on ultrafast time-resolved near-field optical microscopy, is also expected to enhance our understanding of ultrafast energy transfers at the nanoscale- a critical expertise in designing nanodevices.","Ultrafast Dynamics, Energy Exchanges, and Non-linear Optical Properties of Resonant Nanostructures",FP7,31 January 2016,01 February 2012,100000.0 UHMSNMRI,University of Turin * Università degli Studi di Torino,health,"The widespread use of magnetic resonance imaging (MRI) technology in clinical and scientific research has attracted great interest in designing high relaxivity contrast agents to improve their sensitivity for the early stage detection of cancer. A number of nanostructure-based T1 contrast agents have been reported in recent years but they are still suffering some limitations for an efficient translation to in vivo applications. In this proposal, we'll develop a novel Gd3+-loaded ultrasmall hollow mesoporous silica nanosphere (Gd-UHMSNs) platform as high sensitivity MRI probes for targeting T1-MRI of small animal tumor xenografts and potentially, of cancer patient. The specific aims for the proposal are (1) synthesize UHMSNs, and design routes to couple the particles with Gd-complexes, PEG, RGD or other targeting vectors; (2) evaluate the relaxivity, toxicity, specific targeting capabilities of Gd-UHMSNs-RGD through tests in cell culture; and (3) evaluate the targeting agents for MRI detection of tumors in different types of mice models. Compared to the current contrast agents, the Gd-UHMSNs-RGD hopefully will show many advantages such as (1) the nanoporous and hollow structural will offer effective geometrical confinement of the Gd-complex and water molecular for enhances the r1 relaxivity, (2) the small particle size < 50 nm, high dispersivity and low toxicity is expected to avoid the RES uptake and efficiently prolong the half-time of circulation in body, (3) the RGD vectors will allow the accumulation of the particles at the tumor endothelium and at the tumor cells. Success of this project can not only provide theoretical insight to the development of nanoparticle-based high relaxivity and targeting contrast agents, but also guide us to develop a novel contrast agent for pre-scanning patients and personalized nanomedicine, resulting in great commercialization potentials.",Design and testing of Gd3+-Loaded Ultrasmall Hollow Mesoporous Silica Nanosphere Platform as High Sensitivity Probes for Targeted Magnetic Resonance Imaging of Tumor In Vivo,FP7,27 January 2015,28 January 2013,193726.0 ULEVIS,Sabanci University * Sabancı Üniversitesi,information and communications technology,"The current integrated circuit scaling hits two major roadblocks or walls. One wall is the atomic level feature sizes of the current devices forcing the capabilities of even nano-scale implementations. The other wall is the total power consumed per unit area exceeding the capabilities thermal dissipation techniques limiting the maximum device densities. The solution to the feature size problem is scaling in the orthogonal direction to the conventional device plane - the 3D integration. The solution to the power problem is the use of ultra low power design approaches. However, the 3D integration increases the thermal dissipation problem and ultra low power design can not provide total performance due to low clock speeds unless extremely large number of devices is combined in small areas. We propose a unique combination of ultra low power design approaches and 3D integration to provide an optimal performance to the user. Low power design eliminates the thermal dissipation problem of the 3D integration whereas 3D integration enables dense device integration in small volumes to solve the space-time trade-off in ultra low power design approaches. The result will be a vertically integrated circuit with power efficiencies several hundred times better than current dedicated processors.",Ultra Low Energy Vertically Integrated Circuits,FP7,09 February 2014,09 March 2011,75000.0 ULPPIC,Ghent University * Universiteit Gent,photonics,"It is now generally recognized that current electrical solutions will not suffice to fulfil all requirements for communication on-chip and between chips, which is expected to continue to grow exponentially during the coming years. Therefore we have to look for alternatives. Optical interconnect is a possibility, which is currently heavily investigated, including in my own on-going research. However, the requirements in terms of power consumption are very stringent and the current solutions being proposed are still off by an order of magnitude. Therefore, the objective of this project is to propose, design, fabricate and characterise photonic devices with fundamental lower power consumption through exploiting a large overlap between optical field, active material and electrical drive signals. For this purpose, we will build a completely new photonics integration platform consisting of self-assembled semiconductor materials as the active core element, embedded within strongly confined photonic cavities defined using the most advanced semiconductor fabrication technologies. Thereby we are combining rapidly maturing bottom-up techniques such as colloidal nanocrystal synthesis and semiconductor nanowire growth with traditional top-down technologies for realizing completely new types of photonic devices with an order of magnitude improvement in device performance. To reach this objective I will build a multidisciplinary team with experts in photonic device design, wet chemical synthesis, solid state physics, epitaxial nanowire growth and microelectronic fabrication technologies.",Ultralow power photonic integrated circuits for short range interconnect networks,FP7,31 December 2015,01 January 2011,1341600.0 ULTI,Aalto University * Aalto-yliopisto,manufacturing,"The Low Temperature Laboratory (LTL) of Helsinki University of Technology (HUT) offers expertise, facilities, and equipment for outside users to undertake measurments at temperatures from 4 K down to the lowest attainable to date. ULTI is expected to contribute to scientific progress and technical development in ultra low temperature physics, to serve as a first-rate educational center for young physicists and, because of its long-standing connections with the low temperature research in Russia, to act as a node for scientific collaboration between Russia and EU countries.
The in-house research includes experimental programs on refrigeration, cryogenics and nanofabricated cryosensors, experiemental and theoretical studies of quantum fluids and solids, nuclear magnetism, and electrical transport in nanostructures. The local low temperature research staff consists of 35 persons of whom 6 are professors, 4 senior scientists, 5 post-doctorals, 5 technicians and 2 secretarial employees; the rest are graduate andundergraduate students. The refrigeration equipment includes three nuclear cooling cryostats capable of reaching sub-mK temperatures and five 20-mK cryostats. As a new addition to our facility, we offer for the users full access to our 55 m2 semi clean room with electron beam lithography line as well as limited access to a 2600 m2 clean room, jointly operated by HUT and VTT, the neighboring State Research Center. The staff of the HUT/VTT clean room has expertise on design and manufacturing of nanofabricated cryosensors both electrical and micromechanical.
Of the total research activity at the ULT installation, at most 18% will be allocated to the ULTI visitors. On average at any given time 1.5 EU-sponsored Users would work in the LTL, and about 40 persons participating in 35 different projects could benefit from the ULTI in four years.",Ultra Low Temperature Installation,FP6,31 March 2008,01 April 2004,942000.0 ULTRA PARTICLE,Universiteit Utrecht * Utrecht University,energy,"Solar energy is an attractive source of alternative energy contributing to fossil fuel independence. Research is still needed to bring down the cost of solar cells for commercial use. For this, novel concept solar cell research make use of low cost materials with novel techniques, often at the nanoscale. The main aim of this grant proposal lays in the development of ultra precise nanoparticles with sizes where quantum confinement becomes dominant. With these so called quantum dots (QD) the band gap of any semiconductor can be tailored by changing the size thereby harvesting different parts of the solar spectrum. The applicant has worked for 8 years outside the Netherlands and will endeavour to establish a new research line in quantum dot photovoltaics. This Career Integration Grant will help him to reach a solid starting point from which to apply to project funding in national and international consortia. A nanoparticle source (gas aggregation in vacuum) will enable the production of ultra precise nanoparticles (silicon, germanium, etc), i.e. high size control, which will considerably enhance the quality of the QD solar cell and the involved processes. A second research theme is the use of plasmonics of metal nanostructures (particles) to enhance optical absorption in solar cells. Both field enhancement and plasmonic coupling will be explored. The applicant has extensive international research experience in the field of nanoparticles. Combined with the host expertise in photovoltaics this forms a formidable effort to advance the science and technology of novel concepts in solar cells. The applicant has a tenure track assistant professor position and will start his own research team within the host group. The existing infrastructure and expertise are readily available to make this project a success resulting in a permanent position for the applicant and significant contribution to frontier solid state physics research towards a highly efficient and cheap solar cell.",Ultra precise nanoparticles to harvest light,FP7,31 August 2015,01 September 2011,100000.0 ULTRA-1D,University of Jyväskylä * Jyväskylän Yliopisto,manufacturing,"The main objective of the Ultra-ID Project is to study the fundamental size limits, when the electron transport in one-dimensional (1D) systems can be considered qualitatively similar to macroscopic regime, and to explore qualitatively new phenomena appearing below the certain scale. Project will focus on fabrication, theoretical and experimental study of electron transport in the state-of-the-art narrow 1D objects: normal metals, superconductors, semiconducting heterojunctions and carbon nanotubes. Principal technological objective of the Project is to elaborate old and develop new methods of microfabrication, pushing the reproducible limit of 1D object fabrication down to ~ 10 nm scale. Three independent, but complimentary methods will be used for fabrication of metallic systems: high- resolution e-beam lithography, electrochemical growth of ultra thin nanowires, and progressive reduction of the effective diameter of pre-fabricated 1D objects by plasma etching. Principal technological objective related to activity with 1D semiconductors is the fabrication of high-quality systems enabling application of external potential. Main technological objective related to electron properties of carbon nanotubes is the fabrication of structures suspended on top of a terraced plane or a cleaved edge of superlattice. Research activity with normal electron transport will be concentrated at three main topics: metal- insulator transition in ultra-thin wires, electron decoherence in 1D limit, peculiarities of electron transport in 1D systems with controlled external periodic potential. Study of superconductors will be focused on the problem of quantum phase slips in ultra-thin 1D systems (wires and rings). Experimental part of the scientific activity will include state-of-the-art low noise transport and magnetic measurements at ultra-low temperatures. Theoretical investigation will use modern methods of quantum solid state physics.",Experimental and theoretical investigation of electron transport in ultra-narrow 1-dimensional nanostructures,FP6,31 August 2007,01 March 2004,2400000.0 ULTRAMAGNETRON,Stichting Katholieke Universiteit * Catholic University Foundation,photonics,"The aim of the proposed research is to develop 'opto-nano-magnetism' as a novel approach for future magnetic recording and information processing technology at the junction of coherent nonlinear optics, nanophotonics and magnetism. In particular, we are aiming to investigate effects of light on magnetic order at the nanoscale, to obtain highly efficient and ultrafast (10-12 seconds and faster) optical control of nanomagnets and thus initiate a development of novel technology for unprecedented fast (THz) magnetic recording and information processing, including spintronics. To this aim we have formed a multi-disciplinary consortium of academic and industrial partners with complementary expertise in coherent nonlinear magneto-optics and ultrafast magnetization dynamics, spatially and time resolved magnetooptics, nanophotonics and X-ray nanoprobing of magnetism, atomistic simulations of subpicosecond magnetization dynamics for strongly nonequilibrium ensembles of spins, technology of magnetic nanostructures and their applications in spintronics. The project is directly relevant to NMP-2007-2.2-2 Section of the NMP Work Programme (Nanostructured materials with tailored magnetic properties).",Ultrafast All-Optical Magnetization Reversal for Magnetic Recording and Laser-Controlled Spintronics,FP7,30 November 2011,01 December 2008,3147150.0 ULTRAQUEST,University of Konstanz * Universität Konstanz,photonics,"The aim of the project consists in starting new experiments in which the absolute optical phase of quasi single-cycle light pulses is harnessed to directly control charge transport in quantum nanosystems. The basic concept of this technique relies on the fact that, with ultrashort pulsed laser sources, it is possible to obtain extremely high peak intensities and thus high peak electric fields. Such pulses can be focused on a nano-scale junction of an electronic circuit. The strong field then allows symmetry breaking of the electronic band structure and triggers charge tunneling from one side of the junction to the other one through the potential barrier of the dielectric medium. Since this effect depends nonlinearly on the bias field, a net current results in the limit of phase-locked excitation pulses thus giving rise to temporal resolution and control on the sub-cycle timescale. In this project we want to exploit the described phenomenon in a regime in which it would be possible to study ultrafast electron transport in nanosystems with strong quantum confinement. To this end, we plan to fabricate nanostructured plasmonic junctions in patterned circuits loaded with single quantum systems such as semiconductor quantum dots. To study the quantum charge transport on such systems we need extremely high sensitivities and a control of the current down to a single electron per pulse. In addition, it is extremely important that the pulse that triggers the quantum tunneling of the charges is far from any resonant optical excitation. For these reasons, we will develop a phase-locked Er:fiber laser source equipped with Tm: and Yb:fiber amplifying stages that will be able to generate single optical cycle optical pulses at wavelenghts around 2 microns. We envision that the study of the ultrafast quantum charge transport on samples positioned in the nano-junction will open new exciting parameter ranges and phenomena related to charge transport in quantum systems.",Ultrafast quantum transport in nanosystems controlled via phase-locked single cycles of light,FP7,28 February 2017,01 March 2013,100000.0 ULTRASMOOTH,University of Leeds,information and communications technology,"ULTRASMOOTH is a Marie Curie Research Training Network that aims to i) achieve breakthroughs
in the quality of metallic thin film morphology through the use of advanced ion-beam irradiation and
other techniques and ii) to provide high quality training in the techniques for growth, processing and
characterisation of ultrasmooth magnetic layers to at least 12 researchers. Many applications of ultra-
thin magnetic films rely on the provision of high quality layers with very low roughness. Some of the
applications which need smooth magnetic layers to function include: sensors which depend on control
of the coupling of constituent magnetic layers, magnetic memories, which function by electron
tunnelling through oxide barriers, hard disc read heads and sensors.
