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Nanopinion: A protocol for analysing metallic nanomaterials in biological samples
Dr Fazel Abdolahpur Monikh writes about a protocol that helps understand the bioaccumulation and biodistribution of metal-bearing engineered nanomaterials in organisms. The protocol is used to quantify the cellular uptake of metal-bearing engineered nanomaterials on a cell-by-cell basis.
“Tracking and analysing engineered nanomaterials in cells and tissues is difficult. This difficulty arises because there is a limitation in analytics for characterisation and quantification of engineered nanomaterials in bio- and physiological matrices due to their presence at trace levels, and because of the presence of different background materials which interfere with the measurement. Thus, researchers must apply an approach that is not only capable of measuring engineered nanomaterials at trace levels but also of measuring the form of the particles at a specific moment in time.”
Background
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