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Nanopinion: Recent progress towards microbiota-inclusive nanosafety research

How can host-associated microbiota affect the toxicity of nanoparticles? In this guest column, Dr Bregje Brinkmann discusses the direct interactions between microbiota, the host, and nanoparticles. Additionally, she elaborates on the latest research conducted on this subject. 

“All multicellular organisms host microbes on their tissues, and these microbes jointly make up the host-associated microbiota. Microbes are important to the health of organisms and play a crucial role at the exposure interface with nanoparticles. [..] Recent advances in the nanosafety field have shown that host-associated microbiota can significantly affect the toxicity of nanoparticles. Mechanistically, this has mainly been explained by the intricate interactions between the host and microbes that colonize the exposure interface.”

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