This network brings together eight leading academic laboratories and three industrial partners from
across Europe whose expertise lies in the areas of growth, modification and characterisation of ultra-
thin magnetic films. The postdoctoral and postgraduate researchers hired as part of the network team
will significantly advance their knowledge and skills through research, dissemination and training.
Guided by the industrial partners, experiments designed to improve the growth, crystallinity and surface
quality, characterisation and prototype devices will be performed at university laboratories, research
centres, industrial research laboratories and European large-scale facilities such as ILL and ESRF.
The objectives of this network are to:
-Provide a minimum of 324 months of comprehensive researcher training (l/3rd Early Stage and
2/3rd Experienced Researchers) over 4 years.
-Integrate leading expertise in Europe around challenging technical goals and provide holistic
training based on state-of-the-art research, secondments and exchanges and complementary
training in management skills.
-Improve the growth of ultrasmooth layers by understanding the underlying physics
#",Ultrasmooth magnetic layers for advanced devices,FP6,29 February 2008,01 March 2004,1997264.0 ULTRATUNE,JDSU Ultrafast Lasers AG,photonics,"This proposal aims to research and develop a novel tunable ultrafast pulse laser source for use in biomedical applications. Covering the wavelength range from 400 nm to over 1650 nm, and delivering compressed pulses as short as sub-30 fs, the realisation of such a laser source will advance the state-of-the-art by achieving the combination of two key features, high-power and low-noise, which is not achievable using other current approaches. The research approach is to exploit the latest developments in solid-state lasers combined with recent advances in fiber technologies providing a new high-performance architecture. Saturable semiconductor absorber devices acting as nonlinear mirrors (SESAMs) will mode-lock an efficient solid-state ultrafast oscillator to provide compact, robust, low-noise, multi-Watt level seed pulses. Broadband tunability will be obtained via supercontinuum generation in novel microstructured fibers. This new architecture combines synergistically the skills of the host institute (stable SESAM-based lasers) and the researcher (ultrashort pulse generation, manipulation, and control). Within the project, I plan to explore biomedical applications of this novel laser technology in microscopy imaging, nanosurgery, and dentistry in collaboration with international EU partners. These laser sources are likely to have many additional applications outside of the biomedical market. The work will be performed by a researcher from USA with more than 10 years of experience in ultrafast lasers; the last 4 years were with the Ultrafast group at Coherent Inc., an established world leading commercial supplier of ultrafast lasers, and previously 5 years within the College of Optics - CREOL, in the internationally-recognized group of Prof Peter Delfyett. The researcher will be hosted by Time-Bandwidth Products AG at Zurich, Switzerland, a pioneering SME in robust, reliable, high-power, low-noise SESAM mode-locked ultrafast solid-state lasers.","High-power, low-noise, ultrafast tunable laser sources using supercontinuum generation",FP7,30 June 2012,01 July 2010,238482.0 ULTRAWIRE,University of Cambridge,information and communications technology,"The most common traditional materials used in electrical energy distribution systems are copper and copper alloys. Modern applications show an increasing demand for better heat and electric current carrying capacity at the level beyond copper base materials. Nanocarbon materials, such as carbon nanotubes and graphene have attracted attention due to their high electrical, thermal conductivity and exceptional mechanical properties.",Ultra Conductive Copper-Carbon Nanotube Wire,FP7,09 June 2018,10 January 2013,0.0 UNAM-REGPOT,Bilkent University * Bilkent Üniversitesi,manufacturing,"The newly established Materials Science and Nanotechnology Institute (UNAM) is the first national research institute of Turkey in the area of atomic scale materials and nanotechnology. UNAM is growing as a major research facility equipped with all necessary research infrastructure and advanced research tools to carry out forefront R&D activities. This advanced research facility is available to the researchers of all other institutions. As a centre of excellence, UNAM is expected to provide scientific advising for the state of the art research problems in nanotechnology. Through this project, the Institute can rapidly reach its full potential for research and technological innovation and emerge as an internationally competitive center, integrated firmly into the European Research Area. UNAM is recently established; despite wide recognition within Turkey, so far our exposure to the European scientific community has been limited. We strongly desire to improve this and develop connections to and collaborations with European laboratories, university groups and research institutes through mechanisms to be established in this project. However, UNAM currently suffers from a bottleneck in funding of travel, conference organization. In addition, UNAM needs to increase its PhD staff through postdoctoral and research scientist positions, since full faculty positions through the university are very limited. There is need for a number of trained personnel in high-technology equipment relevant to nanotech in Turkey, such TEM, FIB, lithography equipment. The proposed project will allow UNAM administration to offer internationally competitive salaries for young Turkish scientists receiving doctorates every year in the USA, reversing the brain drain, as well as young European scientists with technical expertise. The proposed project will be critical in overcoming all of these difficulties.",Strengthening of Materials Science and Nanotechnology Institute of Turkey as a National Centre of Excellence through European Integration,FP7,01 July 2013,02 January 2008,949999.5 UNCOS,University of Brighton,information and communications technology,"The principal focus of this project is to synthesise carbon nanomaterials and composites with enhanced mechanical and electrical performance using a novel alternative technology. Carbon nanoparticles and polymer composites are formed from the dissociation of critically opalescent fluids via a UV laser. The aim is to produce such materials in a continuous process where the produced material or composite material is synthesised with its final desirable properties in a single to low number of chemistry steps. The project explores the potential of this novel process for the production of new carbon nanomaterials in close collaboration between an academic partner and an SME with the objectives to produce various carbon nanostructures from critically opalescent fluids, to produce carbon nanomaterials with increased electric conductivity, to produce composite materials with improved mechanical properties, to characterise the properties of the produced carbon nanomaterials, to optimise the process conditions and control the resulting structure of the carbon materials, to develop processes suitable for industrial application, to establish new links between academia and SME, to provide access to academic knowledge and infrastructure to industrial partner and vice versa, and to provide staff in industry and academia with transferable skills. The work programme to achieve these goals includes production of novel carbon nanomaterials from carbon dioxide in batch process (specifically carbon nanotubes, carbon nanofibres, carbon platelets, graphene, carbon layers with controlled dielectric properties, and cross-linked polymer composites), construction of a carbon dioxide reactor system for continuous flow process, production of carbon nanomaterials in continuous flow process, analysis of novel carbon nanomaterials, market analysis, risk assessment, selection and optimization of processes for scale-up, and an intensive knowledge transfer programme.",Unique Nanocarbons from Critically Opalescent Solutions,FP7,07 April 2014,07 May 2010,520116.0 UNINANOCUPS,University of Birmingham,energy,"The aim of this project is to design, develop and study unidirectional supramolecular transport wires
containing photo-/electro-active metallo-units using cyclodextrin guest interactions. This is considered a
particularly powerful approach as it permits nanoscale metallo-assemblies to be formed in aqueous solutions
in a programmed fashion. Our strategy will be used to design linear and/or multidimensional vectorial
arrays in which the pathways of electron or energy transfer will be directed through spatial and energetic
control of molecular components.
Cyclodextrin assemblies will be constructed in a programmed fashion by combining different
cyclodextrin-cavity (a, ß, tyfunctionalized metal complexes with guest-functionalized metal complexes.
We will immobilise these nano-objects on various surfaces and study their properties (with a range of state-
of-the-art techniques), with particular interest in probing photo- and electro-induced processes and
elucidating the electrochemical and electron/energy transfer rates at a wide range of spatial and temporal
levels.
The potential of the non-covalent wire approach for application in molecular electronic technology (for
example to create interconnects and diodes), charge transport, electron and energy storage, will be explored.
The supramolecular assembly (bringing the active components in close proximity) of platinum nanoparticles
and photoactive ruthenium complexes could lead to a new design for photoinduced electron storage and
hydrogen gas evolution.
