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Nanopinion: An ancestral molecular response to nanomaterial particulates

Read the latest Nanopinion by Prof. Dario Greco and M.Sc. Giusy del Giudice where they discuss the importance of new generation tests for assessing the potential toxicity across multiple species along with long-term consequences of nanoparticles’ exposure and introduce the One Health principle. 

“The epigenome, namely all the modification of DNA and DNA associated proteins affecting gene expression without altering the DNA sequence, is extremely conserved in the evolution. Therefore, assessing the impact of substances on the epigenetic layer potentially allows to directly translate hazard considerations and toxicological results across species, contributing to the reduction of animal experimentation and streamlining the process to multiple nanomaterials with disparate physicochemical characteristics.”

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