The network will provide a cohesive but flexible framework for training of researchers. Its multi-
disciplinary nature will bring together wide-ranging skills from across the physical sciences that will be
transferred between the groups. The young researchers will gain a high level, internationally competitive,
multi-disciplinary research training at the Chemistry/Physics/nanoscience interface. Added network value is
gained throug",Uni-directional Nanoscale Supramolecular Wires assembled by Photo- and Electro-Active Metallocyclodextrin Cups,FP6,31 December 2007,01 January 2004,1485244.0
UNION,Dublin City University,energy,"UNION will develop nanoparticle (NP) assembly techniques, and assembly monitoring technologies to prepare novel hierarchically-ordered nanoparticle clusters (NPCs). By improving control over the synthesis and assembly of NPs we will produce materials with tailored and predictable properties. Furthermore, by incorporating hierarchical control into the assembly (through the type, size and spatial distribution of the NPs) it will be possible to assess the influence of the hierarchy on properties and develop new functionalities. UNION will investigate how the emergent properties of the assemblies are determined by the architecture of the assembly, the extent of order, and the properties of the component NPs. This will enable tuning of the primary NP properties and the assembly processes to develop significant breakthroughs in nano-devices and next generation complex nanotechnology products. As the ultimate aim is commercial exploitation of our results, in each stage of the development process we will use application driven, scalable and cost-effective processes, incorporating EHS assessment and roadmap preparation towards future industrial deployment. UNION will achieve its objectives through a three stage approach. - Improved NP preparation providing optimised surface chemistry for subsequent assembly - Novel NPC formation (hierarchical nanoparticle assembly) methods - Roll-out of NPCs for three application areas NPC applications will be developed within three core areas corresponding to the different hierarchical structural levels; in suspensions of individual NPCs (biomedical), in supported 2D NPC arrays (optical), and in 3D arrays or nanocomposites (thermoelectric). Our consortium is comprised of multidisciplinary research groups involving 8 partners with ex-pertise in preparation and application of nano-materials. It includes significant industrial participation with 4 companies with specific knowledge and testing capability for the target application areas.",Ultra-versatile Nanoparticle Integration into Organized Nanoclusters,FP7,31 January 2016,01 February 2013,3798053.0
UNITRIDE,University of South Paris * Université Paris-Sud,photonics,"This project aims at investigating the building blocks of an emerging semiconductor technology for high-performance photonic devices operating in the near infrared (NIR). We will make use of nitride semiconductors [Ga(In)N/Al(Ga,In)N] and engineer the electronic quantum confinement at the nanometer scale to realize unipolar devices relying on intersubband (ISB) transitions. While the existing NIR optoelectronic technology is dominated by InGaAsP/InP or GaInAs/GaAsSb-based interband devices, nitride ISB devices will provide superior performance and novel functionalities like wavelength tunability, speed, high power and temperature handling capabilities, temperature insensitivity and material hardness. It is important to outline the novelty of the research in nitride ISB devices, a technology whose performance capabilities and intrinsic limits remain unknown. Our approach consists in applying novel design concepts and recently-acquired know-how on nitride molecular beam epitaxy to the realization of nitride ISB devices with unprecedented performance. The project includes the development of innovative devices which have not been investigated so far, such as electro-optical ISB phase modulators or nitride-based unipolar lasers. The ultimate deliverables are ultra-high-speed electro-optical modulators, photodetectors and lasers. Establishing a new state-of-the-art for design, growth and processing of nitride heterostructures, and developing an advanced know-how on nitride devices are major challenges. The consortium regroups four world-class academic experts on nitride technologies, ISB devices and NIR optoelectronics. The strategy has been designed based on a careful assessment of the risk associated to all tasks. This project is expected to generate strong impacts in terms of photonic applications and IPR issues.",Unipolar Nitride Photonic Devices,FP7,30 October 2012,01 May 2009,1408076.0
UNIVSEM,TESCAN Orsay Holding AS,health,"The current scientific interest and next generation of nanotechnology-based products is combining converging fields and dealing with a large complexity (e.g. organic electronics, nanomedicine). We can see growing needs to visualize, manipulate, modify and characterize nano-objects in a single tool. The aim of the UnivSEM project is to develop a novel multimodal tool combining - a vision capability by integrating scanning electron (SEM), scanning probe (SPM) and optical microscopy (OM) thus enabling multimodal microscopy, - a chemical analysis capability by time-of-flight secondary ion mass spectroscopy (TOF-SIMS) and energy dispersive X-ray (EDX), - structural characterization by electron backscattered diffraction (EBSD), - a non-destructive optical analysis capability by confocal Raman spectroscopy and cathodoluminescence (CL), - a tomography capability by complementary use of novel 3D orthogonal TOF-SIMS, 3D EBSD and 3D confocal Raman tomography (the last method being non-destructive) thus enabling correlation between alternative 3D methods. The proper resolution will be ensured by SEM column improvements, a new SPM design and OM type of Raman microscopy in SEM. Implementation of nano-scale 3D imaging, manipulation and non-destructive optical analysis in one universal instrument will represent a real breakthrough allowing simple operations or analyses in nanotechnology that are problematic or impossible nowadays. The fully functional prototype of the new tool will demonstrate its unique modularity, resolution, data acquisition and simplification of working environment. Direct application of this multimodal tool is expected in many industrial quality controls and in R&D sectors (e.g. photovoltaics, plasmonics and cell-nanoparticle interaction).",Universal SEM as a multi-nano-analytical tool,FP7,31 March 2015,01 April 2012,3596653.0
UP2DM,Trinity College Dublin,energy,"Layered materials represent a diverse and largely untapped source of 2-dimensional (2D) systems with exotic electronic properties and high specific surface areas that are important for sensing, catalysis and energy storage applications. While graphene is the most well-known layered material, transition metal dichalcogenides (TMDs), transition metal oxides (TMOs) and other 2D compounds are also important. The latter materials are of particular interest as topological insulators and thermoelectric materials. Current production methods for these materials make them uneconomical for most commercial applications. The project will develop and explore commercialisation of a unique method developed by the PI for producing single atomic layer materials. It will also evaluate the potential opportunity to commercialise the materials and or devices made using these materials. The project is linked to an ERC Starting Grant awarded to Prof Jonathan N Coleman in TCD called Semiconducting and Metallic nanosheets: Two dimensional electronic and mechanical materials (SEMANTICS). The proposal will seek to up-scale the process which has been developed within SEMANTICS (and which has already generated one patent application), and engage the commercialisation professionals in CRANN and the Technology Transfer resources in TCD to bring this technology out to the market place.",Up-scaling Production of 2-Dimensional Materials,FP7,31 July 2013,01 April 2012,149760.0
UPCON,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),energy,"This proposal is devoted to the synthesis of ultra-pure semiconductor nanowire heterostructures for energy conversion applications in the photovoltaic domain. Nanowires are filamentary crystals with a very high ratio of length to diameter, the latter being in the nanometer range. Nanowires are of significant interest owing to their large surface-to-volume ratio and low-dimensional properties, as well as attractive building blocks of novel devices, including for novel energy conversion applications. The most widely employed nanowire growth method relies on the use of gold, which is known to be an impurity limiting mobility and carrier lifetime in semiconductors. It is generally realized that nanowires with higher purity could enable significant advances in both fundamental studies and technological applications. This proposal combines two complementary and essential aspects of semiconductor nanowires: (i) synthesis in extremely clean conditions and (ii) their application to new concepts of photovoltaic devices. The first part involves the use of Molecular Beam Epitaxy (MBE) system for the synthesis of III-V semiconductor nanowires and heterostructures. Special emphasis will be given in the synthesis of new heterostructure designs, i.e. across the nanowire radius and along the growth axis. The fabrication of ordered arrays of nanowires on large areas and on silicon substrates will also be investigated. In the second part, nanowire based solar cells will be designed, fabricated and characterized. Particular emphasis will be given toward understanding the role of geometry and interfaces in the energy conversion efficiency of the novel nanowire-based solar cells. Here, the high cleanliness and precise heteroepitaxial growth of MBE nanowires will allow us to perform fundamental studies, generating ground-breaking knowledge on the microscopic processes in energy conversion. This project will foster the use of nanotechnology in the energy challenges of the XXI century.",Ultra-Pure nanowire heterostructures and energy CONversion,FP7,31 December 2014,01 January 2010,1286000.0
UPGRADE,University of Strasbourg * Universitè de Strasbourg,information and communications technology,"UPGRADE targets a fundamental breakthrough by achieving the first proof-of-concept of chemically controlled engineering of graphene nanoribbons (GNRs), through a novel and fast bottom-up patterning technique, which will enable the atomically-controlled fabrication of patterned GNRs over large areas. GNRs combine the advantages of graphene with the semiconducting properties required for the design of efficient field-effect transistors (FETs). The challenge here involves the development of an unconventional and innovative technology allowing for the fabrication of GNRs-based FET devices that feature reproducible and tailored electronic properties. In particular, the bottom-up approach is foreseen to provide graphene nanostructures with fully controlled physical, chemical and ultimately electronic properties at the atomic scale and should result in unprecedented graphene field-effect transistors characteristics.",bottom-UP blueprinting GRAphene baseD Electronics,FP7,01 July 2018,02 January 2013,0.0
UPNEX,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),photonics,"The proposed research aims at the investigation of ultrafast nanoparticle excitations, especially in the sub-10-fs domain. To this end, state-of-the-art controlled optical waveforms will be used with pulse durations comparable to the oscillation cycle of light. These sources have been enabling breakthrough achievements in ultrafast science in recent years and the extension of their use in nanoplasmonics also promises novel results. I plan to investigate ultrafast, coupled propagating and localized plasmonic modes via spatially and spectrally resolved photoelectron emission from the nanostructured metal sample as well as scaling effects with femtosecond sources having different wavelengths (800 nm and 1800 nm). Ultrafast photoemission from closely spaced, coupled nanoparticle pairs will also be investigated. With these setups, both quantum and classical effects can be investigated on the photoemitted electrons. These experiments will be enabled by state-of-the-art femtosecond sources, high-resolution electron spectrometers and nanofabrication methods available at the host institute. These will be ideally complemented with my know-how of the applicant in femtosecond technology and ultrafast photoemission experiments. The extension of this know-how towards nanoscience is an expected benefit as a result of the research stay.",Ultrafast phenomena in nanoparticle excitations,FP7,31 May 2014,01 October 2012,192956.0
UPTEG,Higher Institute for Electronics and Digital Training * Institut Supérieur de l'Électronique et du Numérique,energy,"The performance of thermoelectric generation has long since been limited by the fact that it depends on hardly tunable intrinsic materials properties. At the heart of this problem lies a trade-off between sufficient Seebeck coefficient, good electrical properties and suitably low thermal conductivity. The two last being closely related by the ambivalent role of electrons in the conduction of both electrical and thermal currents. Current research focuses on materials composition and structural properties in order to improve this trade-off also known as the figure of merit (zT). Recently, evidences aroused that nanoscale structuration (nanowires, quantum dots, thin-films) can improve zT by means of electron and/or phonon confinement. The aim of this project is to tackle the intrinsic reasons for this low efficiency and bring TE conversion to efficiencies above 10% by exploring two unconventional and complementary approaches: Phononic Engineering Conversion consists of modulating thermal properties by means of a periodic, precisely designed, arrangement of inclusions on a length scale that compares to phonon means free path. This process is unlocked by state of the art lithography techniques. In its principles, phononic engineering offers an opportunity to tailor the phonon density of states as well as to artificially introduce thermal anisotropy in a semiconductor membrane. Suitable converter architecture is proposed that takes advantage of conductivity reduction and anisotropy to guide and converter heat flow. This approach is fully compatible with standard silicon technologies and is potentially applicable to conformable converters. The Micro Thermionic Conversion relies on low work function materials and micron scale vacuum gaps to collect a thermally activated current across a virtually zero heat conduction device. This approach, though more risky, envisions devices with equivalent zT around 10 which is far above what can be expected from solid state conversion.",Unconventional Principles of ThermoElectric Generation,FP7,30 September 2018,01 October 2013,1499506.0
UROOF,Holon Institute of Technology,information and communications technology,"The key goal for UROOF is to investigate building blocks for enabling the delivery of Ultra-wideband (UWB) radio signal over low-cost optical fiber. The aims are therefore to study, develop, test and implement very low cost conversion solutions for direct optical-to-UWB (O/UWB) and UWB-to-optical (UWB/O) based on innovative microwave photonic concepts. Unlike state of the art radio-over-fiber (RoF) technologies that are used in the backbone of the wireless access systems, UROOF will address the challenges of the low-cost wireless personal area networks (WPAN). UROOF will study several approaches including: developing proof of concepts for O/UWB and UWB/O converters based on innovative optically controlled microwave converter (OCMC). A further study will address enhanced electroabsorption transceiver (EAT) to UWB applications. These converters will be integrated with the UWB radio frequency (RF) front-end and comprise the very low-cost access node for UROOF applications. Several UROOF applications will be investigated in the field trial: (i) range extension of WPAN over 1000m carrying real-world UWB signal with 480 Mb/s data rates and, (ii) very low-cost antenna distribution system (VL-DAS) for multicell WPAN applications. We will provide detailed theoretical and practical analysis related to the design, performance, manufacturing and implementation of UROOF novel modules including: performance analysis of the different modulation schemes in UWB to determine the optimum RoF distribution configuration, evaluation of the impact of electro-optical device non-linearities (pulse chirp / chromatic dispersion) on the UROOF distribution network, device suitability studies for multiple-access architecture VL-DAS, uncooled VCSEL-based design and optical-UWB link analysis. The UROOF partners form a highly balanced and complementary consortium, which has vast experience in the conception, design and manufacturing in both photonic components for RoF and UWB radio domains.",Photonic Components for Ultra wideband Radio over optical Fiber,FP6,31 December 2008,30 June 2006,2200000.0
UROSENSE,Dublin City University,health,"UroSense is a focussed research programme to generate new concepts from knowledge creation to knowledge transfer between innovative academic and dedicated industry partners utilising a systematic intersectoral secondment programme. The programme brings leading edge academic European LifeScience capacities of Diabetes research at Dublin City University, Ireland, together with the high-profile protein research center of University of Luxembourg to establish innovative biomarker utilisation. The nano-biotechnologies developed with established life science applications of Tethis S.p.A of Milano, Italy will be the SME partner to translate findings to microfluidic applications while GE Medical System of Sweden will integrate results to the recently established, robust molecular imaging technologies leading to novel diagnostics for the benefit of the diabetes patient. The Chinese partner is a leading biotech company in Guangzhou who will provide not only validation of results but also to develop access to the fastest growing global healthcare market benefiting both academic and industrial partners. All European partners are unequivocally in the leading edge in their own sectors sharing the vision of true impacts achieved with a new collaborative working model including efficient knowledge transfer and a shared clear scientific focus. Our consortium is particularly well balanced, focussed and well resourced to cover the value chain from discovery research to applications utilising novel intersectoral collaborations to expedite the utilisation process.",Biomarker Applications for Nanotechnology and Imaging in Diabetes,FP7,31 December 2015,01 January 2012,2482306.0
USOM,Swiss Federal Institute of Technology Lausanne * École Polytechnique Fédérale de Lausanne (EPFL),photonics,"The coupling between light and mechanical motion through radiation pressure enables both fundamental experimental research into the quantum behavior of macroscopic objects as well as new technological applications such as light-actuated high-frequency resonators. Crucial to both is the realization of strong optomechanical coupling. We propose to develop novel optomechanical systems that exhibit ultrastrong interactions between light and motion to achieve cooling of a mechanical oscillator to the quantum ground state and to demonstrate new optomechanical functionality. Miniaturized silica toroidal resonators supported by 'spokes' serve as optomechanical resonators with small effective mass and ultra low loss, which are expected to enable ground state cooling. Moreover, we will use two-dimensional photonic crystal cavities in which phononic and photonic modes are highly co-localized to achieve ultrastrong coupling between a cavity mode and high-frequency mechanical oscillations. These systems can perform as all-optically tunable GHz oscillators. The strong coupling and low effective masses of these systems, as well as straightforward integration on a chip, make photonic crystal cavities promising candidates for a next generation of cryogenic quantum experiments. Finally, we will explore for the first time the possibilities of optomechanics in plasmonic systems, which concentrate electromagnetic fields in nanoscopic volumes to achieve giant light-matter interactions. The applicant, Ewold Verhagen, performed his PhD research at the FOM Institute for Atomic and Molecular Physics in Amsterdam, The Netherlands. He published a total of 15 papers in the field of nanophotonics. His main achievements include the demonstration of adiabatic nanofocusing of light and the realization of angle-independent negative index metamaterials at optical frequencies. The host is the Laboratory of Photonics and Quantum Measurement at the EPFL, led by Tobias Kippenberg.",Ultrastrong optomechanical coupling for quantum optomechanics experiments and novel radiation-pressure devices,FP7,31 December 2013,01 January 2012,186028.0
UVTECH,University College Cork,information and communications technology,"Recent developments in the design, synthesis and fabrication of nanotechnology-based materials have the potential to revolutionise several emerging technology markets in sectors ranging from automotives to nanoelectronics. UVTECH addresses the urgent need for Europe to develop radically innovative processing techniques that will enable the sustainable and competitive manufacture of new high knowledge content nanocrystal-based smart materials that will be the drivers for new generations of products. The central project focus will be design, synthesis and processing of precursors and nanocrystal-based materials to enable robust photoprocessing-enabled co-deposition of embedded nanoparticles in a host matrix using a new UV Injection Liquid Source CVD system whereby nanocrystals and host matrix may be co-deposited at low temperatures in a single step. Novel methods for co-deposition of ligand-stabilized size-selected semiconductor or metal nanocrystals with host materials will be developed and applied to formation of functional nanocomposite layers. The originality of UVTECH is: Introduces a photochemical step for the first time allowing co-deposition of nano-particles in host matrices in a single step Makes available for the first time new low-temperature pathways enabling production of new materials systems Expands the range of available layer processing platforms by allowing use of temperature sensitive substrates Enables processing and monolithic integration of nanocrystals/composite materials for the first time, opening the possibility of radically new multilayer multifunctional materials UVTech will be an enabling technology for controlled integration of nanomaterials, opening significant opportunities for numerous long-term applications ranging from availability of bulk quantities of nanostructured materials for applications in catalysis, sensing, adaptive coatings and smart materials to provision of new equipment and processes for advanced products.",UV assisted Technologies for Multifunctional Materials Production,FP6,31 July 2009,01 August 2005,2088135.01
V-SMMART NANO,The Bio Nano Centre Limited,health,"This project will produce a new tool, the Volumetric Scanning Microwave Microscope (VSMM), for non-destructive 3D nanoscale structural characterisation. Full development of this new tool will take place ready for commercial exploitation within the project duration. The consortium, comprising three SMEs, a Large Company, an RTD Performer and two Research Institutions, will develop and commercialise the VSMM. The VSMM will probe the local reflection and transmission microwave spectroscopy of key materials properties, measuring complex permittivity, conductivity, resistivity, and magnetic response, and hence structural and chemical material constitution with 3D nanoscale resolution. Workpackages will address the technical development of the tool and demonstrate its ability to characterise the 3D structure in situ at the nanoscale with application to relevant real life systems including nanoparticle drug uptake in biological cells, domain structure in ferroelectric devices and trap mechanisms in solar cells. Integrated into this process is ease of use through dedicated work-flows and intuitive real time visualisation for results optimisation and processing. Methods for calibration and provision of traceability are incorporated into the project from the start: this will ensure that VSMM measurements will be quantitatively meaningful and optimised for accuracy and will ensure the most efficient route to commercialisation and uptake of the VSMM. The project aims to produce significant impact for European SMEs, they will benefit both from the market for SPM probe tips and ancillary equipment (e.g. calibration kits) for the VSMM and as end-users. Finally, the fact that the VSMM will utilise SPM cantilever-probe technology will ensure that it is readily compatible with a full range of other SPM-based tools -opening up its future role in integrated multi-physical materials characterisation at the nanoscale.",Volumetric Scanning Microwave Microscopy Analytical and Research Tool for Nanotechnology,FP7,28 February 2015,01 March 2012,3099933.0
VAIKUTUS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),health,"The principal objective of the present Project is to establish a long-lasting collaboration, to provide a possibility for transfer of knowledge, to enable exchanges of research personnel, and to create an intercontinental network in the area of hybrid inorgano-bioorganic nanocomposites for biomedical and engineering applications. Realization of the Project will lead to the development of novel nanobiocomposites, which are based on natural components specific for particular regions of Brazil and South Africa. The expertise of the consortium partners is mutually complementary, it encompasses synthesis of the nanocomposite precursors (FI), their modification and improvement of synthetic approaches to hybrid nanocomposites (UA), isolation and characterization of natural active compounds and fibres of plant origin (BR2, BR1, ZA) that are coupled with the development of advanced nanophases and hybrid nanocomposites (FI, IT1, IT2, BR1). Main scientific goal of Project consists in the development of knowledge-based high-added value inorgano-bioorganic nanocomposites, natural and nature identical materials, drug delivery vectors, pharmaceutically active compounds, pharmaceutical and cosmetic formulas through valorisation of regional natural resources and scientific expertise. Innovative nanocomposites and their novel components will be characterized using up-to-date facilities available at all partner organizations for comprehensive physico-chemical, mechanical, spectroscopic, and microscopic studies at the nano-scale; followed by assessment of their anti-cancer, anti-parasite, insecticide and antimicrobial performance in in-vitro (BR2, ZA) and in-vivo tests (ZA). Ethical issues of the research will be duly addressed. Results of the Project will strengthen the scientific potential of ERA, will contribute to the sustainable development in participating countries and promote regional development of the Partner Countries.",Novel inorgano-bioorganic nanocomposites for biomedical and engineering applications,FP7,29 February 2016,01 March 2012,735800.0
VALUE4NANO,D'Appolonia SpA,health,"The VALUE4NANO project aims at developing an Implementation Roadmap of 4 value chains and their target products. The Roadmap will include business modelling and planning for a set of pilot lines and it will involve strategic industry and other stakeholders. The selected value chains are: (1) Nano and micro printing for industrial manufacturing; (2) Nano-enabled, depollutant and self-cleaning surfaces; (3) Manufacturing of powders made of functional alloys, ceramics and intermetallics; (4) Lightweight multifunctional materials and composites for transportation. Project specific objectives are: (a) Formation and activation of 4 value chain expert groups, fostering industry alliances and involving key research and innovation actors coming from clustering of European, national and regional projects on the selected value chains; (b) Development and completion of the 4 value chains (VCs) leading to a gap analysis, identifying the needed technical and not technical actions to implement the VCs; (c) Release of a short-medium term Implementation Plan for the selected value chains, including a feasibility study, business modelling and planning on a possible set of pilot lines; (d) Performing roadmapping, networking and exploitation activities in a wide application-oriented network with nano relevance, linking together industry, research institutions, regional, national and international entities, investors, society, ETPs and initiatives on nano and other KETs. The work-programme has been structured to limit the number of deliverables and milestones to key and visible results as well as pragmatic checking points. The Consortium is composed by D'Appolonia (Coordinator), PRODINTEC and NANOfutures Association, which includes several Third Parties from different organizations around Europe (FIAT Research Centre, Fraunhofer-IPA, CEA, microTEC, MBN, Institute of Occupational Medicine, TNO, TU-Dresden and Spinverse) as well as Bayer and Steptoe and Johnson as voluntary group",Value4Nano: Industrial valorization of strategic value chains for nano-enabled products,FP7,31 August 2015,01 September 2013,837000.0
VDW-CMAT,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Van der Waals (vdW) interactions are ubiquitous in nature, playing a major role in defining the structure, stability, and function for a wide variety of molecules and materials. VdW forces make the existence of molecular liquids and solids possible; they largely control protein-protein and drug-protein binding inside our bodies; they give geckos the ability to 'defy gravity' attaching to walls and ceilings. An accurate first-principles description of vdW interactions is extremely challenging, since the vdW dispersion energy arises from the correlated motion of electrons and, in principle, requires many-electron quantum mechanics. Rapid increase in computer power and advances in modeling of vdW interactions have allowed to achieve 'chemical accuracy' (1 kcal/mol) for binding between small organic molecules. However, the lack of accurate and efficient methods for large and complex systems hinders truly quantitative predictions of properties and functions of technologically relevant materials. We aim to construct and apply a systematic hierarchy of efficient methods for the modeling of vdW interactions with high accuracy and capacity to predict new phenomena in complex materials. Starting from quantum-mechanical first principles (adiabatic-connection fluctuation-dissipation theorem), we unify concepts from quantum chemistry (linear-response coupled-cluster and many-body perturbation theory), density-functional theory (ground-state electron-density response), and statistical mechanics (coupled-fluctuating-dipole model). Our final goal is to enable long time-scale molecular dynamics simulations with predictive power for large and complex systems of thousands of atoms. The project goes well beyond the presently possible applications and once successful will pave the road towards having a suite of first-principles modeling tools for a wide range of materials, such as biomolecules, nanostructures, solids, and organic/inorganic interfaces.",Van der Waals Interactions in Complex Materials,FP7,31 August 2016,01 September 2011,1356999.0
VECTORMULTIPROCESSOR,STMicroelectronics Srl,information and communications technology,"The past 10 years have witnessed an explosion of the amount of visual information that must be transmitted and stored efficiently using limited and expensive resources. Advanced video coding that allows orders of magnitude reduction in the required bit-rates is regarded as an enabling technology to move personal communications to a higher level of interactivity. Common features required in personal communication systems are the need for high-quality, low bit-rate video coding implemented in high-performance, low energy consumption and low design complexity hardware platforms. This work aims to research novel embedded CPU architectures that will enable the acceleration of video coding applications in wireless networks by studying the feasibility of a vector multiprocessor architecture. The combination of several vector units running different threads of the same codec has significant potential in achieving leading area/power/cost metrics in real-time video-encoding. Vector Multiprocessing hardware is expected to enable the transmission of high-quality low-bit rate video content in current and next-generation networks and will contribute to make video content transmission as inconspicuous as voice transmission is today. The following clear objectives apply to this research: 1.Evaluation of the amount of data-level and thread-level parallelism in current and emerging video coding standards and specification of a suitable vector ISA for the proposed workloads. 2. Investigation of the micro-architectural parameters for the optimal multimedia vector pipeline coupled to a controlling CPU. 3. Investigations into the memory subsystem, processor interconnect and the specialization of the vector pipeline to support the algorithm threads in the multiprocessor platform. 4. Implementation of the vector multiprocessor SoC using an state of the art ASIC or equivalent FPGA technology.",Vector Multiprocessor architecture for multimedia energy-efficient applications,FP6,31 July 2006,01 August 2005,151853.98
VERSATILE,National Research Council * Consiglio Nazionale delle Ricerche (CNR),information and communications technology,"The use of three dimensional structures for the realization of non-volatile-memories requires that bit storage and selection elements can be stacked up vertically and should therefore be both manufactured in the Back End Of the Line. Silicon is not well suited as a back end semiconductor material, because the high thermal budget required for both deposition and dopant activation, makes its integration with most of the bit storage elements materials impossible. One of the NVM that appear quite promising are those based on cross-bar architectures. Such an architecture allows an increased miniaturization given a certain lateral feature size since they can be vertically stacked. In addition the cost per bit of such an architecture is significantly lower than the conventional CMOS based ones, since the number of photolithographic masks necessary to produce them is lower. In this project we will integrate junction made of II-VI and organic/polymeric semiconductors into cross-bar type memories to obtain a scalable cross-bar non volatile memory with both bit storage and selection elements vertically stacked on on top of the other. The junction material should require a low thermal budget for its preparation to be compatible with the most promising technologies for the bit storage element, such as chalcogenides. The objectives can be summarized as follows: -Making Schottky and p-n type heterojunctions able to stand high currents and with an high Ion/Ion(1/2) able to operate at low voltage. -Demonstrating the integration of cross-bar architecture, made of a junction based on II-VI and/or polymeric semiconductors and a storage element, up to a 100x100 nodes -Demonstrating the scalability of vertically stacked array junctions for memory application by means of e-beam lithography up to the 32 nm node.",Vertically stacked memory cells based on heterojunctions made of hybrid organic/inorganic materials,FP6,31 July 2009,31 January 2006,1858820.0
VIACARBON,University of Cambridge,information and communications technology,"VIACARBON aims to develop carbon nanotubes for vertical and horizontal interconnects for CMOS nodes of 22 nm and beyond, and for NEMS RF switches. Carbon nanotubes are universally proposed as interconnects because of their huge current carrying capacity of 1E9 A/cm2. However, interconnects also need a low resistance, at least as low as copper. As CNTs are 1-dimensional conductors, they have a minimum quantum resistance of 6 kohms, which can only be reduced by laying many CNTs in parallel. The project aims to grow single wall nanotube mats with density of over 1E13 cm-2, by optimisation of the growth catalyst, and convert this into an industrially compatible technology for both vertical and horizontal interconnects. _x000d_",Carbon Nanotubes for Interconnects and Switches,FP7,12 July 2012,01 January 2008,0.0
VIBRANT,Center for Applied Nanotechnology * Centrum für Angewandte Nanotechnologie (CAN) GmbH,health,"Currently, around 30 million people in the enlarged Europe suffer from diabetes, with a prevalence of 7.5% in member states. In recent years the emergence of type 2 diabetes in children and adolescents is a new and serious health challenge to the youth of Europe, their families and society. By 2025, the number of people with diabetes is expected to rise to around 50 million in Europe, thus increasing prevalence to 10.9%. This devastating disease is ranked among the leading causes of fatal cardiovascular diseases, kidney failure, neuropathy, lower limb amputation and blindness. Estimates of annual direct cost of diabetes care in Europe are currently EUR 50 billion. The indirect costs of diabetes i.e. the cost of lost production are as high as direct costs or even higher. Diabetes results from an absolute or relative decline in pancreatic β-cell function and/or mass. Although of ultimate importance for diabetes management and the development of new therapies, hitherto, no clinically established methodology for non-invasive in vivo imaging and quantification of β-cell mass (BCM) exists. VIBRANT proposes superparamagnetic fluorous phase nanocontainers (FPNC), which are functionalized with β-cell specific ligands for in vivo MRI. This combines β-cell specific targeting with the unrivalled MRI sensitivity of supermagnetic particles and the high resolution power of 19F-containing contrast agents, and hence will outperform existing MRI technology. Furthermore, target specific drug-loaded nanocontainers will offer high potential for β-cell directed therapies. VIBRANT will offer theranostic solutions to the utmost urgent problems in the health care management of diabetes, substantially improving the early diagnosis, thus preventing distressful and costly complications, contributing to the development of new therapies for the regeneration of β-cell mass, and thus directly impacting health status and life quality of patients, health care budgets and economies within the EU.",In Vivo Imaging of Beta cell Receptors by Applied Nano Technology,FP7,30 June 2013,01 July 2009,8073000.0
VIMPA,Sant'Anna School of Advanced Studies * Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna,information and communications technology,"The goal of VIMPA is to develop a new class of high energy and high power density generators to be embedded in portable or autonomous devices. The addressed domain is the one of Power MEMS, i.e. Micro Electro-Mechanical Systems able to exploit combustion for mechanical and electrical power generation. Output densities are projected to reach many W/cc for power, while energy densities up to many KJ/cc are expected: both values are several times higher than the respective upper values of traditional batteries. Few attempts have been and are being conducted worldwide (mainly in the USA and in Japan) in the field, but no usable products have been developed, despite the strong need for miniature high performance power supplies and in spite of dedicated research programs and funding. The main reason of this delay is the adopted approach which consists of scaling down traditional engines, by developing micro turbomachinery or microengines inspired by already existing concepts. VIMPA aims at introducing a discontinuity in the Power MEMS technology by developing vibrating frictionless structures associated with repeated combustions. The first core idea is to focus on positive displacement machines instead of turbomachinery, where dissipation due to drag forces causes large inefficiencies in the micro domain. The second paradigm is to avoid any rotary or sliding joint in the engine mechanism, thus reducing friction, and to use elastic storing of energy instead of inertial, flywheels-like means, which become ineffective when scaling down machine's size. The enabling paradigm for the success of VIMPA is a real multidisciplinary consortium in which state of the art teams in combustion research, microengineering design and MEMS fabrication are included. VIMPA's goal will allow EU research to excel in an interdisciplinary field, the one of Power MEMS, which has connections, but does not directly fall, within FP6 thematic priorities.",Vibrating Microengines for Power Generation and Microsystems Actuation,FP6,31 July 2008,01 February 2005,1100000.0
VIROMA,Center for Cooperative Research in Biomaterials * Centro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE),health,"Viroma project aims to fabricate multiplexed bead-based arrays as sensing devices on the basis of virus capsid and virosome Layer by Layer-assisted assembly on colloidal carriers. The virosome based platform technology will be suitable for the detection of several analytes ranging from comparatively small molecules, of the size of dioxins to larger biomolecules such as small proteins. Such systems are fast and sensitive, and require due to multiplexing and single particle based fluorometric read-outs only a very small amount of sample for analysis and is, suitable for high throughput analysis. The uniqueness of the approach developed in VIROMA is that the virus particles will retain their specific recognition properties provided by the virus capsides and transfer this specificity to the colloidal carrier. Moreover, the possibility of assembling different virus nanoparticles and virosomes on top of the colloids will result in particles with multiple recognition capabilities, going a step ahead nature. Depending on the analytes size two different detection mechanisms will be employed. If the analyte is a larger peptide or protein, a sandwich immunoassay can be employed with the capture antibody integrated into the virosome and transferred to the bead by means of virosome-membrane fusion. The fluorescence will be recorded with a flowcytometry using a colloidal dispersion of the beads or a laser scanning microscope if the beads are immobilized on a chip. As an example, we will assemble beads capable of detecting troponin, a standard marker for myocardial infarction. For small molecule s specific receptor molecules will be designed for a competitive assay. The project involves a synergic collaboration between two academic institutions: CIC biomaGUNE and the University of Leipzig with the company SURFLAY.",Design of a versatile and fast colloidal sensor based on virus modified particles,FP7,31 October 2017,01 November 2013,1145078.0
VIRUS ENTRY,Humboldt University of Berlin * Humboldt-Universität zu Berlin,health,"Virus infections are a major cause of diseases and death among men and animals. The recent outbreak of SARS and the danger that an avian influenza virus may become pandemic, have clearly shown that members of any virus family can potentially turn into a pathogen. To combat virus infection and propagation, systematic and comprehensive studies both on viral components mediating virus-cell interactions, and on the cell biology behind virus entry are necessary. Our network, teaming academic and industrial groups, is aimed at undertaking an interdisciplinary effort to reveal the diversity of pathways and associated molecular mechanisms of cell entry of enveloped viruses. Research by experimental and theoretical approaches will be directed towards the identification of cellular receptors and of viral fusion proteins responsible for interaction with host cells. Among topics are folding, three-dimensional structure and conformational changes of viral fusion proteins as well as virus triggered signalling cascades in cells. Biophysical approaches will unravel the relationship between energetics of conformational changes of viral proteins and membrane bending and fusion. Together with industrial partners the project will identify potential targets for designed drug development, and will develop virus protein coated nanoparticles as new biotechnological and medical tools. The groups have complementary expertise at the highest standard in all required techniques of virology, molecular and cellular biology, biochemistry, proteomics, structural biology, theoretical and experimental biophysics. A challenging research and training environment in an international setting will provide young scientists with a network wide research-oriented training devoted to the specific aspects of virus entry and to structuring of industry projects and commercial exploitation of results, and a local training in soft skills and basic complementary education adapted to the personal needs.",Molecular Mechanisms of Cell Entry of Enveloped Viruses,FP7,30 September 2013,01 October 2009,3844983.0
VISELCAT,University of Warwick,information and communications technology,"This proposal defines new and unique approaches to the study of electrocatalytic processes at the level of an individual nanoparticle (NP). The project marries the considerable achievements of Dr. Stanley Lai in electrocatalysis (PhD, Leiden) with that of the Electrochemistry and Interfaces Group at the University of Warwick, in high resolution electrochemistry and imaging, to create new frontier research in functional imaging of electrocatalysis. The scientific programme involves the development and application of innovative nanoscale electrochemical imaging techniques which will allow individual NPs to be produced directly on surfaces in a well-defined way, and their individual activity investigated, so that the electrocatalytic responses can be related to NP size, structure and environment. Moreover, the nanoscale methods will allow the investigation of individual NPs within an ensemble, to determine - for the first time - the range of electrocatalytic responses that operate, which is a major open question. The focus is on noble metal NPs and model fuel cell reactions, so that the results will be of immediate interest and impact to the field. The NPs will be produced on novel carbon electrode supports (graphene, single-walled carbon nanotubes, graphite and conducting diamond), in view of the considerable excitement in such materials worldwide for electrocatalysis and electroanalysis. The project will derive significant benefit from impressive facilities, equipment and infrastructure at the Host Institution, including major recent investment in state of the art high resolution microscopy and spectroscopy for materials characterisation. With considerable support and world-leading expertise from the Host group and its collaborators, this project will provide Dr. Lai with an outstanding opportunity to develop personally and professionally, by pioneering a new area of research in a new geographic location.",Visualising Electrocatalysis at the Nanoscale,FP7,05 July 2015,06 January 2011,199549.6
VISIT,Technical University of Berlin * Technische Universität Berlin,photonics,"The proposed STREP focuses on strategic, high-value photonic components and subsystems for scalable economic broadband access and local area networks. The central objective is research on, development, test and exploitation of system-enabling optical transmitters having a completely novel design and/or largely improved functionality as compared to the state of the art. Three key design and performance advancements will overcome limitations of present devices to become future-proof drivers of the European photonics industry: A novel nanophotonic approach of vertical integration of an electro-optic reflectance modulator and a laser implemented into: a) Vertically Cavity Surface Emitting Lasers based on Electro-Optically Modulated Bragg Reflector and b) Edge emitters based on Electro-Optically Modulated Tilted Wave Lasers constituting the basis for future access, local (LAN) and storage area (SAN) networks capable to speeds well beyond 40Gb/s. c) For applications at 16-40 Gb/s (Fibre Channel, InfiniBand standards) a new generation of directly-modulated VCSELs will be developed to bridge the intermediate bandwidth demand in the fastest possible time frame. Epitaxial growth of these structures, processing and design of high-frequency modules will be challenging and demand detailed modelling. The wavelength ranges to be covered are 850 nm, 980 nm, and 1.3 µm. While 850 nm (LAN, SAN) and 1300 nm (LAN, Access Networks) ranges are standard for applications, 980 nm devices may play an important role for very short links. Low power driver circuitry, as well as system integration and performance requirements will be also dealt with within this project. Upon completion a full supply chain from production of epitaxial wafers to test beds for measurements and prototype systems will be established. The economic impact of this work will be systematically enhanced by contributing directly to international standardization activities and roadmaps of this area.",VISIT - Vertically Integrated Systems for Information Transfer,FP7,31 October 2011,01 June 2008,2350000.0
VITRIMETTECH,University of Turin * Università degli Studi di Torino,health,"VitriMetTech aims at educating a group of young researchers to implement methods for cutting edge research on new metallic glasses (e.g. Fe, Mg, Al, Ti-based), also in bulk form, and their amorphous/crystalline composites, for functional, bio-mechanical, chemical and structural micro-part applications. Transfer of results to industrial companies will boost innovation in a part of the Metal sector of the European manufacturing industry. This interdisciplinary proposal by ten of the best European academic research teams with six private sector companies will both improve the availability of materials and technologies in fields were metallic glasses are already in the production line (e. g. magnetic devices), and open up new fields of application in chemistry (e. g. in catalysis and spectroscopy) and electrical and electronic engineering (e. g. motor components and MEMS). VitriMetTech comprises five Research Projects which are designed to achieve the following objectives: 1) Soft magnets with low or zero-magnetostriction for use in inductors and toroid-shaped or flat transformers. 2) Highly magnetostrictive alloys to exploit magneto-mechanical coupling for energy harvesting and cantilever devices. 3) Bio-corrodable Mg-based bulk vitrified metals for implants free of toxic elements and with low elastic modulus. 4) Nano-porous metals made from metallic glass precursors for electro- and heterogeneous catalysis, enhanced Raman spectroscopy, flexible electrodes and actuators. 5) Improving the mechanical properties of vitrified metals for the above applications: suppression of shear banding and attain ductility as a function of sample size, composition, and temperature. The training programme overcomes barriers among traditional disciplines providing top level tuition to 16 fellows (10 ESRs and 6 ERs) on topics spanning from laboratory work for the synthesis and property characterization, to processing and device fabrication, and on a full set of complementary skills.",Vitrified Metals Technologies and Applications in Devices and Chemistry,FP7,30 September 2017,01 October 2013,3465780.0
VLPSIRNA,Technische Universiteit Eindhoven * Eindhoven University of Technology,health,"Virus–like protein particles can be applied as carriers for RNA gene therapy. The release of the RNA, however, is still a major problem. The goal of this proposal is to develop new routes towards the controlled opening of the virus capsid combining the cutting-edge science of bioconjugate chemistry and virology. This project intends to find a suitable carrier among non-infectious virus particles for small interfering RNA (siRNA) to be used for gene therapy. siRNA has the ability to specifically degrade RNA of a particular sequence and selectively stop the production of an abnormal undesired protein, which makes it a very promising therapeutic agent. The major obstacle, however, is to find an efficient method for cellular delivery of the RNA material. Virus-like particles, that are self-assembled protein cages, have the potential to be used as addressable carriers for siRNA. The Finn Group at the Scripps Research Institute has recently developed a method to produce virus-like particles that contain siRNA. The goal of the project is to engineer this particle, such that it successfully delivers the RNA into the targeted cell. This project will have the potential to make significant contributions to the fields of biomedicine and targeted drug delivery, strategically important areas identified by the European Technology Platform on Nanomedicine.",Virus-like particles: the next step in gene therapy,FP7,31 March 2013,01 April 2010,237911.0
VORTEX,University of Antwerp * Universiteit Antwerpen,information and communications technology,In this project I will exploit new possibilities opened up by the recent succesful demonstration of our ability to create electron vortex beams in a transmission electron microscope. Electron vortex beams carry a helical phase and angular momentum around their propagation axis. They form the counterpart of optical vortex beams that were invented almost 20 years ago and have lead to many exciting new applications in optics.,Exploring electron vortex beams,FP7,12 July 2018,01 January 2012,0.0
VSNS,Polytechnic University of Catalonia * Universitat Politècnica de Catalunya,health,"The project focuses on developing voltage-sensitive nanotransducers (VSNs) suitable for long-term monitoring of neuronal membrane-potential. The proposed sensing technology seeks to empower the development of treatments against neurodegenerative pathologies, such as Alzheimer?s, currently hampered by the photobleaching and photodynamic damage associated with conventional voltage-sensitive dyes (VSD). VSNs will exploit the novel concept of electrically tunable plasmon resonant nanoparticles/nanorods (NP/NRs), nanosensors that experience plasmon resonance shifts induced by the electric fields subserving neuronal activation. To this end, a family of capping monolayers endowed with conformational sensitivity to neuronal electric fields will be engineered by construction of chain-ball sensing arms including charged groups and flexible tethering alkyl chains. Other types of NP/NR-neuron interaction will also be studied as enhancers of voltage-sensitivity, including NP/NR-enabled monitoring of membrane nano-displacements (e.g. cellular swelling), variations of membrane refractive index and local heat production accompanying electrical activity. Transient changes in intensity, wavelength and phase of scattered light from neuron-bound NP/NRs will be studied using dark-field and phase sensitive microscopy combined with ultrahigh dynamic range active pixel sensors. NP/NRs of various sizes, shapes and compositions will be synthesised with a range of tether lengths and charged units. VSNs will be studied when bound to supported lipid bilayers, cultured neurons in isolation and cortical slices by simultaneous electrical control of bilayer and neuronal membrane potential and optical imaging/spectroscopy. To support the development and exploitation of the VSN technology, the optimal experimental setup will be integrated with the multielectrode neurophysiology system developed and commercialised by one of the partners.","Voltage-Sensitive Plasmon-Resonant Nanoparticles, Novel Nanotransducers of Neuronal Activity",FP6,31 October 2009,01 November 2006,1780504.0
WADIMOS,Interuniversity Microelectronics Center * Interuniversitair Micro-Electronica Centrum (IMEC) VZW,manufacturing,"WADIMOS proposes to develop a generic technology for the realization of complex electro-photonic integrated ICs using standard CMOS processing technologies. These ICs will contain a photonic interconnect layer incorporating microsource arrays and ultracompact WDM (wavelength division multiplexing) functionality based on silicon nanophotonic wire circuits, driven directly from by the CMOS electronic circuitry. The photonic interconnect layer is intended to be incorporated in between the uppermost copper layers of an electronic IC. The availability of such ICs will benefit many applications in telecom, local access, datacom, automotives, avionics and sensing, on- and off-chip interconnect. Two applications will be investigated in particular: a 100TB/s datalink for a maskless-lithography tool based on a massively parallel e-beam tool and an optical network-on-chip based on a wavelength routed network directly integrated with CMOS circuits. The latter is addressing the expected limitations imposed by future purely electrical interconnects in complex MPSoC systems. These two applications are each backed by an industrial partner and their architectural design will be studied in separate workpackages, resulting in a set of specifications for the subcomponents forming the electro-photonic IC. Based on these inputs the different subcomponents will be designed, fabricated and characterized. The most relevant subcomponent is a III-V silicon heterogeneous multi-wavelength microsource array, which will be realized fully in a CMOS-pilot line, based on a process previously developed by project partners and independently by INTEL/USCB researchers. Finally, the different subcomponents will be integrated into two demonstrators each addressing one of both applications under study.",Wavelength Division Multiplexed Photonic Layer on CMOS,FP7,30 June 2011,01 January 2008,2299982.0
WASCLEAN,SAV - Institute of Geotechnics * Ústav geotechniky,environment,"This project aims to develop novel materials and technologies for remediation of contaminated soils and groudwaters from xenobiotics (e.g. man-made) contaminants, via a programme of knowledge exchange and scientific work actions between 8 partner organisations (6 from three EU countries and 2 from an ICPC country). Chemical and biological approaches will be combined to develop novel technologies for removal of toxic metals/metalloids and recalcitrant organic contaminants from contaminated soil and groundwaters. A range of methods, based on iron chemistry and biogeochemistry, bioremediation and electrochemical oxidation will be employed at laboratory and pilot/field scale, to produce integrated clean-up solutions for problem contaminated sites and contaminants. The project brings together a multidisciplinary consortium of specialists from different areas of contaminated land management, environmental (geo)chemistry, nanotechnology, (geo)microbiology and physical, analytical, synthetic, polymer and surface chemistry, working with a common aim of developing new and efficient methods of contaminant removal from soils, and groundwaters.",Water and Soil Clean-up from Mixed Contaminants,FP7,09 June 2019,10 January 2013,2407958.0
WATER,National Research Council * Consiglio Nazionale delle Ricerche (CNR),environment,"The overall objectives are: strengthening the research potential of the applicant in order to formulate a solid and long term research strategy about nanotechnology applications; increase its visibility in the ERA; determining an impact on the local economy and society through technology innovation. The focus is on the application of nanotechnology to water treatment, aiming to boost the research potential in this emerging research domain.",Winning Applications of nanoTEchnology for Resolutive hydropurification,FP7,03 July 2018,10 January 2012,0.0
WATER4CROPS,National Research Council * Consiglio Nazionale delle Ricerche (CNR),environment,"Water4Crops provides a combination of technical improvements in the field of bio-treatment and agricultural water use within a transdisciplinary identification of novel agri-business opportunities. Water4Crops aims at: a) developing innovative biotechnological wastewater treatments for improved water recycling, b) initiating the co-creation of alternative combinations of bio-treatment, recycling of high value elements, and combinations for bioproducts leading to a better commercialization of biotechnology and agricultural products in Europe and India, c)improving water use efficiency at field level through agronomics, plant breeding and locally adapted new irrigation technologies and accurate crop water requirement measurements techniques. Water4Crops will boost bio-based economy by applying a double track approach.",Integrating bio-treated wastewater with enhanced water use efficiency to support the Green Economy in EU and India,FP7,07 July 2018,08 January 2012,0.0
WATERMIM,"Centre for Research & Technology, Hellas * Ethniko Kentro Erevnas Kai Technologikis Anaptyxis (CERTH)",health,"The present 'WATERMIM' proposal is focused on the advancement and optimization of the MIP technology in order to produce functional materials with well-defined morphologies with respect to pore structure and selectivity for water treatment applications. The project aims at the elimination of the random distribution and the uneven accessibility of receptor sites in the volume of the imprinted material that is crucial for its performance. Such novel materials will immediately gain practical relevance, especially, due to their increased selectivity and superior stability under long and harsh technical conditions. The simultaneous optimization of the imprinting efficiency, polymer membrane morphology and separation conditions will enable the development of a truly molecular selective water purification process, based on affinity interactions that would have a large application impact on the water treatment industry. All types of synthetic organic compounds (i.e., triazines, pharmaceutical compounds and endocrine disruptors) are considered target compounds in the WATERMIM project. More specifically, the present project aims at the following S&T objectives: • Selection of template molecules and synthesis of functional monomers. • Optimization of molecularly imprinted polymer (MIP) composition by computational design techniques and combinatorial screening. • Synthesis of well-defined MIP nanoparticles and microgels. • Production of novel composite membranes utilizing preformed MIP nanoparticles. • Production of composite filters both on organic and inorganic supports via novel grafting techniques. • Synthesis of molecularly imprinted membranes (MIMs) for molecular sensor applications. • Separation and catalytic decomposition of the pollutants. • Advanced monitoring of the target compounds. • Benchmark testing of the produced MIMs for water purification.",Water Treatment by Molecularly Imprinted Materials,FP7,30 April 2012,01 May 2009,2491334.0
WATERULTRAFILTRATION,"Imperial College of Science, Technology and Medicine",environment,"The application of membrane technology in the treatment of drinking water has been rapidly increasing in recent years, and particularly the process of ultrafiltration (UF). While some expertise and research activities relating to UF technology currently exist within the European Union, the applicant, Dr Yu, of the Chinese Academy of Sciences, has unique knowledge and research experience of UF pre-treatment methods, which are essential to the optimal performance of the UF process. His proposed fellowship offers an important opportunity for collaboration between two internationally leading research institutions to advance the technology and facilitate the transfer of Dr Yu’s expertise to Imperial College London and the wider European research community. The proposed Marie Curie fellowship will concentrate on developing novel approaches to enhancing UF performance to achieve higher quality treated water cost-effectively and with greater operational efficiency (e.g. through reduced membrane fouling). The fundamental mechanisms involved in these processes will be investigated at nanometer-scale, which will expose the interactions between floc particles, activated carbon and membrane surfaces. In addition, the combination of coagulation-UF treatment with downstream processes, involving a second stage of UF preceded by ozone oxidation and organics adsorption via waste-derived activated carbon, to further enhance water quality, will also be evaluated in this project. In conclusion, the proposed project is expected to provide important and valuable results for the European research community and for water utilities using UF processes in water treatment plants currently, or planning new plants in the future.",Novel approaches for enhancing the treatment of drinking water by ultrafiltration and evaluating the mechanisms at nano-scale,FP7,09 June 2017,10 January 2013,231283.2
WELLBUS,Imperial College London,energy,"The GalnP/GaAs/Ge tandem triple junction cells are the highest efficiency photovoltaic (PV) devices and are likely to be the first of the 'Third Generation' cells to enter the terrestrial PV market in concentrator applications. They employ three different solar cells stacked on top of each other to capture and convert a wider spectral range of solar radiation to electricity. The commercial viability of concentrator systems depends crucially on the use of the highest efficiency cells. The Strain-Balanced Quantum Well Solar Cell (SB-QWSC) is an innovative, nanostructured cell, pioneered by the Quantum Photovoltaic Group (QPG) at Imperial College, which has the potential to enhance the efficiency of the triple junction cell significantly by replacing the GaAs cell. The SB-QWSC increases tandem efficiency by reducing the absorption band-gap of GaAs resulting in better utilisation of the solar spectrum. Recent experimental and theoretical work based on photoluminescence (PL), photoconductivity (PC) and electroluminescence (EL) studies have revealed that the Quasi-Fermi Level Separation (QFLS) in single quantum well (SQW) devices is smaller than expected in both the dark and the light. This implies lower recombination and hence enhanced efficiency. Furthermore, the SB-QWSC dark currents at concentrator current levels show ideality factor n = 1. This suggests that minimum non-radiative recombination levels can be achieved in SB-QWSC. Finally the exciting possibility of efficiency enhancement by photon recycling can also be considered as the unavoidable radiative energy would be re-absorbed in other wells in a light trapping environment. There is therefore a great need to clarify the mechanisms behind the general efficiency enhancement in the SB-QWSC. This will be done by extending the recent studies on QFLS in SQW devices under light illumination to SB-QWSCs, in particular by the study of an already existing sequence of cells with varia#",Study of Efficiency Enhancement Mechanisms in Quantum Well Solar Cells for Better Utilization of the Solar Spectrum (WELLBUS),FP6,08 February 2006,09 February 2004,167665.0
WEMESURF,AC2T Research GmbH,environment,"Almost all manufacturing techniques of surface preparing (polishing, lapping, deposition, etc.) have reached precision in nanometer scale. Although it is possible to measure sub micrometer structures of these surfaces (topography, thickness of coatings) there are hardly any information available for their functionality in tribological systems or wear characteristics due to nanometer or even micrometer surface effects. So there is a strong need for capable measuring devices and also for a higher level theoretical parameter model to predict behaviours of tribosystem and quality criteria of work pieces. Many nanometer scale measuring systems used for model tribometer and engine tests will provide the necessary data for the theoretical model. With this combination of different results in the theoretical model the real behaviour of tribosystems should be more predictable.So the objectives of this proposal are:Obj. 1: improved 3D-analysis-methods for determination of wear and chemical changes on advanced functional surfaces and coatingsObj. 2: improved analysis methods to describe chemical and metallurgical interactions between advanced lubricants and functional surfacesObj. 3: set up a theoretical parameter and criteria model for wear characterisation in sub micro-metre and nano-metre scaleObj. 4: development of an improved micro-nano-simulation-model to describe the surface and advanced lubricant relevant interactions and wear mechanismsObj. 5: economical impact of improved wear mechanisms understanding and ecological impact of wear reduction/preventionWithin this network the researchers will have the chance for linking their experience of one special topic to other institutes in respect to the superior parameter mode.",Characterisation of wear mechanisms and surface functionalities with regard to life time prediction and quality criteria - from micro to the nano range,FP6,31 October 2010,01 November 2006,3464728.0
WINESENSE,University of Valladolid * Universidad de Valladolid,health,"The Wine industry is an important sector for the EU economy and the development of new wine-related products could lead to sustainable growth and development of the sector. WineSense proposes to improve the extraction process to catch most of the active parts of the polyphenols (present in grapes), to define a suitable formulation for pharmaceutical applications, food, and cosmetics additives based on Solvent Free Microwave Extraction,Microwave Assisted Extraction (MAE), and emulsion-Template techniques combining high pressure and antisolvent effects. WineSense combines the efforts of industry and academia in order to optimize the polyphenol extraction and formulation techniques, intensifying the process and reducing the loss in antioxidant capacity. Only thus we can synthesize an actual active compound that is suitable for health, food and wellness applications, in response to the models and innovative approaches of natural products and the challenges of the European Knowledge-Based-Bioeconomy. This project sets the framework for the transfer of knowledge and long-term collaboration between 3 industrial and 1 academic partners in the field of extraction and formulation of most of the active part of polyphenols (soluble and non-soluble). ToK and collaboration will be fostered through mutual exchange of researchers: 11 researchers from academia and industry will be involved in 88 months of secondments; 2 of them will be experienced researchers recruited to complement the consortium capabilities (36 months of recruitment). Additionally, this project aims at creating strong impact in the involved partners by fostering long lasting networks around its driving technologies such us bio & nanotechnology (EU KETs) and also exploring its potencial applications helping mantein Europe at the vanguard of knowledge technologies. Above all, the combination of partners expertise and capacities will support the success of the project.",Research on extraction and formulation intensification processes for natural actives of wine,FP7,30 September 2017,01 October 2013,950421.0
WIPFAB,University of Southampton,health,"Photonic technologies are set to revolutionise our access to chemical and biochemical information, driven by demand for fast, low-cost, automated chemical analysis in applications from food safety, water quality, security, personal and preventative medicine, pharmacogenetics to point-of-care diagnostics. The low cost and robustness of microfabrication approaches which enabled the mobile phone and digital camera are expected to lead to similarly widespread deployment of chemical and bioanalytical microsystems. Optical techniques play a major role in quantitative chemical analysis and are the mainstay of detection in 'lab-on-chip' systems, but the degree of optical functionality integrated in these systems remains extremely limited, and they have yet to benefit fully from the recent massive growth in photonics communications technologies. Photonic technologies for telecommunications operate in the near infra-red (NIR) wavelength region from 800nm -1800nm, driven by the spectral transmission window in silica optical fibre. However, the ideal molecular 'fingerprint' region for biochemical analysis is dominated by the mid infra-red (MIR) spectral region. Biosensor and lab-on-chip research and commercialisation have both been severely hampered by the lack of an integrated photonic platform which can operate over both the NIR and MIR spectral ranges, and which would enable new opportunities for sensitive, selective, label-free biochemical analysis. This programme sets out to advance the frontiers of biophotonics research in MIR materials systems, integrated photonic components for biochemical analysis and nanostructured photonic materials for light control. New approaches to clinical point-of-care diagnostics will be enabled by realising a mass-manufacturable monolithically-integrated photonics/optofluidic technology for chemical and biochemical analysis in the near and mid-infrared, exploiting advanced spectroscopic techniques for accessible biomedical diagnostic",Wideband Integrated Photonics For Accessible Biomedical Diagnostics,FP7,31 March 2017,01 April 2012,3062006.0
WIROX,University of Brescia * Università degli Studi di Brescia,energy,"Wireless sensor nodes (the so called 'Smart Dust') are autonomous devices incorporating sensing, power, computation, and communication into one system. The incorporation of electrical gas sensors in motes is a scientific challenge which has not been solved yet. The objective of the project is to build up an international partnership to tackle these scientific challenge developing self-powered autonomous nano-scale chemical sensors which harvest energy from the environment. The objective will be pursued by packing together scientists from top level institutions and training young researchers to the twofold task of developing self heated nanowire based chemical sensors and Quantum Dots Solar Cells and integrate the latter for powering the first in a mote. Long lasting collaborations will be developed through exchange of people and realization of different research activities. Primary application will be Energy-efficient Buildings (EeB), which are already some of the largest and most prevalent deployments of 'sensor networks' in the world, although they are not typically recognized as such. Wireless gas sensing of air quality could strongly increase the performance of HVAC systems (among NMP 2012 topics).",Oxide Nanostructures for Wireless Chemical Sensing,FP7,31 December 2015,01 January 2012,317100.0
WISE,IBM Research GmbH,information and communications technology,Semiconducting nanowires and in particular their heterostructures could be of paramount importance for energy conversion. These structures hold great potential to provide a means of manipulating phonons by preserving the electronic properties. Our primary goal is to provide novel semiconductor nanostructures possessing enhanced phonon scattering which leads to a selective reduction of thermal conductivity without affecting the electrical characteristics.,Nanowire Structures for Energy Conversion,FP7,04 June 2015,05 January 2011,0.0
WISSMC,Weizmann Institute of Science,manufacturing,"The objective of this project is to provide access funding for scientists from European institutes who wish to perform part of their research at the Braun Center for Sub Micron Research (WISSMC) at the Weizmann Institute of Science. Under this project European scientists the will have the opportunity to visit the Braun Center, which is among the very few laboratories in the world, and particularly in Europe, which are self-sufficient in terms of the integration of 'state of the art' growth-fabrication facilities and measurement-evaluation equipment. The visitors under this program will be exposed to the very high quality research carried out at the WISSMC in the fields of mesoscopic physics and nano-physics. The transnational access will be provided as specified in section 6 of this Annex. The visiting scientists will be able to study complex semiconductor structures and devices. This will include high purity III-V semiconductor structures grown by molecular beam Epitaxy, miniaturization by optical lithography or electron beam writing and other processing and evaluation tools. The visiting scientists will interact strongly with two groups: excellent theoreticians and experimentalists, all working in strong collaboration under one roof and in this rather focused areas of research. The project will provide new opportunities for EU students to broaden their experience and knowledge in state of the art mesoscopic physics. It will allow graduate students to pursue new opportunities such as post doc positions in the field of mesoscopic physics. EU senior scientists will be able to strengthen their scientific ties with leading scientists at the Weizmann Institute. The project will enhance an extended flow of scientists between Europe and the Weizmann Institute and will thus induce fruitful scientific collaborations. It will help establish new research/technology collaborations with scientists across Europe.","Access to the Braun Submicron Center for research on semiconductor materials, devices and structures",FP6,28 February 2009,01 March 2004,1600000.0
WOOD-NET,Latvian State Institute of Wood Chemistry * Latvijas Valsts Koksnes Kīmijas Institūts,construction,"The project’s objective is to improve the research capacities and to reinforce the S&T potential of the Latvian State Institute of Wood Chemistry (LSIWC) in its scientific excellence with the aim of unlocking its capacity and make it accessible for ERA; to strengthen LSIWC as a central part, which ensures the smooth integration of researchers from convergence and outermost regions in a field vital for the social-economic development of Europe and Latvia such as Forestry and Forest Products. The project embraces thematic priorities such as the investigation of the structure and biodegradation of wood as a construction material and a cultural historical object to ensure its durability and competitiveness in the changing climate and biodiversity conditions; interdisciplinary theoretical wood studies on the molecular and nano-level, and development of technologies for chemical compounds, production of composite materials and energy from wood, its components and other types of biomass; rational utilization of woodworking and wood processing residues for the development of innovative multifunctional products for agriculture, forestry and environment protection. The project will promote the exchange of know-how and experience, formation of strategic co-operation partnership between the related leading European research centres. It will activate the dissemination of scientific information and joint results, will expand the involvement of young researchers in the scientific environment. The project envisages the acquisition of unique research equipment and upgrading of the existing one, which will extend the research potentialities, strengthen the Institute as an international research centre and make it attractive for the co-operation partners. 51 institutions as provisional cooperation partners from 24 countries will predicted: 41 from 20 ERA countries (between them 14 from 9 new EU countries); 10 from 4 ICPC (Eastern European and Mediterranean) countries.",The implementation of research potential of the Latvian State Institute of Wood Chemistry in the European Research Area,FP7,05 July 2013,06 January 2008,1049320.0
WOODLIFE,SP Technical Research Institute of Sweden * SP Sveriges Tekniska Forskningsinstitut AB,construction,"The long term objective of the WOODLIFE project is to provide coated and glued wood products with substantially improved durability for a more sustainable society. The project aims to develop new water-based clear coating systems for wood with improved UV-absorbing properties, and to develop new water-based thermoplastic wood adhesives with improved mechanical properties. The new coating and adhesive systems will be designed through molecular manufacturing of inorganic nanoparticles, nanoclays and composite organic-inorganic binders with predictable and controllable properties. Wood is an excellent building material with a high strength/density ratio and it is a renewable resource. For outdoor use it is, however, necessary to enhance the durability of wood materials due to the high sensitivity for UV degradation. Traditionally, organic UV-absorbers are used in clear coatings for wood, however these substances degrade upon outdoor weathering. New UV-absorbing systems for clear coats will be developed in the project based on nanoparticles of CeO2, ZnO and TiO2. With these new systems the service-life of the coated wood will be extended and the cost for maintenance and wood replacement will be decreased. If the mechanical properties of water-based thermoplastic wood adhesives such as PVAc can be improved it would be possible to use the wood products based on these systems for a longer time, leading to a more sustainable society. It would also be possible to use PVAc adhesives instead of the more expensive MUF/PRF adhesives in some load-bearing applications. Engineered nanoparticles will be developed in the project and will be introduced into wood adhesives in order to improve the properties of wood-adhesive joints. The nanoparticles and nanoclays that will be developed in the project will either be added directly to water-based systems or incorporated in hybrid binders in order to improve the dispersion of the nanoparticles and to improve storage stability.",Extended service-life and improved properties of wood products through the use of functional nanoparticles in clear coating and adhesive systems,FP7,05 July 2015,06 January 2010,2381399.0
WS2,GEIE ERCIM,information and communications technology,"The World Wide Web Consortium's main role is to standardize Web technologies by creating and managing Working Groups that produce specifications (called 'Recommendations') that describe the building blocks of the Web, and produce them freely available to all, as part of the Web open platform.The goal of WS2 is to support the W3C in administering its Web services related standard activities, their wide adoption in the European industry, and their evolution toward achieving efficient and interoperable communications within distributed software, as well as rich and complex interactions, exploring use of Semantic Web technologies.WS2 includes European outreach activities on existing W3C Recommendations and fostering the development of new specifications with significant European participation.The project is led by the W3C European branch, hosted by ERCIM, the European Research Consortium for Informatics and Mathematics.The impact foreseen for this project is that it will enable a wider range of use, from business processes to collaboration tools, of the current generation of machine-to-machine Web Services interaction, as well as promoting the extension of these technologies based on new requirements from the industry, using recent and open technology like W3C Semantic Web technologies.The WS2 outreach activities will increase awareness and visibility of W3C's Web services specifications within Europe and strive to make this W3C work on Web services among the most visible areas of W3C's work in Europe.The WS2 technical activities, done through its European staff, will provide European research and industry with competent partners within the W3C community, providing guidance with the standardisation processes currently in place at W3C through its working groups, studying the state of the art and monitoring the other standardisation activities in the domain (e.g. OASIS), and helping to raise the level of European participation.",Web Services and Semantics,FP6,31 December 2006,30 June 2004,694785.0
X-GEAR,D'Appolonia SpA,manufacturing,"The 135.000 European SMEs of the mechanical transmission sector producers of gears and gearing products rely on traditional technologies and are characterised by a general conservatism. However over the years the end products in which the gears are used have become more complex and are pushing the state of the art in new technology. Thus the requirement for more sophisticated and reliable gears become extremely important. The gear industry has to implement major changes in gear design and gear fabrication techniques just to keep up with the changing needs of the end product. Moreover, the output of mechanical engineering equipment is growing much faster in China than in the Europe or USA. China is thus becoming a serious competitor for the European SMEs of the sector. In line with the strategic objectives of the associations of manufacturers of gears and mechanical transmission systems, the objective of X-Gear is the diffusion and the standardisation of novel technologies and new materials for a new generation of gears characterised by higher accuracy, resistance, reliability, and tribology properties. In this context X-GEAR plays a role in the competitiveness of European industry since aims to comply with the tighter and tighter requirements being put on the gear industry for lighter weight, higher torque transmissions and quieter, more efficient gear trains. Research activities will be focused on an innovative combination of: - New surface treatments based on Flame Spraying, PVD and Laser Shot Peening; - New materials based on nanopowders (namely ultradispersed fine diamonds) for the production of ultra-resistant gears; - Manufacturing and design tools and knowledge platform implementing guidelines and best practices developed in the project, for a wider diffusion of the project results to the IAGs and their members",Development of Gear Drive-Trains Based on New Materials and Novel Gear Systems,FP6,31 August 2009,01 September 2006,1872586.0
XENO-AUTOANTIBODIES,Tel Aviv University,health,"'xeno-autoantibodies' recognize a dietary immunogenic non-self sugar that is metabolized by cells as self and presented on the cell surface. N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form, N-glycolylneuraminic acid (Neu5Gc) are the two major Sia forms in most mammals. Humans are deficient in the enzyme CMP-Neu5Ac hydroxylase (CMAH) that can synthesize Neu5Gc, however dietary Neu5Gc accumulates in epithelial tumors and become immunogenic. Our previous research recognized dual and opposing roles of IgG isotype xeno-autoantibodies in cancer progression, diagnosis and immunotherapy: they facilitate tumor progression via chronic inflammation at low doses, but mediate tumor inhibition at higher doses in a 'human-like' Cmah-/- Neu5Gc-deficient mouse model. Furthermore, we developed a novel sialoglycan microarray that lead to the discovery of a specific xeno-auto-IgG that is novel human serum carcinoma biomarker and potential immunotherapeutic. However, our early studies also revealed that some human sera show high levels of anti-Neu5Gc IgAs that could even be affinity-purified from human serum (7). IgA is the most abundantly produced antibody isotype in the body and the main isotype in mucosal surfaces; It is also present in serum, where IgG is the predominant isotype. I propose a multidisciplinary approach to investigate the biology of IgA xeno-autoantibodies against these unique glycans and their potential involvement in cancer. I will combine glycobiology, immunology, biochemistry, molecular biology, nanotechnology and advanced array techniques to address these lines of investigation both in vitro and in vivo in a relevant mouse model (Cmah-/-).",Immune Recognition of Xeno-Glycans,FP7,28 February 2015,01 March 2013,227231.0
XFEL SAMPLE INJECTOR,Max Planck Society * Max-Planck-Gesellschaft zur Förderung der Wissenschaften eV (MPG),health,"Building upon the Gas Dynamic Virtual (GDVN) technology developed by the researcher at his home institution and upon the very successful use of these injectors for biomolecular structure measurement with seminal X-ray Free Electron Lasers (XFEL's), this project will enhance and expand GDVN capabilities for both the current and the next generation of XFEL's. Specific goals of this project are (1) reduction of sample consumption from the 1-10 microliters/minute of the current GDVN injectors down to under 100 nanoliters/min, (2) development and testing of specific experimental methods (capillary coatings, new GDVN methodology, improved flow systems) to expand the variety of biological samples that can be delivered using GVDN injectors, and (3) porting of this technology and knowledge to the European XFEL communities.",Hydrated Injection of Biomolecules into X-ray Free Electron Lasers (XFEL),FP7,31 October 2013,01 August 2012,140289.0
XLIM,University of Bristol,energy,"This proposal for a Marie Curie Fellowship focuses on the preparation of well-defined nanofibers from conjugated polymers and their use in photovoltaic devices. This project will be highly interdisciplinary and multidisciplinary, involving polymer synthesis, polymer self-assembly in the solution state, polymer crystallography, polymer physics, the physics of semiconducting materials, the fabrication and characterization of photovoltaic devices, and nanoscience. Therefore, this research is expected to have a substantial multidisciplinary impact ranging from polymer chemistry to polymer physics, to materials science, and to expand our knowledge of photovoltaic devices. To achieve the project goals it will be vital to combine the expertise of the applicant, Xiaoyu Li, on nanofibers and polymer-based device fabrication, with that of the host, Prof. Ian Manners, on polymer synthesis and crystallization-driven self-assembly of block copolymers in solution. Mr. Li is completing his Ph.D. in Canada and after working with Prof. Manners in the UK he aims to find a faculty position in China, his country of origin.",Well-defined Conjugated Block Copolymer Nanofibers and their Applications in Photovoltaic Devices,FP7,07 April 2015,08 April 2013,231283.0
XMEMS,Royal Institute of Technology * Kungliga Tekniska Högskolan,photonics,"This proposal targets the development of flexible heterogeneous integration schemes for combining best-of-class materials, components and manufacturing methods into economically viable micro- and nanosystem (MEMS) solutions. Today, the IC industry drives the development of most micro- and nanofabrication technologies, which are characterized by standardized processes, very large production volumes of >10.000 wafers/month and enormous capital investments. In contrast, the vast majority of MEMS demand production volumes of <100 wafers/month and different manufacturing and integration processes for each type of device. The a-priori acceptance of IC manufacturing technologies for MEMS therefore leads to missed market opportunities for many moderate volume MEMS-based products and to sub-optimal material choices. Instead, we aim for a new MEMS-specific integration and manufacturing paradigm, in which the technologies and tools are adapted to the production volumes and design variations of MEMS devices. Specifically, we will develop novel and enabling micro/nano fabrication and integration techniques with a focus on flexibility and cost-efficiency in the following areas: ' Heterogeneous Material Integration, where we incorporate high-performance materials into MEMS using unconventional and innovative technologies and tools, including serial integration, wafer-level integration and free-form fabrication of MEMS; ' Heterogeneous System Integration, where we develop new wafer level schemes to combine, process and interconnect components fabricated with different technologies such as MEMS, NEMS, ICs or photonics; ' Lab-on-Chip Integration, in which transducers, mass transport solutions, surface biochemistry and liquids are combined at the wafer level into high-performance systems.",Towards Cost-Efficient Flexible Heterogeneous Integration for Micro- and Nanosystem Fabrication,FP7,29 February 2016,01 March 2011,2279800.0
YXY FS,Avantium Technologies BV,energy,"The urgency to identify and develop sustainable and timely solutions for our future society has become clearly demonstrated due to the alarming trends in global energy demand, the finite nature of fossil fuel reserves, the need to dramatically curb emissions of greenhouse gases to mitigate the devastating consequences of climate change, the damaging volatility of oil prices (in particular for the transport sector) and the geopolitical instability in supplier regions. In this regard, I started to work since my postgraduated studies in to find alternative and greener methodologies in terms of materials preparation, production of biofuels (which can partially meet the future expected needs of our society in terms of energy for transport), (photo)catalysis as a greener alternative for the production of chemicals and energy as well as biomass and waste valorisation. Biomass from plant is the most important feedstock for food, feed and non-food applications. In the processing of plant materials e.g. wood for paper, substantial amounts of potentially valuable by-products are produced. In this regard, the host organisation, Avantium Chemicals BV, explores unique bio-refinery concepts on novel routes for C6 carbohydrates conversion using nanomaterials. The main objectives are: 1)To develop a range of new multifunctional catalysts (e.g. based on mesoporous silica materials with controlled acidity and metal nanoparticles loading), through synthesis, using a combination of novel techniques 2)To screen their reactivity using model reactions 3)To develop an approach for testing selected catalysts using real feeds from e. g. the pilot plant 4)To optimise the reaction conditions (with emphasis on the reduction of energy consumption aand waste production), evaluation of the catalyst stability. 5)To integrate my knowledge and experience in heterogeneous catalysis into the Avantium R&D environment. In order to achieve these ambitious goals, I will use an interdisciplinary approach.",Producing YXY FUELS from C6 carbohydrates using nanomaterials,FP7,14 January 2016,15 January 2014,183469.0
ZEOCELL,University of Zaragoza * Universidad de Zaragoza,energy,"The PEMFC represents one of the most promising technologies in the field of fuel cells. One of the keys to the success of the PEMFC technology is the development of improved electrolyte membrane materials which can be produced in mass and can operate within a temperature range of 130-200ºC. The ZEOCELL project will develop a nanostructured electrolyte membrane based on a new composite multifunctional material consisting of the combination of 3 materials: zeolites, ionic liquids and polymers -integrating their beneficial characteristics. The membrane will have an innovative structure comprising a 2D polymer matrix and two zeolite layers, with the following properties: - High ionic conductivity: ≥100 mS/cm at 150ºC.; - Suitability for operating at temperatures between 130-200ºC; - Good chemical, mechanical and thermal stability up to 200ºC; - Durability (<1% performance degradation during the first 1000 hours working); - Low fuel cross-over (